Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	IPPK AATK EGFR GUK1 ULK1 PFKFB2 PALS2 EIF2AK3 TENT2 EPHA3	1.31e-04	938	52	10	GO:0016772
GeneOntologyMolecularFunction	kinase activity	IPPK AATK EGFR GUK1 ULK1 PFKFB2 PALS2 EIF2AK3 EPHA3	1.41e-04	764	52	9	GO:0016301
GeneOntologyMolecularFunction	protein phosphatase binding	DAB2IP EGFR LILRB2 GRIN3A EIF2AK3	2.13e-04	210	52	5	GO:0019903
GeneOntologyMolecularFunction	guanylate kinase activity	GUK1 PALS2	3.60e-04	11	52	2	GO:0004385
GeneOntologyMolecularFunction	phosphatase binding	DAB2IP EGFR LILRB2 GRIN3A EIF2AK3	6.09e-04	264	52	5	GO:0019902
Domain	DH_1	NET1 DNMBP SPATA13	6.79e-04	63	51	3	PS00741
Domain	RhoGEF	NET1 DNMBP SPATA13	8.48e-04	68	51	3	SM00325
Domain	Guanylate_kinase_CS	GUK1 PALS2	8.56e-04	16	51	2	IPR020590
Domain	RhoGEF	NET1 DNMBP SPATA13	9.23e-04	70	51	3	PF00621
Domain	DH_2	NET1 DNMBP SPATA13	9.23e-04	70	51	3	PS50010
Domain	DH-domain	NET1 DNMBP SPATA13	9.62e-04	71	51	3	IPR000219
Domain	-	NET1 DNMBP SPATA13	9.62e-04	71	51	3	1.20.900.10
Domain	SH3_2	SORBS3 PALS2 DNMBP	1.67e-03	86	51	3	IPR011511
Domain	SH3_2	SORBS3 PALS2 DNMBP	1.67e-03	86	51	3	PF07653
Domain	GUANYLATE_KINASE_2	GUK1 PALS2	1.78e-03	23	51	2	PS50052
Domain	GUANYLATE_KINASE_1	GUK1 PALS2	1.78e-03	23	51	2	PS00856
Domain	Guanylate_kin	GUK1 PALS2	2.28e-03	26	51	2	PF00625
Domain	GK/Ca_channel_bsu	GUK1 PALS2	2.28e-03	26	51	2	IPR008145
Domain	Guanylate_kin-like_dom	GUK1 PALS2	2.28e-03	26	51	2	IPR008144
Domain	GuKc	GUK1 PALS2	2.28e-03	26	51	2	SM00072
Domain	PROTEIN_KINASE_TYR	AATK EGFR EPHA3	2.36e-03	97	51	3	PS00109
Domain	Tyr_kinase_AS	AATK EGFR EPHA3	2.36e-03	97	51	3	IPR008266
Domain	SH3	SORBS3 PALS2 DNMBP SPATA13	2.84e-03	216	51	4	SM00326
Domain	SH3	SORBS3 PALS2 DNMBP SPATA13	2.84e-03	216	51	4	PS50002
Domain	SH3_domain	SORBS3 PALS2 DNMBP SPATA13	3.04e-03	220	51	4	IPR001452
Domain	Protein_kinase_ATP_BS	AATK EGFR ULK1 EIF2AK3 EPHA3	3.66e-03	379	51	5	IPR017441
Domain	GDS_CDC24_CS	NET1 DNMBP	5.08e-03	39	51	2	IPR001331
Domain	Peripla_BP_I	GRIN3A GRM4	5.08e-03	39	51	2	IPR028082
Domain	Pkinase_Tyr	AATK EGFR EPHA3	5.26e-03	129	51	3	PF07714
Domain	SAM_2	CNKSR1 EPHA3	6.15e-03	43	51	2	PF07647
Domain	Ser-Thr/Tyr_kinase_cat_dom	AATK EGFR EPHA3	6.34e-03	138	51	3	IPR001245
Domain	PH	DAB2IP CNKSR1 NET1 SPATA13	6.93e-03	278	51	4	SM00233
Domain	PH_DOMAIN	DAB2IP CNKSR1 NET1 SPATA13	7.02e-03	279	51	4	PS50003
Domain	PH_domain	DAB2IP CNKSR1 NET1 SPATA13	7.11e-03	280	51	4	IPR001849
Domain	-	CNKSR1 SYNPO2L PALS2	7.98e-03	150	51	3	2.30.42.10
Domain	PDZ	CNKSR1 SYNPO2L PALS2	8.12e-03	151	51	3	PS50106
Domain	PROTEIN_KINASE_ATP	AATK EGFR ULK1 EIF2AK3 EPHA3	8.14e-03	459	51	5	PS00107
Pubmed	Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle.	SYNE2 EMD	6.57e-06	3	52	2	15671068
Pubmed	Epidermal growth factor receptor and podocin predict nephropathy progression in type 2 diabetic patients through interaction with the autophagy influencer ULK-1.	EGFR ULK1	6.57e-06	3	52	2	30545560
Pubmed	Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface.	EGFR SORBS3	6.57e-06	3	52	2	16923119
