Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNG1 ATP11B SLCO4C1 NALCN SCN8A ABCC11 SLC26A9 CATSPER3 GRIN2C KCNG3 MFSD4B SLCO6A1 DISP1 SLC4A2	1.60e-06	1180	53	14	GO:0022857
GeneOntologyMolecularFunction	transporter activity	CACNG1 ATP11B SLCO4C1 NALCN SCN8A ABCC11 SLC26A9 CATSPER3 GRIN2C KCNG3 MFSD4B SLCO6A1 DISP1 SLC4A2	4.52e-06	1289	53	14	GO:0005215
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2L2 FZD9 QRFPR OR2L8 NPY2R PTPRD PTPRF OR4N4 MC3R TAS1R2 TACR1 GRIN2C GRM4 GPR176	7.90e-06	1353	53	14	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2L2 FZD9 QRFPR OR2L8 NPY2R OR4N4 MC3R TAS1R2 TACR1 GRM4 GPR176	1.66e-05	884	53	11	GO:0004930
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLCO4C1 ABCC11 SLC26A9 GRIN2C SLCO6A1 SLC4A2	1.22e-04	293	53	6	GO:0008514
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNG1 NALCN SCN8A ABCC11 SLC26A9 CATSPER3 GRIN2C KCNG3 SLC4A2	1.55e-04	758	53	9	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNG1 NALCN SCN8A SLC26A9 CATSPER3 GRIN2C KCNG3	2.00e-04	459	53	7	GO:0005216
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNG1 ATP11B NALCN SCN8A SLC26A9 CATSPER3 GRIN2C KCNG3 SLC4A2	2.17e-04	793	53	9	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNG1 NALCN SCN8A CATSPER3 GRIN2C KCNG3	2.86e-04	343	53	6	GO:0005261
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	QRFPR NPY2R	3.74e-04	11	53	2	GO:0004983
GeneOntologyMolecularFunction	neuropeptide receptor activity	QRFPR NPY2R TACR1	3.77e-04	53	53	3	GO:0008188
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	QRFPR NPY2R MC3R TACR1	4.28e-04	133	53	4	GO:0008528
GeneOntologyMolecularFunction	channel activity	CACNG1 NALCN SCN8A SLC26A9 CATSPER3 GRIN2C KCNG3	4.51e-04	525	53	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNG1 NALCN SCN8A SLC26A9 CATSPER3 GRIN2C KCNG3	4.56e-04	526	53	7	GO:0022803
GeneOntologyMolecularFunction	peptide receptor activity	QRFPR NPY2R MC3R TACR1	5.19e-04	140	53	4	GO:0001653
GeneOntologyMolecularFunction	chloride:bicarbonate antiporter activity	SLC26A9 SLC4A2	5.29e-04	13	53	2	GO:0140900
GeneOntologyMolecularFunction	bicarbonate:monoatomic anion antiporter activity	SLC26A9 SLC4A2	5.29e-04	13	53	2	GO:0140829
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine phosphatase activity	PTPRD PTPRF	9.16e-04	17	53	2	GO:0005001
GeneOntologyMolecularFunction	transmembrane receptor protein phosphatase activity	PTPRD PTPRF	9.16e-04	17	53	2	GO:0019198
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH6 DNAH14	1.03e-03	18	53	2	GO:0008569
GeneOntologyMolecularFunction	sodium-independent organic anion transmembrane transporter activity	SLCO4C1 SLCO6A1	1.03e-03	18	53	2	GO:0015347
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLCO4C1 SLC26A9 MFSD4B SLCO6A1 SLC4A2	1.11e-03	296	53	5	GO:0015291
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNG1 CATSPER3 GRIN2C KCNG3	1.38e-03	182	53	4	GO:0005244
