Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium:bicarbonate symporter activity	SLC4A4 SLC4A9	4.99e-05	6	37	2	GO:0008510
GeneOntologyMolecularFunction	alkaline phosphatase activity	ALPL ALPP	4.99e-05	6	37	2	GO:0004035
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPM1 SLC4A4 KCNIP2 TRPM3 SLC4A9 TRPM2	1.95e-04	465	37	6	GO:0046873
GeneOntologyMolecularFunction	monoatomic cation:bicarbonate symporter activity	SLC4A4 SLC4A9	2.57e-04	13	37	2	GO:0140410
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	TRPM1 SLC4A4 KCNIP2 TRPM3 SLC4A9 TRPM2	9.49e-04	627	37	6	GO:0022890
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	TRPM1 SLC4A4 KCNIP2 TRPM3 SLC4A9 TRPM2	1.28e-03	664	37	6	GO:0008324
GeneOntologyMolecularFunction	mRNA 3'-UTR AU-rich region binding	CPSF1 RBMS3	1.31e-03	29	37	2	GO:0035925
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC4A4 SLC4A9	1.60e-03	32	37	2	GO:0015106
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC4A4 SLC4A9	1.60e-03	32	37	2	GO:0005452
GeneOntologyMolecularFunction	calcium channel activity	TRPM1 TRPM3 TRPM2	1.74e-03	129	37	3	GO:0005262
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-7 ERVK-24	2.14e-03	37	37	2	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-7 ERVK-24	2.25e-03	38	37	2	GO:0070001
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	TRPM1 SLC4A4 KCNIP2 TRPM3 SLC4A9 TRPM2	2.49e-03	758	37	6	GO:0015318
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPM1 TRPM3 TRPM2	2.73e-03	151	37	3	GO:0015085
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	TRPM1 SLC4A4 KCNIP2 TRPM3 SLC4A9 TRPM2	3.12e-03	793	37	6	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPM1 KCNIP2 TRPM3 TRPM2	3.61e-03	343	37	4	GO:0005261
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC4A4 SLC4A9 TRPM2	3.87e-03	171	37	3	GO:0015081
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-7 MMP1 ERVK-24 ECE1	7.99e-03	430	37	4	GO:0004175
MousePheno	decreased incidence of tumors by chemical induction	AHRR MMP1 PTGS2 MPG	1.97e-05	88	26	4	MP:0004502
MousePheno	decreased incidence of induced tumors	AHRR MMP1 PTGS2 MPG	3.81e-05	104	26	4	MP:0002053
MousePheno	decreased tumor incidence	AHRR MMP1 PTGS2 MPG	9.11e-05	130	26	4	MP:0002052
Domain	TRPM_tetra	TRPM1 TRPM3	2.04e-05	4	35	2	PF16519
Domain	alkPPc	ALPL ALPP	2.04e-05	4	35	2	SM00098
Domain	Alk_phosphatase	ALPL ALPP	2.04e-05	4	35	2	PF00245
Domain	Alkaline_phosphatase_AS	ALPL ALPP	2.04e-05	4	35	2	IPR018299
Domain	ALKALINE_PHOSPHATASE	ALPL ALPP	2.04e-05	4	35	2	PS00123
Domain	Alkaline_phosphatase	ALPL ALPP	2.04e-05	4	35	2	IPR001952
Domain	TRPM_tetra	TRPM1 TRPM3	2.04e-05	4	35	2	IPR032415
Domain	Na/HCO3_transpt	SLC4A4 SLC4A9	3.40e-05	5	35	2	IPR003024
Domain	Band3_cytoplasmic_dom	SLC4A4 SLC4A9	1.22e-04	9	35	2	IPR013769
Domain	Band_3_cyto	SLC4A4 SLC4A9	1.22e-04	9	35	2	PF07565
Domain	-	SLC4A4 SLC4A9	1.22e-04	9	35	2	3.40.1100.10
Domain	PTrfase/Anion_transptr	SLC4A4 SLC4A9	1.52e-04	10	35	2	IPR016152
Domain	HCO3_cotransp	SLC4A4 SLC4A9	1.52e-04	10	35	2	PF00955
Domain	HCO3_transpt_euk	SLC4A4 SLC4A9	1.52e-04	10	35	2	IPR003020
Domain	HCO3_transpt_C	SLC4A4 SLC4A9	1.52e-04	10	35	2	IPR011531
Domain	Ion_trans_dom	TRPM1 TRPM3 TRPM2	1.26e-03	114	35	3	IPR005821
Domain	Ion_trans	TRPM1 TRPM3 TRPM2	1.26e-03	114	35	3	PF00520
Domain	Alkaline_phosphatase_core	ALPL ALPP	1.53e-03	31	35	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ALPL ALPP	1.53e-03	31	35	2	IPR017849
Domain	-	ALPL ALPP	1.53e-03	31	35	2	3.40.720.10
Domain	fn3	FSD2 MERTK PTPRD	3.42e-03	162	35	3	PF00041
Domain	FN3	FSD2 MERTK PTPRD	4.96e-03	185	35	3	SM00060
Domain	FN3	FSD2 MERTK PTPRD	6.07e-03	199	35	3	PS50853
Domain	FN3_dom	FSD2 MERTK PTPRD	6.95e-03	209	35	3	IPR003961
Domain	MetalloPept_cat_dom	MMP1 ECE1	1.01e-02	81	35	2	IPR024079
Domain	-	MMP1 ECE1	1.01e-02	81	35	2	3.40.390.10
Domain	TyrKc	BLK MERTK	1.18e-02	88	35	2	SM00219
Domain	Tyr_kinase_cat_dom	BLK MERTK	1.18e-02	88	35	2	IPR020635
Domain	PROTEIN_KINASE_TYR	BLK MERTK	1.42e-02	97	35	2	PS00109
Domain	Tyr_kinase_AS	BLK MERTK	1.42e-02	97	35	2	IPR008266
Domain	ZINC_PROTEASE	MMP1 ECE1	1.45e-02	98	35	2	PS00142
Pathway	REACTOME_TRP_CHANNELS	TRPM1 TRPM3 TRPM2	3.04e-05	28	31	3	MM14943
Pathway	REACTOME_TRP_CHANNELS	TRPM1 TRPM3 TRPM2	3.04e-05	28	31	3	M27241
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A4 SLC4A9	2.08e-04	10	31	2	M27335
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A4 SLC4A9	2.08e-04	10	31	2	MM15073
Pathway	KEGG_FOLATE_BIOSYNTHESIS	ALPL ALPP	2.54e-04	11	31	2	M2220
Pathway	WP_QUERCETIN_AND_NFKB_AP1_INDUCED_APOPTOSIS	MMP1 PTGS2	5.51e-04	16	31	2	M42567
Pubmed	Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.	TRPM1 TRPM3 TRPM2	2.42e-07	12	37	3	19850157
Pubmed	Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.	TRPM1 TRPM3	1.10e-06	2	37	2	21278253
