Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity	ALG10 ALG10B	8.01e-06	2	57	2	GO:0106073
GeneOntologyMolecularFunction	olfactory receptor activity	OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	2.89e-05	431	57	8	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	CYSLTR2 GPR15 OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1 GPR119	3.43e-05	884	57	11	GO:0004930
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	3.55e-04	10	57	2	GO:0001849
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	CYSLTR2 GPR15 OR2M7 HLA-DPA1 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1 GPR119	3.64e-04	1353	57	12	GO:0004888
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2M7 OR10H4 C4B OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	1.45e-05	524	58	9	GO:0009593
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	2.66e-05	432	58	8	GO:0050911
GeneOntologyBiologicalProcess	sensory perception	OR2M7 MYO9A WFS1 ALG10 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1 ALG10B	3.54e-05	1072	58	12	GO:0007600
GeneOntologyBiologicalProcess	sensory perception of smell	OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	4.48e-05	465	58	8	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	6.03e-05	485	58	8	GO:0050907
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	1.39e-04	547	58	8	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus	OR2M7 OR10H4 C4B OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	1.72e-04	722	58	9	GO:0051606
GeneOntologyBiologicalProcess	auditory receptor cell development	PAFAH1B1 ALG10 ALG10B	1.94e-04	40	58	3	GO:0060117
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	2.12e-04	582	58	8	GO:0050906
GeneOntologyBiologicalProcess	positive regulation of apoptotic cell clearance	C4A C4B	2.15e-04	8	58	2	GO:2000427
GeneOntologyBiologicalProcess	ATF6-mediated unfolded protein response	MBTPS2 WFS1	2.76e-04	9	58	2	GO:0036500
GeneOntologyBiologicalProcess	regulation of apoptotic cell clearance	C4A C4B	3.45e-04	10	58	2	GO:2000425
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	MFSD2A TMEM53 OR2M7 RHBDF1 SLC37A3 MBTPS2 SAMD8 HLA-DPA1 WFS1 ALG10 OR2M5 TMEM39A OR2M3 PIGU ALG10B	2.85e-06	1327	59	15	GO:0042175
GeneOntologyCellularComponent	endoplasmic reticulum membrane	MFSD2A OR2M7 RHBDF1 SLC37A3 MBTPS2 SAMD8 HLA-DPA1 WFS1 ALG10 OR2M5 TMEM39A OR2M3 PIGU ALG10B	1.07e-05	1293	59	14	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	MFSD2A OR2M7 RHBDF1 SLC37A3 MBTPS2 SAMD8 HLA-DPA1 WFS1 ALG10 OR2M5 TMEM39A OR2M3 PIGU ALG10B	1.13e-05	1299	59	14	GO:0098827
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	2.17e-04	8	59	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	2.78e-04	9	59	2	GO:0044217
MousePheno	abnormal renal glomerulus morphology	FRAS1 NF1 MYO9A C4A PKN1 C4B NCKAP1L	4.14e-06	264	36	7	MP:0005325
MousePheno	bleb	FRAS1 ALG10 ALG10B	4.41e-06	13	36	3	MP:0008854
MousePheno	abnormal renal corpuscle morphology	FRAS1 NF1 MYO9A C4A PKN1 C4B NCKAP1L	8.20e-06	293	36	7	MP:0002827
MousePheno	abnormal kidney cortex morphology	FRAS1 NF1 MYO9A C4A PKN1 C4B NCKAP1L	1.58e-05	324	36	7	MP:0000521
MousePheno	cortical renal glomerulopathies	FRAS1 MYO9A C4A PKN1 C4B	4.63e-05	156	36	5	MP:0000523
MousePheno	abnormal nephron morphology	FRAS1 NF1 MYO9A C4A PKN1 C4B NCKAP1L	9.02e-05	426	36	7	MP:0003881
MousePheno	absent distortion product otoacoustic emissions	WFS1 ALG10 ALG10B	1.56e-04	41	36	3	MP:0004737
