Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP hydrolysis activity	KIF21B ABCA4 TCP1 MCM2 DNAH7 ATP8A1 CHD5 MACF1 DDX43 MORC3 ATP2B2 KIFC1 DNAH11	6.27e-06	441	130	13	GO:0016887
GeneOntologyMolecularFunction	pyrophosphatase activity	NUDT18 KIF21B ABCA4 GNG8 TCP1 MCM2 DNAH7 EEF2 ATP8A1 RHOBTB1 CHD5 MACF1 DDX43 MORC3 ATP2B2 ENTPD8 KIFC1 DNAH11	8.49e-06	839	130	18	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	NUDT18 KIF21B ABCA4 GNG8 TCP1 MCM2 DNAH7 EEF2 ATP8A1 RHOBTB1 CHD5 MACF1 DDX43 MORC3 ATP2B2 ENTPD8 KIFC1 DNAH11	8.63e-06	840	130	18	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	NUDT18 KIF21B ABCA4 GNG8 TCP1 MCM2 DNAH7 EEF2 ATP8A1 RHOBTB1 CHD5 MACF1 DDX43 MORC3 ATP2B2 ENTPD8 KIFC1 DNAH11	8.63e-06	840	130	18	GO:0016818
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	KIF21B ABCA4 GNG8 TCP1 MCM2 DNAH7 EEF2 ATP8A1 RHOBTB1 CHD5 MACF1 DDX43 MORC3 ATP2B2 ENTPD8 KIFC1 DNAH11	1.16e-05	775	130	17	GO:0017111
GeneOntologyMolecularFunction	prostanoid receptor binding	RPGRIP1 FEM1A	1.26e-04	3	130	2	GO:0031862
GeneOntologyMolecularFunction	ATP-dependent activity	KIF21B ABCA4 TCP1 MCM2 DNAH7 ATP8A1 CHD5 MACF1 DDX43 MORC3 ATP2B2 KIFC1 DNAH11	1.88e-04	614	130	13	GO:0140657
GeneOntologyMolecularFunction	histone H3K27 methyltransferase activity	NSD3 EHMT1	6.20e-04	6	130	2	GO:0046976
Domain	-	ANK2 ANKUB1 ANKRD37 ANKRD26 CASKIN2 ANKRD30A EHMT1 ANKRD28 PLA2G6 TANC1 TNKS2 FEM1A	1.53e-07	248	129	12	1.25.40.20
Domain	ANK	ANK2 ANKUB1 ANKRD37 ANKRD26 CASKIN2 ANKRD30A EHMT1 ANKRD28 PLA2G6 TANC1 TNKS2 FEM1A	1.74e-07	251	129	12	SM00248
Domain	Ankyrin_rpt-contain_dom	ANK2 ANKUB1 ANKRD37 ANKRD26 CASKIN2 ANKRD30A EHMT1 ANKRD28 PLA2G6 TANC1 TNKS2 FEM1A	1.98e-07	254	129	12	IPR020683
Domain	Ankyrin_rpt	ANK2 ANKUB1 ANKRD37 ANKRD26 CASKIN2 ANKRD30A EHMT1 ANKRD28 PLA2G6 TANC1 TNKS2 FEM1A	2.76e-07	262	129	12	IPR002110
Domain	Ank_2	ANK2 ANKRD37 ANKRD26 CASKIN2 ANKRD30A EHMT1 ANKRD28 PLA2G6 TANC1 TNKS2 FEM1A	2.95e-07	215	129	11	PF12796
Domain	Ank	ANK2 ANKRD37 ANKRD26 CASKIN2 ANKRD30A EHMT1 ANKRD28 PLA2G6 TANC1 TNKS2 FEM1A	5.30e-07	228	129	11	PF00023
Domain	ANK_REPEAT	ANK2 ANKRD37 ANKRD26 CASKIN2 ANKRD30A EHMT1 ANKRD28 PLA2G6 TANC1 TNKS2 FEM1A	1.48e-06	253	129	11	PS50088
Domain	ANK_REP_REGION	ANK2 ANKRD37 ANKRD26 CASKIN2 ANKRD30A EHMT1 ANKRD28 PLA2G6 TANC1 TNKS2 FEM1A	1.53e-06	254	129	11	PS50297
Domain	-	ANK2 UNC5B CASP4 IRAK3 NLRP4 NLRP13	4.50e-05	93	129	6	1.10.533.10
Domain	DEATH-like_dom	ANK2 UNC5B CASP4 IRAK3 NLRP4 NLRP13	6.40e-05	99	129	6	IPR011029
Domain	-	BCKDK SACS MORC3	3.37e-04	20	129	3	3.30.565.10
Domain	SAM	CNKSR1 PPFIA3 CASKIN2 SCML1 TNKS2	3.60e-04	88	129	5	SM00454
Domain	HATPase_C	BCKDK SACS MORC3	3.91e-04	21	129	3	IPR003594
Domain	SAM_DOMAIN	CNKSR1 PPFIA3 CASKIN2 SCML1 TNKS2	5.13e-04	95	129	5	PS50105
Domain	SAM	CNKSR1 PPFIA3 CASKIN2 SCML1 TNKS2	5.64e-04	97	129	5	IPR001660
Domain	Ferritin-rel	TRIM45 FTHL17	6.97e-04	6	129	2	IPR012347
Domain	DEATH	ANK2 UNC5B IRAK3	8.34e-04	27	129	3	SM00005
Domain	-	CNKSR1 PPFIA3 CASKIN2 SCML1 TNKS2	8.44e-04	106	129	5	1.10.150.50
Domain	SAM_1	CNKSR1 PPFIA3 CASKIN2 SCML1	1.26e-03	68	129	4	PF00536
Domain	SAM/pointed	CNKSR1 PPFIA3 CASKIN2 SCML1 TNKS2	1.31e-03	117	129	5	IPR013761
Domain	Kinase-like_dom	CDK17 CDK18 MKNK1 TBCK BUB1 MACF1 IRAK3 PRKDC MAPK3 DMD MAP3K19	1.35e-03	542	129	11	IPR011009
Domain	Death	ANK2 UNC5B IRAK3	1.51e-03	33	129	3	PF00531
Domain	ZU5	ANK2 UNC5B	1.65e-03	9	129	2	SM00218
Domain	ZU5	ANK2 UNC5B	2.05e-03	10	129	2	PS51145
Domain	Death_domain	ANK2 UNC5B IRAK3	2.28e-03	38	129	3	IPR000488
Domain	DEATH_DOMAIN	ANK2 UNC5B IRAK3	2.28e-03	38	129	3	PS50017
Domain	ZU5	ANK2 UNC5B	2.99e-03	12	129	2	PF00791
Domain	ZU5_dom	ANK2 UNC5B	2.99e-03	12	129	2	IPR000906
Domain	SAM_2	CNKSR1 PPFIA3 TNKS2	3.25e-03	43	129	3	PF07647
Domain	Dynein_heavy_chain_D4_dom	DNAH7 DNAH11	4.08e-03	14	129	2	IPR024317
Domain	Dynein_HC_stalk	DNAH7 DNAH11	4.08e-03	14	129	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH7 DNAH11	4.08e-03	14	129	2	IPR013602
Domain	DHC_N2	DNAH7 DNAH11	4.08e-03	14	129	2	PF08393
Domain	MT	DNAH7 DNAH11	4.08e-03	14	129	2	PF12777
Domain	AAA_8	DNAH7 DNAH11	4.08e-03	14	129	2	PF12780
Domain	HEAT	DNAAF5 PRKDC TBCD	4.44e-03	48	129	3	PF02985
Domain	DHC_fam	DNAH7 DNAH11	4.69e-03	15	129	2	IPR026983
Domain	Dynein_heavy	DNAH7 DNAH11	4.69e-03	15	129	2	PF03028
Domain	Dynein_heavy_dom	DNAH7 DNAH11	4.69e-03	15	129	2	IPR004273
Domain	TBC	TBC1D2B TBC1D9 TBCK	4.70e-03	49	129	3	SM00164
Domain	Pkinase	CDK17 CDK18 MKNK1 TBCK BUB1 IRAK3 MAPK3 MAP3K19	5.00e-03	381	129	8	PF00069
Domain	TPR-like_helical_dom	RMDN2 TTC21B PDCD11 TANC1 PRKDC FEM1A	5.63e-03	233	129	6	IPR011990
Domain	P-loop_NTPase	KIF21B ABCA4 MCM2 AAGAB DNAH7 EEF2 RHOBTB1 CHD5 DDX43 NLRP4 KIFC1 NLRP13 DNAH11	5.84e-03	848	129	13	IPR027417
Domain	RabGAP-TBC	TBC1D2B TBC1D9 TBCK	5.86e-03	53	129	3	PF00566
Domain	Rab-GTPase-TBC_dom	TBC1D2B TBC1D9 TBCK	6.50e-03	55	129	3	IPR000195
Domain	TBC_RABGAP	TBC1D2B TBC1D9 TBCK	6.50e-03	55	129	3	PS50086
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	RPGRIP1 CDK17 CDK18 INTU RBL1 COBLL1 MCM2 FAAP100 PPP1CB DNAAF5 NF1 SCML1 BUB1 TTC21B ANKRD28 MORC3 CFAP161 SPAG16 ATP2B2 CEP97 TBCD	4.23e-08	1321	135	21	27173435
Pubmed	Neurofibromatosis with male breast cancer--risk factor or co-incidence? Report of two rare cases.	NF1 BRCA1 BRCA2	5.72e-08	3	135	3	25267367
Pubmed	PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family.	CDK17 CDK18 MAPK3	2.28e-07	4	135	3	1437147
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	COBLL1 ANKRD26 WDR59 USP20 TBC1D9 KRBA1 RHOBTB1 SACS TTC21B SLITRK5 MACF1 MORC3	5.51e-07	493	135	12	15368895
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPGRIP1 INTU ANK2 ANKRD26 PPP1CB EEF2 BRCA1 GAR1 SACS CHD5 GPC4 ANKRD30A MACF1 IRAK3 PRKDC DMD PLIN1 PCDHGC3 ATP2B2 ZNF541	7.94e-07	1442	135	20	35575683
Pubmed	High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease.	NF1 BRCA1 BRCA2	1.13e-06	6	135	3	28608929
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CDK17 CDK18 COBLL1 NCKIPSD ANKRD26 CEP192 DNAH7 WDR59 NSD3 NF1 CASKIN2 MACF1 TANC1 MORC3 DOP1B	1.39e-06	861	135	15	36931259
