Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR6B1 VIPR1 OR4D10 OR52D1 GPR173 OR52L1 MC2R GLRA3 SCTR OR5K2 ROS1 GPR183 OR2L13 OR14A16 OR1L1 PRLR TMEM63A

7.46e-0513538817GO:0004888
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR6B1 VIPR1 OR4D10 OR52D1 GPR173 OR52L1 MC2R SCTR OR5K2 GPR183 OR2L13 OR14A16 OR1L1

1.27e-048848813GO:0004930
GeneOntologyMolecularFunctionGTPase activator activity

RALGAPA1 RAB3GAP2 LRRK2 EIF5 RIC8A RALGAPA2 TBCD

2.33e-04279887GO:0005096
GeneOntologyMolecularFunctionL-leucine binding

UBR2 SESN1

3.97e-047882GO:0070728
GeneOntologyMolecularFunctionolfactory receptor activity

OR6B1 OR4D10 OR52D1 OR52L1 OR5K2 OR2L13 OR14A16 OR1L1

6.29e-04431888GO:0004984
DomainGPCR_2_VIP_rcpt_1

VIPR1 SCTR

6.27e-053862IPR001771
DomainARM-type_fold

RALGAPA1 LRRK2 EIF5 RIC8A TAF2 RALGAPA2 AP3D1 TBCD

1.68e-04339868IPR016024
DomainGPCR_Rhodpsn_7TM

OR6B1 OR4D10 OR52D1 GPR173 OR52L1 MC2R OR5K2 GPR183 OR2L13 OR14A16 OR1L1

2.47e-046708611IPR017452
Domain7tm_1

OR6B1 OR4D10 OR52D1 GPR173 OR52L1 MC2R OR5K2 GPR183 OR2L13 OR14A16 OR1L1

2.70e-046778611PF00001
DomainG_PROTEIN_RECEP_F1_1

OR6B1 OR4D10 OR52D1 GPR173 OR52L1 MC2R OR5K2 GPR183 OR2L13 OR14A16 OR1L1

2.99e-046858611PS00237
DomainG_PROTEIN_RECEP_F1_2

OR6B1 OR4D10 OR52D1 GPR173 OR52L1 MC2R OR5K2 GPR183 OR2L13 OR14A16 OR1L1

3.22e-046918611PS50262
DomainGPCR_Rhodpsn

OR6B1 OR4D10 OR52D1 GPR173 OR52L1 MC2R OR5K2 GPR183 OR2L13 OR14A16 OR1L1

3.26e-046928611IPR000276
DomainOlfact_rcpt

OR6B1 OR4D10 OR52D1 OR52L1 OR5K2 OR2L13 OR14A16 OR1L1

4.54e-04393868IPR000725
Pubmed

Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.

IKZF3 IKZF2 IKZF1

1.57e-08388311937265
Pubmed

Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.

IKZF3 IKZF2 IKZF1

1.57e-0838839560339
Pubmed

Analysis of Ikaros family splicing variants in human hematopoietic lineages.

IKZF3 IKZF2 IKZF1

1.57e-08388320432734
Pubmed

Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.

IKZF3 IKZF2 IKZF1

1.57e-08388327502439
Pubmed

Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma.

IKZF3 IKZF2 IKZF1

1.57e-08388318332232
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCSK5 RHPN1 FLNA ZBED4 PCNX4 NISCH MAP3K11 RIC8A WDR90 RALGAPA2 DOCK6 FEM1A AP3D1 MED12 TBCD ANKRD16

1.64e-081105881635748872
Pubmed

Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.

IKZF3 IKZF2 IKZF1

1.56e-07588310978333
Pubmed

A molecular dissection of the repression circuitry of Ikaros.

IKZF3 IKZF2 IKZF1

5.58e-061488312015313
Pubmed

Helios deficiency has minimal impact on T cell development and function.

IKZF2 IKZF1

6.33e-06288219620299
Pubmed

IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma.

IKZF3 IKZF1

6.33e-06288231558666
Pubmed

A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS.

IKZF3 IKZF1

6.33e-06288234155405
Pubmed

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia.

IKZF3 IKZF1

6.33e-06288224509510
Pubmed

Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them.

IKZF3 IKZF1

6.33e-06288233499314
Pubmed

S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding.

FLNA RPS6KB1

6.33e-06288225512366
Pubmed

Genetic mapping and allelic loss analysis in mouse thymic lymphomas of Helios and Aiolos belonging to the Ikaros gene family.

IKZF3 IKZF2

6.33e-06288211173542
Pubmed

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.

IKZF3 IKZF1

6.33e-0628829155026
Pubmed

Suppression of Aiolos and Ikaros expression by lenalidomide reduces human ILC3-ILC1/NK cell transdifferentiation.

IKZF3 IKZF1

6.33e-06288231151137
Pubmed

Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function.

