Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	RFNG LFNG	3.22e-05	3	66	2	GO:0033829
GeneOntologyMolecularFunction	peptidase activity	PRSS8 ZMPSTE24 PRSS16 ADAM15 CAPN1 TMPRSS2 ECEL1 F10 ZUP1 PROC	5.35e-05	654	66	10	GO:0008233
GeneOntologyMolecularFunction	endopeptidase activity	PRSS8 ZMPSTE24 ADAM15 CAPN1 TMPRSS2 ECEL1 F10 PROC	8.34e-05	430	66	8	GO:0004175
GeneOntologyMolecularFunction	serine-type peptidase activity	PRSS8 PRSS16 TMPRSS2 F10 PROC	6.10e-04	207	66	5	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	PRSS8 PRSS16 TMPRSS2 F10 PROC	6.80e-04	212	66	5	GO:0017171
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	2.75e-05	3	63	2	GO:0002879
GeneOntologyBiologicalProcess	acylglycerol acyl-chain remodeling	PNPLA3 DGAT2L6	5.49e-05	4	63	2	GO:0036155
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	5.49e-05	4	63	2	GO:0002877
GeneOntologyBiologicalProcess	scaRNA localization to Cajal body	DKC1 WRAP53	9.13e-05	5	63	2	GO:0090666
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	9.13e-05	5	63	2	GO:0002525
GeneOntologyBiologicalProcess	positive regulation of neuronal action potential	FFAR3 GPR42	1.37e-04	6	63	2	GO:1904457
GeneOntologyBiologicalProcess	response to sucrose	SLC6A1 PNPLA3	1.91e-04	7	63	2	GO:0009744
Domain	Fringe	RFNG LFNG	3.79e-05	3	67	2	IPR017374
Domain	GPR40-rel_orph	FFAR3 GPR42	7.57e-05	4	67	2	IPR013312
Domain	Pept_S1A_FX	F10 PROC	1.26e-04	5	67	2	IPR012224
Domain	Fringe-like	RFNG LFNG	1.26e-04	5	67	2	IPR003378
Domain	Fringe	RFNG LFNG	1.26e-04	5	67	2	PF02434
Domain	EGF_3	ADAM15 CFC1B MUC4 SSPOP F10 PROC	1.96e-04	235	67	6	PS50026
Domain	EGF_1	ADAM15 CFC1B MUC4 SSPOP F10 PROC	3.04e-04	255	67	6	PS00022
Domain	TRYPSIN_SER	PRSS8 TMPRSS2 F10 PROC	3.06e-04	90	67	4	IPR033116
Domain	EGF_2	ADAM15 CFC1B MUC4 SSPOP F10 PROC	3.73e-04	265	67	6	PS01186
Domain	TRYPSIN_HIS	PRSS8 TMPRSS2 F10 PROC	5.12e-04	103	67	4	IPR018114
Domain	TRYPSIN_SER	PRSS8 TMPRSS2 F10 PROC	5.71e-04	106	67	4	PS00135
Domain	TRYPSIN_HIS	PRSS8 TMPRSS2 F10 PROC	5.91e-04	107	67	4	PS00134
Domain	Peptidase_S1A	PRSS8 TMPRSS2 F10 PROC	7.26e-04	113	67	4	IPR001314
Domain	TRYPSIN_DOM	PRSS8 TMPRSS2 F10 PROC	7.75e-04	115	67	4	PS50240
Domain	-	F10 PROC	8.18e-04	12	67	2	4.10.740.10
Domain	Coagulation_fac_subgr_Gla_dom	F10 PROC	8.18e-04	12	67	2	IPR017857
Domain	Tryp_SPc	PRSS8 TMPRSS2 F10 PROC	8.27e-04	117	67	4	SM00020
Domain	Trypsin	PRSS8 TMPRSS2 F10 PROC	9.38e-04	121	67	4	PF00089
Domain	Trypsin_dom	PRSS8 TMPRSS2 F10 PROC	9.38e-04	121	67	4	IPR001254
Domain	Peptidase_S1_PA	PRSS8 TMPRSS2 F10 PROC	9.97e-04	123	67	4	IPR009003
Domain	Gla	F10 PROC	1.12e-03	14	67	2	PF00594
Domain	uDENN	DENND2C DENND1C	1.12e-03	14	67	2	SM00800
Domain	GLA	F10 PROC	1.12e-03	14	67	2	SM00069
Domain	GLA_1	F10 PROC	1.12e-03	14	67	2	PS00011
Domain	GLA_domain	F10 PROC	1.12e-03	14	67	2	IPR000294
Domain	GLA_2	F10 PROC	1.12e-03	14	67	2	PS50998
Domain	uDENN	DENND2C DENND1C	1.29e-03	15	67	2	PF03456
Domain	UDENN	DENND2C DENND1C	1.47e-03	16	67	2	PS50946
Domain	DDENN	DENND2C DENND1C	1.47e-03	16	67	2	PS50947
Domain	VWD	MUC4 SSPOP	1.47e-03	16	67	2	SM00216
Domain	DENN	DENND2C DENND1C	1.47e-03	16	67	2	SM00799
Domain	VWF_type-D	MUC4 SSPOP	1.47e-03	16	67	2	IPR001846
Domain	dDENN	DENND2C DENND1C	1.47e-03	16	67	2	SM00801
Domain	DENN	DENND2C DENND1C	1.47e-03	16	67	2	PF02141
Domain	dDENN_dom	DENND2C DENND1C	1.47e-03	16	67	2	IPR005112
Domain	uDENN_dom	DENND2C DENND1C	1.47e-03	16	67	2	IPR005113
Domain	VWFD	MUC4 SSPOP	1.47e-03	16	67	2	PS51233
Domain	dDENN	DENND2C DENND1C	1.47e-03	16	67	2	PF03455
Domain	DENN	DENND2C DENND1C	1.47e-03	16	67	2	PS50211
Domain	DENN_dom	DENND2C DENND1C	1.47e-03	16	67	2	IPR001194
Domain	VWD	MUC4 SSPOP	1.47e-03	16	67	2	PF00094
Domain	EGF	ADAM15 CFC1B MUC4 F10 PROC	1.55e-03	235	67	5	SM00181
Domain	EMI	EMID1 SSPOP	1.67e-03	17	67	2	PS51041
Domain	EGF-like_dom	ADAM15 CFC1B MUC4 F10 PROC	1.99e-03	249	67	5	IPR000742
Domain	EGF-like_CS	ADAM15 CFC1B MUC4 F10 PROC	2.45e-03	261	67	5	IPR013032
Domain	SRCR	CD163L1 TMPRSS2	2.55e-03	21	67	2	PF00530
Domain	SR	CD163L1 TMPRSS2	3.61e-03	25	67	2	SM00202
Domain	-	CD163L1 TMPRSS2	3.61e-03	25	67	2	3.10.250.10
Domain	SRCR_1	CD163L1 TMPRSS2	3.90e-03	26	67	2	PS00420
Domain	SRCR_2	CD163L1 TMPRSS2	3.90e-03	26	67	2	PS50287
Pathway	WP_VITAMIN_K_METABOLISM_AND_ACTIVATION_OF_DEPENDENT_PROTEINS	VKORC1 F10 PROC	1.48e-05	13	54	3	M45518
