Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	complement component C3b binding	CFH CFHR5 CFHR3	3.82e-06	12	53	3	GO:0001851
GeneOntologyMolecularFunction	opsonin binding	CFH CFHR5 CFHR3	3.90e-05	25	53	3	GO:0001846
GeneOntologyMolecularFunction	complement binding	CFH CFHR5 CFHR3	8.29e-05	32	53	3	GO:0001848
GeneOntologyMolecularFunction	frizzled binding	WNT7B WNT9B WNT4	1.88e-04	42	53	3	GO:0005109
GeneOntologyMolecularFunction	tumor necrosis factor receptor activity	TNFRSF11A TNFRSF4	4.49e-04	12	53	2	GO:0005031
GeneOntologyMolecularFunction	transcription coregulator activity	ZMYND11 ZNF366 AEBP2 WNT4 ZXDA ZNF541 RBCK1	6.76e-04	562	53	7	GO:0003712
GeneOntologyMolecularFunction	glycosaminoglycan binding	CFH CCN6 LPA STAB1 CFHR3	7.12e-04	268	53	5	GO:0005539
GeneOntologyMolecularFunction	signaling receptor regulator activity	CCN6 WNT7B PDGFD WNT9B WNT4 IGSF1 TAFA2	1.16e-03	616	53	7	GO:0030545
GeneOntologyMolecularFunction	death receptor activity	TNFRSF11A TNFRSF4	1.41e-03	21	53	2	GO:0005035
GeneOntologyMolecularFunction	heparin binding	CFH CCN6 LPA CFHR3	1.68e-03	192	53	4	GO:0008201
GeneOntologyBiologicalProcess	metanephric tubule development	WNT7B WNT9B WNT4	3.77e-05	26	52	3	GO:0072170
GeneOntologyBiologicalProcess	kidney development	CFH OVOL1 WNT7B PDGFD WNT9B WNT4 SMAD2	3.90e-05	372	52	7	GO:0001822
GeneOntologyBiologicalProcess	metanephric epithelium development	WNT7B WNT9B WNT4	4.74e-05	28	52	3	GO:0072207
GeneOntologyBiologicalProcess	renal system development	CFH OVOL1 WNT7B PDGFD WNT9B WNT4 SMAD2	4.93e-05	386	52	7	GO:0072001
GeneOntologyBiologicalProcess	metanephros morphogenesis	WNT7B WNT9B WNT4	5.27e-05	29	52	3	GO:0003338
GeneOntologyBiologicalProcess	nephron development	CFH WNT7B PDGFD WNT9B WNT4	7.61e-05	174	52	5	GO:0072006
GeneOntologyBiologicalProcess	metanephric tubule formation	WNT9B WNT4	9.29e-05	6	52	2	GO:0072174
GeneOntologyBiologicalProcess	smooth muscle cell differentiation	PROK2 CFH WNT7B WNT4	1.13e-04	99	52	4	GO:0051145
GeneOntologyBiologicalProcess	metanephric tubule morphogenesis	WNT9B WNT4	2.77e-04	10	52	2	GO:0072173
GeneOntologyCellularComponent	cell surface	CFH VWF LPA WNT7B UNC5C BTLA TNFRSF11A WNT4 LY9 GRM7 VWDE TNFRSF4	1.68e-05	1111	53	12	GO:0009986
GeneOntologyCellularComponent	external side of plasma membrane	CFH VWF LPA BTLA TNFRSF11A LY9 TNFRSF4	3.20e-04	519	53	7	GO:0009897
Domain	Sushi	CFH CFHR5 CSMD3 F13B CFHR3	3.23e-07	52	52	5	PF00084
Domain	CCP	CFH CFHR5 CSMD3 F13B CFHR3	3.92e-07	54	52	5	SM00032
Domain	SUSHI	CFH CFHR5 CSMD3 F13B CFHR3	4.71e-07	56	52	5	PS50923
Domain	Sushi_SCR_CCP_dom	CFH CFHR5 CSMD3 F13B CFHR3	5.15e-07	57	52	5	IPR000436
Domain	VWD	VWF MUC5B VWDE	1.11e-05	16	52	3	SM00216
Domain	VWF_type-D	VWF MUC5B VWDE	1.11e-05	16	52	3	IPR001846
Domain	VWFD	VWF MUC5B VWDE	1.11e-05	16	52	3	PS51233
Domain	VWD	VWF MUC5B VWDE	1.11e-05	16	52	3	PF00094
Domain	CTCK_1	CCN6 VWF MUC5B	1.61e-05	18	52	3	PS01185
Domain	Wnt	WNT7B WNT9B WNT4	1.91e-05	19	52	3	IPR005817
Domain	Wnt_CS	WNT7B WNT9B WNT4	1.91e-05	19	52	3	IPR018161
Domain	wnt	WNT7B WNT9B WNT4	1.91e-05	19	52	3	PF00110
Domain	WNT1	WNT7B WNT9B WNT4	1.91e-05	19	52	3	SM00097
Domain	WNT1	WNT7B WNT9B WNT4	1.91e-05	19	52	3	PS00246
Domain	CT	CCN6 VWF MUC5B	3.02e-05	22	52	3	SM00041
Domain	Cys_knot_C	CCN6 VWF MUC5B	4.48e-05	25	52	3	IPR006207
Domain	CTCK_2	CCN6 VWF MUC5B	4.48e-05	25	52	3	PS01225
Domain	CUB	PDGFD TMPRSS7 CSMD3	3.43e-04	49	52	3	PF00431
Domain	CUB	PDGFD TMPRSS7 CSMD3	3.64e-04	50	52	3	SM00042
Domain	-	PDGFD TMPRSS7 CSMD3	4.09e-04	52	52	3	2.60.120.290
Domain	zf-RING_2	PJA2 PJA1 RFWD3	4.09e-04	52	52	3	PF13639
Domain	CUB	PDGFD TMPRSS7 CSMD3	4.32e-04	53	52	3	PS01180
Domain	TIL	VWF MUC5B	4.93e-04	12	52	2	PF01826
Domain	C8	VWF MUC5B	4.93e-04	12	52	2	PF08742
Domain	CUB_dom	PDGFD TMPRSS7 CSMD3	5.36e-04	57	52	3	IPR000859
Domain	Unchr_dom_Cys-rich	VWF MUC5B	5.82e-04	13	52	2	IPR014853
Domain	C8	VWF MUC5B	5.82e-04	13	52	2	SM00832
Domain	TIL_dom	VWF MUC5B	6.77e-04	14	52	2	IPR002919
Domain	TSP_1	CCN6 UNC5C ADAMTS17	7.18e-04	63	52	3	PF00090
Domain	Glyco_hormone_CN	CCN6 MUC5B	7.80e-04	15	52	2	IPR006208
Domain	Cys_knot	CCN6 MUC5B	7.80e-04	15	52	2	PF00007
Domain	TSP1	CCN6 UNC5C ADAMTS17	7.87e-04	65	52	3	SM00209
Domain	TSP1_rpt	CCN6 UNC5C ADAMTS17	7.87e-04	65	52	3	IPR000884
Domain	TSP1	CCN6 UNC5C ADAMTS17	7.87e-04	65	52	3	PS50092
Domain	IG	IGSF22 TRIO UNC5C BTLA IGSF1 LY9	1.07e-03	421	52	6	SM00409
Domain	Ig_sub	IGSF22 TRIO UNC5C BTLA IGSF1 LY9	1.07e-03	421	52	6	IPR003599
Domain	VWC_out	VWF MUC5B	1.26e-03	19	52	2	SM00215
Domain	Znf_C3HC4_RING-type	PJA2 PJA1 RFWD3 RBCK1	1.33e-03	172	52	4	IPR018957
Domain	RING	PJA2 ZMYND11 PJA1 RFWD3 RBCK1	1.56e-03	305	52	5	SM00184
Domain	zf-RanBP	NEIL3 RBCK1	1.69e-03	22	52	2	PF00641
Domain	TNFR_c6	TNFRSF11A TNFRSF4	1.69e-03	22	52	2	PF00020
Domain	ZnF_RBZ	NEIL3 RBCK1	1.85e-03	23	52	2	SM00547
Domain	ZF_RANBP2_2	NEIL3 RBCK1	1.85e-03	23	52	2	PS50199
Domain	ZF_RANBP2_1	NEIL3 RBCK1	2.02e-03	24	52	2	PS01358
Domain	Znf_RING	PJA2 ZMYND11 PJA1 RFWD3 RBCK1	2.09e-03	326	52	5	IPR001841
Domain	Znf_RanBP2	NEIL3 RBCK1	2.19e-03	25	52	2	IPR001876
Domain	IG_LIKE	IGSF22 TRIO UNC5C BTLA IGSF1 LY9	2.34e-03	491	52	6	PS50835
Domain	TNFR	TNFRSF11A TNFRSF4	2.37e-03	26	52	2	SM00208
Domain	Ig-like_dom	IGSF22 TRIO UNC5C BTLA IGSF1 LY9	2.64e-03	503	52	6	IPR007110
Domain	VWC	VWF MUC5B	2.74e-03	28	52	2	PF00093
Domain	TNFR_NGFR_1	TNFRSF11A TNFRSF4	2.94e-03	29	52	2	PS00652
Domain	TNFR_NGFR_2	TNFRSF11A TNFRSF4	2.94e-03	29	52	2	PS50050