IKZF3 IKZF1

6.33e-06288237662955
Pubmed

Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus.

IKZF3 IKZF1

6.33e-06288233182226
Pubmed

Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros.

VIPR1 IKZF1

6.33e-06288211812772
Pubmed

Critical function of Ikaros in controlling Aiolos gene expression.

IKZF3 IKZF1

6.33e-06288217383641
Pubmed

High IKZF1/3 protein expression is a favorable prognostic factor for survival of relapsed/refractory multiple myeloma patients treated with lenalidomide.

IKZF3 IKZF1

6.33e-06288227881177
Pubmed

Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes.

IKZF2 IKZF1

6.33e-06288217681952
Pubmed

[Expression characteristics of isoforms of Ikaros and Helios in patients with leukemia and their mechanism].

IKZF2 IKZF1

6.33e-06288222931634
Pubmed

Ikaros promotes early-born neuronal fates in the cerebral cortex.

IKZF3 IKZF2 IKZF1

1.47e-051988323382203
Pubmed

The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse.

IKZF2 IKZF1 SEMA3E

1.73e-052088324082127
Pubmed

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

FLNA PTPN13 GUCY1B2 PCNX4 RAB3GAP2 BAZ1B TBCD

1.83e-0532288726514267
Pubmed

Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases.

RALGAPA1 RALGAPA2

1.90e-05388219520869
Pubmed

The genomic landscape of hypodiploid acute lymphoblastic leukemia.

IKZF3 IKZF2

1.90e-05388223334668
Pubmed

Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen.

CD80 ITGAX

1.90e-0538821385153
Pubmed

CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.

LRRK2 CADPS2

1.90e-05388228647363
Pubmed

Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor.

VIPR1 SCTR

1.90e-0538828390245
Pubmed

The CD8alpha gene locus is regulated by the Ikaros family of proteins.

IKZF3 IKZF1

1.90e-05388212504015
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

ABCC1 FLNA ATP6V0A1 NISCH RAB3GAP2 DNAH2 CSTF3 RIC8A POMK STT3A TBCD

2.60e-05942881131073040
Pubmed

Differential expression of the immunosuppressive enzyme IL4I1 in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells.

IKZF3 IKZF2

3.79e-05488225446972
Pubmed

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).

IKZF3 IKZF1

3.79e-05488224328678
Pubmed

DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.

FLNA DPP9

3.79e-05488227614019
Pubmed

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins.

IKZF3 IKZF1

3.79e-05488224292623
Pubmed

Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes.

SH3TC2 GARS1

3.79e-05488228355569
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

ATP6V0A1 CD80 RAB3GAP2 LRRK2 NEK7 ZNF224 ZNF225 RALGAPA2 SEMA3E

6.12e-0568688929987050
Pubmed

Altered expressions of peripheral CD11c, CD80, CD83 markers and associations of HLA class II allele and haplotypes in self-limiting Hepatitis E infection.

CD80 ITGAX

6.30e-05588223246582
Pubmed

Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.

IKZF3 IKZF1

6.30e-05588210766745
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

RALGAPA1 UBR2 VIPR1 PTPN13 DPP9 PCNX4 RPS6KB1 CSTF3 DOCK6 SESN1 STT3A TBCD TMEM63A

9.30e-051489881328611215
Pubmed

Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.

RPS6KB1 EEF2K

9.43e-05688214709557
Pubmed

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin.

RPS6KB1 EEF2K

9.43e-05688215024086
Pubmed

Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression.

IKZF3 IKZF1

9.43e-05688220566697
Pubmed

Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).

SRD5A1 MC2R PRLR

1.24e-043888319574343
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

ABCC1 FLNA PCNX4 DNAH2 NEK7 BAZ1B ROS1 PPFIA3 STT3A

1.25e-0475488935906200
Pubmed

Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells.

IKZF3 IKZF1

1.32e-04788226823144
Pubmed

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.

IKZF3 IKZF1

1.32e-04788210357820
Pubmed

Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction.

PCSK5 PLA1A KCNJ13 SEMA3E

1.51e-0410588424667918
Pubmed

Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.

IKZF2 IKZF1

2.25e-04988222142223
Pubmed

Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.

IKZF3 IKZF1

2.25e-04988219734904
Pubmed

Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos.

IKZF2 IKZF1

2.25e-04988222638570
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR6B1 OR4D10 OR52D1 OR52L1 OR5K2 OR2L13

2.31e-0434088611875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR6B1 OR4D10 OR52D1 OR52L1 OR5K2 OR2L13

2.31e-0434088611802173
Pubmed

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

IKZF3 RPS6KB1 LRRK2 IKZF1 GPR183 IPMK

2.38e-0434288623128233
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR6B1 OR4D10 OR52D1 OR52L1 OR5K2 OR2L13

2.42e-0434388632295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR6B1 OR4D10 OR52D1 OR52L1 OR5K2 OR2L13

2.54e-0434688614611657
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

RAB3GAP2 EEF2K PPFIA3 DOCK6 STT3A

2.63e-0422388533187986
Pubmed

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.