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ANKRD37 CEP192 FAAP100 WDR59 TBC1D9 NSD3 INTS5 SARS2 CHD5 SCN8A EHMT1 PDCD11 PLA2G6 TANC1 PRKDC FEM1A TBCD	1.45e-06	1105	135	17	35748872
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ZDBF2 CEP192 PPP1CB SCML1 ANKRD28 MACF1 TANC1 CEP97	1.71e-06	209	135	8	36779422
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	CDK17 CDK18 TCP1 DISC1 MCM2 CEP192 AAGAB DNAH7 PPP1CB EEF2 GAR1 CHD5 GPC4 PDCD11 MACF1 PRKDC MAPK3	2.56e-06	1153	135	17	29845934
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TBRG4 COBLL1 DNAH7 USP20 TBCD DOP1B	3.03e-06	102	135	6	10231032
Pubmed	Neurofibromin (Nf1) is required for skeletal muscle development.	NF1 MAPK3 DMD	1.23e-05	12	135	3	21478499
Pubmed	Mouse models in tumor suppression.	NF1 BRCA1 BRCA2	1.23e-05	12	135	3	9917000
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	FRMPD4 ANK2 BCKDK SLITRK5 MACF1 TANC1 MAPK3	1.26e-05	197	135	7	36604605
Pubmed	Association of BRCA1/2 mutations with ovarian cancer prognosis: An updated meta-analysis.	BRCA1 BRCA2	1.50e-05	2	135	2	29480828
Pubmed	A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes.	BRCA1 BRCA2	1.50e-05	2	135	2	17924331
Pubmed	Attitudes, knowledge, risk perceptions and decision-making among women with breast and/or ovarian cancer considering testing for BRCA1 and BRCA2 and their spouses.	BRCA1 BRCA2	1.50e-05	2	135	2	12833555
Pubmed	Randomised trial of a decision aid and its timing for women being tested for a BRCA1/2 mutation.	BRCA1 BRCA2	1.50e-05	2	135	2	14735173
Pubmed	Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers.	BRCA1 BRCA2	1.50e-05	2	135	2	16032702
Pubmed	Oral contraceptive use and BRCA penetrance: a case-only study.	BRCA1 BRCA2	1.50e-05	2	135	2	19549808
Pubmed	Prevalence of BRCA1 and BRCA2 Mutations Among Patients With Ovarian, Primary Peritoneal, and Fallopian Tube Cancer in India: A Multicenter Cross-Sectional Study.	BRCA1 BRCA2	1.50e-05	2	135	2	34101484
Pubmed	Olaparib monotherapy in patients with advanced relapsed ovarian cancer and a germline BRCA1/2 mutation: a multistudy analysis of response rates and safety.	BRCA1 BRCA2	1.50e-05	2	135	2	26961146
Pubmed	Predicting BRCA1 and BRCA2 gene mutation carriers: comparison of PENN II model to previous study.	BRCA1 BRCA2	1.50e-05	2	135	2	20512419
Pubmed	Deleterious and ethnic-related BRCA1/2 mutations in tissue and blood of Egyptian colorectal cancer patients and its correlation with human papillomavirus.	BRCA1 BRCA2	1.50e-05	2	135	2	37804357
Pubmed	Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.	BRCA1 BRCA2	1.50e-05	2	135	2	22053997
Pubmed	BRCA mutations in women with inflammatory breast cancer.	BRCA1 BRCA2	1.50e-05	2	135	2	29044548
Pubmed	Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy.	BRCA1 BRCA2	1.50e-05	2	135	2	33834176
Pubmed	Should genetic testing for BRCA1/2 be permitted for minors? Opinions of BRCA mutation carriers and their adult offspring.	BRCA1 BRCA2	1.50e-05	2	135	2	18200524
Pubmed	Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations.	BRCA1 BRCA2	1.50e-05	2	135	2	29298688
Pubmed	Fertility in women with BRCA mutations: a case-control study.	BRCA1 BRCA2	1.50e-05	2	135	2	19200971
Pubmed	Prevalence of BRCA mutations and founder effect in high-risk Hispanic families.	BRCA1 BRCA2	1.50e-05	2	135	2	16030099
Pubmed	Prevalence of BRCA1 and BRCA2 large genomic rearrangements in Tunisian high risk breast/ovarian cancer families: Implications for genetic testing.	BRCA1 BRCA2	1.50e-05	2	135	2	28212807
Pubmed	Genetic counseling impacts decision for prophylactic surgery for patients perceived to be at high risk for breast cancer.	BRCA1 BRCA2	1.50e-05	2	135	2	11448436
Pubmed	Rapid evolution of BRCA1 and BRCA2 in humans and other primates.	BRCA1 BRCA2	1.50e-05	2	135	2	25011685
Pubmed	Breast magnetic resonance imaging for screening high-risk women.	BRCA1 BRCA2	1.50e-05	2	135	2	23928241
Pubmed	Heterozygous BRCA1 and BRCA2 and Mismatch Repair Gene Pathogenic Variants in Children and Adolescents With Cancer.	BRCA1 BRCA2	1.50e-05	2	135	2	35980168
Pubmed	Tubal ligation and risk of ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study.	BRCA1 BRCA2	1.50e-05	2	135	2	11377596
Pubmed	BRCA mutations and risk of prostate cancer in Ashkenazi Jews.	BRCA1 BRCA2	1.50e-05	2	135	2	15131025
Pubmed	Broad BRCA1 and BRCA2 mutational spectrum and high incidence of recurrent and novel mutations in the eastern Spain population.	BRCA1 BRCA2	1.50e-05	2	135	2	20033483
Pubmed	Health survey and assessment of the polymorphisms BRCA1/P871L, BRCA1/Q356R, and BRCA2/N372H in female gas station workers in Rio de Janeiro.	BRCA1 BRCA2	1.50e-05	2	135	2	28862356
Pubmed	BRCA1 and BRCA2 germline mutations in Moroccan breast/ovarian cancer families: novel mutations and unclassified variants.	BRCA1 BRCA2	1.50e-05	2	135	2	22425665
Pubmed	BRCA1/2 in high-risk African American women with breast cancer: providing genetic testing through various recruitment strategies.	BRCA1 BRCA2	1.50e-05	2	135	2	18752448
Pubmed	Peritoneal washing cytology in patients with BRCA1 or BRCA2 mutations undergoing risk-reducing salpingo-oophorectomies: a 10-year experience and reappraisal of its clinical utility.	BRCA1 BRCA2	1.50e-05	2	135	2	22425664
Pubmed	Identification of BRCA1/2 founder mutations in Southern Chinese breast cancer patients using gene sequencing and high resolution DNA melting analysis.	BRCA1 BRCA2	1.50e-05	2	135	2	22970155
Pubmed	Anti-müllerian hormone levels and antral follicle count in women with a BRCA1 or BRCA2 germline pathogenic variant: A retrospective cohort study.	BRCA1 BRCA2	1.50e-05	2	135	2	34304065
Pubmed	Absence of 185delAG and 6174delT Mutations among Breast Cancer Patients of Eastern India.	BRCA1 BRCA2	1.50e-05	2	135	2	26625823
Pubmed	Novel germline mutations and unclassified variants of BRCA1 and BRCA2 genes in Chinese women with familial breast/ovarian cancer.	BRCA1 BRCA2	1.50e-05	2	135	2	26852015
Pubmed	Meta-analysis of BRCA1 and BRCA2 penetrance.	BRCA1 BRCA2	1.50e-05	2	135	2	17416853
Pubmed	Power spectral analysis of mammographic parenchymal patterns for breast cancer risk assessment.	BRCA1 BRCA2	1.50e-05	2	135	2	18175183