Pubmed	EGFR and SYNE2 are associated with p21 expression and SYNE2 variants predict post-operative clinical outcomes in HBV-related hepatocellular carcinoma.	EGFR SYNE2	6.57e-06	3	52	2	27502069
Pubmed	Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.	SYNE2 EMD	6.57e-06	3	52	2	17462627
Pubmed	PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1.	CLSPN EIF2AK3	6.57e-06	3	52	2	27375025
Pubmed	ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation.	EGFR LILRB2	6.57e-06	3	52	2	33537094
Pubmed	The clinical value of the combined detection of sEGFR, CA125 and HE4 for epithelial ovarian cancer diagnosis.	EGFR MUC16	6.57e-06	3	52	2	32016961
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DAB2IP KIF21B FAM171A1 SYNJ1 TAX1BP1 SYNE2 GRM4 CAMSAP2 SPATA13	1.16e-05	963	52	9	28671696
Pubmed	The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus.	EGFR EMD	1.31e-05	4	52	2	20937808
Pubmed	TMEM43/LUMA is a key signaling component mediating EGFR-induced NF-κB activation and tumor progression.	EGFR BCL10	1.31e-05	4	52	2	27991920
Pubmed	Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes.	SYNE2 EMD	2.19e-05	5	52	2	19933576
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	DAB2IP ASXL1 AATK SYNJ1 SYNE2	2.20e-05	225	52	5	12168954
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DAB2IP ASXL1 RIPOR1 ULK1 CAMSAP2 SPATA13	3.20e-05	407	52	6	12693553
Pubmed	Samp1 is a component of TAN lines and is required for nuclear movement.	SYNE2 EMD	3.28e-05	6	52	2	22349700
Pubmed	Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.	SYNE2 EMD	3.28e-05	6	52	2	38569934
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DAB2IP AATK SYNJ1 RTTN SORBS3 RIPOR1 ULK1 DNMBP SPATA13	3.44e-05	1105	52	9	35748872
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	TCTN3 PLXDC2 NET1 SYNPO2L FAM241B DNMBP	3.56e-05	415	52	6	16385451
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	AATK EGFR MUC16 EMD GRM4 EPHA3	3.81e-05	420	52	6	28065597
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	DAB2IP FAM171A1 EGFR ROBO2 PALS2 EPHA3	3.86e-05	421	52	6	36976175
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FAM171A1 SYNJ1 NET1 SYNE2 PFKFB2 DNMBP CAMSAP2 SPATA13	3.92e-05	861	52	8	36931259
Pubmed	Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.	TAX1BP1 ULK1	4.58e-05	7	52	2	28877469
Pubmed	Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.	TCTN3 DNMBP	6.10e-05	8	52	2	22905720
Pubmed	Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas.	EGFR EPHA3	7.84e-05	9	52	2	20838624
Pubmed	The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.	NET1 PALS2	7.84e-05	9	52	2	17938206
Pubmed	Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.	PALS2 DNMBP SPATA13	8.26e-05	56	52	3	22745667
Pubmed	Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.	SYNE2 EMD	9.79e-05	10	52	2	28533284
Pubmed	Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9.	ULK1 PFKFB2	1.20e-04	11	52	2	25266655
