Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	ubiquitin-dependent protein catabolic process via the N-end rule pathway	UBR2 UBR4	4.02e-05	4	54	2	GO:0071596
GeneOntologyBiologicalProcess	attachment of GPI anchor to protein	PIGS PGAP1	1.00e-04	6	54	2	GO:0016255
GeneOntologyBiologicalProcess	positive regulation of mast cell cytokine production	SYK KIT	1.00e-04	6	54	2	GO:0032765
GeneOntologyBiologicalProcess	small intestine smooth muscle contraction	SCN11A KIT	1.00e-04	6	54	2	GO:1990770
GeneOntologyCellularComponent	guanyl-nucleotide exchange factor complex	CCZ1B CCZ1 RIC1	3.74e-05	24	57	3	GO:0032045
GeneOntologyCellularComponent	C-fiber	SCN11A SCN10A	4.37e-05	4	57	2	GO:0044299
GeneOntologyCellularComponent	Mon1-Ccz1 complex	CCZ1B CCZ1	7.27e-05	5	57	2	GO:0035658
Domain	ZnF_C2HC	FAM90A14 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10	1.56e-10	55	52	7	SM00343
Domain	Znf_CCHC	FAM90A14 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10	1.56e-10	55	52	7	IPR001878
Domain	DUF1712	CCZ1B CCZ1	7.60e-06	2	52	2	PF08217
Domain	DUF1712_fun	CCZ1B CCZ1	7.60e-06	2	52	2	IPR013176
Domain	zf-UBR	UBR2 UBR4	1.58e-04	7	52	2	PF02207
Domain	Znf_UBR	UBR2 UBR4	1.58e-04	7	52	2	IPR003126
Domain	TLV_coat	ERVV-2 ERVV-1	1.58e-04	7	52	2	PF00429
Domain	ZnF_UBR1	UBR2 UBR4	1.58e-04	7	52	2	SM00396
Domain	ZF_UBR	UBR2 UBR4	1.58e-04	7	52	2	PS51157
Domain	TLV/ENV_coat_polyprotein	ERVV-2 ERVV-1	2.11e-04	8	52	2	IPR018154
Domain	Na_channel_asu	SCN11A SCN10A	3.37e-04	10	52	2	IPR001696
Domain	Na_trans_assoc	SCN11A SCN10A	3.37e-04	10	52	2	IPR010526
Domain	Na_trans_assoc	SCN11A SCN10A	3.37e-04	10	52	2	PF06512
Domain	Channel_four-helix_dom	CACNA1S SCN11A SCN10A	5.36e-04	57	52	3	IPR027359
Domain	-	CACNA1S SCN11A SCN10A	5.36e-04	57	52	3	1.20.120.350
Domain	CT	GREM2 SLIT3	1.69e-03	22	52	2	SM00041
Domain	Cys_knot_C	GREM2 SLIT3	2.19e-03	25	52	2	IPR006207
Domain	CTCK_2	GREM2 SLIT3	2.19e-03	25	52	2	PS01225
Domain	EGF_Ca-bd_CS	HMCN1 SLIT3 CRB2	2.50e-03	97	52	3	IPR018097
Domain	EGF_CA	HMCN1 SLIT3 CRB2	2.64e-03	99	52	3	PS01187
Domain	EGF-type_Asp/Asn_hydroxyl_site	HMCN1 SLIT3 CRB2	3.21e-03	106	52	3	IPR000152
Domain	Ion_trans_dom	CACNA1S SCN11A SCN10A	3.94e-03	114	52	3	IPR005821
Domain	Ion_trans	CACNA1S SCN11A SCN10A	3.94e-03	114	52	3	PF00520
Domain	EGF_3	HMCN1 SLIT3 ADAM22 CRB2	4.12e-03	235	52	4	PS50026
Domain	EGF	HMCN1 SLIT3 ADAM22 CRB2	4.12e-03	235	52	4	SM00181
Domain	EGF_CA	HMCN1 SLIT3 CRB2	4.76e-03	122	52	3	SM00179
Domain	EGF-like_Ca-bd_dom	HMCN1 SLIT3 CRB2	4.98e-03	124	52	3	IPR001881
Domain	LAM_G_DOMAIN	SLIT3 CRB2	5.01e-03	38	52	2	PS50025
Domain	EGF-like_dom	HMCN1 SLIT3 ADAM22 CRB2	5.06e-03	249	52	4	IPR000742
Domain	EGF	HMCN1 SLIT3 CRB2	5.21e-03	126	52	3	PF00008
Domain	EGF_1	HMCN1 SLIT3 ADAM22 CRB2	5.50e-03	255	52	4	PS00022
Domain	Laminin_G_2	SLIT3 CRB2	5.54e-03	40	52	2	PF02210
Domain	EGF-like_CS	HMCN1 SLIT3 ADAM22 CRB2	5.96e-03	261	52	4	IPR013032
Domain	EGF_2	HMCN1 SLIT3 ADAM22 CRB2	6.29e-03	265	52	4	PS01186
Domain	LamG	SLIT3 CRB2	6.67e-03	44	52	2	SM00282
Domain	Laminin_G	SLIT3 CRB2	1.14e-02	58	52	2	IPR001791
Pathway	REACTOME_ATTACHMENT_OF_GPI_ANCHOR_TO_UPAR	PIGS PGAP1	1.11e-04	7	33	2	M26984
