Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	TTYH1 SLC25A20 SLC11A2 SLC38A9 CYB561D2 MCL1 AQP4 SLC47A2 SLC22A12 CLCNKB SLC12A9 SLC16A1 SLC27A1 CACNG4 ATP1A3 TIMM22 SLC7A10 ABCC10	5.24e-05	1180	107	18	GO:0022857
GeneOntologyMolecularFunction	molecular sensor activity	PMS2P1 SLC38A9 NOX4 MICU3	1.48e-04	50	107	4	GO:0140299
GeneOntologyMolecularFunction	transporter activity	TTYH1 SLC25A20 SLC11A2 SLC38A9 CYB561D2 MCL1 AQP4 SLC47A2 SLC22A12 CLCNKB SLC12A9 SLC16A1 SLC27A1 CACNG4 ATP1A3 TIMM22 SLC7A10 ABCC10	1.61e-04	1289	107	18	GO:0005215
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	MAP3K1 MOS MAP3K19	3.98e-04	27	107	3	GO:0004709
GeneOntologyCellularComponent	Cul3-RING ubiquitin ligase complex	KLHL2 KEAP1 KLHL3 KLHL7 KLHL12	1.53e-06	39	106	5	GO:0031463
GeneOntologyCellularComponent	mitochondrial membrane	USP30 SLC25A20 SLC11A2 MCL1 ZNFX1 RDH13 CPS1 MICU3 SLC27A1 ALAS1 TMEM223 HERC2 TIMM22 PINK1	1.21e-04	866	106	14	GO:0031966
GeneOntologyCellularComponent	mitochondrial envelope	USP30 SLC25A20 SLC11A2 MCL1 ZNFX1 RDH13 CPS1 MICU3 SLC27A1 ALAS1 TMEM223 HERC2 TIMM22 PINK1	2.07e-04	912	106	14	GO:0005740
Domain	Kelch_1	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHDC1 KLHL7 KLHDC8A KLHL23 KLHL12 KLHL33	1.89e-13	70	106	11	PF01344
Domain	Kelch_1	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHDC1 KLHL7 KLHDC8A KLHL23 KLHL12 KLHL33	1.89e-13	70	106	11	IPR006652
Domain	Kelch	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL7 KLHDC8A KLHL23 KLHL12 KLHL33	9.35e-13	58	106	10	SM00612
Domain	BACK	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL7 KLHL23 KLHL12 KLHL33	5.03e-11	60	106	9	SM00875
Domain	BACK	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL7 KLHL23 KLHL12 KLHL33	5.87e-11	61	106	9	PF07707
Domain	BACK	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL7 KLHL23 KLHL12 KLHL33	5.87e-11	61	106	9	IPR011705
Domain	BTB-kelch_protein	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL7 KLHL23 KLHL12 KLHL33	1.01e-10	43	106	8	IPR017096
Domain	Gal_Oxase/kelch_b-propeller	KLHL2 KEAP1 KLHL3 KLHL5 KLHDC1 KLHDC8A KLHL23 KLHL12	1.44e-09	59	106	8	IPR011043
Domain	-	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL12	7.78e-09	27	106	6	2.130.10.80
Domain	Kelch-typ_b-propeller	KEAP1 KLHL5 KLHDC1 KLHL7 KLHDC8A KLHL23 KLHL33	2.52e-08	55	106	7	IPR015915
Domain	Gal_Oxidase_b-propeller	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL12	3.42e-08	34	106	6	IPR015916
Domain	BTB	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL7 KLHL23 KLHL12 KLHL33	3.20e-07	160	106	9	PS50097
Domain	BTB	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL7 KLHL23 KLHL12	8.01e-07	131	106	8	PF00651
Domain	SKP1/BTB/POZ	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL7 KLHL23 KLHL12 KLHL33	1.30e-06	189	106	9	IPR011333
Domain	BTB	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL7 KLHL23 KLHL12	8.60e-06	180	106	8	SM00225
