Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncoreceptor activity

RGMB ACVR2A ZP2 RGMA CD22 LRP4

3.15e-06721126GO:0015026
GeneOntologyMolecularFunctionall-trans retinoic acid 18-hydroxylase activity

CYP26B1 CYP26A1

9.32e-0531122GO:0062183
GeneOntologyCellularComponentstereocilium tip

CDH23 PKHD1L1 MYO3A

2.20e-04221133GO:0032426
GeneOntologyCellularComponent3M complex

CCDC8 CUL7

2.87e-0451132GO:1990393
DomainCul7

CUL9 CUL7

1.03e-0431102PF11515
DomainRGM_N

RGMB RGMA

1.03e-0431102IPR010536
DomainRGM_C

RGMB RGMA

1.03e-0431102PF06534
DomainRGM_N

RGMB RGMA

1.03e-0431102PF06535
DomainCPH_domain

CUL9 CUL7

1.03e-0431102IPR021097
DomainRGM_C

RGMB RGMA

1.03e-0431102IPR009496
Domain-

GTF2IRD2B GTF2IRD2

2.05e-04411023.90.1460.10
DomainGTF2I

GTF2IRD2B GTF2IRD2

2.05e-0441102PS51139
DomainGTF2I

GTF2IRD2B GTF2IRD2

2.05e-0441102PF02946
DomainGTF2I

GTF2IRD2B GTF2IRD2

2.05e-0441102IPR004212
DomainAPC_su10/DOC_dom

CUL9 CUL7

7.08e-0471102IPR004939
DomainDOC

CUL9 CUL7

7.08e-0471102PS51284
DomainANAPC10

CUL9 CUL7

7.08e-0471102PF03256
DomainAPC10

CUL9 CUL7

7.08e-0471102SM01337
DomainCullin_neddylation_domain

CUL9 CUL7

9.40e-0481102IPR019559
DomainCullin_Nedd8

CUL9 CUL7

9.40e-0481102PF10557
DomainCullin_Nedd8

CUL9 CUL7

9.40e-0481102SM00884
DomainCullin_homology

CUL9 CUL7

1.20e-0391102IPR016158
DomainCullin

CUL9 CUL7

1.50e-03101102PF00888
DomainCyt_P450_E_grp-IV

CYP26B1 CYP26A1

1.50e-03101102IPR002403
DomainCULLIN_2

CUL9 CUL7

1.50e-03101102PS50069
DomainCullin_N

CUL9 CUL7

1.50e-03101102IPR001373
DomainCULLIN_1

CUL9 CUL7

1.50e-03101102PS01256
DomainAnticodon-bd

PARS2 IMP4

2.99e-03141102IPR004154
DomainKinase-like_dom

ERBB3 MAP3K8 CLK4 CHD9 ACVR2A MYO3A DMPK EIF2AK3 EPHA1

4.74e-035421109IPR011009
DomainRib_L2_dom2

CUL9 CUL7

4.95e-03181102IPR014722
Domain-

CUL9 CUL7

4.95e-031811022.30.30.30
DomainPROTEIN_KINASE_ATP

ERBB3 MAP3K8 CLK4 ACVR2A MYO3A DMPK EIF2AK3 EPHA1

5.78e-034591108PS00107
Pubmed

Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.

CYP26B1 CYP26A1

1.05e-052113222020119
Pubmed

Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1.

CYP26B1 CYP26A1

1.05e-052113226937021
Pubmed

Effects of maternal lead exposure on RGMa and RGMb expression in the hippocampus and cerebral cortex of mouse pups.

RGMB RGMA

1.05e-052113227545491
Pubmed

GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.

GPR89B GPR89A

1.05e-052113222572823
Pubmed

Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains.

RYR1 GPNMB

1.05e-052113221933672
Pubmed

Potential prognostic value of repulsive guidance molecules in breast cancer.

RGMB RGMA

1.05e-052113221617229
Pubmed

Typing classical polymorphisms by real-time PCR: analysis of the GPT and ALAD protein polymorphisms in the Jewish populations.

GPT ALAD

1.05e-052113218432999
Pubmed

Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development.

CYP26B1 CYP26A1

1.05e-052113211520679
Pubmed

Association study between novel CYP26 polymorphisms and the risk of betel quid-related malignant oral disorders.

CYP26B1 CYP26A1

1.05e-052113225839051
Pubmed

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.

GPR89B GPR89A

1.05e-052113218794847
Pubmed

Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

1.05e-052113215388857
Pubmed

Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism.

CYP26B1 CYP26A1

1.05e-052113210823918
Pubmed

The G-patch protein NF-κB-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis.

XRN2 DHX15

3.13e-053113228115624
Pubmed

Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells.

RGMB RGMA

3.13e-053113222076499
Pubmed

The retinoic acid hydroxylase Cyp26a1 has minor effects on postnatal vitamin A homeostasis, but is required for exogenous atRA clearance.

CYP26B1 CYP26A1

3.13e-053113231167781
Pubmed

Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding.

CUL9 CUL7

3.13e-053113217229476
Pubmed

Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development.

CUL9 CUL7

3.13e-053113215964813
Pubmed

Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice.

CYP26B1 CYP26A1

3.13e-053113233105029
Pubmed

The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.

ERBB3 EIF2AK3

3.13e-053113232107308
Pubmed

A rare cause of syndromic short stature: 3M syndrome in three families.

CCDC8 CUL7

3.13e-053113233258289
Pubmed

The genetics of 3-M syndrome: unravelling a potential new regulatory growth pathway.

CCDC8 CUL7

3.13e-053113222156540
Pubmed

The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53.

CUL9 CUL7

3.13e-053113217298945
Pubmed

Isolation and characterisation of GTF2IRD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome.

GTF2IRD2B GTF2IRD2

3.13e-053113215100712
Pubmed

Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis.

CYP26B1 CYP26A1

3.13e-053113211744378
Pubmed

Fluconazole alters CYP26 gene expression in mouse embryos.

