Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	6.56e-05	3	94	2	GO:0018858
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	1.31e-04	4	94	2	GO:0102391
GeneOntologyMolecularFunction	fatty acid ligase activity	SLC27A1 ACSM2A ACSM2B	2.43e-04	26	94	3	GO:0015645
GeneOntologyMolecularFunction	CoA-ligase activity	SLC27A1 ACSM2A ACSM2B	2.72e-04	27	94	3	GO:0016405
GeneOntologyMolecularFunction	acid-thiol ligase activity	SLC27A1 ACSM2A ACSM2B	4.13e-04	31	94	3	GO:0016878
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM2A ACSM2B	6.03e-04	8	94	2	GO:0004321
Domain	-	PHLDA1 ARHGAP10 CYTH1 OBSCN TRIOBP TEC ARHGEF17 SH2D5 PLEKHH3 TLN2 AKAP13 ADAP2	5.42e-07	391	93	12	2.30.29.30
Domain	PH_dom-like	PHLDA1 ARHGAP10 CYTH1 OBSCN TRIOBP TEC ARHGEF17 SH2D5 PLEKHH3 TLN2 AKAP13 ADAP2	1.33e-06	426	93	12	IPR011993
Domain	PH	PHLDA1 ARHGAP10 CYTH1 OBSCN TRIOBP TEC PLEKHH3 AKAP13 ADAP2	1.02e-05	278	93	9	SM00233
Domain	PH_DOMAIN	PHLDA1 ARHGAP10 CYTH1 OBSCN TRIOBP TEC PLEKHH3 AKAP13 ADAP2	1.05e-05	279	93	9	PS50003
Domain	PH_domain	PHLDA1 ARHGAP10 CYTH1 OBSCN TRIOBP TEC PLEKHH3 AKAP13 ADAP2	1.08e-05	280	93	9	IPR001849
Domain	AMP-bd_C	SLC27A1 ACSM2A ACSM2B	7.73e-05	17	93	3	IPR025110
Domain	AMP-binding_C	SLC27A1 ACSM2A ACSM2B	7.73e-05	17	93	3	PF13193
Domain	PH	ARHGAP10 CYTH1 OBSCN TRIOBP TEC AKAP13 ADAP2	1.47e-04	229	93	7	PF00169
Domain	AMP-binding_CS	SLC27A1 ACSM2A ACSM2B	2.86e-04	26	93	3	IPR020845
Domain	AMP_BINDING	SLC27A1 ACSM2A ACSM2B	3.58e-04	28	93	3	PS00455
Domain	AMP-binding	SLC27A1 ACSM2A ACSM2B	4.40e-04	30	93	3	PF00501
Domain	AMP-dep_Synth/Lig	SLC27A1 ACSM2A ACSM2B	4.40e-04	30	93	3	IPR000873
Domain	IRF-3	IRF7 IRF9	5.07e-04	7	93	2	PF10401
Domain	Interferon_reg_factor-3	IRF7 IRF9	5.07e-04	7	93	2	IPR019471
Domain	IRF-3	IRF7 IRF9	5.07e-04	7	93	2	SM01243
Domain	IRF	IRF7 IRF9	8.63e-04	9	93	2	SM00348
Domain	Interferon_reg_fact_DNA-bd_dom	IRF7 IRF9	8.63e-04	9	93	2	IPR001346
Domain	IRF	IRF7 IRF9	8.63e-04	9	93	2	PF00605
Domain	IRF_1	IRF7 IRF9	8.63e-04	9	93	2	PS00601
Domain	Interferon_reg_fac_CS	IRF7 IRF9	8.63e-04	9	93	2	IPR019817
Domain	IRF_2	IRF7 IRF9	8.63e-04	9	93	2	PS51507
Domain	PROTEIN_KINASE_TYR	PDGFRA OBSCN TEC FGFR4	1.40e-03	97	93	4	PS00109
Domain	Tyr_kinase_AS	PDGFRA OBSCN TEC FGFR4	1.40e-03	97	93	4	IPR008266
Domain	TIL	VWF ZAN	1.57e-03	12	93	2	PF01826
Domain	C8	VWF ZAN	1.57e-03	12	93	2	PF08742
Domain	Unchr_dom_Cys-rich	VWF ZAN	1.85e-03	13	93	2	IPR014853
Domain	C8	VWF ZAN	1.85e-03	13	93	2	SM00832
Domain	TIL_dom	VWF ZAN	2.15e-03	14	93	2	IPR002919
Domain	Methyltransf_11	COQ3 METTL13	2.81e-03	16	93	2	PF08241
Domain	VWD	VWF ZAN	2.81e-03	16	93	2	SM00216
Domain	VWF_type-D	VWF ZAN	2.81e-03	16	93	2	IPR001846
Domain	VWFD	VWF ZAN	2.81e-03	16	93	2	PS51233
Domain	SMAD_dom-like	IRF7 IRF9	2.81e-03	16	93	2	IPR017855
