Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhemoglobin beta binding

HBB HBD

5.31e-0521462GO:0031722
DomainARM-type_fold

DCAF1 DNAJC13 CAND1 UBQLN2 UBQLN1 CLASP1 DOCK9 CLASP2 ARMC2 DNAAF5 PSME4 AP3B2 WDFY3

3.12e-0633914813IPR016024
Domain-

DCAF1 DNAJC13 CAND1 CLASP1 CLASP2 ARMC2 DNAAF5 PSME4 AP3B2 WDFY3

1.12e-05222148101.25.10.10
DomainZnf_C2H2-like

ZNF154 ZNF865 ZNF251 CASZ1 ZNF461 ZNF28 GZF1 ZNF608 ZNF45 ZNF451 ZNF790 ZNF638 ZNF749 ZNF84 ZNF860 PRDM15 ZNF583 ZNF124 ZNF646

1.77e-0579614819IPR015880
DomainZnf_C2H2

ZNF154 ZNF865 ZNF251 CASZ1 ZNF461 ZNF28 GZF1 ZNF608 ZNF45 ZNF451 ZNF790 ZNF638 ZNF749 ZNF84 ZNF860 PRDM15 ZNF583 ZNF124 ZNF646

2.06e-0580514819IPR007087
DomainZnF_C2H2

ZNF154 ZNF865 ZNF251 CASZ1 ZNF461 ZNF28 GZF1 ZNF608 ZNF45 ZNF451 ZNF790 ZNF638 ZNF749 ZNF84 ZNF860 PRDM15 ZNF583 ZNF124 ZNF646

2.17e-0580814819SM00355
Domainzf-C2H2

ZNF154 ZNF865 ZNF251 CASZ1 ZNF461 ZNF28 GZF1 ZNF45 ZNF451 ZNF790 ZNF749 ZNF84 ZNF860 PRDM15 ZNF583 ZNF124 ZNF646

3.60e-0569314817PF00096
DomainZINC_FINGER_C2H2_2

ZNF154 ZNF865 ZNF251 CASZ1 ZNF461 ZNF28 GZF1 ZNF608 ZNF45 ZNF451 ZNF790 ZNF749 ZNF84 ZNF860 PRDM15 ZNF583 ZNF124 ZNF646

4.27e-0577514818PS50157
DomainZINC_FINGER_C2H2_1

ZNF154 ZNF865 ZNF251 CASZ1 ZNF461 ZNF28 GZF1 ZNF608 ZNF45 ZNF451 ZNF790 ZNF749 ZNF84 ZNF860 PRDM15 ZNF583 ZNF124 ZNF646

4.42e-0577714818PS00028
DomainARM-like

DCAF1 DNAJC13 CAND1 CLASP1 CLASP2 ARMC2 DNAAF5 PSME4 AP3B2 WDFY3

5.97e-0527014810IPR011989
DomainUbiquilin-1/2

UBQLN2 UBQLN1

6.24e-0521482IPR028430
DomainKRAB

ZNF154 ZNF251 ZNF461 ZNF28 ZNF45 ZNF790 ZNF749 ZNF84 ZNF860 ZNF583 ZNF124

1.36e-0435814811PS50805
DomainKRAB

ZNF154 ZNF251 ZNF461 ZNF28 ZNF45 ZNF790 ZNF749 ZNF84 ZNF860 ZNF583 ZNF124

1.36e-0435814811PF01352
DomainKRAB

ZNF154 ZNF251 ZNF461 ZNF28 ZNF45 ZNF790 ZNF749 ZNF84 ZNF860 ZNF583 ZNF124

1.76e-0436914811SM00349
DomainKRAB

ZNF154 ZNF251 ZNF461 ZNF28 ZNF45 ZNF790 ZNF749 ZNF84 ZNF860 ZNF583 ZNF124

1.81e-0437014811IPR001909
Domainzf-C2H2_6

ZNF154 ZNF865 ZNF251 ZNF461 GZF1 ZNF790 ZNF749 ZNF84 ZNF860 ZNF646

2.06e-0431414810PF13912
DomainHEAT_REPEAT

CAND1 CLASP1 CLASP2 DNAAF5 PSME4

2.34e-04701485PS50077
DomainGlobin-like

HECTD2 HBB HBD

2.53e-04161483IPR009050
DomainGal_mutarotase_SF_dom

MAN2B2 MAN2A1 GALM

3.06e-04171483IPR011013
Domain-

ZNF154 ZNF865 ZNF251 ZNF461 ZNF28 GZF1 ZNF45 ZNF790 ZNF749 ZNF84 ZNF860 PRDM15 ZNF583 ZNF124 ZNF646

3.29e-04679148153.30.160.60
DomainCLASP_N

CLASP1 CLASP2

3.70e-0441482PF12348
DomainCLASP_N_dom

CLASP1 CLASP2

3.70e-0441482IPR024395
DomainZnf_C2H2/integrase_DNA-bd

ZNF154 ZNF865 ZNF251 ZNF461 ZNF28 GZF1 ZNF45 ZNF790 ZNF749 ZNF84 ZNF860 PRDM15 ZNF583 ZNF124 ZNF646

4.14e-0469414815IPR013087
DomainHEAT

CAND1 CLASP1 CLASP2 DNAAF5

5.62e-04481484PF02985
DomainGlyco_hydro_38_C

MAN2B2 MAN2A1

6.14e-0451482IPR011682
DomainAlpha-mann_mid

MAN2B2 MAN2A1

6.14e-0451482PF09261
DomainGlyco_hydro_57/38_cen

MAN2B2 MAN2A1

6.14e-0451482IPR028995
DomainAutophagy-rel_C

ATG2A VPS13B

6.14e-0451482IPR015412
DomainGlyco_hydro_38

MAN2B2 MAN2A1

6.14e-0451482PF01074
DomainHaemoglobin_b

HBB HBD

6.14e-0451482IPR002337
DomainATG_C

ATG2A VPS13B

6.14e-0451482PF09333
Domain-

MAN2B2 MAN2A1

6.14e-04514821.20.1270.50
Domain-

MAN2B2 MAN2A1

6.14e-04514823.20.110.10
DomainAlpha-mann_mid

MAN2B2 MAN2A1

6.14e-0451482SM00872
DomainGlyco_hydro_38_N

MAN2B2 MAN2A1

6.14e-0451482IPR000602
DomainGlyco_hydro_38/57_N

MAN2B2 MAN2A1

6.14e-0451482IPR027291
DomainGlyco_hydro_38_cen

MAN2B2 MAN2A1

6.14e-0451482IPR015341
DomainGlyco_hydro_38C

MAN2B2 MAN2A1

6.14e-0451482PF07748
DomainUbiquilin

UBQLN2 UBQLN1

9.16e-0461482IPR015496
DomainHEAT

CAND1 CLASP1 CLASP2 DNAAF5

1.15e-03581484IPR000357
DomainHECT

NEDD4 HECTD2 HERC1

1.24e-03271483PF00632
DomainHECTc

NEDD4 HECTD2 HERC1

1.24e-03271483SM00119
DomainHECT_dom

NEDD4 HECTD2 HERC1

1.24e-03271483IPR000569
DomainHECT

NEDD4 HECTD2 HERC1

1.24e-03271483PS50237
DomainGlyco_hydro/deAcase_b/a-brl

MAN2B2 MAN2A1

1.28e-0371482IPR011330
DomainChorein_N

ATG2A VPS13B

1.69e-0381482PF12624
DomainVPS13_N

ATG2A VPS13B

1.69e-0381482IPR026854
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DCAF1 CLASP1 DOCK9 ALS2 NEDD4 KANSL1 SETD5 STARD9 ZNF451 OTUD4 MACF1 BOD1L1 VPS13B VCPIP1