CYP26B1 CYP26A1

3.13e-053113219429397
Pubmed

Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development.

RGMB RGMA

3.13e-053113215053976
Pubmed

Three M Syndrome

CCDC8 CUL7

3.13e-053113220301654
Pubmed

Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.

GPR89B GPR89A

3.13e-053113232220963
Pubmed

Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development.

CYP26B1 CYP26A1

3.13e-053113218927157
Pubmed

Exome sequencing identifies CCDC8 mutations in 3-M syndrome, suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth.

CCDC8 CUL7

3.13e-053113221737058
Pubmed

Leukemia Inhibitory Factor Induces Proopiomelanocortin via CRH/CRHR Pathway in Mouse Trophoblast.

CRH LIFR

3.13e-053113234350170
Pubmed

A novel p53-binding domain in CUL7.

CUL9 CUL7

3.13e-053113216875676
Pubmed

Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida.

CYP26B1 CYP26A1

3.13e-053113216933217
Pubmed

Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.

CCDC8 CUL7

3.13e-053113223018678
Pubmed

A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid.

CYP26B1 CYP26A1

3.13e-053113214532297
Pubmed

Cyp26C1 encodes a novel retinoic acid-metabolizing enzyme expressed in the hindbrain, inner ear, first branchial arch and tooth buds during murine development.

CYP26B1 CYP26A1

3.13e-053113212915310
Pubmed

Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases.

CYP26B1 CYP26A1

3.13e-053113231419517
Pubmed

Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick.

CYP26B1 CYP26A1

6.25e-054113217047027
Pubmed

DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties.

RGMB RGMA

6.25e-054113214985445
Pubmed

Generation of activin receptor type IIB isoform-specific hypomorphic alleles.

ACVR2A TMEM163

6.25e-054113216991118
Pubmed

Early reduction of microglia activation by irradiation in a model of chronic glaucoma.

CDH23 GPNMB

6.25e-054113222952717
Pubmed

The 3M complex maintains microtubule and genome integrity.

CCDC8 CUL7

6.25e-054113224793695
Pubmed

TFII-I gene family during tooth development: candidate genes for tooth anomalies in Williams syndrome.

GTF2IRD2B GTF2IRD2

6.25e-054113217823943
Pubmed

Gene expression of the repulsive guidance molecules/neogenin in the developing and mature mouse visual system: C57BL/6J vs. the glaucoma model DBA/2J.

RGMB RGMA

6.25e-054113217942375
Pubmed

Evolution of general transcription factors.

GTF2IRD2B GTF2IRD2

6.25e-054113223229069
Pubmed

GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members.

GTF2IRD2B GTF2IRD2

6.25e-054113222899722
Pubmed

CYP26 Enzymes Are Necessary Within the Postnatal Seminiferous Epithelium for Normal Murine Spermatogenesis.

CYP26B1 CYP26A1

6.25e-054113226040672
Pubmed

A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid.

CYP26B1 CYP26A1

6.25e-054113220375987
Pubmed

Haploinsufficiency of Gtf2i, a gene deleted in Williams Syndrome, leads to increases in social interactions.

GTF2IRD2B GTF2IRD2

6.25e-054113221328569
Pubmed

Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice.

GPR89B GPR89A

6.25e-054113231118204
Pubmed

Association of three candidate genetic variants in ACMSD/TMEM163, GPNMB and BCKDK /STX1B with sporadic Parkinson's disease in Han Chinese.

TMEM163 GPNMB

6.25e-054113230880162
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

GPR89B EPPK1 CHD9 RYR1 HOOK1 GPR89A

6.32e-05208113633230847
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

CUL9 CUL7 LRP4 CLUH PLXNB3

6.86e-05130113512421765
Pubmed

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4.

ACVR2A RGMA

1.04e-045113217472960
Pubmed

A paradoxical teratogenic mechanism for retinoic acid.

CYP26B1 CYP26A1

1.04e-045113222869719
Pubmed

Isolation and expression pattern of three mouse homologues of chick Rgm.

RGMB RGMA

1.04e-045113214678836
Pubmed

Analysis of gene expressions of embryonic stem-derived Pdx1-expressing cells: implications of genes involved in pancreas differentiation.

EPPK1 HKDC1

1.04e-045113219382941
Pubmed

CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.

CUL9 CUL7

1.04e-045113224793696
Pubmed

Gene expression of the repulsive guidance molecules during development of the mouse intestine.

RGMB RGMA

1.04e-045113216032658
Pubmed

PARC and CUL7 form atypical cullin RING ligase complexes.

CUL9 CUL7

1.04e-045113217332328
Pubmed

The response of autologous T cells to a human melanoma is dominated by mutated neoantigens.

UBR4 GPNMB

1.04e-045113216247014
Pubmed

Retinoic acid signaling and the initiation of mammary gland development.

CYP26B1 CYP26A1

1.04e-045113222387209
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

CCDC8 CDH23 ESCO1 FREM1 LIFR

1.43e-04152113534299191
Pubmed

Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis.

CYP26B1 CYP26A1 SBDS

1.55e-0432113317332066
Pubmed

Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.

RYR1 LRP4

1.56e-046113226025922
Pubmed

Dynamic expression of retinoic acid-synthesizing and -metabolizing enzymes in the developing mouse inner ear.

CYP26B1 CYP26A1

1.56e-046113216615129
Pubmed

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.

RGMB RGMA

1.56e-046113233740419
Pubmed

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

RYR1 EIF2AK3

1.56e-046113219009018
Pubmed

Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse.

CYP26B1 CYP26A1

1.56e-046113217435174
Pubmed

Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice.

CYP26B1 CYP26A1

1.56e-046113218816858
Pubmed

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein.

RGMB RGMA

1.56e-046113225938661
Pubmed

KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.

EPPK1 ACOT9 UBR4

1.70e-0433113325582440
Pubmed

The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves.

CYP26B1 CYP26A1

2.17e-047113222972661
Pubmed

Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system.

