Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	TRAF3IP2 RFPL4A RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	4.79e-05	372	52	7	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRAF3IP2 RFPL4A RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	7.32e-05	398	52	7	GO:0061659
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	TRAF3IP2 RFPL4A RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	2.13e-04	473	52	7	GO:0004842
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	TRAF3IP2 RFPL4A RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	3.45e-04	512	52	7	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	TRAF3IP2 RFPL4A RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	4.34e-04	532	52	7	GO:0016755
GeneOntologyMolecularFunction	protein homodimerization activity	UBA5 RFPL4A TRNT1 RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	1.14e-03	815	52	8	GO:0042803
GeneOntologyMolecularFunction	nuclear retinoid X receptor binding	NCOR1 NCOR2	1.62e-03	23	52	2	GO:0046965
GeneOntologyMolecularFunction	5'-3' RNA polymerase activity	TRNT1 POLR2A	3.14e-03	32	52	2	GO:0034062
GeneOntologyMolecularFunction	RNA polymerase activity	TRNT1 POLR2A	3.14e-03	32	52	2	GO:0097747
GeneOntologyMolecularFunction	enzyme regulator activity	DOCK2 NCOR1 RAPGEF6 TBC1D4 PIK3CA TBC1D2 GPRC5D PPP1R36 FGD6 ITIH3	3.21e-03	1418	52	10	GO:0030234
GeneOntologyMolecularFunction	acyltransferase activity	TRAF3IP2 RFPL4A RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	3.78e-03	775	52	7	GO:0016746
GeneOntologyBiologicalProcess	regulation of viral entry into host cell	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	2.64e-07	55	52	5	GO:0046596
GeneOntologyBiologicalProcess	modulation by symbiont of entry into host	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	4.85e-07	62	52	5	GO:0052372
GeneOntologyBiologicalProcess	regulation of biological process involved in symbiotic interaction	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	1.26e-06	75	52	5	GO:0043903
GeneOntologyBiologicalProcess	positive regulation of NF-kappaB transcription factor activity	RFPL4A RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	2.15e-06	151	52	6	GO:0051092
GeneOntologyBiologicalProcess	process utilizing autophagic mechanism	UBA5 RFPL4A PIK3CA DAPK2 VPS33A UBQLN4 RFPL1 RFPL3 RFPL2 RFPL4AL1	4.32e-06	650	52	10	GO:0061919
GeneOntologyBiologicalProcess	autophagy	UBA5 RFPL4A PIK3CA DAPK2 VPS33A UBQLN4 RFPL1 RFPL3 RFPL2 RFPL4AL1	4.32e-06	650	52	10	GO:0006914
GeneOntologyBiologicalProcess	regulation of autophagy	RFPL4A PIK3CA DAPK2 UBQLN4 RFPL1 RFPL3 RFPL2 RFPL4AL1	6.66e-06	400	52	8	GO:0010506
GeneOntologyBiologicalProcess	positive regulation of canonical NF-kappaB signal transduction	TRAF3IP2 RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	1.55e-05	213	52	6	GO:0043123
GeneOntologyBiologicalProcess	regulation of viral life cycle	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	4.53e-05	156	52	5	GO:1903900
GeneOntologyBiologicalProcess	positive regulation of DNA-binding transcription factor activity	RFPL4A RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	4.84e-05	261	52	6	GO:0051091
GeneOntologyBiologicalProcess	symbiont entry into host cell	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	6.63e-05	169	52	5	GO:0046718
GeneOntologyBiologicalProcess	positive regulation of autophagy	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	7.40e-05	173	52	5	GO:0010508