3.34e-094071511412693553
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DNAJC13 CAND1 MAN2B2 EPHA6 HACD3 RPS6KB1 L2HGDH CLASP2 ARMC2 CASZ1 PPM1H ZNF461 DNAAF5 ZNF608 RDH11 SETD5 ZNF638 MACF1 AKAP13 RPRD2 BOD1L1 NLGN2 ZNF84 PRDM15 VPS13B

6.59e-0914891512528611215
Pubmed

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

CLASP1 HACD3 SPTA1 RAB11FIP2 SRP68 STARD9 AP3B2 TUBGCP3 MACF1 NLGN2 HBB HBD PCMT1

5.64e-084301511332581705
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

EPRS1 TICRR HACD3 RNF112 ROR1 SRP68 LRRC70 FREM2 FRY EDAR DQX1 PKHD1 KRT20 AKAP13 BOD1L1 PCMT1

1.49e-077361511629676528
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

EPRS1 TICRR DOCK9 RPS6KB1 PAK4 ALS2 CLASP2 SDR39U1 TTBK2 PSME4 SETD5 ZNF638 OTUD4 MACF1 BOD1L1 HERC1 CPLANE1 MGA VPS13B

2.69e-0710841511911544199
Pubmed

Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.

CLASP1 CLASP2 MACF1

7.97e-075151317113391
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

GPBP1 CLASP1 RAB11FIP2 PAK4 ALS2 CLASP2 PPM1H NEDD4 CDCA2 STARD9 NEURL1 XRN1 MACF1 AKAP13 BOD1L1 VCPIP1

1.19e-068611511636931259
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DCAF1 EPRS1 DNAJC13 CAND1 HACD3 SRP68 CDCA2 KANSL1 PSME4 RDH11 TUBGCP3 XRN1 ZNF638 MACF1 AKAP13 WDFY3 MGA RIOK2 ALOX12B PCMT1

1.80e-0613531512029467282
Pubmed

Functional proteomics mapping of a human signaling pathway.

UBQLN2 RMND5A UBQLN1 TENT5A ZNF251 NEDD4 KANSL1 ZNF451 MACF1 HERC1 MMP11 MGA VCPIP1

2.04e-065911511315231748
Pubmed

Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk.

DMBT1 HBB HBD

2.77e-067151317525270
Pubmed

ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity.

CLASP1 CLASP2 MACF1

9.41e-0610151318854161
Pubmed

EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis.

CLASP1 CLASP2 MACF1

9.41e-0610151323001180
Pubmed

A negative regulatory sequence near the mouse beta-maj globin gene associated with a region of potential Z-DNA.

HBB HBD

1.87e-05215126086313
Pubmed

Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain.

HBB HBD

1.87e-052151222203977
Pubmed

Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.

CLASP1 CLASP2

1.87e-052151216914514
Pubmed

A humanized BAC transgenic/knockout mouse model for HbE/beta-thalassemia.

HBB HBD

1.87e-052151216631345
Pubmed

Perturbations in lipid metabolism and gut microbiota composition precede cardiac dysfunction in a mouse model of thalassemia.

HBB HBD

1.87e-052151237902616
Pubmed

Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences.

HBB HBD

1.87e-0521512270684
Pubmed

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.

HBB HBD

1.87e-052151221099112
Pubmed

Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics.

CLASP1 CLASP2

1.87e-052151212837247
Pubmed

A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse beta -globin locus.

HBB HBD

1.87e-052151211121056
Pubmed

The clinical implications of MMP-11 and CK-20 expression in human breast cancer.

KRT20 MMP11

1.87e-052151219914229
Pubmed

A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer.

HBB HBD

1.87e-052151212480689
Pubmed

Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence.

HBB HBD

1.87e-0521512482942
Pubmed

Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.

CLASP1 CLASP2

1.87e-052151216866869
Pubmed

Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity.

HBB HBD

1.87e-052151211830454
Pubmed

Second generation knockout sickle mice: the effect of HbF.

HBB HBD

1.87e-052151211154217
Pubmed

Decreased hepcidin mRNA expression in thalassemic mice.

HBB HBD

1.87e-052151214675418
Pubmed

Nucleotide sequences of the mouse globin beta gene cDNAs in a wild derived new haplotype Hbb(w1).

HBB HBD

1.87e-052151210441738
Pubmed

Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease.

PKHD1 CDC25A

1.87e-052151222155366
Pubmed

Hematopoietic stem cell function in β-thalassemia is impaired and is rescued by targeting the bone marrow niche.

HBB HBD

1.87e-052151232344432
Pubmed

Responses of primary osteoblasts and osteoclasts from hemizygous β-globin knockout thalassemic mice with elevated plasma glucose to 1,25-dihydroxyvitamin D3.

HBB HBD

1.87e-052151231562377
Pubmed

Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells.

CLASP1 CLASP2

1.87e-052151219701196
Pubmed

The complete nucleotide sequence of a beta-globin-like structure, beta h2, from the [Hbb]d mouse BALB/c.

HBB HBD

1.87e-05215126736028
Pubmed

Running exercise alleviates trabecular bone loss and osteopenia in hemizygous β-globin knockout thalassemic mice.

HBB HBD

1.87e-052151224780610
Pubmed

Effects of human gamma-globin in murine beta-thalassaemia.

HBB HBD

1.87e-052151216803575
Pubmed

First report on the co-inheritance of beta-globin IVS-I-5 (G-->C) thalassemia with delta globin CD12 {Asn-->Lys (AAT-->AAA)}HbA₂-NYU in Iran.

HBB HBD

1.87e-052151221194254
Pubmed

A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.

UBQLN2 UBQLN1

1.87e-052151229247619
Pubmed

The adult beta-globin genes of the "single" type mouse C57BL.

HBB HBD

1.87e-05215127237554
Pubmed

Significance of borderline hemoglobin A2 values in an Italian population with a high prevalence of beta-thalassemia.

HBB HBD

1.87e-052151218603555
Pubmed

Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns.

HBB HBD

1.87e-0521512264241
Pubmed

Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine beta-major and beta-minor globin genes.

HBB HBD

1.87e-052151211418464
Pubmed

Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis.