RGMB RGMA

2.17e-047113214749425
Pubmed

Positive association between ALDH1A2 and schizophrenia in the Chinese population.

CYP26B1 CYP26A1

2.17e-047113219703508
Pubmed

Uncoupling of Natural Killer cell functional maturation and cytolytic function in NOD mice.

GPR84 CDH23

2.17e-047113237536708
Pubmed

Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice.

GPR89B GPR89A

2.17e-047113216015370
Pubmed

CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes.

GPR84 CDH23

2.17e-047113239214091
Pubmed

CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development.

CYP26B1 CYP26A1

2.17e-047113215531370
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

ACP7 AHI1 IARS1 CHD9 NARF DIP2A GTF2IRD2B IMP4 PLCB1 GPR89A BAIAP3

2.19e-049251131128986522
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

CCDC8 XRN2 EPPK1 IARS1 UBR4 CUL9 CUL7 RFC3 DHX15

2.47e-04639113923443559
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

KDM5B ERBB3 XRN2 TRAF3IP1 UBR4 CUL9 CHD9 DIP2A LRP4 ALAD PLXNB3 XPOT SOS2

2.82e-0412851131335914814
Pubmed

DRAGON, a bone morphogenetic protein co-receptor.

RGMB ACVR2A

2.89e-048113215671031
Pubmed

Complementary expression patterns of retinoid acid-synthesizing and -metabolizing enzymes in pre-natal mouse inner ear structures.

CYP26B1 CYP26A1

2.89e-048113215161092
Pubmed

Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes.

CYP26B1 CYP26A1

2.89e-048113228087565
Pubmed

Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development.

CYP26A1 ACVR2A

2.89e-048113220801112
Pubmed

The CXCL12/CXCR4 Axis Plays a Critical Role in Coronary Artery Development.

TMEM163 NOTCH1

2.89e-048113226017770
Pubmed

Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development.

CYP26B1 CYP26A1

2.89e-048113231072004
Pubmed

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.

ERBB3 MAP3K8 CYP26A1 CD22 ALAD DMPK

2.94e-04276113628319085
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

DOCK2 XRN2 EPPK1 ACOT9 IARS1 UBR4 RYR1 DNAH1 DHX15 XPOT

3.10e-048071131030575818
Pubmed

Variable impact of chronic stress on spatial learning and memory in BXD mice.

CADM3 PLCB1

3.71e-049113226079812
Pubmed

Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteins.

ERBB3 MAP3K8

3.71e-04911329070650
Pubmed

Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction.

ERBB3 NOTCH1

3.71e-049113224278323
Pubmed

Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain.

RGMB RGMA

3.71e-049113223457482
Pubmed

Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.

CDH23 MYO3A

3.71e-049113219339464
Pubmed

The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis.

CYP26B1 CYP26A1

3.71e-049113224733397
Pubmed

Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.

TMEM163 EPHA1

4.63e-0410113225073978
Pubmed

Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7.

KPTN DMPK

4.63e-0410113212016511
Pubmed

Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye.

CYP26B1 CYP26A1

4.63e-0410113221148184
Pubmed

Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53.

CUL9 CUL7

5.65e-0411113231570706
GeneFamilyCytochrome P450 family 26

CYP26B1 CYP26A1

4.68e-0537221013
GeneFamilyCullins

CUL9 CUL7

4.31e-0487221032
GeneFamilyDyneins, axonemal

DNAH1 DNAH17

2.05e-0317722536
GeneFamilyOlfactory receptors, family 10

OR10H5 OR10H2 OR10H1

2.32e-0366723157
GeneFamilyAnkyrin repeat domain containing

ASB17 ANKRD66 ASPG ASAP3 NOTCH1

2.78e-03242725403
GeneFamilyFibronectin type III domain containing

FNDC3B LIFR PTPRS EPHA1

3.81e-03160724555
ToppCelldroplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM3 ERBB3 PCDH20 GTF2IRD2 GPNMB UNC80 PLXNB3

4.25e-0718211376fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

BTBD17 CRH CNNM1 RPRM TMEM163 BAIAP3 UNC80

5.68e-071901137b1095b2a7467c152d16e4f19a9515aeb61fc9e3d
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

BTBD17 CRH RPRM HOOK1 FGD4 TMEM163 BAIAP3

6.53e-071941137b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal|6m / Sample Type, Dataset, Time_group, and Cell type.

ERBB3 NWD1 ANKRD66 RYR1 HOOK1 TRPM3 GPNMB

8.01e-07200113713ec8afea86e4a10599c924871ba4e325b0a8013
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NWD1 CYP26B1 ASPG BTBD17 TRPM3 PLCB1

6.48e-0617911367ae67e1c09a4ce9b3bcec4c48ee9cf2b1cb4e339
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SCG5 SELENOM CCDC80 PKHD1L1 ALAD HAS1

6.68e-0618011362ccc77d769d3ffd77ab3af45e4f192785b6db79c
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

CLK4 CCDC80 ARMH1 DNAH1 GPNMB EIF2AK3

7.12e-06182113603992d0ae519795239e4f2cc8e63f33c4482de6a
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A27 NWD1 CYP26B1 SCG5 PKHD1L1 RGMA

7.35e-061831136ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKHD1L1 FREM1 DNAH1 TRPM3 OTOGL UNC80

7.58e-0618411362cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKHD1L1 FREM1 DNAH1 TRPM3 OTOGL UNC80

7.58e-061841136ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKHD1L1 FREM1 DNAH1 TRPM3 OTOGL UNC80

7.58e-0618411362b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ASPG PKHD1L1 HOOK1 CD22 OTOGL HAS1

8.31e-0618711368e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

AHI1 MAP3K8 CYP26A1 PTPN4 HOOK1 HAS1

8.31e-061871136f31d865ce2a21bdf64dbe29ee3e4505ab482604a
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC80 PKHD1L1 RPRM PLCB1 GPNMB HAS1