Pathway	REACTOME_ATTACHMENT_OF_GPI_ANCHOR_TO_UPAR	PIGS PGAP1	1.11e-04	7	33	2	MM14622
Pubmed	Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	1.52e-30	25	60	13	17684299
Pubmed	Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P FAM90A7 FAM90A9 FAM90A8 FAM90A16 FAM90A10	2.03e-25	23	60	11	18602769
Pubmed	Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A26 FAM90A23 FAM90A1 FAM90A7 FAM90A9 FAM90A8 FAM90A10	5.12e-15	164	60	11	22967998
Pubmed	Heat-resistant action potentials require TTX-resistant sodium channels NaV1.8 and NaV1.9.	SCN11A SCN10A	2.93e-06	2	60	2	29970412
Pubmed	Tetrodotoxin-resistant voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 are expressed in the retina.	SCN11A SCN10A	2.93e-06	2	60	2	18399542
Pubmed	Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas.	SCN11A SCN10A	2.93e-06	2	60	2	24144460
Pubmed	Staphylococcus δ-toxin induces allergic skin disease by activating mast cells.	SYK KIT	2.93e-06	2	60	2	24172897
Pubmed	SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors.	DBNL SYK	2.93e-06	2	60	2	9891087
Pubmed	Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.	ERVV-2 ERVV-1	2.93e-06	2	60	2	18826608
Pubmed	Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves.	SCN11A SCN10A	2.93e-06	2	60	2	28450535
Pubmed	Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice.	SCN11A SCN10A	2.93e-06	2	60	2	19931571
Pubmed	Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons.	SCN11A SCN10A	2.93e-06	2	60	2	34930944
Pubmed	Dissecting the role of sodium currents in visceral sensory neurons in a model of chronic hyperexcitability using Nav1.8 and Nav1.9 null mice.	SCN11A SCN10A	2.93e-06	2	60	2	16857712
Pubmed	The Nav1.9 channel is a key determinant of cold pain sensation and cold allodynia.	SCN11A SCN10A	2.93e-06	2	60	2	25959819
Pubmed	Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache.	SCN11A SCN10A	2.93e-06	2	60	2	31534133
Pubmed	Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.	ERVV-2 ERVV-1	2.93e-06	2	60	2	23555306
Pubmed	A disease mutation reveals a role for NaV1.9 in acute itch.	SCN11A SCN10A	8.77e-06	3	60	2	30395542
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	8.77e-06	3	60	2	32160108
Pubmed	Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria.	SCN11A SCN10A	8.77e-06	3	60	2	38999942
Pubmed	Yield of peripheral sodium channels gene screening in pure small fibre neuropathy.	SCN11A SCN10A	8.77e-06	3	60	2	30554136
Pubmed	A fundamental role of mAbp1 in neutrophils: impact on beta(2) integrin-mediated phagocytosis and adhesion in vivo.	DBNL SYK	1.75e-05	4	60	2	19638624
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR2 UBR4	1.75e-05	4	60	2	16055722
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR2 UBR4	1.75e-05	4	60	2	19008229
Pubmed	Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells.	SYK KIT	1.75e-05	4	60	2	17993265
Pubmed	Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.	CCZ1B CCZ1	1.75e-05	4	60	2	20305638
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	CCZ1B PI4KA PIGS APBB1 TMEM131L ADAM22 RIC1	2.56e-05	504	60	7	34432599
