Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbeta-adrenergic receptor kinase activity

GRK2 GRK3

1.89e-054362GO:0047696
GeneOntologyMolecularFunctionneuroligin family protein binding

NRXN3 NRXN1

3.15e-055362GO:0097109
GeneOntologyMolecularFunctionG protein-coupled receptor kinase activity

GRK2 GRK3

6.60e-057362GO:0004703
GeneOntologyBiologicalProcesspostsynaptic density assembly

NRXN3 CSMD2 NRXN1

2.58e-0534353GO:0097107
GeneOntologyBiologicalProcesspostsynaptic specialization assembly

NRXN3 CSMD2 NRXN1

5.65e-0544353GO:0098698
GeneOntologyBiologicalProcessexcitatory synapse assembly

NRXN3 CSMD2 NRXN1

6.46e-0546353GO:1904861
GeneOntologyBiologicalProcesspostsynaptic density organization

NRXN3 CSMD2 NRXN1

1.30e-0458353GO:0097106
GeneOntologyBiologicalProcessiodide transport

ANO1 TG

1.52e-0411352GO:0015705
GeneOntologyBiologicalProcesspostsynaptic specialization organization

NRXN3 CSMD2 NRXN1

2.36e-0471353GO:0099084
GeneOntologyBiologicalProcessneuron cell-cell adhesion

NRXN3 NRXN1

3.31e-0416352GO:0007158
MousePhenoincreased chromosomal stability

ZSCAN5A ZSCAN5C

4.22e-056242MP:0010095
DomainSyndecan

NRXN3 NRXN1

6.72e-057342PF01034
DomainGPCR_kinase

GRK2 GRK3

6.72e-057342IPR000239
DomainSyndecan/Neurexin_dom

NRXN3 NRXN1

6.72e-057342IPR027789
DomainNeurexin-like

NRXN3 NRXN1

2.89e-0414342IPR003585
Domain4.1m

NRXN3 NRXN1

2.89e-0414342SM00294
Domain-

NRXN3 NRXN1 ADGRD1

6.80e-04953432.60.120.200
DomainEGF_3

NRXN3 NRXN1 VWDE SORL1

8.42e-04235344PS50026
DomainEGF

NRXN3 NRXN1 VWDE SORL1

8.42e-04235344SM00181
DomainEGF-like_dom

NRXN3 NRXN1 VWDE SORL1

1.04e-03249344IPR000742
DomainEGF-like_CS

NRXN3 NRXN1 VWDE SORL1

1.24e-03261344IPR013032
DomainEGF_2

NRXN3 NRXN1 VWDE SORL1

1.31e-03265344PS01186
DomainRGS

GRK2 GRK3

1.84e-0335342PF00615
DomainRGS

GRK2 GRK3

1.84e-0335342SM00315
DomainRGS

GRK2 GRK3

1.95e-0336342PS50132
DomainLAM_G_DOMAIN

NRXN3 NRXN1

2.17e-0338342PS50025
DomainRGS

GRK2 GRK3

2.29e-0339342IPR016137
DomainKeratin_B2_2

KRTAP10-11 KRTAP10-3

2.29e-0339342PF13885
DomainLaminin_G_2

NRXN3 NRXN1

2.40e-0340342PF02210
DomainKeratin_B2

KRTAP10-11 KRTAP10-3

2.40e-0340342PF01500
DomainLamG

NRXN3 NRXN1

2.90e-0344342SM00282
Domain6-blade_b-propeller_TolB-like

WSB1 SORL1

3.17e-0346342IPR011042
Domain-

REXO1 WRN

3.30e-03473423.30.420.10
DomainCUB

CSMD1 CSMD2

3.59e-0349342PF00431
DomainCUB

CSMD1 CSMD2

3.73e-0350342SM00042
DomainSushi

CSMD1 CSMD2

4.03e-0352342PF00084
Domain-

CSMD1 CSMD2

4.03e-03523422.60.120.290
DomainCUB

CSMD1 CSMD2

4.18e-0353342PS01180
DomainCCP

CSMD1 CSMD2

4.34e-0354342SM00032
DomainSUSHI

CSMD1 CSMD2

4.66e-0356342PS50923
DomainSCAN

ZSCAN5A ZSCAN5C

4.66e-0356342SM00431
DomainAGC-kinase_C

GRK2 GRK3

4.66e-0356342IPR000961
DomainAGC_KINASE_CTER

GRK2 GRK3

4.66e-0356342PS51285
DomainS_TK_X

GRK2 GRK3

4.66e-0356342SM00133
DomainSushi_SCR_CCP_dom

CSMD1 CSMD2

4.82e-0357342IPR000436
DomainCUB_dom

CSMD1 CSMD2

4.82e-0357342IPR000859
DomainSCAN_BOX

ZSCAN5A ZSCAN5C

4.99e-0358342PS50804
DomainSCAN

ZSCAN5A ZSCAN5C

4.99e-0358342PF02023
DomainLaminin_G

NRXN3 NRXN1

4.99e-0358342IPR001791
DomainKAP

KRTAP10-11 KRTAP10-3

4.99e-0358342IPR002494
DomainSCAN_dom

ZSCAN5A ZSCAN5C

4.99e-0358342IPR003309
DomainRetrov_capsid_C

ZSCAN5A ZSCAN5C

5.16e-0359342IPR008916
DomainRNaseH-like_dom

REXO1 WRN

6.99e-0369342IPR012337
DomainConA-like_dom

NRXN3 NRXN1 ADGRD1

7.28e-03219343IPR013320
DomainG-protein_beta_WD-40_rep

WSB1 TBL1XR1

1.04e-0285342IPR020472
Pubmed

Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study.

NRXN3 NRXN1