MousePheno	renal glomerular protein deposits	C4A PKN1 C4B	1.68e-04	42	36	3	MP:0020518
MousePheno	increased anti-nuclear antigen antibody level	BTN2A3P C4A PKN1 C4B	2.09e-04	115	36	4	MP:0004794
MousePheno	increased glucagon secretion	WFS1 CADPS2	2.30e-04	9	36	2	MP:0002710
MousePheno	absent cochlear microphonics	ALG10 ALG10B	2.86e-04	10	36	2	MP:0004413
MousePheno	increased autoantibody level	BTN2A3P C4A PKN1 C4B	3.64e-04	133	36	4	MP:0003725
Domain	MacrogloblnA2_CS	A2M C4A C4B	1.57e-06	8	58	3	IPR019742
Domain	Thiol-ester_cl	A2M C4A C4B	1.57e-06	8	58	3	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	A2M C4A C4B	1.57e-06	8	58	3	IPR019565
Domain	A2M_N	A2M C4A C4B	3.36e-06	10	58	3	PF01835
Domain	A2M_N_2	A2M C4A C4B	3.36e-06	10	58	3	PF07703
Domain	A2M_N	A2M C4A C4B	3.36e-06	10	58	3	IPR002890
Domain	A-macroglobulin_rcpt-bd	A2M C4A C4B	3.36e-06	10	58	3	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	A2M C4A C4B	3.36e-06	10	58	3	PS00477
Domain	A2M_recep	A2M C4A C4B	3.36e-06	10	58	3	PF07677
Domain	A2M_comp	A2M C4A C4B	3.36e-06	10	58	3	PF07678
Domain	A2M	A2M C4A C4B	3.36e-06	10	58	3	PF00207
Domain	A2M_N_2	A2M C4A C4B	3.36e-06	10	58	3	IPR011625
Domain	A2M_comp	A2M C4A C4B	3.36e-06	10	58	3	IPR011626
Domain	Macroglobln_a2	A2M C4A C4B	3.36e-06	10	58	3	IPR001599
Domain	GPCR_Rhodpsn_7TM	CYSLTR2 GPR15 OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1 GPR119	5.71e-06	670	58	11	IPR017452
Domain	7tm_1	CYSLTR2 GPR15 OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1 GPR119	6.31e-06	677	58	11	PF00001
Domain	G_PROTEIN_RECEP_F1_1	CYSLTR2 GPR15 OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1 GPR119	7.05e-06	685	58	11	PS00237
Domain	G_PROTEIN_RECEP_F1_2	CYSLTR2 GPR15 OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1 GPR119	7.65e-06	691	58	11	PS50262
Domain	GPCR_Rhodpsn	CYSLTR2 GPR15 OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1 GPR119	7.76e-06	692	58	11	IPR000276
Domain	Alg10	ALG10 ALG10B	9.48e-06	2	58	2	IPR016900
Domain	CAPS	CADPS CADPS2	9.48e-06	2	58	2	IPR033227
Domain	Miga	MIGA2 MIGA1	9.48e-06	2	58	2	IPR019392
Domain	Miga	MIGA2 MIGA1	9.48e-06	2	58	2	PF10265
Domain	DIE2_ALG10	ALG10 ALG10B	9.48e-06	2	58	2	PF04922
Domain	Terpenoid_cyclase/PrenylTrfase	A2M C4A C4B	2.24e-05	18	58	3	IPR008930
Domain	Olfact_rcpt	OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	2.74e-05	393	58	8	IPR000725
Domain	Anaphylatoxin_comp_syst	C4A C4B	9.42e-05	5	58	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	9.42e-05	5	58	2	IPR001840
Domain	DUF1041	CADPS CADPS2	9.42e-05	5	58	2	SM01145
Domain	ANATO	C4A C4B	1.97e-04	7	58	2	SM00104
Domain	DUF1041	CADPS CADPS2	1.97e-04	7	58	2	PF06292
Domain	Munc13_1	CADPS CADPS2	1.97e-04	7	58	2	IPR014770
Domain	ANAPHYLATOXIN_2	C4A C4B	1.97e-04	7	58	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	1.97e-04	7	58	2	PS01177
Domain	ANATO	C4A C4B	1.97e-04	7	58	2	PF01821
Domain	CAPS_dom	CADPS CADPS2	1.97e-04	7	58	2	IPR010439
Domain	MHD1	CADPS CADPS2	1.97e-04	7	58	2	PS51258
Domain	Anaphylatoxin/fibulin	C4A C4B	1.97e-04	7	58	2	IPR000020
Domain	A2M_N_2	A2M C4A	2.62e-04	8	58	2	SM01359
Domain	-	A2M C4A	2.62e-04	8	58	2	2.60.40.690
Domain	A2M_recep	A2M C4A	2.62e-04	8	58	2	SM01361
Domain	A2M	A2M C4A	2.62e-04	8	58	2	SM01360
Domain	-	A2M C4A	6.13e-04	12	58	2	1.50.10.20
Domain	C345C	C4A C4B	1.25e-03	17	58	2	SM00643