Pubmed	In with the TRP channels: intracellular functions for TRPM1 and TRPM2.	TRPM1 TRPM2	1.10e-06	2	37	2	19887679
Pubmed	Modifications in a flexible surface loop modulate the isozyme-specific properties of mammalian alkaline phosphatases.	ALPL ALPP	1.10e-06	2	37	2	8244974
Pubmed	Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism.	MMP1 PTGS2	1.10e-06	2	37	2	16076963
Pubmed	Mammalian alkaline phosphatase catalysis requires active site structure stabilization via the N-terminal amino acid microenvironment.	ALPL ALPP	1.10e-06	2	37	2	16893177
Pubmed	Immunohistochemical Expression of Matrix Metalloproteinase-1 and Cyclooxygenase-2 in Cutaneous Squamous Cell and Basal Cell Carcinoma.	MMP1 PTGS2	1.10e-06	2	37	2	34477058
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPM1 TRPM3 TRPM2	2.21e-06	24	37	3	33884443
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPM1 TRPM3 TRPM2	2.51e-06	25	37	3	16382100
Pubmed	An introduction to TRP channels.	TRPM1 TRPM3 TRPM2	3.19e-06	27	37	3	16460286
Pubmed	The defect seen in the phosphatidylinositol hydrolysis pathway in HIV-infected lymphocytes and lymphoblastoid cells is due to inhibition of the inositol 1,4,5-trisphosphate 1,3,4,5-tetrakisphosphate 5-phosphomonoesterase.	ALPL ALPP	3.30e-06	3	37	2	1321014
Pubmed	Particulate matter induces pro-inflammatory cytokines via phosphorylation of p38 MAPK possibly leading to dermal inflammaging.	MMP1 PTGS2	3.30e-06	3	37	2	31001893
Pubmed	Matrix metalloproteinase (MMP)-1 and MMP-2, but not COX-2 serve as additional predictors for chronic venous ulcer healing.	MMP1 PTGS2	3.30e-06	3	37	2	33768649
Pubmed	MMP1, MMP9, and COX2 expressions in promonocytes are induced by breast cancer cells and correlate with collagen degradation, transformation-like morphological changes in MCF-10A acini, and tumor aggressiveness.	MMP1 PTGS2	3.30e-06	3	37	2	23762835
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPM1 TRPM3 TRPM2	5.92e-06	33	37	3	19834762
Pubmed	Differential expression of matrix metalloproteinases and cyclooxygenases in synovial cells exposed to Borrelia burgdorferi.	MMP1 PTGS2	6.60e-06	4	37	2	15654517
Pubmed	Structural evidence of functional divergence in human alkaline phosphatases.	ALPL ALPP	6.60e-06	4	37	2	12372831
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-7 ERVK-24	6.60e-06	4	37	2	10469592
Pubmed	Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.	TRPM1 TRPM3	6.60e-06	4	37	2	22211741
Pubmed	IGF-1 and IGF-binding proteins and bone mass, geometry, and strength: relation to metabolic control in adolescent girls with type 1 diabetes.	IGFBP5 ALPL	6.60e-06	4	37	2	18665784
Pubmed	Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis.	MMP1 PTGS2	6.60e-06	4	37	2	21481333
Pubmed	Stage-specific expression patterns of alkaline phosphatase during development of the first arch skeleton in inbred C57BL/6 mouse embryos.	ALPL ALPP	6.60e-06	4	37	2	9061447
Pubmed	Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.	MMP1 PTGS2	6.60e-06	4	37	2	17429393
Pubmed	Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.	ALPL ALPP	6.60e-06	4	37	2	9056646
Pubmed	The Sensory Coding of Warm Perception.	TRPM3 TRPM2	1.10e-05	5	37	2	32208171
Pubmed	Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte.	TRPM1 TRPM2	1.10e-05	5	37	2	16857711
Pubmed	Central role of pyrophosphate in acellular cementum formation.	ALPL ALPP	1.10e-05	5	37	2	22675556
Pubmed	Two alkaline phosphatase genes are expressed during early development in the mouse embryo.	ALPL ALPP	1.10e-05	5	37	2	2133555
Pubmed	Germ cell nuclear antigen (GCNA1) expression does not require a gonadal environment or steroidogenic factor 1: examination of GCNA1 in ectopic germ cells and in Ftz-F1 null mice.	ALPL ALPP	1.10e-05	5	37	2	9291464
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPM1 TRPM3 TRPM2	1.42e-05	44	37	3	19322198
Pubmed	Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population.	MMP1 PTGS2	1.65e-05	6	37	2	22819245
Pubmed	Dissection of the odontoblast differentiation process in vitro by a combination of FGF1, FGF2, and TGFbeta1.	ALPL ALPP	1.65e-05	6	37	2	10878613
Pubmed	A synaptic temperature sensor for body cooling.	TRPM3 TRPM2	1.65e-05	6	37	2	34672983
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	PTPRD SLC4A4 IGFBP5 ECE1 RBMS3	1.77e-05	306	37	5	18973680
Pubmed	TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.	ALPL ALPP	7.22e-05	12	37	2	31289197
Pubmed	MicroRNA profile of the developing mouse retina.	TRPM1 TRPM3	9.94e-05	14	37	2	19933188
Pubmed	Analysis of common germline polymorphisms as prognostic factors in patients with lymph node-positive breast cancer.	MMP1 PTGS2	9.94e-05	14	37	2	20204402
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	BLK SEPHS2 MMP1 ARID1A ECE1 TRPM3	1.12e-04	730	37	6	34857952
Pubmed	Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin.	MERTK PTGS2	1.15e-04	15	37	2	34721382