Pubmed	Meta-analysis identifies six new susceptibility loci for atrial fibrillation.	SYNE2 SYNPO2L	1.43e-04	12	52	2	22544366
Pubmed	Developmental activities of the complement pathway in migrating neurons.	OPRPN EMD	1.43e-04	12	52	2	28462915
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	DAB2IP FAM171A1 EGFR SYNE2 SORBS3 NUP133 KIAA1549 EMD	1.55e-04	1049	52	8	27880917
Pubmed	The DNA sequence and comparative analysis of human chromosome 10.	FAM171A1 TCTN3 PLXDC2 SYNPO2L FAM241B	1.65e-04	345	52	5	15164054
Pubmed	Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.	TAX1BP1 ULK1	1.69e-04	13	52	2	36692217
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	EGFR SYNE2 EMD EIF2AK3	1.94e-04	191	52	4	31177093
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	EGFR ULK1 EPHA3	2.22e-04	78	52	3	17192257
Pubmed	STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.	ULK1 EIF2AK3	2.27e-04	15	52	2	29056340
Pubmed	A molecular mechanism underlying the neural-specific defect in torsinA mutant mice.	SYNE2 EMD	2.27e-04	15	52	2	20457914
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	DAB2IP DHX58 TAX1BP1 DNMBP EIF2AK3	2.32e-04	371	52	5	15747579
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	SYNJ1 NET1 RIPOR1 BCL10 PFKFB2	2.52e-04	378	52	5	34315543
Pubmed	The protein tyrosine kinase family of the human genome.	AATK EGFR EPHA3	2.66e-04	83	52	3	11114734
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AATK SYNJ1 SYNE2	3.06e-04	87	52	3	12465718
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	DNMBP SPATA13	3.30e-04	18	52	2	12799088
Pubmed	The transcription factor neurogenin 2 restricts cell migration from the cortex to the striatum.	ROBO2 EPHA3	4.09e-04	20	52	2	11748150
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ASXL1 SYNE2 DNMBP	4.88e-04	102	52	3	10231032
Pubmed	CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP.	CNKSR1 EGFR	4.97e-04	22	52	2	34187934
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	SYNE2 NUP133 DNMBP CAMSAP2	5.46e-04	251	52	4	29778605
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIN3A GRM4	5.93e-04	24	52	2	35746896
Pubmed	TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.	TAX1BP1 ULK1	5.93e-04	24	52	2	27693506
Pubmed	Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.	EGFR EPHA3	6.43e-04	25	52	2	15254900
Pubmed	Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.	EGFR NUP133	6.43e-04	25	52	2	24947832
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	NUP133 KIAA1549 EMD DNMBP	6.51e-04	263	52	4	34702444
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	SYNJ1 EGFR SYNE2 SORBS3 BCL10 EMD GPKOW	7.18e-04	1007	52	7	34597346
Pubmed	A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.	NUP133 EMD GPKOW	8.02e-04	121	52	3	22412018
Pubmed	Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.	BCL10 EIF2AK3	8.08e-04	28	52	2	24462114
Pubmed	Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha.	ASXL1 GRIN3A	8.67e-04	29	52	2	18239623
