Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainSPOC

SPOCD1 SPEN

6.48e-054622PS50917
DomainSPOC_C

SPOCD1 SPEN

1.61e-046622IPR012921
DomainSPOC

SPOCD1 SPEN

1.61e-046622PF07744
DomainHECT

ITCH WWP2

3.61e-0327622PF00632
DomainHECTc

ITCH WWP2

3.61e-0327622SM00119
DomainHECT_dom

ITCH WWP2

3.61e-0327622IPR000569
DomainHECT

ITCH WWP2

3.61e-0327622PS50237
Pubmed

Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.

DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

1.11e-191272810433963
Pubmed

Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy.

DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

2.88e-191372817668377
Pubmed

The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

9.64e-19872717588759
Pubmed

DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

1.44e-171072717984056
Pubmed

Characterization of a tandemly repeated 3.3-kb KpnI unit in the facioscapulohumeral muscular dystrophy (FSHD) gene region on chromosome 4q35.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

2.05e-16137277739628
Pubmed

Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements.

DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

2.31e-151772711245978
Pubmed

The transcription factor Duxbl mediates elimination of pre-T cells that fail β-selection.

PTCRA DUX4L9 DUX4L2 DUX4L4

5.88e-10772430765463
Pubmed

The homeobox transcription factor DUXBL controls exit from totipotency.

DUX4L9 DUX4L2 DUX4L4

3.40e-08472338509386
Pubmed

Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development.

DUX4L9 DUX4L2 DUX4L4

3.40e-08472317911620
Pubmed

Characterization of genomic structures and expression profiles of three tandem repeats of a mouse double homeobox gene: Duxbl.

DUX4L9 DUX4L2 DUX4L4

8.48e-08572320063414
Pubmed

Mutations in MINAR2 encoding membrane integral NOTCH2-associated receptor 2 cause deafness in humans and mice.

DUX4L9 DUX4L2 DUX4L4

3.80e-061572335727972
Pubmed

Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.

DUX4L9 DUX4L2 DUX4L4

3.80e-061572330071041
Pubmed

Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production.

TERT EDN1

4.23e-06272216831983
Pubmed

Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex.

NFX1 TERT

4.23e-06272215371341
Pubmed

NFX1-123 is highly expressed in cervical cancer and increases growth and telomerase activity in HPV 16E6 expressing cells.

NFX1 TERT

4.23e-06272230776478
Pubmed

Defective regulation of microRNA target genes in myoblasts from facioscapulohumeral dystrophy patients.

DUX4L9 DUX4

4.23e-06272224145033
Pubmed

NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes.

NFX1 TERT

4.23e-06272219369336
Pubmed

NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.

NFX1 TERT

1.27e-05372218505829
Pubmed

Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner.

ITCH WWP2

1.27e-05372219997087
Pubmed

Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.

ITCH WWP2

1.27e-05372212450395
Pubmed

Involvement of the NFX1-repressor complex in PKC-δ-induced repression of hTERT transcription.

NFX1 TERT

1.27e-05372227311997
Pubmed

The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR.

ITCH WWP2

1.27e-05372229925997
Pubmed

Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans.

TERT PRRC2A

1.27e-05372223221128
Pubmed

DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation.

DUX4L9 DUX4

2.53e-05472219829708
Pubmed

Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43.

ITCH WWP2

2.53e-05472220522958
Pubmed

MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5.

MICAL3 EDN1

2.53e-05472225403488
Pubmed

Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.

ITCH WWP2

2.53e-05472226701932
Pubmed

Paip1, an effective stimulator of translation initiation, is targeted by WWP2 for ubiquitination and degradation.

WWP2 EIF3A

4.21e-05572225266661
Pubmed

RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy.

DUX4L2 DUX4

4.21e-05572219359275
Pubmed

A Tunable Brake for HECT Ubiquitin Ligases.

ITCH WWP2

4.21e-05572228475870
Pubmed

N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.

ITCH WWP2

6.31e-05672215252135
Pubmed

Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.

ITCH WWP2

6.31e-05672237156795
Pubmed

Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.

ITCH WWP2

6.31e-0567229647693
Pubmed

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.

ITCH WWP2

6.31e-05672211748237
Pubmed

Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.

ITCH WWP2

8.82e-05772231845480
Pubmed

Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage.

