Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alcohol transmembrane transporter activity	ABCA4 SLC44A2	1.77e-04	8	51	2	GO:0015665
HumanPheno	Mild malformation of cortical development	SIN3B SIN3A	1.18e-05	2	18	2	HP:0032059
Domain	HDAC_interact	SIN3B SIN3A	7.60e-06	2	52	2	SM00761
Domain	Sin3_corepress	SIN3B SIN3A	7.60e-06	2	52	2	PF08295
Domain	Sin3_C	SIN3B SIN3A	7.60e-06	2	52	2	IPR031693
Domain	Sin3a_C	SIN3B SIN3A	7.60e-06	2	52	2	PF16879
Domain	HDAC_interact_dom	SIN3B SIN3A	7.60e-06	2	52	2	IPR013194
Domain	PAH	SIN3B SIN3A	2.28e-05	3	52	2	IPR003822
Domain	-	SIN3B SIN3A	2.28e-05	3	52	2	1.20.1160.11
Domain	PAH	SIN3B SIN3A	2.28e-05	3	52	2	PS51477
Domain	PAH	SIN3B SIN3A	2.28e-05	3	52	2	PF02671
Domain	FERM-adjacent	PTPN4 EPB41L4A	5.82e-04	13	52	2	IPR014847
Domain	FA	PTPN4 EPB41L4A	5.82e-04	13	52	2	SM01195
Domain	FA	PTPN4 EPB41L4A	5.82e-04	13	52	2	PF08736
Domain	Ez/rad/moesin-like	PTPN4 EPB41L4A	1.54e-03	21	52	2	IPR000798
Domain	TUDOR	TDRD3 KDM4B	1.85e-03	23	52	2	PS50304
Domain	FERM_CS	PTPN4 EPB41L4A	2.02e-03	24	52	2	IPR019747
Domain	FERM_C	PTPN4 EPB41L4A	2.37e-03	26	52	2	PF09380
Domain	TUDOR	TDRD3 KDM4B	2.55e-03	27	52	2	SM00333
Domain	FERM_C	PTPN4 EPB41L4A	2.55e-03	27	52	2	SM01196
Domain	FERM_PH-like_C	PTPN4 EPB41L4A	2.55e-03	27	52	2	IPR018980
Domain	Tudor	TDRD3 KDM4B	3.15e-03	30	52	2	IPR002999
Domain	JMJC	TYW5 KDM4B	3.57e-03	32	52	2	PS51184
Domain	JmjC_dom	TYW5 KDM4B	3.57e-03	32	52	2	IPR003347
Domain	JmjC	TYW5 KDM4B	3.80e-03	33	52	2	SM00558
Domain	FERM_N	PTPN4 EPB41L4A	3.80e-03	33	52	2	PF09379
Domain	FERM_N	PTPN4 EPB41L4A	3.80e-03	33	52	2	IPR018979
Domain	FERM_M	PTPN4 EPB41L4A	7.28e-03	46	52	2	PF00373
Domain	-	PTPN4 EPB41L4A	8.22e-03	49	52	2	1.20.80.10
Domain	FERM_central	PTPN4 EPB41L4A	8.22e-03	49	52	2	IPR019748
Domain	FERM_domain	PTPN4 EPB41L4A	8.22e-03	49	52	2	IPR000299
Pubmed	The mammalian Sin3 proteins are required for muscle development and sarcomere specification.	SIN3B SIN3A	2.37e-06	2	54	2	20956564
Pubmed	Differential Complex Formation via Paralogs in the Human Sin3 Protein Interaction Network.	SIN3B SIN3A	2.37e-06	2	54	2	32467258
Pubmed	SIN3A and SIN3B differentially regulate breast cancer metastasis.	SIN3B SIN3A	2.37e-06	2	54	2	27780928
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF711 SIN3B ESS2 SENP6 SIN3A ZMYM3 KDM4B BRWD1	4.27e-06	608	54	8	36089195
Pubmed	A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.	SIN3B SIN3A	7.09e-06	3	54	2	9139820
Pubmed	Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer cells.	SIN3B SIN3A	7.09e-06	3	54	2	20547842
Pubmed	The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien.	SIN3B SIN3A	7.09e-06	3	54	2	15173382
Pubmed	The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.	SIN3B SIN3A	7.09e-06	3	54	2	22101514
Pubmed	Sin3 interacts with Foxk1 and regulates myogenic progenitors.	SIN3B SIN3A	7.09e-06	3	54	2	22476904
Pubmed	Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression.	SIN3B SIN3A	1.42e-05	4	54	2	9139821
Pubmed	Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes.	SIN3B SIN3A	1.42e-05	4	54	2	10570134
