Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-7 ERVK-21 ERVK-9 ERVK-24

7.74e-05371234GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-7 ERVK-21 ERVK-9 ERVK-24

8.61e-05381234GO:0070001
GeneOntologyMolecularFunction6-phosphofructo-2-kinase activity

PFKFB1 PFKFB3

2.24e-0441232GO:0003873
GeneOntologyMolecularFunctionacyltransferase activity

SPTLC3 TRIML1 HECTD3 CUL9 FBXW2 ZZEF1 FBXO30 RBCK1 LTN1 CDYL FBXO27 KAT6B SMURF2 FBXW7

3.01e-0477512314GO:0016746
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

TRIML1 HECTD3 CUL9 FBXW2 ZZEF1 FBXO30 RBCK1 LTN1 FBXO27 SMURF2 FBXW7

3.29e-0451212311GO:0019787
GeneOntologyMolecularFunctionfructose-2,6-bisphosphate 2-phosphatase activity

PFKFB1 PFKFB3

3.72e-0451232GO:0004331
GeneOntologyMolecularFunctionaminoacyltransferase activity

TRIML1 HECTD3 CUL9 FBXW2 ZZEF1 FBXO30 RBCK1 LTN1 FBXO27 SMURF2 FBXW7

4.54e-0453212311GO:0016755
GeneOntologyMolecularFunctionD-mannose binding

MRC1 IGF2R LMAN2

5.99e-04271233GO:0005537
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

TRIML1 HECTD3 CUL9 FBXW2 FBXO30 RBCK1 LTN1 FBXO27 SMURF2 FBXW7

6.98e-0447312310GO:0004842
GeneOntologyMolecularFunctionphosphofructokinase activity

PFKFB1 PFKFB3

7.75e-0471232GO:0008443
GeneOntologyMolecularFunctioncytoskeletal motor activity

MYH3 MYO5B DNAH7 KIF20B DNAH9

8.21e-041181235GO:0003774
GeneOntologyMolecularFunctiontransforming growth factor beta receptor binding