NES TERT

8.82e-05772217409236
Pubmed

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.

ITCH WWP2

8.82e-05772211046148
Pubmed

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.

ITCH WWP2

8.82e-05772223644597
Pubmed

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

ITCH WDR33 EIF3A PRRC2A SEC23A

9.59e-0522072524550385
Pubmed

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.

WDR33 EIF3A PRRC2A

9.89e-054372334672947
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

BCL9L HMCN2 SIPA1L3 EIF3A SPEN PRRC2A

1.05e-0436172626167880
Pubmed

Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation.

RRAD ZNHIT2 SEC23A

1.13e-044572334504087
Pubmed

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.

ITCH WWP2

1.17e-04872219307600
Pubmed

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.

ITCH WWP2

1.17e-04872211244092
Pubmed

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.

ITCH WWP2

1.17e-04872217719543
Pubmed

Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.

ITCH WWP2

1.17e-04872231578285
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

ZNF512B ITCH WDR33 WWP2 SIPA1L3 ZNF746 PRRC2A SEC23A SNAP29

1.19e-0492272927609421
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

DUX4L9 DUX4L2 DUX4L4

1.55e-045072331806660
Pubmed

Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.

ITCH WWP2

1.88e-041072225092867
Pubmed

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

NFX1 RNF25

2.30e-041172210500182
Pubmed

ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.

ITCH WWP2

2.30e-041172234927784
Pubmed

Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.

ITCH WWP2

2.30e-041172217996703
Pubmed

Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding.

ITCH WWP2

2.30e-041172221191027
Pubmed

USP11 augments TGFβ signalling by deubiquitylating ALK5.

ITCH WWP2

2.30e-041172222773947
Pubmed

Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.

ITCH WWP2

2.30e-041172225963657
Pubmed

Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.

PSORS1C2 ARMC9

2.75e-041272223955597
Pubmed

Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis.

NES NEURL2

2.75e-041272214960280
Pubmed

Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.

ITCH WWP2

3.25e-041372220858735
Pubmed

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.

ITCH WWP2

3.78e-041472231015455
Pubmed

HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.

ITCH WWP2

3.78e-041472226147758
Pubmed

The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.

SEC23A SNAP29

3.78e-041472231806350
Pubmed

Analysis of several hundred genetic polymorphisms may improve assessment of the individual genetic burden for coronary artery disease.

EDN1 CYBA

4.36e-041572212446192
Pubmed

DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex.

DCLK3 CYP7B1

4.36e-041572225556833
Pubmed

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.

ITCH WWP2

4.36e-041572223236378
Pubmed

Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.

ITCH WWP2

4.98e-041672225723849
Pubmed

A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

ITCH WWP2

4.98e-041672222496338
Pubmed

RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.

ITCH WWP2

5.63e-041772228292929
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

RBSN GTF3C2 WWP2 CTDP1 SPEN PRRC2A

6.19e-0450372616964243
Pubmed

SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.

ITCH WWP2

7.06e-041972221572392
Pubmed

Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.

BICRA CYP7B1

7.84e-042072222174851
Pubmed

Interaction network of human early embryonic transcription factors.

ZNF512B BCL9L BICRA ZNF746 SPEN

8.19e-0435172538297188
Pubmed

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

ITCH WWP2

8.65e-042172237005481
Pubmed

ARRDC1 and ARRDC3 act as tumor suppressors in renal cell carcinoma by facilitating YAP1 degradation.

ITCH WWP2

8.65e-042172229416926
Pubmed

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.

ITCH WWP2

9.50e-042272224850914
Pubmed

Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.

NES PRSS33

1.04e-032372228289129
Pubmed

TIM-1 Ubiquitination Mediates Dengue Virus Entry.

ITCH WWP2

1.04e-032372229742433
Pubmed

WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.

ITCH WWP2 PRRC2A

1.09e-039772325071155
Pubmed

Gene network analysis in a pediatric cohort identifies novel lung function genes.

WDR33 MICAL3

1.13e-032472224023788
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

ITCH WWP2

1.33e-032672226949039
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

CTDP1 MICAL3 PRRC2A

1.33e-0310472331240132
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HIVEP3 BICRA SIPA1L3 CTDP1 NFX1 MICAL3 SPEN PLEKHH3

2.01e-03110572835748872
Pubmed

NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.