Pubmed	Role of EphA4 and EphrinB3 in local neuronal circuits that control walking.	SIN3B SIN3A	1.42e-05	4	54	2	12649481
Pubmed	Survival motor neuron (SMN) protein interacts with transcription corepressor mSin3A.	SIN3B SIN3A	1.42e-05	4	54	2	14749338
Pubmed	Mnt transcriptional repressor is functionally regulated during cell cycle progression.	SIN3B SIN3A	1.42e-05	4	54	2	16103876
Pubmed	Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology.	SIN3B SIN3A	1.42e-05	4	54	2	22203677
Pubmed	Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential.	SIN3B SIN3A	1.42e-05	4	54	2	15467743
Pubmed	Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein.	SIN3B SIN3A	2.36e-05	5	54	2	9627120
Pubmed	Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.	SIN3B SIN3A	2.36e-05	5	54	2	16166625
Pubmed	Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription.	SIN3B SIN3A	2.36e-05	5	54	2	15489224
Pubmed	Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.	SIN3B SIN3A	2.36e-05	5	54	2	7889570
Pubmed	Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation.	SIN3B SIN3A	2.36e-05	5	54	2	18451802
Pubmed	Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death.	SIN3B SIN3A	3.54e-05	6	54	2	22398430
Pubmed	An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B.	SIN3B SIN3A	3.54e-05	6	54	2	12398767
Pubmed	Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling.	SIN3B SIN3A	3.54e-05	6	54	2	29056338
Pubmed	Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1.	SIN3B SIN3A	3.54e-05	6	54	2	11302704
Pubmed	The Mad1-Sin3B interaction involves a novel helical fold.	SIN3B SIN3A	3.54e-05	6	54	2	11101889
Pubmed	Histone deacetylase 1 can repress transcription by binding to Sp1.	SIN3B SIN3A	3.54e-05	6	54	2	10409740
Pubmed	Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.	SIN3B SIN3A	3.54e-05	6	54	2	11909966
Pubmed	Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.	SIN3B SIN3A ZMYM3	4.79e-05	45	54	3	21258344
Pubmed	Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.	SIN3B SIN3A	4.94e-05	7	54	2	10357820
Pubmed	Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors.	SIN3B SIN3A	4.94e-05	7	54	2	22716292
Pubmed	microRNA-205-5p is a modulator of insulin sensitivity that inhibits FOXO function.	SIN3B SIN3A	6.59e-05	8	54	2	30174230
Pubmed	Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.	SIN3B SIN3A	6.59e-05	8	54	2	8617250
Pubmed	RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest.	SIN3B SIN3A	8.46e-05	9	54	2	11283269
Pubmed	A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.	HECW1 FOXP1	8.46e-05	9	54	2	24121790
Pubmed	SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.	SIN3B SIN3A	8.46e-05	9	54	2	9702189
Pubmed	Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.	SIN3B SIN3A	1.29e-04	11	54	2	14581478
Pubmed	Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.	SIN3B SIN3A	1.83e-04	13	54	2	16469706
Pubmed	A molecular dissection of the repression circuitry of Ikaros.	SIN3B SIN3A	2.13e-04	14	54	2	12015313
Pubmed	The histone deacetylase 9 gene encodes multiple protein isoforms.	SIN3B SIN3A	2.13e-04	14	54	2	12590135