UBQLN2 UBQLN1

1.87e-052151235063704
Pubmed

Hepcidin and 1,25(OH)2D3 effectively restore Ca2+ transport in β-thalassemic mice: reciprocal phenomenon of Fe2+ and Ca2+ absorption.

HBB HBD

1.87e-052151227245334
Pubmed

Co-inheritance of alpha- and beta-thalassaemia in mice ameliorates thalassaemic phenotype.

HBB HBD

1.87e-052151217493845
Pubmed

An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression.

HBB HBD

1.87e-052151228641125
Pubmed

A mouse model for beta 0-thalassemia.

HBB HBD

1.87e-05215128524813
Pubmed

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S.

HBB HBD

1.87e-052151221304105
Pubmed

Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.

HBB HBD

1.87e-052151225616571
Pubmed

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia.

HBB HBD

1.87e-052151230422819
Pubmed

β-Globin cis-elements determine differential nuclear targeting through epigenetic modifications.

HBB HBD

1.87e-052151224297746
Pubmed

Cloning and amplification of alpha and beta mouse globin gene sequences synthesised in vitro.

HBB HBD

1.87e-0521512338418
Pubmed

Nephrectomy Does not Exacerbate Cancellous Bone loss in Thalassemic Mice.

HBB HBD

1.87e-052151232385316
Pubmed

The evolution and sequence comparison of two recently diverged mouse chromosomal beta--globin genes.

HBB HBD

1.87e-0521512519759
Pubmed

Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.

CLASP1 CLASP2

1.87e-052151210899121
Pubmed

Neutralizing the function of a β-globin-associated cis-regulatory DNA element using an artificial zinc finger DNA-binding domain.

HBB HBD

1.87e-052151223074246
Pubmed

Humanized beta-thalassemia mouse model containing the common IVSI-110 splicing mutation.

HBB HBD

1.87e-052151216421096
Pubmed

High phosphate intake induces bone loss in nephrectomized thalassemic mice.

HBB HBD

1.87e-052151235622784
Pubmed

A humanized mouse model for a common beta0-thalassemia mutation.

HBB HBD

1.87e-052151215780748
Pubmed

Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy.

HBB HBD

1.87e-05215127935410
Pubmed

Evolution of the mouse beta-globin genes: a recent gene conversion in the Hbbs haplotype.

HBB HBD

1.87e-05215123870864
Pubmed

Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene.

HBB HBD

1.87e-052151211877258
Pubmed

Molecular characterization of (deltabeta)(0)/beta(0)-thalassemia and (deltabeta)(0)-thalassemia/hemoglobin E in Thai patients.

HBB HBD

1.87e-052151211860449
Pubmed

Tracking of mouse cell lineage using microinjected DNA sequences: analyses using genomic Southern blotting and tissue-section in situ hybridizations.

HBB HBD

1.87e-05215123428512
Pubmed

The molecular characterization of an A:T to G:C transition in the Hbb-b1 gene of the murine homologue of hemoglobin Rainier.

HBB HBD

1.87e-05215121820025
Pubmed

Super-resolution imaging reveals three-dimensional folding dynamics of the β-globin locus upon gene activation.

HBB HBD

1.87e-052151222767512
Pubmed

Transgene copy number-dependent rescue of murine beta-globin knockout mice carrying a 183 kb human beta-globin BAC genomic fragment.

HBB HBD

1.87e-052151215820143
Pubmed

The beta-delta crossover leading to the beta delta hybrid gene of hemoglobin P-Nilotic is located within 54 base-pairs of the 5' end of exon 2 or between codons 31 and 50.

HBB HBD

1.87e-05215123620470
Pubmed

Novel mechanism of hereditary pyropoikilocytosis phenotype due to co-inheritance of β globin and α spectrin mutations.

SPTA1 HBB

1.87e-052151233556202
Pubmed

Model mice for Presbyterian hemoglobinopathy (Asn(beta108)-->Lys) confer hemolytic anemia with altered oxygen affinity and instability of Hb.

HBB HBD

1.87e-052151212127975
Pubmed

The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites.

HBB HBD

1.87e-0521512569555
Pubmed

The chromatin "landscape" of a murine adult β-globin gene is unaffected by deletion of either the gene promoter or a downstream enhancer.

HBB HBD

1.87e-052151224817273
Pubmed

Ligation-mediated amplification of RNA from murine erythroid cells reveals a novel class of beta globin mRNA with an extended 5'-untranslated region.

HBB HBD

1.87e-05215128041612
Pubmed

A 66-base pair insert bridges the deletion responsible for a mouse model of beta-thalassemia.

HBB HBD

1.87e-05215123017971
Pubmed

The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model.

HBB HBD

1.87e-052151233822774
Pubmed

Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model.

HBB HBD

1.87e-052151227959920
Pubmed

Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene.

HBB HBD

1.87e-0521512273235
Pubmed

Mouse haemoglobin beta chains. Comparative sequence data on adult major and minor beta chains from two species, Mus musculus and Mus cervicolor.

HBB HBD

1.87e-0521512999642
Pubmed

Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.

HBB HBD

1.87e-052151222427201
Pubmed

Mild-intensity physical activity prevents cardiac and osseous iron deposition without affecting bone mechanical property or porosity in thalassemic mice.

HBB HBD

1.87e-052151235396390
Pubmed

Heparanase Level and Procoagulant Activity Are Increased in Thalassemia and Attenuated by Janus Kinase 2 Inhibition.

HBB HBD

1.87e-052151232745462
Pubmed

Molecular characterization of a novel homozygous deletion in β-globin cluster causing (δβ)0-Thalassemia among Tunisian family.

HBB HBD

1.87e-052151236214153
Pubmed

The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

HBB HBD

1.87e-0521512728996
Pubmed

Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cells.

HBB HBD

1.87e-052151214615383
Pubmed

CNTO 530 increases expression of HbA and HbF in murine models of β-thalassemia and sickle cell anemia.

HBB HBD

1.87e-052151223157711
Pubmed

HbA2-Partinico or delta(A2)Pro-->Thr, a new genetic variation in the delta-globin gene in cis to the beta(+) thal IVS-I-110 G>A, and the heterogeneity of delta-globin alleles in double heterozygotes for beta- and delta-globin gene defects.

HBB HBD

1.87e-052151219609526
Pubmed

Discovery of a new HBB haplotype w2 in a wild-derived house mouse, Mus musculus.

HBB HBD

1.87e-052151218299925
Pubmed

Hemoglobin induction in mouse macrophages.

HBB HBD

1.87e-052151210359765
Pubmed

Evolution of duplicated beta-globin genes and the structural basis of hemoglobin isoform differentiation in Mus.

HBB HBD

1.87e-052151219675095
Pubmed

Transposition of a long member of the L1 major interspersed DNA family into the mouse beta globin gene locus.

HBB HBD

1.87e-05215122991851
Pubmed

Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes.