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	3.66e-06	2	67	2	25637492
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	3.66e-06	2	67	2	30478340
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	3.66e-06	2	67	2	38040866
Pubmed	In the presence of phospholipids, glycosaminoglycans potentiate factor Xa-mediated protein C activation by modulating factor Xa activity.	F10 PROC	3.66e-06	2	67	2	17343367
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	3.66e-06	2	67	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	3.66e-06	2	67	2	26091414
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	3.66e-06	2	67	2	27550964
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	3.66e-06	2	67	2	35858247
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	3.66e-06	2	67	2	22506074
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	3.66e-06	2	67	2	32073900
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	3.66e-06	2	67	2	24748202
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	3.66e-06	2	67	2	36362376
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	3.66e-06	2	67	2	20399779
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	3.66e-06	2	67	2	19630535
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	3.66e-06	2	67	2	23110765
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	3.66e-06	2	67	2	26522986
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	3.66e-06	2	67	2	14722361
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	3.66e-06	2	67	2	27664183
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	3.66e-06	2	67	2	26260360
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	3.66e-06	2	67	2	37019194
Pubmed	The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control.	SMUG1 DKC1	3.66e-06	2	67	2	23246433
Pubmed	Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks.	RNF8 WRAP53	3.66e-06	2	67	2	27310875
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	1.10e-05	3	67	2	22673524
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	1.10e-05	3	67	2	12496283
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	1.10e-05	3	67	2	23665276
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	1.10e-05	3	67	2	34210970
Pubmed	Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.	RFNG LFNG	1.10e-05	3	67	2	26608918
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	1.10e-05	3	67	2	31719611
Pubmed	Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats.	RFNG LFNG	1.10e-05	3	67	2	16221665
Pubmed	RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks.	RNF8 WRAP53	1.10e-05	3	67	2	33674555
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	1.10e-05	3	67	2	16123168
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	1.10e-05	3	67	2	22493486
Pubmed	Differential expression pattern of the three Fringe genes is associated with epidermal differentiation.	RFNG LFNG	1.10e-05	3	67	2	9804358
Pubmed	Factor Va residues 311-325 represent an activated protein C binding region.	F10 PROC	1.10e-05	3	67	2	17646160
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	1.10e-05	3	67	2	23066016
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	1.10e-05	3	67	2	25581519
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	1.10e-05	3	67	2	22190648
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	1.10e-05	3	67	2	31272808
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	1.10e-05	3	67	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	1.10e-05	3	67	2	29768180
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	1.10e-05	3	67	2	18931303
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	1.10e-05	3	67	2	38524121
Pubmed	Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry.	TMPRSS2 F10	1.10e-05	3	67	2	35294338
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42	1.10e-05	3	67	2	38329121
Pubmed	Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer.	RFNG LFNG	2.19e-05	4	67	2	22624713
Pubmed	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	FFAR3 GPR42	2.19e-05	4	67	2	23401498
Pubmed	Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response.	RNF8 WRAP53	2.19e-05	4	67	2	27715493
Pubmed	Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype.	RFNG LFNG	2.19e-05	4	67	2	19026002
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42	2.19e-05	4	67	2	9344866