Domain	BTB/POZ_dom	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL7 KLHL23 KLHL12	1.05e-05	185	106	8	IPR000210
Domain	-	KLHDC1 KLHL7 KLHDC8A KLHL33	1.57e-04	48	106	4	2.120.10.80
Domain	HECT	AREL1 HERC2 HERC6	4.71e-04	27	106	3	PF00632
Domain	HECTc	AREL1 HERC2 HERC6	4.71e-04	27	106	3	SM00119
Domain	HECT_dom	AREL1 HERC2 HERC6	4.71e-04	27	106	3	IPR000569
Domain	HECT	AREL1 HERC2 HERC6	4.71e-04	27	106	3	PS50237
Domain	PROTEIN_KINASE_DOM	ADCK5 RPS6KB2 IRAK1 MAP3K1 CDKL5 STRADA ROS1 MOS PINK1 MAP3K19	4.96e-04	493	106	10	PS50011
Domain	Kinase-like_dom	ADCK5 RPS6KB2 IRAK1 MAP3K1 CDKL5 STRADA ROS1 MOS PINK1 MAP3K19	1.03e-03	542	106	10	IPR011009
Domain	PROTEIN_KINASE_ATP	ADCK5 RPS6KB2 IRAK1 MAP3K1 CDKL5 ROS1 MOS PINK1 MAP3K19	1.21e-03	459	106	9	PS00107
Domain	Pkinase	RPS6KB2 IRAK1 MAP3K1 CDKL5 STRADA MOS PINK1 MAP3K19	1.48e-03	381	106	8	PF00069
Domain	Prot_kinase_dom	RPS6KB2 IRAK1 MAP3K1 CDKL5 STRADA ROS1 MOS PINK1 MAP3K19	1.87e-03	489	106	9	IPR000719
Domain	ATP-grasp	CPS1 SUCLA2	2.78e-03	14	106	2	IPR011761
Domain	ATP_GRASP	CPS1 SUCLA2	2.78e-03	14	106	2	PS50975
Domain	-	CPS1 SUCLA2	3.19e-03	15	106	2	3.30.1490.20
Domain	Laminin_N	LAMA2 USH2A	3.64e-03	16	106	2	IPR008211
Domain	LAMININ_NTER	LAMA2 USH2A	3.64e-03	16	106	2	PS51117
Domain	Laminin_N	LAMA2 USH2A	3.64e-03	16	106	2	PF00055
Domain	LamNT	LAMA2 USH2A	3.64e-03	16	106	2	SM00136
Domain	Ser/Thr_kinase_AS	RPS6KB2 IRAK1 MAP3K1 CDKL5 MOS PINK1 MAP3K19	4.25e-03	357	106	7	IPR008271
Domain	S_TKc	RPS6KB2 IRAK1 MAP3K1 CDKL5 MOS PINK1 MAP3K19	4.38e-03	359	106	7	SM00220
Domain	PROTEIN_KINASE_ST	RPS6KB2 IRAK1 MAP3K1 CDKL5 MOS PINK1 MAP3K19	4.59e-03	362	106	7	PS00108
Domain	ATP_grasp_subdomain_1	CPS1 SUCLA2	4.60e-03	18	106	2	IPR013815
Domain	-	CPS1 SUCLA2	4.60e-03	18	106	2	3.30.470.20
Domain	RCC1	HERC2 HERC6	5.67e-03	20	106	2	PF00415
Domain	Protein_kinase_ATP_BS	RPS6KB2 IRAK1 MAP3K1 CDKL5 ROS1 MOS MAP3K19	5.86e-03	379	106	7	IPR017441
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	TTYH1 MBTPS1 SLC11A2 PEX3 AQP4 SLC47A2 SLC22A12 MICU3 CLCNKB SLC16A1 LIPG SLC27A1 ATP1A3 SLC7A10 ABCC10	2.23e-05	736	83	15	M27287
Pubmed	Update on the Kelch-like (KLHL) gene family.	KLHL2 KEAP1 KLHL3 KLHL5 KLHL7 KLHL23 KLHL12 KLHL33	6.28e-13	41	109	8	23676014
Pubmed	Dimerization quality control ensures neuronal development and survival.	KLHL2 KEAP1 KLHL5 KLHL7 KLHL12	1.12e-08	24	109	5	30190310
Pubmed	CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.	PDHA1 RPS6KB2 FBXO11 RDH13 CLCNKB PTCD1 UNC45B STRADA TRIM16L SLC7A10 MOS MAP3K19	1.50e-08	440	109	12	35156780
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	USP30 SLC25A20 FAM185A SLC11A2 PDHA1 ADCK5 MCL1 RDH13 CPS1 SUCLA2 ME3 MICU3 PTCD1 HOGA1 ALAS1 TMEM223 TIMM22 PINK1	1.58e-08	1136	109	18	34800366
Pubmed	Novel CUL3 Variant Causing Familial Hyperkalemic Hypertension Impairs Regulation and Function of Ubiquitin Ligase Activity.	KEAP1 KLHL3 KLHL5 KLHL7 KLHL23 KLHL12	2.63e-08	57	109	6	34878901
Pubmed	hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure.	KLHL2 KEAP1 KLHL12	2.99e-08	3	109	3	15383316