Pubmed	Presence of crown-like structures in breast adipose tissue; differences between healthy controls, BRCA1/2 gene mutation carriers and breast cancer patients.	BRCA1 BRCA2	1.50e-05	2	135	2	38057686
Pubmed	Germline mutations in BRCA1 and BRCA2 in epithelial ovarian cancer patients in Brazil.	BRCA1 BRCA2	1.50e-05	2	135	2	27914478
Pubmed	BRCA1 and BRCA2 germline mutations in Korean breast cancer patients at high risk of carrying mutations.	BRCA1 BRCA2	1.50e-05	2	135	2	16455195
Pubmed	The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial.	BRCA1 BRCA2	1.50e-05	2	135	2	23810788
Pubmed	Prognostic Impact of Breast-Conserving Therapy Versus Mastectomy of BRCA1/2 Mutation Carriers Compared With Noncarriers in a Consecutive Series of Young Breast Cancer Patients.	BRCA1 BRCA2	1.50e-05	2	135	2	29727326
Pubmed	Risk reducing surgery with peritoneal staging in BRCA1-2 mutation carriers. A prospective study.	BRCA1 BRCA2	1.50e-05	2	135	2	35871032
Pubmed	Recurrent BRCA1 and BRCA2 mutations in breast cancer patients of African ancestry.	BRCA1 BRCA2	1.50e-05	2	135	2	22739995
Pubmed	The impact of a panel of 18 SNPs on breast cancer risk in women attending a UK familial screening clinic: a case-control study.	BRCA1 BRCA2	1.50e-05	2	135	2	27794048
Pubmed	Breast cancer surgery trend changes since the introduction of BRCA1/2 mutation screening: a retrospective cohort analysis of 158 mutation carriers treated at a single institution.	BRCA1 BRCA2	1.50e-05	2	135	2	20972632
Pubmed	BRCA1 and BRCA2 germline mutations in Korean ovarian cancer patients.	BRCA1 BRCA2	1.50e-05	2	135	2	19499246
Pubmed	Comprehensive mutational analysis of BRCA1/BRCA2 for Korean breast cancer patients: evidence of a founder mutation.	BRCA1 BRCA2	1.50e-05	2	135	2	19656164
Pubmed	Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers.	BRCA1 BRCA2	1.50e-05	2	135	2	15986445
Pubmed	Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: the national Israeli study of ovarian cancer.	BRCA1 BRCA2	1.50e-05	2	135	2	18165636
Pubmed	Large genomic rearrangements in BRCA1 and BRCA2: implications for patient care.	BRCA1 BRCA2	1.50e-05	2	135	2	23615136
Pubmed	Clinicopathologic features and BRCA mutations in primary fallopian tube cancer in Japanese women.	BRCA1 BRCA2	1.50e-05	2	135	2	29982601
Pubmed	Breast cancer detection and tumor characteristics in BRCA1 and BRCA2 mutation carriers.	BRCA1 BRCA2	1.50e-05	2	135	2	28343309
Pubmed	BRCA1 and BRCA2 genetic testing in Hispanic patients: mutation prevalence and evaluation of the BRCAPRO risk assessment model.	BRCA1 BRCA2	1.50e-05	2	135	2	17925560
Pubmed	Intratumor Heterogeneity of Homologous Recombination Deficiency in Primary Breast Cancer.	BRCA1 BRCA2	1.50e-05	2	135	2	27601588
Pubmed	Tamoxifen and risk of contralateral breast cancer for BRCA1 and BRCA2 mutation carriers.	BRCA1 BRCA2	1.50e-05	2	135	2	23918944
Pubmed	Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms.	BRCA1 BRCA2	1.50e-05	2	135	2	33558422
Pubmed	Breast cancer risk associated with BRCA1/2 variants in the Pakistani population.	BRCA1 BRCA2	1.50e-05	2	135	2	30430339
Pubmed	Satisfaction with prophylactic risk-reducing salpingo-oophorectomy in BRCA mutation carriers is very high and little dependent on the participants' characteristics at surgery: a prospective study.	BRCA1 BRCA2	1.50e-05	2	135	2	33534430
Pubmed	BRCA 1, 2 mutation and earlier menopause: could BRCA 1,2 be used as predictor of menopause?	BRCA1 BRCA2	1.50e-05	2	135	2	34137566
Pubmed	BRCA1/2 Mutation Detection in the Tumor Tissue from Selected Polish Patients with Breast Cancer Using Next Generation Sequencing.	BRCA1 BRCA2	1.50e-05	2	135	2	33918338
Pubmed	Effect of Oophorectomy on Survival After Breast Cancer in BRCA1 and BRCA2 Mutation Carriers.	BRCA1 BRCA2	1.50e-05	2	135	2	26181175
Pubmed	Mutational analysis of BRCA1 and BRCA2 in Mediterranean Spanish women with early-onset breast cancer: identification of three novel pathogenic mutations.	BRCA1 BRCA2	1.50e-05	2	135	2	14517958
Pubmed	Better life expectancy in women with BRCA2 compared with BRCA1 mutations is attributable to lower frequency and later onset of ovarian cancer.	BRCA1 BRCA2	1.50e-05	2	135	2	18559571
Pubmed	BRCA1-2 diagnostic workflow from next-generation sequencing technologies to variant identification and final report.	BRCA1 BRCA2	1.50e-05	2	135	2	27225819
Pubmed	BRCA1 and BRCA2 mutation prevalence and clinical characteristics of a population-based series of ovarian cancer cases from Denmark.	BRCA1 BRCA2	1.50e-05	2	135	2	18559594
Pubmed	Characterization of BRCA1 and BRCA2 genetic variants in a cohort of Bahraini breast cancer patients using next-generation sequencing.	BRCA1 BRCA2	1.50e-05	2	135	2	31131559
Pubmed	The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.	BRCA1 BRCA2	1.50e-05	2	135	2	11981002
Pubmed	Identification of twenty-nine novel germline unclassified variants of BRCA1 and BRCA2 genes in 1400 Italian individuals.	BRCA1 BRCA2	1.50e-05	2	135	2	29020660
Pubmed	An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions.	BRCA1 BRCA2	1.50e-05	2	135	2	21934105
Pubmed	T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse.	PRKDC DMD	1.50e-05	2	135	2	17668421
Pubmed	Revertant mosaicism for family mutations is not observed in BRCA1/2 phenocopies.	BRCA1 BRCA2	1.50e-05	2	135	2	28199346
Pubmed	Results of a population-based screening for hereditary breast cancer in a region of North-Central Italy: contribution of BRCA1/2 germ-line mutations.	BRCA1 BRCA2	1.50e-05	2	135	2	18092194
Pubmed	Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians.	BRCA1 BRCA2	1.50e-05	2	135	2	16541324
Pubmed	Investigating the relationship between BRCA1 and BRCA2 genes methylation profile and sperm DNA fragmentation in infertile men.	BRCA1 BRCA2	1.50e-05	2	135	2	31095775
Pubmed	Ethnic-specificity, evolution origin and deleteriousness of Asian BRCA variation revealed by over 7500 BRCA variants derived from Asian population.	BRCA1 BRCA2	1.50e-05	2	135	2	36385461
Pubmed	Screening for Genetic Testing in Breast Cancer - Are We Missing the Full Picture?	BRCA1 BRCA2	1.50e-05	2	135	2	26254840