RPS6KB1 EEF2K

2.81e-041088215809305
Pubmed

Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.

VIPR1 SCTR

2.81e-041088215670850
Pubmed

NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

IKZF3 IKZF2 ZBED4 IKZF1

3.31e-0412988423022380
Pubmed

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

IKZF3 IKZF1

3.43e-041188210204490
Pubmed

Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.

IKZF3 CD80

3.43e-041188223000144
Pubmed

Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines.

CD80 ITGAX

3.43e-041188223981064
Pubmed

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

RPS6KB1 EEF2K

3.43e-041188211500364
Pubmed

The human olfactory receptor gene family.

OR6B1 OR4D10 OR52D1 OR52L1 OR5K2 OR14A16 OR1L1

4.54e-0454188714983052
Pubmed

Ikaros confers early temporal competence to mouse retinal progenitor cells.

IKZF2 IKZF1

4.85e-041388218940586
Pubmed

Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.

SRD5A1 MC2R PRLR

5.07e-046188320634197
Pubmed

Protein interactions of the transcription factor Hoxa1.

PCSK5 IKZF2 MGAT5B

5.31e-046288323088713
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

RALGAPA1 ABCC1 IKZF2 ATP6V0A1 RPS6KB1 VPS8 EIF5 RIC8A WDR90

5.60e-0492588928986522
Pubmed

κB-Ras proteins regulate both NF-κB-dependent inflammation and Ral-dependent proliferation.

RALGAPA1 RALGAPA2

5.65e-041488225220458
Pubmed

FoxN1 mediates thymic cortex-medulla differentiation through modifying a developmental pattern based on epithelial tubulogenesis.

CD80 IKZF1

6.51e-041588231552487
Pubmed

The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.

FLNA PTPN13

7.42e-041688218824598
Pubmed

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation.

IKZF3 IKZF1

7.42e-041688230760870
Pubmed

Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.

VIPR1 MC2R SCTR

7.58e-047088312036966
Pubmed

Ikaros SUMOylation: switching out of repression.

IKZF3 IKZF1

8.40e-041788215767674
Pubmed

Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

GARS1 EIF5 CSTF3 RIC8A TAF2 MED12

1.05e-0345488633226137
Pubmed

The G protein-coupled receptor repertoires of human and mouse.

GPR173 SCTR GPR183

1.08e-037988312679517
Pubmed

STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation.

TAF2 MED12

1.17e-032088217967894
Pubmed

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

ZNF224 ZNF225

1.17e-032088212743021
Pubmed

Oxidized thioredoxin-1 restrains the NLRP1 inflammasome.

DPP9 NEK7

1.29e-032188236332009
Pubmed

CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.

BAZ1B ASB4

1.29e-032188222154806
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

RALGAPA1 PTPN13 ATP6V0A1 DPP9 NISCH RAB3GAP2 BAZ1B EEF2K BCKDHA AP3D1 STT3A

1.31e-031487881133957083
Pubmed

Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FLNA DPP9 ITGAX

1.33e-038588315449545
Pubmed

Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.

MAP3K11 STT3A

1.41e-032288215767678
Pubmed

Essential and supporting host cell factors for HIV-1 budding.

FLNA AP3D1

1.55e-032388222004035
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

RALGAPA1 PTPN13 NISCH VPS8 TENM1 DOCK6

1.79e-0350488634432599
Pubmed

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function.

TAF2 MED12

1.83e-032588219240132
Pubmed

Family-based analysis of candidate genes for polycystic ovary syndrome.

SRD5A1 FEM1A

2.13e-032788220200332
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

RALGAPA1 PTPN13 RAB3GAP2 EIF5 AP3D1 MED12 STT3A

2.15e-0370888739231216
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ZBED4 MRC2 PPFIA3

2.24e-031028839734811
Pubmed

The protein kinase complement of the human genome.