Domain	EGF_LAM_2	LAMA2 STAB1	3.15e-03	30	52	2	PS50027
Domain	EGF_LAM_1	LAMA2 STAB1	3.15e-03	30	52	2	PS01248
Domain	zf-C3HC4	PJA2 PJA1 RFWD3 RBCK1	3.42e-03	223	52	4	PF00097
Domain	TNFR/NGFR_Cys_rich_reg	TNFRSF11A TNFRSF4	3.80e-03	33	52	2	IPR001368
Domain	IGc2	IGSF22 TRIO UNC5C IGSF1	4.12e-03	235	52	4	SM00408
Domain	Ig_sub2	IGSF22 TRIO UNC5C IGSF1	4.12e-03	235	52	4	IPR003598
Domain	Laminin_EGF	LAMA2 STAB1	4.27e-03	35	52	2	PF00053
Domain	EGF_Lam	LAMA2 STAB1	4.27e-03	35	52	2	SM00180
Domain	VWFC_1	VWF MUC5B	4.51e-03	36	52	2	PS01208
Domain	VWC	VWF MUC5B	5.01e-03	38	52	2	SM00214
Domain	VWFC_2	VWF MUC5B	5.01e-03	38	52	2	PS50184
Domain	Laminin_EGF	LAMA2 STAB1	5.01e-03	38	52	2	IPR002049
Domain	VWF_dom	VWF MUC5B	6.10e-03	42	52	2	IPR001007
Domain	-	PJA2 ZMYND11 PJA1 RFWD3 RBCK1	8.07e-03	449	52	5	3.30.40.10
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR	CFH CFHR5 CFHR3	3.89e-07	6	39	3	M47880
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION	WNT7B WNT9B WNT4	1.84e-05	19	39	3	M47836
Pathway	WP_BLOOD_CLOTTING_CASCADE	VWF LPA F13B	3.34e-05	23	39	3	MM15936
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT7B WNT9B WNT4	4.32e-05	25	39	3	MM14940
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT7B WNT9B WNT4	4.87e-05	26	39	3	M27239
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_INHIBITOR	WNT7B WNT9B WNT4	6.11e-05	28	39	3	M47835
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT7B WNT9B WNT4	6.81e-05	29	39	3	M47372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT7B WNT9B WNT4	6.81e-05	29	39	3	M47377
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	WNT7B WNT9B WNT4	1.31e-04	36	39	3	M39699
Pathway	KEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	WNT7B WNT9B WNT4	1.43e-04	37	39	3	M47411
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	WNT7B WNT9B WNT4	2.40e-04	44	39	3	MM15878
Pathway	KEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	WNT7B WNT9B WNT4	2.56e-04	45	39	3	M47412
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY	WNT7B WNT9B WNT4	2.74e-04	46	39	3	M47409
Pathway	KEGG_BASAL_CELL_CARCINOMA	WNT7B WNT9B WNT4	4.65e-04	55	39	3	M17807
Pathway	KEGG_HEDGEHOG_SIGNALING_PATHWAY	WNT7B WNT9B WNT4	4.90e-04	56	39	3	M1053
Pathway	WP_COMPLEMENT_AND_COAGULATION_CASCADES	CFH VWF F13B	5.44e-04	58	39	3	M39649
Pathway	REACTOME_NEPHRON_DEVELOPMENT	WNT9B WNT4	5.71e-04	13	39	2	M48245
Pathway	WP_DENGUE2_INTERACTIONS_WITH_COMPLEMENT_AND_COAGULATION_CASCADES	CFH VWF F13B	5.72e-04	59	39	3	M48343
Pathway	KEGG_WNT_SIGNALING_PATHWAY	WNT7B WNT9B WNT4 SMAD2	7.77e-04	151	39	4	M19428
Pathway	PID_SMAD2_3PATHWAY	NUP214 SMAD2	8.73e-04	16	39	2	M228
Pathway	KEGG_COMPLEMENT_AND_COAGULATION_CASCADES	CFH VWF F13B	9.04e-04	69	39	3	M16894
Pathway	WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER	WNT7B WNT9B WNT4 SMAD2	9.87e-04	161	39	4	M39770
Pathway	WP_NEPHROGENESIS	WNT9B WNT4	1.11e-03	18	39	2	M40045
Pathway	REACTOME_GPCR_LIGAND_BINDING	PROK2 WNT7B WNT9B WNT4 GRM7 ECE2	1.58e-03	463	39	6	M507
Pathway	WP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY	WNT7B WNT9B WNT4	1.65e-03	85	39	3	M48315
Pathway	WP_BLOOD_CLOTTING_CASCADE	VWF F13B	1.66e-03	22	39	2	M39480
Pathway	KEGG_PATHWAYS_IN_CANCER	WNT7B WNT9B LAMA2 WNT4 SMAD2	1.91e-03	325	39	5	M12868
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	WNT7B WNT9B WNT4	2.21e-03	94	39	3	M797
Pubmed	Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.	CFH CFHR5 CFHR3	7.46e-08	6	55	3	27196323
Pubmed	The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.	CFH CFHR5 F13B	7.46e-08	6	55	3	18541031
Pubmed	Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.	CFH CFHR5 CFHR3	7.46e-08	6	55	3	17438673
Pubmed	Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.	CCN6 WNT7B WNT9B WNT4	2.83e-07	35	55	4	19185060
Pubmed	Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.	CFH CFHR5 CFHR3	3.12e-07	9	55	3	20059470
Pubmed	FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.	CFH CFHR5 CFHR3	3.12e-07	9	55	3	28533443
Pubmed	Wnt signaling in heart valve development and osteogenic gene induction.	WNT7B WNT9B WNT4	3.12e-07	9	55	3	19961844
Pubmed	Molecular genetic studies of Wnt signaling in the mouse.	WNT7B WNT9B WNT4	2.07e-06	16	55	3	10585256
Pubmed	The Wnts.	WNT7B WNT9B WNT4	2.07e-06	16	55	3	9889131
Pubmed	c-Met and NF-κB-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease.	WNT7B WNT9B WNT4	2.07e-06	16	55	3	22677559
Pubmed	The interaction between factor H and Von Willebrand factor.	CFH VWF	2.46e-06	2	55	2	23991205
Pubmed	Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease).	CFH CFHR5	2.46e-06	2	55	2	16299065
Pubmed	Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization.	EEF1AKMT4-ECE2 ECE2	2.46e-06	2	55	2	11718899
Pubmed	Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease.	CFH CFHR3	2.46e-06	2	55	2	20694013
Pubmed	Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells.	CFH CFHR3	2.46e-06	2	55	2	34819935
Pubmed	Human complement factor H is a reductase for large soluble von Willebrand factor multimers--brief report.	CFH VWF	2.46e-06	2	55	2	24008159
Pubmed	A De Novo Deletion in the Regulators of Complement Activation Cluster Producing a Hybrid Complement Factor H/Complement Factor H-Related 3 Gene in Atypical Hemolytic Uremic Syndrome.	CFH CFHR3	2.46e-06	2	55	2	26490391
Pubmed	The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status.	CFH VWF	2.46e-06	2	55	2	24014239