Domain	NTR	C4A C4B	1.57e-03	19	58	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	1.57e-03	19	58	2	IPR018933
Domain	Netrin_domain	C4A C4B	2.30e-03	23	58	2	IPR001134
Domain	NTR	C4A C4B	2.30e-03	23	58	2	PS50189
Domain	TIMP-like_OB-fold	C4A C4B	2.94e-03	26	58	2	IPR008993
Domain	RA	MYO9A RASSF6	4.16e-03	31	58	2	SM00314
Domain	7TM_GPCR_Srsx	GPR15 OR2M3 OR1L3	5.10e-03	112	58	3	SM01381
Domain	RA	MYO9A RASSF6	5.58e-03	36	58	2	PF00788
Domain	RA	MYO9A RASSF6	5.89e-03	37	58	2	PS50200
Domain	RA_dom	MYO9A RASSF6	6.85e-03	40	58	2	IPR000159
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	2.76e-05	389	45	8	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	4.52e-05	417	45	8	M4072
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	2.07e-04	7	45	2	MM14685
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	2.76e-04	8	45	2	M27031
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	2.76e-04	8	45	2	M47872
Pathway	REACTOME_MITOTIC_SPINDLE_CHECKPOINT	ANAPC1 PAFAH1B1 CENPI DYNC1LI2	4.23e-04	111	45	4	M27673
Pathway	REACTOME_MITOTIC_SPINDLE_CHECKPOINT	ANAPC1 PAFAH1B1 CENPI DYNC1LI2	5.16e-04	117	45	4	MM15387
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	5.38e-04	11	45	2	MM1430
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	5.38e-04	11	45	2	M47874
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_ALG6_TO_OST	ALG10 ALG10B	5.38e-04	11	45	2	M47614
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	6.44e-04	12	45	2	MM1368
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	7.60e-04	13	45	2	M4732
Pathway	REACTOME_SENSORY_PERCEPTION	OR2M7 OR10H4 OR2M5 OR2M3 OR5L2 OR1L3 OR52N1 OR52A1	8.06e-04	636	45	8	M41834
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	1.02e-03	15	45	2	M7146
Pathway	REACTOME_RHO_GTPASE_EFFECTORS	PAFAH1B1 CENPI PKN1 DYNC1LI2 NCKAP1L	1.30e-03	257	45	5	MM14755
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	1.31e-03	17	45	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	1.31e-03	17	45	2	MM1369
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	A2M C4A C4B	1.37e-03	69	45	3	M16894
Pathway	REACTOME_CELL_CYCLE_CHECKPOINTS	ORC5 ANAPC1 PAFAH1B1 CENPI DYNC1LI2	1.65e-03	271	45	5	MM15388
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	1.83e-03	20	45	2	M917
Pathway	WP_COMPLEMENT_ACTIVATION	C4A C4B	2.21e-03	22	45	2	M39502
Pathway	REACTOME_CELL_CYCLE_CHECKPOINTS	ORC5 ANAPC1 PAFAH1B1 CENPI DYNC1LI2	2.25e-03	291	45	5	M16647
Pubmed	High-throughput microarray detection of olfactory receptor gene expression in the mouse.	OR2M7 OR2M5 OR2M3	1.85e-08	4	59	3	15377787
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	2.83e-06	2	59	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	2.83e-06	2	59	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	2.83e-06	2	59	2	15998580
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	2.83e-06	2	59	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	2.83e-06	2	59	2	17728371
Pubmed	CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells.	CADPS CADPS2	2.83e-06	2	59	2	18177725
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	2.83e-06	2	59	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	2.83e-06	2	59	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	2.83e-06	2	59	2	3696167
Pubmed	Structure and organization of the C4 genes.	C4A C4B	2.83e-06	2	59	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	2.83e-06	2	59	2	6149581