Pubmed	Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells.	SYK KIT	2.92e-05	5	60	2	25017467
Pubmed	Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.	SCN11A SCN10A	2.92e-05	5	60	2	37117223
Pubmed	Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia.	SKOR2 SCN10A SRP68	3.07e-05	35	60	3	38025786
Pubmed	Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.	SCN11A SCN10A	4.37e-05	6	60	2	16029194
Pubmed	An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.	SCN11A SCN10A	4.37e-05	6	60	2	23711479
Pubmed	Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.	ERVV-2 ERVV-1	4.37e-05	6	60	2	23085571
Pubmed	The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.	UBR4 CDC6	6.11e-05	7	60	2	34893540
Pubmed	Pain without nociceptors? Nav1.7-independent pain mechanisms.	SCN11A SCN10A	6.11e-05	7	60	2	24440715
Pubmed	Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol.	PIGS PGAP1	6.11e-05	7	60	2	1846368
Pubmed	A role for Piezo2 in EPAC1-dependent mechanical allodynia.	SCN11A SCN10A	6.11e-05	7	60	2	23575686
Pubmed	C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation.	SCN10A KIT	8.14e-05	8	60	2	37699522
Pubmed	S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.	SCN10A KIT	8.14e-05	8	60	2	37995657
Pubmed	Syncytins expressed in human placental trophoblast.	ERVV-2 ERVV-1	8.14e-05	8	60	2	33504453
Pubmed	Significant determinants of mouse pain behaviour.	SCN11A SCN10A	8.14e-05	8	60	2	25101983
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1S SCN11A SCN10A KCNIP2	1.00e-04	139	60	4	16985003
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN11A SCN10A	1.05e-04	9	60	2	16382098
Pubmed	Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.	RPS6KA5 SYK	1.05e-04	9	60	2	20362473
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR2 UBR4	1.05e-04	9	60	2	17855541
Pubmed	Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.	SCN10A KIT	1.31e-04	10	60	2	33098765
Pubmed	Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.	SYK KIT	1.91e-04	12	60	2	10872802
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR2 UBR4	1.91e-04	12	60	2	17360488
Pubmed	Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome.	SCN11A SCN10A	3.03e-04	15	60	2	33722956
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	SCN11A SCN10A	4.40e-04	18	60	2	31666509
Pubmed	Regulation of developmental lymphangiogenesis by Syk(+) leukocytes.	MPO SYK	4.40e-04	18	60	2	20230750
Pubmed	Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.	SCN11A TTC21A	4.91e-04	19	60	2	24564958
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CCZ1B CCZ1 ERO1A PI4KA PGAP1 DBNL TMEM131L CDCP1	5.28e-04	1084	60	8	11544199
Pubmed	ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.	SCN11A SCN10A	6.02e-04	21	60	2	25369838
Pubmed	Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.	SCN11A SCN10A	7.23e-04	23	60	2	16446141
Pubmed	A protein interaction landscape of breast cancer.	UBR2 PI4KA UBR4 SRP68 KPNA6 MTREX	7.79e-04	634	60	6	34591612
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	CACNA1S UBR4 SCN10A RIC1 SOS2	8.82e-04	430	60	5	35044719
Pubmed	Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.	UBR2 RPS6KA5 SYK	1.13e-03	118	60	3	24453475