Pubmed	Contribution of BRCA1 germ-line mutations to breast cancer in Greece: a hospital-based study of 987 unselected breast cancer cases.	BRCA1 BRCA2	1.50e-05	2	135	2	19491894
Pubmed	Young age at first pregnancy does protect against early onset breast cancer in BRCA1 and BRCA2 mutation carriers.	BRCA1 BRCA2	1.50e-05	2	135	2	29116468
Pubmed	BRCA1 and BRCA2 mutations in males with familial breast and ovarian cancer syndrome. Results of a Spanish multicenter study.	BRCA1 BRCA2	1.50e-05	2	135	2	26026974
Pubmed	Etiology of familial breast cancer with undetected BRCA1 and BRCA2 mutations: clinical implications.	BRCA1 BRCA2	1.50e-05	2	135	2	24306927
Pubmed	[Germline mutations in the BRCA1 and BRCA2 genes from breast cancer families in China Han people].	BRCA1 BRCA2	1.50e-05	2	135	2	15059511
Pubmed	The impact of reproductive life on breast cancer risk in women with family history or BRCA mutation.	BRCA1 BRCA2	1.50e-05	2	135	2	27880720
Pubmed	BRCA1 and BRCA2 mutations in Turkish familial and non-familial ovarian cancer patients: a high incidence of mutations in non-familial cases.	BRCA1 BRCA2	1.50e-05	2	135	2	12112655
Pubmed	Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer?	BRCA1 BRCA2	1.50e-05	2	135	2	22339411
Pubmed	Risks of breast and ovarian cancer for women harboring pathogenic missense variants in BRCA1 and BRCA2 compared with those harboring protein truncating variants.	BRCA1 BRCA2	1.50e-05	2	135	2	34906479
Pubmed	Validation of Version 3.0 of the Breast Cancer Genetics Referral Screening Tool (B-RST™).	BRCA1 BRCA2	1.50e-05	2	135	2	29740170
Pubmed	Elevated expression of Ki-67 identifies aggressive prostate cancers but does not distinguish BRCA1 or BRCA2 mutation carriers.	BRCA1 BRCA2	1.50e-05	2	135	2	20043088
Interaction	PFN1 interactions	ANK2 COBLL1 TBC1D2B ANKRD26 MCM2 CEP192 NBAS NF1 ATP8A1 BRCA1 CHD5 ANKRD28 MACF1 TANC1 MAPK3 CEP97 ZNF541 DOP1B	4.87e-09	509	130	18	int:PFN1
Interaction	BRCA1 interactions	UBR1 RPGRIP1 PSAP TCP1 RBL1 ANKRD26 MCM2 FAAP100 PPP1CB SMTN TRIM45 EEF2 NF1 BRCA1 GAR1 BRCA2 ANKRD28 PRKDC MAPK3 MORC3 TNKS2 KIFC1	1.54e-05	1249	130	22	int:BRCA1
Interaction	C19orf38 interactions	OMA1 TBC1D9 DNAAF5 NF1 PRKDC ATP2B2	1.98e-05	86	130	6	int:C19orf38
Interaction	PLK1 interactions	MCM2 USP20 TBC1D9 DNAAF5 KRBA1 BRCA1 BRCA2 SACS SCML1 BUB1 ANKRD28 PRKDC CEP97	2.65e-05	510	130	13	int:PLK1
GeneFamily	Ankyrin repeat domain containing	ANK2 ANKUB1 ANKRD37 ANKRD26 CASKIN2 ANKRD30A EHMT1 ANKRD28 PLA2G6 TANC1 TNKS2 FEM1A	1.84e-09	242	87	12	403
GeneFamily	Sterile alpha motif domain containing	CNKSR1 PPFIA3 CASKIN2 SCML1 TNKS2	6.57e-05	88	87	5	760
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	INTU ANKUB1 ANKRD26 SLC9C2 DNAH7 NPAP1 DMD CPLANE1 DNAH11	9.57e-09	197	135	9	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	droplet-Lung-nan-18m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COBLL1 PAPOLB TENT5C NBAS RHOBTB1 SCN8A PLA2G6 CEP97	3.74e-08	163	135	8	5efecdd8a069a822bc9d35b407092925a865e629
ToppCell	droplet-Lung-nan-18m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COBLL1 PAPOLB TENT5C NBAS RHOBTB1 SCN8A PLA2G6 CEP97	3.74e-08	163	135	8	0d94a427f86e62aba12c397c6d7b8cd297f3a0e5
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAPOLB TENT5C NBAS RHOBTB1 BRCA1 BUB1 SCN8A CEP97	3.93e-08	164	135	8	b92e7c91910d518627376166c6ea9ed333b3d07e
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PAPOLB TENT5C NBAS RHOBTB1 BRCA1 BUB1 SCN8A CEP97	3.93e-08	164	135	8	a1e43c6b3e2553f5604100db6e92bf244b70c36d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRMPD4 SACS SCML1 ANKRD30A ATP2B2 FBN3 DOP1B DNAH11	8.07e-08	180	135	8	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	control-Plasmablast\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CNKSR1 ANK2 ANKRD37 COBLL1 TENT5C BUB1 PNOC	7.33e-07	165	135	7	61063e0ce61bc92d5d1093be8279af03f650720b
ToppCell	droplet-Heart-nan-24m-Hematologic-red_blood_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAGAP RBL1 TENT5C TSPAN33 PCDHGC3	7.63e-07	56	135	5	55337ff90621e1fea4d747ae2559c0fa61b38dce
ToppCell	3'_v3-blood-Myeloid_Dendritic-pDC\|blood / Manually curated celltypes from each tissue	COBLL1 SLC9C2 BRCA2 SLITRK5 DMD FBN3 PNOC	1.36e-06	181	135	7	66d890a105f955dca91d6e5e6c730d1a68ee9233
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	RBL1 CEP192 BRCA1 BRCA2 BUB1 TBCD KIFC1	1.88e-06	190	135	7	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	UBR1 NBAS ATP8A1 TBCK MACF1 PRKDC DOP1B	1.95e-06	191	135	7	9454f642c3621370fa23640b631301346b300950
ToppCell	COVID-19_Moderate-Plasmablast\|COVID-19_Moderate / disease group, cell group and cell class	CNKSR1 COBLL1 TENT5C BUB1 MCEE CEP97 PNOC	2.02e-06	192	135	7	25c6c7a244190f82c7feab874bdec12490b7de4d
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	RBL1 CEP192 BRCA1 BRCA2 BUB1 TBCD KIFC1	2.09e-06	193	135	7	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell	COVID-19_Severe-Plasmablast\|COVID-19_Severe / disease group, cell group and cell class	CNKSR1 COBLL1 TENT5C BUB1 MCEE CEP97 PNOC	2.09e-06	193	135	7	8074bcede261b85f9ae03ee372bd6d4b40384537
ToppCell	Transverse-B_cell-B_cell_cycling\|B_cell / Region, Cell class and subclass	GNG8 RBL1 MCM2 CEP192 RHOBTB1 BRCA1 KIFC1	2.56e-06	199	135	7	170ae68963d31f3b821b6f0e8f0c039bea0bc981
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKUB1 SLC9C2 DNAH7 CFAP161 MAP3K19 DNAH11	7.90e-06	155	135	6	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKUB1 SLC9C2 DNAH7 CFAP161 MAP3K19 DNAH11	7.90e-06	155	135	6	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA4 SLC9C2 ATP8A1 PLIN1 MAP3K19	1.23e-05	98	135	5	ffe21b3681fdeaf4a8447bd2b13772d03cdd45aa
ToppCell	390C-Myeloid-Dendritic-cDC_proliferating_1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	MCM2 BRCA1 BRCA2 BUB1 SLITRK5 KIFC1	1.43e-05	172	135	6	6fcc16f1067672967ecbcdfdc727649ae9891dd9
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CAPN9 FRMPD4 IGFBP4 BRCA1 BRCA2 MACF1	1.63e-05	176	135	6	cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c05-MZB1-XBP1\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CNKSR1 COBLL1 TENT5C BUB1 ANKRD30A PNOC	1.74e-05	178	135	6	6765c6970b1f2b719a20d2afd7471e1c262f3fc4