Pubmed	A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.	KLHL2 IRS1 KEAP1 KLHL5 KLHL7 KLHL12	2.75e-07	84	109	6	34591642
Pubmed	A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.	KLHL2 IVNS1ABP KLHL5 KLHL7 KLHL23 KLHL12	3.39e-07	87	109	6	37495603
Pubmed	Human down syndrome cell adhesion molecules (DSCAMs) are functionally conserved with Drosophila Dscam[TM1] isoforms in controlling neurodevelopment.	DSCAM DSCAML1	9.73e-06	2	109	2	21645617
Pubmed	Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers.	GAD2 CDKL5	9.73e-06	2	109	2	30288694
Pubmed	Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance.	IRAK1 IRS1	9.73e-06	2	109	2	15849359
Pubmed	Gamabufotalin induces a negative feedback loop connecting ATP1A3 expression and the AQP4 pathway to promote temozolomide sensitivity in glioblastoma cells by targeting the amino acid Thr794.	AQP4 ATP1A3	9.73e-06	2	109	2	31746080
Pubmed	Regulation of anti-apoptotic Bcl-2 family protein Mcl-1 by S6 kinase 2.	RPS6KB2 MCL1	9.73e-06	2	109	2	28301598
Pubmed	DSCAM and DSCAML1 regulate the radial migration and callosal projection in developing cerebral cortex.	DSCAM DSCAML1	9.73e-06	2	109	2	25451118
Pubmed	Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?	DSCAM DSCAML1	9.73e-06	2	109	2	12051741
Pubmed	Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver.	SLC11A2 NDFIP2	9.73e-06	2	109	2	27048792
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	SLC25A20 PDHA1 ADCK5 RDH13 SUCLA2 ME3 MICU3 SLC16A1 HOGA1 ALAS1 TMEM223 TIMM22 PINK1	2.51e-05	1047	109	13	18614015
Pubmed	MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression.	IRS1 MAP3K1	2.91e-05	3	109	2	12458213
Pubmed	Mitochondrial ROS driven by NOX4 upregulation promotes hepatocellular carcinoma cell survival after incomplete radiofrequency ablation by inducing of mitophagy via Nrf2/PINK1.	NOX4 PINK1	2.91e-05	3	109	2	36964576
Pubmed	Monocarboxylate transporters in cancer.	HCAR1 SLC16A1	2.91e-05	3	109	2	31395464
Pubmed	Identification of an adaptor protein that facilitates Nrf2-Keap1 complex formation and modulates antioxidant response.	KEAP1 PAQR3	2.91e-05	3	109	2	27212020
Pubmed	Structural basis for dimerization quality control.	KEAP1 KLHL12	2.91e-05	3	109	2	32814905
Pubmed	Dual role of USP30 in controlling basal pexophagy and mitophagy.	USP30 PINK1	2.91e-05	3	109	2	29895712
Pubmed	Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations.	DSCAM DSCAML1	2.91e-05	3	109	2	27637097
Pubmed	The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction.	NOX4 IRS1	2.91e-05	3	109	2	14966267
Pubmed	Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance.	INPP1 IRS1	2.91e-05	3	109	2	14671192
Pubmed	Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments.	KEAP1 KLHDC1	2.91e-05	3	109	2	23722832
Pubmed	Hepatoprotective effects of Methyl ferulic acid on alcohol-induced liver oxidative injury in mice by inhibiting the NOX4/ROS-MAPK pathway.	NOX4 ROS1	2.91e-05	3	109	2	28890346