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNG1 NALCN SCN8A CATSPER3 GRIN2C KCNG3	1.40e-03	465	53	6	GO:0046873
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNG1 CATSPER3 GRIN2C KCNG3	1.44e-03	184	53	4	GO:0022832
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLCO4C1 ABCC11 SLC26A9 MFSD4B SLCO6A1 SLC4A2	1.60e-03	477	53	6	GO:0022804
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	NALCN SCN8A	2.16e-03	26	53	2	GO:0005248
GeneOntologyMolecularFunction	glutamate receptor activity	GRIN2C GRM4	2.33e-03	27	53	2	GO:0008066
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH6 DNAH14	2.50e-03	28	53	2	GO:0051959
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC26A9 SLC4A2	3.26e-03	32	53	2	GO:0015106
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC26A9 SLC4A2	3.26e-03	32	53	2	GO:0005452
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH6 DNAH14	4.34e-03	37	53	2	GO:0045505
GeneOntologyMolecularFunction	calcium channel activity	CACNG1 CATSPER3 GRIN2C	4.88e-03	129	53	3	GO:0005262
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNG1 NALCN SCN8A CATSPER3 GRIN2C KCNG3	6.14e-03	627	53	6	GO:0022890
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNG1 CATSPER3	6.64e-03	46	53	2	GO:0005245
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNG1 CATSPER3 GRIN2C	7.53e-03	151	53	3	GO:0015085
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNG1 CATSPER3 KCNG3	7.67e-03	152	53	3	GO:0022843
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNG1 NALCN SCN8A CATSPER3 GRIN2C KCNG3	8.05e-03	664	53	6	GO:0008324
GeneOntologyMolecularFunction	sodium channel activity	NALCN SCN8A	8.42e-03	52	53	2	GO:0005272
GeneOntologyBiologicalProcess	monoatomic ion transport	CACNG1 ATP11B SLCO4C1 NALCN SCN8A ABCC11 SLC26A9 CATSPER3 GRIN2C KCNG3 MFSD4B SLC4A2 GP5	2.64e-05	1374	52	13	GO:0006811
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	CACNG1 ATP11B NALCN SCN8A ABCC11 SLC26A9 CATSPER3 GRIN2C KCNG3 SLC4A2 GP5	8.56e-05	1115	52	11	GO:0034220
GeneOntologyBiologicalProcess	cell surface receptor protein tyrosine phosphatase signaling pathway	PTPRD PTPRF	1.30e-04	7	52	2	GO:0007185
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2L2 FZD9 QRFPR OR2L8 NPY2R OR4N4 MC3R TAS1R2 TACR1 CCL23 GRM4 GPR176	1.43e-04	1395	52	12	GO:0007186
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNG1 NALCN SCN8A CATSPER3 GRIN2C KCNG3 SLCO6A1	4.51e-05	378	53	7	GO:0034702
GeneOntologyCellularComponent	transporter complex	CACNG1 ATP11B NALCN SCN8A CATSPER3 GRIN2C KCNG3 SLCO6A1	6.82e-05	550	53	8	GO:1990351
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNG1 CATSPER3 SLCO6A1	2.16e-04	46	53	3	GO:0005891
GeneOntologyCellularComponent	cation channel complex	CACNG1 SCN8A CATSPER3 KCNG3 SLCO6A1	3.18e-04	235	53	5	GO:0034703
GeneOntologyCellularComponent	transmembrane transporter complex	CACNG1 NALCN SCN8A CATSPER3 GRIN2C KCNG3 SLCO6A1	3.35e-04	523	53	7	GO:1902495