1.04e-06236219658047
Pubmed

Cloning of GRK2 cDNA from S49 murine lymphoma cells.

GRK2 GRK3

1.04e-0623628638670
Pubmed

A genetic association study of CSMD1 and CSMD2 with cognitive function.

CSMD1 CSMD2

1.04e-06236227890662
Pubmed

Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.

NRXN3 NRXN1

1.04e-06236237543682
Pubmed

Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.

GRK2 GRK3

1.04e-06236210198406
Pubmed

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.

GRK2 GRK3

1.04e-06236233060647
Pubmed

Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action.

NRXN3 NRXN1

1.04e-0623629430716
Pubmed

The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.

CSMD1 CSMD2

1.04e-06236221439553
Pubmed

Loss of CSMD1 or 2 may contribute to the poor prognosis of colorectal cancer patients.

CSMD1 CSMD2

1.04e-06236224408017
Pubmed

G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.

GRK2 GRK3

1.04e-06236211762794
Pubmed

G protein--coupled receptor kinases.

GRK2 GRK3

1.04e-0623628035170
Pubmed

Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.

GRK2 GRK3

3.12e-06336210754297
Pubmed

Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.

NRXN3 NRXN1

3.12e-06336234133920
Pubmed

Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.

NRXN3 NRXN1

3.12e-06336238891114
Pubmed

Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.

NRXN3 NRXN1

3.12e-06336212036300
Pubmed

β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.

NRXN3 NRXN1

3.12e-06336226213384
Pubmed

Neurexin gene family variants as risk factors for autism spectrum disorder.

NRXN3 NRXN1

3.12e-06336229045040
Pubmed

Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.

NRXN3 NRXN1

3.12e-06336231005376
Pubmed

Identification of two new members of the CSMD gene family.

CSMD1 CSMD2

3.12e-06336212906867
Pubmed

Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.

NRXN3 NRXN1

3.12e-06336238571813
Pubmed

Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons.

NRXN3 NRXN1

3.12e-06336235173587
Pubmed

Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.

GRK2 GRK3

3.12e-06336210085131
Pubmed

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.

GRK2 GRK3

3.12e-0633627761854
Pubmed

The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.

GRK2 GRK3

3.12e-06336231604529
Pubmed

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.

NRXN3 NRXN1

3.12e-06336230858964
Pubmed

GRK2 Fine-Tunes Circadian Clock Speed and Entrainment via Transcriptional and Post-translational Control of PERIOD Proteins.

GRK2 PER2

3.12e-06336226279567
Pubmed

Neurexins are differentially expressed in the embryonic nervous system of mice.

NRXN3 NRXN1

3.12e-0633627722633
Pubmed

Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.

NRXN3 NRXN1

3.12e-06336226446217
Pubmed

Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.

NRXN3 NRXN1

3.12e-06336228013231
Pubmed

Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk.

GRK2 GRK3

3.12e-06336212130708
Pubmed

Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

NRXN3 NRXN1

3.12e-06336211944992
Pubmed

alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.

NRXN3 NRXN1

3.12e-06336216406382
Pubmed

Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.

NRXN3 NRXN1

3.12e-06336233058888
Pubmed

Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.

NRXN3 NRXN1

3.12e-06336217035546
Pubmed

Neurexins: three genes and 1001 products.

NRXN3 NRXN1

3.12e-0633629448462
Pubmed

Deletion of α-neurexin II results in autism-related behaviors in mice.