Pubmed	The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.	USP30 PINK1	2.91e-05	3	109	2	24896179
Pubmed	USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.	USP30 PINK1	2.91e-05	3	109	2	32636217
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	SLC25A20 ADCK5 RDH13 CPS1 SUCLA2 ME3 SLC16A1 HOGA1 ALAS1 TMEM223 TIMM22 PINK1	3.48e-05	926	109	12	20877624
Pubmed	Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals.	IRAK1 ROS1	5.82e-05	4	109	2	18566305
Pubmed	Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.	KEAP1 ADH5	5.82e-05	4	109	2	25777368
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	TTYH1 MCL1 MAP3K1 OPRL1 GGT7 SLC16A1 SELENOF RXFP4 ALAS1 HERC2	7.04e-05	697	109	10	28298427
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	SUCLA2 GGT7 KLHL5 KLHL12 HDAC10 ATP1A3 TM4SF1	7.26e-05	322	109	7	26514267
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	AREL1 HERC2 HERC6	7.39e-05	26	109	3	26949039
Pubmed	PINK1 positively regulates IL-1β-mediated signaling through Tollip and IRAK1 modulation.	IRAK1 PINK1	9.67e-05	5	109	2	23244239
Pubmed	Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.	SLC11A2 NDFIP2	9.67e-05	5	109	2	18776082
Pubmed	Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.	KLHL2 KLHL3	9.67e-05	5	109	2	24641320
Pubmed	Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells.	NOX4 KEAP1	9.67e-05	5	109	2	31491600
Pubmed	Repression of MAP3K1 expression and JNK activity by canonical Wnt signaling.	MAP3K1 AXIN2	9.67e-05	5	109	2	29787744
Pubmed	Bcl-2 family proteins participate in mitochondrial quality control by regulating Parkin/PINK1-dependent mitophagy.	MCL1 PINK1	9.67e-05	5	109	2	24999239
Pubmed	Mechanism and regulation of the Lys6-selective deubiquitinase USP30.	USP30 PINK1	9.67e-05	5	109	2	28945249
Pubmed	ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.	IRAK1 MAP3K1	1.45e-04	6	109	2	10465784
Pubmed	Evidence of efficient stop codon readthrough in four mammalian genes.	AQP4 OPRL1	1.45e-04	6	109	2	25013167
Pubmed	Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.	KEAP1 PINK1	1.45e-04	6	109	2	30907226
Pubmed	Quantitative trait locus that determines the cross-sectional shape of the femur in SAMP6 and SAMP2 mice.	AXIN2 CACNG4	1.45e-04	6	109	2	17295603
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	EPPK1 PDHA1 CPS1 FAM120A SLC16A1 ATP1A3	1.61e-04	256	109	6	35777956
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TTYH1 GAD2 DSCAM FBXO11 ZNFX1 DSCAML1 ADAM22 ME3 CNOT8 FAM120A KLHL7 HERC2 PINK1	1.97e-04	1285	109	13	35914814
Pubmed	ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3.	KLHL2 IRAK1	2.02e-04	7	109	2	19481056
Pubmed	Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.	NOX4 CPS1	2.02e-04	7	109	2	20031578
Pubmed	Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.	IRAK1 MAP3K1	2.69e-04	8	109	2	10346818
Pubmed	Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.	GAD2 ATP1A3	2.69e-04	8	109	2	23652595