Pubmed	Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.	F10 PROC	2.19e-05	4	67	2	18198180
Pubmed	The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair.	RNF8 WRAP53	2.19e-05	4	67	2	25512560
Pubmed	Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis.	RFNG LFNG	2.19e-05	4	67	2	29629872
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42	2.19e-05	4	67	2	21518883
Pubmed	Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va.	F10 PROC	2.19e-05	4	67	2	16935856
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42	2.19e-05	4	67	2	15684720
Pubmed	Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.	FFAR3 GPR42	2.19e-05	4	67	2	29021375
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42	2.19e-05	4	67	2	29644622
Pubmed	Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila.	RFNG LFNG	3.64e-05	5	67	2	9207795
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	FFAR3 GPR42	3.64e-05	5	67	2	19009545
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	FFAR3 GPR42	3.64e-05	5	67	2	24327954
Pubmed	A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis.	DKC1 WRAP53	3.64e-05	5	67	2	19179534
Pubmed	Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.	FFAR3 GPR42	3.64e-05	5	67	2	19047060
Pubmed	Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements.	VKORC1 F10	3.64e-05	5	67	2	16580898
Pubmed	The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1.	RNF8 WRAP53	5.46e-05	6	67	2	26734725
Pubmed	Demarcation of early mammalian cortical development by differential expression of fringe genes.	RFNG LFNG	5.46e-05	6	67	2	10675782
Pubmed	Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.	FFAR3 GPR42	5.46e-05	6	67	2	19460454
Pubmed	Genetic factors contribute to patient-specific warfarin dose for Han Chinese.	VKORC1 PROC	5.46e-05	6	67	2	18680736
Pubmed	Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.	RFNG LFNG	5.46e-05	6	67	2	28089369
Pubmed	An evaluation of nine genetic variants related to metabolism and mechanism of action of warfarin as applied to stable dose prediction.	VKORC1 PROC	5.46e-05	6	67	2	20499136
Pubmed	VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.	VKORC1 F10	7.63e-05	7	67	2	29321368
Pubmed	Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular junctions.	DOK7 ECEL1	7.63e-05	7	67	2	20484637
Pubmed	Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo.	DKC1 WRAP53	7.63e-05	7	67	2	20351177
Pubmed	Cryo-EM structure of substrate-bound human telomerase holoenzyme.	DKC1 WRAP53	7.63e-05	7	67	2	29695869
Pubmed	Purification and characterization of plasma protein C inhibitor.	F10 PROC	7.63e-05	7	67	2	2551064
Pubmed	Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain.	RFNG LFNG	7.63e-05	7	67	2	19479951
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	FFAR3 GPR42	1.02e-04	8	67	2	34626852
Pubmed	Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice.	RFNG LFNG	1.02e-04	8	67	2	12001066
Pubmed	Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients.	VKORC1 PROC	1.02e-04	8	67	2	19794411
Pubmed	Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes.	RFNG LFNG	1.02e-04	8	67	2	10341080
Pubmed	Notch/Delta expression in the developing mouse lung.	RFNG LFNG	1.02e-04	8	67	2	11044610
Pubmed	Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.	RFNG LFNG	1.30e-04	9	67	2	15574878
Pubmed	Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.	RFNG LFNG	1.99e-04	11	67	2	10878608
Pubmed	Defects in somite formation in lunatic fringe-deficient mice.	RFNG LFNG	1.99e-04	11	67	2	9690472
Pubmed	A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway.	RFNG LFNG	1.99e-04	11	67	2	9187150
Pubmed	BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.	CFC1B LFNG	2.81e-04	13	67	2	18550712
Pubmed	Genetic determinants of warfarin dosing in the Han-Chinese population.	VKORC1 PROC	2.81e-04	13	67	2	19958090
Pubmed	The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.	RFNG LFNG	3.28e-04	14	67	2	23806616
Pubmed	BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling.	RFNG LFNG	3.78e-04	15	67	2	16324690
Pubmed	Microbiota modulate sympathetic neurons via a gut-brain circuit.	FFAR3 GPR42	3.78e-04	15	67	2	32641826
Pubmed	HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.	DKC1 WRAP53	3.78e-04	15	67	2	23685356
Pubmed	Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.	RFNG LFNG	3.78e-04	15	67	2	12971992
