Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessnegative regulation of cyclin-dependent protein serine/threonine kinase activity

HEXIM1 HEXIM2 LATS1 LATS2

1.37e-05291054GO:0045736
GeneOntologyBiologicalProcessnegative regulation of cyclin-dependent protein kinase activity

HEXIM1 HEXIM2 LATS1 LATS2

1.57e-05301054GO:1904030
GeneOntologyBiologicalProcessinner cell mass cell fate commitment

LATS1 LATS2

7.68e-0531052GO:0001827
GeneOntologyBiologicalProcessinner cell mass cellular morphogenesis

LATS1 LATS2

7.68e-0531052GO:0001828
DomainHEXIM

HEXIM1 HEXIM2

3.07e-0521042IPR024872
DomainHEXIM

HEXIM1 HEXIM2

3.07e-0521042PF15313
DomainGlyco_hydro_15

PHKA1 PHKB

9.18e-0531042PF00723
DomainGlyco_hydro_15/PHK

PHKA1 PHKB

9.18e-0531042IPR011613
DomainPHK_A/B_su

PHKA1 PHKB

9.18e-0531042IPR008734
DomainMABP

DENND4A MVB12B

1.83e-0441042IPR023341
DomainMABP

DENND4A MVB12B

1.83e-0441042PS51498
DomainDUF4704

NBEAL1 WDFY3

3.04e-0451042IPR031570
DomainDUF4704

NBEAL1 WDFY3

3.04e-0451042PF15787
DomainNa_trans_cytopl

SCN1A SCN9A

4.54e-0461042PF11933
DomainPH_BEACH

NBEAL1 WDFY3

4.54e-0461042PF14844
DomainNa_trans_cytopl

SCN1A SCN9A

4.54e-0461042IPR024583
DomainIQ

SCN1A MYO1F SCN9A CAMTA1

6.62e-04711044PF00612
DomainPH-BEACH_dom

NBEAL1 WDFY3

8.41e-0481042IPR023362
Domain-

NBEAL1 WDFY3

8.41e-04810422.30.29.40
DomainDHC_N1

DNAH10 DNAH2

8.41e-0481042PF08385
DomainPH_BEACH

NBEAL1 WDFY3

8.41e-0481042PS51783
DomainDynein_heavy_dom-1

DNAH10 DNAH2

8.41e-0481042IPR013594
DomainUBA

UBAP2 LATS1 LATS2

1.05e-03361043PF00627
DomainBEACH_dom

NBEAL1 WDFY3

1.08e-0391042IPR000409
DomainBEACH

NBEAL1 WDFY3

1.08e-0391042PS50197
DomainBeach

NBEAL1 WDFY3

1.08e-0391042PF02138
Domain-

NBEAL1 WDFY3

1.08e-03910421.10.1540.10
DomainBeach

NBEAL1 WDFY3

1.08e-0391042SM01026
DomainIQ

SCN1A MYO1F SCN9A CAMTA1

1.09e-03811044SM00015
DomainNa_channel_asu

SCN1A SCN9A

1.34e-03101042IPR001696
DomainNa_trans_assoc

SCN1A SCN9A

1.34e-03101042IPR010526
DomainNa_trans_assoc

SCN1A SCN9A

1.34e-03101042PF06512
DomainIQ_motif_EF-hand-BS

SCN1A MYO1F SCN9A CAMTA1

1.61e-03901044IPR000048
DomainIQ

SCN1A MYO1F SCN9A CAMTA1

1.81e-03931044PS50096
DomainUBA

UBAP2 LATS1 LATS2

1.88e-03441043IPR015940
DomainUBA

UBAP2 LATS1 LATS2

2.28e-03471043PS50030
Domain6-hairpin_glycosidase-like

PHKA1 PHKB

2.30e-03131042IPR008928
DomainDynein_heavy_chain_D4_dom

DNAH10 DNAH2

2.68e-03141042IPR024317
DomainDynein_HC_stalk

DNAH10 DNAH2

2.68e-03141042IPR024743
DomainMyotubularin-like_Pase_dom

MTMR8 MTMR7

2.68e-03141042IPR010569
DomainDynein_heavy_dom-2

DNAH10 DNAH2

2.68e-03141042IPR013602
DomainDHC_N2

DNAH10 DNAH2

2.68e-03141042PF08393
DomainMT

DNAH10 DNAH2

2.68e-03141042PF12777
DomainAAA_8

DNAH10 DNAH2

2.68e-03141042PF12780
DomainPPASE_MYOTUBULARIN

MTMR8 MTMR7

2.68e-03141042PS51339
DomainATPase_dyneun-rel_AAA

DNAH10 DNAH2

2.68e-03141042IPR011704
DomainMyotubularin_fam

MTMR8 MTMR7

2.68e-03141042IPR030564
DomainMyotub-related

MTMR8 MTMR7

2.68e-03141042PF06602
DomainAAA_5

DNAH10 DNAH2

2.68e-03141042PF07728
DomainDHC_fam

DNAH10 DNAH2

3.08e-03151042IPR026983
DomainDynein_heavy_dom

DNAH10 DNAH2

3.08e-03151042IPR004273
DomainDynein_heavy

DNAH10 DNAH2

3.08e-03151042PF03028
DomainAGC-kinase_C

LATS1 LATS2 MASTL

3.75e-03561043IPR000961
DomainAGC_KINASE_CTER

LATS1 LATS2 MASTL

3.75e-03561043PS51285
DomainS_TK_X

LATS1 LATS2 MASTL

3.75e-03561043SM00133
Domain-

SEMA3G PKHD1L1 LILRB1 KIRREL3 LRFN5 ATF7IP CAMTA1 SDK1 PALLD CD96

3.87e-03663104102.60.40.10
DomainChannel_four-helix_dom

TPTE2 SCN1A SCN9A

3.95e-03571043IPR027359
Domain-

TPTE2 SCN1A SCN9A

3.95e-035710431.20.120.350
DomainUBA-like

UBAP2 LATS1 LATS2

5.46e-03641043IPR009060
Pubmed

Human transcription factor protein interaction networks.

