Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhormone binding

CRHR2 IGF1R OXTR GLP1R LRP2

1.33e-04103955GO:0042562
GeneOntologyMolecularFunctionpeptide hormone binding

CRHR2 IGF1R OXTR GLP1R

1.36e-0455954GO:0017046
GeneOntologyMolecularFunctionankyrin binding

FLNC SLC8A1 CLTC

1.72e-0423953GO:0030506
GeneOntologyMolecularFunctionneuropilin binding

ABL1 SEMA3A

2.22e-045952GO:0038191
GeneOntologyMolecularFunctionserine-type endopeptidase activity

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

2.95e-04190956GO:0004252
GeneOntologyMolecularFunctionclathrin light chain binding

CLTCL1 CLTC

4.63e-047952GO:0032051
GeneOntologyMolecularFunctionserine-type peptidase activity

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

4.66e-04207956GO:0008236
GeneOntologyMolecularFunctionmodified amino acid transmembrane transporter activity

SLC7A11 SLC6A8 CTNS

5.13e-0433953GO:0072349
GeneOntologyMolecularFunctionserine hydrolase activity

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

5.29e-04212956GO:0017171
GeneOntologyBiologicalProcesspoly(A)+ mRNA export from nucleus

NXF5 NXF3 NXF2 NXF1

5.39e-0625974GO:0016973
GeneOntologyBiologicalProcessbrain development

ABL1 ABL2 APOD TUBGCP2 PHF8 SLC7A11 SEMA3A IGF1R OXTR FKTN PGAP1 LRP2 PRKDC CTNS HYDIN

1.11e-058599715GO:0007420
GeneOntologyBiologicalProcesshead development

ABL1 ABL2 APOD TUBGCP2 PHF8 SLC7A11 SEMA3A IGF1R OXTR FKTN PGAP1 LRP2 PRKDC CTNS HYDIN

2.45e-059199715GO:0060322
GeneOntologyBiologicalProcessresponse to ATP

ENPP1 DGKQ SLC8A1 P2RX5

3.69e-0540974GO:0033198
GeneOntologyBiologicalProcesscentral nervous system development

ABL1 ABL2 ENPP1 APOD TUBGCP2 PHF8 SLC7A11 STAT3 SEMA3A IGF1R OXTR FKTN PGAP1 LRP2 PRKDC CTNS HYDIN

3.93e-0511979717GO:0007417
GeneOntologyBiologicalProcessmodified amino acid transport

SLC7A11 SLC6A8 LRP2 CTNS

5.40e-0544974GO:0072337
GeneOntologyBiologicalProcessregulation of stem cell differentiation

MTA2 ABL1 KDM4C STAT3 PRKDC

1.05e-0499975GO:2000736
GeneOntologyBiologicalProcessnegative regulation of hydrogen peroxide biosynthetic process

STAT3 CTNS

1.31e-044972GO:0010730
GeneOntologyBiologicalProcessDN4 thymocyte differentiation

ABL1 ABL2

1.31e-044972GO:1904157
GeneOntologyBiologicalProcesspositive regulation of establishment of T cell polarity

ABL1 ABL2

1.31e-044972GO:1903905
GeneOntologyBiologicalProcesstranscytosis

IGF1R CLTC LRP2

1.90e-0424973GO:0045056
GeneOntologyBiologicalProcessneural tube closure

LIAS ABL1 ABL2 IFT57 LRP2

1.95e-04113975GO:0001843
GeneOntologyBiologicalProcesstube closure

LIAS ABL1 ABL2 IFT57 LRP2

2.03e-04114975GO:0060606
GeneOntologyCellularComponentnuclear RNA export factor complex