Pubmed	Wnt family proteins are secreted and associated with the cell surface.	WNT7B WNT9B WNT4	2.50e-06	17	55	3	8167409
Pubmed	Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia.	WNT7B WNT9B WNT4	3.00e-06	18	55	3	23704941
Pubmed	GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.	WNT7B WNT9B WNT4	3.00e-06	18	55	3	19809516
Pubmed	Genome-wide association study identifies susceptibility loci for IgA nephropathy.	CFH CFHR5 CFHR3	3.56e-06	19	55	3	21399633
Pubmed	Coronary Artery Formation Is Driven by Localized Expression of R-spondin3.	WNT7B WNT9B WNT4	3.56e-06	19	55	3	28834739
Pubmed	Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system.	WNT7B WNT9B WNT4	3.56e-06	19	55	3	16054034
Pubmed	Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.	WNT7B WNT9B WNT4	3.56e-06	19	55	3	11520664
Pubmed	The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice.	WNT7B WNT9B WNT4	4.19e-06	20	55	3	21248711
Pubmed	Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.	WNT7B WNT9B WNT4	4.88e-06	21	55	3	17943183
Pubmed	The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium.	WNT7B WNT9B WNT4	4.88e-06	21	55	3	11914369
Pubmed	Epithelial Wnt10a Is Essential for Tooth Root Furcation Morphogenesis.	WNT7B WNT9B WNT4	4.88e-06	21	55	3	31914354
Pubmed	Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGFβ signaling.	WNT9B WNT4 SMAD2	4.88e-06	21	55	3	29945868
Pubmed	Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium.	WNT7B WNT9B WNT4	5.64e-06	22	55	3	25758227
Pubmed	Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric β-catenin signaling.	WNT7B WNT9B WNT4	5.64e-06	22	55	3	25587709
Pubmed	Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration.	WNT7B WNT9B WNT4	5.64e-06	22	55	3	18991257
Pubmed	Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models.	WNT7B WNT9B WNT4	6.48e-06	23	55	3	27362799
Pubmed	Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent.	CFH CFHR3	7.36e-06	3	55	2	20581873
Pubmed	Complement factor H, FHR-3 and FHR-1 variants associate in an extended haplotype conferring increased risk of atypical hemolytic uremic syndrome.	CFH CFHR3	7.36e-06	3	55	2	26163426
Pubmed	Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes.	CFH CFHR3	7.36e-06	3	55	2	10781834
Pubmed	Association assessment of copy number polymorphism and risk of age-related macular degeneration.	CFH CFHR3	7.36e-06	3	55	2	21856016
Pubmed	Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus.	NUP214 SMAD2	7.36e-06	3	55	2	12191473
Pubmed	Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips.	WNT7B WNT4	7.36e-06	3	55	2	8951078
Pubmed	Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy.	CFH CFHR3	7.36e-06	3	55	2	25205734
Pubmed	Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency.	CFH CFHR3	7.36e-06	3	55	2	18006700
Pubmed	Atypical hemolytic uremic syndrome associated with complement factor H autoantibodies and CFHR1/CFHR3 deficiency.	CFH CFHR3	7.36e-06	3	55	2	19531976
Pubmed	PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain.	PJA2 PJA1	7.36e-06	3	55	2	12036302
Pubmed	Evaluation of CFH Y402H polymorphism and CFHR3/CFHR1 deletion in age-related macular degeneration patients from Brazil.	CFH CFHR3	7.36e-06	3	55	2	26942649
Pubmed	An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD).	CFH CFHR3	7.36e-06	3	55	2	20843825
Pubmed	Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population.	CFH CFHR3	7.36e-06	3	55	2	22848687
Pubmed	A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes.	CFH CFHR3	7.36e-06	3	55	2	32321835
Pubmed	Two factor H-related proteins from the mouse: expression analysis and functional characterization.	CFH CFHR3	7.36e-06	3	55	2	17028856
Pubmed	Localization of complement factor H gene expression and protein distribution in the mouse outer retina.	CFH CFHR3	7.36e-06	3	55	2	25684976
Pubmed	A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney.	WNT7B WNT9B WNT4	9.48e-06	26	55	3	19060336
Pubmed	Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections.	WNT7B WNT9B WNT4	1.07e-05	27	55	3	17804636
Pubmed	Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.	WNT7B WNT9B WNT4	1.19e-05	28	55	3	20940229
Pubmed	Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development.	WNT7B WNT9B WNT4	1.19e-05	28	55	3	24394376
Pubmed	Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.	WNT7B WNT9B WNT4	1.33e-05	29	55	3	22956684
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	WNT7B WNT9B WNT4	1.33e-05	29	55	3	18364260
Pubmed	Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1-3 and complement factor H 479.	CFH CFHR3	1.47e-05	4	55	2	24333077
Pubmed	Genetic susceptibility to chronic otitis media with effusion: candidate gene single nucleotide polymorphisms.	MUC5B SMAD2	1.47e-05	4	55	2	23929584
Pubmed	Canonical WNT signaling during kidney development.	WNT7B WNT4	1.47e-05	4	55	2	17494089
Pubmed	Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2/HTRA1 loci.	CFH CFHR5	1.47e-05	4	55	2	34563268
Pubmed	Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development.	WNT9B WNT4	1.47e-05	4	55	2	18682239
Pubmed	CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome.	CFH CFHR3	1.47e-05	4	55	2	36793547
Pubmed	Mutational analysis of the WNT gene family in women with Mayer-Rokitansky-Kuster-Hauser syndrome.	WNT9B WNT4	1.47e-05	4	55	2	19171330
Pubmed	Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.	WNT7B WNT9B WNT4	1.47e-05	30	55	3	19282366
Pubmed	Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract.	WNT7B WNT9B WNT4	1.47e-05	30	55	3	21936019