Pubmed	Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.	RFNG LFNG	3.78e-04	15	67	2	27966429
Pubmed	Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.	RFNG LFNG	3.78e-04	15	67	2	12167404
Pubmed	Expression of Notch pathway components in fetal and adult mouse small intestine.	RFNG LFNG	4.31e-04	16	67	2	12617809
Pubmed	Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.	DKC1 WRAP53	4.31e-04	16	67	2	25416818
Pubmed	KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.	WRAP53 UTY	4.31e-04	16	67	2	35212626
Pubmed	Association of warfarin dose with genes involved in its action and metabolism.	VKORC1 PROC	4.31e-04	16	67	2	17048007
Pubmed	Dyskeratosis Congenita and Related Telomere Biology Disorders	DKC1 WRAP53	4.31e-04	16	67	2	20301779
Pubmed	Lunatic fringe null female mice are infertile due to defects in meiotic maturation.	RFNG LFNG	5.48e-04	18	67	2	15659488
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	VKORC1 SMUG1 PSMA3 SLC25A10 TUT1 SLC7A7 ZUP1	5.61e-04	742	67	7	26871637
Interaction	APOC3 interactions	VKORC1 ZMPSTE24 UTY F10	7.76e-06	40	64	4	int:APOC3
Cytoband	1q42-q43	KCNK1 EXO1	4.39e-05	7	67	2	1q42-q43
Cytoband	22q13.31	PNPLA3 PKDREJ	2.08e-03	46	67	2	22q13.31
GeneFamily	Gla domain containing	F10 PROC	5.73e-04	13	50	2	1250
GeneFamily	Proteases, serine	PRSS8 PRSS16 TMPRSS2	7.03e-04	63	50	3	738
GeneFamily	Beta 3-glycosyltransferases	RFNG LFNG	1.99e-03	24	50	2	426
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND2C DENND1C	2.16e-03	25	50	2	504
Coexpression	GSE14308_TH2_VS_NAIVE_CD4_TCELL_UP	B9D2 PSMA3 SPNS3 NDUFV1 LFNG MVD	1.14e-05	200	66	6	M3364
Coexpression	GSE17301_CTRL_VS_48H_ACD3_ACD28_IFNA2_STIM_CD8_TCELL_DN	EMID1 SLC25A10 MAP3K20 EXO1 TUT1 MVD	1.14e-05	200	66	6	M8039
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 CD163L1 EMID1 EXO1 KCNQ1	8.08e-06	182	67	5	d3a037268f026eb2f84428b1821022503cef7756
ToppCell	BL-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PRSS8 DENND2C KCNK1 TMPRSS2 MUC4	1.02e-05	191	67	5	3f9b8c4fb72ae6f3167b187e6715c4dcb3159f98
ToppCell	CF-Epithelial\|CF / Disease state, Lineage and Cell class	PRSS8 DENND2C KCNK1 TMPRSS2 MUC4	1.07e-05	193	67	5	518901c2e36a79c6189cd0d9e6d36dbd4f56a79c
ToppCell	CF-Epithelial-Epithelial_cell\|CF / Disease state, Lineage and Cell class	PRSS8 DENND2C KCNK1 TMPRSS2 MUC4	1.07e-05	193	67	5	4e3dda27c71b7fdac90d081f0d8e9ca3a8ea7820
ToppCell	CTRL-Epithelial-Epithelial_cell\|CTRL / Disease state, Lineage and Cell class	PRSS8 DENND2C KCNK1 TMPRSS2 MUC4	1.10e-05	194	67	5	2bc4deaf2a01a39809fc323962fce4286835209c
ToppCell	CTRL-Epithelial\|CTRL / Disease state, Lineage and Cell class	PRSS8 DENND2C KCNK1 TMPRSS2 MUC4	1.10e-05	194	67	5	49dcb31427f370692308f939e23992925708abb7
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Satb1_(Substantia_Innominata_(SI))\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	BRS3 TMPRSS2 TRPV6	3.48e-05	42	67	3	f4ce47a88935f1eaa9395791294ae567aac92545
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Satb1_(Substantia_Innominata_(SI))-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	BRS3 TMPRSS2 TRPV6	3.48e-05	42	67	3	14eda1c244cf32cade59fd2f57dd9bc00c97c895
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Satb1_(Substantia_Innominata_(SI))--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	BRS3 TMPRSS2 TRPV6	3.48e-05	42	67	3	f02985b8cdbd858c362766953a8f08ce338e8ce7
ToppCell	normal_Lung-B_lymphocytes-Undetermined\|normal_Lung / Location, Cell class and cell subclass	B9D2 FFAR3 GPR42 DENND2C	9.68e-05	159	67	4	f89fc18966d9b9b33e81e7b9eb3ec3420c20ff43
ToppCell	Healthy_Control-Lymphoid-Plasma\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	ANGPTL6 ACSM5 TUT1 IFT80	1.07e-04	163	67	4	2913ccdd4613472cd82077d4993e1d9f8b223398
ToppCell	Healthy_Control-Lymphoid-Plasma-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	ANGPTL6 ACSM5 TUT1 IFT80	1.07e-04	163	67	4	b589ff57d58dcb215ee3b5a10d81f43e5752a196
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANGPTL6 CD163L1 KCNK1 ZNF865	1.09e-04	164	67	4	467ad12884b70d243988174ae960ee2b7b6cfb0c
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANGPTL6 CD163L1 KCNK1 ZNF865	1.09e-04	164	67	4	4e1861382c9e93856da19303474c8975c19706d2
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CRYBA4 CD163L1 KCNK1 ZNF865	1.17e-04	167	67	4	5d1919bea8e5a52ac6fc953caff15509b7142923