SMURF2 SMAD2 SMAD3

9.04e-04311233GO:0005160
GeneOntologyMolecularFunctionzinc ion binding

AARS1 TUT4 CUL9 CPB2 ERVK-7 ERVK-21 ERVK-9 ZZEF1 FBXO30 LTN1 MTR ERVK-5 ERVK-24 SMAD3

1.18e-0389112314GO:0008270
HumanPhenoIntestinal malrotation

CENPF ODAD4 HIRA SETD5 PI4KA KAT6B DNAH9 SMAD2

1.86e-05157398HP:0002566
DomainAPC_su10/DOC_dom

HECTD3 CUL9 ZZEF1

8.45e-0671183IPR004939
DomainDOC

HECTD3 CUL9 ZZEF1

8.45e-0671183PS51284
DomainANAPC10

HECTD3 CUL9 ZZEF1

8.45e-0671183PF03256
DomainAPC10

HECTD3 CUL9 ZZEF1

8.45e-0671183SM01337
DomainSMK-1

PPP4R3A PPP4R3B

3.96e-0521182PF04802
DomainDUF625

PPP4R3A PPP4R3B

3.96e-0521182IPR006887
DomainKringle-like

MRC1 PRSS12 IGF2R LY75

4.75e-05321184IPR013806
DomainFN_type2_col-bd

MRC1 IGF2R LY75

8.51e-05141183IPR000562
DomainFN2_2

MRC1 IGF2R LY75

8.51e-05141183PS51092
DomainFN2_1

MRC1 IGF2R LY75

8.51e-05141183PS00023
Domainfn2

MRC1 IGF2R LY75

8.51e-05141183PF00040
DomainFN2

MRC1 IGF2R LY75

8.51e-05141183SM00059
DomainLH2

PNLIP PNLIPRP1 PKD1L2

1.87e-04181183SM00308
Domain6Phosfructo_kin

PFKFB1 PFKFB3

2.36e-0441182IPR013079
DomainLipase_panc

PNLIP PNLIPRP1

2.36e-0441182IPR002331
Domain6Pfruct_kin

PFKFB1 PFKFB3

2.36e-0441182IPR003094
Domain6PF2K

PFKFB1 PFKFB3

2.36e-0441182PF01591
Domain-

PNLIP PNLIPRP1 PKD1L2

3.01e-042111832.60.60.20
DomainPLAT

PNLIP PNLIPRP1 PKD1L2

3.01e-04211183PF01477
DomainPLAT/LH2_dom

PNLIP PNLIPRP1 PKD1L2

3.01e-04211183IPR001024
DomainPLAT

PNLIP PNLIPRP1 PKD1L2

3.01e-04211183PS50095
DomainARM-type_fold

USP34 RAP1GDS1 VEPH1 ARFGEF1 CUL9 PPP4R3A PPP4R3B PI4KA LTN1

3.03e-043391189IPR016024
DomainFBOX

FBXW2 FBXO30 FBXO27 FBXW7

3.24e-04521184SM00256
DomainSRCR

PRSS12 PGBD1 CD5L

6.44e-04271183IPR001190
DomainF-box

FBXW2 FBXO30 FBXO27 FBXW7

8.54e-04671184PF00646
DomainDWB

SMAD2 SMAD3

1.08e-0381182SM00524
DomainMH2

SMAD2 SMAD3

1.08e-0381182PS51076
DomainMH1

SMAD2 SMAD3

1.08e-0381182PS51075
Domain-

SMAD2 SMAD3

1.08e-03811823.90.520.10
DomainMAD_homology_MH1

SMAD2 SMAD3

1.08e-0381182IPR013019
DomainDwarfin

SMAD2 SMAD3

1.08e-0381182IPR013790
DomainMH2

SMAD2 SMAD3

1.08e-0381182PF03166
DomainSMAD_dom_Dwarfin-type

SMAD2 SMAD3

1.08e-0381182IPR001132
DomainFBOX

FBXW2 FBXO30 FBXO27 FBXW7

1.12e-03721184PS50181
Domain-

HECTD3 CUL9 ZZEF1 FBXO27

1.18e-037311842.60.120.260
Domain-

SEMA4B COPA EML2 FBXW2 SEC31A HIRA SEC13 FBXW7

1.26e-0333311882.130.10.10
DomainWD40

COPA EML2 FBXW2 SEC31A HIRA SEC13 FBXW7

1.30e-032591187PF00400
DomainF-box_dom

FBXW2 FBXO30 FBXO27 FBXW7

1.30e-03751184IPR001810
DomainWD40/YVTN_repeat-like_dom

SEMA4B COPA EML2 FBXW2 SEC31A HIRA SEC13 FBXW7

1.30e-033351188IPR015943
DomainPG/BPGM_mutase_AS

PFKFB1 PFKFB3

1.38e-0391182IPR001345
DomainWD40

COPA EML2 FBXW2 SEC31A HIRA SEC13 FBXW7

1.58e-032681187SM00320
DomainWD40_repeat

COPA EML2 FBXW2 SEC31A HIRA SEC13 FBXW7

1.72e-032721187IPR001680
DomainLipase/vitellogenin

PNLIP PNLIPRP1

1.72e-03101182IPR013818
DomainTAG_lipase

PNLIP PNLIPRP1

1.72e-03101182IPR000734
DomainLipase

PNLIP PNLIPRP1

1.72e-03101182PF00151
DomainLipase_N

PNLIP PNLIPRP1

1.72e-03101182IPR033906
DomainPGAM

PFKFB1 PFKFB3

1.72e-03101182SM00855
DomainLipase_LIPH

PNLIP PNLIPRP1

1.72e-03101182IPR016272
DomainPG_MUTASE

PFKFB1 PFKFB3

1.72e-03101182PS00175
DomainWD_REPEATS_1

COPA EML2 FBXW2 SEC31A HIRA SEC13 FBXW7

1.94e-032781187PS00678
DomainWD_REPEATS_2

COPA EML2 FBXW2 SEC31A HIRA SEC13 FBXW7

1.98e-032791187PS50082
DomainWD_REPEATS_REGION

COPA EML2 FBXW2 SEC31A HIRA SEC13 FBXW7

1.98e-032791187PS50294
DomainMAD_homology1_Dwarfin-type

SMAD2 SMAD3

2.51e-03121182IPR003619
DomainDWA

SMAD2 SMAD3

2.51e-03121182SM00523
DomainHis_Pase_superF_clade-1

PFKFB1 PFKFB3

2.51e-03121182IPR013078
DomainHis_Phos_1

PFKFB1 PFKFB3

2.51e-03121182PF00300
DomainMH1

SMAD2 SMAD3

2.51e-03121182PF03165
DomainWD40_repeat_dom

COPA EML2 FBXW2 SEC31A HIRA SEC13 FBXW7

2.81e-032971187IPR017986
Domain-

MRC1 IGF2R

2.95e-031311822.10.10.10
DomainWH1

PPP4R3A PPP4R3B

2.95e-03131182PS50229
DomainGalactose-bd-like

HECTD3 CUL9 ZZEF1 FBXO27

2.98e-03941184IPR008979
DomainDynein_heavy_chain_D4_dom

DNAH7 DNAH9

3.43e-03141182IPR024317
DomainDynein_HC_stalk

DNAH7 DNAH9

3.43e-03141182IPR024743
DomainDynein_heavy_dom-2

DNAH7 DNAH9

3.43e-03141182IPR013602
DomainDHC_N2

DNAH7 DNAH9

3.43e-03141182PF08393
DomainIBR

CUL9 RBCK1

3.43e-03141182PF01485
DomainMT

DNAH7 DNAH9

3.43e-03141182PF12777
DomainAAA_8

DNAH7 DNAH9

3.43e-03141182PF12780
DomainDHC_fam

DNAH7 DNAH9

3.94e-03151182IPR026983
DomainDynein_heavy

DNAH7 DNAH9

3.94e-03151182PF03028
DomainIBR_dom

CUL9 RBCK1

3.94e-03151182IPR002867
DomainDynein_heavy_dom

DNAH7 DNAH9

3.94e-03151182IPR004273
DomainSMAD_dom-like

SMAD2 SMAD3

4.48e-03161182IPR017855
Domain-

SMAD2 SMAD3

4.48e-031611822.60.200.10
PathwayREACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

MRC1 HECTD3 FBXW2 NCF2 SEC31A ITGB5 FBXO30 RBCK1 LTN1 FBXO27 SMURF2 SEC13 FBXW7

4.25e-073818513M1066
PathwayREACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION

MRC1 HECTD3 FBXW2 NCF2 SEC31A FBXO30 RBCK1 LTN1 FBXO27 SMURF2 SEC13 FBXW7

9.49e-073438512MM15712
PathwayREACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER

ZFYVE9 SMAD2 SMAD3

7.28e-067853M29623
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

ITGB5 ZFYVE9 SMURF2 SMAD2 SMAD3

8.90e-0647855M646
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER

ZFYVE9 SMAD2 SMAD3

1.16e-058853M27246
PathwayREACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING

ZFYVE9 SMURF2 SMAD2 SMAD3

1.66e-0526854M628
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

ZFYVE9 SMURF2 SMAD2 SMAD3

7.77e-0538854MM14874
PathwayREACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING

SMURF2 SMAD2 SMAD3

1.12e-0416853MM14873
PathwayBIOCARTA_TGFB_PATHWAY

ZFYVE9 SMAD2 SMAD3

1.91e-0419853M18933
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

ITGB5 ZFYVE9 SMURF2 SMAD2 SMAD3

2.55e-0494855M1041
PathwayPID_TGFBR_PATHWAY

ZFYVE9 SMURF2 SMAD2 SMAD3

3.09e-0454854M286
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

MRC1 HECTD3 FBXW2 NCF2 SEC31A ITGAL FBXO30 RBCK1 LTN1 FBXO27 SMURF2 SEC13 FBXW7

3.50e-047198513MM14540
PathwayREACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY

SMURF2 SMAD2 SMAD3

3.91e-0424853MM14877
PathwayREACTOME_ADAPTIVE_IMMUNE_SYSTEM

MRC1 HECTD3 FBXW2 NCF2 SEC31A ITGAL ITGB5 FBXO30 RBCK1 LTN1 FBXO27 SMURF2 SEC13 FBXW7

4.01e-048288514M1058
PathwayREACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

HECTD3 FBXW2 FBXO30 RBCK1 LTN1 FBXO27 SMURF2 FBXW7

4.36e-04299858MM15711
PathwayREACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION

HECTD3 FBXW2 FBXO30 RBCK1 LTN1 FBXO27 SMURF2 FBXW7

5.31e-04308858M1070
PathwayREACTOME_DIGESTION_OF_DIETARY_LIPID

PNLIP PNLIPRP1

5.31e-046852MM14738
PathwayREACTOME_SIGNALING_BY_NODAL

SMAD2 SMAD3

5.31e-046852MM14517
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES

SMAD2 SMAD3

7.40e-047852MM15661
PathwayREACTOME_DIGESTION_OF_DIETARY_LIPID

PNLIP PNLIPRP1

7.40e-047852M27069
PathwayREACTOME_COPII_MEDIATED_VESICLE_TRANSPORT

SEC31A LMAN2 TRAPPC9 SEC13

7.90e-0469854M27113
PathwayREACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY

SMURF2 SMAD2 SMAD3

8.42e-0431853M669
PathwayKEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY

SMAD2 SMAD3

9.83e-048852M47415
PathwayKEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY

SMAD2 SMAD3

9.83e-048852M47849
PathwayKEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY

SMAD2 SMAD3

9.83e-048852M47846
PathwayREACTOME_CROSS_PRESENTATION_OF_PARTICULATE_EXOGENOUS_ANTIGENS_PHAGOSOMES

NCF2 ITGB5

9.83e-048852M26926
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

ZFYVE9 SMURF2 SMAD2 SMAD3

1.19e-0377854MM14670
PathwayREACTOME_COPII_MEDIATED_VESICLE_TRANSPORT

SEC31A LMAN2 TRAPPC9 SEC13

1.57e-0383854MM14819
Pubmed

Role of SARA (SMAD anchor for receptor activation) in maintenance of epithelial cell phenotype.

ZFYVE9 SMURF2 SMAD2 SMAD3

1.64e-104126419620243
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CNTN4 SEMA4B MYO5B DIS3L ZNF618 MAGI3 PPP4R3A FAN1 SACS SPON1 LTN1 PLEKHH2 EXOC7 TRAPPC9

3.57e-094931261415368895
Pubmed

Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.

SMURF2 SMAD2 SMAD3

1.85e-074126319122240
Pubmed

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling.

SMURF2 SMAD2 SMAD3

1.85e-074126311016919
Pubmed

TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.

SMURF2 SMAD2 SMAD3

1.85e-074126311389444
Pubmed

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.

SMURF2 SMAD2 SMAD3

1.85e-074126311158580
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

USP34 CNTN4 AARS1 RAP1GDS1 COPA DSP DIS3L NAP1L2 CUL9 MAGI3 SEC31A RBCK1 FAN1 PPP4R3B SACS SENP6 EXOC7 SMURF2 SMAD2

1.99e-0712851261935914814
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

COPA MYO5B DSP PPP4R3A NSD3 FAN1 PPP4R3B IGF2R TBC1D4 ZFYVE9 PRPF3 PI4KA LTN1 KCNMA1 MACROH2A2 LZTS2 FBXW7

2.63e-0710491261727880917
Pubmed

Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation.

SMURF2 SMAD2 SMAD3

4.62e-075126316959829
Pubmed

Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3.

SMURF2 SMAD2 SMAD3

4.62e-075126322045334
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

USP34 TRIML1 TUT4 HECTD3 DIS3L ZNF618 CUL9 ZZEF1 NSD3 SETD5 PRPF3 LTN1 SMARCA1 MTR MACROH2A2 LZTS2 KAT6B

6.20e-0711161261731753913
Pubmed

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.

FBXW2 FBXO30 RBCK1 FBXO27 SMURF2 FBXW7

6.94e-0785126619028597
Pubmed

Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases.