NCOA2 TET2 UBAP2 ERG COPA DNAH10 SEC24A ETV3 LARP1 C15orf39 DARS1 ZHX2 ANKHD1 HEXIM2 HMG20A ARID1B PRRC2C ATF7IP ANKRD17 UNK SUFU

2.70e-0914291082135140242
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

NCOA2 ABCF3 COPA WDR70 LARP1 DARS1 ECPAS ANKHD1 HEXIM2 TTLL7 CRACD PRRC2C MAPKAPK3 ANKRD17 SUFU TOP3B

9.91e-098571081625609649
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

COPA LARP1 MED1 ECPAS PHKB MSH6 PRRC2C ANKRD17 TOP3B

1.50e-08202108933005030
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

UBAP2 DSG1 TCOF1 DLGAP5 WDR70 LARP1 DARS1 MED1 ANKHD1 CRACD MSH6 PRRC2C ATF7IP MASTL ANKRD17 PALLD

3.27e-089341081633916271
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

UBAP2 ABCF3 HYOU1 COPA DSG1 LARP1 DARS1 MED1 ANKHD1 PRRC2C ANKRD17 UNK TOP3B PALLD

5.84e-087241081436232890
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ERG COPA TCOF1 NELFA DLGAP5 LARP1 MED1 ECPAS TERF2IP HEXIM2 MSH6 LATS1 ANKRD17 UNK

1.32e-077741081415302935
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

HYOU1 TCOF1 SPRR3 TPTE2 WDR70 MTMR8 GRB2 ECPAS ANKHD1 ABRAXAS2 TXNL1 MSH6 MTMR7 ANKRD17 SUFU

3.56e-079741081528675297
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

DNAH10 TPTE2 MTMR8 DNAH2 GRB2 BIRC2 SEMA3G MTMR7 ARID1B TTBK1 LATS1 LATS2 MMP8

4.56e-077301081334857952
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

UBAP2 TCOF1 NELFA GRB2 LARP1 DARS1 HEXIM1 ABRAXAS2 ARID1B PRRC2C ANKRD17 PALLD

5.01e-076151081231048545
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TET2 UBAP2 DLGAP5 SERTAD2 LARP1 SPIRE1 ECPAS ANKHD1 ARID1B ANKRD17 UNK

8.31e-075291081114621295
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

HYOU1 COPA SEC24A TPTE2 MTMR8 GRB2 C2CD4C ABRAXAS2 PHKA1 PHKB MSH6 MTMR7 ARID1B SUFU TOP3B

9.01e-0710491081527880917
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

NCOA2 UBAP2 TCOF1 LARP1 MED1 ANKHD1 MSH6 ARID1B LATS1 PRRC2C PALLD

1.19e-065491081138280479
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

NCOA2 VPS37A ABCF3 NELFA WDR70 LARP1 MED1 ZHX2 MASTL PALLD

1.32e-064441081034795231
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

NCOA2 TET2 HYOU1 NELFA GRB2 LARP1 C15orf39 DARS1 MED1 ECPAS HEXIM1 TXNL1 MSH6 ARID1B PRRC2C

1.68e-0611031081534189442
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

NCOA2 TET2 NELFA ETV3 MED1 HEXIM1 TXNL1 ARID1B

2.03e-06268108833640491
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

HYOU1 COPA TCOF1 SEC24A LARP1 DARS1 ECPAS TXNL1 LATS1 PRRC2C ANKRD17 PALLD

2.17e-067081081239231216
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

NCOA2 ZNF793 VPS37A SLC31A1 WDR70 LARP1 SPIRE1 ECPAS ZHX2 TERF2IP HEXIM2 PHKB UBE2J2 LATS2 ANKRD17 PLA2G6 CAMTA1

3.42e-0614891081728611215
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

COPA TCOF1 NELFA DLGAP5 LARP1 MED1 TERF2IP MSH6 MASTL PALLD

4.00e-065031081016964243
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

NCOA2 TET2 GRB2 LARP1 C15orf39 ZHX2 ARID1B ATF7IP SUFU

4.44e-06398108935016035
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

UBAP2 TCOF1 GRB2 LARP1 MED1 ZHX2 TERF2IP PRRC2C PALLD

4.53e-06399108935987950
Pubmed

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.

UBAP2 ABCF3 LARP1 ECPAS TXNL1 PRRC2C ANKRD17

5.30e-06216108731519766
Pubmed

Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.

HYOU1 COPA DSG1 GRB2 TXNL1 MASTL PALLD

6.92e-06225108731478661
Pubmed

Inhibition of Tat activity by the HEXIM1 protein.

HEXIM1 HEXIM2

9.55e-062108215992410
Pubmed

Association analysis between SNPs in LATS1 and LATS2 and non-cardia gastric cancer.

LATS1 LATS2

9.55e-062108232423384
Pubmed

Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma.

LATS1 LATS2

9.55e-062108234060480
Pubmed

Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer.

LATS1 LATS2

9.55e-062108225482410
Pubmed

Lats1/2-Mediated Alteration of Hippo Signaling Pathway Regulates the Fate of Bone Marrow-Derived Mesenchymal Stem Cells.

LATS1 LATS2

9.55e-062108230671453
Pubmed

Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.

LATS1 LATS2

9.55e-062108217049657
Pubmed

Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance.

LATS1 LATS2

9.55e-062108231268774
Pubmed

Isoform diversity of phosphorylase kinase alpha and beta subunits generated by alternative RNA splicing.

PHKA1 PHKB

9.55e-06210821874721
Pubmed

Rapid P-TEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy.

HEXIM1 HEXIM2

9.55e-062108238816355
Pubmed

A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis.

LATS1 LATS2

9.55e-062108232826458
Pubmed

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.

LATS1 LATS2

9.55e-062108229730476
Pubmed

The Hippo pathway regulates human megakaryocytic differentiation.

LATS1 LATS2

9.55e-062108227786336
Pubmed

N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability.

LATS1 LATS2

9.55e-062108223230145
Pubmed

TET2 and LILRB1 mutations are frequent in Epstein-Barr virus-positive diffuse large B-cell lymphoma especially in elderly patients.

TET2 LILRB1

9.55e-062108236812290
Pubmed

Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review.

NCOA2 ETV3

9.55e-062108229877893
Pubmed

Cell type-dependent function of LATS1/2 in cancer cell growth.

LATS1 LATS2

9.55e-062108230531839
Pubmed

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.

