Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ethanolamine kinase activity	ETNK1 CHKA CHKB	7.89e-08	4	55	3	GO:0004305
GeneOntologyMolecularFunction	heparan sulfate 6-O-sulfotransferase activity	HS6ST2 HS6ST1	2.23e-05	3	55	2	GO:0017095
GeneOntologyMolecularFunction	choline kinase activity	CHKA CHKB	2.23e-05	3	55	2	GO:0004103
GeneOntologyBiologicalProcess	phosphatidylethanolamine biosynthetic process	ETNK1 CHKA CHKB	2.01e-06	10	54	3	GO:0006646
GeneOntologyBiologicalProcess	carbohydrate derivative metabolic process	SLC9A1 PIGT PGAP3 TM9SF2 TMTC4 ICMT HS6ST2 HS6ST1 DGUOK G6PC2 PLOD1 PDHX	6.16e-05	1226	54	12	GO:1901135
GeneOntologyBiologicalProcess	phosphatidylethanolamine metabolic process	ETNK1 CHKA CHKB	6.55e-05	30	54	3	GO:0046337
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process	TM9SF2 HS6ST2 HS6ST1	1.05e-04	35	54	3	GO:0015012
GeneOntologyBiologicalProcess	carbohydrate derivative biosynthetic process	PIGT PGAP3 TM9SF2 TMTC4 HS6ST2 HS6ST1 DGUOK PLOD1 PDHX	1.13e-04	736	54	9	GO:1901137
GeneOntologyBiologicalProcess	regulation of intracellular protein transport	GCC2 SLC35D3 BAG3 EIF3E EI24	1.13e-04	182	54	5	GO:0033157
GeneOntologyBiologicalProcess	CDP-choline pathway	CHKA CHKB	1.40e-04	7	54	2	GO:0006657
GeneOntologyBiologicalProcess	regulation of intracellular transport	GCC2 SLC35D3 BAG3 EIF3E EI24 TBC1D20	1.66e-04	314	54	6	GO:0032386
GeneOntologyBiologicalProcess	glycerophospholipid biosynthetic process	PIGT PGAP3 ETNK1 CHKA CHKB	2.56e-04	217	54	5	GO:0046474
GeneOntologyCellularComponent	endoplasmic reticulum membrane	PIGT PGAP3 ICMT SLC35D3 EI24 FAXDC2 G6PC2 MBOAT4 PLOD1 PTGS1 TBC1D20 ITPR2	9.04e-05	1293	54	12	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	PIGT PGAP3 ICMT SLC35D3 EI24 FAXDC2 G6PC2 MBOAT4 PLOD1 PTGS1 TBC1D20 ITPR2	9.45e-05	1299	54	12	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	PIGT PGAP3 ICMT SLC35D3 EI24 FAXDC2 G6PC2 MBOAT4 PLOD1 PTGS1 TBC1D20 ITPR2	1.16e-04	1327	54	12	GO:0042175
Domain	Heparan_SO4-6-sulfoTrfase	HS6ST2 HS6ST1	2.64e-05	3	56	2	IPR010635
Domain	EMP70	TM9SF2 TM9SF1	5.28e-05	4	56	2	IPR004240
Domain	EMP70	TM9SF2 TM9SF1	5.28e-05	4	56	2	PF02990
Domain	Sulfotransfer_2	HS6ST2 HS6ST1	5.72e-04	12	56	2	PF03567
Domain	Sulfotransferase	HS6ST2 HS6ST1	5.72e-04	12	56	2	IPR005331
Domain	Ldl_recept_b	LRP1 LRP5L	7.85e-04	14	56	2	PF00058
Domain	LDLRB	LRP1 LRP5L	7.85e-04	14	56	2	PS51120
Domain	LY	LRP1 LRP5L	9.04e-04	15	56	2	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP5L	9.04e-04	15	56	2	IPR000033
Domain	Nucleotide-diphossugar_trans	B3GNTL1 GYG2 PLOD1	2.34e-03	88	56	3	IPR029044
Domain	TAS2R	TAS2R7 TAS2R40	2.74e-03	26	56	2	PF05296
Domain	T2R	TAS2R7 TAS2R40	2.74e-03	26	56	2	IPR007960
Pathway	REACTOME_SYNTHESIS_OF_PE	ETNK1 CHKA CHKB	6.12e-06	12	44	3	MM14586
Pathway	REACTOME_SYNTHESIS_OF_PE	ETNK1 CHKA CHKB	7.94e-06	13	44	3	M656
Pathway	WP_KENNEDY_PATHWAY_FROM_SPHINGOLIPIDS	ETNK1 CHKA CHKB	1.01e-05	14	44	3	M39620
Pathway	WP_KENNEDY_PATHWAY	ETNK1 CHKA CHKB	1.01e-05	14	44	3	MM15980
Pubmed	Deletion and alanine mutation analyses for the formation of active homo- or hetero-dimer complexes of mouse choline kinase-alpha and -beta.	CHKA CHKB	2.55e-06	2	56	2	16490392
Pubmed	Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse.	CHKA CHKB	2.55e-06	2	56	2	20026284
Pubmed	Expression and characterization of the active molecular forms of choline/ethanolamine kinase-alpha and -beta in mouse tissues, including carbon tetrachloride-induced liver.	CHKA CHKB	2.55e-06	2	56	2	11964179