NXF5 NXF3 NXF2 NXF1

1.45e-087964GO:0042272
DomainTap_RNA_bd

NXF5 NXF3 NXF2 NXF1

6.55e-104964PD043466
DomainTap_RNA-bd

NXF5 NXF3 NXF2 NXF1

6.55e-104964IPR015245
DomainTap-RNA_bind

NXF5 NXF3 NXF2 NXF1

6.55e-104964PF09162
DomainNTF2_DOMAIN

NXF5 NXF3 NXF2 NXF1

8.10e-089964PS50177
DomainNTF2

NXF5 NXF3 NXF2 NXF1

8.10e-089964IPR002075
DomainNXF_fam

NXF5 NXF3 NXF2

1.32e-073963IPR030217
Domain-

NXF5 NXF3 NXF2 NXF1

4.52e-07139643.10.450.50
DomainNTF2-like_dom

NXF5 NXF3 NXF2 NXF1

8.57e-0715964IPR032710
DomainNuclear_transport_factor_2_euk

NXF3 NXF2 NXF1

7.23e-068963IPR018222
DomainNTF2

NXF3 NXF2 NXF1

7.23e-068963PF02136
DomainTRYPSIN_HIS

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

1.51e-05103966IPR018114
DomainTRYPSIN_SER

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

1.78e-05106966PS00135
DomainTRYPSIN_HIS

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

1.87e-05107966PS00134
DomainPeptidase_S1A

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

2.56e-05113966IPR001314
DomainClathrin_H-chain_propeller_rpt

CLTCL1 CLTC

2.61e-052962IPR022365
DomainClathrin-link

CLTCL1 CLTC

2.61e-052962PF09268
Domain-

CLTCL1 CLTC

2.61e-0529622.130.10.110
DomainTAP_C

NXF2 NXF1

2.61e-052962PF03943
DomainTAP_C

NXF2 NXF1

2.61e-052962PS51281
DomainF_actin_bind

ABL1 ABL2

2.61e-052962PF08919
DomainF-actin_binding

ABL1 ABL2

2.61e-052962IPR015015
DomainClathrin_heavy_chain

CLTCL1 CLTC

2.61e-052962IPR016341
DomainTAP_C_dom

NXF2 NXF1

2.61e-052962IPR005637
DomainClathrin_H-chain_propeller_N

CLTCL1 CLTC

2.61e-052962IPR001473
DomainTAP_C

NXF2 NXF1

2.61e-052962SM00804
DomainFABD

ABL1 ABL2

2.61e-052962SM00808
DomainClathrin_H-chain_link/propller

CLTCL1 CLTC

2.61e-052962IPR016025
DomainClathrin_propel

CLTCL1 CLTC

2.61e-052962PF01394
DomainClathrin_H-chain_linker_core

CLTCL1 CLTC

2.61e-052962IPR015348
DomainTRYPSIN_DOM

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

2.82e-05115966PS50240
DomainTryp_SPc

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

3.11e-05117966SM00020
DomainTrypsin_dom

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

3.76e-05121966IPR001254
DomainTrypsin

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

3.76e-05121966PF00089
DomainPeptidase_S1_PA

PRSS1 TMPRSS13 PRSS23 CFB PRSS45P MASP2

4.12e-05123966IPR009003
DomainClathrin_H-chain_linker

CLTCL1 CLTC

7.82e-053962IPR012331
DomainCLH

CLTCL1 CLTC

7.82e-053962SM00299
DomainClathrin

CLTCL1 CLTC

5.40e-047962PF00637
DomainCHCR

CLTCL1 CLTC

5.40e-047962PS50236
DomainClathrin_H-chain/VPS_repeat

CLTCL1 CLTC

7.17e-048962IPR000547
Domain-

GBE1 HPSE2 GBA3

7.64e-04359633.20.20.80
DomainGlyco_hydro_catalytic_dom

GBE1 HPSE2 GBA3

9.74e-0438963IPR013781
DomainTRYPSIN_SER

PRSS1 TMPRSS13 CFB MASP2

1.19e-0390964IPR033116
DomainARM-type_fold

CLTCL1 UBR4 FRYL KIFAP3 HEATR6 CLTC PRKDC

1.83e-03339967IPR016024
DomainNucleotide-bd_a/b_plait

DGKQ NXF5 NXF3 NXF2 PARN NXF1

2.16e-03258966IPR012677
DomainDAGKc

DGKQ AGK

2.29e-0314962SM00046
DomainGlycoside_hydrolase_SF

GBE1 HPSE2 GBA3

2.56e-0353963IPR017853
DomainDiacylglycerol_kinase_cat_dom

DGKQ AGK

2.63e-0315962IPR001206
DomainDAGK

DGKQ AGK

2.63e-0315962PS50146
DomainDAGK_cat

DGKQ AGK

2.63e-0315962PF00781
DomainFN3

FLNC COL12A1 IGF1R PTPRK TNN

2.67e-03185965SM00060
DomainNAD/diacylglycerol_kinase

DGKQ AGK

3.38e-0317962IPR016064
DomainFN3_dom

FLNC COL12A1 IGF1R PTPRK TNN

4.49e-03209965IPR003961
Pubmed

Formation of a Tap/NXF1 homotypic complex is mediated through the amino-terminal domain of Tap and enhances interaction with nucleoporins.

NXF5 NXF3 NXF2 NXF1

2.84e-10597417978099
Pubmed

NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation.

NXF5 NXF3 NXF2 NXF1

7.09e-09997411566096
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

MTA2 COL12A1 ENPP1 SSR2 PRSS23 SLC7A11 DRG1 SEMA3A SLC6A8 IGF1R P2RX5 PTPRK FKTN TMEM245 PGAP1 CCT8 BACE2

3.53e-081201971735696571
Pubmed

TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.

NXF5 NXF3 NXF2 NXF1

5.57e-081497411073998
Pubmed

Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.

ABI1 ABL1 ABL2

8.40e-08497310995551
Pubmed

Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability.

NXF5 NXF3 NXF1

8.40e-08497323675524
Pubmed

Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk.

ABL1 ABL2 IGF1R

2.09e-0759738875975
Pubmed

Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells.

NXF5 NXF2 NXF1

2.09e-07597317548835
Pubmed

Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII.

ABL1 ABL2 IGF1R

2.09e-07597311956190
Pubmed

A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.

EPRS1 PRSS1 FLNC CLTCL1 CLTC CCT8 PRKDC

2.56e-0715397727462432
Pubmed

Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling.

ABL1 ABL2 IGF1R

4.18e-07697312198159
Pubmed

Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP.

EPRS1 CLTCL1 PGAP1 CLTC

1.47e-063097422963397
Pubmed

Inceptor counteracts insulin signalling in β-cells to control glycaemia.

ABL1 SSR2 IGF1R GLP1R

2.47e-063497433505018
Pubmed

Molecular cloning and functional characterization of mouse Nxf family gene products.

NXF5 NXF3 NXF1

2.49e-061097315820316
Pubmed

Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.

ABI1 ABL1 ABL2

3.41e-061197320598684
Pubmed

Nuclear export factor family protein participates in cytoplasmic mRNA trafficking.

NXF5 NXF2 NXF1

3.41e-061197316014633
Pubmed

Integrin-mediated dendrite branch maintenance requires Abelson (Abl) family kinases.

ABL1 ABL2

7.70e-06297215987940
Pubmed

JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3.

STAT3 IGF1R

7.70e-06297215998644
Pubmed

The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.

ABL1 ABL2

7.70e-06297222665498
Pubmed

The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation.

ABL1 ABL2

7.70e-06297212220663
Pubmed

Regulation of Id gene expression by type I insulin-like growth factor: roles of Stat3 and the tyrosine 950 residue of the receptor.

STAT3 IGF1R

7.70e-06297211463827
Pubmed

Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1.

ABI1 ABL1

7.70e-06297221320496
Pubmed

Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes.

ABL1 ABL2

7.70e-06297211279004
Pubmed

Abl tyrosine kinase promotes dorsal ruffles but restrains lamellipodia extension during cell spreading on fibronectin.

ABL1 ABL2

7.70e-06297217686996
Pubmed

Insulin-like growth factor 1 receptor and p38 mitogen-activated protein kinase signals inversely regulate signal transducer and activator of transcription 3 activity to control human dental pulp stem cell quiescence, propagation, and differentiation.