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-Plasma_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CNKSR1 COBLL1 TENT5C BUB1 ANKRD30A PNOC	1.74e-05	178	135	6	693f1135d9c5545945e80c7ba3d098afc0ccac29
ToppCell	3'_v3-Lung-Lymphocytic_B_plasma-Plasmablasts\|Lung / Manually curated celltypes from each tissue	CNKSR1 COBLL1 MCM2 BUB1 PNOC KIFC1	1.85e-05	180	135	6	7f6ce04eeeca53aea9b5bbf5889399b31ff5675b
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TAGAP ANKRD37 ZDBF2 IDS TSPAN33 PNOC	2.16e-05	185	135	6	e913c64f9b4873443d88dce270f0b7b6d1b4cbce
ToppCell	ILEUM-inflamed-(5)_Plasma-(5)_IgM_plasma_cells\|(5)_Plasma / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ANKRD37 TENT5C MCM2 EEF2 EHMT1 ANKRD28	2.16e-05	185	135	6	26ea60b6392410fab048f2e406a9860a018429cc
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCA4 EFCAB13 DNAH7 GPC4 SPAG16 DNAH11	2.22e-05	186	135	6	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	COBLL1 PDZK1 WDR59 TBCK GREB1 DMD	2.29e-05	187	135	6	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	ILEUM-inflamed-(5)_IgM_plasma_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ANKRD37 COBLL1 TENT5C EHMT1 ANKRD28 PNOC	2.43e-05	189	135	6	fa9387d120cde6416998234c6ebd0ef74deed768
ToppCell	Int-URO-Lymphocyte-T_NK-T_NK_proliferative\|Int-URO / Disease, Lineage and Cell Type	MCM2 BRCA1 BRCA2 BUB1 SCN8A KIFC1	2.51e-05	190	135	6	005967c540418b85311308072a07c684f4296aef
ToppCell	PBMC-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	RBL1 MCM2 BRCA1 BRCA2 BUB1 PRKDC	2.51e-05	190	135	6	84ee185939bdefb10705b621a70da27701eadcee
ToppCell	COVID-19_Moderate-Plasmablast\|World / disease group, cell group and cell class	CNKSR1 COBLL1 TENT5C BUB1 CEP97 PNOC	2.58e-05	191	135	6	bb28703020c5296b65527094d2e5924348275e58
ToppCell	COVID-19-Lymphoid-Plasma,_B_cells\|COVID-19 / Condition, Lineage and Cell class	CNKSR1 COBLL1 TENT5C BUB1 PNOC KIFC1	2.74e-05	193	135	6	bffd97a73365e1dd23ff3b0320b4860f04ec091a
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TAGAP COBLL1 ZDBF2 TBC1D9 SLITRK5 FEM1A	2.74e-05	193	135	6	08696a99309f5b088692ddac8cca35413b5e810d
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	INTU ANKUB1 DNAH7 CPLANE1 MAP3K19 DNAH11	2.74e-05	193	135	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	severe-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	COBLL1 ZDBF2 TSPAN33 ANKRD28 CEP97 PNOC	2.82e-05	194	135	6	2fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBL1 MCM2 TBC1D9 BRCA1 PLIN1 KIFC1	2.82e-05	194	135	6	effd38e51062b225ecabc7e1c50154e65495d559
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RBL1 MCM2 TBC1D9 BRCA1 BUB1 KIFC1	2.90e-05	195	135	6	c1435e61e4f0cf457f26ae436936048932ceb0db
ToppCell	mild_COVID-19-B_intermediate\|mild_COVID-19 / disease group, cell group and cell class (v2)	TAGAP COBLL1 TBC1D9 TSPAN33 DMD PNOC	3.07e-05	197	135	6	f669500120646f69355a6f920b892a6f2faeab63
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKUB1 ANKRD37 DNAH7 SPAG16 MAP3K19 DNAH11	3.07e-05	197	135	6	d83c61d2b5742e463122e1a98c7197a5b5b3d41b
ToppCell	Sigmoid-B_cell-B_cell_IgG_Plasma\|B_cell / Region, Cell class and subclass	PSAP TAGAP UNC5B COBLL1 FEM1A PCDHGC3	3.16e-05	198	135	6	305d7ae9b070ac7211638a5282374c02bf13af40
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COBLL1 TENT5C MCM2 BRCA1 BUB1 KIFC1	3.16e-05	198	135	6	2d8d4eb21b4fe3cc178b3518b3ea39c2d9650f24
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKUB1 DNAH7 SPAG16 CPLANE1 MAP3K19 DNAH11	3.16e-05	198	135	6	d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCell	severe-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANK2 COBLL1 TBC1D9 TSPAN33 DMD PNOC	3.25e-05	199	135	6	17283d75a2a900369f63ed02996e7ede97f46140
ToppCell	(1)_T_cell-(12)_Th1\|(1)_T_cell / shred on Cell_type and subtype	TCP1 ANKRD37 IDS PPP1CB MYLIP ANKRD28	3.25e-05	199	135	6	15133e0a4ea6cfcc27c1d438d9e854879ea84c30
ToppCell	severe-B_intermediate\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANK2 COBLL1 TBC1D9 TSPAN33 DMD PNOC	3.34e-05	200	135	6	6d0ac3d00400dd5657ee266f7b885381bf790ce1
ToppCell	Transverse-(2)_B_cell-(24)_B_cell_cycling\|Transverse / shred on region, Cell_type, and subtype	GNG8 RBL1 MCM2 CEP192 RHOBTB1 BRCA1	3.34e-05	200	135	6	e3f9736227151f23f0e331eec0a7a15ce464b517
ToppCell	Transverse-B_cell-B_cell_cycling\|Transverse / Region, Cell class and subclass	GNG8 RBL1 MCM2 CEP192 RHOBTB1 BRCA1	3.34e-05	200	135	6	0e270f8019d9f22068ca426d661937262a5cd331
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-T/NK_proliferative\|Int-URO / Disease, condition lineage and cell class	MCM2 BRCA1 BRCA2 BUB1 SCN8A KIFC1	3.34e-05	200	135	6	99acc1ea01288efdd5b166aa20d66735f2bbe543
ToppCell	mild-T/NK_proliferative\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RBL1 MCM2 BRCA1 BRCA2 BUB1 KIFC1	3.34e-05	200	135	6	25b4a1a33348e274bd4457efc0d6faa5421c3d31
ToppCell	Sigmoid-Dendritic_cell-cycling_DCs\|Dendritic_cell / Region, Cell class and subclass	PSAP C6orf89 MKNK1 BRCA1 BUB1 KIFC1	3.34e-05	200	135	6	372fe9018481a4e9ac6ab3af43705a48238c4376
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	HSPB3 SMTN EEF2 GPC4 DMD CPLANE1	3.34e-05	200	135	6	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCell	COVID_vent-Lymphocytic-Proliferative_Lymphocyte-\|COVID_vent / Disease condition, Lineage, Cell class and subclass	MCM2 BRCA1 BRCA2 BUB1 PRKDC KIFC1	3.34e-05	200	135	6	7e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCell	COVID_vent-Lymphocytic-Proliferative_Lymphocyte\|COVID_vent / Disease condition, Lineage, Cell class and subclass	MCM2 BRCA1 BRCA2 BUB1 PRKDC KIFC1	3.34e-05	200	135	6	9775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCell	mild-T/NK_proliferative\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RBL1 MCM2 BRCA1 BRCA2 BUB1 KIFC1	3.34e-05	200	135	6	63cc57b9331459efbb73051d174d198a3568b938
ToppCell	COVID-19_Mild-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	SLC9C2 CHD5 SLITRK5 ANKRD30A TANC1	3.82e-05	124	135	5	5ef9eb806fb2c8ee5aae0a75503d244b08ee10d4
ToppCell	control-Plasmablast\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CNKSR1 ANKRD37 COBLL1 TENT5C PNOC	4.78e-05	130	135	5	9fe3c5be8488d341cff38757daf7856c112410d0