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	FAM171A1 SYNJ1 FHIP1A	8.81e-04	125	52	3	29467281
Pubmed	The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.	CNKSR1 SYNE2	9.29e-04	30	52	2	30480076
Pubmed	The unfolded protein response: integrating stress signals through the stress sensor IRE1α.	DAB2IP EIF2AK3	9.92e-04	31	52	2	22013210
Pubmed	Lem2 is essential for cardiac development by maintaining nuclear integrity.	SYNE2 EMD	1.06e-03	32	52	2	37067297
Pubmed	Global identification of modular cullin-RING ligase substrates.	NUP133 PFKFB2 EMD	1.08e-03	134	52	3	21963094
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	KIF21B NUP133 PFKFB2 EMD	1.24e-03	313	52	4	16196087
Interaction	RALBP1 interactions	AATK EGFR SYNE2 SORBS3 EMD DNMBP	1.17e-05	198	52	6	int:RALBP1
Interaction	ARHGAP15 interactions	DAB2IP SYNE2 SORBS3 DNMBP	1.61e-05	59	52	4	int:ARHGAP15
Interaction	GJA1 interactions	FAM171A1 EGFR SYNE2 KIAA1549 ROBO2 ULK1 EMD EIF2AK3 EPHA3	1.62e-05	583	52	9	int:GJA1
Cytoband	7p15	TAX1BP1 PALS2	1.14e-04	14	52	2	7p15
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	NET1 DNMBP SPATA13	1.43e-04	66	28	3	722
GeneFamily	PDZ domain containing	CNKSR1 SYNPO2L PALS2	1.64e-03	152	28	3	1220
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CNKSR1 NET1 SPATA13	3.87e-03	206	28	3	682
GeneFamily	Sterile alpha motif domain containing	CNKSR1 EPHA3	8.15e-03	88	28	2	760
GeneFamily	Fibronectin type III domain containing	ROBO2 EPHA3	2.53e-02	160	28	2	555
Coexpression	GSE20151_CTRL_VS_FUSOBACT_NUCLEATUM_NEUTROPHIL_DN	IPPK SYNJ1 BAZ2B GUK1 NUP133 EMD	2.70e-06	199	52	6	M4310
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	FAM171A1 ASXL1 EGFR BAZ2B SYNE2 NUP133 PALS2 DNMBP CAMSAP2	4.23e-05	856	52	9	M4500
Coexpression	GSE1460_DP_THYMOCYTE_VS_NAIVE_CD4_TCELL_ADULT_BLOOD_DN	FAM171A1 WWC3 NET1 EMD CAMSAP2	4.45e-05	197	52	5	M3465
Coexpression	GSE45881_CXCR6HI_VS_CXCR1LO_COLONIC_LAMINA_PROPRIA_UP	KIF21B SYNJ1 BAZ2B ULK1 TAF2	4.78e-05	200	52	5	M9889
Coexpression	GSE3982_NEUTROPHIL_VS_TH2_UP	SYNJ1 EGFR BAZ2B SYNE2 RIPOR1	4.78e-05	200	52	5	M5534
Coexpression	GSE8621_UNSTIM_VS_LPS_PRIMED_UNSTIM_MACROPHAGE_DN	SYNJ1 RTTN NUP133 DDI2 CAMSAP2	4.78e-05	200	52	5	M6980
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	KIF21B AATK SYNJ1 KIAA1549 ROBO2 GRIN3A GRM4 CAMSAP2 SPATA13 EPHA3	5.40e-05	1106	52	10	M39071
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000	PLXDC2 NET1 EGFR SYNE2 MUC16 ROBO2 EPHA3	1.01e-05	310	52	7	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k1_1000
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CNKSR1 EGFR MUC16 FAM241B FHIP1A	2.97e-06	192	52	5	8899d81306770adda893b5e146df1253971754c5
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CNKSR1 EGFR MUC16 FAM241B FHIP1A	2.97e-06	192	52	5	5fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-Klrb1a/b/c(-)_NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21B FAM241B GRIN3A EPHA3	4.12e-05	165	52	4	eeb58d4db64ad37dc6b441eab22b05c24862e1a9