STAT3 IGF1R

7.70e-06297224266654
Pubmed

ABL tyrosine kinases: evolution of function, regulation, and specificity.

ABL1 ABL2

7.70e-06297220841568
Pubmed

Stat3 is involved in control of MASP2 gene expression.

STAT3 MASP2

7.70e-06297217971300
Pubmed

Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region.

ENPP1 PTPRK

7.70e-0629728474452
Pubmed

Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I.

IGF1R LRP2

7.70e-06297216306401
Pubmed

Abl family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus.

ABL1 ABL2

7.70e-06297220181697
Pubmed

Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.

CLTCL1 CLTC

7.70e-0629728733129
Pubmed

c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3.

ABL1 ABL2

7.70e-06297220150913
Pubmed

Global Regulation of Differential Gene Expression by c-Abl/Arg Oncogenic Kinases.

ABL1 ABL2

7.70e-06297228555614
Pubmed

BCR/ABL downregulates DNA-PK(CS)-dependent and upregulates backup non-homologous end joining in leukemic cells.

ABL1 PRKDC

7.70e-06297219697154
Pubmed

CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.

CLTCL1 CLTC

7.70e-06297229097553
Pubmed

Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine.

ABL1 ABL2

7.70e-06297219805386
Pubmed

c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression.

ABL1 ABL2

7.70e-06297221892207
Pubmed

The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.

CLTCL1 CLTC

7.70e-06297220065094
Pubmed

Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1.

ABI1 ABL1

7.70e-06297218328268
Pubmed

Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation.

STAT3 SMYD2

7.70e-06297236270984
Pubmed

Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling.

ABL1 ABL2

7.70e-06297233122628
Pubmed

Functional interaction between DNA-PK and c-Abl in response to DNA damage.

ABL1 PRKDC

7.70e-0629729109492
Pubmed

Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma.

STAT3 PTPRK

7.70e-06297225612622
Pubmed

Abl family nonreceptor tyrosine kinases modulate short-term synaptic plasticity.

ABL1 ABL2

7.70e-06297212626632
Pubmed

Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor.

STAT3 IGF1R

7.70e-06297212061821
Pubmed

The Abl family kinases: mechanisms of regulation and signaling.

ABL1 ABL2

7.70e-06297212374288
Pubmed

Defective T cell development and function in the absence of Abelson kinases.

ABL1 ABL2

7.70e-06297218025176
Pubmed

Identification of potential protein interactors of Lrrk2.

EPRS1 CLTC PRKDC

9.34e-061597317400507
Pubmed

Charting the molecular network of the drug target Bcr-Abl.

ABL1 ABL2 UBR4 DRG1 CLTC CCT8 PRKDC

1.01e-0526697719380743
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

MTA2 EPRS1 GBE1 CHD9 TUBGCP2 DRG1 CLTC NFRKB CCT8 PRKDC UHRF2 NXF1 SORD

1.21e-051103971334189442
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

EPRS1 PIGP KDM4C UBR4 CHD9 STAT3 SMYD2 HEATR6 PTPRK CLTC LRP2 PRKDC BACE2 MAP4K4

1.32e-051285971435914814
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

MTA2 EPRS1 UBR4 STAT3 CLTC CCT8 PRKDC MAP4K4

1.66e-0539997837536630
Pubmed

Abl-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukaemic cell adhesion.

ABI1 ABL1

2.31e-05397222014333
Pubmed

Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.

CLTCL1 CLTC

2.31e-05397219509056
Pubmed

ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.

STAT3 IGF1R

2.31e-05397232029900
Pubmed

Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.

ABL1 ABL2

2.31e-05397212748290
Pubmed

Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.

ABL1 ABL2

2.31e-05397223100514
Pubmed

Histone demethylase PHF8 facilitates the development of chronic myeloid leukaemia by directly targeting BCR::ABL1.

ABL1 PHF8

2.31e-05397237469124
Pubmed

Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment.

ABL1 ABL2

2.31e-05397222738912
Pubmed

ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks.

ABL1 ABL2

2.31e-0539729211900
Pubmed

Abi enhances Abl-mediated CDC2 phosphorylation and inactivation.

ABI1 ABL1

2.31e-05397215591787
Pubmed

The MDA-9/Syntenin/IGF1R/STAT3 Axis Directs Prostate Cancer Invasion.

STAT3 IGF1R

2.31e-05397229572229
Pubmed

Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress.

ABL1 ABL2

2.31e-05397215735735
Pubmed

Protection of Cystinotic Mice by Kidney-Specific Megalin Ablation Supports an Endocytosis-Based Mechanism for Nephropathic Cystinosis Progression.

LRP2 CTNS

2.31e-05397231548351
Pubmed

Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia.

ABL1 STAT3

2.31e-05397225134459
Pubmed

Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response.

ABL1 ABL2

2.31e-05397212569093
Pubmed

Suppressor of cytokine signalling-2 limits IGF1R-mediated regulation of epithelial-mesenchymal transition in lung adenocarcinoma.

STAT3 IGF1R

2.31e-05397229559623
Pubmed

c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading.

ABI1 ABL1

2.31e-05397216899465
Pubmed

Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling.

STAT3 IGF1R

2.31e-05397222194466
Pubmed

Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.

ABI1 ABL1

2.31e-05397215657136
Pubmed

c-ABL tyrosine kinase activity is regulated by association with a novel SH3-domain-binding protein.

ABI1 ABL1

2.31e-0539728943360
Pubmed

Non-receptor tyrosine kinases c-Abl and Arg regulate the activity of C/EBPbeta.

ABL1 ABL2

2.31e-05397219563810
Pubmed

Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.

STAT3 IGF1R

2.31e-05397226364612
Pubmed

Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation.

ABL1 ABL2

2.31e-0539729774693
Pubmed

Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells.

STAT3 AGK

2.31e-05397223676499
Pubmed

ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.