POMK RSKR

2.29e-032888212471243
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

ABCC1 PTPN13 TBCD

2.37e-0310488331240132
CoexpressionGSE26669_CTRL_VS_COSTIM_BLOCK_MLR_CD8_TCELL_DN

DCAF15 NISCH LRRK2 IKZF1 ITGAX MED12 TMEM63A

4.73e-06200877M4667
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RHPN1 RAB3GAP2 TENM1 GPR183 ANKRD16 TMEM63A

4.58e-07146886deeb2c90a478deac7805e1f0d1466bf5bc42f746
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRRK2 GLRA3 SCTR ROS1 CADPS2 MGAT5B

1.41e-06177886f902600c639087664316b3cf30cab243bc3d1c5c
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PTPN13 LRRK2 SCTR ROS1 CADPS2 AP3D1

1.88e-06186886acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VIPR1 PTPN13 IKZF2 VPS8 WDR90

2.09e-05168885a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRRK2 GLRA3 ROS1 CADPS2 MGAT5B

2.40e-051738859a2d42f8d9cb834856522661d524abb91c4637c5
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

LRRK2 SCTR ROS1 WDR90 PRLR

2.68e-05177885ac8f774596068e66c0a9ea8a318be0ce5f5df834
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 VIPR1 TENM1 CADPS2 SEMA3E

2.68e-051778854c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

LRRK2 SCTR ROS1 WDR90 PRLR

2.68e-05177885d9c4a93b0e04a13bf39992dd1c1ec8df2c5f89fe
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GLRA3 SCTR ROS1 CADPS2 MGAT5B

2.83e-051798858766a5a066091879f521acfc612abf563ff78808
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

PTPN13 LRRK2 SCTR ROS1 CADPS2

2.90e-05180885198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLNA NALCN MRC2 GPR173 MC2R

2.98e-05181885d7e04e0ca549eac6d9b1192b6578f9b54943d54f
ToppCelldroplet-Tongue-nan-24m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA1A CD80 DNAH2 GPR183 ITGAX

3.06e-051828850f06309318c064f0ebdb12a46226b90032290137
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IKZF3 CD80 GLRA3 GPR183 FAM111B

3.14e-05183885ffa831f67ed005f05d1b80ebc707e046fc08e22f
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PTPN13 LRRK2 SCTR ROS1 CADPS2

3.14e-051838856847c1252d6bb105524f812658112517fd351eab
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

PTPN13 LRRK2 SCTR ROS1 CADPS2

3.14e-051838858e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

PTPN13 LRRK2 SCTR ROS1 CADPS2

3.22e-05184885369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

RHPN1 PTPN13 CHSY3 CADPS2 SEMA3E

3.22e-05184885102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCellIPF-Epithelial-ATII|IPF / Disease state, Lineage and Cell class

PTPN13 LRRK2 SCTR ROS1 CADPS2

3.31e-05185885563b4e6d92bb5d77a3829556116a8e99aebac615
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RHPN1 PRODH2 KCNJ13 GLRA3 ANKRD16

3.31e-05185885d42f6722a6771752cd744146a09e2ead9b7252bc
ToppCellIPF-Epithelial-ATII|World / Disease state, Lineage and Cell class

PTPN13 LRRK2 SCTR ROS1 CADPS2

3.40e-051868856a4ff2da0af0f5e590d9f9daa5b5e9ac8c868947
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

PTPN13 LRRK2 CHSY3 ROS1 CADPS2

3.48e-0518788581cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

PTPN13 LRRK2 SCTR ROS1 CADPS2

3.57e-05188885ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

PTPN13 LRRK2 SCTR ROS1 CADPS2

3.66e-05189885dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellCOVID-19-Endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

VIPR1 PLA1A CADPS2 RALGAPA2 DOCK6

3.76e-051908859fbd92cd6d4683b2490504d29c43cf42020433d4
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|World / Sample and Cell Type and Tumor Cluster (all cells)

CD80 LRRK2 IKZF1 GPR183 ITGAX

3.85e-051918853b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

PTPN13 LRRK2 SCTR ROS1 CADPS2

3.85e-05191885a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-Th17|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IKZF3 PTPN13 IKZF1 GPR183 SESN1

3.85e-05191885b3ed4797a7a9810cf3507e0d0f23f45c35bd8ba2
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

PTPN13 LRRK2 SCTR ROS1 CADPS2

3.95e-0519288558c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PTPN13 LRRK2 SCTR ROS1 CADPS2

3.95e-05192885fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PTPN13 LRRK2 SCTR ROS1 CADPS2

4.05e-05193885fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

PTPN13 LRRK2 SCTR ROS1 CADPS2

4.05e-05193885738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PTPN13 LRRK2 SCTR ROS1 CADPS2

4.05e-05193885f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

CD80 LRRK2 IKZF1 GPR183 ITGAX

4.25e-05195885ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PTPN13 MRC2 LRRK2 ROS1 PRLR

4.36e-051968857e5addaa844e66f8160e05858c341866a80aed23
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

VIPR1 NISCH GPR183 SESN1 PRLR

4.36e-05196885e8c4eeb4b6c6d9bccca2adb942d4cfbaab39636c
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PTPN13 MRC2 LRRK2 ROS1 PRLR

4.46e-05197885bf10727fbe90b71d2ac60a11711e5f0701b3799d
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PTPN13 LRRK2 SCTR ROS1 CADPS2

4.57e-05198885f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellCOVID-19-lung-Capillary_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