9.38e-0619111365343a527de6b0f852f45020a91f5b4869e78f13a
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC80 PKHD1L1 RPRM PLCB1 GPNMB HAS1

9.38e-061911136a25a5f9a380031fdaf57677a079f97a90f0550c0
ToppCellPCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ERBB3 EPPK1 MYO3A STXBP2 HOOK1 TMEM163

1.06e-051951136b78db0d929be6b04055805ea5ffecc56c47ba956
ToppCell11.5-Distal-Epithelial-Neuroendocrine|Distal / Age, Tissue, Lineage and Cell class

BTBD17 CRH CNNM1 RPRM HOOK1 TMEM163

1.06e-051951136eda6ebe52c48bd6a9044886e75f584f46c2556e7
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC8 SCG5 CCDC80 ACVR2A RPRM HAS1

1.12e-0519711366b6440f1baad5680cf9e13ca3ab72a2c65523d59
ToppCellBiopsy_Other_PF-Mesenchymal-Mesothelial_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

SCG5 CCDC80 PKHD1L1 RPRM TRPM3 HAS1

1.15e-05198113686736f01e61bf4961f060b24ee1f1f48340737dd
ToppCellMacroglial|World / cells hierarchy compared to all cells using T-Statistic

ERBB3 CD22 LRP4 GPNMB NOTCH1 PLXNB3

1.22e-052001136e6935ad49216d2500c15c05cbc2b89402c65e838
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Macroglial-Astrocyte|10w / Sample Type, Dataset, Time_group, and Cell type.

CYP26B1 BTBD17 CCDC80 RGMA LIFR LRP4

1.22e-05200113675f5ea38fbd341b80a8058077a04447f0e0eea28
ToppCellCOVID-19-Fibroblasts-Mesothelial_FB|COVID-19 / group, cell type (main and fine annotations)

CADM3 CCDC80 PKHD1L1 TRPM3 HAS1

3.01e-0514111357e6dcccb74e7ee90b69dc91b59491b84f3a713c9
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

EPPK1 STXBP5 HKDC1 GPNMB CLUH

3.33e-0514411355e948d4cb913ccd8f82262a1b4d20967aadab3ab
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DOCK2 CRH PCDH20 FREM1 RPRM

3.92e-05149113598ae408d2d0347865875ff8bbd89d359decea526
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NWD1 ASPG ARMH1 RYR1 OTOGL

4.59e-0515411355ed64bbf603290e6dc34f81d145982690b89dd0d
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM3 FNDC3B HKDC1 PKHD1L1 OTOGL

5.50e-05160113556e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM3 FNDC3B HKDC1 PKHD1L1 OTOGL

5.50e-051601135bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCellfacs-Marrow-Granulocytes-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM3 FNDC3B HKDC1 PKHD1L1 OTOGL

5.67e-05161113560f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCellfacs-Heart-RA-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 RYR1 STXBP2 CD22 TMEM163

6.55e-051661135fc2cf67311c86fda75b35fcd4768b6f6f14c59d0
ToppCellfacs-Heart-RA-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK2 RYR1 STXBP2 CD22 TMEM163

6.55e-05166113533a6876d06e26176135a73a77c19e634ec53f7ce
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_3|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

CCDC8 CYP26B1 LIFR RPRM TRPM3

6.74e-0516711355c82d801e3b7d7c6c967a73b94b2ee2a8da1fd6e
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPT PKHD1L1 RPRM TRPM3 OTOGL

7.13e-0516911350cece9b2bb1f58e465c20ec8735a4fc3c1021f03
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPT PKHD1L1 RPRM TRPM3 OTOGL

7.13e-0516911356937c46b119d4ce382fc8c2fa5925ede5ae89c81
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELENOM PKHD1L1 DNAH1 OTOGL UNC80

7.13e-05169113512bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellP07-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CADM3 ERBB3 PCDH20 UNC80 PLXNB3

7.75e-0517211358d6a2a0d5f63b09a5a304a77e600a647f87e9de4
ToppCellfacs-Marrow-B-cells-24m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCG5 SELENOM CDH23 PCDH20 GPNMB

7.75e-05172113565b8935a972bf00b7a10dc2d442128fc0ed78bcb
ToppCellASK454-Epithelial-Transformed_epithelium|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

CCDC80 PKHD1L1 GTF2IRD2B HOOK1 TMEM163

7.75e-0517211353986f0f098ef5e096c8d9ee3d335b8404083701f
ToppCellwk_15-18-Mesenchymal-Fibroblast-Mesenchymal_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CYP26B1 ASPG CYP26A1 RPRM OTOGL

7.96e-051731135b43817a6b1ed8d6b5366702343be4311c0d52d83
ToppCellfacs-Trachea-nan-24m-Mesenchymal-chondrocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASPG CYP26A1 CCDC80 ZP2 GJD4

7.96e-0517311352226505610af1becc253d0a5550627144ef0ed6b
ToppCell(0)_Normal/No_Treatment-(4)_COL2.3+_osteoblasts|(0)_Normal/No_Treatment / Stress and Cell class

SELENOM CCDC80 LIFR PTPRS LRP4

7.96e-051731135c2a0f674681836b5a868c13f67caa7d555ef6519
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC80 RYR1 CD22 TMEM163 HAS1

8.18e-051741135ba909e8789a62968e90bc1c4ab614de738c130f7
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

UBR4 ARMH1 GPNMB CLUH NOTCH1

8.18e-051741135d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC80 RYR1 CD22 TMEM163 HAS1

8.18e-0517411359f7b983459d47b12a1b64e17e29b85a6ff4dc258
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CYP26B1 MAP3K8 RGMA DIP2A TRPM3

8.18e-05174113599eb5e1aee136c7039e23b68a43a0fa3d775859f
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AHI1 SCG5 RPRM TMEM163 UNC80

8.40e-0517511358362a46f5804333baa84cd56d450bc147f372a7e
ToppCellPND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AHI1 SCG5 RPRM TMEM163 UNC80