GeneOntologyBiologicalProcess	symbiont entry into host	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	8.03e-05	176	52	5	GO:0044409
GeneOntologyBiologicalProcess	protein polyubiquitination	TRAF3IP2 RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	8.51e-05	289	52	6	GO:0000209
GeneOntologyBiologicalProcess	regulation of canonical NF-kappaB signal transduction	TRAF3IP2 RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	1.01e-04	298	52	6	GO:0043122
GeneOntologyBiologicalProcess	regulation of viral process	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	1.04e-04	186	52	5	GO:0050792
GeneOntologyBiologicalProcess	regulation of DNA-binding transcription factor activity	FZD6 RFPL4A RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	1.27e-04	449	52	7	GO:0051090
GeneOntologyBiologicalProcess	canonical NF-kappaB signal transduction	TRAF3IP2 RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	1.76e-04	330	52	6	GO:0007249
GeneOntologyBiologicalProcess	viral life cycle	RFPL4A CXCR6 RFPL1 RFPL3 RFPL2 RFPL4AL1	2.06e-04	340	52	6	GO:0019058
GeneOntologyBiologicalProcess	biological process involved in interaction with host	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	2.69e-04	228	52	5	GO:0051701
GeneOntologyBiologicalProcess	skin development	FZD6 TRAF3IP2 NCOR1 NCOR2 NOM1 GPRC5D	3.39e-04	373	52	6	GO:0043588
GeneOntologyBiologicalProcess	establishment of T cell polarity	DOCK2 TRAF3IP2	6.41e-04	15	52	2	GO:0001768
GeneOntologyBiologicalProcess	establishment of lymphocyte polarity	DOCK2 TRAF3IP2	7.31e-04	16	52	2	GO:0001767
GeneOntologyBiologicalProcess	positive regulation of molecular function	RFPL4A RAPGEF6 TBC1D4 PIK3CA TBC1D2 RFPL1 ADCY3 TRIM37 RFPL3 RFPL2 RFPL4AL1	7.36e-04	1430	52	11	GO:0044093
GeneOntologyBiologicalProcess	skin epidermis development	FZD6 NCOR1 NCOR2 NOM1	8.11e-04	166	52	4	GO:0098773
GeneOntologyBiologicalProcess	quinone biosynthetic process	COQ8A RTN4IP1	8.28e-04	17	52	2	GO:1901663
GeneOntologyBiologicalProcess	negative regulation of androgen receptor signaling pathway	NCOR1 NCOR2	8.28e-04	17	52	2	GO:0060766
GeneOntologyBiologicalProcess	ubiquinone biosynthetic process	COQ8A RTN4IP1	8.28e-04	17	52	2	GO:0006744
GeneOntologyBiologicalProcess	regulation of catabolic process	TRAF3IP2 NCOR1 RFPL4A PIK3CA DAPK2 UBQLN4 RFPL1 RFPL3 RFPL2 RFPL4AL1	9.99e-04	1252	52	10	GO:0009894
GeneOntologyBiologicalProcess	cellular catabolic process	UBA5 RFPL4A PIK3CA DAPK2 VPS33A UBQLN4 RFPL1 RFPL3 RFPL2 RFPL4AL1	1.01e-03	1253	52	10	GO:0044248
GeneOntologyBiologicalProcess	viral process	RFPL4A CXCR6 RFPL1 RFPL3 RFPL2 RFPL4AL1	1.06e-03	464	52	6	GO:0016032
GeneOntologyBiologicalProcess	ubiquinone metabolic process	COQ8A RTN4IP1	1.15e-03	20	52	2	GO:0006743
GeneOntologyCellularComponent	female germ cell nucleus	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	1.26e-08	31	52	5	GO:0001674
GeneOntologyCellularComponent	germ cell nucleus	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	8.96e-06	113	52	5	GO:0043073
Domain	RDM	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	1.37e-13	5	52	5	PF11002
Domain	RDM_domain_RFPL	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	1.37e-13	5	52	5	IPR022723
Domain	PRY	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	1.08e-07	42	52	5	PF13765
Domain	PRY	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	2.15e-07	48	52	5	SM00589