VIPR1 PLA1A CADPS2 RALGAPA2 DOCK6

4.57e-0519888545419f2804b4be79bae6632e71c54e1af482d115
ToppCellASK428-Epithelial-Type_2|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

PTPN13 LRRK2 SCTR ROS1 CADPS2

4.57e-05198885ec0d1801363adb70c6a26655b79d12b438c7417d
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PTPN13 LRRK2 SCTR ROS1 CADPS2

4.57e-051988852e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PTPN13 PLA1A LRRK2 ROS1 CADPS2

4.57e-05198885aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCellbackground-Hepatic_Stellate_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

PCSK5 VIPR1 PTPN13 NALCN CHSY3

4.57e-05198885bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCelldroplet-Marrow-nan-21m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIPR1 CD80 MED12 TRUB2

9.14e-05119884aa3860c8d25c85baa79a0b6637bce2e269adfcc2
ToppCellLPS-IL1RA-Hematopoietic_Mast-Mast_cells-Mast-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCC1 PRODH2 IKZF1 GPR183

1.66e-04139884f1d1a51a79afdddc82e73cd29b3240e3e973db28
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-T-cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IKZF3 IKZF2 IKZF1 ITGAX

1.66e-04139884ecc2a6ecc27748c50885cd4f0ad8a8cd1252aee6
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCC1 CD80 IKZF1 ITGAX

2.01e-04146884b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCellControl-B_intermediate-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FLNA LRRK2 GPR183 ITGAX

2.12e-04148884662c057030effc9eb61216e81d3967e6983c244f
ToppCellP28-Hematopoietic-Immune-immune_cell_unspecified|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

IKZF3 IKZF1 GPR183 ITGAX

2.65e-04157884a70f93aff07b6b7a9efce33b12b024116648dc0a
ToppCellP28-Hematopoietic-Immune|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

IKZF3 IKZF1 GPR183 ITGAX

2.65e-04157884b1f520b1e0ea7abb19d0dd27021eafbea0fd90cd
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN13 IKZF2 GPR183 SEMA3E

2.92e-04161884140b3c7077947c541cff54f6754e2df968345f4d
ToppCell356C-Epithelial_cells-Epithelial-C_(AT2)-|356C / Donor, Lineage, Cell class and subclass (all cells)

VIPR1 PTPN13 LRRK2 SCTR

2.92e-0416188478cb72c462167021195917a06052bcdc367ad890
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GPR173 KCNJ13 TENM1 TBCD

2.92e-04161884d72c572613f8eff3251cb7b1e9dcc76d193b2f21
ToppCell356C-Epithelial_cells-Epithelial-C_(AT2)|356C / Donor, Lineage, Cell class and subclass (all cells)

VIPR1 PTPN13 LRRK2 SCTR

2.92e-0416188406e7becfd11d6ef1a45a9cfdfcb40b812600038e
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZAN TENM1 ROS1 PRLR

2.98e-04162884bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIPR1 IKZF3 IKZF1 ITGAX

2.98e-041628840321fc954ae4ad67ca438cbbc84632562d222188
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN13 IKZF2 GPR183 SEMA3E

2.98e-0416288416f9fbcaa0093ffc5a2a5e32db6040e2cb519d47
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIPR1 IKZF3 IKZF1 ITGAX

2.98e-041628845731f9514434296132df4bc86f78ce87b07cdeca
ToppCelldroplet-Bladder-nan-3m-Hematologic-leukocyte|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD80 IKZF1 GPR183 ITGAX

3.06e-041638842f32a9ab0230fdca98ffa7fd59397301d50e4f30
ToppCelldroplet-Bladder-nan-3m-Hematologic|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD80 IKZF1 GPR183 ITGAX

3.06e-041638846c2967dee563295febe2adabf503d095cb911ccf
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IKZF3 IKZF2 TAF2 SESN1

3.13e-0416488474bf6080abd9191e3db8ee892fce84f1dcc4b775
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 MRC2 ROS1 SEMA3E

3.20e-04165884e381bcd558745f3a60346f78b49d0b2672184baa
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IKZF3 PLA1A IKZF1 GPR183

3.20e-041658840c80abf13409767825ef8a507b498afafa7e89c5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 MRC2 ROS1 SEMA3E

3.20e-04165884fee7f2f8d0e25c0d067adc73f8913721bd709a3e
ToppCellPND01-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IKZF3 IKZF1 GPR183 POMK

3.20e-0416588466f0364098d82629aa2ec1dfe0c5ad23de7c2c12
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IKZF3 PLA1A IKZF1 GPR183

3.20e-04165884cced77f2d74b07010307d7f4788b8cf3fdaeb91a
ToppCellMild/Remission-B_memory-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FLNA CD80 GPR183 ITGAX

