Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	AMP binding	PRPS2 PFKL PFKP PRPS1	2.02e-07	21	50	4	GO:0016208
GeneOntologyMolecularFunction	6-phosphofructokinase activity	PFKL PFKP	1.84e-05	3	50	2	GO:0003872
GeneOntologyMolecularFunction	ribose phosphate diphosphokinase activity	PRPS2 PRPS1	6.12e-05	5	50	2	GO:0004749
GeneOntologyMolecularFunction	fructose-6-phosphate binding	PFKL PFKP	6.12e-05	5	50	2	GO:0070095
GeneOntologyMolecularFunction	diphosphotransferase activity	PRPS2 PRPS1	9.16e-05	6	50	2	GO:0016778
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PRPS2 MAP4K3 FER DGKA EEF2K PRKDC PFKL REV3L PFKP PRPS1	9.23e-05	938	50	10	GO:0016772
GeneOntologyMolecularFunction	kinase activity	PRPS2 MAP4K3 FER DGKA EEF2K PRKDC PFKL PFKP PRPS1	1.03e-04	764	50	9	GO:0016301
GeneOntologyMolecularFunction	phosphofructokinase activity	PFKL PFKP	1.28e-04	7	50	2	GO:0008443
GeneOntologyMolecularFunction	carbohydrate binding	PRPS2 CRYBG2 PFKL PFKP PRPS1	1.04e-03	310	50	5	GO:0030246
GeneOntologyMolecularFunction	carbohydrate kinase activity	PFKL PFKP	1.25e-03	21	50	2	GO:0019200
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	MAP4K3 FER DGKA EEF2K PRKDC PFKL PFKP	1.83e-03	709	50	7	GO:0016773
GeneOntologyMolecularFunction	dicarboxylic acid transmembrane transporter activity	SLC25A18 SLC26A9	2.73e-03	31	50	2	GO:0005310
GeneOntologyBiologicalProcess	5-phosphoribose 1-diphosphate metabolic process	PRPS2 PRPS1	7.91e-05	6	48	2	GO:0046391
GeneOntologyBiologicalProcess	5-phosphoribose 1-diphosphate biosynthetic process	PRPS2 PRPS1	7.91e-05	6	48	2	GO:0006015
GeneOntologyBiologicalProcess	nicotinamide nucleotide metabolic process	PRPS2 HAAO PFKL PFKP PRPS1	1.04e-04	202	48	5	GO:0046496
GeneOntologyBiologicalProcess	pyridine nucleotide metabolic process	PRPS2 HAAO PFKL PFKP PRPS1	1.04e-04	202	48	5	GO:0019362
GeneOntologyBiologicalProcess	pyridine-containing compound metabolic process	PRPS2 HAAO PFKL PFKP PRPS1	1.25e-04	210	48	5	GO:0072524
GeneOntologyCellularComponent	6-phosphofructokinase complex	PFKL PFKP	1.68e-05	3	50	2	GO:0005945
GeneOntologyCellularComponent	ribose phosphate diphosphokinase complex	PRPS2 PRPS1	5.58e-05	5	50	2	GO:0002189
GeneOntologyCellularComponent	transferase complex	PRPS2 ZYG11A PRKDC PFKL REV3L PFKP SMC5 USP47 FBXW7 PRPS1	7.86e-05	963	50	10	GO:1990234
GeneOntologyCellularComponent	transferase complex, transferring phosphorus-containing groups	PRPS2 PRKDC PFKL REV3L PFKP PRPS1	1.42e-04	335	50	6	GO:0061695
GeneOntologyCellularComponent	fascia adherens	NRAP VCL	4.30e-04	13	50	2	GO:0005916
GeneOntologyCellularComponent	intercalated disc	AKAP6 NRAP VCL	5.78e-04	68	50	3	GO:0014704
GeneOntologyCellularComponent	DNA repair complex	PRKDC ASCC3	1.37e-03	23	50	2	GO:1990391
GeneOntologyCellularComponent	cell-cell contact zone	AKAP6 NRAP VCL	1.48e-03	94	50	3	GO:0044291
Domain	PHOSPHOFRUCTOKINASE	PFKL PFKP	2.19e-05	3	51	2	PS00433
Domain	6-Pfructokinase_euk	PFKL PFKP	2.19e-05	3	51	2	IPR009161
Domain	PRPP_SYNTHASE	PRPS2 PRPS1	2.19e-05	3	51	2	PS00114
Domain	Phosphofructokinase_CS	PFKL PFKP	2.19e-05	3	51	2	IPR015912
Domain	PFK	PFKL PFKP	2.19e-05	3	51	2	PF00365
Domain	PRib_PP_synth_CS	PRPS2 PRPS1	2.19e-05	3	51	2	IPR000842