Domain	-	IRF7 IRF9	2.81e-03	16	93	2	2.60.200.10
Domain	Methyltransf_11	COQ3 METTL13	2.81e-03	16	93	2	IPR013216
Domain	VWD	VWF ZAN	2.81e-03	16	93	2	PF00094
Domain	DH_1	OBSCN ARHGEF17 AKAP13	3.82e-03	63	93	3	PS00741
Domain	VWC_out	VWF ZAN	3.97e-03	19	93	2	SM00215
Domain	RhoGEF	OBSCN ARHGEF17 AKAP13	4.74e-03	68	93	3	SM00325
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	OBSCN TSC2 ARHGEF17 HNRNPF SCAF1 LOXHD1 MOGS FAM120C ABCD3 AKAP13 CDK5R2	7.47e-06	736	98	11	29676528
Pubmed	Tuberin and p27 expression in breast cancer patients with or without BRCA germline mutations.	TSC2 PSMD9	7.86e-06	2	98	2	23689538
Pubmed	Differential regulation of cyclin-dependent kinase inhibitors in neuroblastoma cells.	CDKN1A PSMD9	7.86e-06	2	98	2	23618860
Pubmed	Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways.	CDKN1A GLYR1	7.86e-06	2	98	2	32370786
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	7.86e-06	2	98	2	19634011
Pubmed	Azacitidine Mitigates Graft-versus-Host Disease via Differential Effects on the Proliferation of T Effectors and Natural Regulatory T Cells In Vivo.	CDKN1A FOXP3	7.86e-06	2	98	2	28330901
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	7.86e-06	2	98	2	16521160
Pubmed	FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing.	HNRNPF FOXP3	7.86e-06	2	98	2	29773655
Pubmed	Transcription factor redundancy ensures induction of the antiviral state.	IRF7 IRF9	7.86e-06	2	98	2	20943654
Pubmed	Tumoral FOXP3 expression is associated with favorable clinicopathological variables and good prognosis in gastric adenocarcinoma: the tumor suppressor function of tumoral FOXP3 is related with the P21 expression in gastric adenocarcinoma.	CDKN1A FOXP3	7.86e-06	2	98	2	28882702
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	7.86e-06	2	98	2	29948332
Pubmed	Deficiency of heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21cip1 expression.	CDKN1A HSF4	7.86e-06	2	98	2	34339841
Pubmed	VWF maturation and release are controlled by 2 regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2.	VWF HPS6	7.86e-06	2	98	2	32614949
Pubmed	Decreased p21 expression in HPV-18 positive cervical carcinomas.	CDKN1A PSMD9	2.35e-05	3	98	2	19657726
Pubmed	Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis.	CDKN1A PDGFRA	2.35e-05	3	98	2	23448253
Pubmed	Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer.	CDKN1A PSMD9	2.35e-05	3	98	2	18694622
Pubmed	Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels.	CDKN1A PSMD9	2.35e-05	3	98	2	19041685
Pubmed	Foxp3 is a key downstream regulator of p53-mediated cellular senescence.	CDKN1A FOXP3	2.35e-05	3	98	2	27238838
Pubmed	DNA methylation impairs TLR9 induced Foxp3 expression by attenuating IRF-7 binding activity in fulminant type 1 diabetes.	IRF7 FOXP3	2.35e-05	3	98	2	23490285