ABL1 ABL2

2.31e-05397225691660
Pubmed

Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.

ABL1 ABL2

2.31e-05397212777400
Pubmed

CRISPR/CAS9-mediated knockout of Abi1 inhibits p185Bcr-Abl-induced leukemogenesis and signal transduction to ERK and PI3K/Akt pathways.

ABI1 ABL1

2.31e-05397232276588
Pubmed

MT1-MMP as a downstream target of BCR-ABL/ABL interactor 1 signaling: polarized distribution and involvement in BCR-ABL-stimulated leukemic cell migration.

ABI1 ABL1

2.31e-05397217943163
Pubmed

Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.

CLTCL1 CLTC

2.31e-05397222891263
Pubmed

Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth.

ABI1 ABL1

2.31e-0539729010225
Pubmed

Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity.

ABL1 ABL2

2.31e-05397222396406
Pubmed

Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets.

STAT3 IGF1R

2.31e-05397222120672
Pubmed

Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases.

ABL1 ABL2

2.31e-05397212950161
Pubmed

The complex roles of STAT3 and STAT5 in maintaining redox balance: Lessons from STAT-mediated xCT expression in cancer cells.

SLC7A11 STAT3

2.31e-05397228202313
Pubmed

Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.

CLTCL1 CLTC

2.31e-05397215133132
Pubmed

Role of the adapter protein Abi1 in actin-associated signaling and smooth muscle contraction.

ABI1 ABL1

2.31e-05397223740246
Pubmed

Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity.

ABI1 ABL2

2.31e-0539727590237
Pubmed

Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases.

ABL1 ABL2

2.31e-05397212893824
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

MTA2 EPRS1 PHF8 STAT3 CLTC NFRKB CCT8 PRKDC MAP4K4

2.38e-0554997938280479
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

MTA2 UBR4 GBE1 CHD9 PHF8 STAT3 CCT8 PARN PRKDC UHRF2 NXF1 SORD

2.59e-051014971232416067
Pubmed

Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA.

EPRS1 FLNC CLTC CCT8

3.38e-056597434645483
Pubmed

Hospicells promote upregulation of the ATP-binding cassette genes by insulin-like growth factor-I via the JAK2/STAT3 signaling pathway in an ovarian cancer cell line.

STAT3 IGF1R

4.60e-05497223857432
Pubmed

Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.

CFB MASP2

4.60e-05497221502512
Pubmed

Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor.

ABL1 IGF1R

4.60e-0549729480911
Pubmed

RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth.

STAT3 IGF1R

4.60e-05497216382134
Pubmed

Nxf3 is expressed in Sertoli cells, but is dispensable for spermatogenesis.

NXF5 NXF3

4.60e-05497221308854
Pubmed

Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion.

ABL1 ABL2

4.60e-05497219414610
Pubmed

IGF1/IGF1R/STAT3 signaling-inducible IFITM2 promotes gastric cancer growth and metastasis.

STAT3 IGF1R

4.60e-05497228223169
Pubmed

Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.

ABL1 ABL2

4.60e-05497214993293
GeneFamilyProteases, serine

PRSS1 TMPRSS13 PRSS23 PRSS45P

4.29e-0563564738
GeneFamilyFibronectin type III domain containing

COL12A1 IGF1R PTPRK TNN

1.52e-03160564555
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRK PTPRR

1.91e-0321562813
GeneFamilyPHD finger proteins|Lysine demethylases

KDM4C PHF8

2.49e-0324562485
GeneFamilySH2 domain containing

ABL1 ABL2 STAT3

3.78e-03101563741
GeneFamilyTudor domain containing

KDM4C UHRF2

5.85e-0337562780
GeneFamilySolute carriers

SLC7A11 SLC5A4 SLC6A8 SLC8A1 SLC12A3

7.44e-03395565752
CoexpressionGSE2706_R848_VS_LPS_8H_STIM_DC_DN

GBE1 PRSS23 CFB MSANTD1 PGAP1 AGK MAP4K4

6.98e-06190977M4713
CoexpressionGRADE_COLON_AND_RECTAL_CANCER_UP

EPRS1 UBR4 CFB DRG1 CCT8 PRKDC GEMIN6 BACE2

1.26e-05290978M16740
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

FLNC COL12A1 ABL2 ENPP1 APOD SLC7A11

4.93e-07134976b959899c89d3a0363a3cd2309155280e0fe5ba88
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

FLNC COL12A1 ABL2 ENPP1 APOD SLC7A11

1.34e-0615997692049a8d8fc9997d8d0d76500c72596a9b2394e0
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FLNC COL12A1 ABL2 ENPP1 APOD SLC7A11

1.67e-06165976570483b43ccb5831feec9337b4664814431d40b1
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

FLNC COL12A1 ABL2 ENPP1 APOD SLC7A11

1.67e-061659762026a9a07f4d314cc05c167e491312b373468e46
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

PRSS1 FLNC COL12A1 PRSS23 CFB PTPRR

2.12e-061729760be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MCHR2 GBE1 SEMA3A PTPRK BACE2 DNAH6

2.67e-06179976065a50952e8703fa07767beb6b73a090bf378ca6
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MCHR2 GBE1 HPSE2 PTPRK BACE2 DNAH6

2.94e-06182976205d9ad1ea4b7adee8054496cdde46c9c401a19a
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 PRSS23 CFB CLTC HYDIN SORD

4.63e-061979765c4cee914baf7cb43e9cb99cc9e3ae823856dc15
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ABCA13 NDST4 GLP1R NXF2

5.48e-06539745fa009c9f30c77de6cece40a47da46241f1de54c
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Egln3_(Cortical_subplate_interneuron)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ABCA13 NDST4 GLP1R NXF2

5.48e-065397452a1f2a041e3ba2b11ed753f2f57b78e68b5cc0c
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Thalamus / BrainAtlas - Mouse McCarroll V32

FLNC COL12A1 ABL2 ENPP1 SLC7A11

2.13e-05153975e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Thalamus / BrainAtlas - Mouse McCarroll V32