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	2.83e-06	2	59	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	2.83e-06	2	59	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	2.83e-06	2	59	2	19933335
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	2.83e-06	2	59	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	2.83e-06	2	59	2	3542363
Pubmed	CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.	CADPS CADPS2	2.83e-06	2	59	2	18022372
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	2.83e-06	2	59	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	2.83e-06	2	59	2	8132550
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	2.83e-06	2	59	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	2.83e-06	2	59	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	2.83e-06	2	59	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	2.83e-06	2	59	2	12207352
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	2.83e-06	2	59	2	2395880
Pubmed	CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles.	CADPS CADPS2	2.83e-06	2	59	2	18495893
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	2.83e-06	2	59	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	2.83e-06	2	59	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	2.83e-06	2	59	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	2.83e-06	2	59	2	16908004
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	2.83e-06	2	59	2	30026462
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	2.83e-06	2	59	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	2.83e-06	2	59	2	7365238
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	2.83e-06	2	59	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	2.83e-06	2	59	2	27758680
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	2.83e-06	2	59	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	2.83e-06	2	59	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	2.83e-06	2	59	2	17506029
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	2.83e-06	2	59	2	22387014
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	2.83e-06	2	59	2	17971360
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	2.83e-06	2	59	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	2.83e-06	2	59	2	20506482
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	2.83e-06	2	59	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	2.83e-06	2	59	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	2.83e-06	2	59	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	2.83e-06	2	59	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	2.83e-06	2	59	2	17971229
Pubmed	CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons.	CADPS CADPS2	2.83e-06	2	59	2	28883501
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	2.83e-06	2	59	2	12480675
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	2.83e-06	2	59	2	6881182
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	2.83e-06	2	59	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	2.83e-06	2	59	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	2.83e-06	2	59	2	23918728
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	2.83e-06	2	59	2	3944109
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	2.83e-06	2	59	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	2.83e-06	2	59	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	2.83e-06	2	59	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	2.83e-06	2	59	2	4216347