Pubmed	Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs.	MMP1 PTGS2	1.15e-04	15	37	2	20538124
Pubmed	Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.	PTPRD RAPGEF4	1.48e-04	17	37	2	20200953
Pubmed	Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia.	TRPM3 TRPM2	1.67e-04	18	37	2	31911949
Pubmed	Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.	PTGS2 ALPL	2.99e-04	24	37	2	29174564
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	FLNB FRY MERTK PTPRD ARID1A ALPL RAPGEF4	3.60e-04	1285	37	7	35914814
Pubmed	Forkhead box a2 (FOXA2) is essential for uterine function and fertility.	PTGS2 ALPL	5.69e-04	33	37	2	28049832
Pubmed	Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling.	IGFBP5 PTGS2	6.05e-04	34	37	2	35194044
Pubmed	PTEN identified as important risk factor of chronic obstructive pulmonary disease.	AHRR MMP1 IGFBP5 PTGS2	6.57e-04	374	37	4	19625176
Pubmed	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	AHRR MMP1 IGFBP5 PTGS2	7.04e-04	381	37	4	18676680
Pubmed	Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.	AHRR MMP1 IGFBP5 PTGS2	7.11e-04	382	37	4	19170196
Pubmed	Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".	MMP1 IGFBP5 PTGS2	8.16e-04	172	37	3	20628624
Pubmed	Mouse model resources for vision research.	TRPM1 MERTK	8.80e-04	41	37	2	21052544
Pubmed	Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment.	IGFBP5 ALPL	1.01e-03	44	37	2	21308778
GeneFamily	Transient receptor potential cation channels	TRPM1 TRPM3 TRPM2	5.77e-06	28	23	3	249
GeneFamily	Alkaline phosphatases	ALPL ALPP	9.27e-06	4	23	2	1072
GeneFamily	Fibronectin type III domain containing	FSD2 MERTK PTPRD	1.06e-03	160	23	3	555
CoexpressionAtlas	kidney_adult_JuxtaGlom_Ren1_Captopr_top-relative-expression-ranked_1000	SEPHS2 FRY SLC4A4 IGFBP5 RETSAT SLC4A9 ALPL RAPGEF4	3.06e-05	778	35	8	gudmap_kidney_adult_JuxtaGlom_Ren1_Captopr_1000
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	FLNB ECE1 TRPM3 RBMS3 RAPGEF4	3.64e-07	189	35	5	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Vein\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FLNB FRY IGFBP5 ECE1 RAPGEF4	4.81e-07	200	35	5	7eb366b2c5394af7c77650bde6261e7dac67154e
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRD SLC4A4 RETSAT RAPGEF4	6.70e-06	156	35	4	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRY TRPM3 RBMS3 RAPGEF4	7.59e-06	161	35	4	1b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB IGFBP5 ECE1 SLC4A9	8.97e-06	168	35	4	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB IGFBP5 ECE1 SLC4A9	8.97e-06	168	35	4	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNB SLC4A4 IGFBP5 STK32B	1.18e-05	180	35	4	c4068fe47408cfd899131a85fa4b7e5908926f94
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTPRD SLC4A4 TRPM3 STK32B	1.18e-05	180	35	4	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	Endothelial-B-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	FLNB IGFBP5 ECE1 STK32B	1.31e-05	185	35	4	133c9dc64d564dae4aeeeca22f386aa3f13fa980
ToppCell	Mesenchymal_cells-Osteo-CAR\|World / Lineage and Cell class	PTPRD IGFBP5 RBMS3 ALPL	1.31e-05	185	35	4	16f1588893d09c864e0cb4f837a1b972a1a57baa
ToppCell	10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PTPRD IGFBP5 RBMS3 ALPL	1.40e-05	188	35	4	de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCell	LAM-Epithelial-AT1\|Epithelial / Condition, Lineage and Cell class	ECE1 RBMS3 PTGS2 ALPP	1.49e-05	191	35	4	3457e15d1e9b36a78363d46b320c4ec46b40290a
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	FLNB ECE1 TRPM3 RAPGEF4	1.52e-05	192	35	4	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	IPF-Epithelial-Club\|Epithelial / Disease state, Lineage and Cell class	PTPRD ECE1 RBMS3 ALPL	1.52e-05	192	35	4	356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	FLNB ECE1 RBMS3 ALPL	1.58e-05	194	35	4	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC4A4 IGFBP5 ECE1 TRPM3	1.58e-05	194	35	4	08fad7591c20568de797cf8e206de2d0b1d78aab
ToppCell	367C-Endothelial_cells\|367C / Donor, Lineage, Cell class and subclass (all cells)	FLNB FRY ECE1 RAPGEF4	1.75e-05	199	35	4	636ff80938907f137e955388797072ab45289062
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP5 ECE1 RBMS3 RAPGEF4	1.75e-05	199	35	4	8b62d43af8b2ebb4c1b2d068d50beaf35728dbe7
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP5 ECE1 RBMS3 RAPGEF4	1.75e-05	199	35	4	da5a88749d859d535daa030d0974485906cc0ba7
ToppCell	367C-Endothelial_cells-Endothelial-A_(Artery)\|367C / Donor, Lineage, Cell class and subclass (all cells)	FLNB FRY ECE1 RAPGEF4	1.75e-05	199	35	4	29ed081bd5204a32068b420f2244f3704891547b
ToppCell	367C-Endothelial_cells-Endothelial-A_(Artery)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	FLNB FRY ECE1 RAPGEF4	1.75e-05	199	35	4	c2d85f80037f209a4a329790f475d9f98f590262