Pubmed	Platelet-derived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis.	VWF PDGFRA	2.35e-05	3	98	2	7502236
Pubmed	The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.	CDKN1A FOXP3	2.35e-05	3	98	2	24777532
Pubmed	Platelet-derived growth factor (PDGF) receptor-alpha-activated c-Jun NH2-terminal kinase-1 is critical for PDGF-induced p21WAF1/CIP1 promoter activity independent of p53.	CDKN1A PDGFRA	2.35e-05	3	98	2	14506245
Pubmed	Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.	PDGFRA TEC FGFR4	2.39e-05	20	98	3	7893599
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	WDR36 CYTH1 TRIOBP HNRNPF ITIH4 PLEKHH3 EPM2AIP1 MOGS ABCD3 GNAI3	4.25e-05	732	98	10	34732716
Pubmed	BLOC-2 subunit HPS6 deficiency affects the tubulation and secretion of von Willebrand factor from mouse endothelial cells.	VWF HPS6	4.70e-05	4	98	2	27889498
Pubmed	Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway.	IRF7 TSC2	4.70e-05	4	98	2	25476905
Pubmed	FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus.	CDKN1A FOXP3	4.70e-05	4	98	2	19276356
Pubmed	Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.	ACSM2A ACSM2B	4.70e-05	4	98	2	32830538
Pubmed	An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.	IRF7 IRF9 FOXP3	5.38e-05	26	98	3	33238123
Pubmed	TLR6: A novel member of an expanding toll-like receptor family.	PDGFRA TEC	7.82e-05	5	98	2	10231569
Pubmed	Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit.	PDGFRA TEC	7.82e-05	5	98	2	7678927
Pubmed	FGF receptors control alveolar elastogenesis.	PDGFRA FGFR4	7.82e-05	5	98	2	29122839
Pubmed	CRL4AMBRA1 is a master regulator of D-type cyclins.	CDKN1A DCAF10 LRRC41	8.33e-05	30	98	3	33854235
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MAP6 CYTH1 DDN TRIOBP TSC2 PLA2G15 ITIH4 EPM2AIP1 FAM120C SVIL TLN2	8.66e-05	963	98	11	28671696
Pubmed	microRNA-200a downregulation in human glioma leads to Gαi1 over-expression, Akt activation, and cell proliferation.	PDGFRA METTL13	1.17e-04	6	98	2	29520106
Pubmed	Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection.	IRF7 IRF9	1.17e-04	6	98	2	15919906
Pubmed	The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia.	CDKN1A VWF	1.17e-04	6	98	2	34816104
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	B4GALT7 EMC4 ELOVL5 TSC2 PLA2G15 MOGS GLYR1 SVIL FLCN GNAI3 FGFR4 TAPBP	1.44e-04	1201	98	12	35696571
Pubmed	Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process.	IRF7 IRF9	1.64e-04	7	98	2	20083668
Pubmed	Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity.	CDKN1A PHLDA1	1.64e-04	7	98	2	22802351
Pubmed	Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.	PDGFRA FOXP3	1.64e-04	7	98	2	30824323