Pubmed	Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development.	WNT7B WNT9B WNT4	1.47e-05	30	55	3	15880404
Pubmed	Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development.	WNT7B WNT9B WNT4	1.47e-05	30	55	3	36305473
Pubmed	The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development.	WNT7B WNT4 SMAD2	1.80e-05	32	55	3	25428587
Pubmed	Early embryonic expression of murine coagulation system components.	VWF LPA F13B	2.16e-05	34	55	3	11154109
Pubmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.	WNT7B WNT9B WNT4	2.36e-05	35	55	3	30940800
Pubmed	GLI2 Modulated by SUFU and SPOP Induces Intestinal Stem Cell Niche Signals in Development and Tumorigenesis.	WNT7B WNT9B WNT4	2.36e-05	35	55	3	31167144
Pubmed	Tracing the origin of hair follicle stem cells.	WNT7B ADAMTS17 WNT4	2.36e-05	35	55	3	34108685
Pubmed	Complement factor H and related proteins: an expanding family of complement-regulatory proteins?	CFH CFHR3	2.45e-05	5	55	2	8172644
Pubmed	Factor H-related proteins determine complement-activating surfaces.	CFHR5 CFHR3	2.45e-05	5	55	2	25979655
Pubmed	Identification and sequence analysis of four complement factor H-related transcripts in mouse liver.	CFH CFHR3	2.45e-05	5	55	2	1689298
Pubmed	Increased IGF-1 in muscle modulates the phenotype of severe SMA mice.	TNFRSF11A GRM7	2.45e-05	5	55	2	21325354
Pubmed	Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import.	NUP214 SMAD2	2.45e-05	5	55	2	12917407
Pubmed	Molecular cloning of the b subunit of mouse coagulation factor XIII and assignment of the gene to chromosome 1: close evolutionary relationship to complement factor H.	CFH F13B	2.45e-05	5	55	2	8468048
Pubmed	Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4.	CFH CFHR3	2.45e-05	5	55	2	20042240
Pubmed	A radiation hybrid map of complement factor H and factor H-related genes.	CFH CFHR3	2.45e-05	5	55	2	10380701
Pubmed	Integrated analysis of Wnt signalling system component gene expression.	WNT7B WNT9B WNT4	2.80e-05	37	55	3	35831952
Pubmed	Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.	WNT7B WNT9B WNT4	3.04e-05	38	55	3	21041481
Pubmed	Tissue-specific requirements of beta-catenin in external genitalia development.	WNT7B WNT9B WNT4	3.04e-05	38	55	3	18635608
Pubmed	Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis.	WNT7B WNT9B WNT4	3.04e-05	38	55	3	23190887
Pubmed	Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors.	WNT7B WNT9B WNT4	3.28e-05	39	55	3	24586192
Pubmed	A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.	PJA2 PJA1	3.67e-05	6	55	2	11959851
Pubmed	Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling.	WNT7B WNT4	3.67e-05	6	55	2	14671310
Pubmed	Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland.	WNT7B WNT4	3.67e-05	6	55	2	1373817
Pubmed	Dimerization of complement factor H-related proteins modulates complement activation in vivo.	CFH CFHR5	3.67e-05	6	55	2	23487775
Pubmed	Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.	WNT7B WNT4	3.67e-05	6	55	2	8168088
Pubmed	Identification of molecular determinants required for interaction of ubiquitin-conjugating enzymes and RING finger proteins.	UBE2L6 RBCK1	3.67e-05	6	55	2	11722579
Pubmed	Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development.	WNT9B WNT4	3.67e-05	6	55	2	17537789
Pubmed	Growth of geographic atrophy on fundus autofluorescence and polymorphisms of CFH, CFB, C3, FHR1-3, and ARMS2 in age-related macular degeneration.	CFH CFHR3	3.67e-05	6	55	2	24557084
Pubmed	Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement.	CFH CFHR5	3.67e-05	6	55	2	23235567
Pubmed	Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation.	LPA F13B	3.67e-05	6	55	2	31101623
Pubmed	Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells.	WNT9B WNT4	3.67e-05	6	55	2	21852398
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	PJA2 UBE2L6 PJA1 RFWD3	3.76e-05	118	55	4	19690564
Pubmed	Gpr177 regulates pulmonary vasculature development.	WNT7B WNT9B WNT4	4.73e-05	44	55	3	23884445
Pubmed	Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.	CFH CFHR5	5.13e-05	7	55	2	20513133
Pubmed	Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.	CFH CFHR3	5.13e-05	7	55	2	19861685
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFH CFHR5 F13B CFHR3	2.10e-06	75	55	4	chr1q31
Cytoband	18q22.1	TNFRSF11A DSEL	2.13e-04	18	55	2	18q22.1
Cytoband	3q13.2	BTLA TMPRSS7	6.41e-04	31	55	2	3q13.2
Cytoband	1q32	CFH CFHR3	1.60e-03	49	55	2	1q32
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFH CFHR5 CSMD3 F13B CFHR3	2.57e-07	57	44	5	1179
GeneFamily	Wnt family\|Endogenous ligands	WNT7B WNT9B WNT4	1.27e-05	19	44	3	360
GeneFamily	Complement system\|Sushi domain containing	CFH CFHR5 CFHR3	9.08e-05	36	44	3	492
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	NEIL3 RBCK1	1.18e-03	21	44	2	89
GeneFamily	CD molecules\|Tumor necrosis factor receptor superfamily\|Death inducing signaling complex	TNFRSF11A TNFRSF4	2.25e-03	29	44	2	782
GeneFamily	Endogenous ligands	PROK2 VWF WNT7B WNT4	2.59e-03	237	44	4	542
GeneFamily	Ring finger proteins	PJA2 PJA1 RFWD3 RBCK1	4.41e-03	275	44	4	58
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	IGSF22 TRIO UNC5C	7.03e-03	161	44	3	593
GeneFamily	Immunoglobulin like domain containing	BTLA IGSF1 LY9	1.15e-02	193	44	3	594
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	BTLA TNFRSF11A LY9 TNFRSF4	1.52e-02	394	44	4	471