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CRYBA4 CD163L1 KCNK1 ZNF865	1.17e-04	167	67	4	d8f497860d48342a3aaaad328f88e4d55ab4faeb
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK1 PNPLA3 SSPOP PROC	1.17e-04	167	67	4	40d102e01ccbc7262d00fafd59ca5234909009cb
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-like-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PCNX2 B9D2 SMUG1 MVD	1.20e-04	168	67	4	9e7b4b9b977e90e083f5164013e79df8bc2d492e
ToppCell	facs-Tongue-nan-3m-Epithelial-basal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCNX2 OXCT1 DENND2C SPNS3	1.20e-04	168	67	4	ca0c4a819f9047fc40d224f7656fec60f6fa05d8
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TUT1 DNMBP F10 ZUP1	1.20e-04	168	67	4	c3d2d573f21350a4a674faff30b06ff644d00ac3
ToppCell	facs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DGKG SPNS3 ZNF865 F10	1.22e-04	169	67	4	813472d429c0b12580b17b440e00a6d8beb7947f
ToppCell	NS-critical-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DOK7 KCNK1 MUC4 PROC	1.22e-04	169	67	4	aec97583b23112060437b619cb429dc32f29285f
ToppCell	367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	PRSS8 SLC25A10 KCNK1 TMPRSS2	1.31e-04	172	67	4	a9e65201ad9ab4f64251aba2c0bb3d8f9e0193b6
ToppCell	367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|367C / Donor, Lineage, Cell class and subclass (all cells)	PRSS8 SLC25A10 KCNK1 TMPRSS2	1.31e-04	172	67	4	26006967d0c82f7bd9b36a18e97a1b93e856aa67
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 CD163L1 EMID1 EXO1	1.40e-04	175	67	4	9d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l2\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRSS16 KCNK1 EXO1 F10	1.43e-04	176	67	4	1510cdfcfb46ce1196a1220c07fb5f3986c81b78
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KCNK1 TMPRSS2 MUC4 WDR49	1.43e-04	176	67	4	3bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 VKORC1 EMID1 SPNS3	1.46e-04	177	67	4	9b4c1ca5c6fca9a7a936dad49a04155903ef9c32
ToppCell	droplet-Skin-nan-18m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD163L1 DENND1C EMP3 SSPOP	1.49e-04	178	67	4	12d5c6be6cfbf733e3cb02780606b3725eda7d2b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 CD163L1 EMID1 EXO1	1.49e-04	178	67	4	2a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCell	droplet-Skin-nan-18m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD163L1 DENND1C EMP3 SSPOP	1.49e-04	178	67	4	e0769ad06f92423a3cb6c78a61da3ba5bd9b4eae
ToppCell	droplet-Skin-nan-18m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD163L1 DENND1C EMP3 SSPOP	1.49e-04	178	67	4	11c2ce093b7538518c8d4497dc5b0b4da22bf1a8
ToppCell	PBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KLHL21 MAP3K20 KCNQ1 IFT80	1.59e-04	181	67	4	2b9b460239d67fd480cee60820cdb306109d3567
ToppCell	PBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	KLHL21 MAP3K20 KCNQ1 IFT80	1.59e-04	181	67	4	2a1aa4a0ec7bc367857beaff543135e4345c835b
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRSS8 DENND2C KCNK1 MUC4	1.73e-04	185	67	4	f3fbc3096f85397a959cee17c3c4fcf2d511f3d5
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A1 CD163L1 EMID1 EXO1	1.73e-04	185	67	4	0b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCell	facs-Lung-EPCAM-24m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 SLC25A10 KCNK1 TMPRSS2	1.77e-04	186	67	4	3c4994a1a7db06a61da8170e45e06aaef7896592
ToppCell	droplet-Fat-Scat-21m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 TMPRSS2 PROC	1.77e-04	186	67	4	59710cff3f6f7c318ee2524b44c1a909f312c25e
ToppCell	facs-Lung-EPCAM-24m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 SLC25A10 KCNK1 TMPRSS2	1.77e-04	186	67	4	a583d6fc0f1e729f6e9fd18d7b49d6eab9ca32b9
ToppCell	droplet-Fat-Scat-21m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 TMPRSS2 PROC	1.77e-04	186	67	4	de88fafac51049ec1920695844d8ce8057940272
ToppCell	droplet-Fat-Scat-21m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 TMPRSS2 PROC	1.77e-04	186	67	4	7ff73ab8fed5da779ee9c7bd2e14a8363edb7509
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A1 EMID1 KCNK1 ECEL1	1.81e-04	187	67	4	16e55d802fc4e71878305e61ad03806aabd59537
ToppCell	E12.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PRSS8 KCNK1 TMPRSS2 DENND1C	1.81e-04	187	67	4	baff4edc1bf64e3e03864a434fa47075ff7372fd