8.40e-0517511358b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCellLPS-IL1RA+antiTNF|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC25A27 CCDC80 FREM1 LIFR TRPM3

8.87e-051771135b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCG5 BTBD17 CRH CNNM1 HOOK1

8.87e-051771135c80893e5cf5688ee9f5afc8f11b3890f296c9e1f
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_7|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

GPR84 DNAH17 TMEM163 HAS1 CLUH

9.35e-05179113542f3c040f504a91cc69292d39d22b5715c12526f
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_7|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GPR84 DNAH17 TMEM163 HAS1 CLUH

9.35e-051791135063c05753ef1b4a18bc1ebbcae62c8cd25d11070
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CLK4 CCDC80 DNAH1 GPNMB EIF2AK3

9.60e-05180113562511d76d24b836839c3dcc2bf30485ffe9401e2
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CADM3 RGMB CCDC80 CUL7 DNAH1

9.60e-051801135c4068fe47408cfd899131a85fa4b7e5908926f94
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CYP26B1 MAP3K8 DIP2A RPRM TRPM3

9.85e-05181113508f44323bf71b6004a921bbc969c954c75feeb66
ToppCellfacs-Marrow-T-cells-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELENOM CDH23 HOOK1 GPR89A GPNMB

9.85e-05181113557f0cc749ae8b6a3d77e2af31f9a6e4739c57049
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCG5 BTBD17 CNNM1 BAIAP3 UNC80

9.85e-051811135cb17c904ab86d56dd30cac9b61acbb3b76f84ded
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ERBB3 HOOK1 TRPM3 FGD4 PLXNB3

9.85e-051811135fad7ba168f541ac9d04edebc206f191e48bb7e99
ToppCellfacs-Marrow-T-cells-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELENOM CDH23 HOOK1 GPR89A GPNMB

9.85e-051811135d01b35cc2fc57991a35be6a06cb7351fbabd9a11
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CADM3 ERBB3 CYP26A1 PCDH20 PLXNB3

1.01e-041821135a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCellfacs-Marrow-T-cells-3m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELENOM CDH23 RYR1 GPR89A GPNMB

1.04e-041831135b0b835f3b1de1bd46a47e1b805aa8994cd3a4e3e
ToppCell390C-Fibroblasts-Fibroblast-F|390C / Donor, Lineage, Cell class and subclass (all cells)

CADM3 CCDC80 CNNM1 GPNMB HAS1

1.09e-0418511352c1f14f77faeee2acb388d997c5a27a7fef79be1
ToppCell390C-Fibroblasts-Fibroblast-F-|390C / Donor, Lineage, Cell class and subclass (all cells)

CADM3 CCDC80 CNNM1 GPNMB HAS1

1.09e-04185113537db8e0b1f59274227f6fc2362167eb44bd080ef
ToppCellControl-Epithelial-Mesothelial|Epithelial / Disease state, Lineage and Cell class

CADM3 CCDC80 PKHD1L1 PLCB1 HAS1

1.09e-0418511350af540323c0113203ba6c1a4cb32d2fb9cf79d39
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NWD1 HKDC1 LRP4 NOTCH1 PLXNB3

1.12e-04186113541e03be964044dae690d566bd078dab3d8045eba
ToppCellB_cells-Plasma_cells_and_plasmablasts|World / Immune cells in Kidney/Urine in Lupus Nephritis

FNDC3B SELENOM PKHD1L1 CHST15 EIF2AK3

1.15e-0418711359325cadd5f2c667d526696899e7aa36a98226d4b
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BTBD17 CRH RPRM TMEM163 BAIAP3

1.15e-04187113598477ba04a42a8da80a72f41a182429f46283595
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 BOK CD22 LRP4 PLXNB3

1.18e-04188113560242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 CD22 LRP4 NOTCH1 PLXNB3

1.18e-041881135505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 CD22 LRP4 NOTCH1 PLXNB3

1.21e-041891135784ace2be87f2ecb19490f4974f63a559516e0eb
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 CD22 LRP4 NOTCH1 PLXNB3

1.21e-04189113542ab4cc5fbf8580841f31889446fe4499df1a464
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC25A27 CCDC80 ACVR2A FREM1 PTPRS

1.21e-0418911352a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellNeuroendocrine-neuroendo-2-Calca|World / Class top

SCG5 SELENOM TMEM163 DMPK UNC80

1.21e-0418911356baa9a74560121cc008bb8fa9b2b7a335b3aeee0
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 CD22 LRP4 NOTCH1 PLXNB3

1.21e-04189113537ecbd73408d462b47d7e5611f203143e08a2689
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NWD1 RGMA LRP4 NOTCH1 PLXNB3

1.24e-0419011355c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BTBD17 CRH RPRM TMEM163 BAIAP3

1.24e-0419011352375e604eacd38f61f3e661ba2f76d286fcceca7
ToppCelltumor_Lung-Fibroblasts-Mesothelial_cells|Fibroblasts / Location, Cell class and cell subclass

PKHD1L1 RPRM STXBP2 HOOK1 HAS1

1.24e-041901135d82ab67735c1f365d4b0e02b5fa91c64cdc234da
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 CD22 LRP4 NOTCH1 PLXNB3

1.24e-0419011352de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCellControl-Lymphoid-NK|Lymphoid / Disease state, Lineage and Cell class

FNDC3B MAP3K8 DIP2A PTPN4 PLCB1

1.24e-0419011351584c68b58c7f406d9b0e8451beea3e6f8980c56
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 CD22 LRP4 NOTCH1 PLXNB3

1.24e-04190113507f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellIPF-Myeloid-cMonocyte|World / Disease state, Lineage and Cell class

MAP3K8 STXBP2 CHST15 FGD4 PLCB1

1.24e-041901135ffa890138394f579fee53fcfac6c121bf86adc26
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCG5 GPT SELENOM RPRM LRP4

1.24e-04190113519faabab3f27579e380d2ac625876c6439933b44
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM3 SELENOM CCDC80 GPNMB HAS1