Domain	ATP_PFK	PFKL PFKP	2.19e-05	3	51	2	IPR022953
Domain	Phosphofructokinase_dom	PFKL PFKP	2.19e-05	3	51	2	IPR000023
Domain	Rib-P_diPkinase	PRPS2 PRPS1	7.27e-05	5	51	2	IPR005946
Domain	Pribosyltran_N	PRPS2 PRPS1	7.27e-05	5	51	2	IPR029099
Domain	Pribosyltran_N	PRPS2 PRPS1	7.27e-05	5	51	2	PF13793
Domain	Pribosyl_synth	PRPS2 PRPS1	7.27e-05	5	51	2	PF14572
Domain	Pribosyltran	PRPS2 PRPS1	3.96e-04	11	51	2	PF00156
Domain	PRTase-like	PRPS2 PRPS1	4.74e-04	12	51	2	IPR029057
Domain	PRibTrfase_dom	PRPS2 PRPS1	4.74e-04	12	51	2	IPR000836
Domain	-	PRPS2 PRPS1	4.74e-04	12	51	2	3.40.50.2020
Pathway	KEGG_PENTOSE_PHOSPHATE_PATHWAY	PRPS2 PFKL PFKP PRPS1	9.30e-07	27	40	4	M1386
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	DDX50 SEC24B PRKDC PFKL PFKP PRPS1	2.80e-07	182	51	6	32239614
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MXRA5 PKHD1 AHR DGKA SLC26A9 PRKDC PFKL REV3L PFKP	1.11e-06	736	51	9	29676528
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	CRYL1 IPO9 SEC24B AHR FAM83D PRKDC PFKL ASCC3 PFKP VCL GSPT1	1.54e-06	1247	51	11	27684187
Pubmed	[Increased activity of PRPP synthetase].	PRPS2 PRPS1	2.11e-06	2	51	2	18409517
Pubmed	FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7.	FAM83D FBXW7	2.11e-06	2	51	2	24344117
Pubmed	L-fucose reduces gut inflammation due to T-regulatory response in Muc2 null mice.	PRKDC MUC2	2.11e-06	2	51	2	36584066
Pubmed	PRPS1-mediated purine biosynthesis is critical for pluripotent stem cell survival and stemness.	PRPS2 PRPS1	2.11e-06	2	51	2	33493137
Pubmed	Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1.	PKHD1 PRKDC	2.11e-06	2	51	2	24984783
Pubmed	Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript.	PRPS2 PRPS1	2.11e-06	2	51	2	2537655
Pubmed	FAM83D promotes the progression of 4NQO-induced esophageal carcinoma via inhibiting FBWX7.	FAM83D FBXW7	2.11e-06	2	51	2	39260674
Pubmed	Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.	DRD2 ANKS1B SLC26A9	4.49e-06	22	51	3	21107309
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PRPS2 FAM184B SLC25A18 DDX50 PKHD1 ANKS1B DGKA PRKDC PFKP GSPT1 PRPS1	6.19e-06	1442	51	11	35575683
Pubmed	Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.	PFKL PFKP	6.32e-06	3	51	2	33141153
Pubmed	Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.	PRPS2 PRPS1	6.32e-06	3	51	2	25816608
Pubmed	Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues.	PFKL PFKP	6.32e-06	3	51	2	156693
Pubmed	Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms.	PRPS2 PRPS1	6.32e-06	3	51	2	1314091
Pubmed	Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency.	PFKL PFKP	6.32e-06	3	51	2	7825568
Pubmed	Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system.	PFKL PFKP	6.32e-06	3	51	2	6451249
Pubmed	Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions.	PRPS2 PRPS1	6.32e-06	3	51	2	9366267
Pubmed	Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system.	PFKL PFKP	6.32e-06	3	51	2	6444721
Pubmed	Genomic organization, 5'flanking region and tissue-specific expression of mouse phosphofructokinase C gene.	PFKL PFKP	6.32e-06	3	51	2	11137296