ToppCell	Macroglial-Astrocytes-SLC14A1\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MERTK SLC4A4 TRPM3 RBMS3	1.78e-05	200	35	4	16f468217427921fa18c6d078ffa990eb019b257
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP5 ECE1 RBMS3 RAPGEF4	1.78e-05	200	35	4	2e47888e041ec3d265425d1df97b6665c6da889c
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / Treatment groups by lineage, cell group, cell type	FLNB IGFBP5 ECE1 RAPGEF4	1.78e-05	200	35	4	b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCell	Macroglial-Astrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MERTK SLC4A4 TRPM3 RBMS3	1.78e-05	200	35	4	941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCell	Macroglial-Astrocytes-SLC14A1---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MERTK SLC4A4 TRPM3 RBMS3	1.78e-05	200	35	4	d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCell	Macroglial-Astrocytes-SLC14A1----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MERTK SLC4A4 TRPM3 RBMS3	1.78e-05	200	35	4	f861509b54185d89931db64da1b9d81986cc7938
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP5 ECE1 RBMS3 RAPGEF4	1.78e-05	200	35	4	3007583eaad3a5ae2df010513d3e4df59155123d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Macroglial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	SLC4A4 KCNIP2 RETSAT ALPL	1.78e-05	200	35	4	3a954d9d542e52c9b181f0850a09b1bff0a0c82d
ToppCell	Macroglial-Astrocytes-SLC14A1--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MERTK SLC4A4 TRPM3 RBMS3	1.78e-05	200	35	4	0442894c39eec69850c090957a5dc7bcecd21e04
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP5 ECE1 RBMS3 RAPGEF4	1.78e-05	200	35	4	50fa0f8a3e490d5941b34e66a10158eba6c909d4
ToppCell	kidney_cells-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP5 ECE1 RBMS3 RAPGEF4	1.78e-05	200	35	4	9f1626a7e1bd00977a5c316cafbdf654b52bad94
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP5 ECE1 RBMS3 RAPGEF4	1.78e-05	200	35	4	7a69ad5b6c84f1aebacea5cacb9bc5c63dfd1dac
ToppCell	Macroglial-Astrocytes-SLC14A1-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	MERTK SLC4A4 TRPM3 RBMS3	1.78e-05	200	35	4	01819446deeab9054f5cfe889d53bb49d137dbc0
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	FLNB FRY MERTK ECE1	1.78e-05	200	35	4	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	Control_saline-Endothelial-Endothelial-Artery\|Control_saline / Treatment groups by lineage, cell group, cell type	FLNB MERTK ECE1 ALPL	1.78e-05	200	35	4	65b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP5 ECE1 RBMS3 RAPGEF4	1.78e-05	200	35	4	dba96cda5f3b780a3d4171b61bc8aaddc1f5d466
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IGFBP5 HAP1 STK32B	9.52e-05	113	35	3	feb3c6a7723263d58e5ce020a0097fedfcf78ca8
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FSD2 AHRR SLC4A9	1.06e-04	117	35	3	240cd636d1f5d3f270825ace02126fae993f5802
ToppCell	control-Myeloid-CD14_Monocytes_3\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	TRPM1 STK32B TRPM2	1.72e-04	138	35	3	683cae06f710061d7d74c2f75eb511a2af55bacf
ToppCell	control-Myeloid-CD14_Monocytes_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	TRPM1 P2RY11 STK32B	1.72e-04	138	35	3	74087d94f993b9efa4a6e1ee35451a27cf341c4b
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Akr1c18_Ntf3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	KCNIP2 RBMS3 SLC4A9	2.16e-04	149	35	3	1e77f03d2b32f366018fec3462d1b75f6e7febb9
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_D2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KCNIP2 RBMS3 P2RY11	2.20e-04	150	35	3	ecc4fc94958cf2378dd003966dccba81b3c00f8e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A4 KCNIP2 TRPM3	2.24e-04	151	35	3	f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCell	droplet-Lung-3m-Hematologic-myeloid-neutrophil-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SEPHS2 PTGS2 TRPM2	2.33e-04	153	35	3	ce6e462ce4dbaf9d265f1f9e2f791efbba8c1dd0
ToppCell	droplet-Lung-3m-Hematologic-myeloid-neutrophil\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SEPHS2 PTGS2 TRPM2	2.33e-04	153	35	3	9dba38574908f31a1194b8a339868f5e4be1be71
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-C_(Capillary_Aerocyte_)\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	FRY MMP1 KCNIP2	2.51e-04	157	35	3	84f629b7f589ca8a1abc220fa740c4a6fdc1b579
ToppCell	frontal_cortex-Non-neuronal-astrocyte\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MERTK SLC4A4 ALPL	2.51e-04	157	35	3	803af734d7f775d294391e2b84e472a732e18cef
ToppCell	droplet-Lung-nan-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPHS2 PTGS2 TRPM2	2.51e-04	157	35	3	3cffedafff31efb5b3259194157b54a768367459
ToppCell	droplet-Lung-nan-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPHS2 PTGS2 TRPM2	2.51e-04	157	35	3	f87e867a394b0453ebd92c592e80450caf5902cb