GeneOntologyCellularComponent	CatSper complex	CATSPER3 SLCO6A1	6.48e-04	15	53	2	GO:0036128
GeneOntologyCellularComponent	postsynaptic density membrane	PTPRF SCN8A CLSTN2 GRIN2C	6.73e-04	157	53	4	GO:0098839
GeneOntologyCellularComponent	calcium channel complex	CACNG1 CATSPER3 SLCO6A1	8.44e-04	73	53	3	GO:0034704
GeneOntologyCellularComponent	postsynaptic specialization membrane	PTPRF SCN8A CLSTN2 GRIN2C	1.68e-03	201	53	4	GO:0099634
GeneOntologyCellularComponent	neuron to neuron synapse	PTPRD PTPRF SCN8A CLSTN2 GRIN2C GRM4	2.02e-03	523	53	6	GO:0098984
GeneOntologyCellularComponent	motile cilium	CATSPER3 TACR1 SLCO6A1 DNAH6 DNAH14	2.02e-03	355	53	5	GO:0031514
GeneOntologyCellularComponent	excitatory synapse	PTPRF SCN8A GRM4	2.54e-03	107	53	3	GO:0060076
GeneOntologyCellularComponent	synaptic membrane	PTPRD PTPRF SCN8A CLSTN2 GRIN2C GRM4	3.46e-03	583	53	6	GO:0097060
GeneOntologyCellularComponent	plasma membrane protein complex	CACNG1 SCN8A CATSPER3 GRIN2C KCNG3 SLCO6A1 GP5	3.51e-03	785	53	7	GO:0098797
Domain	-	GTF2IRD2B GTF2IRD2	4.72e-05	4	53	2	3.90.1460.10
Domain	GTF2I	GTF2IRD2B GTF2IRD2	4.72e-05	4	53	2	IPR004212
Domain	GTF2I	GTF2IRD2B GTF2IRD2	4.72e-05	4	53	2	PS51139
Domain	GTF2I	GTF2IRD2B GTF2IRD2	4.72e-05	4	53	2	PF02946
Domain	ANF_receptor	TAS1R2 GRIN2C GRM4	1.57e-04	37	53	3	PF01094
Domain	ANF_lig-bd_rcpt	TAS1R2 GRIN2C GRM4	1.57e-04	37	53	3	IPR001828
Domain	Peripla_BP_I	TAS1R2 GRIN2C GRM4	1.83e-04	39	53	3	IPR028082
Domain	NPY_rcpt	QRFPR NPY2R	2.81e-04	9	53	2	IPR000611
Domain	Ion_trans_dom	NALCN SCN8A CATSPER3 KCNG3	3.06e-04	114	53	4	IPR005821
Domain	Ion_trans	NALCN SCN8A CATSPER3 KCNG3	3.06e-04	114	53	4	PF00520
Domain	OA_transporter	SLCO4C1 SLCO6A1	5.12e-04	12	53	2	IPR004156
Domain	OATP	SLCO4C1 SLCO6A1	5.12e-04	12	53	2	PF03137
Domain	GPCR_Rhodpsn_7TM	OR2L2 QRFPR OR2L8 NPY2R OR4N4 MC3R TACR1 GPR176	5.59e-04	670	53	8	IPR017452
Domain	Channel_four-helix_dom	NALCN SCN8A KCNG3	5.67e-04	57	53	3	IPR027359
Domain	-	NALCN SCN8A KCNG3	5.67e-04	57	53	3	1.20.120.350
Domain	7tm_1	OR2L2 QRFPR OR2L8 NPY2R OR4N4 MC3R TACR1 GPR176	5.99e-04	677	53	8	PF00001
Domain	NCD3G	TAS1R2 GRM4	6.04e-04	13	53	2	PF07562
Domain	GPCR_3_9-Cys_dom	TAS1R2 GRM4	6.04e-04	13	53	2	IPR011500
Domain	G_PROTEIN_RECEP_F1_1	OR2L2 QRFPR OR2L8 NPY2R OR4N4 MC3R TACR1 GPR176	6.47e-04	685	53	8	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2L2 QRFPR OR2L8 NPY2R OR4N4 MC3R TACR1 GPR176	6.85e-04	691	53	8	PS50262
Domain	GPCR_Rhodpsn	OR2L2 QRFPR OR2L8 NPY2R OR4N4 MC3R TACR1 GPR176	6.92e-04	692	53	8	IPR000276
Domain	Dynein_heavy_chain_D4_dom	DNAH6 DNAH14	7.03e-04	14	53	2	IPR024317
Domain	Dynein_HC_stalk	DNAH6 DNAH14	7.03e-04	14	53	2	IPR024743
Domain	GPCR_3_CS	TAS1R2 GRM4	7.03e-04	14	53	2	IPR017979
Domain	MT	DNAH6 DNAH14	7.03e-04	14	53	2	PF12777
Domain	AAA_8	DNAH6 DNAH14	7.03e-04	14	53	2	PF12780
Domain	DHC_fam	DNAH6 DNAH14	8.10e-04	15	53	2	IPR026983