Domain	PRY	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	2.15e-07	48	52	5	IPR006574
Domain	Butyrophylin	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	1.45e-06	70	52	5	IPR003879
Domain	SPRY	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	4.27e-06	87	52	5	SM00449
Domain	SPRY	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	6.25e-06	94	52	5	PF00622
Domain	SPRY_dom	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	6.25e-06	94	52	5	IPR003877
Domain	B30.2/SPRY	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	6.59e-06	95	52	5	IPR001870
Domain	B302_SPRY	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	6.59e-06	95	52	5	PS50188
Domain	N-CoR_GPS2_interact	NCOR1 NCOR2	7.60e-06	2	52	2	IPR031557
Domain	GPS2_interact	NCOR1 NCOR2	7.60e-06	2	52	2	PF15784
Domain	ZF_RING_2	RFPL4A RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	1.72e-04	298	52	6	PS50089
Domain	-	RFPL4A RFPL1 FGD6 TRIM37 RFPL3 RFPL2 RFPL4AL1	2.33e-04	449	52	7	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RFPL4A RFPL1 FGD6 TRIM37 RFPL3 RFPL2 RFPL4AL1	2.66e-04	459	52	7	IPR013083
Domain	Znf_RING	RFPL4A RFPL1 TRIM37 RFPL3 RFPL2 RFPL4AL1	2.80e-04	326	52	6	IPR001841
Domain	ARM-type_fold	DOCK2 DNAJC13 PIK3CA NOM1 EIF3K FMNL2	3.45e-04	339	52	6	IPR016024
Domain	ConA-like_dom	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	3.52e-04	219	52	5	IPR013320
Domain	ZF_RING_1	RFPL4A RFPL1 TRIM37 RFPL3 RFPL2	1.27e-03	291	52	5	PS00518
Domain	RING	RFPL4A RFPL1 TRIM37 RFPL3 RFPL2	1.56e-03	305	52	5	SM00184
Domain	SANT_dom	NCOR1 NCOR2	2.37e-03	26	52	2	IPR017884
Domain	SANT	NCOR1 NCOR2	2.74e-03	28	52	2	PS51293
Domain	Myb_DNA-binding	NCOR1 NCOR2	4.27e-03	35	52	2	PF00249
Domain	UBIQUITIN_1	SACS UBQLN4	4.76e-03	37	52	2	PS00299
Domain	MYB_LIKE	NCOR1 NCOR2	5.01e-03	38	52	2	PS50090
Domain	ubiquitin	SACS UBQLN4	7.59e-03	47	52	2	PF00240
Domain	DNAJ_1	DNAJC13 SACS	8.22e-03	49	52	2	PS00636
Domain	DNAJ_2	DNAJC13 SACS	8.22e-03	49	52	2	PS50076
Domain	TBC	TBC1D4 TBC1D2	8.22e-03	49	52	2	SM00164
Domain	DnaJ	DNAJC13 SACS	8.22e-03	49	52	2	SM00271
Domain	-	DNAJC13 SACS	8.22e-03	49	52	2	1.10.287.110
Domain	SANT	NCOR1 NCOR2	8.55e-03	50	52	2	SM00717
Domain	DnaJ_domain	DNAJC13 SACS	8.88e-03	51	52	2	IPR001623
Domain	SANT/Myb	NCOR1 NCOR2	9.22e-03	52	52	2	IPR001005
Pubmed	The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	6.13e-15	5	52	5	11850190
Pubmed	RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	3.42e-13	8	52	5	12525704
Pubmed	ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles.	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	1.01e-09	31	52	5	31657143
Pubmed	NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	2.58e-09	37	52	5	15326356
Pubmed	Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development.	RFPL1 RFPL3 RFPL2	3.15e-09	3	52	3	18656177
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	NCOR1 NCOR2 DNAJC13 PPAN RAPGEF6 UTP18 TBC1D4 POLR2A TBC1D2 MED14 INTS3	1.63e-08	774	52	11	15302935
Pubmed	Duplications on human chromosome 22 reveal a novel Ret Finger Protein-like gene family with sense and endogenous antisense transcripts.	RFPL1 RFPL3 RFPL2	3.15e-08	5	52	3	10508838
Pubmed	Epigenetic control of a VDR-governed feed-forward loop that regulates p21(waf1/cip1) expression and function in non-malignant prostate cells.	NCOR1 NCOR2 POLR2A	3.15e-08	5	52	3	21088000
Pubmed	Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection.	SLC32A1 NCOR1 NCOR2	3.15e-08	5	52	3	30664766