ToppCell	facs-SCAT-Fat-3m-Epithelial-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 TMPRSS2 PROC	1.81e-04	187	67	4	08f2ecce3c08f35d995187b21bb7407a99dee4c2
ToppCell	facs-SCAT-Fat-3m-Epithelial-epithelial_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 TMPRSS2 PROC	1.81e-04	187	67	4	939a068ac0913b9eeb5da4a9cb267d51cb711999
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-bladder_urothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 EMID1 KCNK1 TMPRSS2	1.81e-04	187	67	4	aa336fb568a24e12c0454265ddd71ed10a6614cf
ToppCell	facs-SCAT-Fat-3m-Epithelial\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 TMPRSS2 PROC	1.81e-04	187	67	4	e02e7f608506b9a48384f07727944f1cb8f7c575
ToppCell	facs-Lung-EPCAM-24m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A10 KCNK1 TMPRSS2 MUC4	1.84e-04	188	67	4	c2ef270f691d367b1621d48f0771267cefe1630d
ToppCell	facs-Trachea-3m-Epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRSS8 KCNK1 TMPRSS2 MUC4	1.88e-04	189	67	4	f8959cc2c14899c8dfeb1b5e51e187537df2f03e
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AGL DENND2C KCNK1 EXO1	1.96e-04	191	67	4	0f9443da0f73d07456142fae08b2dc92a5b7b592
ToppCell	facs-Lung-EPCAM-3m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 SLC25A10 KCNK1 MUC4	1.96e-04	191	67	4	629007189034ee8451411428f1c6cc57daee2d91
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-basal_bladder_epithelial_cell_(Krt5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN1 SLC25A10 KCNK1 TMPRSS2	1.96e-04	191	67	4	49068e3b7d265d4767d7b3c79d455dbc2fd8c6cd
ToppCell	droplet-Fat-Scat-18m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 TMPRSS2 PROC	2.00e-04	192	67	4	4098b5170c9995718758a082d1b8bcb86d5a289e
ToppCell	droplet-Fat-Scat-18m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 TMPRSS2 PROC	2.00e-04	192	67	4	936028fe851e8dd2b906df0210acc574c017b499
ToppCell	droplet-Fat-Scat-18m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 TMPRSS2 PROC	2.00e-04	192	67	4	62e55ed0d46b2e7b07dc42399972a099576cbc5f
ToppCell	facs-Lung-24m-Epithelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRSS8 SLC25A10 TMPRSS2 MUC4	2.00e-04	192	67	4	ebfd8209a7353fbccb8ca7ade14b4f25822cebd2
ToppCell	droplet-Bladder-nan-3m-Epithelial-bladder_urothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMID1 DENND2C KCNK1 TMPRSS2	2.04e-04	193	67	4	ee91a796d0f6d4cee7a93a525689e716fdceeda5
ToppCell	facs-Trachea-nan-3m-Epithelial-mucus_secreting_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 DGKG TMPRSS2	2.04e-04	193	67	4	3038ed3e53d3367136fac5c9773cd5b7414f49d3
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OXCT1 KCNK1 KCNQ1 TMPRSS2	2.04e-04	193	67	4	241a60d1f0d5832638fb3e1e4b7afa7387ea3c75
ToppCell	facs-Lung-3m-Epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRSS8 SLC25A10 KCNK1 TMPRSS2	2.04e-04	193	67	4	db5e43e0b571737e7006365bdf0575340b8b900b
ToppCell	facs-Trachea-nan-3m-Epithelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 TMPRSS2 MUC4	2.08e-04	194	67	4	3701ca87c6dc9ccd7b4146e56371546174d26c36
ToppCell	facs-Trachea-nan-3m-Epithelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 KCNK1 TMPRSS2 MUC4	2.08e-04	194	67	4	65f9bf126be26114c2c3f4c46d48318986212a92
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PRSS8 KCTD16 TMPRSS2 WDR49	2.08e-04	194	67	4	b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCell	droplet-Bladder-nan-3m-Epithelial-luminal_bladder_epithelial_cell_(umbrella_cell)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS8 EMID1 KCNK1 TMPRSS2	2.12e-04	195	67	4	d6e2a5a15bea16de5f7ff09318c67d46ea923203
ToppCell	tumor_Lymph_Node_/_Brain\|World / Location, Cell class and cell subclass	PRSS8 ADAM15 KCNK1 MUC4	2.16e-04	196	67	4	b39f938cbef54f08c53035738b97c76e7295733a
ToppCell	NS-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PRSS8 DENND2C TMPRSS2 MUC4	2.16e-04	196	67	4	453c809494ceffa2a28af283c4b5a4924fcf160f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 CD163L1 MAP3K20 F10	2.16e-04	196	67	4	5146976881d79642ebe5dcbcf89e0252713a9ef2
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A1 CD163L1 MAP3K20 F10	2.16e-04	196	67	4	ebac1d6af7a5732707d82d01285c086b19d8ae62
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRSS8 PRSS16 MUC4 PROC	2.20e-04	197	67	4	a137412f29a06e29efe8a5dd641839ff2aeeda0c