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Slco2a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	OMA1 IGFBP4 MYLIP GPC4 TANC1	5.33e-05	133	135	5	9d7a08170d38ae9b2ff10a0fa505aeb3aae2824d
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	OMA1 IGFBP4 MYLIP GPC4 TANC1	5.53e-05	134	135	5	cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCell	droplet-Heart-nan-24m-Hematologic-erythrocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENT5C BRCA1 PCDHGC3 KIFC1	7.19e-05	73	135	4	30374f4d30519ca8cd9582da1f9f906420e50244
ToppCell	droplet-Heart-HEART-1m-Hematologic-erythrocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENT5C TSPAN33 BRCA1 KIFC1	7.99e-05	75	135	4	f1ad409d1b2c5f23bf2b22137e612d627c041b97
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic-erythrocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENT5C TSPAN33 CHD5 TBCK	9.31e-05	78	135	4	c3360f02624a84930f8b44e12bb6b9aa8284ddc7
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RPGRIP1 CEP192 LDAH PLA2G6 DDX43	1.00e-04	152	135	5	0652ee3443e6fbb679d2c4f326239ae7c803f924
ToppCell	Control-Epithelial_airway-Ciliated_cells-Ciliated\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKUB1 DNAH7 CFAP161 MAP3K19 DNAH11	1.07e-04	154	135	5	4e3bc24043144143842627cacf6f90dda2228910
ToppCell	Control-Epithelial_airway-Ciliated_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKUB1 DNAH7 CFAP161 MAP3K19 DNAH11	1.07e-04	154	135	5	7556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	INTU ANKRD26 DNAH7 BRCA2 DNAH11	1.17e-04	157	135	5	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Hematologic-red_blood_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TENT5C TSPAN33 CHD5 TBCK	1.24e-04	84	135	4	529e270e2974ecc6a2dcdc4dd65f89c88840a58e
ToppCell	normal_Pleural_Fluid-B_lymphocytes-Undetermined\|normal_Pleural_Fluid / Location, Cell class and cell subclass	COBLL1 EEF2 MYLIP NLRP4 PNOC	1.28e-04	160	135	5	5744cd30709f38e84f7ec8893dc19d7a288b465a
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	TENT5C ATP8A1 BUB1 TTC21B TBCD	1.28e-04	160	135	5	8e2b51d7b42e0b6e62641efdbbc73d31561d6a3e
ToppCell	5'-Adult-LymphNode-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANKUB1 COBLL1 TENT5C BUB1 PNOC	1.28e-04	160	135	5	e44b3c74c76b4632ada7f5bd6d09434b02d79743
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COBLL1 EFCAB13 TENT5C TBC1D9 NSD3	1.28e-04	160	135	5	7ad065337ac802de52c15ee715f6b78a3eed0cef
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN9 IDS SARS2 HPS4 POLK	1.47e-04	165	135	5	7c771f22b58989572c939ed127e637ec28dc0dca
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRMPD4 SACS ANKRD30A FBN3 DOP1B	1.47e-04	165	135	5	dc570154baed59ed109e5369589448e075ba66a9
ToppCell	COVID-19_Mild-PLT_0\|COVID-19_Mild / Disease Group and Platelet Clusters	NCKIPSD ANKRD26 DNAAF5 PTPA MACF1	1.47e-04	165	135	5	083a14d3b0162cee4e79f7398b8fb739582b39ff
ToppCell	ICU-SEP-Lymphocyte-B-Plasmablast\|ICU-SEP / Disease, Lineage and Cell Type	CNKSR1 TENT5C BUB1 ANKRD28 PNOC	1.52e-04	166	135	5	98ce43e14133418f676f1c88c001add9e28259a7
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF21B TAGAP MCM2 BRCA1 KIFC1	1.52e-04	166	135	5	21ba5fd755c0fb31ada42a1b5d60bede0153323d
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KIF21B TAGAP TENT5C AAGAB ZNF221	1.60e-04	168	135	5	6c758eb120faf06ff72d157b495e399191c79ec9
ToppCell	5'-Adult-LymphNode-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDK17 COBLL1 TENT5C TBC1D9 CEP97	1.60e-04	168	135	5	f5a18123f84c62211d9279e9c41e90122e4c4895
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COBLL1 TENT5C EHMT1 ANKRD28 PNOC	1.65e-04	169	135	5	0c2384f780ec25710ebb35c0b0df8f4afb53c9b1
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GDAP1 ZDBF2 PPFIA3 PLIN1 PNOC	1.69e-04	170	135	5	941d637cf76918ee4b0a1833abd1a42593cb8b1a
ToppCell	COVID-pDC\|COVID / Condition, Cell_class and T cell subcluster	COBLL1 SLC9C2 SLITRK5 PCDHGC3 PNOC	1.79e-04	172	135	5	3ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OMA1 RBL1 DISC1 BUB1 POLK	1.79e-04	172	135	5	eba1568d4307e91c94fc616549057cbed8df5840
ToppCell	COVID-pDC-\|COVID / Condition, Cell_class and T cell subcluster	COBLL1 SLC9C2 SLITRK5 PCDHGC3 PNOC	1.79e-04	172	135	5	a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCell	BL-critical-LOC-Lymphoid-PC\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	COBLL1 TENT5C BUB1 PNOC KIFC1	1.84e-04	173	135	5	90700a876d997f7c0f7b3899dffcda7fdafee547
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBL1 MCM2 TSPAN33 BRCA1 DNAH11	1.84e-04	173	135	5	15af4a0f7516dbf5c93ba66a19aca073ebe30d04
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MCM2 TBC1D9 RPL7L1 HPS4 BUB1	1.89e-04	174	135	5	09b091e24317c3f7bac043f04762a533e30793de
ToppCell	367C-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MCM2 TRIM45 BRCA2 IRAK3 KIFC1	1.94e-04	175	135	5	0b1aaa028ba844d4bcb4509fdab8bee648373935
ToppCell	Dividing_Macrophages-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	RBL1 BRCA1 BRCA2 BUB1 KIFC1	1.94e-04	175	135	5	0a8bf455babb3271aa00642199fb58b0b02dc3ac
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDK18 HSPB3 COBLL1 TSPAN33 RHOBTB1	1.94e-04	175	135	5	d4827b4dfad07f11cbdd47fbed287af1afb9b1b8
ToppCell	pdx-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	COBLL1 PDZK1 EFCAB13 WDR59 DMD	1.99e-04	176	135	5	1e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	INTU LRTM1 SMTN BRCA1 DMD	1.99e-04	176	135	5	a8875b4ba4abf6625cdeb67bf544ce1573c59060
ToppCell	COPD-Lymphoid-B_Plasma\|COPD / Disease state, Lineage and Cell class	COBLL1 TENT5C EHMT1 ANKRD28 PNOC	2.04e-04	177	135	5	1b872d3b1e0fca138362098590a634d748dfca60
ToppCell	COVID-19_Moderate-B_intermediate\|COVID-19_Moderate / disease group, cell group and cell class	ANK2 COBLL1 TBC1D9 DMD PNOC	2.04e-04	177	135	5	68e3d12a0c048a2d0f1b9680c7338a35855bba30