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	KLHL2 KLHL3	2.69e-04	8	109	2	23838290
Pubmed	MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.	USP30 NDFIP2 AREL1	2.72e-04	40	109	3	30759391
Pubmed	MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.	MAP3K1 AXIN2	3.45e-04	9	109	2	20128690
Pubmed	Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs.	AQP4 OPRL1	3.45e-04	9	109	2	11726686
Pubmed	Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data.	GAD2 CPS1	4.31e-04	10	109	2	20659789
Pubmed	The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.	RPS6KB2 IRS1	4.31e-04	10	109	2	15249583
Pubmed	Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration.	DSCAM DSCAML1	4.31e-04	10	109	2	33585465
Pubmed	FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2.	RPS6KB2 MAP3K1	4.31e-04	10	109	2	16810323
Pubmed	A tumor-associated autoantibody panel for the detection of non-small cell lung cancer.	GAD2 TM4SF1	4.31e-04	10	109	2	36531074
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	DSCAM FNBP4 GEMIN5 SLC16A1 ATP1A3	4.51e-04	202	109	5	24639526
Pubmed	Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.	FBXO11 USH2A	5.26e-04	11	109	2	24349473
Pubmed	Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo.	NOX4 KEAP1	5.26e-04	11	109	2	21554947
Pubmed	Discovery and refinement of loci associated with lipid levels.	IRS1 CPS1 MAP3K1 ADH5 LIPG	5.49e-04	211	109	5	24097068
Pubmed	Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.	KLHL2 FBXO11 KLHL7 KLHL12	5.67e-04	120	109	4	27565346
Pubmed	USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice.	KEAP1 KLHL12	6.29e-04	12	109	2	37339955
Pubmed	The glucose-lactic acid cycle and gluconeogenesis.	PDHA1 SLC16A1	6.29e-04	12	109	2	7273846
Pubmed	KEAP1 Mutations Drive Tumorigenesis by Suppressing SOX9 Ubiquitination and Degradation.	KEAP1 KLHL3	6.29e-04	12	109	2	33173725
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	USP30 SLC11A2 HCAR1 ADAM22 TIMM22 PINK1	6.32e-04	331	109	6	19490893
Pubmed	Fatty Acid Binding Protein 3 Is Involved in n-3 and n-6 PUFA transport in mouse trophoblasts.	SLC16A1 SLC27A1	7.42e-04	13	109	2	25122651
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	KLHL2 ADCK5 MCL1 KEAP1 KLHL7 TMEM223 HERC2	8.21e-04	481	109	7	28190767
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	KLHL2 KEAP1 CNOT8 KLHL3 ALAS1 KLHL12 HSD17B14	8.41e-04	483	109	7	27107014
Pubmed	DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.	DSCAM DSCAML1	8.64e-04	14	109	2	19945391
Pubmed	Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors.	CPS1 GGT7	8.64e-04	14	109	2	16103213
Pubmed	DSCAM promotes axon fasciculation and growth in the developing optic pathway.	DSCAM DSCAML1	8.64e-04	14	109	2	28137836
Pubmed	The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.	LAMA2 ROS1	8.64e-04	14	109	2	9151674
Pubmed	Transcriptional map of chromosome region 6q16-->q21.	LAMA2 ROS1	8.64e-04	14	109	2	10575223