ToppCell	saliva\|World / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS8 KCNK1 TMPRSS2 MUC4	2.20e-04	197	67	4	0a7457dbf798f6071ada3b2b2be231ad13bdb660
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KLHL21 DENND2C KCNK1 MUC4	2.20e-04	197	67	4	233b9fcb376e08d0080a05ca0198ecc6ec720f90
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FFAR3 EMP3 SLC7A7 LFNG	2.20e-04	197	67	4	b4f6501c266328439cba4f174e594a6a04a252a1
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRSS8 PRSS16 MUC4 PROC	2.20e-04	197	67	4	c14dac1c8ba9d366d9dbefedb69f7b29d6fe6f4d
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FFAR3 EMP3 SLC7A7 LFNG	2.20e-04	197	67	4	c6e977adb1248957d31300312310e08238b64236
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KLHL21 DENND2C KCNK1 MUC4	2.25e-04	198	67	4	77517df37dc894c78ef1e2b24dd7ba31f928bdb7
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS8 KCNK1 TMPRSS2 MUC4	2.25e-04	198	67	4	fb3965049cb1961de0d2e74370868e46aa5050c8
ToppCell	NS-critical-d_07-13\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DENND2C KCNK1 TMPRSS2 MUC4	2.25e-04	198	67	4	a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS8 KCNK1 TMPRSS2 MUC4	2.25e-04	198	67	4	72d91bd0c727ecadc41e023a16c9326158db1b7b
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_interstitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MTMR14 ACSM5 PNPLA3 SLC7A7	2.25e-04	198	67	4	9a77038e5db0ea757fd7ebcab294785b166ddc12
ToppCell	Biopsy_Control_(H.)-Epithelial-SCGB3A2+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	PRSS8 TMPRSS2 TRPV6 MUC4	2.25e-04	198	67	4	1fe51f4beca0eef4ff117e6edaa646e35c0f9629
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS8 KCNK1 TMPRSS2 MUC4	2.25e-04	198	67	4	270cecff42b87b7e03f09dd9f99547b287b4598c
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS8 KCNK1 TMPRSS2 MUC4	2.25e-04	198	67	4	441608034c787e55691558a480dcd07e37419138
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS8 KCNK1 TMPRSS2 MUC4	2.25e-04	198	67	4	9f5726aedd1fb132feab717a029fa302306461b5
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS8 KCNK1 TMPRSS2 MUC4	2.25e-04	198	67	4	8b3f4effaaccf8777cde854d5d8a765962f7312b
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS8 KCNK1 TMPRSS2 MUC4	2.29e-04	199	67	4	5a1557fe35aa48080d4967e8724bf27f9585a5fb
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS8 KCNK1 TMPRSS2 MUC4	2.29e-04	199	67	4	0a657475b92aa3a713da62da364525249fdc3886
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FFAR3 EMP3 SLC7A7 LFNG	2.29e-04	199	67	4	e12cea071e46436835cc22fe7badcbe878a1305b
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FFAR3 EMP3 SLC7A7 LFNG	2.29e-04	199	67	4	2ff5007b971c6fca9a9ef433e257739f0322a2a5
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS8 KCNK1 TMPRSS2 MUC4	2.29e-04	199	67	4	a8f4bd0e65f36b29535864fae4347369d5c864d2
ToppCell	NS-critical-LOC-Epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PRSS8 KCNK1 TMPRSS2 MUC4	2.29e-04	199	67	4	d64adb68502be596ce55fb2cb63fe1cfa2c5f8ba
ToppCell	saliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-squamous_epithelial_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRSS8 KCNK1 TMPRSS2 MUC4	2.29e-04	199	67	4	eacea42e973f073b410f54c0a1b3a7f2dc2b5a29
ToppCell	distal-Epithelial\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PRSS8 KCNK1 TMPRSS2 MUC4	2.33e-04	200	67	4	0a97080f694738bb882787cee21b91a4d5757b7a
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	B9D2 PRSS8 NLE1 DNMBP	2.33e-04	200	67	4	68b0f987c4fb8078675475f4f1e71302f832ef69
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	B9D2 PRSS8 NLE1 DNMBP	2.33e-04	200	67	4	1b527bebbca1ef8c52449e40beb9358e37494e04
ToppCell	Biopsy_Other_PF-Epithelial\|Biopsy_Other_PF / Sample group, Lineage and Cell type	PRSS8 KCNK1 TMPRSS2 MUC4	2.33e-04	200	67	4	1ef4d5ae698fa721e0f510bf0d918bd8d3b00591
ToppCell	distal-2-Epithelial\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PRSS8 KCNK1 TMPRSS2 MUC4	2.33e-04	200	67	4	2fc1e95706f212bf18ecdf6eb5b3182ac98c9b52
ToppCell	medial-2-Epithelial\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PRSS8 KCNK1 TMPRSS2 MUC4	2.33e-04	200	67	4	0079041c3e654c1ef77c492bdb2f31ce8f4b507b
ToppCell	medial-Epithelial\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PRSS8 KCNK1 TMPRSS2 MUC4	2.33e-04	200	67	4	17bb9a9016058cbb70c7bd894c12f6208ff07895