Coexpression	NABA_MATRISOME	CCN6 VWF LPA WNT7B PDGFD WNT9B ADAMTS17 LAMA2 MUC5B WNT4 VWDE F13B	9.34e-07	1008	55	12	MM17056
Coexpression	NABA_MATRISOME	CCN6 VWF LPA WNT7B PDGFD WNT9B ADAMTS17 LAMA2 MUC5B WNT4 VWDE F13B	1.12e-06	1026	55	12	M5889
Coexpression	VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN	PROK2 CFH WNT7B STAB1 CFHR3	9.52e-06	135	55	5	M5825
Coexpression	VALK_AML_CLUSTER_3	CFH PDGFD TNFRSF4	5.00e-05	34	55	3	M9858
Coexpression	GSE25123_CTRL_VS_ROSIGLITAZONE_STIM_PPARG_KO_MACROPHAGE_DN	CFH OVOL1 MUC5B LY9 PLEKHB1	6.13e-05	199	55	5	M7998
Coexpression	GSE43955_1H_VS_60H_ACT_CD4_TCELL_WITH_TGFB_IL6_UP	CFH VWF LAMA2 PJA1 TNFRSF4	6.28e-05	200	55	5	M9682
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	PROK2 OVOL1 WNT9B TNFRSF11A WNT4 GRM7	8.38e-05	345	55	6	M2009
Coexpression	MIKKELSEN_NPC_HCP_WITH_H3K27ME3	PROK2 OVOL1 WNT9B TNFRSF11A WNT4 GRM7	8.65e-05	347	55	6	MM860
ToppCell	Parenchymal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PROK2 OVOL1 UNC5C NEIL3 CSMD3 CFHR3	1.40e-07	193	55	6	df4afb4848eb9d7d8d39e5c612919663cbbb2514
ToppCell	Parenchymal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PROK2 OVOL1 UNC5C NEIL3 CSMD3 CFHR3	1.40e-07	193	55	6	ab36d684bde8fe77d11a5188425135328052c58b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH EEF1AKMT4-ECE2 UNC5C NEIL3 GRM7	1.42e-06	156	55	5	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH EEF1AKMT4-ECE2 UNC5C NEIL3 GRM7	1.42e-06	156	55	5	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	Adult-Immune-dendritic_cell-D175\|Adult / Lineage, Cell type, age group and donor	CDCA7 ZNF366 BTLA TNFRSF11A ZXDA	2.57e-06	176	55	5	1f0f1f953e6d61119f342de0d980aa1287511dba
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CFH VWF PLEKHB1 TNFRSF4 STAB1	2.87e-06	180	55	5	5861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCell	lymphoid-NK_cell-TNFRSF18+IL7R+_NK_cell\|World / Lineage, cell class and subclass	CCNJL CFH PDGFD UNC5C TNFRSF4	2.95e-06	181	55	5	0d096d7d557fd2e71b35e41816e11d7e83cd9210
ToppCell	lymphoid-NK_cell-TNFRSF18+IL7R+_NK_cell\|lymphoid / Lineage, cell class and subclass	CCNJL CFH PDGFD UNC5C TNFRSF4	3.46e-06	187	55	5	99dfa50f6325b0d66d23ee8dcaa6437e7161628a
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	WNT4 DSEL GRM7 VWDE ECE2	3.55e-06	188	55	5	c66fccdfe68760b8c3efca77e3c25966dc9a8a5f
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	CFH PDGFD UNC5C ADAMTS17 LAMA2	3.83e-06	191	55	5	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	RV-01._Fibroblast_I\|RV / Chamber and Cluster_Paper	CFH PDGFD UNC5C ADAMTS17 LAMA2	3.93e-06	192	55	5	356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	CFH VWF PDGFD UNC5C LAMA2	3.93e-06	192	55	5	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH PDGFD UNC5C PJA1 CSMD3	4.45e-06	197	55	5	236a40eb6c08e1d179cf0fb5450b032975c5f6b6
ToppCell	distal-1-mesenchymal-Myofibroblast\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH UNC5C LAMA2 IGSF1 GRM7	4.68e-06	199	55	5	58c36f5a30c6862b7f5587a0b9bc31da99e43dd5
ToppCell	distal-mesenchymal-Myofibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH UNC5C LAMA2 IGSF1 GRM7	4.68e-06	199	55	5	79917b5225cb45b4a0ea937f79f1752346e4346e
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Vipr2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CDCA7 PDGFD ADAMTS17 TAFA2	2.71e-05	140	55	4	72c272f44e5600b3037c1dbf9d3a4669a35588d8
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Whrn_Tox2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	WNT7B WNT4 TMPRSS7 TAFA2	2.94e-05	143	55	4	36ce6f163fb33141c86288086c354b91853fad25
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF366 NEIL3 RFWD3 TNFRSF4	4.03e-05	155	55	4	969fc4c98a96bf2f436e8e63d4deb2183ef3b864
ToppCell	PND03-Immune-Immune_Myeloid-DC-maDC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	UBE2L6 ZNF366 TNFRSF11A TNFRSF4	4.13e-05	156	55	4	095281ea78aefa0ee638191a03f8d6f62a86a9ff
ToppCell	PND03-Immune-Immune_Myeloid-DC-maDC-maDC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	UBE2L6 ZNF366 TNFRSF11A TNFRSF4	4.13e-05	156	55	4	29b04143f71a0ecc600ac670abd1d521bee55fe7
ToppCell	droplet-Thymus-nan-18m-Myeloid-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBE2L6 MUC5B WNT4 SLC26A6	4.24e-05	157	55	4	a9e077f686382303f0437ebfa4f11d273ba9fe40
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	VWF ZNF366 PDGFD TMPRSS7	5.14e-05	165	55	4	a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8\|TCGA-Liver / Sample_Type by Project: Shred V9	CFH VWF F13B CFHR3	5.91e-05	171	55	4	c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFH TRIO UNC5C LAMA2	6.04e-05	172	55	4	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	primary_auditory_cortex_(A1C)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PROK2 PDGFD ECE2 ZNF541	6.04e-05	172	55	4	20ea9db009370aa6235365ce93e153eb5b28db94
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CFH ADAMTS17 IGSF1 TMPRSS7	6.32e-05	174	55	4	3c47d069bd836599a8d40eae485c23d4d3487517
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFH NEIL3 BTLA DSEL	6.32e-05	174	55	4	09b091e24317c3f7bac043f04762a533e30793de
ToppCell	10x5'-blood-Lymphocytic_Invariant-Inducer-like\|blood / Manually curated celltypes from each tissue	CFH OVOL1 WNT4 DNAH7	6.32e-05	174	55	4	51be6f29308c01593978cbee92114151a5916c9c
ToppCell	TCGA-Liver\|World / Sample_Type by Project: Shred V9	LPA CFHR5 F13B CFHR3	6.32e-05	174	55	4	452932f08cf53e5949672a025d78cecb874aa4b0