Domain	Dynein_heavy_dom	DNAH6 DNAH14	8.10e-04	15	53	2	IPR004273
Domain	Dynein_heavy	DNAH6 DNAH14	8.10e-04	15	53	2	PF03028
Domain	GPCR_3	TAS1R2 GRM4	1.60e-03	21	53	2	IPR000337
Domain	G_PROTEIN_RECEP_F3_4	TAS1R2 GRM4	1.76e-03	22	53	2	PS50259
Domain	7tm_3	TAS1R2 GRM4	1.76e-03	22	53	2	PF00003
Domain	GPCR_3_C	TAS1R2 GRM4	1.76e-03	22	53	2	IPR017978
Domain	G_PROTEIN_RECEP_F3_2	TAS1R2 GRM4	1.76e-03	22	53	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	TAS1R2 GRM4	1.76e-03	22	53	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	TAS1R2 GRM4	1.76e-03	22	53	2	PS00979
Domain	PTPc	PTPRD PTPRF	4.68e-03	36	53	2	SM00194
Domain	Kazal_2	SLCO4C1 SLCO6A1	4.68e-03	36	53	2	PF07648
Domain	TYR_PHOSPHATASE_PTP	PTPRD PTPRF	5.47e-03	39	53	2	PS50055
Domain	PTPase_domain	PTPRD PTPRF	6.04e-03	41	53	2	IPR000242
Domain	Y_phosphatase	PTPRD PTPRF	6.04e-03	41	53	2	PF00102
Domain	MFS_dom	SLCO4C1 MFSD4B SLCO6A1	6.51e-03	134	53	3	IPR020846
Domain	KAZAL_2	SLCO4C1 SLCO6A1	8.87e-03	50	53	2	PS51465
Domain	Kazal_dom	SLCO4C1 SLCO6A1	9.22e-03	51	53	2	IPR002350
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	PTPRD PTPRF GRIN2C	2.16e-05	20	39	3	MM15485
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	PTPRD PTPRF GRIN2C	2.52e-05	21	39	3	M27736
Pathway	REACTOME_GPCR_LIGAND_BINDING	FZD9 QRFPR NPY2R MC3R TAS1R2 TACR1 CCL23 GRM4	3.20e-05	463	39	8	M507
Pathway	WP_GPCRS_NONODORANT	FZD9 QRFPR NPY2R MC3R TACR1 GRM4	8.25e-05	266	39	6	MM15843
Pathway	REACTOME_SIGNALING_BY_GPCR	FZD9 QRFPR NPY2R MC3R TAS1R2 TACR1 CCL23 GRM4 GPR176	9.86e-05	702	39	9	M746
Pathway	REACTOME_GPCR_LIGAND_BINDING	QRFPR NPY2R MC3R TAS1R2 TACR1 CCL23 GRM4	1.55e-04	430	39	7	MM15160
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	QRFPR NPY2R MC3R TACR1 CCL23	1.98e-04	197	39	5	M12289
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	QRFPR NPY2R MC3R TACR1 CCL23	1.98e-04	197	39	5	MM14970
Pathway	REACTOME_SIGNALING_BY_GPCR	QRFPR NPY2R MC3R TAS1R2 TACR1 CCL23 GRM4 GPR176	3.24e-04	646	39	8	MM14962
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ATP11B SLCO4C1 NALCN ABCC11 SLC26A9 MFSD4B UNC79 SLC4A2	7.73e-04	736	39	8	M27287
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	PTPRD PTPRF GRIN2C	8.30e-04	67	39	3	MM15327
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	NPY2R MC3R TACR1 GRIN2C GRM4	8.68e-04	272	39	5	M13380
Pathway	WP_GPCRS_PEPTIDE	NPY2R MC3R TACR1	9.43e-04	70	39	3	MM15959
Pathway	WP_PEPTIDE_GPCRS	NPY2R MC3R TACR1	1.15e-03	75	39	3	M39696
Pathway	REACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES	PTPRD PTPRF	1.37e-03	20	39	2	M27290
Pathway	REACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES	PTPRD PTPRF	1.37e-03	20	39	2	MM14991
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	PTPRD PTPRF GRIN2C	1.77e-03	87	39	3	M27617
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	QRFPR NPY2R MC3R TACR1 CCL23	2.04e-03	330	39	5	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	QRFPR NPY2R MC3R TACR1 CCL23	2.13e-03	333	39	5	MM14963