LATS1 LATS2

9.55e-062108215746036
Pubmed

Natural killer cell profiles in recurrent pregnancy loss: Increased expression and positive associations with TACTILE and LILRB1.

LILRB1 CD96

9.55e-062108236004818
Pubmed

Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray.

LATS1 LATS2

9.55e-062108219799973
Pubmed

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.

LATS1 LATS2

9.55e-062108231848340
Pubmed

Expression of LATS family proteins in ovarian tumors and its significance.

LATS1 LATS2

9.55e-062108225841306
Pubmed

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.

LATS1 LATS2

9.55e-062108232015438
Pubmed

A novel immuno-competitive capture mass spectrometry strategy for protein-protein interaction profiling reveals that LATS kinases regulate HCV replication through NS5A phosphorylation.

LATS1 LATS2

9.55e-062108225044019
Pubmed

Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.

LATS1 LATS2

9.55e-062108224026096
Pubmed

The transcription-dependent dissociation of P-TEFb-HEXIM1-7SK RNA relies upon formation of hnRNP-7SK RNA complexes.

HEXIM1 HEXIM2

9.55e-062108217709395
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

DENND4A NELFA LARP1 ECPAS ABRAXAS2 ARID1B LATS1 LATS2 UNK

1.10e-05446108924255178
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

NCOA2 SEC24A WDR70 ANKHD1 NDUFB4 TXNL1 ARID1B PRRC2C ANKRD17

1.34e-05457108932344865
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

UBAP2 TCOF1 DLGAP5 LARP1 TXNL1 PRRC2C ANKRD17

1.60e-05256108733397691
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

COPA DSG1 WDR70 PHKA1 PHKB PRRC2C SCN9A UNK TOP3B

1.82e-05475108931040226
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

UBAP2 ANKHD1 PRRC2C ANKRD17 TOP3B

2.17e-05107108530995489
Pubmed

Lost in transcription: molecular mechanisms that control HIV latency.

NELFA HEXIM1 HEXIM2

2.72e-0519108323518577
Pubmed

TDP-43 enhances translation of specific mRNAs linked to neurodegenerative disease.

DENND4A CAMTA1

2.86e-053108230357366
Pubmed

A FUS-LATS1/2 Axis Inhibits Hepatocellular Carcinoma Progression via Activating Hippo Pathway.

LATS1 LATS2

2.86e-053108230308519
Pubmed

[Misregulation of P-TEFb activity: pathological consequences].

HEXIM1 HEXIM2

2.86e-053108222377309
Pubmed

Coactivators for the orphan nuclear receptor RORalpha.

NCOA2 MED1

2.86e-053108210478845
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN9A

2.86e-053108233895391
Pubmed

The myotubularin family: from genetic disease to phosphoinositide metabolism.

MTMR8 MTMR7

2.86e-053108211275328
Pubmed

Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.

LATS1 LATS2

2.86e-053108224012335
Pubmed

Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase.

PHKA1 PHKB

2.86e-053108212876330
Pubmed

Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction.

SPRR3 ITGA1

2.86e-053108218832573
Pubmed

Assignment of human genes for phosphorylase kinase subunits alpha (PHKA) to Xq12-q13 and beta (PHKB) to 16q12-q13.

PHKA1 PHKB

2.86e-05310822757032
Pubmed

Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability.

ANKHD1 ANKRD17

2.86e-053108231661072
Pubmed

Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.

HEXIM1 HEXIM2

2.86e-053108215965233
Pubmed

Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway.

LATS1 LATS2

2.86e-053108218413746
Pubmed

Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure.

PHKA1 PHKB

2.86e-053108210487978
Pubmed

Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster.

ZHX2 ARID1B

2.86e-053108216952470
Pubmed

Tumor suppressor LATS1 is a negative regulator of oncogene YAP.

LATS1 LATS2

2.86e-053108218158288
Pubmed

LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells.

LATS1 LATS2

2.86e-053108235859006
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

ABCF3 HYOU1 COPA DSG1 TCOF1 SEC24A GRB2 LARP1 DARS1 ANKHD1 HEXIM1 TXNL1 MSH6 PRRC2C PALLD

3.23e-0514151081528515276
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

SEMA3G FZD8 SLITRK2 LRFN5 SDK1

3.34e-05117108517145500
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

TET2 DSG1 TCOF1 ETV3 LARP1 DARS1 ANKHD1 MSH6 PRRC2C ANKRD17

3.88e-056551081035819319
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HEXA WDR70 MTMR8 RAP1GAP2 C15orf39 SPIRE1 ANKHD1 LATS2 PLA2G6 WDFY3 SUFU TOP3B MVB12B

3.96e-0511051081335748872
Pubmed

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.

UBAP2 TCOF1 LARP1 PHKA1 PRRC2C ANKRD17

4.29e-05203108635012549
Pubmed

Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1.

LATS1 LATS2

5.71e-054108228754671
Pubmed

Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.

ARID1B SCN1A

5.71e-054108226637798
Pubmed

Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK.

ANKHD1 ANKRD17

5.71e-054108214557257
Pubmed

RNA-driven cyclin-dependent kinase regulation: when CDK9/cyclin T subunits of P-TEFb meet their ribonucleoprotein partners.

HEXIM1 HEXIM2

5.71e-054108218655042
Pubmed

Inactivation of the Hippo tumor suppressor pathway promotes melanoma.

LATS1 LATS2

5.71e-054108235768444
Pubmed

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

SCN1A SCN9A

5.71e-054108222260870
Pubmed

Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice.

PHKA1 PHKB

5.71e-05410823472241
Pubmed

Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.

LATS1 LATS2

5.71e-054108221041411
Pubmed

Hippo signalling maintains ER expression and ER+ breast cancer growth.

LATS1 LATS2

5.71e-054108233658690
Pubmed

Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.

LATS1 LATS2

5.71e-054108220841485
Pubmed

WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice.

LATS1 LATS2

5.71e-054108232451369
Pubmed

KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases.

LATS1 LATS2

5.71e-054108221233212
Pubmed

The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis.

LATS1 LATS2

5.71e-054108221822051
Pubmed

Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer.

HEXIM1 HEXIM2

5.71e-054108215994294
Pubmed

Phosphorylation of CHO1 by Lats1/2 regulates the centrosomal activation of LIMK1 during cytokinesis.