1.24e-04190113547077579496c5340e99f61499427a3a36b566da3
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CRH STXBP2 HOOK1 FGD4 TMEM163

1.27e-04191113572dbd2e0fabfca8d6f604df35277d3574739a0b3
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ASPG SCG5 PKHD1L1 HOOK1 HAS1

1.27e-0419111354c4eb61e6179d2f8fc524d2f813db9cba84f67a2
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM3 SELENOM CCDC80 GPNMB HAS1

1.27e-041911135a57cf0519d749febc0b69fe0b098b7ba53d63258
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 CD22 LRP4 GPNMB PLXNB3

1.27e-0419111352110a1dd10730ad7ee7a265fb1716ab3ddafcf4a
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM3 SELENOM CCDC80 GPNMB HAS1

1.27e-04191113519c67a812b8ce97472d316acd15aeefe8736000d
ToppCellwk_08-11-Epithelial-Proximal_epithelial-GHRL+_NE_precursor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

BTBD17 CNNM1 HOOK1 BAIAP3 UNC80

1.27e-041911135f0a81f621e63e87ff62224b33cf0c71dfac1d6e2
ToppCellLV-02._Fibroblast_II|World / Chamber and Cluster_Paper

FNDC3B CHD9 CCDC80 RGMA PLCB1

1.27e-041911135d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SELENOM CCDC80 RGMA GPNMB HAS1

1.27e-0419111354e4488380379ed29d7898bae4e24221e7c67eb9d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 CD22 LRP4 NOTCH1 PLXNB3

1.27e-041911135f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCell(5)_Epi_basal|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

CCDC8 NWD1 CYP26A1 SELENOM CCDC80

1.27e-0419111356bda3d5a8a391d41bb4d65872492e6c094bcc4d4
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RGMB CRH PCDH20 FREM1 MYO3A

1.27e-041911135fa50a3c7ff86e1ee07100da1ace0b0fa1b0ab26b
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 CD22 LRP4 NOTCH1 PLXNB3

1.27e-041911135a90c8ab2077e52bbc998457c85a1b9867f9c8c93
ToppCellwk_20-22-Epithelial-Distal_epithelial_progenitor|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ERBB3 ASPG HKDC1 HOOK1 TMEM163

1.30e-041921135fa2420d6117d4800f60ef6a24bcf8bf54593cd1f
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MAP3K8 DIP2A PTPN4 BOK PLCB1

1.30e-041921135df4741e7684f010445f0224a1fd61aaa4fae02b3
ToppCellwk_20-22-Epithelial-Distal_epithelial_progenitor-epi-tip_late|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ERBB3 ASPG HKDC1 HOOK1 TMEM163

1.30e-04192113587b60014202633a4f6d19b09a5dd9276c2edecfb
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NWD1 RGMA LRP4 NOTCH1 PLXNB3

1.30e-041921135f7e4509003d71f805b9d4587098e90d2897b6739
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ERBB3 MYO3A HOOK1 FGD4 TMEM163

1.30e-041921135d3634574b2e8d2ded6446969361b70761b331aea
ToppCellfacs-Lung-nan-3m-Epithelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB3 EPPK1 GPT RPRM TMEM163

1.30e-041921135cca2d0fedfbd946c54d6f4fc45887117c8dae58a
ToppCellNeuroendocrine|World / Class top

SCG5 SELENOM TMEM163 DMPK UNC80

1.30e-0419211350199da3ef9ddb6673e9aa41f346f374838aec182
ComputationalGenes in the cancer module 136.

SLC25A27 KDM5B XRN2 CDH23 CUL9 CHD9 PARS2 RPRM DHODH BAIAP3 CLUH

1.77e-044916611MODULE_136
ComputationalGenes in the cancer module 317.

SLC25A27 KDM5B XRN2 CUL9 CHD9 PARS2 RPRM DHODH BAIAP3 CLUH

3.21e-044406610MODULE_317
ComputationalGenes in the cancer module 255.

SLC25A27 KDM5B XRN2 CUL9 CHD9 PARS2 RPRM DHODH BAIAP3 CLUH

3.84e-044506610MODULE_255
ComputationalBlood cells and cancer expression cancer.

SLC25A27 KDM5B XRN2 CUL9 CHD9 PARS2 RPRM DHODH BAIAP3 CLUH

5.24e-044686610MODULE_179
ComputationalGenes in the cancer module 37.

SLC25A27 KDM5B XRN2 CUL9 CHD9 PARS2 RPRM DHODH BAIAP3 CLUH

5.50e-044716610MODULE_37
ComputationalBlood cells and cancer expression clusters.

SLC25A27 KDM5B XRN2 CUL9 CHD9 PARS2 RPRM BAIAP3 CLUH

7.99e-04407669MODULE_532
ComputationalGenes in the cancer module 459.

SLC25A27 KDM5B XRN2 CUL9 CHD9 PARS2 RPRM BAIAP3 CLUH

1.20e-03431669MODULE_459
ComputationalGenes in the cancer module 378.

SLC25A27 KDM5B XRN2 CUL9 CHD9 PARS2 RPRM BAIAP3 CLUH

1.28e-03435669MODULE_378
ComputationalGenes in the cancer module 69.