ToppCell	TCGA-Colorectal-Recurrent_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	LPA CFHR5 F13B CFHR3	6.46e-05	175	55	4	7f74961436f88c0e380819095e6104489914d765
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH UNC5C LAMA2 ADGRG4	6.46e-05	175	55	4	795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCell	TCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	LPA CFHR5 F13B CFHR3	6.46e-05	175	55	4	bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell	10x5'-blood-Lymphocytic_Invariant-Inducer-like-MAIT\|blood / Manually curated celltypes from each tissue	CFH OVOL1 WNT4 DNAH7	6.46e-05	175	55	4	b4e4b66e89f79999768a6192c8404cb2465f920b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ADAMTS17 LAMA2 GRM7	6.75e-05	177	55	4	9ec7f1e64312d26d434b3312b58386715dbad644
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH ADAMTS17 LAMA2 GRM7	6.75e-05	177	55	4	016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA2 GRM7 DNAH7 TAFA2	6.90e-05	178	55	4	0e1bedf991189d0ef9b40dac9281bdf4739333a1
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CFH VWF PDGFD ZNF541	7.05e-05	179	55	4	8c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCell	Epithelial-basal_cell\|World / Lineage, Cell type, age group and donor	CFH LPA WNT4 VWDE	7.05e-05	179	55	4	d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	CFH UNC5C LAMA2 CFHR3	7.36e-05	181	55	4	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	5'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF ZNF366 BTLA TNFRSF4	7.36e-05	181	55	4	7d7d1edeae4e0ebe40b324d1231cd26e27ba9d42
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF ZNF366 TNFRSF4 STAB1	7.52e-05	182	55	4	63b41b538b26bc899558807fd035e543611f8c52
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILCP\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TNFRSF11A LY9 GRM7 TNFRSF4	7.52e-05	182	55	4	6bd48c5d60a259719f65cacee4b8135247e78fa9
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	VWF PDGFD UNC5C LAMA2	7.52e-05	182	55	4	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH UNC5C LAMA2 ADGRG4	7.85e-05	184	55	4	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA2 GRM7 DNAH7 TAFA2	7.85e-05	184	55	4	6475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCell	facs-Heart-LA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH VWF ADAMTS17 STAB1	8.01e-05	185	55	4	1ecfca049c0c1110fd1b2256db7cb7abda6afb04
ToppCell	facs-Heart-LA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH VWF ADAMTS17 STAB1	8.01e-05	185	55	4	b6df1412b579d40ed5df806f9c54bd1fbb9a1e15
ToppCell	droplet-Bladder-BLADDER-1m-Hematologic-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF CDCA7 NEIL3 LY9	8.01e-05	185	55	4	969248b63d4ce335f223528de756bcddffadbd77
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OVOL1 WNT7B MUC5B WNT4	8.18e-05	186	55	4	37b93ebd64ebbd08193a746e5bc9b350c2570733
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH ADAMTS17 LAMA2 GRM7	8.18e-05	186	55	4	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OVOL1 WNT7B MUC5B WNT4	8.52e-05	188	55	4	8ffb5394f7b00ea483a5fe4df894d22fda935e5c
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CFH PDGFD UNC5C LAMA2	8.52e-05	188	55	4	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	Control-Fibroblasts-Adventitial_FB\|Control / group, cell type (main and fine annotations)	CFH PDGFD UNC5C LAMA2	8.52e-05	188	55	4	706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH PDGFD WNT4 CFHR3	8.52e-05	188	55	4	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OVOL1 WNT7B MUC5B WNT4	8.52e-05	188	55	4	137ed9958044fab7a13648affb469585d1c48cf6
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNJL CFH VWF STAB1	8.70e-05	189	55	4	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CFH VWF ZNF366 PDGFD	8.70e-05	189	55	4	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNJL CFH VWF STAB1	8.70e-05	189	55	4	fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	CFH VWF ZNF366 PDGFD	8.88e-05	190	55	4	1519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCell	facs-Trachea-18m-Epithelial-airway_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OVOL1 WNT7B MUC5B WNT4	9.06e-05	191	55	4	cd4e2e883c4955fb2d875e41bb6ebc680994dc8c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFH PDGFD LAMA2 ADGRG4	9.06e-05	191	55	4	2c51850f5c559d665b8a27a12b75af9ed58dffe1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFH UNC5C ADAMTS17 LAMA2	9.06e-05	191	55	4	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH VWF ADAMTS17 STAB1	9.25e-05	192	55	4	0b9b2eaed45456d7d74ce78a64ef4a26ac2458fb
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LPA TNFRSF11A PLEKHB1 ADGRG4	9.25e-05	192	55	4	d6ea34391c3f730684b82e912d9cf55e928b3311
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3\|lymph-node_spleen / Manually curated celltypes from each tissue	UNC5C TNFRSF11A GRM7 TNFRSF4	9.25e-05	192	55	4	e16035b3328f9b1b2e28d234c62ba88387540550
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFH UNC5C ADAMTS17 LAMA2	9.25e-05	192	55	4	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	facs-Trachea-18m-Epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OVOL1 WNT7B MUC5B WNT4	9.25e-05	192	55	4	c5823c5d4c58a4e9121a4b7d7256481d6d9e9b7f
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell\|Adult / Lineage, Cell type, age group and donor	CFH UNC5C LAMA2 ADGRG4	9.25e-05	192	55	4	d21f0f577156f17c899b08871046a26b88aea011