NRXN3 NRXN1

3.12e-06336225423136
Pubmed

Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.

NRXN3 NRXN1

3.12e-06336231812984
Pubmed

Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.

NRXN3 NRXN1

6.24e-06436214983056
Pubmed

Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.

GRK2 GRK3

6.24e-0643628917529
Pubmed

Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.

ZSCAN5A ZSCAN5C

6.24e-06436231155506
Pubmed

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.

NRXN3 NRXN1

6.24e-0643628786425
Pubmed

ZSCAN5B and primate-specific paralogs bind RNA polymerase III genes and extra-TFIIIC (ETC) sites to modulate mitotic progression.

ZSCAN5A ZSCAN5C

6.24e-06436227732952
Pubmed

Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.

NRXN3 NRXN1

6.24e-06436217347997
Pubmed

Neurexins cluster Ca2+ channels within the presynaptic active zone.

NRXN3 NRXN1

6.24e-06436232134527
Pubmed

Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.

NRXN3 NRXN1

6.24e-06436232706374
Pubmed

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.

GRK2 GRK3

6.24e-06436221784156
Pubmed

Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.

GRK2 GRK3

6.24e-0643628662816
Pubmed

Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.

GRK2 GRK3

6.24e-06436223734232
Pubmed

Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins.

NRXN3 NRXN1

6.24e-06436235385735
Pubmed

Neurexins regulate presynaptic GABAB-receptors at central synapses.

NRXN3 NRXN1

6.24e-06436233888718
Pubmed

Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins.

NRXN3 NRXN1

1.04e-05536228472659
Pubmed

Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.

NRXN3 NRXN1

1.04e-05536236709330
Pubmed

Neuroligins and neurexins link synaptic function to cognitive disease.

NRXN3 NRXN1

1.04e-05536218923512
Pubmed

Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.

GRK2 GRK3

1.04e-05536210338466
Pubmed

Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum.

NRXN3 NRXN1

1.04e-05536220537373
Pubmed

Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner.

NRXN3 NRXN1

1.04e-05536236205393
Pubmed

Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration.

NRXN3 NRXN1

1.04e-0553629223334
Pubmed

Structures, alternative splicing, and neurexin binding of multiple neuroligins.

NRXN3 NRXN1

1.56e-0563628576240
Pubmed

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

GRK2 GRK3

1.56e-0563629826657
Pubmed

Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.

NRXN3 NRXN1

1.56e-05636230683685
Pubmed

Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.

GRK2 GRK3

1.56e-05636236451830
Pubmed

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.

NRXN3 NRXN1

1.56e-05636212827191
Pubmed

Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn.

NRXN3 NRXN1

1.56e-05636219816407
Pubmed

Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.

GRK2 GRK3

1.56e-05636220074556
Pubmed

Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.

GRK2 GRK3

2.18e-0573628672451
Pubmed

Glycosylation of Cblns attenuates their receptor binding.

NRXN3 NRXN1

2.18e-05736229782851
Pubmed

Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.

GRK2 GRK3

2.18e-05736211517230
Pubmed

Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.

NRXN3 NRXN1

2.18e-0573629856994
Pubmed

GluD1 is a signal transduction device disguised as an ionotropic receptor.

NRXN3 NRXN1

2.91e-05836234135511
Pubmed

Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.

NRXN3 NRXN1

2.91e-05836230871858
Pubmed

Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.

NRXN3 NRXN1

2.91e-05836237591863
Pubmed

Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells.

GRK2 GRK3

3.73e-05936234873237
Pubmed

PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.

NRXN3 NRXN1

3.73e-0593629707552
Pubmed

Molecular self-avoidance in synaptic neurexin complexes.

NRXN3 NRXN1

3.73e-05936234919427
Pubmed

Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.

PCSK2 NRXN3 NRXN1

4.66e-056736316987237
Pubmed

Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936.

SORL1 WRN

4.66e-051036219077115
Pubmed

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family.

GRK2 GRK3

4.66e-05103621869533
Pubmed

SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.

NRXN3 NRXN1

5.70e-051136232973045
Pubmed

The contribution of rare and common variants in 30 genes to risk nicotine dependence.

NRXN3 NRXN1

9.41e-051436225450229
Pubmed

1.3 A X-ray structure of an antibody Fv fragment used for induced membrane-protein crystallization.

IGHV3-53 IGHV3-66

1.08e-041536212657787
Pubmed

A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3.

KRTAP10-11 KRTAP10-3

1.24e-041636215028290
Pubmed

A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.

NRXN1 TG

1.40e-041736222832960
Pubmed

MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.

