Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase I general transcription initiation factor activity

UBTFL6 UBTFL1

3.05e-049592GO:0001181
GeneOntologyMolecularFunctionRNA polymerase I core promoter sequence-specific DNA binding

UBTFL6 UBTFL1

4.64e-0411592GO:0001164
GeneOntologyMolecularFunctionsemaphorin receptor activity

PLXNA3 PLXNA1

5.56e-0412592GO:0017154
GeneOntologyMolecularFunctionRNA polymerase I transcription regulatory region sequence-specific DNA binding

UBTFL6 UBTFL1

6.56e-0413592GO:0001163
GeneOntologyBiologicalProcessolfactory nerve formation

PLXNA3 PLXNA1

7.77e-062582GO:0021628
GeneOntologyBiologicalProcessolfactory nerve morphogenesis

PLXNA3 PLXNA1

2.33e-053582GO:0021627
GeneOntologyBiologicalProcessgonadotrophin-releasing hormone neuronal migration to the hypothalamus

PLXNA3 PLXNA1

1.62e-047582GO:0021828
GeneOntologyBiologicalProcesshypothalamic tangential migration using cell-axon interactions

PLXNA3 PLXNA1

1.62e-047582GO:0021856
GeneOntologyBiologicalProcessolfactory nerve development

PLXNA3 PLXNA1

2.15e-048582GO:0021553
GeneOntologyBiologicalProcesshypothalamus cell migration

PLXNA3 PLXNA1

2.76e-049582GO:0021855
GeneOntologyBiologicalProcesshypothalamus gonadotrophin-releasing hormone neuron differentiation

PLXNA3 PLXNA1

2.76e-049582GO:0021886
GeneOntologyBiologicalProcesshypothalamus gonadotrophin-releasing hormone neuron development