Pubmed	Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression.	IRF7 IRF9	1.64e-04	7	98	2	22252317
Pubmed	Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.	PDGFRA FOXP3	1.64e-04	7	98	2	35139352
Pubmed	Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection.	IRF7 IRF9	1.64e-04	7	98	2	29562174
Pubmed	Mutation of ARHGAP9 in patients with coronary spastic angina.	ARHGAP10 ARHGEF17 AKAP13	1.70e-04	38	98	3	19911011
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	OBSCN ARHGEF17 AKAP13	1.70e-04	38	98	3	11756498
Pubmed	Pejvakin, a Candidate Stereociliary Rootlet Protein, Regulates Hair Cell Function in a Cell-Autonomous Manner.	TRIOBP ABCD3	2.18e-04	8	98	2	28209736
Pubmed	Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor.	CDKN1A PDGFRA	2.18e-04	8	98	2	10885750
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	OBSCN ARHGEF17 AKAP13	2.47e-04	43	98	3	12376548
Pubmed	An essential role for Cmtr2 in mammalian embryonic development.	CDKN1A IRF7	2.79e-04	9	98	2	39094818
Pubmed	Mapping of nine porcine interferon regulatory factor genes.	IRF7 IRF9	2.79e-04	9	98	2	17121613
Pubmed	Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh mutation on mouse chromosome 5 is associated with an inversion.	PDGFRA TEC	2.79e-04	9	98	2	8589683
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPPK1 CYTH1 OBSCN TSC2 MBD6 PLEKHH3 SCAF1 HPS6 FLCN TLN2 AKAP13	2.85e-04	1105	98	11	35748872
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	B4GALT7 WDR36 ARHGAP10 CYTH1 TAF1C TRIOBP NDUFB3 SCAF1 CCDC59 FAM120C ABCD3 MPHOSPH8 TAPBP	2.95e-04	1497	98	13	31527615
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	WAPL DCDC1 PHLDA1 ARHGAP10 TAF1C ITIH4 SCAF1 METTL13 FAM120C TIGD5 LRRC41	3.10e-04	1116	98	11	31753913
Pubmed	Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.	VWF ITIH4 HP	3.21e-04	47	98	3	14760718
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	SETMAR TSC2 PSMD9 METTL13 MOGS DCAF10 HPS6 LRRC41	3.23e-04	606	98	8	36538041
Pubmed	Transcriptome analysis of human gastric cancer.	GPD2 EPPK1 C2CD4A IRF7 PSMD9 NDUFB3 METTL13 CCDC59 HSF4	3.38e-04	772	98	9	16341674
Pubmed	Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression.	IRF7 IRF9	3.48e-04	10	98	2	20637660
Pubmed	IRF-7 is the master regulator of type-I interferon-dependent immune responses.	IRF7 IRF9	3.48e-04	10	98	2	15800576
Pubmed	OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc.	PDGFRA FGFR4	4.25e-04	11	98	2	28628118
Pubmed	Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages.	IRF7 IRF9	4.25e-04	11	98	2	25049377
Pubmed	Gestational loss and growth restriction by angiogenic defects in placental growth factor transgenic mice.	VWF FOXP3	4.25e-04	11	98	2	25147341