Pubmed	FAM83D knockdown regulates proliferation, migration and invasion of colorectal cancer through inhibiting FBXW7/Notch-1 signalling pathway.	FAM83D FBXW7	6.32e-06	3	51	2	28407575
Pubmed	Characterization of the enzymatic defect in late-onset muscle phosphofructokinase deficiency. New subtype of glycogen storage disease type VII.	PFKL PFKP	6.32e-06	3	51	2	2960695
Pubmed	Molecular mechanism of c-Myc and PRPS1/2 against thiopurine resistance in Burkitt's lymphoma.	PRPS2 PRPS1	6.32e-06	3	51	2	32391636
Pubmed	Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes.	PRPS2 PRPS1	6.32e-06	3	51	2	1962753
Pubmed	Phosphofructokinase isozyme expression during myoblast differentiation.	PFKL PFKP	6.32e-06	3	51	2	2521854
Pubmed	Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase.	PRPS2 PRPS1	6.32e-06	3	51	2	26175007
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	GSDME IPO9 PRKDC PFKL PFKP	7.37e-06	183	51	5	23956138
Pubmed	Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks.	NRAP VCL	1.26e-05	4	51	2	10320340
Pubmed	Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.	PRKDC FBXW7	1.26e-05	4	51	2	20823234
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	GSDME IPO9 ASCC3 VCL GSPT1	1.64e-05	216	51	5	31519766
Pubmed	Linkage of phosphoribosylpyrophosphate synthetases 1 and 2, Prps1 and Prps2, on the mouse X chromosome.	PRPS2 PRPS1	2.10e-05	5	51	2	7849396
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	IPO9 DDX50 MAP4K3 SEC24B PRKDC PFKL ASCC3 PFKP VCL GSPT1	2.29e-05	1353	51	10	29467282
Pubmed	Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.	PRPS2 PFKL PFKP PRPS1	2.43e-05	114	51	4	28245920
Pubmed	GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease.	MAP4K3 AHR	3.15e-05	6	51	2	30214937
Pubmed	Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.	PRPS2 PRPS1	3.15e-05	6	51	2	24855946
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	PRPS2 IPO9 PRKDC PFKL ASCC3 PFKP VCL GSPT1 PRPS1	3.96e-05	1149	51	9	35446349
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	PRPS2 IPO9 EEF2K PRKDC PFKL PFKP VCL USP47 GSPT1 PRPS1	4.24e-05	1455	51	10	22863883
Pubmed	Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart.	NRAP VCL	7.54e-05	9	51	2	11732910
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	FER FAM83D PFKL ASCC3 SMC5 VCL GSPT1	8.60e-05	724	51	7	36232890
Pubmed	TGFβ pathway is required for viable gestation of Fanconi anemia embryos.	PRKDC VCL	9.42e-05	10	51	2	36441774
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	PRKDC PFKP FBXW7	1.11e-04	63	51	3	37052853
Pubmed	Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.	PRKDC PFKL PFKP	1.16e-04	64	51	3	22865885
Pubmed	LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.	MAP4K3 PRKDC PFKL PFKP VCL	1.17e-04	327	51	5	31409639
Pubmed	Defining human ERAD networks through an integrative mapping strategy.	IPO9 PRKDC PFKL PFKP	1.23e-04	173	51	4	22119785
Pubmed	IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.	AHR PRKDC	1.90e-04	14	51	2	23853597
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	PRKDC USP47 PRPS1	1.94e-04	76	51	3	27542412
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	IPO9 DDX50 DHCR24 PRKDC PFKL ASCC3 PFKP GSPT1 PRPS1	2.20e-04	1440	51	9	30833792