NFX1 TERT

2.01e-033272217267499
Pubmed

An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.

RBSN WWP2

2.01e-033272228388416
CytobandEnsembl 112 genes in cytogenetic band chr4q35

DUX4L9 DUX4L2 DUX4 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7 FAM149A

2.47e-13117729chr4q35
Cytoband4q35.2

DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

3.47e-12277264q35.2
GeneFamilyPRD class homeoboxes and pseudogenes

DUX4L9 DUX4L2 DUX4L5 DUX4L6 DUX4L3 DUX4L4 DUX4L7

2.30e-0992447521
DrugDoxycycline hydrochloride [10592-13-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A

NES LMF1 BICRA CTDP1 NFX1 RNF25 PRRC2A

2.99e-061977277195_DN
Diseasecentral nervous system cancer, glioblastoma multiforme

LMF1 TERT

3.89e-0414622EFO_0000326, EFO_0000519
DiseaseNephrosis

NES EDN1

4.48e-0415622C0027720
DiseaseRenal Insufficiency

EDN1 CYBA

5.79e-0417622C1565489
DiseaseHIV-1 infection, Susceptibility to viral and mycobacterial infections

BICRA CYP7B1

8.89e-0421622EFO_0000180, Orphanet_391311
DiseaseKidney Failure

EDN1 CYBA

9.77e-0422622C0035078
Diseaseglioma

LMF1 TERT

9.77e-0422622EFO_0005543
Diseasenephrosis (biomarker_via_orthology)

NES EDN1

9.77e-0422622DOID:2527 (biomarker_via_orthology)
Diseasemonocyte count

TTLL12 HIVEP3 CEBPD ZNF746 CTDP1 ARMC9 NYAP1 PEAR1 SNAP29

1.67e-031320629EFO_0005091
Diseaseobstructive sleep apnea (is_marker_for)

EDN1 CYBA

1.70e-0329622DOID:0050848 (is_marker_for)
Diseasecentral nervous system cancer, glioma