Pubmed	NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.	NCOR1 NCOR2	2.19e-06	2	52	2	29531310
Pubmed	CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.	NCOR1 NCOR2	2.19e-06	2	52	2	27733359
Pubmed	Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes.	NCOR1 NCOR2	2.19e-06	2	52	2	22944139
Pubmed	Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants.	NCOR1 NCOR2	2.19e-06	2	52	2	21131350
Pubmed	Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling.	NCOR1 NCOR2	2.19e-06	2	52	2	26166430
Pubmed	Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways.	NCOR1 NCOR2	2.19e-06	2	52	2	19299558
Pubmed	Unique forms of human and mouse nuclear receptor corepressor SMRT.	NCOR1 NCOR2	2.19e-06	2	52	2	10077563
Pubmed	Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism via Intestinal Regulation of Carbohydrate Transport.	NCOR1 NCOR2	2.19e-06	2	52	2	39106294
Pubmed	Evolution of NCoR-1 and NCoR-2 corepressor alternative mRNA splicing in placental mammals.	NCOR1 NCOR2	2.19e-06	2	52	2	31208445
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	DOCK2 UBA5 NCOR2 METTL13 DNAJC13 VPS33A INTS3 HNRNPLL	2.31e-06	582	52	8	20467437
Pubmed	Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus.	NCOR1 NCOR2	6.57e-06	3	52	2	16030140
Pubmed	Involvement of SMRT corepressor in transcriptional repression by the vitamin D receptor.	NCOR1 NCOR2	6.57e-06	3	52	2	19098224
Pubmed	The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.	NCOR1 NCOR2	6.57e-06	3	52	2	16373395
Pubmed	Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action.	NCOR1 NCOR2	6.57e-06	3	52	2	31404087
Pubmed	Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.	NCOR1 NCOR2	6.57e-06	3	52	2	22337871
Pubmed	Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.	NCOR1 NCOR2	6.57e-06	3	52	2	23292142
Pubmed	Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors.	NCOR1 NCOR2	6.57e-06	3	52	2	15016838
Pubmed	Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.	NCOR1 NCOR2	6.57e-06	3	52	2	24268577
Pubmed	Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis.	NCOR1 NCOR2	6.57e-06	3	52	2	34390859
Pubmed	Oligomerization of ETO is obligatory for corepressor interaction.	NCOR1 NCOR2	6.57e-06	3	52	2	11113190
Pubmed	RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding.	NCOR1 NCOR2	6.57e-06	3	52	2	12011091
Pubmed	EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.	NCOR1 NCOR2	6.57e-06	3	52	2	21518914
Pubmed	Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.	NCOR1 NCOR2	6.57e-06	3	52	2	15802375
Pubmed	KCNQ2 channels regulate the population activity of neonatal GABAergic neurons ex vivo.	SLC32A1 POLR2A	6.57e-06	3	52	2	37409016
Pubmed	SMRT and NCoR1 fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling.	NCOR1 NCOR2	6.57e-06	3	52	2	36238311
Pubmed	The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD.	NCOR1 NCOR2	6.57e-06	3	52	2	10406466
Pubmed	Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.	NCOR1 NCOR2	6.57e-06	3	52	2	36316474
Pubmed	The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha.	NCOR1 NCOR2	6.57e-06	3	52	2	18052923
Pubmed	The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.	NCOR1 NCOR2	6.57e-06	3	52	2	11997503
Pubmed	Structural basis for nuclear receptor corepressor recruitment by antagonist-liganded androgen receptor.	NCOR1 NCOR2	6.57e-06	3	52	2	18852122