NRXN3 NRXN1

1.40e-041736227779093
Pubmed

Cbln1 regulates axon growth and guidance in multiple neural regions.

NRXN3 NRXN1

2.38e-042236236395107
Pubmed

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response.

IGHV3-53 IGHV3-66

2.38e-04223622499654
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

MACF1 NRXN3 NRXN1

3.18e-0412836330995482
Pubmed

Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development.

NRXN3 NRXN1

3.87e-042836238324473
Pubmed

A genome-wide association study of behavioral disinhibition.

CSMD1 NRXN1

4.45e-043036223942779
Pubmed

NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance.

ZSCAN5A ZSCAN5C

5.07e-043236238060382
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

ANO1 MACF1 ADGRD1

5.26e-0415236334299191
Pubmed

Joint influence of small-effect genetic variants on human longevity.

NRXN1 ADGRD1

5.72e-043436220834067
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

MACF1 GRK3 CSMD1 CDK14 TBL1XR1 ADGRD1 NEMF

7.28e-04148936728611215
Cytoband19q13.43

ZSCAN5A ZSCAN5C

2.14e-038736219q13.43
CytobandEnsembl 112 genes in cytogenetic band chr14q21

KLHL28 NEMF

2.66e-0397362chr14q21
Cytoband21q22.3

KRTAP10-11 KRTAP10-3

4.57e-0312836221q22.3
GeneFamilyExonucleases

REXO1 WRN

2.36e-0416262544
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CSMD1 CSMD2

3.02e-03572621179
GeneFamilyKeratin associated proteins

KRTAP10-11 KRTAP10-3

1.07e-02109262619
CoexpressionMIKKELSEN_MCV6_LCP_WITH_H3K27ME3

KRTAP10-11 TG KRTAP10-3

7.90e-0630343MM835
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANO1 PCSK2 NRXN3 CSMD1 ADGRD1

2.49e-0717036599dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANO1 PCSK2 NRXN3 CSMD1 ADGRD1

2.49e-071703653a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANO1 PCSK2 NRXN3 CSMD1 ADGRD1

2.49e-07170365cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK2 CSMD1 CDK14 NRXN1 SORL1

4.91e-071953652e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK2 NRXN3 CSMD1 CDK14 NRXN1

5.04e-07196365676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellTracheal-10x3prime_v2-Stromal-Schwann|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

WSB1 PCSK2 NRXN3 CDK14 NRXN1

5.43e-071993658dc65662c3ca1db2ba0091332f0658abc0afc5de
ToppCellTracheal-10x3prime_v2-Stromal-Schwann-Schwann_nonmyelinating|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

WSB1 PCSK2 NRXN3 CDK14 NRXN1

5.43e-07199365a92718a3f1153b8d2196fd343ed5bc0ebc98cad7
ToppCellControl-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MACF1 GRK2 GRK3 SORL1

7.32e-061553640a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCellSevere-B_naive-1|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MACF1 GRK2 GRK3 SORL1

8.10e-061593642881b054bbeb479221ee3c38bbd9b0815b123579
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

NRXN3 CSMD1 CSMD2 NRXN1

8.10e-061593645335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 CSMD2 NRXN1

8.51e-061613647d1bc73f4c82465b3f489d6737048b0cd54f22cf
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 CSMD2 NRXN1

8.51e-06161364410eef62c83c704cbfc5a1b643c4db11bbdcd81f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 CSMD2 NRXN1

8.51e-0616136471022485da6754a2b57b4c3e758e3de4c95cc292
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 CSMD2 NRXN1

8.51e-0616136459ae8a7c9a04ecaa335b8064852a5a91a21780bd
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 CSMD1 ADGRD1

8.72e-06162364c7114e24cb5525abb9780ca3d35dbcc4eabd4b64
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 CSMD1 ADGRD1

8.72e-06162364f1851a173d3bcca2981d934161ec85d1cc0af5a2
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 CSMD1 ADGRD1

8.72e-061623645d902bb31e691aea9749617cc88303c2448f24b8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANO1 PCSK2 NRXN3 CSMD1

9.15e-0616436443630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANO1 PCSK2 NRXN3 CSMD1

9.15e-06164364108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANO1 PCSK2 NRXN3 CSMD1

9.15e-0616436446208f18325976c89f572f6627aea0582142b92d
ToppCellLV-16._Neuronal|World / Chamber and Cluster_Paper