NPAS3 NPAS1

1.87e-052151228499489
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

EPRS1 DNAJC13 CLASP1 DOCK9 CLASP2 MACF1

2.13e-05128151630995482
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

TICRR DNAJC13 CAND1 CLASP1 HACD3 SRP68 WDR43 CDCA2 XRN1 KCTD20 MACF1 FKBP3 PCMT1

2.92e-057591511335915203
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

DCAF1 EPRS1 DNAJC13 HACD3 RNF112 XRN1 AKAP13

3.06e-05202151733005030
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

EPRS1 CAND1 UBQLN2 UBQLN1 ZNF251 FRY SACS HECTD2 ZNF451 MACF1 ZNF84 WDFY3 TBC1D23 UROD CARS2 ZNF583 VCPIP1

4.61e-0512851511735914814
Pubmed

A mouse model of β-thalassemia shows a liver-specific down-regulation of Abcc6 expression.

HBB HBD

5.60e-053151221281810
Pubmed

An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis.

HBB HBD

5.60e-053151217607360
Pubmed

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice.

HBB HBD

5.60e-053151228151426
Pubmed

Oxygen affinity of hemoglobin regulates O2 consumption, metabolism, and physical activity.

HBB HBD

5.60e-053151212458204
Pubmed

Developmental expression of mouse stromelysin-3 mRNA.

PLAU MMP11

5.60e-05315127743938
InteractionMAP1LC3A interactions

DCAF1 EPRS1 SYNPO2 UBQLN2 UBQLN1 ATG2A NEDD4 TMEM132C AKAP13 WDFY3 CARS2

1.73e-0624114811int:MAP1LC3A
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF154 ZNF865 ZNF251 CASZ1 ZNF461 ZNF28 GZF1 ZNF608 ZNF45 ZNF451 ZNF790 ZNF749 ZNF84 ZNF860 PRDM15 ZNF583 ZNF124 ZNF646

1.05e-08718891828
GeneFamilyUbiquilin family

UBQLN2 UBQLN1

2.37e-045892783
GeneFamilyMannosidases alpha class 2

MAN2B2 MAN2A1

2.37e-0458921194
GeneFamilyHemoglobin subunits

HBB HBD

1.05e-0310892940
GeneFamilyOTU domain containing

OTUD4 VCPIP1

3.11e-0317892669
GeneFamilyAminoacyl tRNA synthetases, Class I

EPRS1 CARS2

3.88e-0319892131
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

DNAJC13 CAND1 MAN2A1 CLASP1 DOCK9 ROR1 CLASP2 WDR43 NEDD4 PSME4 SACS ZNF451 TUBGCP3 ZNF638 OTUD4 MACF1 AKAP13 WDFY3 VPS13B PCMT1

1.14e-0785615120M4500
CoexpressionDAZARD_UV_RESPONSE_CLUSTER_G6

CLASP1 DOCK9 ZNF451 TUBGCP3 ZNF638 OTUD4 VPS13B

2.18e-051451517M1810
CoexpressionGSE13484_12H_UNSTIM_VS_YF17D_VACCINE_STIM_PBMC_UP

RMND5A RPS6KB1 PSME4 RDH11 SACS MACF1 VPS13B ZNF124

2.18e-052001518M3271
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#5_top-relative-expression-ranked_500

RMND5A CLASP1 ROR1 CLASP2 SETD5 HECTD2 ERCC6L2 OTUD4 RPRD2 CPLANE1

2.48e-0716514810DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k5_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#2_top-relative-expression-ranked_1000

RMND5A CLASP1 TENT5A ROR1 CLASP2 KANSL1 SETD5 HECTD2 ZNF451 ERCC6L2 OTUD4 RPRD2 CPLANE1

5.67e-0733014813DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k2_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_500

SYNPO2 RMND5A CLASP1 ROR1 NPAS3 CLASP2 ADAMTS5 TMEM132C SETD5 HECTD2 ERCC6L2 OTUD4 RPRD2 CPLANE1

1.82e-0642714814DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000

SYNPO2 RMND5A CLASP1 TENT5A ROR1 NPAS3 CLASP2 ADAMTS5 TMEM132C SYT16 KANSL1 SETD5 HECTD2 ZNF451 ERCC6L2 OTUD4 RPRD2 CPLANE1

1.63e-0581814818DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_B_emap-30374_k-means-cluster#3_top-relative-expression-ranked_1000

S100A1 SYT16 ADAMDEC1 PKHD1 KRT20 RPRD2 TNFAIP2

2.38e-051221487gudmap_developingLowerUrinaryTract_P1_bladder_B_1000_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_1000

SYNPO2 RMND5A CLASP1 TENT5A ROR1 NPAS3 CLASP2 TMEM132C KANSL1 HMCN1 ADAMDEC1 SETD5 ERCC6L2 OTUD4 PLAU CPLANE1 VPS13B

4.83e-0580614817DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000

RMND5A CLASP1 TENT5A CLASP2 KANSL1 SETD5 ERCC6L2 OTUD4 PLAU CPLANE1 VPS13B

5.75e-0536914811DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000

RMND5A TENT5A ROR1 CLASP2 KANSL1 SETD5 ERCC6L2 OTUD4 CPLANE1 VPS13B ZNF646

8.40e-0538514811gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlasDevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_top-relative-expression-ranked_500

SYNPO2 CAND1 ROR1 NPAS3 CDCA2 KANSL1 ADAMDEC1 HECTD2 ERCC6L2 OTUD4 CPLANE1

1.01e-0439314811gudmap_developingKidney_e15.5_Ureteral Smooth Musc_500
CoexpressionAtlasDevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_top-relative-expression-ranked_200

SYNPO2 ROR1 KANSL1 HECTD2 ERCC6L2 OTUD4 CPLANE1

1.55e-041641487gudmap_developingKidney_e15.5_Ureteral Smooth Musc_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000

SYNPO2 CAND1 TENT5A ROR1 NPAS3 CLASP2 ADAMTS5 TMEM132C KANSL1 HMCN1 ERCC6L2 OTUD4 KIAA1958 AKAP13 CPLANE1 ZNF646

1.64e-0480614816gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlasDevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#4_top-relative-expression-ranked_200

KANSL1 ERCC6L2 OTUD4 CPLANE1

1.70e-04401484gudmap_developingKidney_e15.5_Ureteral Smooth Musc_200_k4
ToppCellHealthy/Control-RBC|World / Disease group and Cell class

SPTA1 HBD ZNF251 ADAMDEC1 DQX1 PLAU ZNF749 MMP11 HBB

4.41e-091601529f10871238e7bdf3e1f65a17070000477196e50fe
ToppCellHealthy/Control-RBC|Healthy/Control / Disease group and Cell class

SPTA1 HBD ZNF251 ADAMDEC1 DQX1 PLAU MMP11 HBB

7.39e-0815815281fec4f9affdbfba2e281183b717d4d357d474400
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ANKRD29 EPHA6 NSUN7 PPM1H CDCA2 FREM2 GLDC PKHD1