ZFYVE9 SMAD2 SMAD3

9.21e-076126311100470
Pubmed

Cytoplasmic PML function in TGF-beta signalling.

ZFYVE9 SMAD2 SMAD3

9.21e-076126315356634
Pubmed

Hepatitis C virus/human interactome identifies SMURF2 and the viral protease as critical elements for the control of TGF-β signaling.

SMURF2 SMAD2 SMAD3

9.21e-076126323781096
Pubmed

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.

ZFYVE9 SMAD2 SMAD3

9.21e-07612639865696
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

USP34 AARS1 COPA HECTD3 TTC4 IGF2R TBC1D4 PI4KA MTR LMAN2 LZTS2 SEC13

1.22e-065711261237167062
Pubmed

CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription.

SMURF2 SMAD2 SMAD3

1.61e-067126314701756
Pubmed

Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.

ZFYVE9 SMAD2 SMAD3

1.61e-067126311094085
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

USP34 DSP CUL9 TTC4 KIF20B PPP4R3A PPP4R3B TBC1D4 PI4KA MTR SENP6 LZTS2

1.65e-065881261238580884
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

USP34 DDN SACS SPON1 LTN1 SENP6

1.92e-0610112669872452
Pubmed

Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.

SMURF2 SMAD2 SMAD3

2.57e-068126328881580
Pubmed

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma.

SMURF2 SMAD2 SMAD3

2.57e-068126322344298
Pubmed

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.

SMURF2 SMAD2 SMAD3

3.84e-069126315496141
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

USP34 COPA TTC4 LZTS1 PI4KA SMAD2 SMAD3 SEC13

4.72e-06257126830945288
Pubmed

DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells.

FBXW2 FBXO30 FBXW7

5.47e-0610126331210753
Pubmed

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

SMURF2 SMAD2 SMAD3

5.47e-0610126315221015
Pubmed

The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development.

LZTS3 LZTS1 LZTS2

7.50e-0611126321949185
Pubmed

Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant.

SMURF2 SMAD2 SMAD3

9.97e-0612126319580641
Pubmed

Lack of extracellular matrix switches TGF-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition.

SMAD2 SMAD3

1.30e-052126236050359
Pubmed

Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development.

SMAD2 SMAD3

1.30e-052126211984875
Pubmed

Polycomb determines responses to smad2/3 signaling in embryonic stem cell differentiation and in reprogramming.

SMAD2 SMAD3

1.30e-052126223666711
Pubmed

Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects.

PPP4R3A PPP4R3B

1.30e-052126216107728
Pubmed

Phosphorylated Smad2/3 immunoreactivity in sporadic and familial amyotrophic lateral sclerosis and its mouse model.

SMAD2 SMAD3

1.30e-052126218210139
Pubmed

Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis.

SMAD2 SMAD3

1.30e-052126220010874
Pubmed

Smurf2 Regulates Inflammation and Collagen Processing in Cutaneous Wound Healing through Transforming Growth Factor-β/Smad3 Signaling.

SMURF2 SMAD3

1.30e-052126236063900
Pubmed

Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation.

SMAD2 SMAD3

1.30e-052126216382155
Pubmed

Structure of the Sec13/31 COPII coat cage.

SEC31A SEC13

1.30e-052126216407955
Pubmed

Evidence for a role of Smad3 and Smad2 in stabilization of the tumor-derived mutant Smad2.Q407R.

SMAD2 SMAD3

1.30e-052126212700238
Pubmed

Asthma-derived fibroblast to myofibroblast transition is enhanced in comparison to fibroblasts derived from non-asthmatic patients in 3D in vitro culture due to Smad2/3 signalling.

SMAD2 SMAD3

1.30e-052126233245228
Pubmed

Formation of the definitive endoderm in mouse is a Smad2-dependent process.

SMAD2 SMAD3

1.30e-052126210862745
Pubmed

Smad2-dependent downregulation of miR-30 is required for TGF-β-induced apoptosis in podocytes.

SMAD2 SMAD3

1.30e-052126224086574
Pubmed

Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2.

SMURF2 SMAD2

1.30e-052126235509688
Pubmed

Specific Smad2/3 Linker Phosphorylation Indicates Esophageal Non-neoplastic and Neoplastic Stem-Like Cells and Neoplastic Development.

SMAD2 SMAD3

1.30e-052126232705438
Pubmed

Smad2/3 Linker Phosphorylation Is a Possible Marker of Pancreatic Stem/Progenitor Cells in the Regenerative Phase of Acute Pancreatitis.

SMAD2 SMAD3

1.30e-052126228099259
Pubmed

Arsenite Disrupts Zinc-Dependent TGFβ2-SMAD Activity During Murine Cardiac Progenitor Cell Differentiation.

SMAD2 SMAD3

1.30e-052126226354774
Pubmed

Differential effects of Smad2 and Smad3 in regulation of macrophage phenotype and function in the infarcted myocardium.

SMAD2 SMAD3

1.30e-052126235780861
Pubmed

Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.

SMAD2 SMAD3

1.30e-052126229174331
Pubmed

SMAD2/3 Phosphorylation Is Downregulated in T Cells in HIV-Infected Patients.

SMAD2 SMAD3

1.30e-052126236226468
Pubmed

Phosphorylation of Smad2/3 at specific linker threonine indicates slow-cycling intestinal stem-like cells before reentry to cell cycle.

SMAD2 SMAD3

1.30e-052126225185661
Pubmed

Increased TGF-β1-mediated suppression of growth and motility in castrate-resistant prostate cancer cells is consistent with Smad2/3 signaling.

SMAD2 SMAD3

1.30e-052126222228025
Pubmed

Oocyte-secreted factor activation of SMAD 2/3 signaling enables initiation of mouse cumulus cell expansion.

SMAD2 SMAD3

1.30e-052126217192514
Pubmed

Structural basis of Smad2 recognition by the Smad anchor for receptor activation.

ZFYVE9 SMAD2

1.30e-052126210615055
Pubmed

TGFβ pathway deregulation and abnormal phospho-SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis-Dutch type.

SMAD2 SMAD3

1.30e-052126228557134
Pubmed

Differential activation of noncanonical SMAD2/SMAD3 signaling by bone morphogenetic proteins causes disproportionate induction of hyaluronan production in immortalized human granulosa cells.

SMAD2 SMAD3

1.30e-052126226992562
Pubmed

Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury.

SMAD2 SMAD3

1.30e-052126215972691
Pubmed

Enrichment of human ESC-derived multipotent mesenchymal stem cells with immunosuppressive and anti-inflammatory properties capable to protect against experimental inflammatory bowel disease.

SMAD2 SMAD3

1.30e-052126221732483
Pubmed

Smad2 and 3 transcription factors control muscle mass in adulthood.

SMAD2 SMAD3

1.30e-052126219357234
Pubmed

Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification.

SMAD2 SMAD3

1.30e-052126226905010
Pubmed

Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells.

SMAD2 SMAD3

1.30e-052126221496353
Pubmed

Reduction of Smad2 caused by oxidative stress leads to necrotic death of hypertrophic chondrocytes associated with an endemic osteoarthritis.

SMAD2 SMAD3

1.30e-052126233769459
Pubmed

Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis.

SMAD2 SMAD3

1.30e-052126215665291
Pubmed

Inhibiting Smad2/3 signaling in pluripotent mouse embryonic stem cells enhances endoderm formation by increasing transcriptional priming of lineage-specifying target genes.

SMAD2 SMAD3

1.30e-052126227012147
Pubmed

Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro.

SMAD2 SMAD3

1.30e-052126224925688
Pubmed

Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo.

SMAD2 SMAD3

1.30e-052126215520018
Pubmed

Nuclear exclusion of SMAD2/3 in granulosa cells is associated with primordial follicle activation in the mouse ovary.

SMAD2 SMAD3

1.30e-052126230111581
Pubmed

The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.

SMAD2 SMAD3

1.30e-052126217074756
Pubmed

Molecular validation of the precision-cut kidney slice (PCKS) model of renal fibrosis through assessment of TGF-β1-induced Smad and p38/ERK signaling.