3.27e-0416688403e1a369d8a83b814def07e29cabb023226b4828
ToppCelldroplet-Bladder-nan-3m-Hematologic-granulocyte-monocyte_progenitor|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD80 IKZF1 GPR183 ITGAX

3.27e-04166884e01c720de6d4ca144c55378e023e718a64bf32f6
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PTPN13 LRRK2 CHSY3 CADPS2

3.27e-04166884c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 MRC2 ROS1 SEMA3E

3.27e-04166884739dfbe927f409821ff23aca6e47ebe78f57e859
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 TENM1 ROS1 SEMA3E

3.35e-04167884a6ff7a3d9b80839c0efa91658836812e868561fa
ToppCellSevere-B_memory-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FLNA CD80 GPR183 ITGAX

3.43e-0416888485a36e1b994a8fd2f589563f011913e4944dc1cd
ToppCelldroplet-Fat-Scat-21m-Lymphocytic-T_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRODH2 IKZF3 IKZF2 GPR183

3.43e-0416888499343f7a76ff70a2252c365d527f9c8ae16b8571
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZBED4 EEF2K MED12 STT3A

3.43e-04168884ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 VIPR1 TENM1 SEMA3E

3.43e-041688847abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_ETV4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 VIPR1 ROS1 SEMA3E

3.50e-04169884ccb7b2daa65cb5f4c1e7a48b3bcdf0cb8f7675c3
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l15|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD80 IKZF1 GPR183 ITGAX

3.66e-0417188487cb65648c663e246f94cea1a5ed12e8e29ec629
ToppCelldroplet-Trachea-nan-3m-Myeloid-macrophage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD80 IKZF1 GPR183 ITGAX

3.75e-04172884f6c00a6a7e81aaf96c55eb3a3c88e3719f102ea0
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GLRA3 ROS1 SEMA3E

3.75e-04172884adc09c4d1b63fe84150516beb692db1e7f7ac980
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-tracheal_macrophage|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD80 IKZF1 GPR183 ITGAX

3.75e-04172884f3bbe3f069ad070778430d1a6cd9db0a76deb8de
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

VIPR1 ABCC1 GPR173 FAM111B

3.75e-0417288494093d356b0252b440deda4e1b0ac332b31513f6
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-iNKT-MAIT|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IKZF3 IKZF2 IKZF1 ITGAX

3.83e-04173884fde1fabb8d13d05998ac3f21ecb1fde6a7a2f337
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF3 PTPN13 WDR90 ANKRD16

3.83e-041738846e92983d9f8a2a37f23e60a0d5bb1738217897bc
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IKZF3 IKZF2 IKZF1 ITGAX

3.83e-04173884dcde3252ff96448d3a61039a4948c74ad321a218
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-Alox5+_Lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IKZF3 PTPN13 WDR90 ANKRD16

3.83e-041738844c788c1dad1da495b3b5c10f95e779848dfe85dc
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IKZF3 LRRK2 ROS1 CADPS2

3.91e-04174884ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 TENM1 ROS1 SEMA3E

3.91e-04174884e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCellLPS-antiTNF-Lymphocytic_NKT-iNKT/MAIT|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IKZF3 IKZF2 IKZF1 ITGAX

3.91e-0417488461aa89b56ebda0eba1ba675d5f036992967f670f
ToppCellwk_15-18-Hematologic-Myeloid-aDC_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PLA1A CD80 GPR183 ITGAX

4.00e-04175884c31178d7a5a19d7afd336c9ec0e5c493655a6aa4
ToppCellLPS-antiTNF-Lymphocytic_NKT-iNKT/MAIT-iNKT-MAIT|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IKZF3 IKZF2 IKZF1 ITGAX

4.00e-0417588498cb577df466700e72d1bbc6689205ccf2e7fcba
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRRK2 GLRA3 ROS1 CADPS2

4.08e-0417688440993c41c1017b53039a337174fc56632b278609
ToppCellfacs-SCAT-Fat-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIPR1 IKZF3 TENM1 IKZF1

4.17e-04177884ffc4c675b25ffe8bd3441ce26dd0984fef4b3b88
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CD80 MRC2 GPR183 ITGAX

4.17e-04177884f28243b51be104cb3adcde63f03fc2206ed3121e
ToppCellMild/Remission-B_memory-6|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FLNA CD80 GPR183 ITGAX

4.17e-041778848f2ce5ffc94ca90412cb6899629f322dc778215c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 TENM1 CADPS2 SEMA3E

4.17e-04177884bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCell3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-cDC2|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CD80 IKZF1 GPR183 ITGAX

4.26e-041788848184a2b9872f7ca12a9823535de485e841aeffb1
ToppCellLPS_only-Lymphocytic_NKT-iNKT/MAIT|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IKZF3 IKZF2 IKZF1 ITGAX

4.35e-04179884de3ddc1264e43727be50d69b81cc84a3c91812a2
ToppCellBAL-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