3.30e-07192152825378b5e4b0cea8415ff125783511fc25a56fc00
ToppCellPCW_07-8.5-Epithelial|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ANKRD29 EPHA6 NSUN7 PPM1H FREM2 FRY GLDC PKHD1

3.57e-071941528f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPBP1 NEDD4 PSME4 HMCN1 XRN1 ZNF638 MACF1

2.50e-061761527749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENT5A NPAS3 ADAMTS5 TMEM132C ZNF608 KLHL14 NPAS1

3.35e-06184152723515c28e1f42aab29cef9e5b4a7f45bda7f5520
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ROR1 ADAMTS5 KANSL1 HMCN1 XRN1 ERCC6L2 CARS2

3.86e-0618815276468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ROR1 ADAMTS5 KANSL1 HMCN1 XRN1 ERCC6L2 CARS2

3.86e-0618815277a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ROR1 ADAMTS5 KANSL1 HMCN1 XRN1 ERCC6L2 CARS2

3.86e-0618815279cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

EPRS1 CAND1 MAN2A1 WDFY3 CPLANE1 MGA VPS13B

4.59e-061931527abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCelldroplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANKRD66 ALS2 F5 SPG21 FRY MCEMP1

6.77e-061341526932b7dd5781b730dcd2ffe43f6e142e3f8630f67
ToppCell3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

ATG2A GLDC PKHD1 MACF1 AKAP13 HERC1

7.07e-061351526ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCellHealthy_donor-RBC|World / disease group, cell group and cell class (v2)

SPTA1 HBD ADAMDEC1 DQX1 MMP11 HBB

1.29e-0515015261e1a497ec4b048f7e9cc12dd5dd9aba7fedca9e1
ToppCellHealthy_donor-RBC|Healthy_donor / disease group, cell group and cell class (v2)

SPTA1 HBD ADAMDEC1 DQX1 MMP11 HBB

1.50e-051541526e080d5104fe6f3f6ef617bbcdccf1332ab7231e1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TICRR ZNF154 CDCA2 KLHL14 HBD ZNF583

1.55e-0515515268b524c65fa5c901f70c7caae4ec7fd2859eaf227
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_low-phase|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TICRR ZNF154 CDCA2 KLHL14 HBD ZNF583

1.55e-0515515267fe8b8c0c8a9e3190cfd52d3934509e6780e1717
ToppCell3'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Paneth|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ROR1 L2HGDH ZNF45 CDADC1 DMBT1 CDC25A

2.00e-051621526768a566e76923323c1f197f60bab472a8784490b
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

NEDD4 FRY CD101 CDADC1 ZNF583 ZNF646

2.89e-051731526b9dee61973559e8c2fef3f2dafd43475b386befb
ToppCellwk_20-22-Hematologic-Meg-ery-Definitive_erythroblast|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

SPTA1 ATG2A PSME4 ZNF451 HERC1 HBB

3.84e-0518215260c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EPHA6 ROR1 ADAMTS5 MEPE TMEM132C PHKA1

3.95e-051831526121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_Erythro-Mega-Erythrocytic_early|lymph-node_spleen / Manually curated celltypes from each tissue

SPTA1 MALRD1 UROD CDC25A HBB HBD

3.95e-0518315260d56e16d4868c752c7557acec212029eb469ed05
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-5_PVALB_TRIM67|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ROR1 NPAS3 PHKA1 ZNF608 PKHD1 NPAS1

4.08e-0518415267f6c8912677764d438ab0555faca344d74c2f483
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell-4|TCGA-Uvea / Sample_Type by Project: Shred V9

MAN2A1 ROR1 PSME4 TNFAIP2 VPS13B VCPIP1

4.08e-0518415269c56753e5e668be888662e4713cf4ce44e6c58fb
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

SYNPO2 TENT5A ROR1 FRY DUSP29 AKAP13

4.08e-051841526ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ANKRD29 PPM1H FREM2 FRY GLDC PKHD1

4.08e-051841526fa4915b0498f3069fd5ef497286445528f75187e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_PRSS8|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANKRD29 TENT5A ROR1 NPAS3 ZNF608 NPAS1

4.20e-0518515264c42bd3cd72f91f4d4ebb849069a03761a2cd662
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MEPE TMEM132C PHKA1 GLDC TNFAIP2 KLHL14

4.20e-051851526f4ac62009c0ad3346e71b809e17727303c4df153
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM132C HMCN1 ADAMDEC1 CD180 MCEMP1

4.31e-051131525ec4b89e727e1b921b9cb17443774955b95814dd4
ToppCell10x5'-Liver-Lymphocytic_B-Naive_B_cells|Liver / Manually curated celltypes from each tissue

MYO7B NSUN7 ZNF608 ZNF860 KLHL14 CD180

4.33e-05186152623efdcedbe67f5e6c59106e052f570cd0338f1c1
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ANKRD29 PPM1H PHKA1 FREM2 GLDC PKHD1

4.46e-051871526db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYNPO2 ROR1 ADAMTS5 TMEM132C HECTD2 NLGN2

4.60e-0518815263177b2c1723268d330d3e9f24f9e24492ace6286
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ANKRD29 PPM1H FREM2 GLDC PKHD1 ZNF860

4.73e-0518915265d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

EPHA6 NSUN7 PPM1H FREM2 FRY PKHD1

4.73e-0518915267659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellPCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

EPHA6 NSUN7 CDCA2 FREM2 GLDC PKHD1

4.73e-051891526c8b8f860aaf6c73863cd79941db6b469c830ef06
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANKRD29 ROR1 FREM2 FRY ZNF608 PKHD1

4.87e-0519015268aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAB11FIP2 ADAMTS5 NEDD4 XRN1 PLAU TNFAIP2

5.02e-0519115267d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

ANKRD29 ROR1 FREM2 MALRD1 ZNF608 PKHD1

5.02e-051911526d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellfacs-GAT|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAN2A1 ADAMTS5 S100A1 SUSD2 PLAU MMP11

5.02e-0519115261f5d1e8c313a8dc83c06d2ee45f369b0ec507fbf
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

MAN2A1 DOCK9 CLASP2 KANSL1 MACF1 HERC1

5.17e-05192152647646d7e4990be85072987f92bf18d52f8da752e
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

GPBP1 ZNF608 ZNF451 HERC1 KLHL14 HBB

5.17e-051921526aee6522d25e012231cdb905ce047295cb64d6e82
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANKRD29 FREM2 MALRD1 ZNF608 PKHD1 AKAP13

5.17e-05192152629f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ANKRD29 EPHA6 PPM1H FREM2 GLDC PKHD1

5.17e-051921526d3634574b2e8d2ded6446969361b70761b331aea
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ANKRD29 NSUN7 PPM1H FREM2 GLDC PKHD1

5.17e-0519215261aa5e4d9b32013a3f272561dcb8377f6805706df
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CASZ1 PPM1H FREM2 GLDC PKHD1 KIAA1958