Pubmed	MicroRNAs are mediators of androgen action in prostate and muscle.	NCOR1 NCOR2	1.31e-05	4	52	2	21048966
Pubmed	Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.	NCOR1 NCOR2	1.31e-05	4	52	2	9819405
Pubmed	Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimers.	NCOR1 NCOR2	1.31e-05	4	52	2	18362166
Pubmed	Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex.	NCOR1 NCOR2	1.31e-05	4	52	2	18632669
Pubmed	Dichotomous engagement of HDAC3 activity governs inflammatory responses.	NCOR1 NCOR2	1.31e-05	4	52	2	32760002
Pubmed	A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones.	NCOR1 NCOR2	1.31e-05	4	52	2	19147680
Pubmed	A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain.	NCOR1 NCOR2	1.31e-05	4	52	2	32072640
Pubmed	NCoR1 and SMRT play unique roles in thyroid hormone action in vivo.	NCOR1 NCOR2	1.31e-05	4	52	2	25421714
Pubmed	Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK.	NCOR1 NCOR2	1.31e-05	4	52	2	15878880
Pubmed	FBI-1 functions as a novel AR co-repressor in prostate cancer cells.	NCOR1 NCOR2	1.31e-05	4	52	2	20812024
Pubmed	Direct association between the CREB-binding protein (CBP) and nuclear receptor corepressor (N-CoR).	NCOR1 NCOR2	1.31e-05	4	52	2	17073437
Pubmed	The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.	NCOR1 NCOR2	1.31e-05	4	52	2	16024608
Pubmed	Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.	METTL13 PIK3CA	1.31e-05	4	52	2	12186904
Pubmed	The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3.	NCOR1 NCOR2	1.31e-05	4	52	2	11509652
Pubmed	The retinoid X receptor binding to the thyroid hormone receptor: relationship with cofactor binding and transcriptional activity.	NCOR1 NCOR2	1.31e-05	4	52	2	19211732
Pubmed	Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint.	NCOR1 NCOR2	1.31e-05	4	52	2	19595715
Pubmed	Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.	NCOR1 NCOR2	1.31e-05	4	52	2	16121196
Pubmed	A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation.	NCOR1 NCOR2	1.31e-05	4	52	2	12840002
Pubmed	Nuclear receptor coregulator SNP discovery and impact on breast cancer risk.	NCOR1 NCOR2	1.31e-05	4	52	2	20003447
Pubmed	A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.	NCOR1 NCOR2	1.31e-05	4	52	2	20543827
Pubmed	GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression.	NCOR1 NCOR2	1.31e-05	4	52	2	26712002
Pubmed	Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex.	NCOR1 NCOR2	1.31e-05	4	52	2	26712006
Pubmed	Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.	NCOR1 NCOR2	2.19e-05	5	52	2	7566114
Pubmed	ERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus.	NCOR1 NCOR2	2.19e-05	5	52	2	12904255
Pubmed	Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.	NCOR1 NCOR2	2.19e-05	5	52	2	15175761
Pubmed	Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor.	NCOR1 NCOR2	2.19e-05	5	52	2	14593076
Pubmed	Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.	NCOR1 NCOR2	2.19e-05	5	52	2	11865059
Pubmed	Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells.	NCOR1 NCOR2	2.19e-05	5	52	2	23703729
Pubmed	Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.	NCOR1 NCOR2	2.19e-05	5	52	2	15531890
Pubmed	Binding of liganded vitamin D receptor to the vitamin D receptor interacting protein coactivator complex induces interaction with RNA polymerase II holoenzyme.	POLR2A MED14	2.19e-05	5	52	2	10753860
Pubmed	Combinatorial roles of the nuclear receptor corepressor in transcription and development.	NCOR1 NCOR2	2.19e-05	5	52	2	11030619