Pubmed	Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA.	SIN3B SIN3A	2.13e-04	14	54	2	20585571
Pubmed	Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.	HECW1 OTUB1	2.80e-04	16	54	2	25723849
Pubmed	Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1.	SIN3B SIN3A	2.80e-04	16	54	2	11102443
Pubmed	Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.	SIN3B SIN3A	2.80e-04	16	54	2	8649810
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF711 TUT4 ARSB TYW5 FOXP1 SIN3A ZMYM3 BRWD1	3.08e-04	1116	54	8	31753913
Pubmed	Ikaros SUMOylation: switching out of repression.	SIN3B SIN3A	3.17e-04	17	54	2	15767674
Pubmed	Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.	SIN3B SIN3A	3.17e-04	17	54	2	32245798
Pubmed	Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.	SIN3B SIN3A	3.56e-04	18	54	2	8521822
Pubmed	mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.	SIN3B SIN3A	3.56e-04	18	54	2	14559996
Pubmed	Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.	SIN3B SIN3A	3.56e-04	18	54	2	10444591
Pubmed	Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.	EPB41L4A F8	3.56e-04	18	54	2	21810271
Pubmed	A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.	SIN3A ZMYM3	3.56e-04	18	54	2	12493763
Pubmed	Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.	SIN3B SIN3A	3.98e-04	19	54	2	22984288
Pubmed	Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.	SIN3B SIN3A	3.98e-04	19	54	2	28554894
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PTPN4 TUT4 KCNQ5 TMEM98 SUPT6H TMEM63B FOXP1 MTARC1 KDM4B	4.40e-04	1489	54	9	28611215
Pubmed	Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.	SIN3B SIN3A	4.88e-04	21	54	2	12670868
Pubmed	Sin3a regulates epithelial progenitor cell fate during lung development.	SIN3B SIN3A	4.88e-04	21	54	2	28619823
Pubmed	SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.	SIN3B SIN3A	5.86e-04	23	54	2	9651585
Pubmed	Transcriptome analysis in blastocyst hatching by cDNA microarray.	SIN3B SIN3A	6.94e-04	25	54	2	15919778
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	ALKAL1 TMEM98 PDGFD MPZL1 CDCP1	7.35e-04	460	54	5	20562862
Pubmed	Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.	SENP6 MTARC1	8.72e-04	28	54	2	22118674
Pubmed	Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.	ZMYM3 BRWD1	9.35e-04	29	54	2	21834987
Pubmed	Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.	SIN3B SIN3A	1.00e-03	30	54	2	16449650
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	SIN3B GALNT8 SIN3A CXXC1 ZMYM3	1.02e-03	495	54	5	27705803
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	SIN3B ESS2 SIN3A	1.20e-03	134	54	3	25452129
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	OTUB1 SENP6 ASTN1 BRWD1	1.31e-03	306	54	4	18973680
Pubmed	Genome-wide association study of selenium concentrations.	ARSB PDGFD	1.36e-03	35	54	2	25343990
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	SIN3B SIN3A	1.45e-04	9	37	2	1306
GeneFamily	Histone deacetylases, class I\|EMSY complex\|NuRD complex\|SIN3 histone deacetylase complex	SIN3B SIN3A	2.66e-04	12	37	2	1243
GeneFamily	Tudor domain containing	TDRD3 KDM4B	2.59e-03	37	37	2	780