Pubmed	Atypical E2F repressors and activators coordinate placental development.	ERO1A CDC6	1.49e-03	33	60	2	22516201
Pubmed	KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.	UBR2 UBR4	1.49e-03	33	60	2	25582440
Pubmed	Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves.	SCN11A SCN10A	1.68e-03	35	60	2	18498732
Interaction	FAM90A26 interactions	FAM90A26 FAM90A1	5.10e-06	2	46	2	int:FAM90A26
Cytoband	8p23.1	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	1.60e-18	154	60	12	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	FAM90A14 FAM90A17 FAM90A19 FAM90A22 FAM90A23 FAM90A2P FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10	2.61e-16	234	60	12	chr8p23
Cytoband	3p22.2	SCN11A TTC21A SCN10A	4.21e-06	24	60	3	3p22.2
Cytoband	7p22.1	CCZ1B CCZ1	1.75e-03	47	60	2	7p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3p22	SCN11A TTC21A SCN10A	1.83e-03	184	60	3	chr3p22
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR2 UBR4	3.84e-05	7	25	2	785
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN11A SCN10A	6.57e-05	9	25	2	1203
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ERO1A FAM90A26 SYK KIT ADAM22	9.26e-07	161	49	5	176a4a72bb4892932da3c834d1fea5e211847f92
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|Classical_Monocyte / Disease condition and Cell class	CERKL SPATA17 ERO1A TMEM131L MTREX	1.40e-06	175	49	5	35ea2ed93538e6bf803029fcf7d9243f93e7733d
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_1\|COVID-19_Severe / Disease condition and Cell class	CERKL SPATA17 ERO1A TMEM131L MTREX	1.65e-06	181	49	5	0d07a67e8ee3bca687b378afbc4044434e63556d
ToppCell	Ciliated_cells-B-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	CFAP47 CERKL TTC21A APBB1	3.33e-05	166	49	4	4b1056aad8a99827835242b8ab0c7f2bb84471f1
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CERKL ERO1A SYK TMEM131L	3.41e-05	167	49	4	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CERKL HMCN1 CCZ1 KIT	4.09e-05	175	49	4	c58a1f02d1e559d3638fe1500e960e82a8a7187b
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 CACNA1S SPATA17 CRB2	4.37e-05	178	49	4	579cdc14f28b459e200ae2102e0bd4df8a2c0dcb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 CACNA1S SPATA17 CRB2	4.37e-05	178	49	4	b1db59344c074c7c80169fc2c5cd5fc89f3fe463
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 CACNA1S SPATA17 CRB2	4.86e-05	183	49	4	18040d0653286071df959513c63d94b555a5d00a
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 CACNA1S SPATA17 CRB2	4.86e-05	183	49	4	6ca7c2d7c56e0f1b9038ba677b4c1c3dfd63bfce
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO ERO1A TTC21A CDC6	5.07e-05	185	49	4	53854a9ec87c24c360541c83d86d8fafb303ad58
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPO ERO1A TTC21A CDC6	5.07e-05	185	49	4	a61fc7a3700a1efcf640bef7680c0443ee148a46
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 CERKL SPATA17 TTC21A	5.07e-05	185	49	4	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	Mild-NK\|World / Disease group and Cell class	SLIT3 SYK CDCP1 KIT	5.07e-05	185	49	4	0565b7c464e1a09e596f5a0b363d2dc9b55c3c50