Pubmed	The mouse gene Ptprf encoding the leukocyte common antigen-related molecule LAR: cloning, characterization, and chromosomal localization.	PTPRD PTPRF	2.37e-06	2	54	2	7665159
Pubmed	Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	2.37e-06	2	54	2	15388857
Pubmed	Mutations in UNC80, Encoding Part of the UNC79-UNC80-NALCN Channel Complex, Cause Autosomal-Recessive Severe Infantile Encephalopathy.	NALCN UNC79	7.09e-06	3	54	2	26708753
Pubmed	Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.	GTF2IRD2B GTF2IRD2	7.09e-06	3	54	2	15100712
Pubmed	Alterations in SLC4A2, SLC26A7 and SLC26A9 Drive Acid-Base Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel Mechanism for a Co-Occurring Polyautoimmune Scenario.	SLC26A9 SLC4A2	7.09e-06	3	54	2	34944008
Pubmed	Genetic variants in components of the NALCN-UNC80-UNC79 ion channel complex cause a broad clinical phenotype (NALCN channelopathies).	NALCN UNC79	7.09e-06	3	54	2	30167850
Pubmed	LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.	PTPRD PTPRF	7.09e-06	3	54	2	31985401
Pubmed	Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.	PTPRD PTPRF	7.09e-06	3	54	2	20139422
Pubmed	Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPσ and Modulation of the Rho/ROCK Pathway.	PTPRD PTPRF	7.09e-06	3	54	2	25703008
Pubmed	Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouse.	PTPRD PTPRF	7.09e-06	3	54	2	9784606
Pubmed	Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.	PTPRD PTPRF	7.09e-06	3	54	2	33656439
Pubmed	Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.	NALCN UNC79	7.09e-06	3	54	2	21040849
Pubmed	Variation in Cilia Protein Genes and Progression of Lung Disease in Cystic Fibrosis.	DNAH6 DNAH14	7.09e-06	3	54	2	29323929
Pubmed	Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.	NALCN UNC79	7.09e-06	3	54	2	32620897
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	NPY2R TACR1 GRIN2C GRM4	7.90e-06	81	54	4	22723691
Pubmed	The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.	PTPRD PTPRF	1.42e-05	4	54	2	8524829
Pubmed	Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.	GTF2IRD2B GTF2IRD2	1.42e-05	4	54	2	21328569
Pubmed	Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression.	GRIN2C GRM4	1.42e-05	4	54	2	24925192
Pubmed	TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.	GTF2IRD2B GTF2IRD2	1.42e-05	4	54	2	17823943
Pubmed	Evolution of general transcription factors.	GTF2IRD2B GTF2IRD2	1.42e-05	4	54	2	23229069
Pubmed	GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.	GTF2IRD2B GTF2IRD2	1.42e-05	4	54	2	22899722
Pubmed	The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium.	NALCN UNC79	1.42e-05	4	54	2	32494638
Pubmed	Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.	PTPRD PTPRF	2.36e-05	5	54	2	22357843