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NET1 SYNE2 MUC16 PALS2	4.95e-05	173	52	4	30d67738633493d47f06ae452424382f069b6c0a
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NET1 SYNE2 MUC16 PALS2	5.06e-05	174	52	4	a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	EGFR ROBO2 CAMSAP2 EPHA3	5.65e-05	179	52	4	98c0c5c8034ae8a4b3ceea7fd1d0386ee5f89d09
ToppCell	droplet-Spleen-nan-24m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM171A1 NET1 EGFR KIAA1549	5.65e-05	179	52	4	d50d29f26d5a2cd8c4cd4e1244e1bb8de072d159
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	OXR1 SYNE2 KIAA1549 PALS2	6.16e-05	183	52	4	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	Mild/Remission-B_intermediate-10\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	LILRB2 PALS2 DNMBP SPATA13	6.16e-05	183	52	4	278064c9f0582463b83bf156d34e77f60187613b
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	OXR1 SYNE2 KIAA1549 PALS2	6.29e-05	184	52	4	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	COPD-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	EGFR MUC16 PALS2 FHIP1A	6.42e-05	185	52	4	23579988036fc1925992c31919750f9b3fe9f790
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PLXDC2 ACY3 RTTN SPATA13	6.69e-05	187	52	4	ba822dbceb47257129d6a8c9639c08d76de6d6a3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	OXR1 PLXDC2 KIAA1549 PALS2	6.69e-05	187	52	4	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EGFR ROBO2 GRIN3A PALS2	6.83e-05	188	52	4	433a25fe52914e07e7ba695881f9bcca2d9467ff
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ASXL1 WWC3 DNMBP SPATA13	6.83e-05	188	52	4	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	EGFR MUC16 PALS2 FHIP1A	6.98e-05	189	52	4	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	renal_cortex_nuclei-Adult_normal_reference\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	EGFR SYNE2 KIAA1549 PFKFB2	6.98e-05	189	52	4	a48df46274d51e84ffb40264646de7346104efb9
ToppCell	Non-neuronal-Postmitotic-Red_blood_cells-Low_Quality\|World / Primary Cells by Cluster	BAZ2B SYNE2 ROBO2 EPHA3	7.12e-05	190	52	4	31cf1367db5c04242621f7c98a10d094bc519e31
ToppCell	Non-neuronal-Postmitotic-Red_blood_cells\|World / Primary Cells by Cluster	BAZ2B SYNE2 ROBO2 EPHA3	7.12e-05	190	52	4	f0b82334375749d917e440c493f10340c52ea13c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	OXR1 PLXDC2 KIAA1549 PALS2	7.12e-05	190	52	4	989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell	Non-neuronal-Postmitotic-Red_blood_cells-Low_Quality-14\|World / Primary Cells by Cluster	BAZ2B SYNE2 ROBO2 EPHA3	7.12e-05	190	52	4	feadd834d843f952aa7ced93899fd1f0868743df
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon-IPC_like\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	BAZ2B SYNE2 ROBO2 EPHA3	7.27e-05	191	52	4	48cffb55c71bb8b34e926fc461fcd345ce43ea00
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3_mon-IPC_like-IPCs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	BAZ2B SYNE2 ROBO2 EPHA3	7.27e-05	191	52	4	e4c1c533771b582e21683dbec6f93a558d865e00