Pubmed	Defining the membrane proteome of NK cells.	PDGFRA ELOVL5 DHRS13 HNRNPF MOGS SLC27A1 HPS6 ABCD3 AKAP13 GNAI3 LRRC41	4.55e-04	1168	98	11	19946888
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	GPD2 WAPL WDR36 PDGFRA HNRNPF SCAF1 GLYR1 ABCD3 MPHOSPH8 ATP6V1C2	4.83e-04	989	98	10	36424410
Pubmed	Completion of the entire hepatitis C virus life cycle in genetically humanized mice.	IRF7 IRF9	5.09e-04	12	98	2	23903655
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	WAPL HNRNPF CEMIP MOGS ABCD3 AKAP13 PPIP5K2 LRRC41	5.13e-04	650	98	8	38777146
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	VWF TRIOBP HNRNPF EPM2AIP1 SVIL PPIP5K2	5.58e-04	360	98	6	33111431
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	CDKN1A WDR36 EMC4 PHLDA1 NDUFB3 HNRNPF EPM2AIP1 MOGS SLC27A1 ABCD3 GNAI3	5.81e-04	1203	98	11	29180619
Pubmed	Initial Suppression of Transforming Growth Factor-β Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia.	VWF PDGFRA	6.01e-04	13	98	2	26878215
Pubmed	Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β.	IRF7 IRF9	6.01e-04	13	98	2	28468974
Pubmed	Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut.	PDGFRA ABCD3	6.01e-04	13	98	2	36504079
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	WAPL WDR36 TRIOBP SVIL GNAI3 PPIP5K2	6.53e-04	371	98	6	15747579
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	OBSCN ARHGEF17 AKAP13	6.61e-04	60	98	3	12787561
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GPD2 WAPL WDR36 PLA2G15 HNRNPF SCAF1 METTL13 MOGS GLYR1 ABCD3 TLN2 MPHOSPH8	6.72e-04	1425	98	12	30948266
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	GPD2 VWF MAP6 ARHGEF17 NDUFB3 HNRNPF FAM120C SLC27A1 SVIL ABCD3 TLN2 ALDH7A1	6.97e-04	1431	98	12	37142655
Pubmed	Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.	TRIOBP GNAI3	7.00e-04	14	98	2	26754646
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	GPD2 COQ3 TIMMDC1 NDUFB3 PLA2G15 ABCD3 ACSM2A ALDH7A1 ACSM2B SLC25A45	7.50e-04	1047	98	10	18614015
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	GPD2 EMC4 PDGFRA PHLDA1 ELOVL5 COQ3 TIMMDC1 NDUFB3 MOGS FAM120C ABCD3 TAPBP	7.86e-04	1451	98	12	30550785
Pubmed	USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.	IRF7 IRF9	8.06e-04	15	98	2	27721430
Pubmed	Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.	IRF7 HPS6	8.06e-04	15	98	2	21045126
Pubmed	RGS12 polarizes the GPSM2-GNAI complex to organize and elongate stereocilia in sensory hair cells.	TRIOBP GNAI3	8.06e-04	15	98	2	36260679
Pubmed	Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.	IRF7 IRF9	8.06e-04	15	98	2	24362933
Pubmed	Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method.	PHLDA1 IRF9	9.19e-04	16	98	2	9417904