FLNC COL12A1 ABL2 ENPP1 SLC7A11

2.13e-05153975b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP|Thalamus / BrainAtlas - Mouse McCarroll V32

FLNC COL12A1 ABL2 ENPP1 SLC7A11

2.13e-051539752513edfae62a44e51d3556675a096723194c966c
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

FLNC ABL2 ENPP1 APOD SLC7A11

2.20e-0515497565dbb60f636562eeba3dafadae9c0c7db2b27476
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP1 CRHR2 SLC6A8 OXTR MASP2

2.81e-0516297522f1abd20f43bc7e7fc46969da9962faf70ae5d2
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP1 CRHR2 SLC6A8 OXTR MASP2

2.81e-05162975966df4558140c3d541999ab553f201ae76a1c401
ToppCellHippocampus-Endothelial-ENDOTHELIAL_TIP|Hippocampus / BrainAtlas - Mouse McCarroll V32

FLNC ABL2 ENPP1 APOD SLC7A11

3.34e-0516897526aa96b2b547d11941cb803995ea3d302ee0518c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L3-5_THEMIS_UBE2F|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 SLC7A11 SMYD2 SEMA3A DNAH6

3.34e-05168975bfa1491e8d433933003778b274710d3a16d973cb
ToppCellNS-critical-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ABCA13 PRSS23 CFB BACE2 SORD

3.44e-05169975aec97583b23112060437b619cb429dc32f29285f
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CLTCL1 IFT57 P2RX5 PTPRK BACE2

3.63e-05171975c3e3ea09c73050372314a89b282e36ba5f339d73
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBCC|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

COL12A1 ENPP1 CRHR2 SEMA3A SORD

3.95e-05174975912a9e892b29d945666fc37c986009c97c668ac8
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FLNC ABL2 ENPP1 APOD SLC7A11

4.28e-05177975599cf7f5b774e197a1b43c98e4b9a8c1a618f38a
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MCHR2 GBE1 SEMA3A PTPRK BACE2

4.89e-05182975cc6f9d606a4f8717dc44928ceec2a257636043fd
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MCHR2 GBE1 PTPRK BACE2 DNAH6

4.89e-0518297531efc06d6b073e8e341648207093e5f33c6f9183
ToppCellremission-B_naive|World / disease stage, cell group and cell class

AGPAT5 ENPP1 P2RX5 PTPRK BACE2

4.89e-05182975cc1dfd2de35aee1a26f7efd78e108b60a3556ec5
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

SLC7A11 SLC6A8 TMEM45B PTPRR BACE2

5.02e-0518397515d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MCHR2 GBE1 PTPRK BACE2 DNAH6

5.02e-0518397501ad18f198195ce341bae01a1c8c253cc4607766
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 ABCA13 SLC8A1 LRP2 HYDIN

5.15e-051849752cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 ABCA13 SLC8A1 LRP2 HYDIN

5.15e-05184975ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 ABCA13 SLC8A1 LRP2 HYDIN

5.15e-051849752b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellControl-Epithelial_cells-Airway_goblet|Control / group, cell type (main and fine annotations)

ABCA13 SLC7A11 TMEM45B PTPRR BACE2

5.15e-05184975d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

EPRS1 FRYL SLC7A11 CLTC PRKDC

5.28e-05185975a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NTHL1 APOD CFB BACE2 SORD

5.42e-0518697555fe25f4d0f2bc0fd4802a0a375169f2c41472fc
ToppCell3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNC PRSS23 APOD SMYD2 SEMA3A

5.42e-0518697530dd4164c101006c8d95922d89652b82dbe4b5ea
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

EPRS1 FRYL SLC7A11 CLTC PRKDC

5.42e-051869758571956890fc9894d766ba294a28e376b4aba428
ToppCell10x5'-blood-Lymphocytic_B-Naive_B_cells|blood / Manually curated celltypes from each tissue

AGPAT5 IFT57 P2RX5 PTPRK BACE2

5.70e-051889752b3560b28f9df6f4d4a3e0a4acfa6c7d964ad0fe
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT57 ABCA13 OXTR DNAH6 HYDIN

5.85e-05189975b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCelldroplet-Bladder|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMPRSS13 SLC7A11 TMEM45B PTPRR BACE2

5.99e-05190975170484f7a6f0a0d0792bbe1bb04abad060b7188e
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MCHR2 SLC8A1 PTPRK PTPRR DNAH6

5.99e-0519097549e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 PRSS23 APOD DNAH6 SORD

5.99e-051909752fdc024d3d673a0134b74b4c5a63afe924995730
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

AGPAT5 IFT57 P2RX5 PTPRK BACE2

6.15e-05191975a831e30f37aff329d83fac9bdb84f783075d5df6
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNC PRSS23 APOD SMYD2 SEMA3A

6.15e-05191975361b123c8289015206d5e706ab2c615d9a724179
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT57 ABCA13 OXTR DNAH6 HYDIN

6.15e-05191975683e5c7e6173644f01e67c98ab7b75d7cb9cce99
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNC PRSS23 APOD SMYD2 SEMA3A

6.15e-05191975011dc22c488369734749e839d65d52fe46b6a1a4
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

AGPAT5 IFT57 P2RX5 PTPRK BACE2

6.15e-051919752453064c39b359088d43d52792bf829f83442c82
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC AGPAT5 APOD SEMA3A BACE2

6.30e-051929752ec132a1740e865e7cc0f82ffd4772d43f7ac086
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC AGPAT5 APOD SEMA3A BACE2

6.30e-051929753792c53b5d4b759573e1c7bb89ef9b654c9cbfcd
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC AGPAT5 APOD SEMA3A BACE2

6.30e-0519297564022a47dccd7966777f6741d1c68e298f37ca9d
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC AGPAT5 APOD SEMA3A BACE2

6.30e-05192975f67a88bd039944d3d7a5a4a9f2e053985075155c
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AGPAT5 IFT57 P2RX5 PTPRK BACE2