VPS8 LRRK2 BAZ1B TRUB2

4.35e-0417988468511e87b12b8253de7771e5ccfc5869248b8450
ToppCellLPS_only-Lymphocytic_NKT-iNKT/MAIT-iNKT-MAIT|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IKZF3 IKZF2 IKZF1 ITGAX

4.35e-04179884def981e97e3ff9019910c9af3861ca0d08eb0d0f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 TENM1 CADPS2 SEMA3E

4.35e-041798847954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LRRK2 IKZF1 GPR183 ITGAX

4.35e-041798849fc44637c9a7551fd47b8533e45a9c199e164a95
DrugmV GABA

GARS1 GLRA3 MED12

1.11e-066883CID000128435
DiseaseFG syndrome (is_implicated_in)

FLNA MED12

2.46e-053852DOID:14711 (is_implicated_in)
DiseaseFG SYNDROME 4 (disorder)

FLNA MED12

2.46e-053852C1845546
DiseaseFG SYNDROME 2

FLNA MED12

2.46e-053852C1845902
DiseaseFG SYNDROME 3

FLNA MED12

2.46e-053852C1845567
DiseaseFG syndrome

FLNA MED12

2.46e-053852C0220769
DiseaseFG syndrome

FLNA MED12

4.90e-054852cv:C0220769
DiseasePhyllodes Tumor

FLNA MED12

8.15e-055852C0010701
DiseaseMalignant Cystosarcoma Phyllodes

FLNA MED12

8.15e-055852C0600066
DiseaseL2 Acute Lymphoblastic Leukemia

IKZF3 IKZF2 IKZF1

4.10e-0450853C0023453
DiseaseChildhood Acute Lymphoblastic Leukemia

IKZF3 IKZF2 IKZF1

4.60e-0452853C0023452
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

IKZF3 IKZF2 IKZF1

7.36e-0461853C1961102
DiseaseGastro-enteropancreatic neuroendocrine tumor

IKZF3 IKZF1

8.40e-0415852C2930967
Diseaseinflammatory bowel disease

PCSK5 IKZF3 LRRK2 IKZF1 GPR183 IPMK

1.91e-03449856EFO_0003767
Diseaselung adenocarcinoma (is_marker_for)