WSB1 PCSK2 NRXN3 NRXN1

9.37e-061653646ed52cb756d21addf46c7f6c457458b01339fe04
ToppCellLV-16._Neuronal|LV / Chamber and Cluster_Paper

WSB1 PCSK2 NRXN3 NRXN1

1.03e-05169364a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

PCSK2 CSMD2 NRXN1 VWDE

1.03e-05169364b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO1 GRK3 NRXN1 ADGRD1

1.05e-051703645570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellwk_20-22-Epithelial-PNS|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PCSK2 NRXN3 CSMD2 NRXN1

1.13e-0517336417b1a6b0318925d5d920f2c0a791745b9587ebef
ToppCellPCW_13-14-Neuronal-Neuronal_SCP|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PCSK2 NRXN3 CSMD2 NRXN1

1.24e-05177364621dd82f1393c961d4dd7a615aa52c9df9e36336
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK2 NRXN3 CSMD1 NRXN1

1.35e-05181364098dbb3e0ff531c9720a233123250c1e39a97d4c
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO1 GRK3 NRXN1 ADGRD1

1.41e-051833648a799807fbf24456a9811e0c64068187940a2f71
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO1 GRK3 NRXN1 ADGRD1

1.44e-05184364689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCellfacs-Heart-RV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 GRK3 NRXN1 SORL1

1.44e-0518436431dbe6119a3bcd266ae5e9b340c853d9ff680dce
ToppCellfacs-Heart-RV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO1 GRK3 NRXN1 SORL1

1.44e-051843649c20b50f8d6ac689d41d5440c835f9db8d04758b
ToppCellPCW_13-14-Neuronal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PCSK2 NRXN3 CSMD2 NRXN1

1.44e-0518436465cf3460125e3dbc34978957bc138a449f71f7df
ToppCell18-Distal-Epithelial-Neuroendocrine|Distal / Age, Tissue, Lineage and Cell class

PCSK2 NRXN1 VWDE CFAP65

1.47e-05185364f8fc7b12b4e18d23d84e95488be93c4352d325f3
ToppCellSMG-Goblet|World / shred by cell class for bronchial biopsy

ANO1 CRISP3 LRRC31 CFAP65

1.53e-051873645178118bdec91495253c88f58fd908cf831de7ef
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PCSK2 NRXN1 VWDE CFAP65

1.67e-0519136419832ddd559a353e1618fe853d79e3edfec6dcda
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine2[NE2]_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PCSK2 NRXN1 VWDE CFAP65

1.70e-051923644d3a1c267739b1479217144656986972fc86db43
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANO1 NRXN3 CSMD1 ADGRD1

1.70e-05192364b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ANO1 NRXN3 CSMD1 ADGRD1

1.70e-05192364bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PCSK2 NRXN1 VWDE CFAP65

1.74e-051933648603d1a38955ad2529d04e4704467c73ea5bfbda
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK2 MACF1 GRK3 NRXN1

1.81e-051953643e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK2 MACF1 GRK3 NRXN1

1.81e-051953647796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellTracheal-NucSeq-Stromal-Schwann-Schwann_nonmyelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK2 NRXN3 CSMD2 NRXN1

1.88e-051973645c88a97e8e23a5cd61885acbe1ef339ae6a1e35a
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NRXN3 CSMD1 CDK14 NRXN1

1.92e-05198364c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NRXN3 CSMD1 CDK14 NRXN1

1.92e-051983646d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

WSB1 NRXN3 NRXN1 TBL1XR1

1.92e-05198364de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NRXN3 CSMD1 CDK14 NRXN1

1.92e-051983644ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GPR84 VWDE ADGRD1 SORL1

2.00e-05200364838f87cc55652512d240c5952ee4b3870fb2399f
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

PCSK2 NRXN3 CSMD1 CDK14

2.00e-0520036448d801219bc771d6c7e151dc88ca4c179988de85
ToppCellCOVID-19-kidney-Epithelial_(EC)|COVID-19 / Disease (COVID-19 only), tissue and cell type

NRXN1 OR10Z1 ZSCAN5C

1.68e-04133363a8abb6b54862123961ae6defbf251ee6e9575258
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PCSK2 NRXN1 VWDE

2.04e-04142363819e983688d126d89a71abc03d72525cc759a347
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NRXN1 OR10Z1 ADGRD1

2.21e-0414636303a6a442f1f6d173a41aeebbfe41ee08853d9585
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO1 CSMD1 CSMD2

2.21e-041463632ac9b487a7991fdc15444aeb93533030e09825bb
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

CSMD1 CSMD2 NRXN1

2.21e-04146363c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellRV-16._Neuronal|World / Chamber and Cluster_Paper