PLXNA3 PLXNA1

2.76e-049582GO:0021888
Domain-

PLXNA3 WDR7 CFAP57 DCAF4 DCAF5 PLXNA1 BTRC

5.23e-053335572.130.10.10
DomainWD40/YVTN_repeat-like_dom

PLXNA3 WDR7 CFAP57 DCAF4 DCAF5 PLXNA1 BTRC

5.44e-05335557IPR015943
DomainPSI

PLXNA3 ATRN PLXNA1

1.13e-0432553PF01437
DomainPlexin_repeat

PLXNA3 ATRN PLXNA1

1.13e-0432553IPR002165
DomainPSI

PLXNA3 ATRN PLXNA1

2.94e-0444553IPR016201
DomainPlexin_cytopl

PLXNA3 PLXNA1

3.02e-049552PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA3 PLXNA1

3.02e-049552IPR013548
DomainPlexin

PLXNA3 PLXNA1

3.02e-049552IPR031148
DomainPSI

PLXNA3 ATRN PLXNA1

3.35e-0446553SM00423
DomainWD40

WDR7 CFAP57 DCAF4 DCAF5 BTRC

9.75e-04259555PF00400
DomainWD40

WDR7 CFAP57 DCAF4 DCAF5 BTRC

1.14e-03268555SM00320
DomainWD40_repeat

WDR7 CFAP57 DCAF4 DCAF5 BTRC

1.21e-03272555IPR001680
DomainWD_REPEATS_1

WDR7 CFAP57 DCAF4 DCAF5 BTRC

1.34e-03278555PS00678
DomainWD_REPEATS_2

WDR7 CFAP57 DCAF4 DCAF5 BTRC

1.36e-03279555PS50082
DomainWD_REPEATS_REGION

WDR7 CFAP57 DCAF4 DCAF5 BTRC

1.36e-03279555PS50294
DomainWD40_repeat_dom

WDR7 CFAP57 DCAF4 DCAF5 BTRC

1.79e-03297555IPR017986
DomainUbiquitin-rel_dom

FRMPD1 RASSF10 DDI2 RASSF4

2.10e-03184554IPR029071
DomainIPT

PLXNA3 PLXNA1

2.85e-0327552SM00429
DomainSpectrin_repeat

SPTBN2 EVPL

3.29e-0329552IPR002017
DomainTIG

PLXNA3 PLXNA1

3.75e-0331552PF01833
DomainRA

RASSF10 RASSF4

3.75e-0331552SM00314
DomainSema

PLXNA3 PLXNA1

3.75e-0331552SM00630
DomainSemap_dom

PLXNA3 PLXNA1

3.75e-0331552IPR001627
DomainSema

PLXNA3 PLXNA1

3.75e-0331552PF01403
DomainSEMA

PLXNA3 PLXNA1

3.75e-0331552PS51004
DomainSpectrin/alpha-actinin

SPTBN2 EVPL

3.99e-0332552IPR018159
DomainIPT

PLXNA3 PLXNA1

3.99e-0332552IPR002909
DomainSPEC

SPTBN2 EVPL

3.99e-0332552SM00150
DomainRA

RASSF10 RASSF4

5.31e-0337552PS50200
DomainWHTH_DNA-bd_dom

LARP6 IRF8 RAD21L1 MYSM1

5.59e-03242554IPR011991
DomainRA_dom

RASSF10 RASSF4

6.18e-0340552IPR000159
DomainHMG_box

UBTFL6 UBTFL1

1.07e-0253552PF00505
DomainQuinoprotein_ADH-like_supfam

WDR7 CFAP57

1.07e-0253552IPR011047
DomainHMG_BOX_2

UBTFL6 UBTFL1

1.10e-0254552PS50118
DomainHMG

UBTFL6 UBTFL1

1.10e-0254552SM00398
PathwayWP_DNA_IRDAMAGE_AND_CELLULAR_RESPONSE_VIA_ATR

PPM1D CLSPN CEP164 CDC45

4.62e-0581354M39490
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

PLXNA3 PLXNA1

2.13e-049352MM15030
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA3 PLXNA1

5.35e-0414352MM15029
PathwayREACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION

PLXNA3 PLXNA1

5.35e-0414352M7578
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

PLXNA3 PLXNA1

6.16e-0415352MM15031
PathwayREACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION

PLXNA3 PLXNA1

7.03e-0416352M16498
PathwayREACTOME_CRMPS_IN_SEMA3A_SIGNALING

PLXNA3 PLXNA1

7.03e-0416352M8245
PathwayBIOCARTA_CCR3_PATHWAY

PPP1R12B GNAS

9.97e-0419352MM1361
PathwayBIOCARTA_CCR3_PATHWAY

PPP1R12B GNAS

9.97e-0419352M9152
Pubmed

Identification of plexin family molecules in mice.

PLXNA3 PLXNA1

9.07e-0636128806646
Pubmed

GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival.

CLSPN BTRC

9.07e-06361231362447
Pubmed

Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage.

CLSPN CDC45

9.07e-06361223910567
Pubmed

Differential expression of plexin-A subfamily members in the mouse nervous system.

PLXNA3 PLXNA1

9.07e-06361211241833
Pubmed

Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner.

PLXNA3 PLXNA1

9.07e-06361220138877
Pubmed

CHD1 acts via the Hmgpi pathway to regulate mouse early embryogenesis.

UBTFL6 UBTFL1

9.07e-06361226092847
Pubmed

Mysm1 is required for interferon regulatory factor expression in maintaining HSC quiescence and thymocyte development.

IRF8 MYSM1

9.07e-06361227277682
Pubmed

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.

CLSPN BTRC

1.81e-05461216885022
Pubmed

Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress.

CLSPN BTRC

1.81e-05461216885021
Pubmed

Determination of cell adhesion sites of neuropilin-1.

PLXNA3 PLXNA1

1.81e-05461210725340
Pubmed

Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.

PLXNA3 PLXNA1

1.81e-05461211306810
Pubmed

Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis.

CLSPN BTRC

1.81e-05461219270156
Pubmed

PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.