Pubmed	Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction.	NCOR1 NCOR2	2.19e-05	5	52	2	29033129
Pubmed	The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures.	NCOR1 NCOR2	2.19e-05	5	52	2	16033423
Pubmed	Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex.	NCOR1 NCOR2	2.19e-05	5	52	2	16712523
Pubmed	The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3.	NCOR1 NCOR2	2.19e-05	5	52	2	15832170
Pubmed	Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells.	NCOR1 NCOR2	2.19e-05	5	52	2	15729358
Pubmed	Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas.	NCOR1 NCOR2	2.19e-05	5	52	2	21143702
Pubmed	The histone deacetylase-3 complex contains nuclear receptor corepressors.	NCOR1 NCOR2	2.19e-05	5	52	2	10860984
Pubmed	A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.	NCOR1 NCOR2	2.19e-05	5	52	2	10809664
Pubmed	Mouse germline restriction of Oct4 expression by germ cell nuclear factor.	NCOR1 NCOR2	2.19e-05	5	52	2	11702949
Pubmed	Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status.	NCOR1 NCOR2	2.19e-05	5	52	2	10803578
Pubmed	Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300.	NCOR1 NCOR2	2.19e-05	5	52	2	14985122
Pubmed	Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.	NCOR1 NCOR2	3.28e-05	6	52	2	26859354
Pubmed	Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex.	NCOR1 NCOR2	3.28e-05	6	52	2	9405624
Pubmed	SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR.	NCOR1 NCOR2	3.28e-05	6	52	2	19955185
Pubmed	Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines.	NCOR1 NCOR2	3.28e-05	6	52	2	18832723
Pubmed	MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer.	NCOR1 NCOR2	3.28e-05	6	52	2	20388878
Pubmed	Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis.	NCOR1 NCOR2	3.28e-05	6	52	2	27506116
Pubmed	The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators.	NCOR1 NCOR2	3.28e-05	6	52	2	9878542
Pubmed	AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor.	NCOR1 NCOR2	3.28e-05	6	52	2	12460926
Pubmed	Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.	NCOR1 NCOR2	3.28e-05	6	52	2	10640275
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	NCOR1 NCOR2 DNAJC13 RAPGEF6 TBC1D4 UBQLN4	3.71e-05	418	52	6	34709266
Pubmed	MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.	NCOR1 NCOR2	4.58e-05	7	52	2	15454082
Pubmed	The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling.	NCOR1 NCOR2	4.58e-05	7	52	2	11867749
Pubmed	A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity.	NCOR1 NCOR2	4.58e-05	7	52	2	16980585
Pubmed	SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.	NCOR1 NCOR2	4.58e-05	7	52	2	18500350
Pubmed	Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.	NCOR1 NCOR2	4.58e-05	7	52	2	11804585
Pubmed	Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.	NCOR1 NCOR2	4.58e-05	7	52	2	29523594
Pubmed	Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.	NCOR1 NCOR2	4.58e-05	7	52	2	11903058
Pubmed	The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.	NCOR1 NCOR2	4.58e-05	7	52	2	15695367
Pubmed	Maternal microRNAs are essential for mouse zygotic development.	RFPL4A RFPL1 RFPL3 RFPL2 RFPL4AL1	5.52e-05	273	52	5	17369397
Interaction	SNW1 interactions	DOCK2 UBA5 ZMAT3 NCOR1 NCOR2 METTL13 DNAJC13 DHX35 INTS3 HNRNPLL TRIM37	2.07e-06	747	51	11	int:SNW1
Interaction	RFPL3 interactions	RFPL1 RFPL3 RFPL2	1.69e-05	20	51	3	int:RFPL3