PCSK2 NRXN3 NRXN1

2.35e-041493633a2f8c4173dcf9e3f8d3b8ffddbc597098adf7a9
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK3 KLHL28 SORL1

2.49e-0415236382a493ffb2f1704cd6f68a82d970fe12f537d20e
ToppCellRV-16._Neuronal|RV / Chamber and Cluster_Paper

PCSK2 NRXN3 NRXN1

2.54e-04153363bed8bbf5c5cbfbf46a816066da472c3fdddecb5d
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

CRISP3 CSMD1 CDK14

2.58e-04154363511923b27469ea20f8bd82a9ec27119a6e884644
ToppCellPCW_13-14-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

NRXN3 CSMD2 NRXN1

2.68e-041563638353f98e7d393d4299ed1da8f66cfbc7176df1b5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

2.89e-0416036314dfa519e68bab4bce890ddb66fa7763f18d9f19
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

2.89e-041603635b7789d4668ed7732babedc32d812233b430e0bd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

2.89e-04160363bba1486faaad5299e10f4fe17c6d149c28dc2560
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

2.89e-04160363839bbdfd4e4c7b48260c8bfb7670378634405e1d
ToppCellClub_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

ANO1 CRISP3 NRXN1

2.94e-04161363bd08a23b415617f6e8748ed2668d578a860ecf91
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GPR84 CRISP3 ZSCAN5A

2.94e-04161363f5da03c426f3124ea302bd343b6bca81cafee858
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_0|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GPR84 CRISP3 ZSCAN5A

3.00e-041623634e3bf16799c6552366d4c7e42b1328a05dcad7e7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

3.00e-04162363d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

3.00e-04162363eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

3.00e-041623635bbd7130d4dad9035e73a439dda568195c136f31
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

3.00e-04162363e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

3.22e-04166363f742d15b02a6f651bbd00f53e3d871f40d05a03d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell-Schwann_Cell_/_Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

3.22e-04166363e941df9a1091164edde3def8fc7d410186b2bd88
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Neural-neural_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

3.22e-04166363aeda46bea5d8463c24a83b98b9ed92d962d733e5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Neural|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK2 NRXN3 NRXN1

3.22e-041663630f013bb5fdb72e88c2fc73d60cd01551a2db6341
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CSMD1 CSMD2 NRXN1

3.28e-041673633edb0570e583bb527165bcd8a4c25a042054043b
ToppCellFetal_29-31_weeks-Epithelial-basal_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NRXN3 PER2 VWDE

3.34e-041683636521bead9789d626b86cbd08692c621c5a5aef33
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK2 GRK3 ZXDA

3.34e-04168363f45dbcd7753117a3e41e1412bce2100d52fa7fd0
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK2 NRXN3 NRXN1

3.34e-0416836395dc690c1987b05685d36e6bb20eb79308696e30
ToppCellLA-16._Neuronal|World / Chamber and Cluster_Paper

PCSK2 NRXN3 NRXN1

3.34e-041683632fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCellCOVID-19-Heart-Neuronal|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCSK2 NRXN3 NRXN1

3.34e-0416836388c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCellLA-16._Neuronal|LA / Chamber and Cluster_Paper

PCSK2 NRXN3 NRXN1

3.34e-04168363c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCellFetal_29-31_weeks-Epithelial-basal_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NRXN3 PER2 VWDE

3.39e-04169363c3ee781735a9288ce1822b230d39bb91c1415589
ToppCellfacs-SCAT-Fat-24m-Myeloid-myeloid_cell|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK2 GRK3 SORL1

3.45e-0417036313480e5f2de50425e42be0144b876e9aa4006a68
ToppCellfacs-SCAT-Fat-24m-Myeloid-nan|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK2 GRK3 SORL1

3.45e-04170363d22cd09a43a14045bb1181189fe8accf78fdde3b
ToppCellfacs-SCAT-Fat-24m-Myeloid|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK2 GRK3 SORL1

3.45e-04170363f9968d3735328a39157764343dd40f1ad8bf710d
ToppCellwk_08-11-Epithelial-Proximal_epithelial-basal_late|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

NRXN3 CSMD1 FAAH2

3.45e-0417036383320d37f0fc74e492cfe3de18f5c499eaa9fd3e
ToppCellControl-B_naive-1|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MACF1 GRK2 GRK3

3.51e-04171363d18855b24aadea38fd1e4592f945cf15b85e05f1
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK2 NRXN3 NRXN1