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COBLL1 TRIM45 DMD PNOC DNAH11	2.10e-04	178	135	5	812e261d9cbdc74fafe3c5c3422151c1cfacb22d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRMPD4 SACS ANKRD30A FBN3 DNAH11	2.10e-04	178	135	5	51d2188406f04329311b2efd1108fc36617a860e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA1 BRCA2 BUB1 PRKDC KIFC1	2.15e-04	179	135	5	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	NUDT18 DISC1 ANKRD26 TENT5C NBAS	2.15e-04	179	135	5	f378307eb20f002450c748b7be2289d6db2fcbcb
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMPD4 GNMT TBC1D9 CFAP161 SPAG16	2.21e-04	180	135	5	729f0d7af573c7796d8e28e6eec3af2fc0bd33a2
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK18 SMTN GPC4 TANC1 DMD	2.21e-04	180	135	5	f6a05b3751b01e74b2de8440801b0eb2e723c199
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMPD4 GNMT TBC1D9 CFAP161 SPAG16	2.21e-04	180	135	5	9ef79a7c60227e352ac166c7274adb31f585f5ca
ToppCell	droplet-Lung-nan-18m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK18 SMTN GPC4 TANC1 DMD	2.21e-04	180	135	5	dfc75ae4395ff46fbec2c54915d98ead5a1ba1a1
Drug	Ioxaglic acid [59017-64-0]; Down 200; 3.2uM; MCF7; HT_HG-U133A	NUDT18 COBLL1 TENT5C IDS SMTN NF1 PLA2G6 GREB1 MORC3 TNKS2	2.51e-07	197	133	10	3528_DN
Drug	2-propylpentanoic acid; Down 200; 50uM; HL60; HT_HG-U133A	RBL1 IDS INTS5 PTPA NF1 RHOBTB1 MAPK3 CEP97 PNOC	2.25e-06	195	133	9	1163_DN
Drug	Zuclopenthixol hydrochloride [633-59-0]; Down 200; 9.2uM; HL60; HT_HG-U133A	CDK17 ANK2 DISC1 ANKRD26 IDS NF1 SLITRK5 PLA2G6 DDX43	2.34e-06	196	133	9	2936_DN
Drug	ICI 182,780; Down 200; 1uM; MCF7; HT_HG-U133A_EA	NCKIPSD NF1 RHOBTB1 IGFBP4 PDCD11 MACF1 GREB1 DOP1B	1.20e-05	182	133	8	1043_DN
Drug	Etidronic acid, disodium salt [7414-83-7]; Down 200; 16uM; MCF7; HT_HG-U133A	TBC1D2B TENT5C PPFIA3 SMTN RHOBTB1 IGFBP4 GREB1 CEP97	1.51e-05	188	133	8	3325_DN
Drug	Azaguanine-8 [134-58-7]; Down 200; 26.2uM; MCF7; HT_HG-U133A	CNKSR1 ANKRD26 SMTN BRCA1 CASKIN2 GPC4 MACF1 DOP1B	1.90e-05	194	133	8	1670_DN
Drug	Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Down 200; 16.4uM; MCF7; HT_HG-U133A	NUDT18 TENT5C IDS AAGAB USP20 SMTN NF1 GPC4	1.90e-05	194	133	8	2824_DN
Drug	Phensuximide [86-34-0]; Down 200; 21.2uM; MCF7; HT_HG-U133A	UNC5B COBLL1 TENT5C PPFIA3 IDS PTPA MACF1 PLA2G6	1.90e-05	194	133	8	3521_DN
Drug	Gly-His-Lys acetate salt; Down 200; 1uM; MCF7; HT_HG-U133A	TENT5C PPFIA3 AAGAB USP20 SMTN BRCA2 MAPK3 TBCD	1.90e-05	194	133	8	6575_DN
Drug	estradiol, USP; Down 200; 0.1uM; PC3; HT_HG-U133A	CNKSR1 TCP1 PPFIA3 NSD3 ATP8A1 BRCA2 GPC4 TNKS2	2.12e-05	197	133	8	1208_DN
Drug	Isotretinoin [4759-48-2]; Down 200; 13.4uM; MCF7; HT_HG-U133A	COBLL1 ANKRD26 SMTN INTS5 NF1 RHOBTB1 CASKIN2 GREB1	2.12e-05	197	133	8	6017_DN
Drug	Monocrotaline [315-22-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	UNC5B DISC1 COBLL1 ANKRD26 PPFIA3 IDS WDR59 BRCA1	2.12e-05	197	133	8	6771_DN
Drug	Bethanechol chloride [590-63-6]; Down 200; 20.4uM; MCF7; HT_HG-U133A	COBLL1 IDS AAGAB USP20 SMTN NF1 PLA2G6 TNKS2	2.20e-05	198	133	8	3537_DN
Drug	Butylparaben [94-26-8]; Down 200; 20.6uM; MCF7; HT_HG-U133A	ANKRD26 IDS FAAP100 NSD3 SMTN NF1 BUB1 ANKRD28	2.20e-05	198	133	8	6446_DN
Drug	2-propylpentanoic acid; Down 200; 500uM; MCF7; HT_HG-U133A_EA	GDAP1 NCKIPSD AAGAB USP20 TBC1D9 BRCA1 BRCA2 MYLIP	2.20e-05	198	133	8	1020_DN
Drug	Neomycin sulfate [1405-10-3]; Up 200; 4.2uM; PC3; HT_HG-U133A	UNC5B COBLL1 IDS USP20 TBC1D9 HPS4 ATP2B2 TBCD	2.20e-05	198	133	8	2066_UP
Drug	Todralazine hydrochloride [3778-76-5]; Down 200; 14.8uM; MCF7; HT_HG-U133A	ANKRD26 PPFIA3 FAAP100 SMTN HPS4 GPC4 TNKS2 TBCD	2.20e-05	198	133	8	1677_DN
Drug	methoxyacetic acid	CDK18 TBRG4 RBL1 ANKRD37 BCKDK MKNK1 IRAK3 MAPK3 TNKS2	3.25e-05	272	133	9	ctd:C013598
Disease	ductal carcinoma in situ (biomarker_via_orthology)	BRCA1 BRCA2	1.96e-05	2	131	2	DOID:0060074 (biomarker_via_orthology)
Disease	Hereditary site-specific ovarian cancer syndrome	BRCA1 BRCA2	1.96e-05	2	131	2	C4749652
Disease	Intellectual Disability	CNKSR1 FRMPD4 DISC1 BCKDK NF1 BRCA1 SACS SCN8A MACF1 TBCD	3.25e-05	447	131	10	C3714756
Disease	Malignant neoplasm of breast	ABCA4 ANK2 TCP1 PDZK1 EFCAB13 EEF2 NF1 BRCA1 BRCA2 CHD5 ANKRD30A EHMT1 MACF1 DMD ZNF541	8.78e-05	1074	131	15	C0006142
Disease	Prostatic Neoplasms	TCP1 ARID4A PDZK1 GNMT LDAH BRCA1 BRCA2 PRKDC GREB1 MAPK3 POLK	9.94e-05	616	131	11	C0033578
Disease	Malignant neoplasm of prostate	TCP1 ARID4A PDZK1 GNMT LDAH BRCA1 BRCA2 PRKDC GREB1 MAPK3 POLK	9.94e-05	616	131	11	C0376358
Disease	Hereditary breast ovarian cancer syndrome	BRCA1 BRCA2	1.17e-04	4	131	2	cv:C0677776
Disease	Duchenne muscular dystrophy (is_marker_for)	PLA2G6 DMD	1.94e-04	5	131	2	DOID:11723 (is_marker_for)
Disease	hereditary breast ovarian cancer syndrome (is_implicated_in)	BRCA1 BRCA2	1.94e-04	5	131	2	DOID:5683 (is_implicated_in)
Disease	WILMS TUMOR 1	BRCA2 GPC4	2.90e-04	6	131	2	194070
Disease	Wilms tumor 1	BRCA2 GPC4	2.90e-04	6	131	2	cv:CN033288
Disease	Adult only	BRCA1 BRCA2	2.90e-04	6	131	2	C3842001
Disease	Colorectal Carcinoma	OMA1 NPBWR2 ABCA4 ANK2 SMTN NF1 SACS CHD5 BUB1 NPAP1 DMD	3.07e-04	702	131	11	C0009402
Disease	Profound Mental Retardation	CNKSR1 DISC1 NF1 SCN8A TBCD	3.99e-04	139	131	5	C0020796
Disease	Mental Retardation, Psychosocial	CNKSR1 DISC1 NF1 SCN8A TBCD	3.99e-04	139	131	5	C0025363
Disease	Mental deficiency	CNKSR1 DISC1 NF1 SCN8A TBCD	3.99e-04	139	131	5	C0917816
Disease	contrast sensitivity measurement	PDZK1 SPAG16	4.05e-04	7	131	2	EFO_0005419
Disease	Nephroblastoma	BRCA2 GPC4	5.38e-04	8	131	2	cv:C0027708
Disease	Hereditary Wilms tumor	BRCA2 GPC4	5.38e-04	8	131	2	cv:C0677779
Disease	Kidney Wilms tumor	BRCA2 GPC4	5.38e-04	8	131	2	cv:CN305775
Disease	colorectal carcinoma (is_marker_for)	NF1 BRCA1 BRCA2	5.95e-04	37	131	3	DOID:0080199 (is_marker_for)
Disease	waist circumference	OMA1 DISC1 BCKDK GDAP1 TBC1D9 MAPK3 DMD SPAG16	6.83e-04	429	131	8	EFO_0004342
Disease	Pancreatic carcinoma, familial	BRCA1 BRCA2	6.90e-04	9	131	2	C2931038
Disease	Muscle Weakness	DMD TBCD	8.60e-04	10	131	2	C0151786
Disease	Fanconi anemia (is_implicated_in)	BRCA1 BRCA2	8.60e-04	10	131	2	DOID:13636 (is_implicated_in)
Disease	Benign tumor of pancreas	BRCA1 BRCA2	1.48e-03	13	131	2	C0347284
Disease	Ciliopathies	RPGRIP1 TTC21B CPLANE1 DNAH11	1.49e-03	110	131	4	C4277690
Disease	interferon gamma measurement	OMA1 EFCAB13 KRBA1	1.52e-03	51	131	3	EFO_0008165