Cytoband	17q23.2	OR4D1 TRIM37	6.50e-04	33	52	2	17q23.2
Cytoband	22q12.3	RFPL3 RFPL2	6.50e-04	33	52	2	22q12.3
Cytoband	3q22.1	UBA5 DNAJC13	1.05e-03	42	52	2	3q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr22q12	RFPL1 RFPL3 RFPL2	2.43e-03	235	52	3	chr22q12
Cytoband	Ensembl 112 genes in cytogenetic band chr17q22	OR4D1 TRIM37	4.53e-03	88	52	2	chr17q22
Cytoband	6q21	TRAF3IP2 RTN4IP1	5.36e-03	96	52	2	6q21
Cytoband	Ensembl 112 genes in cytogenetic band chr2p22	NDUFAF7 HNRNPLL	6.26e-03	104	52	2	chr2p22
Cytoband	Ensembl 112 genes in cytogenetic band chr6q21	TRAF3IP2 RTN4IP1	8.38e-03	121	52	2	chr6q21
Cytoband	19q13.42	RFPL4A RFPL4AL1	8.92e-03	125	52	2	19q13.42
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	NCOR1 SACS NOM1 PPP1R36	4.46e-04	181	36	4	694
GeneFamily	Ring finger proteins	RFPL4A RFPL1 TRIM37 RFPL2	2.10e-03	275	36	4	58
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC13 SACS	4.27e-03	49	36	2	584
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	NCOR1 NCOR2	4.98e-03	53	36	2	532
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBC1D4 CXCR6 DHX35 HNRNPLL ADCY3	1.99e-06	177	52	5	f4ddf0ef0eade13b9835a5684a8dbb6f71be4697
Drug	Tiletamine hydrochloride; Down 200; 15.4uM; PC3; HT_HG-U133A	WDR19 NCOR2 TBC1D4 VPS33A MED14 FGD6	6.02e-06	199	52	6	7311_DN
Disease	C-C motif chemokine 21 measurement	UBA5 DNAJC13	1.31e-04	10	51	2	EFO_0008048
Disease	atopic dermatitis (implicated_via_orthology)	TRAF3IP2 CTSE	1.59e-04	11	51	2	DOID:3310 (implicated_via_orthology)
Disease	Adenocarcinoma Of Esophagus	DOCK2 PIK3CA	2.63e-04	14	51	2	C0279628

Protein segments in the cluster

Peptide	Gene	Start	Entry
SMTMMPALFKENRND	CAGE1	761	Q8TC20
VMAVFLLTQMPFNLM	CXCR6	236	O00574
MMDKFRMIFQFLQSN	CALHM1	1	Q8IU99
MMGNLVMFRKDSVLN	INTS3	781	Q68E01
MMMPFKRQALVEFEN	HNRNPLL	106	Q8WVV9
RIKFINMNGLMADPM	NCOR2	406	Q9Y618
FDNMMAQNLVDLPMF	CTSE	201	P14091
TMNPRMRKFQVDMTF	RFPL4A	86	A6NLU0
QMKFLVEQMRRPDFM	PIK3CA	731	P42336
APMMVSNILKRFAEM	MED14	1411	O60244
RCMKMAYNMTFFPNL	FZD6	31	O60353
MQLMTQFPNAEKMNT	DOCK2	1376	Q92608
MMFVNMTPCQLNVDF	GPRC5D	156	Q9NZD1
MFQASMRSPNMEPFK	DAPK2	1	Q9UIK4
MRIAEFPLNPMFAKM	DHX35	481	Q9H5Z1
RQSADFMPLKQMMKT	COQ8A	301	Q8NI60
RNTFLLSMRFMDPEM	ADCY3	606	O60266
MAMFEQMRANVGKLL	EIF3K	1	Q9UBQ5
DRFMMQFSKIERLMQ	FMNL2	766	Q96PY5
LMKFLPSVFMDAMRD	DNAJC13	1896	O75165
NATRRPQMSFLKMDM	METTL13	91	Q8N6R0
IIMSREFMIMFDPNI	SACS	1571	Q9NZJ4
GVPSAMQDKFNFMML	CYP8B1	266	Q9UNU6
MLNPMIYTLRNQDMK	OR4D1	281	Q15615
YGKNEVLRFTQNMMM	RTN4IP1	51	Q8WWV3
MNNRFRKDMMKNASE	UTP18	156	Q9Y5J1
TMNPRMRKFQVDMTF	RFPL4AL1	86	F8VTS6
MNPRMRKFQVDMTLD	RFPL1	116	O75677
MMFQQVHRKPMASFV	TRIM37	246	O94972
PTQMKEMFQSAGIRM	TRNT1	86	Q96Q11
ANMDPAMMFRQRSLS	RAPGEF6	1056	Q8TEU7
MLMNPKKMGERFNFF	NDUFAF7	391	Q7L592
SMMINRKNMVVSFGD	ITIH3	756	Q06033
MMFDAEQRRVKFINM	NCOR1	406	O75376
RFMLETMLALKNNDM	NOM1	546	Q5C9Z4
PSNMQFFLMKMDDRT	WDR19	181	Q8NEZ3
RMMMGKPSQLQSQFR	SKIV2L	731	Q15477
MEMLFSMFPNQGEVK	RWDD2A	16	Q9UIY3
MMQIEFIKQGSMNFR	TRAF3IP2	501	O43734
MHVKLMATMFQNLFP	PPAN	151	Q9NQ55
NAMQDFFPTMSMKPN	UBA5	286	Q9GZZ9
VIFNRQPTLHKMSMM	POLR2A	456	P24928
RKVMQPRMFFLFNDA	FGD6	1101	Q6ZV73
MTFVQFRRMMAKRPA	PPP1R36	291	Q96LQ0
QMNPRMRKFQVDMTL	RFPL2	176	O75678
MNPRMRKFQVDMTLD	RFPL3	116	O75679
RKQYRPDMMSLQIQM	TBC1D4	1041	O60343
NEFKMMPNRRNMYTV	ZMAT3	201	Q9HA38
QAKMSGMFARMGFQA	SLC32A1	21	Q9H598
QVANMMIRMKREFTG	VPS33A	201	Q96AX1
AQIQNMTTSPMFMEK	TRAPPC13	196	A5PLN9
MRSMMQTLAQNPDFA	UBQLN4	406	Q9NRR5
KLMNIAFNDMNPFRM	TBC1D2	861	Q9BYX2