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	2.83e-06	2	59	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	2.83e-06	2	59	2	21880985
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	2.83e-06	2	59	2	1699796
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	2.83e-06	2	59	2	6978711
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	2.83e-06	2	59	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	2.83e-06	2	59	2	2997024
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	2.83e-06	2	59	2	35898513
Pubmed	CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.	CADPS CADPS2	2.83e-06	2	59	2	25719439
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	2.83e-06	2	59	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	2.83e-06	2	59	2	3008092
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	2.83e-06	2	59	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	2.83e-06	2	59	2	3624865
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	2.83e-06	2	59	2	28873507
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	2.83e-06	2	59	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	2.83e-06	2	59	2	21857912
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	2.83e-06	2	59	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	2.83e-06	2	59	2	2900855
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	2.83e-06	2	59	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	2.83e-06	2	59	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	2.83e-06	2	59	2	4514997
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	2.83e-06	2	59	2	276882
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	2.83e-06	2	59	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	2.83e-06	2	59	2	5919331
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	2.83e-06	2	59	2	6832377
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	2.83e-06	2	59	2	3167981
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	2.83e-06	2	59	2	3794341
Pubmed	Complement and c4 null alleles in severe chronic adult periodontitis.	C4A C4B	2.83e-06	2	59	2	17257223
Pubmed	Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.	C4A C4B	2.83e-06	2	59	2	2272665
Pubmed	Multiple C4/Slp genes distinguished by expression after transfection.	C4A C4B	2.83e-06	2	59	2	3023818
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	2.83e-06	2	59	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	2.83e-06	2	59	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	2.83e-06	2	59	2	2572548
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	2.83e-06	2	59	2	22785613
Pubmed	The complement component C4 of mammals.	C4A C4B	2.83e-06	2	59	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	2.83e-06	2	59	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	2.83e-06	2	59	2	34358307
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	2.83e-06	2	59	2	32691186
Pubmed	Two distinct secretory vesicle-priming steps in adrenal chromaffin cells.	CADPS CADPS2	2.83e-06	2	59	2	20855507
Pubmed	Genetic deficiency in complement component 4b does not alter radiation-induced lung disease in mice.	C4A C4B	2.83e-06	2	59	2	23259761
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	2.83e-06	2	59	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	2.83e-06	2	59	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	2.83e-06	2	59	2	18091514