6.46e-05193975cf4ba50aa4a00d1ba22fc7626d49a4104377d5d9
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

EPRS1 FRYL PTPRK CLTC PRKDC

6.46e-05193975abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellEC-Sinusoidal_ECs|EC / Lineage and Cell class

SSR2 CLTC BACE2 MAP4K4 SORD

6.46e-051939751291b1d3494dcb4b9309f8bff63fb662e7eca0c8
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT57 ABCA13 APOD DNAH6 HYDIN

6.61e-051949753cd90d01ed5a5ce65aad8284dab2537ec16e3d7c
ToppCellNS-critical-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PRSS23 CFB SEMA3A PTPRK SORD

6.61e-051949752172d951896265243d14996eacce5aab5e14e26e
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT57 ABCA13 OXTR DNAH6 HYDIN

6.78e-05195975649fd2336e963f6a150d182a53ad5dd838ca80b1
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT57 ABCA13 APOD DNAH6 HYDIN

6.78e-05195975db4270c135c392ed443670981656e3cd5b95939d
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT57 ABCA13 OXTR DNAH6 HYDIN

6.78e-05195975129ad5f4253ecb1a8477cc38773e6e91ea9570b0
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT57 ABCA13 OXTR DNAH6 HYDIN

6.78e-051959753e70ee987d66d450062d5df3d7c733ccc7344470
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT57 ABCA13 APOD DNAH6 HYDIN

6.78e-051959756365e3893e38231090ec2dbef010dec71dea3d07
ToppCelldistal-Endothelial-Lymphatic-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLNC PRSS23 APOD SEMA3A BACE2

6.78e-05195975f45c1349932ee7eb419cced8a4fdedae3610953f
ToppCellcritical-Epithelial-Secretory|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PRSS23 CFB PTPRK BACE2 SORD

6.94e-051969757da687eb983a54c28ee990424cc52e01caf5f4aa
ToppCellNS-moderate-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ABCA13 PRSS23 CFB PTPRK SORD

6.94e-0519697547930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCellNS-critical-d_07-13-Epithelial-Ciliated-diff|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

IFT57 ABCA13 APOD DNAH6 HYDIN

7.11e-0519797532484fb5dde0a4525dd8028dde01ca5a4e51e4b6
ToppCellproximal-3-Epithelial-Goblet|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ABCA13 PRSS23 CFB BACE2 SORD

7.28e-051989753477202c4f702d8f75231b13d4b5216f56d981d7
ToppCellproximal-Epithelial-Goblet|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ABCA13 PRSS23 CFB BACE2 SORD

7.28e-05198975e7e1c430486a81280abc4a7e7f5bc3713dd20737
ToppCellmoderate-Epithelial-Secretory|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ABCA13 PRSS23 CFB BACE2 SORD

7.28e-051989757d96d7105a849c7280ce87bd76ce130ac47384fd
ToppCellmedial-Endothelial-Lymphatic-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLNC PRSS23 APOD SEMA3A BACE2

7.28e-0519897541983d405215b974044e2e9e6c212b134336a6fe
ToppCellmedial-2-Endothelial-Lymphatic|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLNC PRSS23 APOD SEMA3A BACE2

7.28e-05198975e4274584512a72270087a1ab104fab449a2f83bc
ToppCellproximal-Epithelial-Goblet-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ABCA13 PRSS23 CFB BACE2 SORD

7.28e-05198975da7b40eb00bb5e454e1cfcd1219dc0d84712592a
ToppCellmedial-Endothelial-Lymphatic|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLNC PRSS23 APOD SEMA3A BACE2

7.28e-051989751760fede363544bc0fa2e22fe36aff522abd2525
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 PRSS23 CFB BACE2 SORD

7.46e-051999758bf8d7cd774479f065bbbbcb5a4bd1aa91aa0d85
ToppCellproximal-Epithelial-Mucous-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PRSS1 CFB PRSS45P BACE2 SORD

7.46e-05199975baac580484124b7c36717b607adcf2cb446e631d
ToppCellproximal-Epithelial-Mucous|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PRSS1 CFB PRSS45P BACE2 SORD

7.46e-0519997515ba36fa6ad73d0e959e42f18d7acbc14e310dc9
ToppCellproximal-3-Epithelial-Mucous|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PRSS1 CFB PRSS45P BACE2 SORD

7.46e-051999753018378860de084662be0cc46fce421db3bb9ec9
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 PRSS23 CFB BACE2 SORD

7.46e-051999750c060ef64341659f4b1247d0264ac12e53a7e12e
ToppCellTCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

EPRS1 ABI1 ABL2 ZNF354A SMYD2

7.64e-052009751fa8422fd820d21e285a7e7c4c6fbd8b7277d2af
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA13 PRSS23 CFB BACE2 SORD

7.64e-05200975b68d212159b9d04866ba02ff55c35be247805eec
ToppCellBiopsy_Control_(H.)-Endothelial-Lymphatic_Endothelial_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

FLNC PRSS23 APOD SEMA3A BACE2

7.64e-052009758cf218887ab030b7625610cb65b595170a17ebec
ToppCellsevere-B_naive|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

AGPAT5 IFT57 P2RX5 PTPRK BACE2

7.64e-05200975306df1f498ac2188eaf9f2a8d002bb73bdb9642d
ToppCellmild-B_naive|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

AGPAT5 IFT57 P2RX5 PTPRK BACE2

7.64e-05200975d0467cab6a42bf780aa49046bf3231ca161dc144
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

FLNC ABL2 ENPP1 SLC7A11

1.82e-04129974856255fbfc7f95642000cfd7704141b2388f7c5c
ToppCellGlobus_pallidus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

COL12A1 ABL2 ENPP1 SLC7A11

1.99e-04132974560e836764ed7806fb18282dfebe434d30112a9a
ToppCellURO-Lymphocyte-T_NK-CD8_Naive|URO / Disease, Lineage and Cell Type