3.57e-04172363bc3ed05fdd94d5e1f19285aea867b1453292baec
ToppCelldroplet-Thymus-nan-3m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRK3 CDK14 NRXN1

3.63e-0417336363f03abca84ae021ff34ff34537838aa8a1ccd11
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

PCSK2 NRXN3 NRXN1

3.63e-041733636fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK2 NRXN1 ZXDA

3.63e-0417336323e50492bc673aff9df95d97f0b9be4ce57cbf01
ToppCell5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK2 NRXN3 NRXN1

3.70e-04174363c9d4e375dedd2b099a9ed70ec38ff35bbb0ce48a
ToppCellPCW_13-14-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PCSK2 NRXN3 NRXN1

3.70e-041743630d8e737860120dcd3a6b57992c612595904d585e
ToppCell5'-GW_trimst-2-LymphNode-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK2 NRXN3 NRXN1

3.70e-041743631463c98f8f519dd030587abbdbeb1b4e1bca5dd1
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

ANO1 CRISP3 NRXN3

3.70e-041743637d2f802f493f19a068e097b2909a9000e2160266
ToppCell5'-GW_trimst-2-LymphNode-Neuronal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK2 NRXN3 NRXN1

3.70e-04174363d421c0069d24cb560a3a429929e3cd1eceaeabcf
ToppCell10x3'2.3-week_17-19-Neuro-stroma-schwann_cells|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK2 NRXN3 NRXN1

3.76e-041753638b010220cdfb680ec839572f4933adfb85045ea6
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK2 NRXN1 VWDE

3.76e-041753632ce8bcf9926862e723219b4246388428d0c3fdee
ToppCell10x3'2.3-week_17-19-Neuro-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK2 NRXN3 NRXN1

3.76e-041753630b579aeadcc06be83627391c0b01bd8605fdbdf3
ToppCell10x3'2.3-week_17-19-Neuro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PCSK2 NRXN3 NRXN1

3.76e-04175363bbce8b1a160b414c0bf643c21c4e5e78fbccb7e1
ToppCellwk_20-22-Epithelial-PNS-Late_Schwann|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PCSK2 NRXN3 NRXN1

3.82e-0417636381924471d8a8c5bd8eedf294c007e25b6cd3e417
DrugSCT-1

GRK2 GRK3 CDK14

2.54e-079343CID000211458
DrugH 85

GRK2 GRK3 TG

7.73e-0626343CID006439306
DrugAC1O5WLA

GRK2 GRK3 CDK14

1.20e-0530343CID006442113
DrugbetaARKct

GRK2 GRK3

3.23e-056342CID000002295
Diseasecoronary aneurysm

NRXN3 CSMD1 CSMD2

6.72e-0635313EFO_1000881
Diseasesevere acute respiratory syndrome, COVID-19

CSMD1 NRXN1 REXO1 WRN TG

9.58e-05447315EFO_0000694, MONDO_0100096
DiseaseAutism Spectrum Disorders

NRXN3 NRXN1 NEMF

9.78e-0585313C1510586
Diseaselongevity

CSMD1 NRXN1 ADGRD1 WRN

2.15e-04284314EFO_0004300
DiseaseDepressive disorder

PER2 CSMD2 NRXN1 TG

2.30e-04289314C0011581
Diseasetemperament and character inventory

NRXN1 TG

2.91e-0424312EFO_0004825
Diseasecaudate volume change measurement, age at assessment

NRXN3 NRXN1

3.69e-0427312EFO_0008007, EFO_0021491
DiseaseParkinson's disease (biomarker_via_orthology)

GRK2 GRK3

4.56e-0430312DOID:14330 (biomarker_via_orthology)
DiseaseHVA measurement, MHPG measurement

CSMD2 NRXN1

8.13e-0440312EFO_0005131, EFO_0005133
Diseaseresponse to angiotensin-converting enzyme inhibitor, Cough

CSMD1 WRN

1.07e-0346312EFO_0005325, HP_0012735
Diseaseneuropsychological test

NRXN3 CSMD1 NRXN1

1.15e-03197313EFO_0003926
Diseaseresponse to cisplatin, platinum measurement

CSMD1 NRXN1

1.42e-0353312EFO_0010154, GO_0072718
DiseaseBipolar Disorder

GRK3 CSMD1 PER2 NRXN1

1.50e-03477314C0005586
Diseasetriacylglycerol 52:2 measurement

CSMD1 TG

1.53e-0355312EFO_0010414
Diseaseresponse to lithium ion

NRXN3 CSMD2

1.59e-0356312GO_0010226
DiseaseIGA glomerulonephritis

PSMB8 SORL1

1.70e-0358312EFO_0004194
Diseasechronotype measurement

PCSK2 NRXN3 CSMD1 PER2 NRXN1

2.10e-03882315EFO_0008328
DiseaseSchizophrenia

NRXN3 CSMD1 CSMD2 NRXN1 CFAP65

2.11e-03883315C0036341
Diseaseword reading

NRXN3 SORL1

2.13e-0365312EFO_0005300
Diseaseschizophrenia (implicated_via_orthology)