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	GAD2 PDHA1 ZNFX1 SUCLA2 AQP4 ADAM22 GGT7 CDKL5 MICU3 PLPPR4 SLC16A1	9.12e-04	1139	109	11	36417873
Pubmed	LC-MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line.	SLC16A1 ABCC10	9.95e-04	15	109	2	28112518
Pubmed	Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function.	GEMIN5 CNOT8	9.95e-04	15	109	2	31366290
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	KEAP1 CPS1 GGT7 FAM120A PTCD1 KLHL12	1.03e-03	364	109	6	24778252
Pubmed	Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling.	MCL1 KLHDC8A	1.13e-03	16	109	2	19004856
Pubmed	The goya mouse mutant reveals distinct newly identified roles for MAP3K1 in the development and survival of cochlear sensory hair cells.	MAP3K1 AXIN2	1.28e-03	17	109	2	26542706
Pubmed	Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.	IRS1 MAP3K1	1.28e-03	17	109	2	23754948
Pubmed	Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.	KEAP1 AXIN2	1.28e-03	17	109	2	17510365
Pubmed	Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.	SLC12A9 CPSF3	1.28e-03	17	109	2	11060040
Pubmed	AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.	SLC25A20 STRADA	1.44e-03	18	109	2	16054041
Pubmed	RNG105 deficiency impairs the dendritic localization of mRNAs for Na+/K+ ATPase subunit isoforms and leads to the degeneration of neuronal networks.	GAD2 ATP1A3	1.61e-03	19	109	2	20861386
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	MCL1 FBXO11 CNOT8 SLC16A1 PRRC2B	1.67e-03	271	109	5	25737280
Pubmed	Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.	SSTR5 OPRL1 RXFP4	1.72e-03	75	109	3	2834384
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PDHA1 GEMIN5 ZNFX1 SUCLA2 AQP4 ADAM22 CDKL5 FAM120A PLPPR4 SLC27A1 ATP1A3 PRRC2B	1.78e-03	1431	109	12	37142655
Pubmed	Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.	NOX4 CPS1	1.78e-03	20	109	2	23824729
Pubmed	Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria.	ALAS1 TIMM22	1.78e-03	20	109	2	28712724
Pubmed	Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.	NDFIP2 DSCAML1 KLHL3	1.78e-03	76	109	3	10574461
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	ADCK5 CYB561D2 IRS1 AREL1 PRRC2B PINK1	1.89e-03	410	109	6	25814554
Pubmed	Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.	ADCK5 RDH13 CPS1 SUCLA2 SLC16A1 HOGA1	1.96e-03	413	109	6	27499296
Pubmed	The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.	CPS1 AXIN2	1.97e-03	21	109	2	27088858
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	USP30 CLGN ARSA SELENOF CPSF3	1.99e-03	282	109	5	35007762
Interaction	KLHL17 interactions	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL7 KLHL23 KLHL12	4.36e-10	34	106	7	int:KLHL17
Interaction	KLHDC8A interactions	IVNS1ABP KLHL7 KLHDC8A KLHL23	5.93e-06	23	106	4	int:KLHDC8A
Interaction	ASTN1 interactions	DSCAM KEAP1 CDKL5	1.16e-05	9	106	3	int:ASTN1
GeneFamily	Kelch like\|BTB domain containing	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL7 KLHL23 KLHL12 KLHL33	6.86e-14	42	73	9	617