Pubmed	Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands.	NPY2R TAS1R2	2.36e-05	5	54	2	18003792
Pubmed	Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs.	PTPRD PTPRF	2.36e-05	5	54	2	10777529
Pubmed	Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases.	PTPRD PTPRF	3.54e-05	6	54	2	19273906
Pubmed	Modulation of apoptotic response by LAR family phosphatases-cIAP1 signaling during urinary tract morphogenesis.	PTPRD PTPRF	4.94e-05	7	54	2	29073098
Pubmed	Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.	PTPRD PTPRF	4.94e-05	7	54	2	12376545
Pubmed	Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia.	QRFPR NPY2R	4.94e-05	7	54	2	24316073
Pubmed	Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.	PTPRD PTPRF	6.59e-05	8	54	2	28637841
Pubmed	Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.	PTPRD PTPRF	6.59e-05	8	54	2	37591863
Pubmed	Atlas of gene expression in the developing kidney at microanatomic resolution.	NPY2R SLCO4C1 DISP1	8.30e-05	54	54	3	19000842
Pubmed	The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.	TAS1R2 GRM4	1.06e-04	10	54	2	17156446
Pubmed	PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.	PTPRD PTPRF	1.29e-04	11	54	2	25624497
Pubmed	A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.	PTPRD PTPRF	1.29e-04	11	54	2	7832766
Pubmed	Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.	PTPRD PTPRF	1.55e-04	12	54	2	9624153
Pubmed	Structure of a mammalian sperm cation channel complex.	CATSPER3 SLCO6A1	1.83e-04	13	54	2	34225353
Pubmed	Association study of 182 candidate genes in anorexia nervosa.	NPY2R MC3R TAS1R2 TACR1	1.87e-04	182	54	4	20468064
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	QRFPR GRM4 GPR176	2.57e-04	79	54	3	12679517
Pubmed	Protein tyrosine phosphatases expression during development of mouse superior colliculus.	PTPRD PTPRF	3.17e-04	17	54	2	19727691
Pubmed	Transcriptional fates of human-specific segmental duplications in brain.	GTF2IRD2B GTF2IRD2	3.98e-04	19	54	2	30228200
Pubmed	Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos.	SLCO4C1 FGA	6.39e-04	24	54	2	21305474
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIN2C GRM4	6.39e-04	24	54	2	35746896
Pubmed	Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.	PTPRD PTPRF	7.51e-04	26	54	2	36178190
Pubmed	A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.	PTPRD CLSTN2	1.14e-03	32	54	2	23049088
Pubmed	The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.	SCN8A CAMTA1	1.21e-03	33	54	2	22357600
Pubmed	Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.	SPPL2A FGA	1.36e-03	35	54	2	23969696
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	DIP2C CDYL2 CAMTA1	1.42e-03	142	54	3	19851296
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	DIP2C CDYL2 CAMTA1	1.45e-03	143	54	3	20198315
Pubmed	Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.	NPY2R FGA	1.52e-03	37	54	2	16707424
Cytoband	7q11.23	FZD9 GTF2IRD2B GTF2IRD2	2.10e-04	97	54	3	7q11.23