5.47e-0519415265eaaa81f4b2535f983c424aaef00077089526a5c
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SYNPO2 ROR1 CASZ1 MEPE TMEM132C EDAR

5.47e-051941526fb80a0271ccb1cb3f954ebcf2c5945cb6adb6b8c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ROR1 NPAS3 ADAMTS5 TMEM132C PHKA1 ZNF608

5.47e-051941526e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

GPBP1 PRF1 XRN1 ZNF638 MACF1 HBB

6.13e-0519815264c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCellsevere-Myeloid-Neutrophils_4|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

HBD F5 NSUN7 WDFY3 HBB MCEMP1

6.30e-05199152650242666def13e5d4149c563ae000d6768f086f7
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

CLASP1 CLASP2 KANSL1 WDFY3 HERC1 VPS13B

6.30e-05199152694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HACD3 RAB11FIP2 SYT16 GLDC PKHD1 MACF1

6.30e-0519915263cd6383c50ce342fe5c175e2e50784d634a90e80
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD29 TENT5A ROR1 NPAS3 ZNF608 NPAS1

6.48e-052001526523d799eb315b33b77e02d5b7db63dad8450c4e1
ToppCellSigmoid-(4)_Monocyte|Sigmoid / shred on region, Cell_type, and subtype

MYO7B RNF112 F5 TNFAIP2 WDFY3 MCEMP1

6.48e-0520015267f3920a0434d5199c6c8f0b3064a305bb0d87b60
ToppCellSigmoid-Monocyte-Monocyte|Sigmoid / Region, Cell class and subclass

MYO7B RNF112 F5 TNFAIP2 WDFY3 MCEMP1

6.48e-052001526010ca36970cb8894bdbca08779c0ecf56be22fc9
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-TSPAN12|Neuronal / cells hierarchy compared to all cells using T-Statistic

ANKRD29 TENT5A ROR1 NPAS3 ZNF608 NPAS1

6.48e-052001526e5cef95e563a6e793ade190ce88c999bfa0af460
ToppCellSigmoid-Monocyte|Sigmoid / Region, Cell class and subclass

MYO7B RNF112 F5 TNFAIP2 WDFY3 MCEMP1

6.48e-052001526c41bd6ec0f2262fce5cadb37a400d487e6662f49
ToppCellSigmoid-(4)_Monocyte-(40)_Monocyte|Sigmoid / shred on region, Cell_type, and subtype

MYO7B RNF112 F5 TNFAIP2 WDFY3 MCEMP1

6.48e-052001526576c0a1098e6a934448705de3673ef798fcf1b26
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Sema3e_Kank4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ANKRD29 CASZ1 TMEM132C STARD9 KLHL14

1.00e-04135152554b2aaf8d322e01a3ff6099c2422d68ecccf96b4
DrugPBBs

COQ6 UROD HBB HBD

2.27e-06151494CID000158629
DrugEthyl carbylamine

COQ6 UROD HBB HBD

6.33e-06191494CID004474585
Drugethyl isocyanide

COQ6 UROD HBB HBD

2.00e-05251494CID000012226
Drug5-aminolevulinic acid

EPRS1 RBPJL COQ6 UROD HBB HBD LIPI

3.07e-051351497CID000000137
Drughexabromobenzene

UROD HBB HBD

3.19e-05101493CID000006905
Drugtricapryl(methyl)ammonium

HBB HBD

4.25e-0521492CID011071504
Drugallyl 2,4,6-tribromophenyl ether

HBB HBD

4.25e-0521492CID000076767
Drug1,3,5-tribromobenzene

HBB HBD

4.25e-0521492CID000012279
Drug2-(alpha-hydroxybenzyl)-benzimidazole

HBB HBD

4.25e-0521492CID000005792
DrugNSC-334295

HBB HBD

4.25e-0521492CID000100107
DrugAC1L3OJQ

HBB HBD

4.25e-0521492CID000119294
Drugpentabromobenzene

HBB HBD

4.25e-0521492CID000011854
Drugtribromobenzene

HBB HBD

4.25e-0521492CID000011842
DrugBromkal 73-5 PE

HBB HBD

4.25e-0521492CID000118216
DrugTTAB

UROD HBB HBD

4.36e-05111493CID000014250
Diseaseamyotrophic lateral sclerosis type 15 (implicated_via_orthology)

UBQLN2 UBQLN1

7.27e-0531462DOID:0060206 (implicated_via_orthology)
DiseaseDelta-Beta Thalassemia

HBB HBD

7.27e-0531462C0271985
DiseaseSeptic Phlebitis, Sagittal Sinus

F5 PLAU

7.27e-0531462C0751823
DiseaseSagittal Sinus Thrombophlebitis

F5 PLAU

7.27e-0531462C0751824
Diseasebeta thalassemia (implicated_via_orthology)

HBB HBD

7.27e-0531462DOID:12241 (implicated_via_orthology)
DiseaseSagittal Sinus Thrombosis

F5 PLAU

7.27e-0531462C0338575
Diseasehemoglobin measurement, hemoglobin A2 measurement

HBD HBD

2.41e-0451462EFO_0004509, EFO_0005845
Diseaseglucagon measurement, glucose tolerance test

MACF1 HERC1

3.60e-0461462EFO_0004307, EFO_0008463
Diseasesolute carrier family 22 member 16 measurement

F5 MALRD1

3.60e-0461462EFO_0802079
Diseasehemoglobin E disease

HBD HBD

3.60e-0461462MONDO_0016243
Diseaseamyotrophic lateral sclerosis (implicated_via_orthology)

UBQLN2 UBQLN1 ALS2

4.37e-04301463DOID:332 (implicated_via_orthology)
Diseaseanemia (biomarker_via_orthology)

HBB HBD

5.02e-0471462DOID:2355 (biomarker_via_orthology)
Diseasehereditary spastic paraplegia (is_implicated_in)

L2HGDH SPG21

5.02e-0471462DOID:2476 (is_implicated_in)
DiseaseHematuria

CFHR5 PLAU

8.56e-0491462C0018965
DiseaseInherited neuropathies

SPG21 TTBK2 SACS

1.03e-03401463C0598589
Diseasemean corpuscular hemoglobin concentration

TICRR DNAJC13 RMND5A CLASP1 HACD3 SPTA1 PPM1H TTBK2 ZNF638 OTUD4 MACF1 AKAP13 HBB VPS13B

1.21e-03110514614EFO_0004528
DiseasePosterior Choroidal Artery Infarction

F5 PLAU

1.30e-03111462C0887799
DiseaseCerebral Infarction, Left Hemisphere

F5 PLAU

1.30e-03111462C0751010
DiseaseAnterior Choroidal Artery Infarction

F5 PLAU

1.30e-03111462C0751012
DiseaseCerebral Infarction, Right Hemisphere

F5 PLAU

1.30e-03111462C0751011
DiseaseSubcortical Infarction

F5 PLAU

1.30e-03111462C0751014
DiseaseCerebral Infarction

F5 PLAU

1.30e-03111462C0007785
Diseaseautosomal recessive polycystic kidney disease (biomarker_via_orthology)