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IGFBP5 RBMS3 HAP1	2.51e-04	157	35	3	741d79c10cb87fa7f14080c6fccb1553c3a20bad
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MERTK SLC4A4 ALPL	2.51e-04	157	35	3	9aa5304a9704da6dd4eda7d6940494b00e38b2e8
ToppCell	frontal_cortex-Non-neuronal-astrocyte-Astro\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MERTK SLC4A4 ALPL	2.51e-04	157	35	3	0551442ae14685d8fe5729e3960c6324b1e05e4d
ToppCell	AT1-AT2_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ECE1 RBMS3 PTGS2	2.56e-04	158	35	3	3bc51cfd37b289cc3e866b54ce55a298e5eff690
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRD SLC4A4 RAPGEF4	2.66e-04	160	35	3	c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCell	AT1-AT2_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	ECE1 RBMS3 PTGS2	2.76e-04	162	35	3	57d627259d27f39885bf416d74bcb6656db6e27b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP5 ALPL RAPGEF4	2.81e-04	163	35	3	73c03e29a6d7a6863c5e9aa5e8b963ef691f1ddb
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GIT2 TRPM3 TRPM2	2.86e-04	164	35	3	b895674ed2df87db8fbfb30b7e31620945588491
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____proximal_tube_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPHS2 SLC4A4 RETSAT	2.91e-04	165	35	3	082f62f759a0b16ab56fad6dd4c4dd70b4f18a5c
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC4A4 KCNIP2 RBMS3	2.91e-04	165	35	3	d8df50f5a3b646e8ea13739fdc65ce6f39b4d4d2
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP5 ACSM6 SLC4A9	2.91e-04	165	35	3	a6c6de17fec678ad0cac3138dde3a14cc39ffd26
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Tac1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SLC4A4 KCNIP2 RBMS3	2.96e-04	166	35	3	59d47c1fca7a8c70f6998f3367a9dbcb9b67966f
ToppCell	COPD-Lymphoid-ILC_B\|Lymphoid / Disease state, Lineage and Cell class	FRY RBMS3 ALPP	2.96e-04	166	35	3	e2cad1db536d5ad5a34c337c19b5e7d1a2851552
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM1 IGFBP5 SLC4A9	3.01e-04	167	35	3	166b7b4ca0663cde6d88219ee0bcc1988d03dab8
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRD SLC4A4 TRPM3	3.07e-04	168	35	3	fa0d251693935116adf633d02b7ec4a295100865
ToppCell	facs-Marrow-KLS-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ECE1 HAP1 ANKRD53	3.12e-04	169	35	3	d6ad3b637de2935c656aad47ad82d6e8a8bd1227
ToppCell	facs-Marrow-KLS-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ECE1 HAP1 ANKRD53	3.12e-04	169	35	3	60ef186518d0dc63dbded2a77c65cfe3129df754
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FSD2 IGFBP5 RETSAT	3.17e-04	170	35	3	ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell	-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	BLK FLNB ANKRD53	3.17e-04	170	35	3	601630644f09133ee4c5e64499460b55cf3e80a0
ToppCell	CTRL-Myeloid-Neutrophil\|Myeloid / Disease state, Lineage and Cell class	ECE1 PTGS2 ALPL	3.17e-04	170	35	3	151dabe1d240dde414c881bf4fa816c69fa1c32d
ToppCell	droplet-Spleen-nan-3m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ECE1 HAP1 TRPM2	3.23e-04	171	35	3	5b74df72e36ad04dfb25c72f1ca8efe043f6cda6
ToppCell	droplet-Spleen-nan-18m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ECE1 PTGS2 TRPM2	3.23e-04	171	35	3	4a2e6ea9674bf23e8012ef0bb2bf19ce1f55fcd5
ToppCell	Control-Epithelial_cells-Airway_basal\|Control / group, cell type (main and fine annotations)	MMP1 SLC4A4 ECE1	3.23e-04	171	35	3	3965ced4be6db14265a90673502fceee425837ca
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	ECE1 RBMS3 HAP1	3.23e-04	171	35	3	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	AT1-AT2_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	ECE1 RBMS3 PTGS2	3.23e-04	171	35	3	0b9912f07393aca889db72b40da08e0bc9bc1e8c
ToppCell	droplet-Spleen-nan-18m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ECE1 PTGS2 TRPM2	3.28e-04	172	35	3	850e4c9e9003807c19695be4b13121b0808a9389
ToppCell	mild_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	FLNB RBMS3 ANKRD53	3.28e-04	172	35	3	dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell	droplet-Spleen-nan-18m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ECE1 PTGS2 TRPM2	3.28e-04	172	35	3	018d8160cfcb7882475620dc678f48a69a0f643e
ToppCell	CTRL-Myeloid-Neutrophil\|CTRL / Disease state, Lineage and Cell class	ECE1 PTGS2 ALPL	3.28e-04	172	35	3	ef3a6fe3b7300959f9f71130200c7fb8741c42b0
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB ECE1 RAPGEF4	3.34e-04	173	35	3	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC4A4 KCNIP2 ALPL	3.34e-04	173	35	3	e4d9a9a781acc531bc81c3fcee24d637e805c8e1
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRD SLC4A4 TRPM3	3.34e-04	173	35	3	8888434641ea554a9b62c436e87920378eef29cd
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNIP2 PTGS2 STK32B	3.40e-04	174	35	3	0df738309b7b6e77675ea74e7a87e66601b0073d