LATS1 LATS2

5.71e-054108225786116
Pubmed

RASSF1A-Mediated Suppression of Estrogen Receptor Alpha (ERα)-Driven Breast Cancer Cell Growth Depends on the Hippo-Kinases LATS1 and 2.

LATS1 LATS2

5.71e-054108234831091
Pubmed

Binding of Kif23-iso1/CHO1 to 14-3-3 is regulated by sequential phosphorylations at two LATS kinase consensus sites.

LATS1 LATS2

5.71e-054108225658096
Pubmed

Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease.

PHKA1 PHKB

5.71e-05410821872871
Pubmed

Hippo signaling instructs ectopic but not normal organ growth.

LATS1 LATS2

5.71e-054108236395225
Pubmed

Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.

LATS1 LATS2

5.71e-054108215343267
Pubmed

HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.

HEXIM1 HEXIM2

5.71e-054108215713662
Pubmed

Phosphorylase Kinase Deficiency

PHKA1 PHKB

5.71e-054108221634085
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

UBAP2 TCOF1 LATS1 EGR2 SCN1A UNK CAMTA1 SUFU

6.13e-05430108835044719
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

TCOF1 HEXIM1 HEXIM2 PHKA1 PRRC2C MAPKAPK3 MASTL WDFY3

6.33e-05432108823455922
Pubmed

Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.

COPA TCOF1 SEC24A LARP1 ECPAS ANKHD1 TXNL1 ANKRD17

8.28e-05449108831732153
InteractionLRRC31 interactions

COPA LARP1 MED1 ECPAS PHKB MSH6 PRRC2C ANKRD17 TOP3B

1.48e-062051079int:LRRC31
InteractionMVB12B interactions

VPS37A SPPL3 TOP3B MVB12B

3.41e-06201074int:MVB12B
InteractionCNOT2 interactions

UBAP2 SPPL3 LARP1 ANKHD1 PRRC2C ANKRD17 UNK TOP3B

4.90e-061781078int:CNOT2
InteractionPLA2G6 interactions

SERTAD2 PLA2G6 TOP3B CCDC33

7.35e-06241074int:PLA2G6
InteractionNFIC interactions

TET2 ERG SEC24A BIRC2 HMG20A ARID1B LATS2 EGR2

1.64e-052101078int:NFIC
InteractionZNF500 interactions

SPPL3 HEXIM2 TOP3B

1.70e-05101073int:ZNF500
InteractionGAREM2 interactions

GRB2 ECPAS TOP3B

2.33e-05111073int:GAREM2
InteractionANKRD17 interactions

UBAP2 ECPAS ANKHD1 MSH6 PRRC2C ANKRD17 UNK TOP3B

2.78e-052261078int:ANKRD17
InteractionBICRA interactions

ERG SPPL3 ARID1B EGR2 TOP3B

2.85e-05671075int:BICRA
InteractionTBR1 interactions

NCOA2 TET2 HEXIM1 HMG20A ARID1B LATS1

3.10e-051131076int:TBR1
InteractionWWP2 interactions

UBAP2 TCOF1 NELFA GRB2 LARP1 DARS1 HEXIM1 ABRAXAS2 ARID1B LATS1 UBE2J2 EGR2 PRRC2C ANKRD17 PALLD

3.71e-0584010715int:WWP2
InteractionALG13 interactions

NCOA2 C15orf39 ARID1B LATS1 PRRC2C UNK WDFY3

5.51e-051831077int:ALG13
InteractionNAA40 interactions

UBAP2 DSG1 TCOF1 DLGAP5 WDR70 LARP1 DARS1 MED1 ANKHD1 CRACD MSH6 PRRC2C ATF7IP MASTL ANKRD17 PALLD

5.70e-0597810716int:NAA40
InteractionNFIA interactions

NCOA2 ERG ETV3 TERF2IP HMG20A ARID1B EGR2

6.53e-051881077int:NFIA
InteractionQPRT interactions

ANKHD1 ARID1B PRRC2C ANKRD17 SUFU

8.50e-05841075int:QPRT
InteractionPIK3R3 interactions

SLC31A1 SPPL3 SERTAD2 GRB2 DARS1 WDFY3 CCDC33

9.04e-051981077int:PIK3R3
InteractionNCOA6 interactions

NCOA2 ERG MED1 TERF2IP EGR2 TOP3B

1.24e-041451076int:NCOA6
InteractionCPEB1 interactions

UBAP2 LARP1 ANKHD1 PRRC2C ANKRD17 UNK

1.29e-041461076int:CPEB1
InteractionSOX10 interactions

NCOA2 ERG HMG20A ARID1B EGR2

1.31e-04921075int:SOX10
InteractionRGMA interactions

NBEAL1 TERF2IP TOP3B

1.33e-04191073int:RGMA
InteractionZNF263 interactions

ANKHD1 MSH6 ANKRD17 SUFU TOP3B ZNF445

1.44e-041491076int:ZNF263
InteractionZC3H7A interactions

UBAP2 ANKHD1 PRRC2C UCP3 ANKRD17 UNK TOP3B

1.51e-042151077int:ZC3H7A
InteractionEGLN3 interactions

NCOA2 TET2 DENND4A UBAP2 COPA SEC24A DLGAP5 GRB2 C15orf39 BIRC2 ECPAS ANKHD1 NDUFB4 HEXIM1 MSH6 MASTL ANKRD17 SUFU

1.54e-04129610718int:EGLN3
InteractionLY6K interactions

SPPL3 LY6K

1.66e-0441072int:LY6K
InteractionANKLE1 interactions

SPPL3 TOP3B

1.66e-0441072int:ANKLE1
InteractionERG interactions

NCOA2 TET2 ERG C15orf39 HMG20A ARID1B ATF7IP

1.89e-042231077int:ERG
InteractionYWHAZ interactions

HEXA TET2 DENND4A NELFA SEC24A RAP1GAP2 GRB2 LARP1 SPIRE1 ZHX2 HEXIM1 CRACD LATS1 LATS2 UCP3 ANKRD17 UNK WDFY3

1.91e-04131910718int:YWHAZ
InteractionSOX6 interactions

NCOA2 ERG C15orf39 ZHX2 HMG20A PRRC2C

1.92e-041571076int:SOX6
InteractionDUSP5 interactions

SPPL3 ANKHD1 ANKRD17 TOP3B

2.08e-04551074int:DUSP5
InteractionZNF341 interactions

SPPL3 GRB2 TOP3B

2.08e-04221073int:ZNF341
GeneFamilyESCRT-I

VPS37A MVB12B

5.84e-0497421116
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN9A

5.84e-0497421203
GeneFamilyWD repeat domain containing|BEACH domain containing

NBEAL1 WDFY3

5.84e-0497421230
GeneFamilyMyotubularins|Phosphoinositide phosphatases

MTMR8 MTMR7

1.68e-0315742903
GeneFamilyDyneins, axonemal

DNAH10 DNAH2

2.16e-0317742536
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

KIRREL3 LRFN5 SDK1 PALLD

4.30e-03161744593
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

NPR2 DENND4A

4.66e-0325742504
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Stem_cells-neuroepithelial-like_cells|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