Cytoband	1q44	OR2M7 OR2M5 OR2M3	3.95e-04	110	59	3	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2M7 OR2M5 OR2M3	6.14e-04	128	59	3	chr1q44
Cytoband	19p13.12	OR10H4 PKN1	1.91e-03	50	59	2	19p13.12
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	A2M C4A C4B	1.12e-06	9	44	3	1234
GeneFamily	Alpha-1,2-glucosyltransferases	ALG10 ALG10B	5.79e-06	2	44	2	448
GeneFamily	Butyrophilins\|V-set domain containing\|C2-set domain containing	BTNL3 BTN2A3P	5.96e-04	15	44	2	458
GeneFamily	Olfactory receptors, family 2	OR2M7 OR2M5 OR2M3	2.61e-03	113	44	3	149
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	3.46e-03	36	44	2	492
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B	3.65e-03	37	44	2	454
GeneFamily	Olfactory receptors, family 52	OR52N1 OR52A1	6.33e-03	49	44	2	165
Disease	Long Qt Syndrome 2	ALG10 ALG10B	9.85e-06	3	54	2	C3150943
Disease	nonsyndromic deafness (implicated_via_orthology)	ALG10 ALG10B	4.91e-05	6	54	2	DOID:0050563 (implicated_via_orthology)
Disease	leptin measurement	GPR15 ALG10 ALG10B	4.47e-04	81	54	3	EFO_0005000
Disease	nephrotic syndrome (biomarker_via_orthology)	A2M KCNJ1	8.84e-04	24	54	2	DOID:1184 (biomarker_via_orthology)
Disease	Complement deficiency disease	C4A C4B	1.67e-03	33	54	2	C0272242

Protein segments in the cluster

Peptide	Gene	Start	Entry
DRSHIYTFPHSAFSV	BTN2A3P	436	Q96KV6
ETFLLFFSFLHVHTP	ARSF	281	P54793
HLVCSFRLYPFTVHT	DCANP1	131	Q8TF63
RLTTEHLYFTFNPHF	BTNL3	381	Q6UXE8
VFVDHHLAPSFYFVA	C4B	531	P0C0L5
HSHVPYTSVFLPVFY	GPR15	26	P49685
SLFLPRTDYSFHKFH	HLA-DPA1	166	P20036
FHKFHYLTFVPSAED	HLA-DPA1	176	P20036
SHEACLHFPQLFYFF	ALG10B	281	Q5I7T1
HTAYLVFSPSKSFVH	A2M	446	P01023
HFYNHETSIFIPAFE	RASSF6	216	Q6ZTQ3
HFVTSLDFHKTAPYV	PAFAH1B1	381	P43034
EELSSHFYTVIPHNF	PARP3	251	Q9Y6F1
FTHIPAIFFVLHLVY	ANAPC1	756	Q9H1A4
PTLLHYSFAFCASHV	CADPS	746	Q9ULU8
HESIEPTHDIFSFYV	FRAS1	1921	Q86XX4
YIVHKTYGFHFTTPA	DYNC1LI2	286	O43237
GIFNHSPTHTFLFFL	OR2M3	16	Q8NG83
GIFNHSPTHTFLFFL	OR2M5	16	A3KFT3
GIFNHSPTHTFLFFL	OR2M7	16	Q8NG81
SFFTHRFGSHISPYI	OR52A1	261	Q9UKL2
SFFAVFHPHFVLTLS	GPR119	156	Q8TDV5
FHPHFVLTLSCVGFF	GPR119	161	Q8TDV5
NHVYSFSVFEHTIFP	NCKAP1L	691	P55160
FISHFYSVSEHVSPV	MIGA2	491	Q7L4E1
AVFHETPLIIYLFHF	PIGU	61	Q9H490
HLTVVVTHYSFASFI	OR10H4	246	Q8NGA5
PHFHGTEPIFFSFYV	MFSD2A	431	Q8NA29
PHTHVFYLTQSFRFG	FBH1	691	Q8NFZ0
PTLLHYSFAFCASHV	CADPS2	711	Q86UW7
HLHYTVSITSFIPRF	MBTPS2	416	O43462
FDYFHLSVISVTVHA	FAM135B	156	Q49AJ0
NVVHHPSFLSYAVSF	CENPI	681	Q92674
YLHFPTFHAEFSADI	CNTNAP5	801	Q8WYK1
VFVDHHLAPSFYFVA	C4A	531	P0C0L4
ISSYIFFCFPHIHTI	OMD	346	Q99983
AFPITFSYFHSLLHV	OR1L3	146	Q8NH93
VLTYVPAFFTFFTHH	OR52N1	251	Q8NH53
FFAHFYAICEHISPV	MIGA1	526	Q8NAN2
FFILAAHEHYSIDVF	SAMD8	336	Q96LT4
HHFSFPSIFIYGHTA	ORC5	26	O43913
DHRPFFTYWLTFVHS	RHBDF1	401	Q96CC6
HIHSDVFSEPRAIFY	PKN1	706	Q16512
VSSRLHTPVYFFLSH	OR5L2	51	Q8NGL0
HTPVYFFLSHLSFVD	OR5L2	56	Q8NGL0
SHEACLHFPQLFYFF	ALG10	281	Q5BKT4
FFLCFLPYHTLRTVH	CYSLTR2	256	Q9NS75
FLHDIEPSIFHDASY	SLC45A4	326	Q5BKX6
QPYLFTRHVHFLNFS	UST	161	Q9Y2C2
FSHHHVVVFLLTFFS	SLC37A3	16	Q8NCC5
HASFDYDHLPALFFV	TMEM232	126	C9JQI7
VPSDVSHARFYFLFH	TMEM39A	401	Q9NV64
VLLAPITALFHTHFY	TMEM53	186	Q6P2H8
LGSSFYSHLPELHIF	ZNF808	156	Q8N4W9
VAAHLPYLFHVVTFL	NF1	2096	P21359
LGSSFYSHLPELHIF	ZNF611	156	Q8N823
ELSHYEFHTIPFIFI	SLC9C2	326	Q5TAH2
VFDHFPEILFIHRTY	ZSWIM1	71	Q9BR11
HLEPYAHFLLSVFFV	WFS1	401	O76024
FFISPLTIYHVIDHN	KCNJ1	261	P48048
YSFQDFVSHFHVLLP	MYO9A	956	B2RTY4
TLHFVHPLTFNYSGV	NECTIN3	321	Q9NQS3