PTPN13 EEF2K IKZF1

1.92e-0385853DOID:3910 (is_marker_for)
DiseaseOvarian Serous Adenocarcinoma

LRRK2 NEK7

1.99e-0323852C1335177
DiseaseCFTR mutation carrier status

PCSK5 NEK7

2.36e-0325852EFO_0021794

Protein segments in the cluster

PeptideGeneStartEntry
HEAASMGHRDCVRYL

ANKRD16

76

Q6P6B7
EYSTEHHLVCRMLLD

ASB4

226

Q9Y574
ALCHRILMTYSVQDH

BAZ1B

751

Q9UIG0
IEHPYHTHICRGAMF

C7orf31

146

Q8N865
NHSFMCLIKYGHLRV

CD80

211

P33681
MYSRSIQGHHVCLLV

AP3D1

1106

O14617
YSRCLELMLTHVARH

PRODH2

411

Q9UF12
THCRLHTPMYIFLGN

OR5K2

51

Q8NHB8
MAHVRHFRTLVSGFY

GLRA3

1

O75311
TVHHECGRNMYLTGL

ITGAX

111

P20702
EHHSILCSILYAVMR

RAB3GAP2

1156

Q9H2M9
VMTHTYCEHMGIARL

OR52D1

176

Q9H346
SFHRVSLHYGIMCLK

PPFIA3

1001

O75145
TCEGMLERIHAYIQH

MGAT5B

626

Q3V5L5
YIPLMEFSCSHSHLV

PCNX4

896

Q63HM2
HSVHVCTRCMKGYFI

PCSK5

996

Q92824
YFVQLCSALEHMHSR

NEK7

141

Q8TDX7
VMFAYEQCLLVLGHH

CSTF3

276

Q12996
TSYLPSEIMLHHCFA

KCNJ13

286

O60928
CFYLAEISMALGHLH

RPS6KB1

196

P23443
VLCYLHDLGIMHRDV

RSKR

216

Q96LW2
LHVADGLRYLHSAMI

LRRK2

1976

Q5S007
IPFREHCYSFHMELL

MRC2

1271

Q9UBG0
CELIRHDVFSHNMYT

MED12

601

Q93074
HCRVLFLDHVMYTIH

IKZF1

466

Q13422
VIYLFLTVGFMRHHT

TMEM63A

201

O94886
LVHFYLVMHLGLTSE

RALGAPA2

1036

Q2PPJ7
CRVLFLDHVMYTIHM

IKZF2

476

Q9UKS7
FLVLGMRVYHVHSDS

IPMK

176

Q8NFU5
ICNPFHYITIMSHRC

OR1L1

176

Q8NH94
HYITIMSHRCCVLLL

OR1L1

181

Q8NH94
QRYLLHGLECVVAMH

EIF5

311

P55010
RMEFTRILCSHEHYV

DOCK6

1041

Q96HP0
FHFHTRSDVRLYGMI

DPP9

611

Q86TI2
HTYCIRFVPAEMGTH

FLNA

2196

P21333
HTCLMISCYKGHREI

FEM1A

151

Q9BSK4
VRGCHRHLCYLAELM

CADPS2

686

Q86UW7
CISVTRYMAIAHHRF

GPR173

116

Q9NS66
VHLAMVRYHEGGRFC

EEF2K

526

O00418
NGGYIFTCRHVVHLM

FAM111B

481

Q6SJ93
HCRVLFLDYVMFTIH

IKZF3

456

Q9UKT9
MSDYLRILEHAIHFG

DNAH2

3421

Q9P225
AGVLHMLYCVLFHGT

SCAPER

1181

Q9BY12
CLRHGFMLHTKYQVV

DCAF15

211

Q66K64
QIARGMHYLHCEALV

MAP3K11

221

Q16584
FISYMRHIHRSGPII

PTPN13

2391

Q12923
MPVHYGCKERHFVTI

BCKDHA

191

P12694
HPLHYDVIMDRSTCV

OR14A16

126

Q8NHC5
SCGRVLFAVYHMHSK

OR2L13

216

Q8N349
HAHEIGYIVCLIQMF

OR52L1

106

Q8NGH7
HYATIMSRDHCIGLT

OR4D10

131

Q8NGI6
LHQYFHICFVSGMRI

ABCC1

381

P33527
RHGMHVPTFRVQDYC

SESN1

341

Q9Y6P5
ILVDPYMHEVTHFCL

TAF2

256

Q6P1X5
CDLYAHHSTARIVMP

GPR183

21

P32249
LGRIMYTVFEHTFHV

GARS1

581

P41250
MFLHYYSDRSGLCHI

GUCY1B2

51

O75343
GLMITSAAIYHVLHF

STT3A

91

P46977
TIHLMHDGFICTIRY

TENM1

2001

Q9UKZ4
VSGHQLTHGLLCYEM

SH3TC2

931

Q8TF17
LCYEMALLFGLRHRH

SH3TC2

941

Q8TF17
MADEIIVFSCGHLYH

VPS8

1271

Q8N3P4
YLHHSPVGTRVMCDS

POMK

191

Q9H5K3
HYPTIMSHGLCFRLA

OR6B1

131

O95007
ALYRHLGTLLRHCVM

RIC8A

246

Q9NPQ8
FRSLAHYHVAMALCD

RHPN1

351

Q8TCX5
CLYVHMFLLARSHTR

MC2R

191

Q01718
VPHIGECLREMYTTH

CHSY3

326

Q70JA7
AGYSYLICDHMRAVH

PLA1A

251

Q53H76
LICDHMRAVHLYISA

PLA1A

256

Q53H76
YIHMHLFISFILRAA

VIPR1

176

P32241
HLGFLDTLSRVYHML

WDR90

681

Q96KV7
RDFLTHFYNIMHCGL

RALGAPA1

1166

Q6GYQ0
YIHMHLFVSFILRAL

SCTR

176

P47872
DSYLTHCFLQHLMVV

NISCH

1261

Q9Y2I1
SLTYHREGETLMHEC

PRLR

61

P16471
CHHVMIEAVGYLYRS

TTC41P

1061

Q6P2S7
GCVYLERMHFIHRDL

ROS1

2066

P08922
MHGRAYLLLHRDFCD

UBE2U

1

Q5VVX9
EMAFRYHCQLIEHSR

ZNF780A

451

O75290
CYSSALRIHQRVHMG

ZNF225

186

Q9UK10
TMVHQAIHTIEYCLG

ATP6V0A1

716

Q93050
ILLAMFLVHYGHRCL

SRD5A1

86

P18405
FRGHAICVYHMSSIR

SEMA3E

336

O15041
HMRHGSILACAEVAY

TBCD

616

Q9BTW9
HGCRLLTDMYNAHLT

TRUB2

111

O95900
CYISALRIHQRVHMG

ZNF224

186

Q9NZL3
KGFICRRDLYTHHMV

ZNF224

351

Q9NZL3
ECFLGSIHRDHRYRM

UBR2

126

Q8IWV8
MHQRIHTGERSYICT

ZNF81

431

P51508
ALHHFMGTCTYVLTR

ZAN

1556

Q9Y493
DVGTSCLMRHLYRRH

ZBED4

491

O75132
IHGIYIHVFVFLGCM

NALCN

1131

Q8IZF0