SMAD2 SMAD3

1.30e-052126226919280
Pubmed

Smad2 and Smad3 expressed in skeletal muscle promote immobilization-induced bone atrophy in mice.

SMAD2 SMAD3

1.30e-052126234710825
Pubmed

Smad Anchor for Receptor Activation and Phospho-Smad3 Were Upregulated in Patients with Temporal Lobe Epilepsy.

ZFYVE9 SMAD3

1.30e-052126230847724
Pubmed

Signaling via Smad2 and Smad3 is dispensable for adult murine hematopoietic stem cell function in vivo.

SMAD2 SMAD3

1.30e-052126228666967
Pubmed

The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis.

SMAD2 SMAD3

1.30e-052126221229365
Pubmed

Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation.

SMAD2 SMAD3

1.30e-052126222385658
Pubmed

Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.

SMAD2 SMAD3

1.30e-052126215630024
Pubmed

Implication of Smad2 and Smad3 in transforming growth factor-β-induced posterior capsular opacification of human lens epithelial cells.

SMAD2 SMAD3

1.30e-052126224911914
Pubmed

Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells.

SMAD2 SMAD3

1.30e-052126219172185
Pubmed

The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling.

SMAD2 SMAD3

1.30e-052126211937490
Pubmed

The roles of Smad2 and Smad3 in the development of chemically induced skin tumors in mice.

SMAD2 SMAD3

1.30e-052126215133179
Pubmed

Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion.

SEC31A SEC13

1.30e-052126222331354
Pubmed

Oocytes determine cumulus cell lineage in mouse ovarian follicles.

SMAD2 SMAD3

1.30e-052126217389684
Pubmed

[Expression and significance of Smad2/3 and HPV16 E7 in cervical intraepithelial neoplasia and cervical carcinoma].

SMAD2 SMAD3

1.30e-052126217927854
Pubmed

Hydrophobic patches on SMAD2 and SMAD3 determine selective binding to cofactors.

SMAD2 SMAD3

1.30e-052126229588413
Pubmed

Neovibsanin B increases extracellular matrix proteins in optic nerve head cells via activation of Smad signalling pathway.

SMAD2 SMAD3

1.30e-052126226045877
Pubmed

Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis.

SMAD2 SMAD3

1.30e-052126234445177
Pubmed

Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity.

ZFYVE9 SMAD2

1.30e-052126215231848
Pubmed

Essential role of Smad3 in angiotensin II-induced vascular fibrosis.

SMAD2 SMAD3

1.30e-052126216556868
Pubmed

Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle.

SMAD2 SMAD3

1.30e-052126221883378
Pubmed

Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation.

SMURF2 SMAD2

1.30e-052126235379779
Pubmed

[The roles of Smad 2/3 in transforming growth factor-beta 1 signaling in human dental pulp cells].

SMAD2 SMAD3

1.30e-052126212760775
Pubmed

Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia.

SMAD2 SMAD3

1.30e-052126232733385
Pubmed

Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.

SMAD2 SMAD3

1.30e-052126225908723
Pubmed

Expression pattern and phosphorylation status of Smad2/3 in different subtypes of human first trimester trophoblast.

SMAD2 SMAD3

1.30e-052126228864007
Pubmed

F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression.

FBXW2 FBXO30 FBXW7

1.64e-0514126326087183
Pubmed

Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins.

RBCK1 SMAD2 SMAD3

1.64e-0514126329146913
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

TUT4 COPA DSP CNTRL SEC31A LGALS3 PRPF3 PI4KA ROS1 PLEKHH2 MAP3K19 SEC13

2.02e-057541261235906200
Pubmed

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

MRC1 PNLIP PNLIPRP1 PFKFB3 KIF20B KCNMA1 MACROH2A2 LZTS2 KAT6B

2.17e-05415126916385451
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-7 ERVK-21 ERVK-9 ERVK-5 ERVK-24

2.44e-0594126521542922
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

SPTLC3 TUT4 RASA3 MAGI3 PFKFB1 ITGB5 TBC1D4 SETD5 PRPF3 KCNMA1 MACROH2A2 LZTS2 KAT6B SMURF2 TRAPPC9 VPS13B EPB41

2.78e-0514891261728611215
Pubmed

Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity.

MYO5B EPB41 SMAD3

3.64e-0518126315527767
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-24

3.64e-0518126318664271
InteractionRASL12 interactions

RAP1GDS1 SMURF2 SMAD2 SMAD3

5.20e-06201194int:RASL12
InteractionRASD2 interactions

RAP1GDS1 SMURF2 SMAD2 SMAD3

1.33e-05251194int:RASD2
CytobandEnsembl 112 genes in cytogenetic band chr1p32

TUT4 C1orf87 MRPL37 TTC4 ZFYVE9

7.50e-051551275chr1p32
Cytoband1p32.1

C1orf87 MRPL37

3.37e-041012721p32.1
Cytoband1p32.3

TUT4 TTC4 ZFYVE9

6.62e-046112731p32.3
GeneFamilyLeucine zipper tumor suppressor family

LZTS3 LZTS1 LZTS2

4.00e-0748531314
GeneFamily6-phosphofructo-2-kinases/fructose-2,6-biphosphatases

PFKFB1 PFKFB3

1.30e-0448521077
GeneFamilyWD repeat domain containing

COPA EML2 FBXW2 SEC31A HIRA SEC13 FBXW7

2.34e-04262857362
GeneFamilySMAD family

SMAD2 SMAD3

6.00e-048852750
GeneFamilyWD repeat domain containing|F-box and WD repeat domain containing

FBXW2 FBXW7

1.17e-0311852559
GeneFamilyTrafficking protein particle complex

TRAPPC11 TRAPPC9

1.92e-0314852772
GeneFamilyDyneins, axonemal

DNAH7 DNAH9

2.84e-0317852536
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

USP34 TUT4 CENPF ARFGEF1 SPG11 ZZEF1 KIF20B HIRA IGF2R ZFYVE9 SACS LTN1 SMARCA1 MTR CDYL KAT6B SMURF2 VPS13B SMAD3

9.43e-0985611819M4500
CoexpressionDAZARD_RESPONSE_TO_UV_NHEK_DN

DMTF1 TUT4 CENPF PRSS12 SACS CDYL KAT6B VPS13B SMAD3

8.98e-063001189M8702
CoexpressionFOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_UP

FCRL2 MYO5B DSP NAP1L2 FSD1L TBC1D4 SPON1 SMARCA1 MTR KAT6B SMURF2 SMAD3

1.40e-0558711812M40869
CoexpressionBLANCO_MELO_SARS_COV_1_INFECTION_MCR5_CELLS_UP

CENPF KIF20B CCDC144A

1.90e-05121183M34000
CoexpressionGSE6092_UNSTIM_VS_IFNG_STIM_ENDOTHELIAL_CELL_DN

PRSS12 ZNF229 PPP4R3A NSD3 VPS13B EPB41 FBXW7

3.39e-051991187M6711
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

TUT4 CENPF ARFGEF1 KIF20B HIRA ZFYVE9 CDYL KAT6B SMURF2 SMAD3

5.04e-0546611810M13522
CoexpressionAtlasdev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000

CNTN4 TUT4 PNLIP PNLIPRP1 MYO5B RASA3 DSP ZNF618 ARFGEF1 DNAH7 ITGB5 TBC1D4 LZTS1 SMARCA1 MTR PLEKHH2 ATP1B2 KAT6B

3.28e-0779111718gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_1000
CoexpressionAtlasdev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_200

PNLIP PNLIPRP1 MYO5B RASA3 DNAH7 SMARCA1 MTR ATP1B2

4.86e-061711178gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_200
CoexpressionAtlasdev gonad_e11.5_F_GonadVasMes_Flk_top-relative-expression-ranked_1000

CNTN4 TUT4 PNLIP PNLIPRP1 MYO5B RASA3 CENPF ZNF618 DNAH7 IGF2R LTN1 SMARCA1 MTR PLEKHH2 ATP1B2 KAT6B

1.31e-0583111716gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_1000
CoexpressionAtlasdev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#1_top-relative-expression-ranked_1000