PLXNA3 PLXNA1

1.81e-05461225518740
Pubmed

A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.

PLXNA3 PLXNA1

1.81e-0546128570614
Pubmed

Characterization of functional domains in human Claspin.

CLSPN CDC45

3.02e-05561221478680
Pubmed

Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.

PLXNA3 PLXNA1

3.02e-05561225313870
Pubmed

Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development.

UBTFL6 UBTFL1

4.52e-05661219915186
Pubmed

Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.

PLXNA3 PLXNA1

4.52e-05661219480842
Pubmed

Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.

PLXNA3 PLXNA1

6.32e-05761219063725
Pubmed

Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.

PLXNA3 PLXNA1

6.32e-05761219655386
Pubmed

Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.

PLXNA3 PLXNA1

6.32e-05761210520994
Pubmed

The expression of plexins during mouse embryogenesis.

PLXNA3 PLXNA1

8.42e-05861215661641
Pubmed

Integration of opposing semaphorin guidance cues in cortical axons.

PLXNA3 PLXNA1

8.42e-05861222368082
Pubmed

PlexinA2 and semaphorin signaling during cardiac neural crest development.

PLXNA3 PLXNA1

1.08e-04961211688557
Pubmed

The role of neuropilins in cell signalling.

PLXNA3 PLXNA1

1.08e-04961219909241
Pubmed

A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.

DCAF4 DCAF5

1.08e-04961219966799
Pubmed

Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.

CLSPN BTRC

1.08e-04961219477924
Pubmed

Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development.

PLXNA3 PLXNA1

1.35e-041061218804103
Pubmed

Semaphorin-5B Controls Spiral Ganglion Neuron Branch Refinement during Development.

PLXNA3 PLXNA1

1.65e-041161231209173
Pubmed

Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.

PLXNA3 PLXNA1

1.97e-041261225839327
Pubmed

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.

CLSPN BTRC

1.97e-041261218662541
Pubmed

PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.

PLXNA3 PLXNA1

1.97e-041261231690636
Pubmed

On and off retinal circuit assembly by divergent molecular mechanisms.

PLXNA3 PLXNA1

1.97e-041261224179230
Pubmed

Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels.

PLXNA3 PLXNA1

1.97e-041261228407732
Pubmed

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.

PLXNA3 PLXNA1

1.97e-041261221270798
Pubmed

Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.

PLXNA3 PLXNA1

1.97e-041261223991118
Pubmed

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.

PPP1R12B BTRC

1.97e-041261224785407
Pubmed

Plexin signaling via off-track and rho family GTPases.

PLXNA3 PLXNA1

2.33e-041361211604131
Pubmed

Functional assembly of accessory optic system circuitry critical for compensatory eye movements.

PLXNA3 PLXNA1

2.33e-041361225959730
Pubmed

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

PLXNA3 PLXNA1

2.33e-041361210520995
Pubmed

Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.

PLXNA3 PLXNA1

2.33e-041361222723296
Pubmed

A midline switch of receptor processing regulates commissural axon guidance in vertebrates.

PLXNA3 PLXNA1

2.72e-041461220159958
Pubmed

CUL2LRR1 , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle.

CLSPN CDC45

3.13e-041561233590678
Pubmed

Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing.

ATRN DYSF

3.13e-041561219436707
Pubmed

Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.

PLXNA3 PLXNA1

3.57e-041661218489001
Pubmed

Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.

PLXNA3 PLXNA1

3.57e-041661217356169
Pubmed

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

PLXNA3 PLXNA1

4.05e-041761211683995
Pubmed

Genome-wide association analysis of age-at-onset in Alzheimer's disease.

HRK LEMD2

4.05e-041761222005931
Pubmed

Semaphorin signaling facilitates cleft formation in the developing salivary gland.

PLXNA3 PLXNA1

4.05e-041761217626059
Pubmed

Identification of proteins that may directly interact with human RPA.

CLSPN CDC45

4.05e-041761220679368
Pubmed

Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.