Pubmed	Dual role of Fam208a during zygotic cleavage and early embryonic development.	SVIL MPHOSPH8	9.19e-04	16	98	2	34216590
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	EPPK1 METTL13 HPS6 ABCD3 GNAI3	9.28e-04	264	98	5	32814769
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	GPD2 MAP6 CYTH1 TRIOBP HNRNPF MOGS GLYR1 ABCD3 MPHOSPH8 PPIP5K2	9.62e-04	1082	98	10	38697112
Pubmed	The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.	IRF7 IRF9	1.04e-03	17	98	2	25774715
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	CDKN1A TSC2 MOGS CYP4F12 FGFR4	1.13e-03	276	98	5	28319085
Pubmed	Loss of hepatocyte cell division leads to liver inflammation and fibrosis.	CDKN1A PDGFRA	1.17e-03	18	98	2	33147210
Pubmed	Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.	TEC FGFR4	1.17e-03	18	98	2	8521822
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	EMC4 PDGFRA TSC2 CHKA TIMMDC1 HNRNPF SCAF1 MOGS FLCN MPHOSPH8 LRRC41	1.29e-03	1327	98	11	32694731
Pubmed	PBX transcription factors drive pulmonary vascular adaptation to birth.	VWF PDGFRA	1.30e-03	19	98	2	29251627
Pubmed	Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.	IRF7 IRF9	1.44e-03	20	98	2	32150572
Pubmed	Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy.	EMC4 DERA GLYR1 ABCD3 ALDH7A1	1.45e-03	292	98	5	35545034
Pubmed	Next-generation sequencing to generate interactome datasets.	CDKN1A SGCA PSMD9 HNRNPF EPM2AIP1 METTL13 PLPP1 FAM120C GNAI3 ATP6V1C2	1.49e-03	1147	98	10	21516116
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	PHLDA1 HNRNPF MOGS FAM120C GLYR1 ABCD3 AKAP13	1.59e-03	601	98	7	33658012
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	B4GALT7 SCAF1 METTL13 DCAF10 HPS6 ABCD3 LRRC41	1.63e-03	604	98	7	38803224
Pubmed	The protein tyrosine kinase family of the human genome.	PDGFRA TEC FGFR4	1.69e-03	83	98	3	11114734
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	EPPK1 OBSCN ABCD3 ACSM2A ALDH7A1	1.73e-03	304	98	5	32235678
Cytoband	2p13.1	C2orf81 MOGS TTC31	5.38e-05	34	98	3	2p13.1
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CYTH1 TRIOBP TEC PLEKHH3 AKAP13 ADAP2	5.03e-05	206	58	6	682
GeneFamily	Acyl-CoA synthetase family	SLC27A1 ACSM2A ACSM2B	7.73e-05	26	58	3	40
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OBSCN ARHGEF17 AKAP13	1.24e-03	66	58	3	722
Disease	X-21319 measurement	ACSM2A ACSM2B	1.05e-05	2	96	2	EFO_0800807
Disease	Paroxysmal atrial fibrillation	CDKN1A VWF PHLDA1 SGCA ARHGAP10 CYTH1	1.24e-05	156	96	6	C0235480
Disease	familial atrial fibrillation	CDKN1A VWF PHLDA1 SGCA ARHGAP10 CYTH1	1.24e-05	156	96	6	C3468561
Disease	Persistent atrial fibrillation	CDKN1A VWF PHLDA1 SGCA ARHGAP10 CYTH1	1.24e-05	156	96	6	C2585653
Disease	Atrial Fibrillation	CDKN1A VWF PHLDA1 SGCA ARHGAP10 CYTH1	1.43e-05	160	96	6	C0004238