SLC25A27 KDM5B XRN2 CUL9 CHD9 PARS2 RPRM DHODH BAIAP3 CLUH

1.29e-035266610MODULE_69
DrugMethoxamine hydrochloride [61-16-5]; Up 200; 16.2uM; PC3; HT_HG-U133A

CADM3 MAP3K8 ASAP3 ERG28 CD22 PTPRS BAIAP3 SOS2

6.66e-0619811386627_UP
DrugBromopride [4093-35-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A

MAP3K8 RAB11FIP2 ASAP3 CHD9 CUL7 RPRM PLCB1 SOS2

6.91e-0619911384741_DN
DiseaseMiller-McKusick-Malvaux-Syndrome (3M Syndrome)

CCDC8 CUL7

1.38e-0521102C1848862
DiseaseThree M Syndrome 1

CCDC8 CUL7

1.38e-0521102C2678312
Disease3-M syndrome

CCDC8 CUL7

4.12e-0531102cv:C1848862
Disease3-M syndrome (is_implicated_in)

CCDC8 CUL7

4.12e-0531102DOID:0060241 (is_implicated_in)
DiseaseCushing Syndrome

CDH23 CRH

2.05e-0461102C0010481
Diseasecholate measurement

CCDC8 PLCB1

6.08e-04101102EFO_0021509
Diseaseocular hypertension, response to triamcinolone acetonide

CDH23 CHD9 OTOGL

8.20e-04491103EFO_0006954, EFO_1001069
Diseasealcohol use disorder (implicated_via_orthology)

KDM5B ERBB3 RYR1 STXBP2 NOTCH1

8.36e-041951105DOID:1574 (implicated_via_orthology)
Diseaseclonal hematopoiesis mutation measurement

STXBP2 PLCB1 DMPK

1.15e-03551103EFO_0020949
DiseaseSeizures

KMT2E CRH KPTN TRPM3 ALAD

1.37e-032181105C0036572
DiseaseNeoplasm of uncertain or unknown behavior of bladder

ERBB3 NOTCH1

1.40e-03151102C0496930
DiseaseBenign neoplasm of bladder

ERBB3 NOTCH1

1.40e-03151102C0154017
DiseaseCarcinoma in situ of bladder

ERBB3 NOTCH1

1.40e-03151102C0154091
Diseaseobsolete_red blood cell distribution width

FNDC3B XRN2 AHI1 SCG5 CDH23 ARMH1 GTF2IRD2B HOOK1 CD22 SULT2A1 GTF2IRD2 CLUH NOTCH1

1.53e-03134711013EFO_0005192
DiseaseBarrett Epithelium

CYP26A1 RPRM

1.60e-03161102C1258085
DiseaseBarrett Esophagus

CYP26A1 RPRM

1.60e-03161102C0004763
DiseaseCarcinoma of bladder

ERBB3 NOTCH1

2.03e-03181102C0699885
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

CUL7 RYR1 MYO3A ALAD

2.32e-031481104C0279702
DiseaseCleft palate

IARS1 ACVR2A SULT2A1

2.40e-03711103HP_0000175
DiseaseColonic Neoplasms

KDM5B CYP26A1 PLCB1 NOTCH1

2.56e-031521104C0009375
DiseaseMalignant tumor of colon

KDM5B CYP26A1 PLCB1 NOTCH1

3.01e-031591104C0007102
DiseaseDisproportionate short stature

CUL7 LIFR EIF2AK3

3.02e-03771103C0878659
Diseaselymphocyte count

DOCK2 ERBB3 NWD1 EPPK1 HKDC1 CDH23 DIP2A PTPN4 GTF2IRD2B DNAH17 ERCC6L2 GTF2IRD2 PLCB1

3.17e-03146411013EFO_0004587
Diseasevenous thromboembolism, tissue plasminogen activator measurement