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	PTPN4 EPB41L4A	4.69e-03	50	37	2	1293
CoexpressionAtlas	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4	ZNF711 COX6B2 PTPN4 YPEL4 TUT4 ABCA4 ESS2 ST3GAL5 HPS1 TMEM63B FSCN2 NHS ASTN1 KDM4B BRWD1	7.86e-07	1370	53	15	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ALKAL1 HECW1 PDGFD NHS MTARC1	3.15e-06	187	54	5	387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ALKAL1 HECW1 PDGFD NHS MTARC1	3.32e-06	189	54	5	0abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PTPN4 TUT4 SLC44A2 FOXP1 SIN3A	3.87e-06	195	54	5	ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
Disease	esophageal adenocarcinoma	HECW1 FOXP1	4.40e-04	18	51	2	EFO_0000478
Disease	osteoarthritis	USP50 HECW1 SLC44A2 SENP6	5.91e-04	222	51	4	MONDO_0005178
Disease	Mental Retardation, X-Linked	ZNF711 ZMYM3	1.15e-03	29	51	2	C1136249
Disease	eyelid sagging measurement	ARSB KCNQ5	1.41e-03	32	51	2	EFO_0009360
Disease	retinitis pigmentosa (is_implicated_in)	ABCA4 FSCN2	2.30e-03	41	51	2	DOID:10584 (is_implicated_in)
Disease	pulse pressure measurement	USP50 ZNF438 KCNQ5 ALKAL1 SUPT6H OTUB1 FOXP1 KDM4B	2.51e-03	1392	51	8	EFO_0005763

Protein segments in the cluster

Peptide	Gene	Start	Entry
LSRFAYNGKRCPSSY	NT5C3B	46	Q969T7
KDPIYSYDRRTTSFC	ABCA4	356	P78363
RYCQRKSYSLQVPSD	CDCP1	421	Q9H5V8
TRECSTPAYYKRCAR	ALKAL1	101	Q6UXT8
STLTERPCYNRRASK	ANKRD40	351	Q6AI12
LRRSSLKYLGCRYSE	ASTN1	1251	O14525
SKNRYRDISPYDATR	PTPN4	681	P29074
YDPLRYSVKTSRRVC	OR5M11	126	Q96RB7
DAASNLLYRYDPRCK	KLHL36	361	Q8N4N3
SYRQCDPSERKLYGK	MTARC1	296	Q5VT66
RTRRGKSTQPCEYYF	COX6B2	46	Q6YFQ2
SRRRCKEPLRYSYNP	HECW1	31	Q76N89
YTSSQSCRRNVKYRR	KCNQ5	96	Q9NR82
DAKRYSCTPRNYSVN	PDGFD	266	Q9GZP0
RRRYSDKYNVPISSA	FOXP1	436	Q9H334
GEYRRLANSEKYCTP	KDM4B	96	O94953
TKSDPRCLTRYYSSF	F8	541	P00451
RRTASVRADTYCRLY	HCN3	501	Q9P1Z3
YRRKNSKRDYTGCST	MPZL1	191	O95297
RRRAEDYYRCKITPS	NPIPA2	211	E9PIF3
YIRKTRPDGNCFYRA	OTUB1	81	Q96FW1
ASKYTDRALRASYTP	ESS2	406	Q96DF8
RQCQLRARESYKYFP	CXXC1	206	Q9P0U4
TRDYRCLRKTYPSQL	GALNT8	166	Q9NY28
NSNPKDYCYSARIRS	TMEM63B	16	Q5T3F8
GKEARACPYYRSRLA	DDX11L8	346	A8MPP1
SQSRQRTCRRKYPNY	BRWD1	791	Q9NSI6
YRKECLPTRRGFDTY	ARSB	151	P15848
LRLDPSARTYCYKQE	KLHDC9	166	Q8NEP7
CPDRYLTYLNARSSR	SLC44A2	116	Q8IWA5
RYYSKNRPTEAVRCY	HPS1	651	Q92902
SHSPRSYRQYRRSQC	EPB41L4A	591	Q9HCS5
SRRYCLKSCDSRYLR	FSCN2	181	O14926
KCDRPYSRYDRTKDT	TDRD3	376	Q9H7E2
SSSRYSVRCRLYNTP	NHS	1611	Q6T4R5
KSRESYVLCYDPRTR	ENDOG	76	Q14249
CKRLGSSYRALPKSY	SIN3A	551	Q96ST3
YASCKRIGSSYRALP	SIN3B	391	O75182
SEYTYVKLRSDCSRP	ST3GAL5	31	Q9UNP4
CYRTEPYRRLQDAQS	ADGRD2	356	Q7Z7M1
SCRYKDLRTAYRSPN	SUPT6H	1131	Q7KZ85
DCSRSRSPYKARDRS	SRRM5	436	B3KS81
SDPRYKRNICSVKYS	SENP6	846	Q9GZR1
YSRRRSYEKGSTQRC	USP50	156	Q70EL3
LSRYEVCRRSAFPKA	nan	106	A6NLC8
KTFRSYLPRCHRTYS	YPEL4	16	Q96NS1
ANVYPAECRGRRSTY	POLR1B	96	Q9H9Y6
YTRRYREASPLSSNK	ZNF711	451	Q9Y462
RLEKRSPEYTNCRYL	TUT4	291	Q5TAX3
NRRPYSCRICRKSYV	ZNF438	531	Q7Z4V0
FLTLRYSSRRNPYCR	TMEM33	191	P57088
YSSRRNPYCRTLFNE	TMEM33	196	P57088
SPGARSQYVCRLYRS	WWC3	911	Q9ULE0
RSLSDPCYYNKVDRT	ZMYM3	551	Q14202
AKYPLFSKARRYECS	TYW5	206	A2RUC4
YCRPRDLLQRYDSKP	TMEM98	31	Q9Y2Y6