ToppCell	normal_Lung-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	SEPHS2 KCNIP2 ALPL	3.40e-04	174	35	3	e324320b52c904496e26fcecfa179b3431729ec0
ToppCell	BAL-Control-Myeloid-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLK FLNB ANKRD53	3.45e-04	175	35	3	6d5bdfbe53608e01c3845ecd908ca6d0fecc58f8
ToppCell	AT1-AT2_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	FLNB RBMS3 PTGS2	3.45e-04	175	35	3	bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCell	BAL-Control-Myeloid-pDC-pDC-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLK FLNB ANKRD53	3.45e-04	175	35	3	6839ee3bb4457d13cb08ca8eb79ae33ddd256783
ToppCell	BAL-Control-Myeloid-pDC-pDC\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BLK FLNB ANKRD53	3.45e-04	175	35	3	9d6135e183179968555670abec39dff9da2c3219
ToppCell	CF-Lymphoid-pDC\|CF / Disease state, Lineage and Cell class	BLK FLNB ANKRD53	3.51e-04	176	35	3	dd1e529a9e413bcaab43584afbe059e1464ffb53
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB ECE1 ANKRD53	3.51e-04	176	35	3	27e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB ECE1 ANKRD53	3.51e-04	176	35	3	d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHRR IGFBP5 HAP1	3.57e-04	177	35	3	84116796ca4c7007508c0f1a68a1135c7b922278
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FRY ECE1 RAPGEF4	3.57e-04	177	35	3	16197068260fc062bf8b730a51a199887ea580b9
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC4A4 KCNIP2 RBMS3	3.57e-04	177	35	3	91706bd0d4dda8d98843fb00b898d5aca4d66b64
ToppCell	COPD-Epithelial-Basal\|Epithelial / Disease state, Lineage and Cell class	MMP1 SLC4A4 ECE1	3.63e-04	178	35	3	441d1dba720141891b11f404744c59834d80e6c5
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHRR IGFBP5 HAP1	3.63e-04	178	35	3	3c973aac16988e88f5677d3d695dd772ccfd6570
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFBP5 ECE1 HAP1	3.63e-04	178	35	3	375156ba1c7b8592bf733c75f24968161f7cfa09
ToppCell	LPS-antiTNF-Myeloid-Neutrophils-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MMP1 PTGS2 TRPM2	3.63e-04	178	35	3	afcc92e8fe313c85eaf617cf4dbc3058da6c99d6
ToppCell	LPS-antiTNF-Myeloid-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MMP1 PTGS2 TRPM2	3.63e-04	178	35	3	bd689205bc92cda5f71df64c2332ff76adcd84b4
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-macrophage\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MERTK HAP1 TRPM2	3.63e-04	178	35	3	6c1b5087581ca8cea976d89ea6f34088c8fc3668
Drug	SMR 6	AHRR ALPL ALPP	3.32e-08	5	35	3	CID006439864
Drug	bosentan	TRPM1 ECE1 TRPM3 PTGS2 TRPM2	5.78e-07	106	35	5	CID000104865
Drug	zoledronic acid	MMP1 PTGS2 SLC4A9 ALPL ALPP	6.34e-07	108	35	5	CID000068740
Drug	AC1NRBPT	MMP1 IGFBP5 PTGS2 ALPL ALPP	4.68e-06	162	35	5	CID005288571
Drug	5-hydroxycytidine	ALPL ALPP	6.88e-06	3	35	2	CID000198207
Drug	Alphostatin	ALPL ALPP	6.88e-06	3	35	2	CID000174788
Drug	epoxy resin AH-26	PTGS2 ALPL	6.88e-06	3	35	2	ctd:C028044
Drug	Clioquinol [130-26-7]; Up 200; 13uM; MCF7; HT_HG-U133A	PTPRD SLC4A4 IGFBP5 TRPM3 RBMS3	1.02e-05	190	35	5	5623_UP
Drug	Trimipramine maleate salt [521-78-8]; Up 200; 9.8uM; MCF7; HT_HG-U133A	IGFBP5 ECE1 KCNIP2 HAP1 TRPM2	1.24e-05	198	35	5	3342_UP
Drug	3-indoxyl phosphate	ALPL ALPP	1.37e-05	4	35	2	CID000026292
Drug	p-bromotetramisole	ALPL ALPP	1.37e-05	4	35	2	CID000005121
Drug	ammediol	ALPL ALPP	1.37e-05	4	35	2	CID000001531
Drug	ethylethanolamine	ALPL ALPP	1.37e-05	4	35	2	CID000008072
Drug	etidronate	PTPRD ALPL ALPP	1.60e-05	32	35	3	CID000003305
Drug	dibutyryl cyclic 3',5'-AMP	AHRR MMP1 IGFBP5 P2RY11 PTGS2 ALPL ALPP	1.96e-05	561	35	7	CID000002460
Drug	Spirazon	MMP1 PTGS2 ALPL ALPP	2.00e-05	105	35	4	CID000004899
Drug	Fast Blue RR	ALPL ALPP	2.29e-05	5	35	2	CID000093116
Drug	1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin	MMP1 PTGS2	2.29e-05	5	35	2	ctd:C540360
Drug	ranelic acid	ALPL ALPP	2.29e-05	5	35	2	CID003052774
Drug	mitomycin phosphate	ALPL ALPP	2.29e-05	5	35	2	CID000130219
Drug	NAADP	TRPM3 P2RY11 TRPM2	2.93e-05	39	35	3	CID000123952
Drug	aluminum nitride	PTPRD ALPL ALPP	3.16e-05	40	35	3	CID000090455
Drug	dieckol	MMP1 PTGS2	3.43e-05	6	35	2	ctd:C503840
Drug	5-fluorosalicylic acid	ALPL ALPP	3.43e-05	6	35	2	CID000067658
Drug	FADP	ALPL ALPP	3.43e-05	6	35	2	CID003081481
Drug	AC1L4B0X	AHRR ALPL ALPP MPG	3.61e-05	122	35	4	CID000153769
Drug	sulfaphenazole	FLNB AHRR PTGS2	4.22e-05	44	35	3	CID000005335
Drug	p-aminodiphenylamine	ALPL ALPP	4.80e-05	7	35	2	CID000007564
Drug	dimercaprol	ECE1 ALPL ALPP	5.49e-05	48	35	3	CID000003080
Drug	heliotrine	MMP1 PTPRD RAPGEF4	5.49e-05	48	35	3	ctd:C010178
Drug	A-432411	MMP1 ECE1	6.39e-05	8	35	2	CID010125830
Drug	fosfosal	ALPL ALPP	6.39e-05	8	35	2	CID000003418
Drug	iopentol	ALPL ALPP	6.39e-05	8	35	2	CID000056016