Pubmed	Functional proteomics mapping of a human signaling pathway.	PLEKHB2 KIF18A CPXM2 PFKL ASCC3 VCL	2.21e-04	591	51	6	15231748
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	IPO9 PRKDC PFKL ASCC3 PFKP FBXW7	2.42e-04	601	51	6	33658012
Pubmed	SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity.	USP47 FBXW7	2.50e-04	16	51	2	29891922
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	SEC24B PFKL PFKP VCL GSPT1 PRPS1	2.55e-04	607	51	6	39147351
Pubmed	Defining the membrane proteome of NK cells.	IPO9 DDX50 DHCR24 DGKA PRKDC PFKL ASCC3 PFKP	2.79e-04	1168	51	8	19946888
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	IPO9 PRKDC REV3L	2.89e-04	87	51	3	17148452
Pubmed	Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching.	PFKL PFKP	3.18e-04	18	51	2	28049690
Pubmed	Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.	PRPS2 PFKL PRPS1	3.51e-04	93	51	3	27215380
Pubmed	The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.	VCL FBXW7	3.55e-04	19	51	2	22405651
Pubmed	Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.	PFKL VCL	3.94e-04	20	51	2	21270129
Pubmed	The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.	PRKDC ASCC3 PFKP SMC5	4.09e-04	237	51	4	29564676
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	KIF18A PFKL PFKP GKN1 PRPS1	4.20e-04	431	51	5	33660365
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	PLEKHB2 IPO9 DHCR24 SEC24B PRKDC ASCC3 PFKP	4.29e-04	942	51	7	31073040
Pubmed	Network organization of the human autophagy system.	SEC24B PRKDC PFKL PFKP GSPT1	4.47e-04	437	51	5	20562859
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	PRPS2 SLC25A18 DDX50 PRKDC PFKL PFKP PRPS1	4.48e-04	949	51	7	36574265
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	PRPS2 DHCR24 PRKDC PFKL ASCC3 PFKP GSPT1 PRPS1	4.55e-04	1257	51	8	37317656
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	DDX50 DHCR24 PRKDC PRPS1	5.22e-04	253	51	4	29911972
Pubmed	IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.	AHR PRKDC	5.23e-04	23	51	2	34473953
Pubmed	GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism.	GSDME PFKP	6.19e-04	25	51	2	32913122
Pubmed	Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.	DRD2 PKHD1	6.19e-04	25	51	2	28154160
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PRPS2 IPO9 DDX50 PRKDC PFKL ASCC3 GSPT1 PRPS1	6.22e-04	1318	51	8	30463901
Pubmed	DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC.	VCL FBXW7 PRPS1	7.04e-04	118	51	3	37105989
Pubmed	Role of the E3 ubiquitin-ligase Hakai in intestinal inflammation and cancer bowel disease.	PRKDC VCL	7.23e-04	27	51	2	36266428
Pubmed	AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.	MXRA5 PKHD1 PRKDC	7.57e-04	121	51	3	31900314
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	PRPS2 DHCR24 FAM83D ASCC3 PRPS1	8.43e-04	503	51	5	36217030
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	PRKDC PFKL	8.93e-04	30	51	2	32867711
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	PRKDC ASCC3 FBXW7	9.12e-04	129	51	3	23022380
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	PRKDC PFKL PFKP VCL	9.62e-04	298	51	4	30737378