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-IPC_like-IPCs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	BAZ2B SYNE2 ROBO2 EPHA3	7.56e-05	193	52	4	2088f1d210c73f74685492c63065c62ac3f553e9
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-IPC_like\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	BAZ2B SYNE2 ROBO2 EPHA3	7.56e-05	193	52	4	f24bae40f5cbcfece04fbefe4e3de1b88ac90de4
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-IPC_like\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	BAZ2B SYNE2 ROBO2 EPHA3	7.72e-05	194	52	4	3e90be6f5b1c5c83632e62941fb18d6a627ec1b5
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-IPC_like-IPCs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	BAZ2B SYNE2 ROBO2 EPHA3	7.87e-05	195	52	4	da8680a91648843901e456b5faef5e85039ade15
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-IPC_like-IPCs/Immature_PNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	BAZ2B SYNE2 ROBO2 EPHA3	7.87e-05	195	52	4	5e36a881fe2646f5a95d07d7b9265e6ada38730c
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38\|World / Primary Cells by Cluster	BAZ2B SYNE2 ROBO2 EPHA3	8.03e-05	196	52	4	38da0751941adca650fe9b383d9f343153978eb5
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn\|World / Primary Cells by Cluster	BAZ2B SYNE2 ROBO2 EPHA3	8.03e-05	196	52	4	721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM171A1 PLXDC2 ROBO2 EPHA3	8.03e-05	196	52	4	2a885eed52f9b002c7995e11e450c7e8d7ae69e6
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAM171A1 PLXDC2 ROBO2 EPHA3	8.03e-05	196	52	4	14246f00c90741a5f8683f377e22e3a7c99661b9
ToppCell	mLN-B_cell-B_cell_cycling\|mLN / Region, Cell class and subclass	NET1 ACY3 NUP133 CLSPN	8.19e-05	197	52	4	806dddcca85c82bd642008d930c8db16b613d88e
ToppCell	mLN-(2)_B_cell-(24)_B_cell_cycling\|mLN / shred on region, Cell_type, and subtype	NET1 ACY3 NUP133 CLSPN	8.19e-05	197	52	4	70fff2d6723f259e18e7a21d22dc46d71f0759ce
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	PLXDC2 ROBO2 SPATA13 EPHA3	8.19e-05	197	52	4	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	mLN-(5)_Dendritic_cell-(54)_pDC\|mLN / shred on region, Cell_type, and subtype	LILRB2 ACY3 ULK1 PFKFB2	8.51e-05	199	52	4	1e738219784a446ee8b0ddeb408e0050e1929e60
ToppCell	mLN-Dendritic_cell-pDC\|mLN / Region, Cell class and subclass	LILRB2 ACY3 ULK1 PFKFB2	8.51e-05	199	52	4	54f1abb57af7bf8a8b82a38b933f257df3b5d8df
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Neuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	BAZ2B SYNE2 ROBO2 EPHA3	8.68e-05	200	52	4	3d134ae3c48ff4d1849db4fbe44ff73fb6c8c779
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NET1 EGFR SYNE2 MUC16	8.68e-05	200	52	4	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	(54)_pDC\|World / shred on Cell_type and subtype	LILRB2 ULK1 PFKFB2 FHIP1A	9.19e-05	203	52	4	b8ba3e51770ff7b45cd02472f3e63aa4d5816f6f
Disease	1-stearoylglycerol 1-monostearin measurement	SYNE2 KIAA1549	3.05e-06	2	52	2	EFO_0021111