Drug	(1S,2E,3S)-2-[(2E)-2-[(7aR)-7a-methyl-1-[(E,1R,4R)-1,4,5-trimethylhex-2-enyl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-3-methyl-cyclohexanol	ALPL ALPP	6.39e-05	8	35	2	CID011953890
Drug	orellanine	ALPL ALPP	6.39e-05	8	35	2	CID000089579
Drug	berberine	MMP1 TRPM3 HAP1 PTGS2 MPG	6.51e-05	280	35	5	CID000002353
Drug	sodium	TRPM1 MMP1 MERTK SLC4A4 TRPM3 SLC4A9 TRPM2 MPG	7.35e-05	944	35	8	CID000000923
Drug	glycyl-L-leucine	MMP1 ALPL ALPP	7.82e-05	54	35	3	CID000092843
Drug	6MNA	MMP1 PTGS2	8.21e-05	9	35	2	CID000032176
Drug	aminohexane	ALPL ALPP	8.21e-05	9	35	2	CID000201427
Drug	AC1Q5BBB	PTGS2 ALPL	8.21e-05	9	35	2	CID000160467
Drug	phenolphthalein monophosphate	ALPL ALPP	8.21e-05	9	35	2	CID000128862
Drug	Aphos	ALPL ALPP	8.21e-05	9	35	2	CID000053051
Drug	6-Mna	MMP1 PTGS2	8.21e-05	9	35	2	CID000030861
Drug	fosfluconazole	ALPL ALPP	8.21e-05	9	35	2	CID000214356
Drug	naphthol AS-TR	ALPL ALPP	8.21e-05	9	35	2	CID000066718
Drug	fulvestrant	AHRR MMP1 ARID1A ECE1 PTGS2 ALPL	8.60e-05	484	35	6	ctd:C070081
Drug	lutein G	MMP1 ALPL ALPP	9.69e-05	58	35	3	CID000181579
Drug	photobiotin	ALPL ALPP	1.03e-04	10	35	2	CID003035428
Drug	Adrenal Cortex Hormones	ECE1 ALPL	1.03e-04	10	35	2	ctd:D000305
Drug	naphthol AS-MX	ALPL ALPP	1.03e-04	10	35	2	CID000066717
Drug	Glucosamine	MMP1 SLC4A4 IGFBP5 PTGS2 ALPL	1.07e-04	311	35	5	ctd:D005944
Drug	Lansoprazole	RETSAT PTGS2 ALPL	1.13e-04	61	35	3	ctd:D064747
Drug	senkirkine	MMP1 PTPRD RAPGEF4	1.13e-04	61	35	3	ctd:C009238
Drug	4-aminophenyl	MMP1 ALPL ALPP	1.18e-04	62	35	3	CID000181201
Drug	sodium cromoglycate	PTGS2 ALPL ALPP	1.24e-04	63	35	3	CID000002881
Drug	855 sigma	ALPL ALPP	1.25e-04	11	35	2	CID000074136
Drug	BIAP	ALPL ALPP	1.25e-04	11	35	2	CID005487027
Drug	AttoPhos	ALPL ALPP	1.25e-04	11	35	2	CID000188920
Drug	forphenicine	ALPL ALPP	1.25e-04	11	35	2	CID000042560
Drug	anthracene	AHRR PTGS2	1.25e-04	11	35	2	ctd:C034020
Drug	chloride	MMP1 MERTK SLC4A4 P2RY11 PTGS2 SLC4A9 ALPL ALPP	1.34e-04	1029	35	8	CID000000312
Drug	Pyrrolizidine Alkaloids	MMP1 PTPRD RAPGEF4	1.42e-04	66	35	3	ctd:D011763
Drug	homoarginine hydrochloride	BLK ALPL ALPP	1.42e-04	66	35	3	CID000003625
Drug	clodronate	MMP1 ALPL ALPP	1.49e-04	67	35	3	CID000025419
Drug	vitamin K2	SLC4A4 ALPL ALPP	1.49e-04	67	35	3	CID000004056
Drug	AC1L48S9	ALPL ALPP	1.50e-04	12	35	2	CID000152644
Drug	2-amino-2-methyl-1-propanol	ALPL ALPP	1.50e-04	12	35	2	CID000011807
Drug	Peptides	MMP1 PTGS2	1.50e-04	12	35	2	ctd:D010455
Drug	methylprednisolone acetate	MMP1 PTGS2	1.50e-04	12	35	2	ctd:C000873
Drug	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	AHRR MMP1 PTGS2 ALPL MPG	1.53e-04	336	35	5	ctd:C511621
Drug	4 alpha-phorbol 12,13-didecanoate	TRPM3 PTGS2 TRPM2	1.70e-04	70	35	3	CID000452543
Drug	AMPPD	ALPL ALPP	1.77e-04	13	35	2	CID000064599
Drug	AC1L38JC	ALPL ALPP	1.77e-04	13	35	2	CID000084962
Drug	ferrous lactate	ALPL ALPP	1.77e-04	13	35	2	CID000022197
Drug	atropine sulfate	MMP1 HAP1 PTGS2 ALPL ALPP	1.78e-04	347	35	5	CID000003661
Drug	Podophyllotoxin [518-28-5]; Up 200; 9.6uM; PC3; HT_HG-U133A	GIT2 SLC4A4 RBMS3 PTGS2	1.89e-04	187	35	4	5841_UP
Drug	senecionine	MMP1 PTPRD RAPGEF4	2.00e-04	74	35	3	ctd:C009237
Drug	PNU-0230031 [267429-39-0]; Up 200; 10uM; MCF7; HT_HG-U133A	ECE1 RBMS3 ALPL TRPM2	2.01e-04	190	35	4	3629_UP
Drug	Prostaglandin E1; Up 200; 10uM; PC3; HT_HG-U133A	GIT2 ECE1 HAP1 PTGS2	2.01e-04	190	35	4	6555_UP
Drug	beta3-adrenoceptor agonist	AHRR PTGS2	2.07e-04	14	35	2	CID006439232
Drug	N-(p-amylcinnamoyl)anthranilic acid	TRPM3 TRPM2	2.07e-04	14	35	2	CID000001974
Drug	ELF-97	ALPL ALPP	2.07e-04	14	35	2	CID000132799
Drug	1 alpha OHD2	ALPL ALPP	2.07e-04	14	35	2	CID004479094
Drug	cannabidiol hydroxyquinone	MMP1 PTGS2	2.07e-04	14	35	2	ctd:C073718
Drug	3-acetylpyridine	TRPM1 IGFBP5 TRPM3	2.08e-04	75	35	3	CID000009589
Drug	Ajmaline [4360-12-7]; Down 200; 12.2uM; HL60; HG-U133A	CPSF1 FLNB GIT2 ARID1A	2.13e-04	193	35	4	1749_DN
Drug	Oxantel pamoate [68813-55-8]; Up 200; 6.6uM; PC3; HT_HG-U133A	BLK RBMS3 HAP1 PTGS2	2.18e-04	194	35	4	6738_UP
Drug	Dirithromycin [62013-04-1]; Down 200; 4.8uM; HL60; HG-U133A	CPSF1 FLNB GIT2 ARID1A	2.18e-04	194	35	4	1712_DN
Drug	p-nitrophenyl phosphate	PTPRD SLC4A9 ALPL ALPP	2.18e-04	194	35	4	CID000000378
Drug	Tolbutamide [64-77-7]; Up 200; 14.8uM; PC3; HT_HG-U133A	FRY TRPM1 ALPL ALPP	2.22e-04	195	35	4	3804_UP
Drug	Kawain [500-64-1]; Down 200; 17.4uM; PC3; HT_HG-U133A	SLC4A4 HAP1 PTGS2 ALPP	2.22e-04	195	35	4	3670_DN
Drug	Clopamide [636-54-4]; Down 200; 11.6uM; HL60; HG-U133A	CPSF1 GIT2 ARID1A MPG	2.22e-04	195	35	4	1605_DN
Drug	Phenethicillin potassium salt [132-93-4]; Down 200; 10uM; PC3; HT_HG-U133A	SLC4A4 IGFBP5 ARID1A PTGS2	2.22e-04	195	35	4	5763_DN
Drug	colchicine; Down 200; 1uM; SKMEL5; HG-U133A	CPSF1 FLNB GIT2 MERTK	2.22e-04	195	35	4	630_DN
Drug	Hydroquinine hydrobromide hydrate [304695-81-6]; Up 200; 9.4uM; MCF7; HT_HG-U133A	IGFBP5 ARID1A HAP1 TRPM2	2.22e-04	195	35	4	2767_UP