PKHD1 CDC25A

1.30e-03111462DOID:0110861 (biomarker_via_orthology)
Diseasefrontotemporal dementia (implicated_via_orthology)

UBQLN2 UBQLN1

1.55e-03121462DOID:9255 (implicated_via_orthology)
DiseaseThromboembolism

F5 PLAU

1.55e-03121462C0040038
DiseaseAcute Cerebrovascular Accidents

F5 CASZ1 PLAU

2.45e-03541463C0751956
Diseaseautosomal recessive polycystic kidney disease (implicated_via_orthology)

PKHD1 CDC25A

2.79e-03161462DOID:0110861 (implicated_via_orthology)
Diseaseidiopathic pulmonary fibrosis

KANSL1 HECTD2 AKAP13

2.86e-03571463EFO_0000768
DiseaseAmyotrophic lateral sclerosis

UBQLN2 ALS2

3.15e-03171462cv:C0002736
DiseaseCerebrovascular accident

F5 CASZ1 PLAU

3.63e-03621463C0038454
Diseasefacial asymmetry measurement

ROR1 NPAS3

3.93e-03191462EFO_0009751
Diseasesusceptibility to vaginal yeast infection measurement

NPAS3 HECTD2 PKHD1

4.14e-03651463EFO_0008412
Diseaseinterstitial lung disease

FCRL6 ZNF815P AKAP13

4.51e-03671463EFO_0004244
Diseasesynophrys measurement

EDAR ZNF608 ERCC6L2

4.70e-03681463EFO_0007906
DiseaseDeep Vein Thrombosis

F5 PLAU

4.80e-03211462C0149871
DiseaseVenous Thrombosis

F5 PLAU

4.80e-03211462C0042487

Protein segments in the cluster

PeptideGeneStartEntry
HHVGQAGLKLLTSGD

LINC00269

131

Q8N2A0
QHGASLSSFLHGVKE

ALS2

751

Q96Q42
LFSTLDGAIKHANFH

CASZ1

1041

Q86V15
EIGHLLGLSHDDSKF

ADAMTS5

411

Q9UNA0
LHHALEEGNMLGNKF

ARMC2

296

Q8NEN0
DKLLSFAENGHFHNL

GZF1

636

Q9H116
GYHKLHQLLTEENAG

AKAP13

211

Q12802
LLKHGANIHDQLYDG

ANKRD29

131

Q8N6D5
AHFAAEAGHLNILKT

ANKRD66

81

B4E2M5
HHLSTAAFNGKDLGS

COQ6

391

Q9Y2Z9
GGEILNETRSFHHKL

GATB

306

O75879
ANLNGIHHFSGKLLA

ANGPTL5

341

Q86XS5
EDLHAGQIALIKHGS

CDADC1

106

Q9BWV3
LRHLNLKGNHFQDGT

CD180

471

Q99467
GHFFQEHLSLDQLSL

ATG2A

26

Q2TAZ0
FKDRDHFQLGSLSHL

AP3B2

616

Q13367
TLELHGENFHAGLKV

RBPJL

401

Q9UBG7
HNGKFLNADVQGIHS

OTUD4

296

Q01804
GHEHTLSNLEFAQKV

HAGHL

171

Q6PII5
SEVFEQHLGGHILQS

NPAS1

131

Q99742
QHLGGHILQSLDGFV

NPAS1

136

Q99742
AQALQLFESHAGHLG

UROD

211

P06132
LLIKSGAHFDATNLH

FEM1C

546

Q96JP0
LLLHNKFATEFVAHG

DCAF1

381

Q9Y4B6
DLHSGALSVGKHFVN

OGFOD3

146

Q6PK18
HREGKFNNTLHLIGE

KIR2DS4

61

P43632
FGQTHQHELKNGGSE

NEDD4

1126

P46934
GHSNEAALILHRKGF

MAN2A1

1061

Q16706
TENVLHFKAQGHGAK

HACD3

36

Q9P035
GFHHLGKRINQELSS

MEPE

46

Q9NQ76
AKSSRGNGHFQGHLL

MGA

2261

Q8IWI9
KEKDLAVHQTGHNSG

L2HGDH

81

Q9H9P8
IFHAGKSQGLHENNI

GPBP1

101

Q86WP2
ALLHELSNDGAHKQF

KCTD20

221

Q7Z5Y7
NLLHHILSGKEFGVE

PHKA1

956

P46020
GSFEHNLTTDLLNHL

KIAA1109

3096

Q2LD37
FQHAHKELSGQGHLA

EDAR

171

Q9UNE0
EILNTGFTIQEKGHH

FREM2

831

Q5SZK8
GFTIQEKGHHILSET

FREM2

836

Q5SZK8
HGYLLNLDKGNHSIT

FREM2

1706

Q5SZK8
GKHTRHGLADLSELQ

HERC1

2281

Q15751
ELAHGLSELLSHEGN

HECTD2

561

Q5U5R9
DAKTGLQVHSNLHAG

ARNTL2

256

Q8WYA1
LFSFHKDGHTLQDRG

FCRL6

146

Q6DN72
GHHIDLSGQLELKSV

CAND1

846

Q86VP6
GHHTSINDLLFGIQA

PRF1

306

P14222
EAVKHGLNGILVSNH

HAO1

246

Q9UJM8
HIQHQLGGFLEKTLS

KANSL1

316

Q7Z3B3
SGAALEKEQHLGLLH

MACF1

511

O94854
LNHQGHVKLTDFGLC

RPS6KB1

226

P23443
AALFSELHRKLHSQG

TUBGCP3

71

Q96CW5
EVDGLHKHLGNTVNV

KRT20

211

P35900
DTDGTGNYLLLTHKH

DQX1

606

Q8TE96
GFSGINNLKHLILSH

LRRC70

271

Q7Z2Q7
GFGLHELLNIHNSAK

HMCN1

271

Q96RW7
DIKHGNTFQIHGVSL

PARP11

251

Q9NR21
GAKHGFTLNHLDSRA

MALRD1

321

Q5VYJ5
HEFLATLNHKEEGSG

BOD1L1

156

Q8NFC6
GKHLQDFHLNGFDHN

GALM

231

Q96C23
NSGSKLLVHLQHDGL

CD101

856

Q93033
FDPSHSDNLLHGLNL

KLHL14

11

Q9P2G3
FTLAFKNQLLADHGH

DOCK9

1411

Q9BZ29
QKLTHNLFEQGDAGH

CPLANE1

2431

Q9H799
LQKAGFTHVLNAAHG

DUSP29

76