Disease	X-11478 measurement	ACSM2A ACSM2B	3.14e-05	3	96	2	EFO_0021242
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	6.26e-05	4	96	2	EFO_0020830
Disease	hypertension (biomarker_via_orthology)	VWF PDGFRA HP CYP4F12 GNAI3 FOXP3	1.01e-04	227	96	6	DOID:10763 (biomarker_via_orthology)
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	1.04e-04	5	96	2	EFO_0800378
Disease	renal cell carcinoma (implicated_via_orthology)	TSC2 FLCN	1.56e-04	6	96	2	DOID:4450 (implicated_via_orthology)
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	1.56e-04	6	96	2	EFO_0800106
Disease	sarcoidosis (is_marker_for)	CDKN1A HP	2.90e-04	8	96	2	DOID:11335 (is_marker_for)
Disease	hepatocellular carcinoma (is_marker_for)	TSC2 ITIH4 HP FGFR4 ALDH7A1 FOXP3	4.61e-04	301	96	6	DOID:684 (is_marker_for)
Disease	Status Dysraphicus	PDGFRA CHKA	6.77e-04	12	96	2	C0038219
Disease	Spina Bifida	PDGFRA CHKA	6.77e-04	12	96	2	C0080178
Disease	Rachischisis	PDGFRA CHKA	6.77e-04	12	96	2	C0266508
Disease	beta-hydroxyisovalerate measurement	PSMD9 ACSM2B	9.29e-04	14	96	2	EFO_0800125
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	CDKN1A ADAP2	1.55e-03	18	96	2	EFO_1000649, HP_0000131
Disease	type 1 diabetes mellitus (biomarker_via_orthology)	VWF HP	1.73e-03	19	96	2	DOID:9744 (biomarker_via_orthology)
Disease	cystathionine measurement	TEC TEC	1.73e-03	19	96	2	EFO_0010474
Disease	familial hyperlipidemia (biomarker_via_orthology)	IRF9 SLC27A1	1.73e-03	19	96	2	DOID:1168 (biomarker_via_orthology)
Disease	primary open angle glaucoma (is_implicated_in)	CDKN1A WDR36	2.53e-03	23	96	2	DOID:1070 (is_implicated_in)
Disease	insular cortex volume measurement	C2CD4A LOXHD1	2.53e-03	23	96	2	EFO_0010309
Disease	response to peginterferon alfa-2a	VWF DERA	2.99e-03	25	96	2	EFO_0010103
Disease	primary biliary cholangitis (is_marker_for)	CDKN1A FOXP3	2.99e-03	25	96	2	DOID:12236 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GDFAWERVRGLGLPK	CDKN1A	61	P38936
TKDLGRIFRWLGPKG	ALDH7A1	461	P49419
NIRGDFWLLGDRGIK	ACSM2A	436	Q08AH3
KLGSSGGWFLRVLGP	COQ3	6	Q9NZJ6
GWRGRLEIASFLPED	FGFR4	81	P22455
RGWGRPEDLKRLFEF	ABHD18	21	Q0P651
WFLLQKPGGRGALSI	AKAP13	181	Q12802
SEKPRLGGWSFGLKI	ABCA13	4361	Q86UQ4
GAGPETLEGWKATRR	DDN	421	O94850
GPWTRVLEKLGADRG	CEMIP	1301	Q8WUJ3
LKELSPGELVGWFRG	CDK5R2	201	Q13319
PGELVGWFRGVDRSL	CDK5R2	206	Q13319
LPGNREGFLWKRGRD	ADAP2	131	Q9NPF8
GLLFWDGRGEGLRLL	ITIH4	846	Q14624
LAAKGLRDPWGRNEA	NDUFB3	36	O43676
LLLTRAGLGPGDFDW	PAAT	31	Q9H8K7
LGAPWGGVAKTLRVL	PLA2G15	226	Q8NCC3
FKLLERWSGGPGLRE	ARHGEF17	16	Q96PE2
WEFPRDGLVLGRVLG	PDGFRA	586	P16234
SREPGWLEGTLNGKR	ARHGAP10	761	A1A4S6
LRGLLWVSKGEGFSP	DCDC1	366	M0R2J8
GSRREPGRLALKWGT	MBD6	881	Q96DN6
PSRTVGLFLQGGKDW	GPD2	461	P43304
KAGPAWIVRRAEGLG	MAP6	241	Q96JE9
RILGGHLDAKGSFPW	HP	161	P00738