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CFH PDGFD LAMA2 CSMD3	9.43e-05	193	55	4	549a0b750c860b615aff767ad04c9a9d20f802f0
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH UNC5C LAMA2 IGSF1	9.43e-05	193	55	4	7c0d84b92470bfda2db1e5007feee7c1235a0a78
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BTLA LY9 VWDE TNFRSF4	9.43e-05	193	55	4	7deb439943d35a4e825674b2b7dcddb45d366ad1
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	CFH PDGFD UNC5C LAMA2	9.43e-05	193	55	4	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	CFH PDGFD UNC5C LAMA2	9.62e-05	194	55	4	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNJL CFH VWF STAB1	9.62e-05	194	55	4	c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	CFH PDGFD UNC5C LAMA2	9.62e-05	194	55	4	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	CFH PDGFD UNC5C LAMA2	9.62e-05	194	55	4	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PJA2 TRIO LAMA2 DSEL	9.62e-05	194	55	4	8b81f039f5b25d35a4d5a41b27d4d9360ba22f15
ToppCell	LA-02._Fibroblast_II\|LA / Chamber and Cluster_Paper	CFH PDGFD UNC5C LAMA2	9.62e-05	194	55	4	234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCell	PCW_05-06-Endothelial-Endothelial_mature\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CFH VWF TNFRSF4 STAB1	9.82e-05	195	55	4	54fde2cfa51ab3a2d48d2426494ca6f0ce77f725
ToppCell	COVID-19-Heart-Fib_1\|Heart / Disease (COVID-19 only), tissue and cell type	CFH PDGFD UNC5C LAMA2	9.82e-05	195	55	4	f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNJL CFH VWF STAB1	9.82e-05	195	55	4	df644b4c3ddccd34614ece5a2378000e6bc0fa10
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF ZNF366 TNFRSF4 STAB1	9.82e-05	195	55	4	ccfb80e3bfdf5304fa798e0a47b473955ecc0c6d
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	CFH PDGFD UNC5C LAMA2	9.82e-05	195	55	4	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	RA-02._Fibroblast_II\|RA / Chamber and Cluster_Paper	CFH PDGFD UNC5C LAMA2	9.82e-05	195	55	4	6a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell	Tracheal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NEIL3 BTLA LY9 TNFRSF4	9.82e-05	195	55	4	df009b18898c10686f75cf72b4ec0eff18f5bb50
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH VWF WNT4 STAB1	1.00e-04	196	55	4	7d5eaed189aa6116f3799be010139fb675ec65e0
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFH PJA1 DSEL CSMD3	1.00e-04	196	55	4	a7adc0e0baef261d0937e4e8351321d41beca82f
ToppCell	Healthy-CD4+_CTL\|Healthy / disease group, cell group and cell class	PROK2 CFH LY9 DSEL	1.00e-04	196	55	4	9da0ea4ad84d6e20e4349d3d1a8cc4d61d08c84f
ToppCell	droplet-Heart-nan-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH VWF ADAMTS17 STAB1	1.00e-04	196	55	4	e386526332138e636aef2542c11316347a45689c
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-ILC\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CDCA7 ADAMTS17 CSMD3 TNFRSF4	1.00e-04	196	55	4	1cc2b11764584129703ec61965e8ec4e051464e7
ToppCell	3'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF PDGFD TNFRSF4 STAB1	1.00e-04	196	55	4	aa52f77f80c3fe23369347a34e0b3188b768a763
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFH VWF WNT4 STAB1	1.00e-04	196	55	4	dbf154b3d166ffd07be717dac8d8a3350ac63e16
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CFH UNC5C ADAMTS17 LAMA2	1.00e-04	196	55	4	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_basal-Dividing_Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	OVOL1 CDCA7 NEIL3 WNT4	1.02e-04	197	55	4	25bbe270d0897b9b1bd00d205f66efd1def81b99
ToppCell	distal-mesenchymal-Myofibroblast-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CFH LAMA2 GRM7 CFHR3	1.04e-04	198	55	4	beef5075ba6dcd4d0a447bc4e57efcaf2e93c546
ToppCell	LPS_only-Epithelial_airway-airway_epithelial\|LPS_only / Treatment groups by lineage, cell group, cell type	OVOL1 WNT7B MUC5B DNAH7	1.04e-04	198	55	4	e035380578c01b0243bfef29ca9b50cc17cce771
ToppCell	LPS_only-Epithelial_airway\|LPS_only / Treatment groups by lineage, cell group, cell type	OVOL1 WNT7B MUC5B DNAH7	1.04e-04	198	55	4	ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Chat.Synpr-Slc5a7_(Neuron.Gad1Gad2-Chat.Synpr-Slc5a7)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PROK2 CCN6 F13B	1.05e-04	74	55	3	0d705c42e7741b861ba5a9f1af83b2c5c6f23fb6
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2-Chat.Synpr-Slc5a7_(Neuron.Gad1Gad2-Chat.Synpr-Slc5a7)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PROK2 CCN6 F13B	1.05e-04	74	55	3	c49bda52aa4ead9483c2f27d63458034e75699bd
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Airway-Club\|Control_saline / Treatment groups by lineage, cell group, cell type	OVOL1 WNT7B MUC5B IGSF1	1.06e-04	199	55	4	5cc8b553a58669a30eb10845beb23983dcdf5a6a
Drug	Factor Xiiib	CFH LPA CFHR5 F13B	1.30e-06	35	53	4	CID000126166
Drug	(2S)-N-[4-(aminomethyl)-1,1-dioxothian-4-yl]-2-[1-(benzenesulfonamido)ethylideneamino]-3-(1-methylcyclopentyl)propanamide	CFH CFHR3	5.32e-06	2	53	2	CID011840931
Disease	coagulation factor measurement	CFH VWF CFHR5	6.46e-06	20	54	3	EFO_0004634
Disease	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase measurement	CFH CFHR3	9.85e-06	3	54	2	EFO_0801568
Disease	complement C5 measurement	CFHR5 F13B	9.85e-06	3	54	2	EFO_0020278
Disease	anaphase-promoting complex subunit 7 measurement	CFH CFHR3	9.85e-06	3	54	2	EFO_0801381
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFH CFHR3	9.85e-06	3	54	2	C2749604