Drug	Methoxy-8-psoralen [298-81-7]; Down 200; 18.6uM; PC3; HT_HG-U133A	GIT2 SLC4A4 ARID1A PTGS2	2.22e-04	195	35	4	6661_DN
Drug	Bambuterol hydrochloride [81732-46-9]; Up 200; 10uM; MCF7; HT_HG-U133A	CPSF1 MERTK IGFBP5 HAP1	2.22e-04	195	35	4	3199_UP
Drug	Beraprost-d3	PTGS2 ALPL ALPP	2.25e-04	77	35	3	CID000002352
Drug	Lobeline alpha (-) hydrochoride [134-63-4]; Down 200; 10.6uM; HL60; HG-U133A	CPSF1 GIT2 ARID1A YJU2B	2.26e-04	196	35	4	1770_DN
Disease	ulcerative colitis (implicated_via_orthology)	MMP1 PTGS2	2.54e-05	7	33	2	DOID:8577 (implicated_via_orthology)
Disease	MASA syndrome (implicated_via_orthology)	TRPM1 TRPM3	2.54e-05	7	33	2	DOID:0060246 (implicated_via_orthology)
Disease	pulmonary hypertension (implicated_via_orthology)	MMP1 ECE1 PTGS2	3.04e-05	54	33	3	DOID:6432 (implicated_via_orthology)
Disease	aspartate aminotransferase measurement	BLK FLNB MERTK PTPRD SLC4A4 TRPM3 RBMS3	5.27e-05	904	33	7	EFO_0004736
Disease	esophagus adenocarcinoma (is_marker_for)	ARID1A PTGS2	7.95e-05	12	33	2	DOID:4914 (is_marker_for)
Disease	Dental enamel hypoplasia	PTPRD SLC4A4	7.95e-05	12	33	2	EFO_1001304
Disease	Adenocarcinoma Of Esophagus	ARID1A PTGS2	1.09e-04	14	33	2	C0279628
Disease	glycerol-3-phosphate measurement	ECE1 ALPL	1.26e-04	15	33	2	EFO_0010488
Disease	anemia (implicated_via_orthology)	SLC4A4 SLC4A9	1.26e-04	15	33	2	DOID:2355 (implicated_via_orthology)
Disease	hemorheological measurement	PTPRD STK32B	1.26e-04	15	33	2	EFO_0803374
Disease	Oral Submucous Fibrosis	MMP1 PTGS2	1.84e-04	18	33	2	C0029172
Disease	Colorectal Neoplasms	MMP1 PTPRD ARID1A PTGS2	2.51e-04	277	33	4	C0009404
Disease	in situ carcinoma (is_marker_for)	PTGS2 ALPL	2.51e-04	21	33	2	DOID:8719 (is_marker_for)
Disease	idiopathic pulmonary fibrosis (is_marker_for)	MMP1 PTGS2	3.02e-04	23	33	2	DOID:0050156 (is_marker_for)
Disease	Breast Carcinoma	MMP1 PTPRD IGFBP5 ARID1A PTGS2	3.08e-04	538	33	5	C0678222
Disease	Intrahepatic Cholangiocarcinoma	ARID1A PTGS2	3.30e-04	24	33	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	ARID1A PTGS2	3.30e-04	24	33	2	C3805278
Disease	digestive system infectious disorder	FLNB RBMS3	3.88e-04	26	33	2	MONDO_0043424
Disease	Cholangiocarcinoma	ARID1A PTGS2	3.88e-04	26	33	2	C0206698
Disease	acute kidney failure (implicated_via_orthology)	ECE1 PTGS2	4.18e-04	27	33	2	DOID:3021 (implicated_via_orthology)
Disease	amyotrophic lateral sclerosis (is_marker_for)	MMP1 PTGS2	4.83e-04	29	33	2	DOID:332 (is_marker_for)
Disease	Bladder Neoplasm	IGFBP5 ARID1A PTGS2	5.14e-04	140	33	3	C0005695
Disease	Malignant neoplasm of urinary bladder	IGFBP5 ARID1A PTGS2	5.25e-04	141	33	3	C0005684
Disease	arteriosclerosis (is_implicated_in)	MMP1 PTGS2	5.53e-04	31	33	2	DOID:2349 (is_implicated_in)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	MERTK ARID1A PTGS2	6.04e-04	148	33	3	C0279702
Disease	systemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus	BLK FLNB	8.31e-04	38	33	2	EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
Disease	dilated cardiomyopathy (is_marker_for)	MMP1 ECE1	8.76e-04	39	33	2	DOID:12930 (is_marker_for)
Disease	congestive heart failure (implicated_via_orthology)	MMP1 ECE1	9.68e-04	41	33	2	DOID:6000 (implicated_via_orthology)
Disease	Carcinoma, Transitional Cell	ARID1A PTGS2	9.68e-04	41	33	2	C0007138
Disease	aortic stenosis, aortic valve calcification	FLNB ALPL	1.02e-03	42	33	2	EFO_0000266, EFO_0005239
Disease	Malignant neoplasm of breast	FLNB MMP1 PTPRD IGFBP5 ARID1A PTGS2	1.09e-03	1074	33	6	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
TRGYPMEDMKLQGVP	AHRR	506	A9YTQ3
GAPKMVEYSQYGLGM	ACSM6	231	Q6P461
PMPVLYGIFLYMGVA	SLC4A9	836	Q96Q91
RPMSMYETGSGQKPY	GIT2	511	Q14161
MGKRLDQPQMYPQYT	RBMS3	1	Q6XE24
MGRMSYEPNKDPYGS	ARID1A	1221	O14497
YRMKVPQGFYPISMR	ANKRD53	466	Q8N9V6
ELGPYVGYQVMRGLM	P2RY11	296	Q96G91
RGMTPYPGVQNHEMY	MERTK	796	Q12866
YMYLPEAKESFGGMR	CPSF1	1281	Q10570
EGYKVMYTPMAPGNY	FLNB	2436	O75369
MMGKYTYPALREEAP	KCNIP2	211	Q9NS61
GKMKYQIIDGEMYPP	PTGS2	236	P35354
KYGMKLPGMEYVDGD	IGFBP5	246	P24593
RKYMFRMGTPDPEYP	ALPP	226	P05187
DVIMGGGRKYMYPKN	ALPL	216	P05186
EEGMMINISIGYRYP	ERVK-24	36	P61566
EEGMMINISIGYRYP	ERVK-7	36	P61567
MEVVTYGRVPYPGMS	BLK	426	P51451
DPVYFMERNYEMPRG	HAP1	501	P54257
NRGMFMKPGTLYVYI	MPG	146	P29372
YNMIGYPNFIMDPKE	ECE1	501	P42892
YMTAKYGDEVPGPEM	FRY	1421	Q5TBA9
YVRMENGEPKGQPML	PTPRD	751	P23468
KMPGKMGNIYRTEYG	MRPL3	256	P09001
MVLEGPNGRKEYPMY	RETSAT	156	Q6NUM9
PNGRKEYPMYSGEKA	RETSAT	161	Q6NUM9
RQYMAGLLAPPYGVM	RAPGEF4	151	Q8WZA2
DEYKRSMDPGYPKMI	MMP1	401	P03956
PRTGVSEYPPYMMKR	FSD2	96	A1L4K1
YPLVEDPYMMGRIAC	SEPHS2	141	Q99611
DIFGVNKYLGPYVMM	TRPM3	1011	Q9HCF6
GMEVYKGYMDDPRNT	TRPM2	1421	O94759
VYYMPEPQSGRVQGM	TEX13C	206	A0A0J9YWL9
MGERKGVNKYYPPDF	YJU2B	1	P13994
FGVNKYLGPYVMMIG	TRPM1	946	Q7Z4N2
PMPVLYGVFLYMGVA	SLC4A4	901	Q9Y6R1
YMAPEVFQVYMDRGP	STK32B	186	Q9NY57