GPLD1 SSR2 APOD SLC7A11

2.10e-04134974142b7db0c2b686c8f2704ff7bcd9b44dfcb07403
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chodl|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NDST4 OXTR TMEM45B BACE2

2.29e-041379745cb84392e4483f50e09fb7395e2ec98f3eb6ecf3
ToppCellfacs-Lung-Endomucin-24m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP1 P2RX5 MRPS23 GEMIN6

2.62e-041429740a87c0d74e281da5dc4f59e09a5e99c62b1ea801
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Chodl|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NDST4 OXTR TMEM45B BACE2

2.77e-04144974b622b605f7ec6083ec06c8ea0fd171e07c52f3de
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA13 NDST4 HPSE2 HYDIN

2.84e-0414597496712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ABL2 FRYL SLC8A1 NFRKB

3.23e-04150974744050a1b665c6989f37141348af3df7579a73c9
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CACUL1 C3orf33 FRRS1 HYDIN

3.75e-04156974abea3c183d32062b009a79a2bdf861021989c7ef
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 ZNF354A PRSS23 MASP2

3.94e-04158974f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 ZNF354A PRSS23 MASP2

3.94e-041589748c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

COL12A1 ABL2 APOD SLC7A11

4.03e-04159974cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ABL2 ENPP1 APOD SLC7A11

4.03e-0415997434c90711c5857cf6ada7b3acff99f1d48c7caf29
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 SEMA3A LRP2 HYDIN

4.13e-04160974c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPLD1 GBE1 SERPINA10 SORD

4.13e-04160974c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 SEMA3A LRP2 HYDIN

4.13e-0416097425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellClub_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

ABCA13 CFB BACE2 SORD

4.23e-04161974bd08a23b415617f6e8748ed2668d578a860ecf91
ToppCellBac-SEP-Lymphocyte-B-B_intermediate|Bac-SEP / Disease, Lineage and Cell Type

IFT57 APOD P2RX5 BACE2

4.23e-04161974bcd122af09cbb99d1816200d9c367af8b7f36873
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCA13 NDST4 HPSE2 HYDIN

4.32e-04162974bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tregs|GI_large-bowel / Manually curated celltypes from each tissue

CLTCL1 STAT3 NFRKB DNAH6

4.32e-041629749a5e65c45f73a6a685b8362aa2e6aea77181caa3
DiseaseFanconi syndrome (implicated_via_orthology)

LRP2 CTNS

5.87e-054932DOID:1062 (implicated_via_orthology)
DiseaseLung diseases

CRHR2 STAT3 IGF1R PRKDC

1.10e-0478934C0024115
Diseasediabetic neuropathy (implicated_via_orthology)