Disease	HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1	CFH CFHR3	9.85e-06	3	54	2	235400
Disease	Hemolytic uremic syndrome, atypical, susceptibility to, 1	CFH CFHR3	9.85e-06	3	54	2	cv:C2749604
Disease	platelet-derived growth factor receptor alpha measurement	CFHR5 F13B	9.85e-06	3	54	2	EFO_0021844
Disease	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial measurement	CFH CFHR3	1.97e-05	4	54	2	EFO_0803292
Disease	Meningococcal Infections	CFH CFHR3	1.97e-05	4	54	2	C0025303
Disease	Complement deficiency disease	CFH CFHR5 CFHR3	3.04e-05	33	54	3	C0272242
Disease	Drug habituation	ZNF366 TMPRSS7 CSMD3 GRM7	5.96e-05	115	54	4	C0013170
Disease	Drug abuse	ZNF366 TMPRSS7 CSMD3 GRM7	5.96e-05	115	54	4	C0013146
Disease	Prescription Drug Abuse	ZNF366 TMPRSS7 CSMD3 GRM7	5.96e-05	115	54	4	C4316881
Disease	Substance-Related Disorders	ZNF366 TMPRSS7 CSMD3 GRM7	5.96e-05	115	54	4	C0236969
Disease	Drug Use Disorders	ZNF366 TMPRSS7 CSMD3 GRM7	5.96e-05	115	54	4	C0013222
Disease	Drug Dependence	ZNF366 TMPRSS7 CSMD3 GRM7	5.96e-05	115	54	4	C1510472
Disease	Substance Dependence	ZNF366 TMPRSS7 CSMD3 GRM7	5.96e-05	115	54	4	C0038580
Disease	Substance Use Disorders	ZNF366 TMPRSS7 CSMD3 GRM7	5.96e-05	115	54	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	ZNF366 TMPRSS7 CSMD3 GRM7	5.96e-05	115	54	4	C0029231
Disease	Substance abuse problem	ZNF366 TMPRSS7 CSMD3 GRM7	6.16e-05	116	54	4	C0740858
Disease	complement factor H-related protein 5 measurement	CFH CFHR5 F13B	6.32e-05	42	54	3	EFO_0008098
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	VWF PDGFD	9.14e-05	8	54	2	DOID:4783 (biomarker_via_orthology)
Disease	atypical hemolytic-uremic syndrome (is_implicated_in)	CFH CFHR3	9.14e-05	8	54	2	DOID:0080301 (is_implicated_in)
Disease	C3 glomerulopathy	CFH CFHR5	1.17e-04	9	54	2	C4087273
Disease	Atypical hemolytic-uremic syndrome	CFH CFHR3	1.17e-04	9	54	2	cv:C2931788
Disease	Hemolytic-uremic syndrome	CFH CFHR3	1.17e-04	9	54	2	cv:C0019061
Disease	Atypical Hemolytic Uremic Syndrome	CFH CFHR3	1.47e-04	10	54	2	C2931788
Disease	complement factor H-related protein 1 measurement	CFH CFHR5 F13B	1.50e-04	56	54	3	EFO_0600054
Disease	hemopexin measurement	CFH CFHR5	1.79e-04	11	54	2	EFO_0008149
Disease	methylcobalamin deficiency type cblE, brain serotonin transporter measurement	VWF TRIO	3.88e-04	16	54	2	EFO_0004569, MONDO_0009354
Disease	SLAM family member 7 measurement	CFH LY9	4.39e-04	17	54	2	EFO_0008287
Disease	Age-related macular degeneration	CFH CFHR3	4.94e-04	18	54	2	cv:C0242383
Disease	brain age measurement	EEF1AKMT4-ECE2 ECE2	6.12e-04	20	54	2	EFO_0010602
Disease	Deep Vein Thrombosis	LPA F13B	6.75e-04	21	54	2	C0149871
Disease	Venous Thrombosis	LPA F13B	6.75e-04	21	54	2	C0042487
Disease	L lactate dehydrogenase measurement	CFH STAB1	1.04e-03	26	54	2	EFO_0004808
Disease	pancreatic ductal adenocarcinoma (is_marker_for)	SMAD2 CFHR3	1.12e-03	27	54	2	DOID:3498 (is_marker_for)
Disease	factor VIII measurement, von Willebrand factor measurement	VWF ZNF366	1.12e-03	27	54	2	EFO_0004629, EFO_0004630
Disease	complement factor H-related protein 2 measurement	CFH F13B	1.29e-03	29	54	2	EFO_0600055
Disease	Age related macular degeneration	CFH CFHR3	1.38e-03	30	54	2	C0242383
Disease	unipolar depression	CFH TRIO WNT7B UNC5C MUC5B CSMD3 GRM7 DNAH7	1.49e-03	1206	54	8	EFO_0003761
Disease	angina pectoris	CFH LPA UNC5C	1.57e-03	125	54	3	EFO_0003913
Disease	frontotemporal dementia	PJA2 VWDE	1.57e-03	32	54	2	MONDO_0017276

Protein segments in the cluster

Peptide	Gene	Start	Entry
VCLWKGCKVYNTPST	AEBP2	296	Q6ZN18
WSDHRPVCKVKTCGS	CSMD3	536	Q7Z407
RPHVTWCKLNGTTCV	BTLA	66	Q7Z6A9
CSISINTGKSQWEKP	ADGRG4	2426	Q8IZF6
TWPTTCPRKTKECLK	CCNJL	216	Q8IV13
WSPTPRCIRVKTCSK	CFH	436	P08603
SQCSASCGKGVWKRT	ADAMTS17	931	Q8TE56
SCGKGVWKRTVACTN	ADAMTS17	936	Q8TE56
VWKRTVACTNSQGKC	ADAMTS17	941	Q8TE56
TTSQGTTRCQPKCEW	MUC5B	1776	Q9HC84
ISTWLKGQVRKCPQC	RFWD3	316	Q6PCD5
SVSAKIPETKWCQKC	MAP4K3	661	Q8IVH8
WTCVVCTLINKPSSK	NEIL3	321	Q8TAT5
TVCHTEICWVTKGPR	RBCK1	466	Q9BYM8
KKSCVPRWQTCISNT	ECE2	466	P0DPD6
GWSLTPKCTKLKCSS	F13B	201	P05160
VNWRSCTCNSGKTVK	PDGFD	311	Q9GZP0
STVAVTSVCWSPKGK	NUP214	191	P35658
TIGEKCSKCAPNTWG	LAMA2	1036	P24043
LVKKPCVSTCKRNWS	OVOL1	6	O14753
CAVSIWVKSIRICTP	PROK2	46	Q9HC23
VQATKWTPCSRTCGM	CCN6	211	O95389
GTKKSCVPRWQTCIS	EEF1AKMT4-ECE2	536	P0DPD8
PKAQTTVTCTEKGWS	CFHR3	121	Q02985
WSKCTKIPISGTCYT	IGSF22	846	Q8N9C0
KNLTLWCRSPSGSTK	IGSF1	606	Q8N6C5
KEWTTLCKGRDIPCS	DNAH7	2931	Q8WXX0
KKATTVTGTPCQEWA	LPA	1731	P08519
WTTLPTCVEQVKTCG	CFHR5	256	Q9BXR6
WKRKGRCSVPAFCSS	LY9	476	Q9HBG7
QRKKTQKGTPCCWTC	GRM7	531	Q14831
STCSQPICAKWTRTE	DSEL	821	Q8IZU8
ECKVLPDRKGWSCSS	TAFA2	106	Q8N3H0
CWKLPQSKVGTVVTA	SLC26A6	256	Q9BXS9
KTIDTKTNCRNPDCW	CDCA7	276	Q9BWT1
GWSGKRCNTPICLQK	VWDE	1511	Q8N2E2
SGSCTTKTCWTTLPK	WNT7B	206	P56706
KVVTWRTATLCPQSC	VWF	1116	P04275
PPKCKCTWKFQTSLS	TMPRSS7	391	Q7RTY8
SKVRCVTRSWSPCKV	PLEKHB1	146	Q9UF11
NTKCVTIPSTCSEIW	SMAD2	71	Q15796
SSENWKPCTKTCQVL	UBE2L6	91	O14933
SPWSSCNKNVVGRCK	TTMP	51	Q5BVD1
SCAAIKKQTCPSGWL	STAB1	46	Q9NY15
CKPWTNCTLAGKHTL	TNFRSF4	141	P43489
WKSRCPISSCNKLFT	ZXDA	541	P98168
SSSPWQCPVCRSIKK	ZMYND11	136	Q15326
VGGSQKRWQCPTCEK	ZNF366	246	Q8N895
VSGSCEVKTCWRAVP	WNT4	211	P56705
WKVICKSCISQTPGI	XAGE1A	36	Q9HD64
SGSCAVRTCWKQLSP	WNT9B	216	O14905
CVSIWLQKSGTCPVC	PJA1	621	Q8NG27
KIACTTLCPVDGRWT	UNC5C	306	O95185
VSIWLQKSGTCPVCR	PJA2	661	O43164
VISCWKGVCVPQTTT	TMEM78	11	Q5T7P6
CRVCGRPKASITWKG	TRIO	2706	O75962
TDKCRPWTNCTFLGK	TNFRSF11A	166	Q9Y6Q6
WTKPRSTFVCKNCSQ	ZNF541	831	Q9H0D2