STXBP5 LRP4

3.31e-03231102EFO_0004286, EFO_0004791
DiseaseNonsyndromic Deafness

CDH23 MYO3A OTOGL

3.48e-03811103C3711374
DiseaseWest Syndrome

CRH PLCB1

3.60e-03241102C0037769

Protein segments in the cluster

PeptideGeneStartEntry
LTLDGMNPRVRRVEY

GPT

21

P24298
AMRRYLERGESIEPL

ERBB3

676

P21860
ERYQMVLEPRVLLTE

EPHA1

491

P21709
LQPDTTYIVRVRMLT

EPHA1

506

P21709
MPRYRGAALAREEIL

ASAP3

31

Q8TDY4
LRYIPDMETRAGFIE

EIF2AK3

266

Q9NZJ5
LGLRALAPEEVEMLY

BAIAP3

126

O94812
IILYEIPSGRFMREL

AHI1

636

Q8N157
GTRRYMAPEVLEGAI

ACVR2A

361

P27037
IAEELLYLRVVRGLM

ARMH1

316

Q6PIY5
VTLGPQLMEVTVYRR

GPNMB

201

Q14956
AVAERALRAIRYPMI

BTBD17

246

A6NE02
QMEVIRLLIEYGARP

ANKRD66

56

B4E2M5
RRMKDSYIEVLLPLG

ACOT9

81

Q9Y305
GVMEQLGIARPRVEY

SCG5

46

P05408
RIEVLYTPTAMIRPD

CADM3

226

Q8N126
MNDPLLERYGVIILD

DHX15

246

O43143
LRLGDELEMIRPSVY

BOK

71

Q9UMX3
GPMRSSVRVIVYVED

CDH23

1186

Q9H251
YPVVMAREGRAVVTR

ABHD16B

356

Q9H3Z7
AMYEVIDQGPIRRIE

CCDC80

256

Q76M96
PAVELRGMERSLLYT

NWD1

796

Q149M9
EVGPRFELKLYMIRL

IMP4

246

Q96G21
ELMLLVRPNAVYDVV

PTPN4

596

P29074
YLRERPEEARLGMPV

KASH5

16

Q8N6L0
RVGDRFMRLIEPVAA

ACP7

181

Q6ZNF0
GERTPYLIVMGALDR

PCDH20

266

Q8N6Y1
ILYTVAIIPRMLADL

OR10H5

71

Q8NGA6
ILYTVAIIPRMLADL

OR10H2

71

O60403
PFRYLHDIITEVIRM

TRAF3IP1

31

Q8TDR0
LDPMDVRGSIVYLEI

NOTCH1

1666

P46531
MARAVGPERRLLAVY

ASPG

1

Q86U10
YGVKRLEEMLRPLVE

ALAD

56

P13716
VLYPSRVRVMVDREL

ASB17

186

Q8WXJ9
RMAIRVLLGFSIPEE

CYP26B1

191

Q9NR63
PLVAEALDRYIEAMV

KIAA1109

1631

Q2LD37
IITMRGLTTPELRVY

DCAF4L2

101

Q8NA75
LLRMLVIVLAGRPVY

GJD4

31

Q96KN9
DLRGTEIYMSPEVIL

MAP3K8

286

P41279
LREVAGEPLYMLFRA

PLXNB3

1466

Q9ULL4
LVASMLEPAVVYRDL

KPTN

276

Q9Y664
IIRVERRLHEPMYLF

OR51D1

61

Q8NGF3
MVGELRYREFRVPLG

CUL7

1

Q14999
LLGYVVDEMPRSADL

FGD4

691

Q96M96
MLVGLRYLEVEPVSR

ERG28

121

Q9UKR5
VGLLPLEIIRRGYSM

FREM1

1756

Q5H8C1
PDALIIEYRGKFMLR

KMT2E

351

Q8IZD2
LPEGDALRYMIERTV

KDM5B

1246

Q9UGL1
ARPVLLRMGEEYFLR

CRH

61

P06850
VYVLMSGLDLERLVL

IVD

276

P26440
RIPAEMARFYLAEIV

DMPK

166

Q09013
DRIRGRPYTTILMGI

GPR84

171

Q9NQS5
ITLSIVLERMRYEGV

PTPRS

1891

Q13332
LTRMEYIPVAIRTQI

DNAH1

3441

Q9P2D7
ESMYERILTGPVVRE

CHD9

2611

Q3L8U1
IIMPGDVRNDIYITL

DOCK2

416

Q92608
LILAEVAPRYSVMLE

DNAH17

536

Q9UFH2
LLIRMSMPLEYRTII

GPR89A

396

B7ZAQ6
LLIRMSMPLEYRTII

GPR89B

396

P0CG08
VMKDLLPETTYRIRI

FNDC3B

921

Q53EP0
LLYPRARLRVLMVVD

HAS1

121

Q92839
LRVITRLLDFPEAMV

CUL9

1016

Q8IWT3
GERGLLVYPEVKRLM

CYP26A1

171

O43174
ERILAEYPDGRIIMV

ESCO1

656

Q5FWF5
AEIMPVEYREVFIRL

HOOK1

456

Q9UJC3
LVRRMLEYDPTQRIT

CLK4

451

Q9HAZ1
TLELRGMRYHPIDIE

DIP2A

1461

Q14689
RLISLGTVEEIMYLR

ERCC6L2

641

Q5T890
APGYLEISSMRRILE

GTF2IRD2

381

Q86UP8
APGYLEISSMRRILE

GTF2IRD2B

381

Q6EKJ0
MLQIGEDVDYLLIPR

CCDC8

1

Q9H0W5
RPYTVILIERAMKDI

SBDS

126

Q9Y3A5
RRSMLSEYIVPLTPE

RYR1

1726

P21817
TLEVLYAPRRLRVSM

CD22

586

P20273
LLRSMIGYIEELAPI

LIFR

711

P42702
SMASYILVRIPGEII

OTOGL

1556

Q3ZCN5
ILYTVAIIPRMLADL

OR10H1

71

Q9Y4A9
RIMCILRELYGVGVE

RFC3

51

P40938
ERESRAAVLYMVIIP

OR1N2

286

Q8NGR9
LPYTVRAMEKLVRVI

PARS2

91

Q7L3T8
GRYLTLAIRMPEDLA

RGMB

286

Q6NW40
EAVRYVLPRLMLVPV

SOS2

331

Q07890
GRRYEELERIPLSEM

SELENOM

86

Q8WWX9
GMYLGEIVRQILIDL

HKDC1

746

Q2TB90
ISPEALLLMDGVRRY

EPPK1

911

P58107
IREMYALTQGRVPII

DHODH

316

Q02127
IHYLMLPRVREELID

IARS1

801

P41252
RGEGMRYIIILDPAI

SI

1286

P14410
VIYLMRNPRDVLVSG

SULT2A1

116

Q06520
ITEVIPMLEVRLLYE

STXBP5

536

Q5T5C0
VGRYLTFAVRMPEEV

RGMA

286

Q96B86
RLIVMLRDPVERLYS

CHST15

386

Q7LFX5
DGLRSPSEVVYLRME

CNNM1

846

Q9NRU3
MRYLGKVLELVLRSP

CLUH

786

O75153
ESRGLRRYIMEMLPI

UNC80

2556

Q8N2C7
PDERSLYIMRVVQIA

RPRM

46

Q9NS64
IVPTYERMIVFRLGR

STOML1

81

Q9UBI4
EDLIGRDVVRPYQTM

TRPM3

261

Q9HCF6
IEARAGPRLIVYVMG

STXBP2

526

Q15833
IVRPRRLLYMAIDGV

XRN2

91

Q9H0D6
LLIMHRDVIYAVRDP

PPAT

186

Q06203
APYRGMVRTALGIIE

SLC25A27

66

O95847
VRVMEETPSILRVPY

RAB11FIP2

486

Q7L804
VRILRVYIGGMPCEL

PKHD1L1

186

Q86WI1
GRLEQRMITVVYGPD

PLCB1

96

Q9NQ66
GPVERTLYRDVMLEN

ZNF658

26

Q5TYW1
PRGVDLYLRILMAID

XPOT

136

O43592
GPVERTLYRDVMLEN

ZNF782

26

Q6ZMW2
TQEAYEMAVRGLIRP

TRUB2

186

O95900
IERAPSYIEIFGRTM

UBR4

2361

Q5T4S7
AYGVKLLIDMVPRVR

TMEM163

266

Q8TC26
LVRFLRQPIYMEVRV

ZP2

516

Q05996
RIDIRMVSLDIPYFA

LRP4

1056

O75096
LLRQMEGIYADIPVR

NARF

396

Q9UHQ1
LKRGERMSEPLIAYI

MYO3A

116

Q8NEV4