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AKAP6 FAM184B DDX50 MAP4K3 DGKA PFKL KDM1B	9.81e-04	1084	51	7	11544199
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	PRPS2 DNAJC19 DHCR24 PRKDC PFKL PFKP GSPT1 PRPS1	9.87e-04	1415	51	8	28515276
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	IPO9 DDX50 DHCR24 PRKDC PFKL VCL GSPT1 PRPS1	1.03e-03	1425	51	8	30948266
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	SEC24B FER ASCC3 GSPT1	1.28e-03	322	51	4	39098523
Pubmed	The genetic architecture of economic and political preferences.	AKAP6 ASCC3	1.36e-03	37	51	2	22566634
Pubmed	USP11 mediates repair of DNA-protein cross-links by deubiquitinating SPRTN metalloprotease.	PRPS2 IPO9 PRKDC PFKL PFKP	1.41e-03	565	51	5	33567341
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	DDX50 DHCR24 SEC24B FAM83D PFKL KDM1B ASCC3 PFKP	1.41e-03	1497	51	8	31527615
Pubmed	Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples.	DRD2 AHR	1.43e-03	38	51	2	14634838
Interaction	KDF1 interactions	DDX50 SEC24B PRKDC PFKL PFKP PRPS1	8.72e-06	192	51	6	int:KDF1
Cytoband	7p15	GSDME AHR	1.09e-04	14	51	2	7p15
Cytoband	1p32.3	ZYG11A DHCR24	2.12e-03	61	51	2	1p32.3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAP4K3 FER PKHD1 PFKP VCL	2.83e-06	194	51	5	46070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MAP4K3 FER PKHD1 PFKP VCL	2.83e-06	194	51	5	abacb6a8d7a9003f2f6c2be0305507f1c1c50347
Drug	AC1L1AO2	PRPS2 PFKL PFKP PRPS1	6.68e-08	18	51	4	CID000001073
Drug	2,5-anhydro-D-mannitol	PRPS2 PFKL PFKP PRPS1	6.72e-07	31	51	4	CID000001494
Drug	allulose 6-phosphate	PRPS2 MAP4K3 PKHD1 PFKL PFKP PRPS1	1.63e-06	162	51	6	CID000000603
Drug	isochroman	DRD2 AHR FBXW7	3.79e-06	14	51	3	CID000096266
Drug	Quinolinic Acid	DRD2 AHR HAAO	8.44e-06	18	51	3	ctd:D017378
Drug	Uridine diphosphate 2-deoxyglucose	PFKL PFKP	2.94e-05	4	51	2	CID000165519
Drug	anthranilic acid	PRPS2 AHR HAAO PRPS1	4.74e-05	89	51	4	CID000000227
Drug	AC1L9828	PRPS2 PRPS1	4.90e-05	5	51	2	CID000439794
Drug	declopramide	DRD2 PRKDC	4.90e-05	5	51	2	CID000070177
Drug	6-o-phosphonohexose	PRPS2 PFKL PFKP FBXW7 PRPS1	5.82e-05	185	51	5	CID000099058
Drug	acetyl phosphate	MAP4K3 OXCT2 PFKL PFKP	6.91e-05	98	51	4	CID000000186
Drug	APP-MP	PRPS2 PRPS1	7.34e-05	6	51	2	CID003081102
Drug	pyrimidine-5-nucleotide	PRPS2 PRPS1	7.34e-05	6	51	2	CID000440040
Drug	AC1MIX9B	PFKL PFKP	7.34e-05	6	51	2	CID003081623
Drug	methyl iodoacetate	PRPS2 PRPS1	7.34e-05	6	51	2	CID006429536
Drug	benzo(f)quinoline	DRD2 AHR	7.34e-05	6	51	2	ctd:C039108
Drug	Esculin Hydrate [531-75-9]; Up 200; 11.8uM; MCF7; HT_HG-U133A	CRYBG2 GSDME HAAO CASP10 GSPT1	7.84e-05	197	51	5	5411_UP
Drug	Hexylcaine hydrochloride [532-76-3]; Up 200; 13.4uM; PC3; HT_HG-U133A	DRD2 ANXA10 HAAO CASP10 VCL	7.84e-05	197	51	5	5768_UP
Drug	glipentide	PFKL PFKP	1.03e-04	7	51	2	CID000065779
Drug	dactylarin	PFKL PFKP	1.03e-04	7	51	2	CID000161389
Disease	glycogen storage disease (implicated_via_orthology)	PFKL PFKP	1.68e-05	4	50	2	DOID:2747 (implicated_via_orthology)
Disease	Tobacco Dependence	DRD2 AHR	2.53e-04	14	50	2	C0040332
Disease	Nicotine Dependence	DRD2 AHR	2.53e-04	14	50	2	C0028043
Disease	Nicotine Use Disorder	DRD2 AHR	2.53e-04	14	50	2	C0376384