CNTN4 PNLIP PNLIPRP1 MYO5B RASA3 DNAH7 MTR KAT6B

3.44e-052241178gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k1_1000
CoexpressionAtlasdev gonad_e11.5_M_GonMes_Sma_k-means-cluster#4_top-relative-expression-ranked_1000

CNTN4 PNLIP PNLIPRP1 MYO5B RASA3 DNAH7 SMARCA1 MTR

4.28e-052311178gudmap_dev gonad_e11.5_M_GonMes_Sma_k4_1000
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_1000

CNTN4 MRC1 PNLIP MYO5B RASA3 CENPF ZNF618 DNAH7 ITGB5 IGF2R LTN1 SMARCA1 MTR PLEKHH2 ATP1B2

4.96e-0582711715gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_1000
CoexpressionAtlasdev gonad_e11.5_M_SupCellPrec_Sry_top-relative-expression-ranked_1000

PNLIP PNLIPRP1 MYO5B RASA3 DSP PRSS12 ZNF618 DNAH7 ITGB5 TBC1D4 NETO2 SMARCA1 MTR FBXO27 ATP1B2

5.68e-0583711715gudmap_dev gonad_e11.5_M_SupCellPrec_Sry_1000
CoexpressionAtlasdev gonad_e11.5_M_GonMes_Sma_top-relative-expression-ranked_1000

CNTN4 PNLIP PNLIPRP1 MYO5B RASA3 ZNF618 PFKFB3 DNAH7 ITGB5 NETO2 SMARCA1 MTR PLEKHH2 ATP1B2 SMAD3

6.66e-0584911715gudmap_dev gonad_e11.5_M_GonMes_Sma_1000
CoexpressionAtlasdev gonad_e12.5_F_SupCellPrec_Sry_k-means-cluster#1_top-relative-expression-ranked_1000

PNLIPRP1 MYO5B RASA3 ZNF618 DNAH7 TBC1D4 SMARCA1 KAT6B

9.54e-052591178gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_k1_1000
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_top-relative-expression-ranked_500

CNTN4 MRC1 MYO5B DDN NCF2 CPB2 ITGAL CD5L TBC1D4 SPON1

1.01e-0441511710gudmap_developingKidney_e15.5_Podocyte cells_500
CoexpressionAtlasdev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_1000

CNTN4 PNLIP PNLIPRP1 MYO5B RASA3 ZNF618 DNAH7 TBC1D4 SMARCA1 MTR PLEKHH2 ATP1B2 KAT6B SMAD3

1.26e-0479711714gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_1000
CoexpressionAtlasfacebase_RNAseq_e10.5_MaxArch_2500_K3

TUT4 CENPF ZNF618 CNTRL VEPH1 PGBD1 ZFP14 ITGB5 KIF20B FBXO30 PPP4R3A NSD3 PPP4R3B CCDC66 NETO2 SETD5 CDYL EPB41

1.68e-04125211718facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_top-relative-expression-ranked_1000

CNTN4 MRC1 MYO5B DSP DDN NCF2 CPB2 ITGAL CD5L TBC1D4 NETO2 SPON1 LY75 NOL8

2.07e-0483611714gudmap_developingKidney_e15.5_Podocyte cells_1000
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_top-relative-expression-ranked_200

CNTN4 MYO5B DDN CPB2 ITGAL SPON1

2.62e-041601176gudmap_developingKidney_e15.5_Podocyte cells_200
CoexpressionAtlasdev gonad_e11.5_F_GonMes_Sma_top-relative-expression-ranked_1000

CNTN4 PNLIP PNLIPRP1 MYO5B RASA3 ZNF618 PFKFB3 DNAH7 SMARCA1 MTR PLEKHH2 ATP1B2 KAT6B SMAD3

2.69e-0485811714gudmap_dev gonad_e11.5_F_GonMes_Sma_1000
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DRC7 C1orf87 TTC23L ODAD4 DNAH7 DNAH9 MAP3K19

6.51e-071811217dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

DRC7 C1orf87 TTC23L ODAD4 DNAH7 DNAH9 MAP3K19

7.54e-07185121718a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DRC7 C1orf87 TTC23L ODAD4 DNAH7 DNAH9 MAP3K19

8.11e-0718712179e10ed56090d82589bc457788282f664b70ace4b
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

DRC7 C1orf87 TTC23L ODAD4 DNAH7 DNAH9 MAP3K19

8.40e-07188121761a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

DRC7 PRSS12 C1orf87 TTC23L DNAH7 DNAH9 MAP3K19

8.40e-07188121734b11f72ca73153d02edcd09b38983ad1a504659
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

DRC7 PRSS12 C1orf87 TTC23L DNAH7 DNAH9 MAP3K19

8.71e-071891217a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DRC7 PRSS12 C1orf87 TTC23L DNAH7 DNAH9 MAP3K19

8.71e-07189121768a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

DRC7 C1orf87 TTC23L ODAD4 DNAH7 DNAH9 MAP3K19

8.71e-071891217b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

DRC7 PRSS12 C1orf87 TTC23L DNAH7 DNAH9 MAP3K19

8.71e-07189121727329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCelldroplet-Kidney-nan-3m-Epithelial-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSP EML2 PTCHD4 TBC1D4 SPON1 SMARCA1 PLEKHH2

9.67e-0719212178b625c22dda23c99654c82c529a1233e99e71b54
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

DRC7 C1orf87 ODAD4 DNAH7 SLC17A8 DNAH9 MAP3K19

1.07e-06195121760067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DRC7 C1orf87 ODAD4 DNAH7 SLC17A8 DNAH9 MAP3K19

1.27e-06200121796701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DRC7 PRSS12 C1orf87 TTC23L DNAH7 DNAH9 MAP3K19

1.27e-062001217926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DRC7 PRSS12 C1orf87 TTC23L DNAH7 DNAH9 MAP3K19

1.27e-06200121706ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FCRL2 SEMA4B TUT4 DSP PPP4R3A NSD3

5.05e-0616012167ad065337ac802de52c15ee715f6b78a3eed0cef
ToppCellCiliated_cells-B-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

DRC7 MYH3 PRSS12 DNAH7 ZNF799 DNAH9

6.24e-0616612164b1056aad8a99827835242b8ab0c7f2bb84471f1
ToppCelldroplet-Liver-Npc-18m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 PKD1L2 ITGAL ITGB5 LGALS3 CD5L

7.90e-0617312169ba55e21d1037ec3150d77895e52f0b051df65da
ToppCellCiliated_cells-A-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

PRSS12 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

8.71e-0617612161c364155f46b9a7c995bdc2cc2333c437cd90f5b
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DRC7 C1orf87 TTC23L DNAH7 DNAH9 MAP3K19

9.29e-061781216de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

DRC7 C1orf87 TTC23L ODAD4 DNAH7 DNAH9

1.05e-0518212167ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

DRC7 C1orf87 TTC23L DNAH7 DNAH9 MAP3K19

1.05e-051821216fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 NCF2 ITGAL LGALS3 CD5L LY75

1.12e-0518412168e5fc2bdd3071e782aa8c56b8a39f8ea8f03f623
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DRC7 C1orf87 TTC23L DNAH7 DNAH9 MAP3K19

1.12e-0518412165daff849625f2f41d56615569c0ed59cd733b34c
ToppCellCiliated_cells-B-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.16e-0518512164fc7113d3dadc716ec5a8e62b58543cc00ce5b16
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.16e-05185121630f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell390C-Epithelial_cells-Epithelial-F_(Ciliated)|390C / Donor, Lineage, Cell class and subclass (all cells)

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.19e-051861216708c5edefe36c91df27cf53c1b5101fb2030cc5a
ToppCell390C-Epithelial_cells-Epithelial-F_(Ciliated)-|390C / Donor, Lineage, Cell class and subclass (all cells)

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.19e-051861216029390c4aaf64e6bcd86124cd4a6dd2e6f3a374b
ToppCelltumor_Lung-Epithelial_cells-tS3|Epithelial_cells / Location, Cell class and cell subclass