CLSPN CDC45

5.08e-041961215226314
Pubmed

Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.

PLXNA3 PLXNA1

6.22e-042161221835343
Pubmed

DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.

CLSPN CDC45

6.83e-042261215707391
Pubmed

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

CLSPN BTRC

7.48e-042361222017875
Pubmed

A semaphorin code defines subpopulations of spinal motor neurons during mouse development.

PLXNA3 PLXNA1

8.15e-042461215869472
Pubmed

A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis.

PLXNA3 PLXNA1

8.15e-042461228893946
Pubmed

Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.

PLXNA3 PLXNA1

1.11e-032861218617019
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

PLXNA3 ATRN PLXNA1

1.16e-0311761317145500
Pubmed

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.

AMOTL1 RASSF10 RASSF4 BTRC

1.31e-0327061424366813
Pubmed

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

DCAF4 DCAF5

1.45e-033261216964240
Pubmed

FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability.

DCAF4 BTRC

1.45e-033261235813202
Pubmed

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

CLSPN CDC45

1.64e-033461212791985
Cytoband1p32.1

C1orf87 MYSM1

7.76e-05106121p32.1
Cytoband11q14.3

UBTFL1 AMOTL1

8.40e-043261211q14.3
Cytoband10q26.3

C10orf143 LRRC27

2.12e-035161210q26.3
Cytoband1p34.2

CFAP57 CLSPN

2.64e-03576121p34.2
GeneFamilyWD repeat domain containing

WDR7 CFAP57 DCAF4 DCAF5 BTRC

1.05e-04262335362
GeneFamilyPlexins

PLXNA3 PLXNA1

1.15e-049332683
GeneFamilyRas association domain family

RASSF10 RASSF4

1.44e-04103321198
GeneFamilyWD repeat domain containing|DDB1 and CUL4 associated factors

DCAF4 DCAF5

4.85e-0418332498
ComputationalGenes in the cancer module 397.

JMJD4 PADI3 IGSF3 CDC45

2.54e-04121284MODULE_397
DrugFelbinac [5728-52-9]; Down 200; 18.8uM; MCF7; HT_HG-U133A

ATRN ACTR8 JMJD4 GNAS CEP164 BTRC

9.50e-061965765700_DN
Drugindomethacin, USP; Down 200; 100uM; MCF7; HG-U133A

CACTIN LARP6 ATAD2B JMJD4 EVPL PLXNA1

1.01e-05198576453_DN
DrugMelatonin [73-31-4]; Up 200; 17.2uM; MCF7; HT_HG-U133A

LARP6 HRK JMJD4 GNAS CEP164 BTRC

1.01e-051985765393_UP
Diseaseperipheral neuropathy, response to docetaxel trihydrate