Disease	Hereditary Breast and Ovarian Cancer Syndrome	BRCA1 BRCA2	1.72e-03	14	131	2	C0677776
Disease	ankle brachial index	NBAS DMD	2.25e-03	16	131	2	EFO_0003912
Disease	cholesterol to total lipids in IDL percentage	COBLL1 MACF1 POLK	2.43e-03	60	131	3	EFO_0022233
Disease	low density lipoprotein cholesterol measurement, body fat percentage	COBLL1 EFCAB13	2.55e-03	17	131	2	EFO_0004611, EFO_0007800
Disease	sphingosine 1-phosphate measurement	OMA1 DMD	2.86e-03	18	131	2	EFO_0800185
Disease	blood metabolite measurement	GNMT PTPA	3.18e-03	19	131	2	EFO_0005664
Disease	Pancreatic carcinoma	BRCA1 BRCA2	3.18e-03	19	131	2	C0235974
Disease	Familial aplasia of the vermis	TTC21B CPLANE1	3.53e-03	20	131	2	cv:C0431399
Disease	Adenocarcinoma of prostate	BRCA1 BRCA2	3.53e-03	20	131	2	C0007112
Disease	response to ketamine	OMA1 IRAK3 TNKS2	3.62e-03	69	131	3	EFO_0009748
Disease	fasting blood insulin measurement	UNC5B COBLL1 MAP3K19	3.62e-03	69	131	3	EFO_0004466
Disease	triglyceride measurement, body fat percentage	COBLL1 PLA2G6	3.89e-03	21	131	2	EFO_0004530, EFO_0007800
Disease	BREAST CANCER	BRCA1 BRCA2	3.89e-03	21	131	2	114480
Disease	stomach cancer (is_implicated_in)	CAPN9 EEF2 BRCA1	4.08e-03	72	131	3	DOID:10534 (is_implicated_in)
Disease	free cholesterol to total lipids in large LDL percentage	COBLL1 MACF1 POLK	4.41e-03	74	131	3	EFO_0022280

Protein segments in the cluster

Peptide	Gene	Start	Entry
VPAQKHLAAEICAEI	TTC21B	876	Q7Z4L5
LIGPETLVCHEVDLD	ARID4A	951	P29374
CEIIHGDIKPDNFIL	BUB1	911	O43683
HLVCLDPELEKAPEG	CHD5	366	Q8TDI0
FAHGVPDLALKDIAC	ABCA4	191	P78363
ICGTVHDEKKPDVLL	CASP4	216	P49662
ALKEIRLEHEEGAPC	CDK18	171	Q07002
LAVEKGDPQLCHFLE	FTHL17	121	Q9BXU8
KCQLDVLDGEHRTPL	ANKRD30A	96	Q9BXX3
PLDLAAFKGHVECVD	ANKRD28	586	O15084
CEADLLKAEPALVAA	DNAH11	3176	Q96DT5
SHLKDELEVPCGLSA	CFAP161	101	Q6P656
GDHCRKLVEPQISEL	DMD	1746	P11532
EKCATILLEHGADPN	ANKRD26	126	Q9UPS8
LTDIHTGKPLDIDEC	FBN3	1711	Q75N90
HEDKPDFVGIICTRL	BCKDK	211	O14874
LIPSLHCAGGEQKEE	DISC1	756	Q9NRI5
LTVKDPICAHGNDDL	COBLL1	671	Q53SF7
IAIKCGIIHPGEDFL	ATP2B2	741	Q01814
VCHTAVPEREGDKII	ATP8A1	486	Q9Y2Q0
CNPEVDGLKHLLETG	ANKRD37	6	Q7Z713
AIDHFSCDAGPLLKI	OR6C2	171	Q9NZP2
EGHLVRVVEKCSPAE	PDZK1	31	Q5T2W1
AILLADLVDSCKPGD	MCM2	396	P49736
PHCLVSEGKELDEDI	ANK2	2851	Q01484
KGADIDALCVAPSHV	PAPOLB	111	Q9NRJ5
GLLHCLKELPEAQDR	KRBA1	271	A5PL33
HNAGERELLECELKP	LRTM1	261	Q9HBL6
LHPKDCGGVLVELEQ	MCEE	161	Q96PE7
LCPEGDIDILLDKFH	GREB1	606	Q4ZG55
EVKEEAGLHCEPETL	NUDT18	91	Q6ZVK8
DAPLHEINGDHLKIC	GPC4	46	O75487
GCLEEALVLIPEAQH	ENTPD8	101	Q5MY95
KHELLEEACRQGLPF	PPFIA3	821	O75145
ICHALLDPDKGTRLE	DOP1B	916	Q9Y3R5
PKEAELLDAAAGIHV	MFI	56	Q8NCR3
HCVKGLVLSLLAEEP	HPS4	546	Q9NQG7
PVSCEKEVDALLHLA	KIFC1	506	Q9BW19
PDGVEIKDLSAVLCH	HSPB3	121	Q12988
LLILGIPDDCKEHEF	PNMA6E	21	A0A0J9YXQ4
VILPSCVEAEAKIHE	MORC3	666	Q14149
EKALKCEEHDVSLPL	GDAP1	46	Q8TB36
GHTKPILCLDATDEL	KIF21B	1306	O75037
KEALLAGHLLCSPEQ	MYLIP	101	Q8WY64
KICDFGLARIADPEH	MAPK3	181	P27361
ECDHLDRLFAPKEAG	NLRP4	131	Q96MN2
DEGLKTLCEALKHPD	NLRP4	821	Q96MN2
KEIRLEHEEGAPCTA	CDK17	221	Q00537
EVLTGCRVVLDDPKH	IRAK3	366	Q9Y616
LPDCKGDQSEHRLAL	GNMT	146	Q14749
PEGAHCKVLVEVVDV	PCDHGC3	331	Q9UN70
LAAGKPRVLCHEAEV	FAAP100	21	Q0VG06
LHDEAVAICLDGQPL	NBAS	2001	A2RRP1
PFGELLCKLVLAVDH	NPBWR2	111	P48146
HLCVALLEGEAKDPC	CASKIN2	171	Q8WXE0
EALLHCGKFQDALEP	MACF1	5341	Q9UPN3
KLHPALDSFDLEVCI	PNOC	31	Q13519
ACRGLDHLEEKIPAL	PLIN1	91	O60240
ICSHLPKDDLIDIAV	INTU	526	Q9ULD6
LLELEAPLKICGDIH	PPP1CB	51	P62140
LLASDPHEALICKSE	BRCA1	431	P38398
VSDIKEEVLAAACHP	BRCA2	726	P51587
LDLHCDKIGPVDHIE	CPLANE1	2731	Q9H799
LLAFCETHAKDDPLV	GNG8	36	Q9UK08
NLPCEADIHTLILDK	CEP97	31	Q8IW35
SIGCVEGLKELVHLE	CEP97	91	Q8IW35
QAAEGIEEPLLHDIC	FRMPD4	726	Q14CM0
IKDECDADLAGALPI	DNAH7	2661	Q8WXX0
LHVVKVLLDCGADPD	FEM1A	561	Q9BSK4
LLVKLLDVPTGDCHI	C17orf80	216	Q9BSJ5
IGIPDLEHALKCLNV	EFCAB13	776	Q8IY85
EELKLPHACCVGIAS	CEP192	1376	Q8TEP8
IAGAGELHLEICLKD	EEF2	546	P13639
GELHANLLCPVDVLD	IDS	176	P22304
LAVDLCGAALAPHLD	DNAAF5	151	Q86Y56
TGKPLLEEEIQHFLC	C6orf89	186	Q6UWU4
PAEQKRLCHTALDDG	CAPN9	301	O14815
IGCVPVDDLEVYLKH	SACS	3466	Q9NZJ4
LVDPKDAEGSTCLHL	EHMT1	831	Q9H9B1
VAAGHEELPLCFALK	DDX43	61	Q9NXZ2
IPAVREEDIDCHGSK	MAP3K19	341	Q56UN5
RLEDKCLELVEHFGP	TBRG4	241	Q969Z0
CLELVEHFGPNELRK	TBRG4	246	Q969Z0
VEIKPGDELLVECHY	MOXD2P	431	A6NHM9
GIAHRDLKPENILCE	MKNK1	206	Q9BUB5
VLLGEFLHPCEDDIV	GAR1	71	Q9NY12
CPEEAAHALELRKGE	SARS2	66	Q9NP81
CPLVDLFRSHEIDGK	SCML1	276	Q9UN30
EVDPAKCVLQGEDLH	TRIM45	396	Q9H8W5
VLTAAHCVEPDIKDL	TPSD1	76	Q9BZJ3
SLCLETLPAHGDEDK	RPGRIP1	601	Q96KN7
LIECQSEGDIKEHPL	TAGAP	21	Q8N103
SEGDIKEHPLLASCE	TAGAP	26	Q8N103
VLCELHDGLLVEAKG	RBL1	251	P28749
VICLEDLIHEIAFPG	RPL7L1	191	Q6DKI1
HPKHCNLLGDELLEC	RIMOC1	116	A6NDU8
PGAALDLCIAAVIKE	NEPRO	31	Q6NW34
VLCDKDGNAIPLSHD	PPM1L	216	Q5SGD2
EALHNFLKAEELCPG	RMDN2	341	Q96LZ7
EVEHPAAKVLCELAD	TCP1	66	P17987
KLEVCELLLGHGAAV	TANC1	1091	Q9C0D5
LHLACRKGDGEILVE	PLA2G6	156	O60733
LDDGAISAHKPLLIC	RHOBTB1	491	O94844
LEPKGELDCHQLADS	IGFBP4	241	P22692
VPFLDALKNHVGELC	INTS5	471	Q6P9B9
KLPCLSVEGDLHTLE	NPAP1	356	Q9NZP6
VLCHLIECNKDVPGI	OMA1	266	Q96E52
ELLHILTDADPEVCK	NCKIPSD	416	Q9NZQ3
LGCKDLDLIFHVALP	TENT5C	86	Q5VWP2
CIKHGFELVELSPEE	AAGAB	131	Q6PD74
KCPIHAAAEAGQLLI	ANKUB1	241	A6NFN9
KTPIDVLCAAVELLH	CNKSR1	106	Q969H4
ALECLPSKEHVDVIA	PDCD11	1751	Q14690
KHAEAALACLAVDPA	TSPAN33	51	Q86UF1
HGRDLDEVSKQELCP	SLITRK5	271	O94991
GHCAPSEAIEKLVAL	PTPA	101	Q15257
QPHKDILVSCGEDRL	SPAG16	361	Q8N0X2
LPKDEKLDGHTDCTL	TBC1D9	301	Q6ZT07
LEALNKHVDECLDGP	POLK	636	Q9UBT6
KLKHRDLEVSCEPDG	ZDBF2	1731	Q9HCK1
EDPDICLEKLKHSGA	UBR1	81	Q8IWV7
LVFIDCPGKLAEHIE	NF1	1706	P21359
CKLADFADALEHPLR	SCN8A	1806	Q9UQD0
ALVEHVKEECDRLGP	PSAP	221	P07602
EEHGCLDIIKELPET	TBCK	231	Q8TEA7
GKEVPLDHEVLLQCR	UNC5B	161	Q8IZJ1
KIDVCIVLLQHGAEP	TNKS2	136	Q9H2K2
DLCPHLDSIGEVTKE	USP20	6	Q9Y2K6
CKDHEKGALVPSALE	NSD3	1386	Q9BZ95
PAVITCDELLLGHEK	PRKDC	4056	P78527
CDELLLGHEKAPAFR	PRKDC	4061	P78527
DIACLLPVHKSLGEL	WDR59	651	Q6PJI9
DLCHVVPAEKKIDEA	YAE1	141	Q9NRH1
LELLHSGLCKFPEVE	ZNF221	6	Q9UK13
LLCGQPADYLVEEKH	SLC9C2	16	Q5TAH2
TEEDHPFAVKLLALC	TBCD	1061	Q9BTW9
LCEGVPKDTLELLHQ	TBC1D2B	386	Q9UPU7
KGLAAHRLEQCEVPE	SMTN	146	P53814
HGLCILKEAPPEEEA	ZNF541	221	Q9H0D2
LDKALEGCSPDHTII	TMPPE	351	Q6ZT21
KEEIPVHEEFILCGG	LDAH	6	Q9H6V9
QDDGIKLLCAALTHP	NLRP13	851	Q86W25