Disease	Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	SYNE2 EMD	3.04e-05	5	52	2	C1450051
Disease	Autosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)	SYNE2 EMD	3.04e-05	5	52	2	C0410190
Disease	Emery-Dreifuss muscular dystrophy	SYNE2 EMD	4.55e-05	6	52	2	cv:C0410189
Disease	Muscular Dystrophy, Emery-Dreifuss	SYNE2 EMD	4.55e-05	6	52	2	C0410189
Disease	X-Linked Emery-Dreifuss Muscular Dystrophy	SYNE2 EMD	6.36e-05	7	52	2	C0751337
Disease	Adenocarcinoma of lung (disorder)	AATK EGFR ULK1 EPHA3	4.81e-04	206	52	4	C0152013
Disease	Carcinoma of lung	EGFR EPHA3	7.53e-04	23	52	2	C0684249
Disease	Intrahepatic Cholangiocarcinoma	EGFR ROBO2	8.20e-04	24	52	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	EGFR ROBO2	8.20e-04	24	52	2	C3805278
Disease	intestinal permeability measurement	AATK GRIN3A	9.64e-04	26	52	2	EFO_0011031
Disease	Cholangiocarcinoma	EGFR ROBO2	9.64e-04	26	52	2	C0206698
Disease	Ovarian Mucinous Adenocarcinoma	AATK ULK1	1.37e-03	31	52	2	C1335167
Disease	Squamous cell carcinoma of lung	EGFR EPHA3	1.46e-03	32	52	2	C0149782

Protein segments in the cluster

Peptide	Gene	Start	Entry
TTQPPRGSIPRQSFF	FAM241B	21	Q96D05
SFTPLSSSNTIRRPR	PFKFB2	466	O60825
RTFTSSFLNSRPTPD	ACY3	71	Q96HD9
IIAPSPQRSRSFSVG	EIF2AK3	711	Q9NZJ5
FSSPVNLSTSGRRTP	BAZ2B	531	Q9UIF8
RSVSAPRFISPASQL	GRM4	686	Q14833
SPRFPRQNSGSTLTF	DNMBP	1371	Q6XZF7
VSPIQTSASPLFRGR	TENT2	61	Q6PIY7
LTTSRTPRFSSPNVI	ASXL1	1266	Q8IXJ9
RPVVPSSRSRFAFSV	IPPK	421	Q9H8X2
SSSPLFQVPRTSGRE	KIAA1549	1876	Q9HCM3
LRRGSSFTFLTPGPN	NET1	46	Q7Z628
FFVTRSSGVQPSPAR	DAB2IP	711	Q5VWQ8
FSETRRIPTEPTFSL	MUC16	9861	Q8WXI7
SAVSSPVLFSPVGRR	NUP133	41	Q8WUM0
FSRRASEFPGPLSVT	FAM171A1	366	Q5VUB5
FSRLQAPIPTVRASS	MCEE	16	Q96PE7
VSLPTRGSTFPRQSR	KIF21B	1196	O75037
SSRAIFSVGPVSPNR	LILRB2	176	Q8N423
TAPISFGFTRTSARR	GPKOW	16	Q92917
SPFFSTSLGILVRTR	GRIN3A	646	Q8TCU5
TPSSTFTGIRPARVV	OXR1	186	Q8N573
LNPTRFGTTVPFTSR	PALS2	361	Q9NZW5
QGFFSSPSTSRTPLL	EGFR	1021	P00533
PVRTQSTPFTGPFIS	FHIP1A	841	Q05DH4
IFGFSVSHTTRNPRP	GUK1	31	Q16774
RTENTIFSSTTLPRP	BCL10	181	O95999
QFSSSNSPRGIIFTR	DHX58	361	Q96C10
RFLPRQFGLTNTTVT	EPHA3	381	P29320
AGPSRAVRQSVTSFP	EMD	111	P50402
FSSIAVPGTSSPRQR	DDI2	96	Q5TDH0
FFSRTTSSPIVLRGT	PKD1L1	791	Q8TDX9
RRFSPSQVPIQTRSF	CAMSAP2	1016	Q08AD1
SLPSVFSLPVSVFRR	RTTN	971	Q86VV8
QGQRPTTTSVIFRPL	SYNPO2L	476	Q9H987
IRGASTPFQFRASSP	TAX1BP1	111	Q86VP1
SRVPGSTRPQRSFLS	SYNE2	6816	Q8WXH0
FITGLTRTNPFSDRT	SYNJ1	1396	O43426
RFTVSPAPTSRFSIT	AATK	1336	Q6ZMQ8
FTFSSPASGRSIRSP	TAF2	1181	Q6P1X5
PTSAASIFFIERRPS	PLXDC2	481	Q6UX71
VPGRVPPSSFSRFSQ	OPRPN	66	Q99935
FRSPSPGLFRASLVS	CLSPN	806	Q9HAW4
TPTQRSPRTSFGSLT	CNKSR1	556	Q969H4
VSARFRPFTFSQSTP	SPATA13	66	Q96N96
RPFTFSQSTPIGLDR	SPATA13	71	Q96N96
SSLDSVPRFFRINPT	TTC41P	316	Q6P2S7
QTSPRRTGFSFPTQE	SORBS3	561	O60504
AFTSSQRPRPTSPFS	ROBO2	1256	Q9HCK4
FSLRFRPASSTFLPV	nan	16	Q8N1Y9
NSVIFRSNSPFPSRV	TCTN3	136	Q6NUS6
ERGPSLSFRSFPVFS	RIPOR1	31	Q6ZS17
PTQFQTPRSSAIRRS	ULK1	451	O75385
SPFVRSGTIVRSQTF	WWC3	896	Q9ULE0
VRSLGRFSSVSSPQP	KIAA1522	331	Q9P206