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.23e-0518712163cea677279e71fdb9879530dea10a5e6393beacd
ToppCelltumor_Lung-Epithelial_cells-tS3|tumor_Lung / Location, Cell class and cell subclass

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.27e-05188121626326b4e298e33f9ba393fc632238aa8c54b1ea3
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____podocyte-2|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DSP VEPH1 EML2 TBC1D4 SPON1 SMARCA1

1.27e-051881216c300accbac71a3bc075fe985543d8a8ead82531b
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DRC7 C1orf87 TTC23L DNAH7 DNAH9 MAP3K19

1.27e-0518812162b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

VEPH1 MAGI3 CASR PFKFB3 TBC1D4 PLEKHH2

1.31e-051891216830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell356C-Epithelial_cells-Epithelial-F_(Ciliated)-|356C / Donor, Lineage, Cell class and subclass (all cells)

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.39e-0519112168a5a2188b13ef4bbfd626a42565566708a751c1b
ToppCell356C-Epithelial_cells-Epithelial-F_(Ciliated)|356C / Donor, Lineage, Cell class and subclass (all cells)

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.39e-051911216e314dd8f1a841cab847ae3703bedfe1bc623ac61
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DRC7 PRSS12 C1orf87 DNAH7 DNAH9 MAP3K19

1.39e-051911216e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DRC7 PRSS12 C1orf87 DNAH7 DNAH9 MAP3K19

1.39e-0519112169d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DRC7 PRSS12 C1orf87 DNAH7 DNAH9 MAP3K19

1.39e-0519112161c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellnormal_Lung-Epithelial_cells-Ciliated|normal_Lung / Location, Cell class and cell subclass

PRSS12 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.43e-051921216097a13121820ab4e5cd2365600efccf5ea4ce8c3
ToppCellIPF-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

DRC7 PRSS12 C1orf87 DNAH7 DNAH9 MAP3K19

1.43e-051921216d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCellASK452-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

PRSS12 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.47e-051931216c0d10075862ac878aa05fc49c8b73e470783bf16
ToppCellASK452-Epithelial-Ciliated|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

PRSS12 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.51e-0519412165aeb44657ab6f61b1abf98af28d3397d8e44c1aa
ToppCellwk_15-18-Epithelial-Proximal_epithelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.51e-051941216b0477583301dc6d9767b667bd2f8f94fbfaa6f81
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.56e-051951216cfcf554b436083179dea1d6fd6e3a800ea2430fe
ToppCell10x5'v1-week_14-16-Myeloid_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LRRC39 MRC1 ITGB5 LGALS3 CD5L TBC1D4

1.61e-051961216e0447ad2efb021b63c7fef000d39b6b21fbe6113
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.61e-051961216686a5a0ddb00929842c1c98445c59edfcc9a8a04
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.61e-05196121667aefc480714e4b8c9ae53c036efdc07ec6f94af
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.61e-051961216ca56311edc6788e032e7635fa69b1e07035202b5
ToppCellSevere_COVID-19-Epithelial-Ciliated|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.61e-0519612161cdef976a754c90d18b6149d367bd64e6e99b0a9
ToppCell10x5'v1-week_14-16-Myeloid_macrophage-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LRRC39 MRC1 ITGB5 LGALS3 CD5L TBC1D4

1.61e-0519612163bca88eede3dd7368715ced02e3bacd1e3e82cab
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.61e-05196121669f5081e06d84ec1d9695762df801a9d0df1984b
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Deuterosomal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

DRC7 CENPF PRSS12 ODAD4 DNAH7 DNAH9

1.65e-051971216861e8df9bd74dc5e17bafdc1fb3fef546753c73a
ToppCelldistal-Hematologic-Platelet/Megakaryocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DSP PRSS12 C1orf87 ODAD4 DNAH7 DNAH9

1.65e-051971216751ffb8792058384079ebfe94872b3525f1aea84
ToppCellCOVID-19-Epithelial|COVID-19 / Condition, Lineage and Cell class

DSP C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.65e-05197121618fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCelldistal-Epithelial-Ciliated-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PRSS12 C1orf87 ODAD4 DNAH7 SLC17A8 MAP3K19

1.70e-051981216d30d6c6a0a78b7571318b5b2a0186df96dd0f5a9
ToppCellLPS_IL1RA-Epithelial_alveolar|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MYO5B DSP VEPH1 LGALS3 FSD1L LMAN2

1.75e-0519912165b140ac88ebc25ce397ae577e48f3e271faf46e7
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

USP34 MAGI3 KCNMA1 TRAPPC9 VPS13B FBXW7

1.75e-05199121694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCelldistal-3-Epithelial-Ciliated|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.75e-0519912167e5f29f4ec1fea92f2c0064eea151d2d474ef904
ToppCellBiopsy_Control_(H.)-Epithelial-Ciliated|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

PRSS12 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-0520012169ae434c78e08adf95da49c85616e3ca72d1227bf
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-05200121652aef65f01b06cd98056f17977efe525aee6eb6f
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-05200121655c148238d5c80c1faa3428a917ae8075be2c145
ToppCellBiopsy_Other_PF-Epithelial-Differentiating_Ciliated|Biopsy_Other_PF / Sample group, Lineage and Cell type

PRSS12 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-052001216f7b4581d958afbd68f9045af619aaca0ab463439
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-05200121631d75c26055177d656df1fbb10b764cebd61e122
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-05200121685c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-052001216da12821e8a0657869ca0f75d351cce2d7605a505
ToppCellLPS_IL1RA-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-0520012164992dbf0514d674017315dbd20d91dfec0c608e9
ToppCell(09)_Interm._secr.>cil.|World / shred by cell type by condition

DRC7 CNTRL ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-0520012163305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-052001216e1dce91c6c531bb212002a14705e496d77ad3490
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-05200121612bc7d95c4166d12487081a76d210b7abe5991b0
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PRSS12 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-052001216ddd39b754bfaa98249d497dfb7e97ec58617a11a
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Ciliated|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

PRSS12 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-052001216a521cf837cadf280505ff9d7e641a205af7d6513
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PRSS12 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-052001216918b576fd9491d23c2bb9d663fa5fb3505cb1c7e
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 TRAPPC11 MRPL37 TTC4 KCNMA1 CCL7

1.80e-052001216f11ae9055e72c938b6c9e52701478b2eee681ac4
ToppCell10x5'v1-week_14-16-Myeloid_macrophage-stroma-stromal_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LRRC39 MRC1 PFKFB3 ITGB5 CD5L KCNMA1

1.80e-052001216af743dfef7e7cfaef1c494999757123f93a213e3
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DRC7 C1orf87 ODAD4 DNAH7 DNAH9 MAP3K19

1.80e-05200121672c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FCRL2 TUT4 DSP PPP4R3A NSD3

2.94e-051311215a3a086ce6e69707ca6a042f3b15c130f81909acb
ToppCelldroplet-Lung-nan-3m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF2 PKD1L2 ITGAL ZFYVE9 SLC17A8

4.47e-0514312154d11d53330a9197275a8851e1bbf55a113715a09
ToppCellMild/Remission-B_naive-1|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TUT4 PPP4R3A NSD3 PPP4R3B PLEKHH2

4.47e-051431215bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCelldroplet-Lung-nan-3m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCF2 PKD1L2 ITGAL ZFYVE9 SLC17A8

4.47e-0514312158b9f4d87d5faac7752c83e1992491fc5550600f8
ToppCellCiliated_cells-A-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

DRC7 C1orf87 DNAH7 DNAH9 MAP3K19

5.79e-0515112159d03ce73af15ef40c592d19b36aff46bebc14c40
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 ZNF618 MAGI3 TBC1D4 SACS

5.98e-051521215655d47efe0608d729801f1f01668e84c1bc0675f
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_Hsd17b2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PNLIPRP1 LGALS3 SLC17A8 ROS1

6.09e-05781214e5dbb0986cbee58fb1e5e464a3b003c4136246e7
ToppCell(2)_NK/T-(23)_CD4+_T_cell-(230)_CD4+/CD25+_Reg_T_cell|(23)_CD4+_T_cell / immune cells in Peripheral Blood (logTPM normalization)