Disease	smoking behavior	NRAP CPXM2 PKHD1 REV3L ASCC3	2.77e-04	341	50	5	EFO_0004318
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	AKAP6 DRD2 GSDME ANKS1B	3.70e-04	200	50	4	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Disease	Tachyarrhythmia	DRD2 AHR	4.23e-04	18	50	2	C0080203
Disease	Tachycardia	DRD2 AHR	4.23e-04	18	50	2	C0039231
Disease	disease of metabolism (implicated_via_orthology)	PFKL PFKP	5.79e-04	21	50	2	DOID:0014667 (implicated_via_orthology)
Disease	Adenocarcinoma of large intestine	EEF2K PRKDC FBXW7	5.85e-04	96	50	3	C1319315
Disease	Weight Gain	DRD2 AHR PRPS1	6.99e-04	102	50	3	C0043094
Disease	alcohol use disorder measurement, alcohol dependence	DRD2 PKHD1	7.58e-04	24	50	2	EFO_0009458, MONDO_0007079
Disease	Squamous cell carcinoma of lung	MAP4K3 PRKDC	1.35e-03	32	50	2	C0149782
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	AKAP6 NRAP CPXM2 PRKDC REV3L ASCC3	2.26e-03	801	50	6	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	unipolar depression, bipolar disorder	DRD2 GSDME ASCC3	2.37e-03	156	50	3	EFO_0003761, MONDO_0004985
Disease	schizophrenia (is_marker_for)	DRD2 HAAO	2.54e-03	44	50	2	DOID:5419 (is_marker_for)
Disease	bipolar disorder	AKAP6 KIF18A DRD2 GSDME ANKS1B	2.88e-03	577	50	5	MONDO_0004985
Disease	smoking status measurement	DRD2 NRAP CPXM2 PKHD1 ANKS1B REV3L ASCC3	3.25e-03	1160	50	7	EFO_0006527

Protein segments in the cluster

Peptide	Gene	Start	Entry
VVEPQQQLCQKMKHM	AHR	631	P35869
IINPHEKVQMKSICA	ERI2	286	A8K979
QKTGEHKTMLQMILC	ANXA10	186	Q9UJ72
PVCNKLMHQEQLKVM	HAAO	21	P46952
KITTMQKCVISEHMQ	GSDME	161	O60443
QLMKVVNEMCPNITR	CPXM2	326	Q8N436
VVKMIISAHPNLMSC	ANKS1B	176	Q7Z6G8
AVVQQEIIMMKDCKH	MAP4K3	56	Q8IVH8
EIIMMKDCKHPNIVA	MAP4K3	61	Q8IVH8
VNFMLHKCQMKKPIT	MAGEB16	121	A2A368
PMDMVNIRHAKKAQT	NRAP	631	Q86VF7
MEHKRNICKINPSMV	KIF18A	871	Q8NI77
DPQMHVKMCKKIAQL	FAM184B	31	Q9ULE4
QTCSKVMMHIRNHPV	ECHDC3	126	Q96DC8
QEVLIKTVHMMPMQV	MUC2	4546	Q02817
LPLMECVQMTKEVQK	PFKL	346	P17858
PLMECVQMTQDVQKA	PFKP	356	Q01813
CMDLKVHPEQEKLMT	FAM83D	206	Q9H4H8
PCTIKITHKNQMPML	DGKA	706	P23743
ICKGQQLVMMPNKHN	GSPT1	326	P15170
CIVHKMNKEVMPSIQ	GKN1	81	Q9NS71
PVALMCEQLGISMHK	KDM1B	446	Q8NB78
APQHCPEDISKIMMK	FER	781	P16591
QVVVTCPMEMLKIQL	SLC25A18	116	Q9H1K4
HHVVQDMLVPMKCLQ	DHCR24	381	Q15392
TQVSCSPLEMMKKHV	CRYBG2	866	Q8N1P7
LIDSCEPTQVKHMMQ	FBXW7	256	Q969H0
CETKKNVTEMAMNPH	DDX50	396	Q9BQ39
VKNFPKHMVSSMQQI	IPO9	276	Q96P70
EMEMVLQKQKCNPAH	CASP10	331	Q92851
MKKIGQCPMRVQKEV	CRYL1	176	Q9Y2S2
HKPPKQVDIMQMCII	EEF2K	201	O00418
HPEDMKLCTVIMKSN	DRD2	246	P14416
AMCQIKSQPLVHLMK	SEC24B	1101	O95487
KVHMPMDCINIRTGQ	PLEKHB2	46	Q96CS7
CKMPKKYHMQIVGEI	SLC26A9	301	Q7LBE3
RMKVMLGKVNQCPHQ	PKHD1	3931	P08F94
VTMQHCTKDNTPKIM	OXCT2	436	Q9BYC2
PMIMKQSQSEKAHVE	AKAP6	1481	Q13023
KVKQCVHQIPSVMME	ASCC3	1171	Q8N3C0
EKMQSVQKMFKCHPD	PLEKHS1	81	Q5SXH7
VQKMFKCHPDEVMSI	PLEKHS1	86	Q5SXH7
MLQCTPANMVEVHKD	REV3L	346	O60673
PQEDKMKHCTKIQVI	PRPS2	276	P11908
NIKRNEMVTKHPVMC	ZNF679	76	Q8IYX0
KCKVAMANIQPQMLV	VCL	736	P18206
LFCLHPTKQVMMENK	USP47	611	Q96K76
VMAHLPDVCVNLMKA	PRKDC	1391	P78527
PQEDKMKHCSKIQVI	PRPS1	276	P60891
VCEPIMLTINMKDNK	SMC5	481	Q8IY18
MKHMEPQVKQVFQSL	DNAJC19	26	Q96DA6
CKHENPKMQTMAVSV	ZYG11A	476	Q6WRX3
HGNMVNLVCDIKKPM	MXRA5	326	Q9NR99