NCOA2 NPR2 RAP1GAP2 ZHX2 LRFN5 MYO1F

6.79e-0712710869071cd0953c8bb6746dc9cd13d153e3d6ef40b08
ToppCelldroplet-Heart-4Chambers-21m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPR2 TCOF1 DLGAP5 RAP1GAP2 WDFY3 TOP3B

3.83e-061711086e852d0e8589eecf4a2e5fea039b52a67c5d58dbd
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERG ITGA1 PKHD1L1 PRRC2C ATF7IP CDH11

6.21e-0618610860ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ERG ITGA1 CRACD LRFN5 PALLD CDH11

7.01e-06190108670c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ERG ITGA1 CRACD LRFN5 PALLD CDH11

7.23e-061911086107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ERG ITGA1 CRACD LRFN5 PALLD CDH11

7.23e-061911086bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NCOA2 DENND4A ZHX2 ANKHD1 ARID1B ANKRD17

7.67e-061931086779276e775cb2492e8dd36436295a536084a6415
ToppCellCOVID-19-kidney-Fibroblast-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

ITGA1 CRACD LRFN5 SDK1 PALLD CDH11

8.14e-0619510863d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SERTAD2 RAP1GAP2 SLC12A5 PHKB ALOX15B

3.15e-051491085a85a051e0d82430160967e72fa04b55f43e84513
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SERTAD2 RAP1GAP2 SLC12A5 PHKB ALOX15B

3.26e-0515010857a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell367C-Lymphocytic-ILC-ILC-3|367C / Donor, Lineage, Cell class and subclass (all cells)

ITGA1 ANKHD1 TERF2IP CD96 MVB12B

3.58e-0515310859d64aadbb4bb28469af1d728457b431e21577429
ToppCellCOVID-CD8-memory_CD4|COVID / Condition, Cell_class and T cell subcluster

ZNF793 NPR2 HEXIM1 PRR19 UNK

4.70e-05162108522b2a32217d357146c117e618813d451510a1801
ToppCellhealthy_donor-Myeloid-Monocytic-Developing_Neutrophil|healthy_donor / Disease condition, Lineage, Cell class and subclass

ERG DNAH10 ZNF670 DLGAP5 MMP8

5.91e-051701085cfd7f29805b7c51666b0eaf269c36c96b8765a1a
ToppCellT_cells-GNLY+GZMB+_T_cells|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

ZNF670 RAP1GAP2 LILRB1 MYO1F PALLD

6.08e-05171108504c811817cfec45af5f2891793106cc7ddb0300e
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NBEAL1 ETV3 C15orf39 PALLD ALOX15B

7.15e-051771085d34b086a5931d7f1737a504952d51c47693e91a8
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERG NBEAL1 ITGA1 TTLL7 PRRC2C

7.35e-05178108501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SEMA3G TTLL7 KIRREL3 SLITRK2 SCN1A

8.16e-051821085bfb725fff3d20066d8ac0a6ba2f88498fcbd876e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 TTLL7 CRACD PALLD CDH11

8.37e-051831085667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 PKHD1L1 SLITRK2 SCN9A SDK1

8.59e-0518410852cbed6462fea2622871bb7e49b0df3d984239281
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 CRACD LRFN5 PALLD CDH11

8.59e-051841085c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 PKHD1L1 SLITRK2 SCN9A SDK1

8.59e-051841085ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 PKHD1L1 SLITRK2 SCN9A SDK1

8.59e-0518410852b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND4A COPA SERTAD2 SPIRE1 ZHX2

8.81e-051851085eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

NCOA2 NBEAL1 ITGA1 MED1 CRACD

9.04e-05186108503db813598b67b1e08f759758a1c2023396921fa
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

ITGA1 TTLL7 SDK1 PALLD CDH11

9.27e-051871085464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellCOVID-19-kidney-Fibroblast-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

ITGA1 CRACD LRFN5 SDK1 CDH11

9.27e-05187108576bfe8c42430a230a8bdf299575c444fb7780f24
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ITGA1 TERF2IP MYO1F CD96 MVB12B

9.27e-051871085d17352f769c3c66601b65d060626eecff41b0482
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

ITGA1 CRACD LRFN5 PALLD CDH11

9.27e-051871085bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 CRACD LRFN5 PALLD CDH11

9.74e-05189108571397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 CRACD LRFN5 PALLD CDH11

9.74e-0518910854eea4759520c312bd17a681034d8074e47093d2b
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

ITGA1 LRFN5 SDK1 PALLD CDH11

9.99e-0519010853a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 CRACD LRFN5 PALLD CDH11

1.02e-04191108539092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ITGA1 LRFN5 SDK1 PALLD CDH11

1.02e-0419110856688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 CRACD LRFN5 PALLD CDH11

1.02e-041911085ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 CRACD LRFN5 PALLD CDH11

1.05e-041921085bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 CRACD LRFN5 PALLD CDH11

1.05e-0419210850ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DENND4A TCOF1 ZHX2 ARID1B ATF7IP

1.07e-041931085bbea475d2c4c7b29674ff302529f8f83dd666dcb
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

ERG ITGA1 CRACD PALLD CDH11

1.07e-041931085e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NPR2 ABCF3 C2CD4C HEXIM2 LRFN5

1.07e-041931085e5016959f24370579a8770787e96869f264cf7b3
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