C10orf143 TRPM2

6.36e-0419582EFO_0003100, GO_1902519
Diseasealcoholic pancreatitis

C1orf87 DDI2 PLXNA1

9.60e-0498583EFO_1002013
DiseaseMalignant neoplasm of breast

PPM1D C1orf87 PPP1R12B FRMPD1 IRF8 CLSPN DYSF PADI3

1.14e-031074588C0006142
Diseasepeptic ulcer disease

CERKL GNAS

1.93e-0333582MONDO_0004247

Protein segments in the cluster

PeptideGeneStartEntry
MNKSRWQSRRRHGRR

DCAF4

1

Q8WV16
REWQRFGVRMLRERA

ACTR8

606

Q9H981
RMVRTDSLWRGLAER

BTRC

231

Q9Y297
REQMERRLRTWLERE

AMOTL1

626

Q8IY63
WASLRRREMVRSGAR

CCDC14

41

Q49A88
RRKLRDWSLEQMVRG

C1orf87

141

Q8N0U7
QRWMRRRQEELAARE

RASSF10

356

A6NK89
RWNGRILQMLNRLRE

RAD21L1

481

Q9H4I0
WGLRRPIRLQMQDDR

RASSF4

61

Q9H2L5
VRGWLERKRLQRVMT

IQCM

301

A0A1B0GVH7
EAAPSRRWLERMRRT

KCNG3

146

Q8TAE7
WMRRPEQRQGRACIR

MGAT1

291

P26572
PQSRRRMKRVWDRAV

LEMD2

451

Q8NC56
RQNRRSGEVERLRMW

ATAD2B

206

Q9ULI0
WQKLRATDQEMRRER

CFAP57

1026

Q96MR6
SCWASRRREQLLREM

ATRN

1306

O75882
VMWRLFRRRDPQETR

GDF1

61

P27539
LEWRQGRMARIILQD

PLXNA1

1556

Q9UIW2
LEWRQGRMTRIILQD

PLXNA3

1531

P51805
MCDRNGGRRLRQWLI

IRF8

1

Q02556
RARVWEMLNRERTAR

EVPL

1536

Q92817
RRVRENPRDTQLWMA

NRDE2

316

Q9H7Z3
ERRASTWQRNAMRRR

DCAF5

576

Q96JK2
MWGRRRKLRRLNDVT

PMS2P5

1

A8MQ11
PWVRRRRQAEMGTQE

LARP6

431

Q9BRS8
WRQEERLREQEGKMR

GOLGA6L2

296

Q8N9W4
MRWLRPAGRRREQES

LMNTD2

1

Q8IXW0
VNRALGRWRQRMLRA

PPM1D

351

O15297
MERGRERADTRRWRF

PADI3

56

Q9ULW8
MAVRSLWAGRLRVQR

GRPEL2

1

Q8TAA5
EQTMRRRQRREWEAR

CDC45

166

O75419
VDRQNRRSNIMWLDR

IGSF3

451

O75054
HWEARRRQMALDRRR

CCDC200

6

A0A1B0GVQ3
ALQAMRAAIERRWRR

CROCC2

401

H7BZ55
RIEQMVARWLRRSRD

FRMPD1

16

Q5SYB0
RRRVLRPVLSWMDRE

JMJD4

36

Q9H9V9
MDRRSRAQQWRRARH

GNAS

1

O95467
RRRTWSRDEVMGDNL

CEP170P1

111

Q96L14
MPWRRRRNRVSALEG

CERKL

1

Q49MI3
WSLRRRQQLARQARM

HCAR1

201

Q9BXC0
GEEQSRGQWARRRRR

CACTIN

91

Q8WUQ7
ERCNIMRLVDRRWAG

DDI2

266

Q5TDH0
RWVRLRRRDLSQMEA

DYSF

1041

O75923
GDELHQRTMWRRRAR

HRK

41

O00198
RERKMQWVQRQRLER

PNKD

311

Q8N490
RALQEWRERAQRMRK

LRRC27

361

Q9C0I9
RLEKEWMRNRSAARR

ABCC6

251

O95255
RMREEESQRLSWLRA

CEP164

661

Q9UPV0
WGTERIGRRMKRQDQ

C12orf71

61

A8MTZ7
RIEREQWLRDMAQQG

CLSPN

1176

Q9HAW4
MDSLALGRWRQRRAE

C10orf143

1

A0A1B0GUT2
ERMVEIGRRWQRIPQ

UBTFL6

256

P0CB48
SVRERMVEIGRRWQR

UBTFL1

246

P0CB47
RLWDFLRQMVAARRE

SPTBN2

511

O15020
MVTRWRRNEDGAICR

TRPM2

1351

O94759
RGIQRWMRNLREACR

TPBGL

331

P0DKB5
WNKALMENRRRSRQD

TRANK1

601

O15050
SWRRRVGTQMERVRE

TRANK1

2691

O15050
MLARRWQDRCLEVRE

WDR7

1011

Q9Y4E6
VRGWMARRHFQRLRD

MYO5B

871

Q9ULV0
RMRRAEQLRRWRGSL

PPP1R12B

16

O60237
QSMRTRRRRVRDPWG

MYSM1

496

Q5VVJ2