ToppCell	P15-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PLB1 APBB1 TMC4 C16orf89	5.18e-05	186	49	4	521e6e007bbae73e7328153aa170cf04ca3c1093
ToppCell	P28-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PLB1 APBB1 TMC4 C16orf89	5.29e-05	187	49	4	a4b41904ba05eb76212c949fc3ac197f906c8351
ToppCell	COVID-19-lung-Ciliated\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CFAP47 CERKL SPATA17 TTC21A	5.51e-05	189	49	4	a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCell	ASK440-Mesenchymal-Fibroblast\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	MPO HMCN1 PGAP1 SLIT3	5.74e-05	191	49	4	387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCell	ASK440-Mesenchymal\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	MPO HMCN1 PGAP1 SLIT3	5.74e-05	191	49	4	f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBR2 UBR4 MTREX C16orf89	5.86e-05	192	49	4	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLB1 DBNL TMC4 KIT	6.22e-05	195	49	4	25703e3c2e0512ef12e7aa389fad3968c3f13905
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	CERKL PI4KA KPNA6 KIT	6.35e-05	196	49	4	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	NS-moderate-d_0-4-Epithelial-Ciliated\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP47 CERKL SPATA17 TTC21A	6.47e-05	197	49	4	71fea4aa6ce96c7693fa94792d08770622873850
ToppCell	LPS_anti-TNF-Epithelial_airway\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SPATA17 ERVV-2 TMC4 C16orf89	6.73e-05	199	49	4	6aca164bbbb961f34b1e6f1857f91ade5c059405
ToppCell	LPS_anti-TNF-Epithelial_airway-airway_epithelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SPATA17 ERVV-2 TMC4 C16orf89	6.73e-05	199	49	4	60919c2af31d39a2d36d7bc432e43dab2a4e05fb
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CFAP47 CERKL SPATA17 TTC21A	6.86e-05	200	49	4	31d75c26055177d656df1fbb10b764cebd61e122
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CFAP47 CERKL SPATA17 TTC21A	6.86e-05	200	49	4	e1dce91c6c531bb212002a14705e496d77ad3490
Disease	PAROXYSMAL EXTREME PAIN DISORDER	SCN11A SCN10A	6.51e-06	3	44	2	C1833661
Disease	Primary Erythermalgia	SCN11A SCN10A	6.51e-06	3	44	2	C0014805
Disease	Hereditary Sensory Autonomic Neuropathy, Type 5	SCN11A SCN10A	4.54e-05	7	44	2	C0020075
Disease	Congenital Pain Insensitivity	SCN11A SCN10A	4.54e-05	7	44	2	C0002768
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN11A SCN10A	9.71e-05	10	44	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN11A SCN10A	9.71e-05	10	44	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN11A SCN10A	1.42e-04	12	44	2	DOID:0060170 (implicated_via_orthology)
Disease	male infertility (implicated_via_orthology)	CFAP47 KIT	1.68e-04	13	44	2	DOID:12336 (implicated_via_orthology)
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1	1.96e-04	14	44	2	DOID:3753 (implicated_via_orthology)
Disease	Chronic myeloproliferative disorder	CDC6 KIT	3.66e-04	19	44	2	C1292778
Disease	interstitial lung disease (is_marker_for)	MPO KIT	6.38e-04	25	44	2	DOID:3082 (is_marker_for)
Disease	QRS duration	HMCN1 SKOR2 UBR4 SCN10A	1.01e-03	298	44	4	EFO_0005055
Disease	social communication impairment	SCN11A SCN10A	1.05e-03	32	44	2	EFO_0005427