IGF1R SORD

8.72e-0414932DOID:9743 (implicated_via_orthology)
Diseasequinate measurement

KDM4C CFB

1.00e-0315932EFO_0021167
Diseaseneutrophil collagenase measurement

ABCA13 CFB

1.15e-0316932EFO_0008248
DiseaseT-Cell Lymphoma

KDM4C STAT3

1.15e-0316932C0079772
Diseasemelanoma

ABL1 KDM4C UBR4 PRSS23 PTPRK

1.15e-03248935C0025202
Diseaseposterior cingulate cortex volume measurement

KDM4C NDST4

1.30e-0317932EFO_0010324
DiseaseCongenital hernia of foramen of Morgagni

STAT3 IGF1R

1.62e-0319932C0265699
DiseaseCongenital hernia of foramen of Bochdalek

STAT3 IGF1R

1.62e-0319932C0265700
DiseaseUsual Interstitial Pneumonia

STAT3 PARN

1.62e-0319932C4721509
DiseaseHamman-Rich Disease

STAT3 PARN

1.62e-0319932C4721508
DiseaseColorectal Carcinoma

PRSS1 FLNC CACUL1 ABCA13 NTHL1 LRP2 UHRF2 GABRA6

1.70e-03702938C0009402
DiseaseFamilial Idiopathic Pulmonary Fibrosis

STAT3 PARN

1.80e-0320932C4721952
DiseaseCongenital diaphragmatic hernia

STAT3 IGF1R

1.98e-0321932C0235833
DiseaseIdiopathic Pulmonary Fibrosis

STAT3 PARN

1.98e-0321932C1800706
Diseaseage at menarche

KDM4C MCHR2 NDST4 MSANTD1 IGF1R PTPRK TMEM245

2.76e-03594937EFO_0004703

Protein segments in the cluster

PeptideGeneStartEntry
DSWIALKYPGIAIYV

TMEM184C

96

Q9NVA4
KYLGRWYEIEKIPTT

APOD

41

P05090
PSLYKGDIWYTPIKE

BACE2

256

Q9Y5Z0
DAGVKVSKYWYLGPL

AGK

216

Q53H12
VSKYWYLGPLKIKAA

AGK

221

Q53H12
EVYVGVWKKYSLTVA

ABL2

301

P42684
LTVQGYPKDLLVYAW

CEACAM16

336

Q2WEN9
IYPGWLKVGVAYVSV

DGKQ

401

P52824
VWTFLKPILHGKILY

ABCA13

3306

Q86UQ4
AWAPKNYIEKVVAIY

ABI1

441

Q8IZP0
YWEYGRIGNFIVKKP

SORD

51

Q00796
VITIEDYKSTYWPKL

CACUL1

126

Q86Y37
IYWKKYGGLKTPTQL

MTA2

396

O94776
KLIYQTLSWKYPKGI

PARN

211

O95453
LVTYATYPKIWVKVS

CFB

311

P00751
ITVPFGIKYNEKWLL

NXF3

116

Q9H4D5
DWPYYLAIDGILAKV

MSANTD1

121

Q6ZTZ1
LKSSVEVYAWAPKPY

MAP4K4

1041

O95819
WDYLKLVRIYTKPKG

DRG1

286

Q9Y295
PCVKYDIGRKLWIYL

NFRKB

636

Q6P4R8
VVPWGIVKYLYEDEG

GLP1R

281

P43220
LKPWTQYAVYVKAVT

IGF1R

571

P08069
KITIPYGRKYDKAWL

NXF1

121

Q9UBU9
RKWFKVTIPYGIKYD

NXF5

11

Q9H1B4
VTIPYGIKYDKAWLM

NXF5

16

Q9H1B4
LKKYIEAIQWIYGLA

DCSTAMP

141

Q9H295
IIKIIGKYVQSPYWK

FRYL

2226

O94915
LVYWGKAIIIYPLCE

NPRL3

316

Q12980
YTVKEKGDYILIVKW

FLNC

2696

Q14315
FPIIVAWAIGKLYYE

CRHR2

236

Q13324
IKSIEKKVLYGYWSA

HEATR6

431

Q6AI08
RKYWKNLTFVAPIYG

KDM4C

121

Q9H3R0
EYITPEKFKYWEKVG

LIAS

321

O43766
PYFEVLEKWIYRGII

TUBGCP2

386

Q9BSJ2
YTWKKGPLYSVEVPE

GABRA6

186

Q16445
YKGEPIWVTAKYQGL

ENPP1

301

P22413
WDPKDIGLSVVYYTV

LRP2

4091

P98164
VYPVHIQLYAAWKKV

NDST4

426

Q9H3R1
GPKAYITWITLAVYI

OXTR

196

P30559
DYWLSLLYKRLIGPK

HPSE2

441

Q8WWQ2
CVLYWPEKRGIYGKV

PTPRR

501

Q15256
LPVWVYSKVIKFKDG

MCHR2

166

Q969V1
DKDTGEPVIYYLVKW

CHD9

786

Q3L8U1
YCKEGKIPWDALIYI

DNAH6

3731

Q9C0G6
GEILYRISPWAKYVV

GBE1

151

Q04446
SETGVKWVYYLKGIT

HYDIN

5106

Q4G0P3
IAYKVLEVFPKGRWV

C17orf99

31

Q6UX52
LKYIGFTWKRPIYPV

IFT57

156

Q9NWB7
WKPAPGKVVNYRVVY

COL12A1

1016

Q99715
IYVVPWGVCKLLKYI

GBA3

346

Q9H227
VVEKYKIYWVKIPGP

FRRS1

146

Q6ZNA5
VYEGVWKKYSLTVAV

ABL1

256

P00519
TVLVKGLKYDSKIYW

C3orf33

181

Q6P1S2
LEYIEANYGKTWKIP

FKTN

416

O75072
YGVYTKVINYIPWIE

MASP2

666

O00187
LWVPYIKEQFLLKYP

CTNS

181

O60931
YILLSADKYEIKIWP

FBXW2

291

Q9UKT8
KKGPLEWQDYIYKEV

GEMIN6

6

Q8WXD5
KYWAVALPVYLLIAI

PIGP

76

P57054
LDWELVLKEYKLVPY

KIFAP3

536

Q92845
NLVEVGRVKCYKYWP

PTPRK

986

Q15262
LAYLVVWVFLIKKGY

P2RX5

41

Q93086
TRNWFKVTIPYGIKY

NXF2

121

Q9GZY0
KVTIPYGIKYDKAWL

NXF2

126

Q9GZY0
VRYGKAKAPIQDIWY

MRPS23

51

Q9Y3D9
IYYEKEPLTIVKLWK

TSEN2

316

Q8NCE0
FYWIIEALGIRKPYI

EPRS1

406

P07814
IYPVGFWRSKVKYIK

NTHL1

176

P78549
ITPLKYAQICYWIKG

PRSS23

361

O95084
ILGWIFVPIYIKSGV

SLC5A4

111

Q9NY91
PFVIIIKFLLGYKWF

PGAP1

641

Q75T13
LDGIIYYLKPDWSKL

SLC6A8

286

P48029
GTVLKVVSIPKETWY

SEMA3A

456

Q14563
WKVDFPYQDKLVGYI

CHAC2

11

Q8WUX2
IVLYAKKVGYTPDWI

CLTC

501

Q00610
IVLYAKKVGYTPDWI

CLTCL1

501

P53675
VTYAWQLLKKELGLY

CNBD2

6

Q96M20
GIYKVVKYWPEISSS

UHRF2

586

Q96PU4
PGVYTRITKYTKWIK

PRSS45P

216

Q7RTY3
IIGLCWSVKYPLKYF

TMEM45B

16

Q96B21
VPAYYLFIIWDKKPR

SLC7A11

461

Q9UPY5
IGIPLLLWYSSKRKY

SSR2

161

P43308
PGVYTKVTEVLPWIY

TMPRSS13

541

Q9BYE2
LKPGEAYKVYVWAER

TNN

501

Q9UQP3
LVKKYILALWNEGYI

STAT3

571

P40763
YLAEVFGPLWIVKVY

SERINC4

361

A6NH21
RWYVPVKDLLGIYEK

GPLD1

181

P80108
LYVIYKKPEVNWGSS

SLC12A3

601

P55017
TGKWKVPTYKDYVDL

PRKDC

516

P78527
ILVDYILFKGKWLTP

SERPINA10

231

Q9UK55
YYKPVKWVISLTPLS

TMEM245

676

Q9H330
VWYHVLKGEKIFYLI

PHF8

291

Q9UPP1
VPWDLKLEKPYIYEG

ZNF354A

116

O60765
PGVYTKVYNYVKWIK

PRSS1

226

P07477
RYVLKEGLKWLPLYG

AGPAT5

116

Q9NUQ2
WEGALQYGQKIIKPY

SMYD2

356

Q9NRG4
WKVYLAARGVLPYVG

UBR4

4196

Q5T4S7
GILDTYLGKYWAIKL

CCT8

496

P50990
GITYFYKEEWPLLIV

ZRANB3

71

Q5FWF4
GSYYCKKGVILPIWE

SLC8A1

51

P32418