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	KLHL2 KEAP1 IVNS1ABP KLHL3 KLHL5 KLHL7 KLHL23 KLHL12	6.62e-08	134	73	8	861
GeneFamily	Solute carriers	SLC25A20 SLC11A2 SLC38A9 SLC47A2 SLC22A12 SLC12A9 SLC16A1 SLC27A1 SLC7A10	2.92e-05	395	73	9	752
Disease	age-related macular degeneration, cataract, glaucoma	ME3 HERC2	7.78e-05	4	107	2	EFO_0001365, MONDO_0005041, MONDO_0005129
Disease	X-03094 measurement	LIPG ATG4C	1.29e-04	5	107	2	EFO_0021188
Disease	Dystonia	SUCLA2 ARSA ATP1A3 PINK1	2.76e-04	86	107	4	C0013421
Disease	Adenocarcinoma of lung (disorder)	IRAK1 KEAP1 AQP4 ROS1 MOS	9.44e-04	206	107	5	C0152013
Disease	gallbladder cancer (is_implicated_in)	KEAP1 AXIN2	9.90e-04	13	107	2	DOID:3121 (is_implicated_in)
Disease	metabolite measurement	DSCAM CPS1 ADAM22 SLC22A12 ARSA HOGA1 HDAC10 HSD17B14	1.01e-03	560	107	8	EFO_0004725
Disease	eye colour measurement	MBTPS1 HAVCR2 ARNT2 HERC2 USH2A	1.21e-03	218	107	5	EFO_0009764
Disease	Down syndrome (implicated_via_orthology)	DSCAM DSCAML1	1.33e-03	15	107	2	DOID:14250 (implicated_via_orthology)
Disease	diabetes mellitus (biomarker_via_orthology)	AQP4 SLC22A12	2.14e-03	19	107	2	DOID:9351 (biomarker_via_orthology)
Disease	renovascular hypertension (biomarker_via_orthology)	LAMA2 CMA1	2.14e-03	19	107	2	DOID:1591 (biomarker_via_orthology)
Disease	level of Phosphatidylcholine (16:0_18:2) in blood serum	LIPG ATG4C	2.37e-03	20	107	2	OBA_2045071
Disease	glaucoma	ME3 AREL1 KLHL5 HERC2	2.43e-03	154	107	4	MONDO_0005041
Disease	Parkinson's disease (implicated_via_orthology)	SSTR5 AXIN2 OPRL1 PINK1	2.60e-03	157	107	4	DOID:14330 (implicated_via_orthology)
Disease	level of Phosphatidylinositol (18:0_20:4) in blood serum	LIPG ATG4C	3.14e-03	23	107	2	OBA_2045158
Disease	QT interval	SLC25A20 SUCLA2 GGT7 AREL1 SLC16A1 ROS1 PRRC2B	3.36e-03	534	107	7	EFO_0004682

Protein segments in the cluster

Peptide	Gene	Start	Entry
VALLAGCTGIGIGFY	TTYH1	96	Q9H313
AQCLGAIIGAGILYL	AQP4	121	P55087
GVIIAGYCVEGTLAK	CPSF3	351	Q9UKF6
LGGGVTALGSLCYAE	SLC7A10	81	Q9NS82
LLGCGISTGYGAAVN	ADH5	171	P11766
KGLDIYLIIGICGGG	CD2	206	P06729
GAAYIGGICSLLKGG	ADAM22	341	Q9P0K1
SNGGLGSLKVVCGYL	AXIN2	211	Q9Y2T1
NGGLYVKLGQGLCSF	ADCK5	141	Q3MIX3
KGILSLEYCVGIIGG	ATG4C	311	Q96DT6
ADVGQGSKYCLVAIG	ARNT2	301	Q9HBZ2
AGISIGILGCYVSGV	PAQR3	146	Q6TCH7
QLYVCIGVIGGLGLA	SLC16A1	111	P53985
YALGLAGGAVLGAVL	ABCC10	326	Q5T3U5
FTGGIGNKLCALLYG	GAD2	36	Q05329
GAAGAGYKSLCVVQG	INPP1	286	P49441
ILEGQLYVSGGCGGT	KLHL33	366	A6NCF5
YALGAVGGVCALANV	HOGA1	231	Q86XE5
EGGGRIVLYGDSNCL	MBTPS1	836	Q14703
AGVCALNGKLYIVGG	IVNS1ABP	456	Q9Y6Y0
AVCELGGYLYIIGGA	IVNS1ABP	506	Q9Y6Y0
GAGVAVLNGKLFVCG	IVNS1ABP	551	Q9Y6Y0
GTLGKAFGCVGGYIA	ALAS1	441	P13196
GKVYACGEATNGRLG	HERC2	3011	O95714
KGGKVICLGTVYGNI	FAM185A	196	Q8N0U4
YLIGQSIGKGCSAAV	PINK1	156	Q9BXM7
AEGLCGTYLALGANG	GGT7	551	Q9UJ14
VGCAIQLYFVLALGG	OR2W6P	101	Q8NHA6
CIFLGTVLGGVYILG	PEX3	16	P56589
GFGVCFLLLVGGSVA	GPR153	171	Q6NV75