WDR70 SPPL3 ARID1B PRRC2C SDK1

1.07e-041931085e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

ITGA1 LRFN5 SDK1 PALLD CDH11

1.07e-041931085acad568621ed677031797b8c2e34dafea798d681
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 CRACD LRFN5 PALLD CDH11

1.10e-04194108581713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCellControl-Fibroblasts-Intermediate_pathological_FB|Control / group, cell type (main and fine annotations)

ITGA1 CRACD LRFN5 PALLD CDH11

1.10e-04194108503a269f75a481ea54aea8e6444605db8d6df493d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 CRACD LRFN5 PALLD CDH11

1.10e-041941085cf0244a29934e515446ac917d3c30672b460fb04
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ITGA1 TERF2IP ATF7IP CD96 MVB12B

1.10e-041941085b0a7f5ca0c6f4f5764a8b35b5de80d82b828c66c
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ITGA1 LRFN5 SDK1 PALLD CDH11

1.10e-04194108535f132cc38ac133be01834ed0946188aa0757eb4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 CRACD LRFN5 PALLD CDH11

1.10e-041941085ba7f971fb9a19423602da60770f23d9fead4a451
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERG ITGA1 TTLL7 PALLD CDH11

1.10e-041941085ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 CRACD LRFN5 PALLD CDH11

1.10e-041941085627cffe2d448e74fc5df92e74e5b922a73304137
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERG ITGA1 CRACD PALLD CDH11

1.13e-04195108549c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERG ITGA1 CRACD PALLD CDH11

1.13e-041951085dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

NCOA2 WDR70 ZHX2 ARID1B SDK1

1.16e-041961085ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellCOVID-19-Myeloid-Monocytes|COVID-19 / group, cell type (main and fine annotations)

TET2 RAP1GAP2 GRB2 LILRB1 MYO1F

1.16e-04196108504d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERG ITGA1 CRACD PALLD CDH11

1.16e-041961085fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

TET2 RAP1GAP2 GRB2 LILRB1 MYO1F

1.16e-041961085cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ERG ITGA1 CRACD PALLD CDH11

1.16e-041961085802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA1 TTLL7 MTMR7 LRFN5 PALLD

1.16e-0419610859830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCellnucseq-Mesenchymal-Fibroblastic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ITGA1 LRFN5 SDK1 PALLD CDH11

1.16e-0419610857d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TET2 SPIRE1 DARS1 EGR2 PRRC2C

1.18e-0419710855bc11aff92da2a0aca8473f997fe7a99f3cae75d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ERG ITGA1 LRFN5 PALLD CDH11

1.18e-04197108585a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ERG ITGA1 LRFN5 PALLD CDH11

1.18e-041971085e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCellBAL-Mild-cDC_10|Mild / Compartment, Disease Groups and Clusters

DENND4A SERTAD2 ETV3 PHKB CRACD

1.18e-041971085c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCelldistal-Hematologic-Nonclassical_Monocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RAP1GAP2 C15orf39 LILRB1 MAPKAPK3 MYO1F

1.18e-041971085e817c1a8549e403e723b1b6c73cdb04f1179909d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ERG ITGA1 LRFN5 PALLD CDH11

1.18e-0419710859b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

DENND4A NBEAL1 RBP5 LILRB1 MSH6

1.21e-041981085af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

TET2 GRB2 LILRB1 PRRC2C MYO1F

1.21e-04198108561ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

DENND4A NBEAL1 RBP5 LILRB1 MSH6

1.21e-041981085ad39cce004867f083f8da1954e0cf5a263815184
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

DENND4A NBEAL1 RBP5 LILRB1 MSH6

1.21e-04198108562cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ITGA1 LRFN5 SDK1 PALLD CDH11

1.21e-0419810858f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

NCOA2 WDR70 ZHX2 ARID1B WDFY3

1.24e-04199108594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellChildren_(3_yrs)-Immune-monocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TET2 RAP1GAP2 GRB2 LILRB1 MYO1F

1.27e-042001085881ab995c90d75fd987d6e8f1f926a4bfcc4235f
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA1 LRFN5 SDK1 PALLD CDH11

1.27e-042001085cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

DENND4A ERG ITGA1 SEMA3G EGR2

1.27e-0420010855c638c80661017c85f9390f1b398ac7728c8f001
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA1 LRFN5 SDK1 PALLD CDH11

1.27e-04200108534f52003988ce6329d8deeee1ab875fa77e01e9d
DiseaseEarly Infantile Epileptic Encephalopathy 6

SCN1A SCN9A

1.33e-0521082C4551549
DiseaseGlycogen phosphorylase kinase deficiency

PHKA1 PHKB

7.93e-0541082cv:C0268147
Diseaserisk-taking behaviour

TET2 SLC12A5 MSH6 KIRREL3 ARID1B TTBK1 ABHD5 EGR2 LRFN5 SDK1 MVB12B

1.15e-0476410811EFO_0008579
Diseasecentronuclear myopathy (implicated_via_orthology)

MTMR8 MTMR7

2.75e-0471082DOID:14717 (implicated_via_orthology)
Diseasehematocrit

UBAP2 ERG NBEAL1 DNAH2 SERTAD2 HKDC1 SPIRE1 ITGA1 ABRAXAS2 ARID1B EGR2 ANKRD17

3.34e-04101110812EFO_0004348
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN1A SCN9A

3.66e-0481082C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN1A SCN9A

3.66e-0481082C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN1A SCN9A

3.66e-0481082C0338479
DiseaseMyoclonic Encephalopathy

SCN1A SCN9A

3.66e-0481082C0438414
DiseaseEwings sarcoma

ERG EGR2

3.66e-0481082C0553580
DiseaseBenign Infantile Myoclonic Epilepsy

SCN1A SCN9A

3.66e-0481082C0751120
Diseasebenign neoplasm (implicated_via_orthology)

LATS1 LATS2

3.66e-0481082DOID:0060072 (implicated_via_orthology)
DiseaseMyoclonic Absence Epilepsy

SCN1A SCN9A

3.66e-0481082C0393703
DiseaseFEV change measurement, fatty liver disease

UBE2J2 CAMTA1

3.66e-0481082EFO_0005921, MONDO_0004790
Diseasered blood cell density measurement