Protein segments in the cluster

Peptide	Gene	Start	Entry
AFVGPKLPQVKLFRP	nan	101	Q75L30
QPLPPGFKRFSCLSL	LINC00596	71	Q86U02
LQPLPPGFKQFSCLI	C16orf89	336	Q6UX73
PRPVKQSRKFVPGCF	CDCP1	361	Q9H5V8
GACLFNKPSKLLDPP	ADAM22	431	Q9P0K1
PPGYVFLCGPQKNKL	ERVV-2	251	B6SEH9
EKLPPRNTNPGIKCF	APBB1	356	O00213
APIQACLNFPKKPRL	FAM90A10	296	A6NDY2
CLNFPKKPRLGPFQI	FAM90A10	301	A6NDY2
QRKLLPFCPPVVLAQ	RIC1	701	Q4ADV7
APIQACLNFPKKPRL	FAM90A7	296	A6NKC0
CLNFPKKPRLGPFQI	FAM90A7	301	A6NKC0
TPYGPFPCKAINKIL	LLGL1	281	Q15334
APIQACLNFPKKPRL	FAM90A23	296	A8MXZ1
CLNFPKKPRLGPFQI	FAM90A23	301	A8MXZ1
NLCRGKNPPPEFAKV	KPNA6	236	O60684
CQGKPLPKDLRFIPD	KIT	151	P10721
QFCEVAKGLPLPLPF	CRB2	1206	Q5IJ48
APIQACLNFPKKPRL	FAM90A1	296	Q86YD7
CLNFPKKPRLGPFQI	FAM90A1	301	Q86YD7
CLLKKPFNRPQGVQP	SYK	101	P43405
PPGYVFLCGPQKNKL	ERVV-1	251	B6SEH8
APIQACLNFPKKPRL	FAM90A22	296	A8MWA6
CLNFPKKPRLGPFQI	FAM90A22	301	A8MWA6
APIQACLNFPKKPRL	FAM90A14	296	P0C7W9
CLNFPKKPRLGPFQI	FAM90A14	301	P0C7W9
CFPLKIPPNDPRIKN	MPO	291	P05164
KQRFLKLLPCCGPQA	KCNIP2	36	Q9NS61
FSCPPKFPTQGEKRL	PI4KA	1386	P42356
FGFARLKPPDNQPLK	RPS6KA5	566	O75582
APIQACLNFPKKPRL	FAM90A17	296	P0DV74
CLNFPKKPRLGPFQI	FAM90A17	301	P0DV74
APIQACLNFPKKPRL	FAM90A16	296	P0DV73
CLNFPKKPRLGPFQI	FAM90A16	301	P0DV73
ECPGLDPPFRLKKIQ	GREM2	136	Q9H772
KRPAQAPIQACLKFP	FAM90A19	291	P0DV76
CLKFPKKPRLGPFQI	FAM90A19	301	P0DV76
NQRIEFPCPAKGTPK	HMCN1	1281	Q96RW7
APIQACLNFPKKPRL	FAM90A8	296	A6NJQ4
CLNFPKKPRLGPFQI	FAM90A8	301	A6NJQ4
FLKQFPCPPNSPKAV	PUS10	261	Q3MIT2
LRRIQPPLGFGKFCP	CACNA1S	1426	Q13698
PLNLNDPDAKCRFPK	CCZ1	286	P86791
PLNLNDPDAKCRFPK	CCZ1B	286	P86790
GFPNRPKSLKILLNP	CERKL	161	Q49MI3
QAREKCKPQLLNFPP	CDC6	331	Q99741
ENCFKPQTIKRPLNP	ERO1A	206	Q96HE7
APIQACLNFPKKPRL	FAM90A20P	296	A6NIJ5
CLNFPKKPRLGPFQI	FAM90A20P	301	A6NIJ5
APIQACLNFPKKPRL	FAM90A5P	296	A8MXJ8
CLNFPKKPRLGPFQI	FAM90A5P	301	A8MXJ8
PLQFLPLQSGRYPCK	CFAP47	2281	Q6ZTR5
PQPGKLRSPFLQKQL	DBNL	276	Q9UJU6
APIQACLNFPKKPRL	FAM90A24P	296	P0C7X0
CLNFPKKPRLGPFQI	FAM90A24P	301	P0C7X0
LFGIAQPQLPPKCLL	PIGS	396	Q96S52
LLAPYQACLIPPKKG	PARS2	366	Q7L3T8
ILPPINRKQCQGPFR	SPATA17	231	Q96L03
KLKSINPPCVPFFGI	SOS2	916	Q07890
KILNFTGPLFLPPGC	TMEM131L	436	A2VDJ0
APIQACLNFPKKPRL	FAM90A12P	296	A8MX19
CLNFPKKPRLGPFQI	FAM90A12P	301	A8MX19
APIQACLNFPKKPRL	FAM90A9	296	A6NNJ1
CLNFPKKPRLGPFQI	FAM90A9	301	A6NNJ1
APIQACLNFPKKPRL	FAM90A13P	296	P0C7W8
CLNFPKKPRLGPFQI	FAM90A13P	301	P0C7W8
APIQACLNFPKKPRL	FAM90A26	296	D6RGX4
CLNFPKKPRLGPFQI	FAM90A26	301	D6RGX4
KLNPDPCKPLAFILI	PGAP1	846	Q75T13
LKNSPFPCNPNKLGV	PLB1	41	Q6P1J6
APIQACLNFPKKPRL	FAM90A15P	296	P0C7V4
CLNFPKKPRLGPFQI	FAM90A15P	301	P0C7V4
FQPIPCKPLFFDLAL	SRP68	581	Q9UHB9
EFKEFVGLPCKNRPP	ACD	371	Q96AP0
GNPRCQKPFFLKEIP	SLIT3	686	O75094
KPKYCLPFLQPGRLV	MTREX	646	P42285
KPIPRPLNKFQGFVF	SCN10A	1456	Q9Y5Y9
FLIPPSKLCGPFRGQ	TMC4	611	Q7Z404
RPAQAPIQGCLNFPK	FAM90A2P	291	Q658T7
PIQGCLNFPKKPRLG	FAM90A2P	296	Q658T7
LNFPKKPRLGPFQIP	FAM90A2P	301	Q658T7
LLFCPKQPRLPGQIV	TTC21A	466	Q8NDW8
LCKSFLGENRPPKLP	SKOR2	126	Q2VWA4
KPIPRPLNKCQGLVF	SCN11A	1346	Q9UI33
VPKIYCRGPNPFPQK	UBR2	46	Q8IWV8
KPKNAFLAPACLPGL	UBR4	2636	Q5T4S7
KRPAQAPIQACLKFP	FAM90A18	291	P0DV75
CLKFPKKPRLGPFQI	FAM90A18	301	P0DV75