GeneFamily	Dyneins, axonemal	DNAH6 DNAH14	6.36e-04	17	40	2	536
GeneFamily	Cadherin related	CDHR2 CLSTN2	6.36e-04	17	40	2	24
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRD PTPRF	9.76e-04	21	40	2	813
GeneFamily	Solute carriers	SLCO4C1 SLC26A9 SLCO6A1 SLC4A2 SLC35F5	1.70e-03	395	40	5	752
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	QRFPR SLCO4C1 KCNG3 DNAH6	2.42e-05	144	52	4	08005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TACR1 UNC79 GPR176 FAM162A	2.55e-05	146	52	4	86cddd0e7f954547b7ffdccb0329cd5c4b725ac1
ToppCell	P15-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	NPY2R PTPRF SLCO4C1 SLC26A9	3.56e-05	159	52	4	a4bfd59c53237964fc24a24de5c1925fdd01db99
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L5_RORB_SNHG7\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPY2R CLSTN2 DNAH6 DNAH14	3.93e-05	163	52	4	6ed2a71385e85508ed513282c06440add7cc010c
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPPL2A CDHR2 FAM162A SLC35F5	4.12e-05	165	52	4	ce79d217df88035457cd58f679e72dd98722ae22
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPY2R NALCN UNC79 GPR176	4.52e-05	169	52	4	606aa4ff25380d9470ec116ca86cd20f8b19587a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NPY2R NALCN UNC79 GPR176	4.52e-05	169	52	4	052aae2af5446a0de071d5dda5381b0b9a0ed54d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPY2R CLSTN2 DNAH6 DNAH14	4.73e-05	171	52	4	9e00c8191ca9d52151a49baf39f8581cb176fb76
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPY2R CLSTN2 DNAH6 DNAH14	4.84e-05	172	52	4	92e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	NPY2R SLCO4C1 TACR1 CAMTA1	4.95e-05	173	52	4	7e3897868dd3f6e4974f593c60649a543ffc8693
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NPY2R CLSTN2 DNAH6 DNAH14	5.06e-05	174	52	4	2947e5906b172d149412fa4e77476fce4ea695d2
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PTPRD SLCO4C1 SLC26A9 DNAH14	7.41e-05	192	52	4	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP31 ITPRIP TACR1 GPR176	7.56e-05	193	52	4	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_venous\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SACS ARHGAP31 TACR1 CCL23	8.51e-05	199	52	4	d359f3e1595ba8d8a3dc9eb2e8f2b61f3247c7a1
Disease	unipolar depression, mood disorder, response to antidepressant	PTPRD SCN8A	2.63e-04	14	51	2	EFO_0003761, EFO_0004247, GO_0036276
Disease	Attention Deficit Disorder	PTPRD TACR1	6.62e-04	22	51	2	C0041671
Disease	Minimal Brain Dysfunction	PTPRD TACR1	6.62e-04	22	51	2	C1321905
Disease	Epilepsy, Benign Psychomotor, Childhood	NPY2R GRM4	7.24e-04	23	51	2	C0393672
Disease	Epilepsy, Lateral Temporal	NPY2R GRM4	7.24e-04	23	51	2	C0393682
Disease	Uncinate Epilepsy	NPY2R GRM4	7.24e-04	23	51	2	C0014558
Disease	Epilepsy, Temporal Lobe	NPY2R GRM4	7.24e-04	23	51	2	C0014556
Disease	Attention deficit hyperactivity disorder	PTPRD TACR1	7.89e-04	24	51	2	C1263846