GALKNLGVVYISCGD	HERC6	231	Q8IVU3
GCGLNDVLGSIAYGT	LIPG	251	Q9Y5X9
LKNLLAGGFGGVCLV	SLC25A20	11	O43772
TLAVDIYKGGVVLGC	SLC11A2	351	P49281
LNIRGKYIGGGVCIN	LAMA2	366	P24043
VEANGLIYVCGGSLG	KLHL7	426	Q8IXQ5
AAAGGGLVGLVCYQL	MICU3	71	Q86XE3
GLLRCGKGTTYEGGV	ARSA	296	P15289
GYLAALAKACFGGNI	FAM120A	76	Q9NZB2
YGVDLIEVSGNGCGV	PMS2P1	261	A4D2B8
LKIGEGGFGCVYRAV	IRAK1	216	P51617
LCGAAGGLENGLNYI	IRS1	1166	P35568
VGVAVLSGKLYAVGG	KLHL5	601	Q96PQ7
VGVCLLGDKLYAVGG	KLHL5	701	Q96PQ7
LNYEVSLCVAGGIGV	NOX4	421	Q9NPH5
GAAVLLKDYVTGGAC	RDH13	16	Q8NBN7
CTGLVAGSYIGGFLN	OR9G4	156	Q8NGQ1
NTIAGRYGAICGFGL	NDFIP2	256	Q9NV92
IRSAYALGGLGSGIC	CPS1	586	P31327
VLAGGRVCAVLEGGY	HDAC10	291	Q969S8
GVIYCLGGYDGLNIL	KLHL12	426	Q53G59
TLGGCVYALGGYRKG	KLHL23	366	Q8NBE8
GGLCIGAGRIYSRKN	CACNG4	121	Q9UBN1
NGGILVYNSGLGCIE	FBXO11	686	Q86XK2
GIYGKAGVLNCSVDG	DSCAML1	701	Q8TD84
GRLVGKCLYESSLGG	AREL1	556	O15033
VGKLALYTACGGVNP	ME3	206	Q16798
IGAILCFLAYGIQAG	ATP1A3	96	P13637
IELLVTGGAELGYGC	HSD17B14	241	Q9BPX1
AGCVVGGLLYAVGGR	KEAP1	366	Q14145
LLETGGQVYAIGGCD	KLHDC8A	26	Q8IYD2
TCAVLGNKGYIFGGR	KLHDC1	201	Q8N7A1
GVCAVNGLLYVVGGD	KLHL3	531	Q9UH77
FVLGALGNGVALCGF	HCAR1	26	Q9BXC0
CGRLYGLGTGVAQKQ	CNOT8	256	Q9UFF9
GIGVSRTEIGKYCGL	DCBLD2	136	Q96PD2
LGVVGEGAYGVVLKC	CDKL5	16	O76039
GLGGVGAAFTCITIY	SLC22A12	441	Q96S37
NIGGIIRYSGAACGL	SLC38A9	501	Q8NBW4
AGLQCSGGVGLLYPK	CYB561D2	131	O14569
ILGKGAYGTVYCGLT	MAP3K19	1066	Q56UN5
RNAVIGLNLYCGGAG	MCL1	6	Q07820
DDICIYGGLGLGGLL	LST1	6	O00453
CLLQRLGAGGFGSVY	MOS	61	P00540
GLYLAVCVGGLLGNC	OPRL1	56	P41146
AGSIGIGGVDYVLNC	MAP3K1	726	Q13233
GIYGKAVILNCSAEG	DSCAM	701	O60469
YGLVGAIGLLGNLAV	RXFP4	46	Q8TDU9
GNKYLIKLGACTGGG	USH2A	2211	O75445
VTIVACSGGNGYLGG	USH2A	2791	O75445
GGCYELLTVIGKGFE	STRADA	66	Q7RTN6
EAICCVYGGVLRGTG	SLC47A2	421	Q86VL8
VKATGGLCLLGAYAD	FNBP4	101	Q8N3X1
GGKLYLILECLSGGE	RPS6KB2	141	Q9UBS0
GLRFLGDYQCGGAII	OVCH1	591	Q7RTY7
GATIRIGIYIGAGIC	HAVCR2	196	Q8TDQ0
IGIYIGAGICAGLAL	HAVCR2	201	Q8TDQ0
IYGGLVLIVSGVVGC	MT-ND6	26	P03923
GVRRYLCGLGAVGGV	EPPK1	921	P58107
AVLGALCVYGAGHLE	TRGV9	11	Q99603
CAAGLGGNTLVIYVV	SSTR5	51	P35346
YIGLDGNIGCLVNGA	SUCLA2	311	Q9P2R7
PLLCAGVAQGIVSYG	CMA1	206	P23946
QDGIDCGGAYIKLLA	CLGN	146	O14967
GITCIYKSDLLGAGG	CHSY3	781	Q70JA7
VALGGLCGILGSAYL	CLCNKB	286	P51801
VDVYCGFLIGGGIAL	PLPPR4	306	Q7Z2D5
LCKLGSAGGTDYGLR	UNC45B	486	Q8IWX7
YGLAVGCGAIGALVL	TMEM223	96	A0PJW6
VPLGAGIALACKYNG	PDHA1	171	P08559
GNIIGVGQCLIYGLT	SLC27A1	296	Q6PCB7
YAGAILEVCGUKLGR	SELENOF	86	O60613
GLVGGVCTLGAGLYA	SLC12A9	176	Q9BXP2
LALYSCGGEGIVLQH	GEMIN5	496	Q8TEQ6
SGLCGGGVLGARSIY	PRRC2B	1086	Q5JSZ5
GLAAGVGLANACYAI	ROS1	1911	P08922
AALIGIAGSGYCVIV	TM4SF1	96	P30408
IAGSGYCVIVAALGL	TM4SF1	101	P30408
CGHVEGLLYGGLLVK	ZNFX1	1416	Q9P2E3
FKAALACVGGFVLGG	TIMM22	71	Q9Y584
IGFRAGLKAGAIGCG	TIMM22	166	Q9Y584
GVIGGIAAALAAGIY	USP30	36	Q70CQ3
YTVLIGGCGRVGYLK	PTCD1	176	O75127
ADIGCGYGGLLVELS	METTL1	81	Q9UBP6
RGKGAEGLGTYCGLR	TTC31	96	Q49AM3
GAGTYVGLTCKGIDQ	TRIM16L	221	Q309B1
AGVCAVNGLLYVVGG	KLHL2	536	O95198
VNGLLYVVGGDDGSC	KLHL2	541	O95198