TET2 DENND4A ERG DNAH10 DNAH2 SERTAD2 ITGA1 HMG20A ARID1B PLA2G6 CAMTA1

3.88e-0488010811EFO_0007978
DiseaseFebrile Convulsions

SLC12A5 SCN1A

4.70e-0491082C0009952
DiseaseMyoclonic Epilepsy

SCN1A SCN9A

4.70e-0491082C0014550
Diseasecentronuclear myopathy X-linked (implicated_via_orthology)

MTMR8 MTMR7

4.70e-0491082DOID:0111225 (implicated_via_orthology)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN9A

4.70e-0491082C3502809
Diseasevein graft stenosis

ARID1B PALLD

4.70e-0491082EFO_0007051
DiseaseEpilepsy, Myoclonic, Infantile

SCN1A SCN9A

5.86e-04101082C0917800
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN9A

5.86e-04101082DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN9A

5.86e-04101082DOID:0080422 (implicated_via_orthology)
DiseaseEpilepsy

SLC12A5 ARID1B SCN1A SCN9A

7.03e-041091084C0014544
Diseasekidney cancer (implicated_via_orthology)

LATS1 LATS2

7.14e-04111082DOID:263 (implicated_via_orthology)
DiseaseMyoclonic Astatic Epilepsy

SCN1A SCN9A

7.14e-04111082C0393702
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN9A

8.55e-04121082DOID:0060170 (implicated_via_orthology)
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN9A

1.01e-03131082C0751122
Diseaseleukemia

ERG BIRC2 MSH6

1.09e-03551083C0023418
Diseasealkaline phosphatase measurement

NCOA2 TET2 SERTAD2 ITGA1 SLC12A5 PHKB KIRREL3 EGR2 ATF7IP ASL PLA2G6

1.25e-03101510811EFO_0004533
Diseasecardiac troponin T measurement

NCOA2 NELFA UBE2J2 EGR2 SDK1

1.29e-032191085EFO_0005043
Diseasereticulocyte count

DENND4A UBAP2 DNAH10 SPPL3 SERTAD2 LARP1 ITGA1 ZHX2 SLC12A5 MAPKAPK3 PLA2G6

1.57e-03104510811EFO_0007986
DiseaseGlycogen storage disease

PHKA1 PHKB

1.74e-03171082cv:C0017919
Diseaselevel of Sphingomyelin (d38:2) in blood serum

MYO1F ANKRD17

2.18e-03191082OBA_2045179
Diseasecalcium measurement

TET2 VPS37A DNAH2 SEMA3G KIRREL3 MTMR7 ARID1B MVB12B

2.20e-036281088EFO_0004838
Diseaseprostate adenocarcinoma (is_implicated_in)

NCOA2 GRB2

2.42e-03201082DOID:2526 (is_implicated_in)
Diseasetriglyceride measurement, body fat percentage

DNAH10 PLA2G6

2.66e-03211082EFO_0004530, EFO_0007800
Diseasecolorectal carcinoma (is_implicated_in)

NCOA2 MSH6

2.92e-03221082DOID:0080199 (is_implicated_in)
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN9A

2.92e-03221082DOID:2030 (implicated_via_orthology)
Diseaseprogranulin measurement

NCOA2 LRFN5

2.92e-03221082EFO_0004625
Diseasetaste liking measurement

TET2 OR10A3 KIRREL3 ARID1B CDH11 MVB12B

3.09e-033881086EFO_0010155
DiseaseEpilepsy, Cryptogenic

SLC12A5 ARID1B SCN1A

3.42e-03821083C0086237
DiseaseAwakening Epilepsy

SLC12A5 ARID1B SCN1A

3.42e-03821083C0751111
DiseaseAura

SLC12A5 ARID1B SCN1A

3.42e-03821083C0236018
DiseaseCharcot-Marie-Tooth disease (implicated_via_orthology)

MTMR8 MTMR7

3.48e-03241082DOID:10595 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
IFTQPFRMKQGSYST