MRC1 CNTRL CUL9 LGALS3 TBC1D4

6.36e-051541215059bdf6843f94f5028d4df6aa025865a9edb4521
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DRC7 ODAD4 DNAH7 DNAH9 MAP3K19

6.36e-0515412154e3bc24043144143842627cacf6f90dda2228910
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

LRRC39 CENPF PFKFB3 LGALS3 LZTS1

6.36e-051541215692eb053620db86d301b09bf743ab45fccc245be
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DRC7 ODAD4 DNAH7 DNAH9 MAP3K19

6.36e-0515412157556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DRC7 ODAD4 DNAH7 DNAH9 MAP3K19

6.55e-0515512155f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DRC7 ODAD4 DNAH7 DNAH9 MAP3K19

6.55e-0515512150944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellControl-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TUT4 DSP PPP4R3A NSD3 PPP4R3B

6.55e-0515512150a78d1cab2bdba2dc8a74cdf35b5a0192370c4b5
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

MRC1 ITGB5 CD5L SMARCA1 KCNMA1

6.76e-0515612159a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CNTN4 PTCHD4 KCNMA1 PLEKHH2 DNAH9

7.62e-051601215c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CNTN4 PTCHD4 KCNMA1 PLEKHH2 DNAH9

7.62e-05160121525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 ITGB5 CD5L ZFYVE9 CCL7

7.62e-0516012150544bc465af208da448858d6e174ff56f2e08a46
ToppCellPND01-03-samps-Myeloid-Macrophage-macrophage-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MRC1 NCF2 ITGAL LGALS3 LY75

7.84e-0516112155925ee646aa040550e3f8a164a13c8a5c0353319
ToppCellPND01-03-samps-Myeloid-Macrophage|PND01-03-samps / Age Group, Lineage, Cell class and subclass

MRC1 NCF2 ITGAL LGALS3 LY75

8.56e-05164121549733a9d3d95f05056b5b01916060ff20a8de3cf
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRSS12 MFSD6 ODAD4 LY75 DNAH9

8.56e-0516412159e16e52f5a634585f26021bcce9b5d5992ff6db0
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPF NCF2 ITGAL KIF20B LGALS3

8.81e-0516512151dcd6b8aa192baeaa1f7bb334843edab6049b96f
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FCRL2 TUT4 DSP PPP4R3A NSD3

8.81e-051651215fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCelldroplet-Fat-Scat-18m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 NCF2 LGALS3 CD5L CCL7

9.59e-051681215749eccebe4ee066f827d2a3980512f195f23ac27
ToppCellControl|World / group, cell type (main and fine annotations)

CNTN4 MYO5B VEPH1 MAGI3 ROS1

9.59e-051681215a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MRC1 NCF2 ITGAL LGALS3 FAN1

9.86e-051691215305cedbd97059029d7d2a248a8a4b6cfe281aa54
ComputationalNeighborhood of ZNF198

DMTF1 HECTD3 ZFP14 FBXO30 DFFA KAT6B SMAD2

1.49e-05117747GCM_ZNF198
ComputationalNeighborhood of MYST2

DMTF1 HECTD3 ZFP14 FBXO30 DFFA SETD5 KAT6B

1.74e-04172747GCM_MYST2
DrugHarmane hydrochloride [21655-84-5]; Up 200; 18.2uM; HL60; HT_HG-U133A

TUT4 PRSS12 MFSD6 KCNMA1 SENP6 CDYL KAT6B TRAPPC9 VPS13B FBXW7

9.98e-08198120102150_UP
DrugMefenamic acid [61-68-7]; Down 200; 16.6uM; MCF7; HT_HG-U133A

LZTS3 HIRA TBC1D4 SENP6 MACROH2A2 EXOC7 SMAD3 FBXW7

8.95e-0619412081699_DN
DrugQuinidine hydrochloride monohydrate [6151-40-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A

USP34 NSD3 HIRA TBC1D4 SENP6 KAT6B SMAD3 FBXW7

9.29e-0619512083191_DN
DrugCefamandole sodium salt [30034-03-8]; Down 200; 8.2uM; MCF7; HT_HG-U133A

CENPF CNTRL RBCK1 HIRA TBC1D4 CDYL TRAPPC9 SMAD3

1.00e-0519712083436_DN
Diseaseurate measurement, bone density

CNTN4 SPTLC3 ZNF618 MAGI3 SEC31A RBCK1 LZTS1 KCNMA1 SLC17A8 KAT6B DNAH9

3.14e-0561911511EFO_0003923, EFO_0004531
Diseasemicrocephaly (implicated_via_orthology)

AARS1 KIF20B EXOC7

2.63e-04321153DOID:10907 (implicated_via_orthology)
DiseaseLoeys-Dietz Syndrome

SMAD2 SMAD3

3.12e-0471152C2697932
Diseasevesicular integral-membrane protein VIP36 measurement

ITGB5 LMAN2

6.64e-04101152EFO_0022012
Diseasealopecia areata

MAGI3 PFKFB3 PLEKHH2

9.89e-04501153EFO_0004192
DiseaseObesity

MRC1 CPB2 PFKFB3 KCNMA1 VPS13B

1.27e-032051155C0028754
Diseasechromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)

HIRA PI4KA

1.33e-03141152DOID:0060413 (implicated_via_orthology)
DiseaseColorectal Carcinoma

CNTN4 ARFGEF1 EML2 FBXO30 SACS LZTS2 SMAD2 SMAD3 FBXW7

1.74e-037021159C0009402
Diseasecentral nervous system disease (implicated_via_orthology)

SEC31A SMARCA1

1.74e-03161152DOID:331 (implicated_via_orthology)
Diseasebreast carcinoma (is_marker_for)