Q68J44
EHGSDSFLAEHKLLG

FKBP3

31

Q00688
FVKNGHSESSGLIHL

CFHR5

91

Q9BXR6
LLEKFNSHVDHGTGA

DNAJC13

511

O75165
KDIGLQINFHGDELH

AMDHD1

251

Q96NU7
GESHKQLLNHFGRDF

ALOX12B

31

O75342
ITLAFKNQDHAKGGH

MCEMP1

41

Q8IX19
HLDDQILQLTEGHGF

MAN2B2

121

Q9Y2E5
YSDGRSLHLEKNGNH

CDCA2

836

Q69YH5
LAHGHSSQSLGKFED

KIAA1210

796

Q9ULL0
KSGFHLEHQLSEVAL

FRY

1841

Q5TBA9
AFSDGLAHLDNLKGT

HBD

71

P02042
AFSDGLAHLDNLKGT

HBB

71

P68871
GDLAGILTHALEANH

SDR39U1

196

Q9NRG7
HFGNGKSVDDVLSHF

DNAAF5

236

Q86Y56
GSKEHQGELFGIHNL

ERCC6L2

681

Q5T890
TDGSGKLNLQEFHHL

CAPN3

706

P20807
LGFSNLKLEAHHNCS

DMBT1

1806

Q9UGM3
KDHSSLLQGTLAEHF

RPRD2

1326

Q5VT52
ELGTFHQLFKHLGTE

SACS

3831

Q9NZJ4
LSHHSEGLFQKAIAQ

NLGN2

276

Q8NFZ4
HSHGLQEGKDLFTQR

CDC25A

161

P30304
VHTGFDQHEQKFTGL

PAK4

21

O96013
NGSLDSFLRKHDGHF

EPHA6

756

Q9UF33
LGSILNEFGHHKIDV

METTL24

251

Q5JXM2
EFGHVLGLQHTTAAK

MMP11

216

P24347
LHGEGSQDLSTKVHI

TAS2R50

211

P59544
HLGRIHFHNLQGEKF

RDH11

181

Q8TC12
EKFLTHTHGLLGTLN

SUSD2

586

Q9UGT4
GGASHSELIHNLRKN

PCMT1

6

P22061
LAHHGNGQLRASLKE

CARS2

426

Q9HA77
IQGGTSHHLGQNFSK

EPRS1

1236

P07814
AHRSDALQLGLGKHN

PLAU

106

P00749
TGGLKHEILQSHGQD

RMND5A

36

Q9H871
TLINVFHAHSGKEGD

S100A1

11

P23297
HLEKQRSGLQHGFDS

SYT16

146

Q17RD7
EESNHLLLNGGSHKH

TMEM132C

1006

Q8N3T6
VVHFHGQTLLENGNK

F5

1841

P12259
KNLLKHGASLDNFHF

LIPI

141

Q6XZB0
NSIGNLERHKLIHTG

PRDM15

1066

P57071
HSQGGISVDKLHVLA

NSUN7

401

Q8NE18
NALEQHLHSSKEFVG

SETD5

231

Q9C0A6
FEAHLGSHILQSLDG

NPAS3

146

Q8IXF0
SLHGLHLYKESGLDN

PKHD1

3126

P08F94
KLHHGFGEADALLQV

STARD9

4216

Q9P2P6
DHLQLDKVHLFGASL

SPG21

96

Q9NZD8
LEHLQSKYIGTGHAD

SF3B5

11

Q9BWJ5
IKESQQQHGLRHGDF

SRP68

66

Q9UHB9
KIHDHAQLLSGISFN

ADAMDEC1

301

O15204
TLGHLSSVLGNKFDH

CLASP1

391

Q7Z460
AHLSTVLGNKFDHGA

CLASP2

161

O75122
GTVKSSLDHGDFLHI

ROR1

581

Q01973
CNKEFDNGHLLLGHL

ZNF451

176

Q9Y4E5
NHFHQSFKLGDNKGI

ZNF451

276

Q9Y4E5
ELKSHGFDTLLQNLH

TNFAIP2

456

Q03169
DGHGNFFSVRNLKLH

ZNF815P

101

A8K554
DLSGHQHLFGNLKRG

ZNF865

151

P0CJ78
EHHGIGDLKSNVLSV

TICRR

1471

Q7Z2Z1
LTQAHLDGHQKIQTG

ZNF749

566

O43361
VKLIHNSAGHLNGSA

WDFY3

1366

Q8IZQ1
NKNLEHLTHGGYVES

SYNPO2

101

Q9UMS6
LVVNADGELHLSHNG

NEURL1

401

O76050
GEQHSGKSFLLNHLL

RNF112

176

Q9ULX5
GLGDHDLKVHDSNIY

PPM1H

391

Q9ULR3
KDQDTLSQHGIHDGL

UBQLN1

86

Q9UMX0
RKDNHHLFGSTLLGI

TBC1D23

291

Q9NUY8
GHQGDLSTFLHQEGK

TTBK2

891

Q6IQ55
ETLHGKIAVAHNGEL

PPAT

111

Q06203
GKAFESHQELASHLQ

ZNF646

1591

O15015
HGDHKANVGLNLKFN

XRN1

946

Q8IZH2
IGQTHLLGHQLDSFG

RAB11FIP2

246

Q7L804
LVASEGLFHSHKGLE

SPTA1

296

P02549
GLFHSHKGLERNLAV

SPTA1

301

P02549
QHLDVLTGFHLLDGK

nan

261

Q6ZUG5
SEQLHNVTAFQGKGH

VCPIP1

1016

Q96JH7
IIGDLLQFQGSHKHE

PSME4

896

Q14997
IVKLANHGLIHGDFN

RIOK2

216

Q9BVS4
LSSLQGHIKAHAGEE

ZNF124

246

Q15973
SNSEGDLDGLILKHH

ZNF84

126

P51523
EKHGRAFNHGANLIL

ZNF251

541

Q9BRH9
GKAFISGSDHTQHQL

ZNF790

176

Q6PG37
GHFLKDHLNKNEGLA

ZNF608

851

Q9ULD9
TKLLDGTHQQHGFLS

VPS13B

1436

Q7Z7G8
AGNKHIKDQLGLSFH

ZNF28

131

P17035
VAGNVAHILDSNHGK

TTC37

1216

Q6PGP7
GKAFSGQSTLIHHQA

ZNF860

376

A6NHJ4
KLGFLHQQAAHTGEQ

ZNF154

101

Q13106
LKDQDTLIQHGIHDG

UBQLN2

81

Q9UHD9
SHVLHQDSGLGYKDL

TENT5A

126

Q96IP4
ASNLLAHQRGHTGEK

ZNF45

456

Q02386
GHGTEFNKQKHLEAA

ZNF638

586

Q14966
GSFLAQHQRIHTGEK

ZNF583

336

Q96ND8
GFQLTEHLRLHTGEK

ZNF461

341

Q8TAF7
LHSKLISGGHDNRVN

WDR43

116

Q15061
GLKRAGHQLQHDLFF

GLDC

421

P23378
GDFGSDVSHLNLHKT

GLDC

741

P23378
NLKHLLSEGSHGNLT

KIAA1958

31

Q8N8K9
IAHKQGLSDHLGFSL

MYO7B

1226

Q6PIF6