WPFLLGKVRGIIDEL	FLCN	186	Q8NFG4
WRAAPKASDLLGARG	FOXP3	26	Q9BZS1
PELAGVIKRLWRDGG	GNAI3	121	P08754
LGPRDTRVKGWFLLD	ELOVL5	16	Q9NYP7
DGLGSRPEWFLERIL	LOXHD1	1621	Q8IVV2
DKKRGDGLTWRDLFP	LOXHD1	2051	Q8IVV2
RKAAQLPWEDGRSGL	B4GALT7	6	Q9UBV7
GVALPGLERAKGWSF	CARMIL3	1156	Q8ND23
LGGPGARLFGWLKER	DCAF10	116	Q5QP82
ARLFGWLKERSLGRG	DCAF10	121	Q5QP82
WLKERSLGRGLFVDP	DCAF10	126	Q5QP82
LRLGDLVWGKLGRYP	GLYR1	6	Q49A26
PDREGWLLKLGGGRV	CYTH1	261	Q15438
ERAAPRVLFGEWLLG	IRF7	6	Q92985
RYLGLPGSLKWEDRG	MOGS	296	Q13724
VSWSKDGRRLGEPDG	OBSCN	141	Q5VST9
GDLKGSWPGRGLVTR	FAM189B	576	P81408
RTLEVSGLWSLPGGK	CCDC149	281	Q6ZUS6
DDGLLRGWDTRVPGK	DPH7	216	Q9BTV6
RLLALKGRGWGEGDF	EPM2AIP1	106	Q7L775
KEFLPGAWRGLREDE	CHKA	96	P35790
RFLKPWLGEGILLSG	CYP4F12	126	Q9HCS2
FPGGLGKDRLAEWGR	FAM120C	171	Q9NX05
WLGFLGPILRAEVGD	HEPHL1	96	Q6MZM0
GDDGRWRPEDLGRLL	HSF4	126	Q9ULV5
EGDTGGPAVWKTRLR	IRF9	71	Q00978
GKAELLGELWAGRTR	C2orf81	476	A6NN90
RGRRFKWAIELSGPG	EMC4	11	Q5J8M3
ALERTLRKPGRGWDD	METTL13	671	Q8N6R0
GDTWDFRTLLRGLPG	HPS6	246	Q86YV9
LPKGGDWRADLGEIS	C4orf54	966	D6RIA3
LGDEWLKPELFRIGA	DERA	276	Q9Y315
EGLGLRDLWKPGIEL	SEC14L6	156	B5MCN3
RSGDWLLPGRARGAK	C2CD4A	16	Q8NCU7
GALSDVWGRKPFLLG	MFSD14C	101	Q5VZR4
GALSDVWGRKPFLLG	MFSD14B	101	Q5SR56
GRLDFKRLDRPVVGW	DHRS13	176	Q6UX07
PKGRRLSGEERGLWS	MPHOSPH8	386	Q99549
LGLWRKSPAFPGELA	FAM181A	301	Q8N9Y4
EGGEGFVVKLRGLPW	HNRNPF	6	P52597
LRLVPTRWAGKGLLG	PSMD9	201	O00233
FPDKLLGRDRQFWLG	RXFP3	251	Q9NSD7
SEGEGEGPLLRWLKV	ATP6V1C2	316	Q8NEY4
LLAGALWSPGLAKRR	PLEKHH3	586	Q7Z736
EPLGFWDALGRRDRK	SVIL	1971	O95425
LGSGLFGVVRLGKWR	TEC	376	P42680
PDGLLEFAKRLERWG	LRRC41	746	Q15345
WDPGLTARDLLFRGG	TAF1C	76	Q15572
KGDWARLLRPTLQFG	PLPP1	191	O14494
RRDVLGAFLLWPELG	SH2D5	311	Q6ZV89
GKFRGRPVSLWELLF	EPPK1	501	P58107
GDRPAEEWLGRAGLR	SFT2D3	36	Q587I9
WGLRTLEFIPKGRFV	SETMAR	151	Q53H47
RSAKWRPGGIEARGE	CCDC59	6	Q9P031
RFLSALGGLWEPGEL	SGCA	156	Q16586
DLLGLLRAPGEGVWA	TRIOBP	1561	Q9H2D6
SLFRVLGELWPLFGG	ABCD3	481	P28288
NIRGDFWLLGDRGIK	ACSM2B	436	Q68CK6
GPEFWGLSLINSGKR	ZSCAN20	271	P17040
DWDGRGRLLVKLSPV	VWF	501	P04275
EALPVGRGRVGLWKD	SULT4A1	241	Q9BR01
REEGPRGLFRGAWAL	SLC25A45	156	Q8N413
EGRPEFVGLWLGLAK	SLC27A1	136	Q6PCB7
IEGGTWRLLREKAGF	KBTBD13	416	C9JR72
WRLLREKAGFPRPGS	KBTBD13	421	C9JR72
GSRWGEDGARLLLLP	PHLDA1	106	Q8WV24
PAADSRWGGLDLRRK	SCAF1	471	Q9H7N4
PESGWDRLRELFGKD	TIMMDC1	51	Q9NPL8
LEVEWELRGGPGGRS	TAPBP	326	O15533
RAGDWFKEELRLLGG	WAPL	806	Q7Z5K2
PSQGLWLLGLREGKI	TRIM72	376	Q6ZMU5
EDPRKGIWLEAGRTL	TLN2	56	Q9Y4G6
LLVLKWGGELTPAGR	PPIP5K2	506	O43314
FGVPGGTLRGWLKDE	TIGD5	81	Q53EQ6
PKLRWFLEQLGGEVG	TIGD5	96	Q53EQ6
PVGEFLLAGGRTKTW	TSC2	1046	P49815
GWPRGLFRLGKALMG	TTC31	371	Q49AM3
RLASRSGEEGWLKPA	ZNF669	6	Q96BR6
ALRIWIFDGPTGEGR	WDR36	356	Q8NI36
LLSGEEGRRPDVLWK	ZAN	136	Q9Y493
LWVRGGRILDPEKLF	AMDHD2	31	Q9Y303