IGF2R LZTS1 SMAD2

2.21e-03661153DOID:3459 (is_marker_for)
DiseaseMalignant Glioma

ROS1 ATP1B2 FBXW7

2.61e-03701153C0555198
Diseasemixed gliomas

ROS1 ATP1B2 FBXW7

2.61e-03701153C0259783
DiseaseLeft Ventricle Remodeling

SMAD2 SMAD3

3.01e-03211152C0600520
DiseaseVentricular Remodeling

SMAD2 SMAD3

3.01e-03211152C0600519

Protein segments in the cluster

PeptideGeneStartEntry
EQWKALNEIDAGVCE

PFKFB1

321

P16118
TAAEGDNWCEQKLKA

EPB41

41

P11171
SKEKEDLQEKCDIWE

CNTRL

1786

Q7Z7A1
DLQEKCDIWEKKLAQ

CNTRL

1791

Q7Z7A1
PKESKNTEVLVWEEC

ERVK-9

231

Q9UKH3
NGEKFTLEIWDKTCN

ARFGEF1

1511

Q9Y6D6
NGSCADIKKVEAWQV

CASR

446

P41180
WGSDKCEEQLEETIK

MACROH2A2

281

Q9P0M6
WDQVKALDNESEVKG

CNTN4

921

Q8IWV2
DNWGEKEDQVVCKQL

CD5L

271

O43866
EECGKVVETKQQLKW

CCDC144CP

551

Q8IYA2
NWDIKKTETVQEACE

DFFA

276

O00273
ELQDEESGSCLWVQK

DDN

16

O94850
CNTGKWTEEEEKRLA

DMTF1

271

Q9Y222
NPAVKNKAEECETWI

C1orf87

461

Q8N0U7
CEIDWNEGKNVTLKT

NAP1L2

331

Q9ULW6
NCVEAKDWIDILTKV

RASA3

661

Q14644
EKAGCDEIWEKICQV

PPP4R3A

86

Q6IN85
DEIWEKICQVQGKDP

PPP4R3A

91

Q6IN85
FKQAQELSWEKIECE

KAT6B

696

Q8WYB5
WKNNVDKRFEGVEDC

LTN1

1701

O94822
GDEENILLCEKDIWQ

PRSS12

241

P56730
LEETKWEVCQKSGEI

LZTS2

436

Q9BRK4
EETKWEVCQKAGEIS

LZTS3

436

O60299
ALEETQWEVCQKSGE

LZTS1

376

Q9Y250
DSQWCQGLQKGDIIK

MAGI3

606

Q5TCQ9
NWKEGDDAICLAELK

KCNMA1

541

Q12791
EDKNEWKNCIDITGV

LMAN2

231

Q12907
VLSKVNEEWLEGECK

NCF2

486

P19878
DKGEENWLANVCKNL

PNLIP

96

P16233
KDERCWEIIDNIKGT

FSD1L

246

Q9BXM9
QIVVQKKDGCDWIRC

RBCK1

451

Q9BYM8
EKKSCGQVVEEWKEF

ATP1B2

6

P14415
IVCNTKLDNNWGREE

LGALS3

171

P17931
VCTGAVNAVKEVWEK

LRRC39

6

Q96DD0
EEVNCICVDWKKGSQ

PNLIPRP1

116

P54315
EQWKALNEIDAGVCE

PFKFB3

316

Q16875
EKTWRELKGCPQEDV

FAM74A3

101

Q4VXF1
ATELEKWKEKCNDLE

KIF20B

1406

Q96Q89
AKDEKNAEEWLQCIN

VEPH1

801

Q14D04
VWAVKDEQGAENLCI

PI4KA

446

P42356
KPENGCEDNWEKNEQ

LY75

211

O60449
LGELGQWKVQSCEEK

LY75

466

O60449
WNEDCGKEKPEEIQD

NOL8

1016

Q76FK4
EKAGCDEIWEKICQV

PPP4R3B

86

Q5MIZ7
DEIWEKICQVQGKDP

PPP4R3B

91

Q5MIZ7
EEEIDWIEKHCVKIN

MFSD6

51

Q6ZSS7
CNEGVKNLAWVDSDQ

MRPL37

366

Q9BZE1
DAVLQAAVCKEKIGW

ITGB5

251

P18084
ICDIISKWEQASKEQ

PLEKHH2

1186

Q8IVE3
DGLEELCKIQKAWAI

EXOC7

661

Q9UPT5
DLEQGCSWANVKEEV

PKD1L2

201

Q7Z442
EKTWRELKGCPQEDV

FAM74A7

101

A6NL05
QNEAICAGKTDILWK

CCDC150

81

Q8NCX0
KEQAAKNAIWIDCGI

CPB2

166

Q96IY4
DIGDNVAKVNDSWKE

CENPF

1881

P49454
ANERECEVLKKIWGS

CDYL

566

Q9Y232
PKESKNTEVLVWEEC

ERVK-24

121

P61566
PKESKNTEVLVWEEC

ERVK-7

121

P61567
KALDDKNCWEKLGEV

COPA

666

P53621
KNEWKGRTVALCEND

DIS3L

301

Q8TF46
RQCEKENLGWQKLES

DSP

1146

P15924
EKAVKEGTWVVLQNC

DNAH7

3476

Q8WXX0
EDNLLWREKCKEEGI

FBXW7

316

Q969H0
GKNVKLVERLVEWCE

RAP1GDS1

441

P52306
CEQKIAIENEWKPAD

CCDC66

231

A2RUB6
GEKLTCWQAVRLKDE

DRC7

761

Q8IY82
PKESKNTEVLVWEEC

ERVK-21

231

P61565
PKESKNTEVLVWEEC

ERVK-5

121

Q9HDB8
LCQGSSVEVKEDKCW

CUL9

1156

Q8IWT3
SVEVKEDKCWEKVEV

CUL9

1161

Q8IWT3
DWAKETKVVDVKCSN

EML2

191

O95834
RKEVCQLKELWDTIG

DNAH9

1296

Q9NYC9
DKEICADPTQKWVQD

CCL7

71

P80098
GDSIVLKCQGEQNWK

FCRL2

31

Q96LA5
LKCNREGKEWETVLT

HIRA

721

P54198
EECGKVVETKQQLKW

CCDC144A

731

A2RUR9
CWKKVDLGDVKNVDV

FBXO30

366

Q8TB52
CCKKQVLDLEEEGLW

FBXO27

161

Q8NI29
ACKNLGWQIDDSVQD

FBXW2

101

Q9UKT8
ESGQCWNLKDDSKEI

SACS

226

Q9NZJ4
CLEKEENWKSKEIEE

MAP3K19

301

Q56UN5
ENWKSKEIEECNKIE

MAP3K19

306

Q56UN5
EEAVKKTNKCVLVWE

PRPF3

621

O43395
EFQKWECKNDTLLGI

MRC1

96

P22897
NGNWEEAKELAQCAK

FAN1

621

Q9Y2M0
GCEAETQTEELKNWK

IGF2R

986

P11717
GCDNLIKLWKEEEDG

SEC13

186

P55735
EECEGNVTWKIKLRN

TAS2R20

156

P59543
SAEDLCTKECGWVQK

SPON1

331

Q9HCB6
CTKECGWVQKVVQDL

SPON1

336

Q9HCB6
WFDTKNCLGDQKLVE

SMARCA1

371

P28370
WICGLKLQESEEKEV

NBPF7P

301

P0C2Y1
EKSQQCAEEEGDIEW

ODAD4

421

Q96NG3
TQDLIGEKWENEFCK

PTCHD4

186

Q6ZW05
CEDLIWNKDPEATEK

MTR

631

Q99707
QELLWGADAEKKQQC

SEMA4B

106

Q9NPR2
EWLNDKAEKQECPVE

SETD5

706

Q9C0A6
DKVLAEWKTKCEESQ

MYH3

1451

P11055
EWKTKCEESQAELEA

MYH3

1456

P11055
EEKTKPGQAVDCIWT

NETO2

196

Q8NC67
WGIEKCNAAVERKEQ

SPTLC3

86

Q9NUV7
ETWEIPFEKNCGEDK

ITGAL

761

P20701
LVKVKEEDPTWEQVC

PGBD1

16

Q96JS3
DKVECANNALKADWE

SNX7

321

Q9UNH6
AWKEINDGKECTLFE

B3GALT9

321

A8MXE2
ICGLGKIDVNDWKVN

SMURF2

626

Q9HAU4
PSKETCENRLDWKEQ

SPG11

1861

Q96JI7
IGKVCELINEVKESW

ZNF618

826

Q5T7W0
DEPQWKEKQSECATR

TRAPPC11

106

Q7Z392
ECKQIWQNLGLDDTK

AARS1

151

P49588
GEQNGQEEKWCEKAV

SMAD2

31

Q15796
GEQNGQEEKWCEKAV

SMAD3

21

P84022
DCVGMKWKDQNIEDQ

ZNF799

41

Q96GE5
EDKVWNDCKGVNKLT

SENP6

526

Q9GZR1
KNSIQWEKAEDNGCR

ROS1

1766

P08922
EEFCKWLVQNGEKQD

TTC23L

346

Q6PF05
EVGACQKEVLITWDK

TBC1D4

881

O60343
KIKCKWESQDHGEEV

NSD3

1421

Q9BZ95
KELSSCKIWEEVAGE

ZNF229

101

Q9UJW7
EVGNKTEWEVGICKD

TRIML1

346

Q8N9V2
QKVKSKEVLCWEQEG

VPS13B

416

Q7Z7G8
WDEADVKLQQCRVAK

ZZEF1

661

O43149
NKKIDFQWVQGDVCE

TRAPPC9

586

Q96Q05
NDWECKSKIEGEKEQ

ZFP14

121

Q9HCL3
CKKGNTLLWDIVQDE

USP34

856

Q70CQ2
GNVEKLVACWTKAQD

SEC31A

696

O94979
GIVEEKFVKWECNSS

TUT4

561

Q5TAX3
VNWCDEGLQIDAKEK

TTC4

171

O95801
SWDDQCSAVEVGEKK

ZFYVE9

121

O95405
ELWQDAEQIKRCQEK

ZNF81

131

P51508
KQEWADPENLSEEKC

SLC17A8

506

Q8NDX2
VCLGKKWEDQDIEDD

ZNF14

41

P17017
WQELEKKVCGDPEVT

HECTD3

736

Q5T447
DEECKVPKGTDQNWA

MYO5B

511

Q9ULV0