TDRD5

216

Q8NAT2
TSTAYGVKKNMPQSP

COL17A1

301

Q9UMD9
TSPKTRPQNGSMILY

CAMTA1

96

Q9Y6Y1
MPRPQAVGSSNYAST

ABRAXAS2

331

Q15018
RQQGKPYTGFPMLSA

CCDC33

786

Q8N5R6
YGQTSKMSPRVPQQD

ERG

41

P11308
VMPNYPFINIRSSGV

ETV3

121

P41162
SMAKPRQDYSRTPGQ

MASTL

196

Q96GX5
AYSGSYPMAITPTQK

MASTL

686

Q96GX5
FTPKMQQQPTREFSG

ABCF3

316

Q9NUQ8
SSFPKRNSMTPNAPY

ARID1B

1316

Q8NFD5
PLPTTGMQKADVYSF

NPR2

696

P20594
NTAPTNATYPMPTAK

ANKRD17

2021

O75179
MSLPSVPKAQTSYGF

C2CD4C

136

Q8TF44
QRQFMEPGYPKSISG

MMP8

401

P22894
PGRYFLKSSPSTENM

DENND4A

1501

Q7Z401
PKNQYRSFMSQGSPE

NBEAL1

2331

Q6ZS30
PVSAPRNQTFTYMGK

EGR2

81

P11161
YRMIPPTSKTFLVNN

LRFN5

461

Q96NI6
NFVKNATSYPPMFTQ

CES1P1

76

Q9UKY3
VEGPRTPKYMNNITY

LARP1

371

Q6PKG0
NMTYLQPKSGYSPET

OR10A3

256

P58181
NDNTPMFTQPVYRVS

PCDHGA6

236

Q9Y5G7
PFYSNTGQAISPGMK

MAPKAPK3

241

Q16644
PPINSSVFKEYAGSM

LY6K

126

Q17RY6
KQRAPMYNSGLSPAT

NELFA

371

Q9H3P2
GKGSFPAMITPAYQR

NRAP

166

Q86VF7
RGKGSFPAMITPAYQ

NRAP

236

Q86VF7
RGKGSFPAMITPAYQ

NRAP

306

Q86VF7
RQMRPKTFPASNYTV

LATS1

11

O95835
IMQSSSKFNFPSGRP

LATS1

331

O95835
MRPKTFPATTYSGNS

LATS2

1

Q9NRM7
ANTPQDYSGNMKSFP

MTMR7

576

Q9Y216
KGFTMYGVLNPSTVP

MTMR8

476

Q96EF0
NAPKSPLTGYVRFMN

HMG20A

101

Q9NP66
MYLPTKLFQASRPSF

PHKA1

716

P46020
AYSTGSSLMPQKKNP

ASL

276

P04424
KGQPVAPYNTTQFLM

HEXIM1

196

O94992
VKYMTGTTVLPFNPA

ECPAS

576

Q5VYK3
KLSISFPNMTSNGYP

ITGA1

1001

P56199
MSRQSTLYSFFPKSP

MSH6

1

P52701
QTGMFPRNYVTPVNR

GRB2

201

P62993
VYPNFRPTPKNSLMG

NDUFB4

76

O95168
RPSTTVRYVMGNNPA

DSG1

416

Q02413
MGRTKQAPPQYTFIG

MVB12B

166

Q9H7P6
PAMQSSGSFNYARPK

PALLD

721

Q8WX93
RSGTASSVSYPKQMP

FZD8

676

Q9H461
SRMGPYPQRKVITFN

HYOU1

471

Q9Y4L1
QLRSGSKFPVFNMSY

COPA

356

P53621
QTMPRPYTFQVSSGG

CRACD

531

Q6ZU35
PKFPQSVYQMSVSEA

CDH11

266

P55287
KTYQVTPMTPRSANA

DLGAP5

321

Q15398
GLYSPSTNRGPIQMK

ATF7IP

896

Q6VMQ6
KQRVPTGMSFTNIYS

KIRREL3

666

Q8IZU9
QGPYTSMGKDNFVTP

LAS2

171

Q8IYD9
KSQVSIRYNSMPVPG

SLC31A1

96

O15431
ANPRYSPSVFGKAMV

DNAH10

3531

Q8IVF4
YNTVVQRFLPTPTKM

DNAH2

2596

Q9P225
FRMKQVNIVGPSPYS

SDK1

1146

Q7Z5N4
LRPQMASSKNYGSPL

MED1

1421

Q15648
MTSFYNTPPLGKRGT

PHKB

1051

Q93100
TKNVSMFPGNPERFS

SLC12A5

831

Q9H2X9
FTFPELMRKGSYNPV

HEXA

216

P06865
KPQFSAAPMTLLYQS

ALOX15B

306

O15296
MPPNLTGYYRFVSQK

RBP5

1

P82980
FNPVLYPKASQMIVS

RAP1GAP2

236

Q684P5
YMTPGLTPANSQASK

TCOF1

1206

Q13428
GKRHVQMESQFYPTP

HKDC1

101

Q2TB90
QKYQAEFPMGPVTSA

LILRB1

376

Q8NHL6
NPKMSRSVGYSYPSL

SEC24A

281

O95486
MFAKGQPVAPYNTTQ

HEXIM2

131

Q96MH2
SSSLQPYRSQPAFMQ

PRRC2C

2461

Q9Y520
PYRSQPAFMQSSLSQ

PRRC2C

2466

Q9Y520
RFMSANPSKVSYEPI

SCN9A

1866

Q15858
RQSFGPIMVYQTKSP

SLITRK2

321

Q9H156
FYTMPDPRNPKQSNS

DARS1

401

P14868
PNGYPIHSAMKFSQK

PLA2G6

251

O60733
YKSGTPMQSAAKAPY

PI4KAP2

256

A4QPH2
ERFMASNPSKVSYQP

SCN1A

1891

P35498
MSSYQQKQTFTPPPQ

SPRR3

1

Q9UBC9
TPSGETAFKNMTIPY

ABHD5

256

Q8WTS1
MHKTASQRLFPGPSY

BIRC2

1

Q13490
YQSLYMGNEPTPTKS

AKAP3

156

O75969
RMQPRGSFYSMVPNA

ANKHD1

2136

Q8IWZ3
TGPYPRNSKQAMSEG

C15orf39

231

Q6ZRI6
TTPQGSNYALKMNSP

NCOA2

456

Q15596
YTGTFAGQPVRFKMT

TOP3B

41

O95985
VKTRYMNSPPGQYFS

UCP3

241

P55916
QYGPTMFVPPASAKQ

UBAP2

926

Q5T6F2
AFTQNPALMYKPAVS

ZNF793

196

Q6ZN11
KPSNFAMGRLPSTYR

TTBK1

156

Q5TCY1
VFGNAPPNTMTEKFS

WDFY3

61

Q8IZQ1
PQPSNSSMTTRGFNY

CD96

431

P40200
QQGTKEFTFPMPYTS

PRR19

231

A6NJB7
YSSQPVTPSQPFKMD

SERTAD2

286

Q14140
GPANISGRMQKVSYF

SPPL3

301

Q8TCT6
RKTQSFYMSSPGPSE

SPIRE1

731

Q08AE8
SPAYSKTQPKTMFAQ

WDR70

621

Q9NW82
PSIYMITPNGRFKCN

UBE2J2

76

Q8N2K1
VSMYRNVGSPSANIP

SUFU

71

Q9UMX1
GRSFPQKMAYFVSSL

PKHD1L1

246

Q86WI1
TMINSFNKFPYPTQA

ZHX2

276

Q9Y6X8
NYRNMASLVGPFTKP

ZNF445

266

P59923
MTAQPGRPFGSTKDY

SEMA3G

386

Q9NS98
MSFPSSGRQSFYRNP

TPTE2

231

Q6XPS3
TSSVPGMNANALPFY

UNK

491

Q9C0B0
MPGGLPRQAYTQKTT

TET2

611

Q6N021
TPTYNLKYNSPGMTR

TTLL7

861

Q6ZT98
ASIPTSQNGFGYKMP

VPS37A

211

Q8NEZ2
GSSMSFYVRPSPAKR

TERF2IP

26

Q9NYB0
PSVFQMPQSTYTGEK

ZNF670

181

Q9BS34
APAFSSMSNKYPQAV

TXNL1

41

O43396
GSVLISVNPFKQMPY

MYO1F

51

O00160
SVNPFKQMPYFTDRE

MYO1F

56

O00160
SSRASPSQYMGPKRF

NAPEPLD

151

Q6IQ20