Disease	azoospermia (implicated_via_orthology)	PTPRD PTPRF	1.00e-03	27	51	2	DOID:14227 (implicated_via_orthology)
Disease	Strabismus	PTPRD ABCC11	1.15e-03	29	51	2	HP_0000486
Disease	blood viscosity	PTPRD PTPRF	1.32e-03	31	51	2	EFO_0004301
Disease	puberty onset measurement	MC3R CAMTA1 UNC79	1.33e-03	125	51	3	EFO_0005677
Disease	cannabis dependence	PTPRD PTPRF MFSD4B	1.66e-03	135	51	3	EFO_0007191
Disease	Alcohol Use Disorder	NPY2R TACR1	2.65e-03	44	51	2	C0001956
Disease	eosinophilic esophagitis	SPPL2A PTPRD RAD50	2.84e-03	163	51	3	EFO_0004232
Disease	migraine disorder	PTPRD DIP2C CAMTA1 MFSD4B	3.36e-03	357	51	4	MONDO_0005277
Disease	urate measurement, bone density	PTPRD CATSPER3 GRIN2C SNX19 DNAH14	4.24e-03	619	51	5	EFO_0003923, EFO_0004531
Disease	Withdrawal Symptoms	NPY2R TACR1	4.55e-03	58	51	2	C0087169
Disease	Drug Withdrawal Symptoms	NPY2R TACR1	4.55e-03	58	51	2	C0086189
Disease	Substance Withdrawal Syndrome	NPY2R TACR1	4.55e-03	58	51	2	C0038587

Protein segments in the cluster

Peptide	Gene	Start	Entry
MVVLTRIFTDREMKC	SLC4A2	1201	P04920
MKVSVAALSCLMLVT	CCL23	1	P55773
SRVVVVCEKMMSRAC	CAMTA1	1036	Q9Y6Y1
VIMSRFFKIIMISTV	CATSPER3	46	Q86XQ3
MLLMVTCTVYAIKTR	GRM4	761	Q14833
VIIISVCMLVFVVAM	CLSTN2	836	Q9H4D0
IVIVLLVMCVYTKSM	DISP1	511	Q96F81
MSQTKMLKVRVTLFC	CACNG1	1	Q06432
YPIRISKRVCVMMIT	OR2L2	131	Q8NH16
AMSTCTTRVIIILLM	OR4N4C	236	A0A096LPK9
AVIMMVTVVALFAVC	QRFPR	271	Q96P65
KVCLTDVTIMERFQM	RAD50	786	Q92878
MAMGLFRVCLVVVTA	ITPRIP	1	Q8IWB1
TTKMLVCVVVVFAVS	NPY2R	266	P49146
REMVMLLVFICVAMA	KCNG3	321	Q8TAE7
ATLLSMVMVFILCSV	GPR176	266	Q14439
YLIRMSKRVCVLMIT	OR2L8	131	Q8NGY9
AMSTCTTRVIIILLM	OR4N4	236	Q8N0Y3
TAVERILQYMKMCVS	ABCC11	1106	Q96J66
FCKTAILLTVMMSIF	MFSD4B	81	Q5TF39
TVAVFMLKIFMSLVV	FZD9	506	O00144
VLVIMTMAFVCVRKS	CDHR2	1166	Q9BYE9
EIKLVMTCAAFITMN	DNAH6	1561	Q9C0G6
CMVRKVIQFYETMLV	DNAH6	1731	Q9C0G6
CTLTITLNIIMKMFV	DPY19L4	356	Q7Z388
TVKMIVEVSRSACLM	DIP2C	1071	Q9Y2E4
KEIRINMSCAVFITM	DNAH14	1226	Q0VDD8
MFSMRIVCLVLSVVG	FGA	1	P02671
VYSESKMVIVCLITM	MC3R	181	P41968
VQAMITVIIVFAMIK	GP5	531	P40197
TYMIICQISVKVTME	HEATR1	261	Q9H583
MVVTFLVSALESMCK	GTF2IRD2	21	Q86UP8
MVVTFLVSALESMCK	GTF2IRD2B	21	Q6EKJ0
VAMRVMECTACIIIK	SACS	4556	Q9NZJ4
VVMMTRLEEKSRVKC	PTPRF	1446	P10586
VVMMTKLEERSRVKC	PTPRD	1451	P23468
RFVMQVKTFSEACLM	DAP3	86	P51398
LKTRLQMVCVFVMNR	SLC35F5	41	Q8WV83
VASLCVSLVVMITML	SLC26A9	406	Q7LBE3
VVKMMIVVVCTFAIC	TACR1	246	P25103
CKALMRFIMVTSVIS	SLCO6A1	451	Q86UG4
LMIALTVVGCIFMVI	FAM162A	106	Q96A26
VMVTTVPLVCNKSMF	URB1	426	O60287
VMLRVKEMASCSAVV	CDYL2	441	Q8N8U2
MCFLSIIITTVCIIM	CLEC2A	31	Q6UVW9
FTVMVITVTVKMALE	ATP11B	1006	Q9Y2G3
HMLVAISVTCKVITM	SLCO4C1	666	Q6ZQN7
LTVVIFVVICCVMMV	SPPL2A	221	Q8TCT8
IKILIHSVFSMIIMC	SCN8A	126	Q9UQD0
VRTSFMVKMCQARAV	ARHGAP31	1186	Q2M1Z3
FMVSRIDKMVVSAIV	SNX19	671	Q92543
SMAFITVLKMVIVVI	TAS1R2	681	Q8TE23
LKTVCDVRFDVMVMC	UNC79	561	Q9P2D8
VMIIVTICSCISMMF	NALCN	891	Q8IZF0
VMCLTVVAITVFMFE	GRIN2C	561	Q14957