CSMD1 NRXN1

2.33e-0368312DOID:5419 (implicated_via_orthology)
Diseasejoint damage measurement

CSMD1 TG

2.33e-0368312EFO_0005413
DiseaseMental Depression

PER2 CSMD2 NRXN1

2.37e-03254313C0011570
DiseaseAutistic Disorder

NRXN3 NRXN1 TBL1XR1

2.56e-03261313C0004352
Diseasetemporal horn of lateral ventricle volume measurement

CSMD1 NRXN1

2.61e-0372312EFO_0010333
Diseasemethylcobalamin deficiency type cblE

NRXN3 VWDE

2.75e-0374312MONDO_0009354
Diseaseresponse to angiotensin-converting enzyme inhibitor

NRXN1 TG

3.05e-0378312EFO_0005325
Diseasenicotine dependence symptom count

ANO1 CSMD1 NRXN1

3.28e-03285313EFO_0009262
Diseaseage at menarche

PCSK2 CSMD1 REXO1 FAAH2

3.32e-03594314EFO_0004703
Diseaseresponse to selective serotonin reuptake inhibitor

CSMD2 ADGRD1

3.37e-0382312EFO_0005658
Diseasecongestive heart failure (is_marker_for)

GRK2 GRK3

3.37e-0382312DOID:6000 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
TAYDSSADWFSLGCM

GRK3

366

P35626
SDFRWGSSISYSCMD

CSMD1

3111

Q96PZ7
SDFMWGSSVTYACLE

CSMD2

3026

Q7Z408
LSFAMDSYGTSNNCW

ADGRD1

691

Q6QNK2
STEYSTCLDMWGVGC

CDK14

306

O94921
VAYDSSADWFSLGCM

GRK2

366

P25098
TMSGCAADCQYWERL

PSMB8

116

P28062
CAASGFTVSSNYMSW

IGHV3-66

41

A0A0C4DH42
TEAGTMALCYSAAWD

NEMF

591

O60524
SYSNIEEDCTMCPSW

CFAP65

741

Q6ZU64
WSMCSGADSFTQECM

PER2

251

O15055
YNDSICDAGWTMFCQ

LRRC31

461

Q6UY01
QQWEGFTCDCSMTSY

NRXN3

1066

Q9Y4C0
CSYWKMSSACATARA

ANO1

386

Q5XXA6
QWDGFSCDCSMTSFS

NRXN1

1101

Q9ULB1
MWNSSDANFSCYHES

GPR84

1

Q9NQS5
CTNFSSCWSDGKMFN

MACF1

216

Q9UPN3
GCAAQMFFSASWACT

OR10Z1

96

Q8NGY1
DTWLDSAGMIYCRCN

KLHL28

551

Q9NXS3
CGENLYMSSASSSWS

CRISP3

96

P54108
LGITNCSELCMWYES

FAAH2

171

Q6GMR7
MSVCSSAYSDSWQVD

KRTAP10-3

6

P60369
MSVCSSAYSDSWQVD

KRTAP10-11

6

P60412
CAASGFTVSSNYMSW

IGHV3-53

41

P01767
SGGCYQMAVTTWLSC

OR14I1

136

A6ND48
VAGGWETQYMCCSAA

REXO1

1006

Q8N1G1
DEYNCSSGMCIRSSW

SORL1

1161

Q92673
CYSMDDSEDTSWDFG

WRN

946

Q14191
WQSNNTFASCSTDMC

TBL1XR1

316

Q9BZK7
MEWGCACSPSFSSYD

VWDE

901

Q8N2E2
MAANCTSSWSLGESC

ZSCAN5A

1

Q9BUG6
LCDFDGCGWNFTSMS

ZXDA

451

P98168
WVYSCAFSPDSSMLC

WSB1

216

Q9Y6I7
SCDFYAWTSDNVACM

TG

1626

P01266
MAANCTSSWSLGESC

ZSCAN5C

1

A6NGD5
DCNCDGYASSMWTIS

PCSK2

316

P16519