LMF1 TERT

1.70e-0329622EFO_0000326, EFO_0005543

Protein segments in the cluster

PeptideGeneStartEntry
PYRDLWEPPRPGGER

CCDC185

11

Q8N715
PRPGKPDERDIWPPA

CTDP1

396

Q9Y5B0
WEDPGPRLRNPLERP

CCDC187

551

A0A096LP49
ESRPWPGRRGPPEGR

DUX4L4

81

P0CJ87
APRWPPHPGKSREDR

DUX4L4

256

P0CJ87
ESRPWPGRRGPPEGR

DUX4L6

81

P0CJ89
APRWPPHPGKSREDR

DUX4L6

256

P0CJ89
GEEWERRPQEPRPPK

CPXM2

66

Q8N436
RRGPAPLRKAEGWLP

RBSN

431

Q9H1K0
RELTPWAGRPPGPRR

NRTN

71

Q99748
ERRRGSTPWGPAPPL

RRAD

21

P55042
RDRRWGDTPPGRKPG

PTCRA

216

Q6ISU1
PRLPPSDLGGVPWKE

MICAL3

951

Q7RTP6
ESRPWPGRRGPPEGR

DUX4

81

Q9UBX2
APRWPPHPGKSREDR

DUX4

256

Q9UBX2
PGRKWRKLGLPPVSP

FAM149A

431

A5PLN7
PGAPESRGLWLPRRP

KCNK15

266

Q9H427
GIPPPAIRWFRGEEP

HMCN2

2386

Q8NDA2
KPGEWLPRGRQEEPR

ARMC9

716

Q7Z3E5
GRGKWEPEPSSKPPR

DCLK3

96

Q9C098
WTPIEPKPRERPQIG

CYBA

131

P13498
ESRPWPGRRGPPEGR

DUX4L3

81

P0CJ86
APRWPPHPGKSREDR

DUX4L3

256

P0CJ86
ADWKHRREPPPGPLD

PEAR1

866

Q5VY43
PPWEVEGARPRPGRN

NFX1

246

Q12986
ELPGKSRDPWEPPRE

NES

1156

P48681
PWGAGRERQPVPPRA

NALF2

81

O75949
PLWGGPPDSPRRELE

P3H2

21

Q8IVL5
GSLRPGVPLPEWRPL

PRSS33

166

Q8NF86
GALWGLERPEPPPTR

NEURL2

11

Q9BR09
ESPPAPRAGPREVWK

OTOP2

11

Q7RTS6
RPEPLPPGWERRVDN

ITCH

356

Q96J02
PGPAAPRLLKREPDW

CEBPD

111

P49716
GDDSRPGPWRPLVKP

EIF3A

1161

Q14152
PGPWRPLVKPGGWRE

EIF3A

1166

Q14152
WLRRGPGGPPLWERP

CCDC166

271

P0CW27
ESRPWPGRRGPPEGR

DUX4L9

81

Q6RFH8
APRWPPHPGKSREDR

DUX4L9

256

Q6RFH8
RPVRPGMGWTEDLPP

BCL9L

631

Q86UU0
ESRPWPGRRGPPEGR

DUX4L7

81

P0CJ90
APRWPPHPGKSREDR

DUX4L7

256

P0CJ90
RPKPRREDSPAGAPW

MAMSTR

211

Q6ZN01
REDSPAGAPWPRLKP

MAMSTR

216

Q6ZN01
GGRPNELEPPMPTWR

FAM98C

316

Q17RN3
REGQDPGRWPRTTPP

C2orf81

501

A6NN90
RRPGEPPLIKGWLPY

CYP7B1

41

O75881
ESRPWPGRRGPPEGR

DUX4L5

81

P0CJ88
APRWPPHPGKSREDR

DUX4L5

256

P0CJ88
DPDWEAPGLPPAKRR

BICRA

1461

Q9NZM4
GEKPTPSPPWRLRRS

EDN1

36

P05305
RGPKDPLQWLGSPPR

CABP2

11

Q9NPB3
ILPSWRRGPEPRKSG

NYAP1

811

Q6ZVC0
GRSLPKAVRPPLSWP

SOHLH1

231

Q5JUK2
PRGGGARPWLPPRRA

PLEKHH3

106

Q7Z736
VRWRALPGLPRPPGL

NFAM1

6

Q8NET5
WGPRPGSSRRGIPPE

PRRC2A

926

P48634
RPAPWRDARDLPDGP

SNAP29

21

O95721
PTGWKRTEEPPPRPL

SIPA1L3

1456

O60292
SGPPRLGPWERPTEL

KDF1

11

Q8NAX2
DTGSPRKPWPERRPP

SSC5D

981

A1L4H1
RWGPDHSRGKSPPRP

SYCE2

171

Q6PIF2
PWPVPQGKRPLRSSG

SEC23A

251

Q15436
PLPPGWEKRTDPRGR

WWP2

331

O00308
PAETLKPPEGWRSPR

SPEN

1971

Q96T58
WQRPPRGRGRLWPEP

SPOCD1

1086

Q6ZMY3
KGPGSWQGPPPRRTR

RNF25

401

Q96BH1
RRPWSPSKEAGSRPP

HIVEP3

1966

Q5T1R4
VTWGPTRKEPAPGPR

PIGZ

196

Q86VD9
RRAGGPEGPPWLPRT

TTLL12

376

Q14166
PVAKLPPRRDDWPPG

ZNF512B

856

Q96KM6
PPRRDDWPPGCRDKG

ZNF512B

861

Q96KM6
ELERLWGGPVPPAPR

ZNHIT2

381

Q9UHR6
WELPGTPRKAPLLPR

GTF3C2

481

Q8WUA4
NWRRPGPKIPDVPVD

ZNF746

156

Q6NUN9
PPPSRASWAREGRPL

VSIG10L

606

Q86VR7
QEEKWRRGGPGPPFP

WDR33

1041

Q9C0J8
ASLPPRKRPWHDGPG

WDR33

1226

Q9C0J8
PRPVWPDPKLEGGAR

ZNF831

776

Q5JPB2
LGSRPWMPGTPRRLP

TERT

366

O14746
LRWDRDEGPPPAKLP

nan

266

A6NL46
PLPSWGAPPLRDRAR

ZCCHC12

286

Q6PEW1
PTRPSRPWRDLPETG

PSORS1C2

66

Q9UIG4
ESRPWPGRRGPPEGR

DUX4L2

81

P0CJ85
APRWPPHPGKSREDR

DUX4L2

256

P0CJ85
NPFAGRPPPRWVRGE

LMF1

501

Q96S06