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Nefm_(dSPN)-\|Striatum / BrainAtlas - Mouse McCarroll V32	FFAR3 TRPV6 DGAT2L6	2.39e-04	80	67	3	cb60461818f0900964d2a14c7f8462e7f37b3dff
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Nefm_(dSPN)\|Striatum / BrainAtlas - Mouse McCarroll V32	FFAR3 TRPV6 DGAT2L6	2.39e-04	80	67	3	27cc5ea77983fb0604545a0ff818eede8ba72b82
Computational	Serine proteases.	PRSS8 TMPRSS2 F10 PROC	1.23e-05	39	40	4	MODULE_109
Computational	Genes in the cancer module 107.	PRSS8 TMPRSS2 F10 PROC	2.02e-04	79	40	4	MODULE_107
Computational	Catabolic peptidases.	PRSS8 TMPRSS2 F10 PROC	3.20e-04	89	40	4	MODULE_209
Computational	Genes in the cancer module 172.	PRSS8 TMPRSS2 F10 PROC	4.27e-04	96	40	4	MODULE_172
Disease	bowel opening frequency	FFAR3 GPR42 LFNG	3.61e-05	30	63	3	EFO_0600084
Disease	Thrombus	VKORC1 F10 PROC	1.32e-04	46	63	3	C0087086
Disease	Thrombosis	VKORC1 F10 PROC	1.59e-04	49	63	3	C0040053
Disease	Dyskeratosis congenita	DKC1 WRAP53	1.60e-04	9	63	2	cv:C0265965
Disease	mitochondrial complex I deficiency (implicated_via_orthology)	SLC25A10 NDUFV1	2.00e-04	10	63	2	DOID:0060536 (implicated_via_orthology)
Disease	Blood Coagulation Disorders	VKORC1 F10	5.28e-04	16	63	2	C0005779
Disease	Dyskeratosis Congenita	DKC1 WRAP53	5.28e-04	16	63	2	C0265965
Disease	Congenital Fiber Type Disproportion	MTMR14 MAP3K20	6.71e-04	18	63	2	C0546264
Disease	diacylglycerol 38:5 measurement	DOK7 PNPLA3	7.49e-04	19	63	2	EFO_0020067
Disease	diacylglycerol 38:3 measurement	DOK7 PNPLA3	7.49e-04	19	63	2	EFO_0020065
Disease	epilepsy (biomarker_via_orthology)	SLC6A1 CAPN1	9.18e-04	21	63	2	DOID:1826 (biomarker_via_orthology)
Disease	prostate cancer, disease progression measurement	RFNG F10	1.20e-03	24	63	2	EFO_0008336, MONDO_0008315
Disease	taurine measurement	KCNK1 MUC4	1.41e-03	26	63	2	EFO_0010536
Disease	L lactate dehydrogenase measurement	CD163L1 KCNQ1	1.41e-03	26	63	2	EFO_0004808

Protein segments in the cluster

Peptide	Gene	Start	Entry
GRVRGYAGSWVSICT	ADAM15	121	Q13444
SYGLGFVASGRRWVA	ACSM5	246	Q6NUN0
GRSCWGARGFFPSSC	DNMBP	106	Q6XZF7
YSWAFGEGASARPRC	CFC1B	76	P0CG36
RCSGRLEVYFQGRWG	CD163L1	591	Q9NR16
SCAGRLEVFYNGTWG	CD163L1	1151	Q9NR16
YEGTWRRGSTAGGCR	CAPN1	371	P07384
RVSRWYFGGLASCGA	SLC25A10	6	Q9UBX3
GCGASSGALRSYQLW	DENND1C	411	Q8IV53
KFWFATGGAGFCLSR	RFNG	196	Q9Y644
GTFVVLRFWGCSGAR	MUC4	5386	Q99102
LRFWGCSGARFSYFL	MUC4	5391	Q99102
FFGTEYVVRLWSAGC	KCNQ1	166	P51787
WFATGGAGFCISRGL	LFNG	251	Q8NES3
RKWGFITVGYRGSCT	KCTD16	161	Q68DU8
ICRSATLAGWGELYG	MTMR14	141	Q8NCE2
RHRSAWCFGFLVLGY	KCNK1	16	O00180
VLGRWGNYSSGDCFI	PCNX2	1406	A6NKB5
RGWSLSFAGCGFLGF	PNPLA3	6	Q9NST1
SGSACRSLYGGFVEW	MVD	156	P53602
YGAFVSWGTCIRLAA	OR6Q1	136	Q8NGQ2
SYCYSRLVWILGRGG	GPR42	201	O15529
FYSFACGGWLRRHAI	ECEL1	126	O95672
DYCIQTLDGRWFGGR	HTATSF1	326	O43719
GSFSCDCRSGWEGRF	PROC	116	P04070
TGNDLARCLRWGGGY	DGKG	521	P49619
CGAVLAGRWNYEGTA	IFT80	106	Q9P2H3
GGSDGSRLYDCVWRY	KLHL21	341	Q9UJP4
FCTFHGRGFTRGSWG	DGAT2L6	261	Q6ZPD8
SYCYSRLVWILGRGG	FFAR3	201	O14843
GASWARAGAPRCTYT	ANGPTL6	16	Q8NI99
SGAWVCSQFPGYRGF	CRYBA4	146	P53673
FVLTGEDGSRWFGYC	DENND2C	561	Q68D51
NCGGGSFGSVYRAKW	MAP3K20	21	Q9NYL2
RGGSFGYCFALAWVA	EMP3	131	P54852
GAAPFSGRRNWCSYV	EMID1	26	Q96A84
GGTRCGYWAGVFFLS	DOK7	171	Q18PE1
YFVTGIVSWGEGCAR	F10	431	P00742
LWRLSGRFCGYAGFG	ZMPSTE24	101	O75844
WSQDSFGRCQLAGYG	B9D2	81	Q9BPU9
RRLGIFWVSCEAGTY	DKC1	211	O60832
CLRWGGDGLLYSASQ	NLE1	251	Q9NVX2
GQSWYFLGRCYSSIG	UTY	281	O14607
SCVGYAIGLGNVWRF	SLC6A1	56	P30531
ACGSYGRSLGLYAWD	WRAP53	341	Q9BUR4
FDGRSYSFWGGQGCR	SSPOP	576	A2VEC9
FFVTGDRAGGRSWCL	RNF8	6	O76064
SPTICRRGGTWFAGF	NDUFV1	251	P49821
CYLVTIFTGSRWGSG	PKDREJ	1231	Q9NTG1
LRLCASARGSGATWY	OXCT1	11	P55809
YLTGIVSWGDACGAR	PRSS8	251	Q16651
RSCFSWSGGLGDFSR	EXO1	606	Q9UQ84
THYLAEGWLFGRIGC	BRS3	106	P32247
SALWRYGLAVGCGAI	TMEM223	91	A0PJW6
YRCGVCGRGFLRSWY	ZNF865	876	P0CJ78
IGDTSWGSGCAKAYR	TMPRSS2	456	O15393
CSRVFSSRWGRGFGL	VKORC1	51	Q9BQB6
GGFRSSWCEDVRYLG	SPNS3	241	Q6ZMD2
YTLRCWAQGRGLSGS	TUT1	411	Q9H6E5
WAVGGLFSVFGALCY	SLC7A7	76	Q9UM01
NLVSCGGSGYVRFWD	WDR49	391	Q8IV35
SGICGREYGLGDRWF	TRPV6	656	Q9H1D0
GVSYGYWGCAIGKAR	PSMA3	156	P25788
LGLCFWAAGTAAARG	UNC5D	21	Q6UXZ4
VSGARFWGFFRNLCG	SMUG1	136	Q53HV7
SSLGDKGWGCGYRNF	ZUP1	351	Q96AP4
GSLYAWCGVGVISFA	TMEM242	86	Q9NWH2
CFGGSYAGSLAAWAR	PRSS16	181	Q9NQE7
FSSGIFRCWGRDTFI	AGL	1091	P35573