Pubmed	Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.	CHKA CHKB	2.55e-06	2	56	2	19915674
Pubmed	Structure and function of choline kinase isoforms in mammalian cells.	CHKA CHKB	2.55e-06	2	56	2	15003397
Pubmed	Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling.	HS6ST2 HS6ST1	2.55e-06	2	56	2	24563483
Pubmed	Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.	HS6ST2 HS6ST1	2.55e-06	2	56	2	12492399
Pubmed	Molecular cloning of mouse choline kinase and choline/ethanolamine kinase: their sequence comparison to the respective rat homologs.	CHKA CHKB	2.55e-06	2	56	2	9714798
Pubmed	Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.	CHKA CHKB	2.55e-06	2	56	2	20299452
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	PIGT QPCTL TM9SF2 GTF3C1 HS6ST2 TM9SF1 EI24 LRP1 PLOD1 PTGS1 ITPR2	2.85e-06	1201	56	11	35696571
Pubmed	The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.	HS6ST2 HS6ST1	7.63e-06	3	56	2	10644753
Pubmed	Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis.	HS6ST2 HS6ST1	7.63e-06	3	56	2	15499561
Pubmed	Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory effects of heparin on the activities of various proteases in mast cells and the biosynthesis of 6-O-sulfated heparin.	HS6ST2 HS6ST1	7.63e-06	3	56	2	23223449
Pubmed	Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases.	HS6ST2 HS6ST1	7.63e-06	3	56	2	12611590
Pubmed	Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury.	SLC9A1 RPS6KA2	7.63e-06	3	56	2	16717153
Pubmed	Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta.	CHKA CHKB	7.63e-06	3	56	2	10706593
Pubmed	Overexpression of heparan sulfate 6-O-sulfotransferases in human embryonic kidney 293 cells results in increased N-acetylglucosaminyl 6-O-sulfation.	HS6ST2 HS6ST1	7.63e-06	3	56	2	16326709
Pubmed	Proteoglycans and their roles in brain cancer.	HS6ST2 HS6ST1	1.52e-05	4	56	2	23281850
Pubmed	Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation.	HS6ST2 HS6ST1	1.52e-05	4	56	2	29104277
Pubmed	Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity.	HS6ST2 HS6ST1	1.52e-05	4	56	2	15226404
Pubmed	Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.	HS6ST2 HS6ST1	1.52e-05	4	56	2	23074159
Pubmed	Analysis of axon guidance defects at the optic chiasm in heparan sulphate sulphotransferase compound mutant mice.	HS6ST2 HS6ST1	1.52e-05	4	56	2	21951307
Pubmed	6-O-sulfation of heparan sulfate differentially regulates various fibroblast growth factor-dependent signalings in culture.	HS6ST2 HS6ST1	2.54e-05	5	56	2	18281280
Pubmed	A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis.	CHKA CHKB	2.54e-05	5	56	2	16371353
Pubmed	2- and 6-O-sulfated proteoglycans have distinct and complementary roles in cranial axon guidance and motor neuron migration.	HS6ST2 HS6ST1	2.54e-05	5	56	2	27048738
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	PIGT TM9SF2 HS6ST2 GCC2 TM9SF1 BAG3 EIF3E PLOD1	2.67e-05	754	56	8	33060197
Pubmed	Sulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression in the urogenital sinus.	HS6ST2 HS6ST1	5.32e-05	7	56	2	20410206
Pubmed	Comparative analysis of the expression patterns of TM9SF family members in mice.	TM9SF2 TM9SF1	5.32e-05	7	56	2	38719197
Pubmed	Chondroitin sulfate enhances the barrier function of basement membrane assembled by heparan sulfate.	HS6ST2 HS6ST1	5.32e-05	7	56	2	35608020
Pubmed	Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality.	HS6ST2 HS6ST1	7.09e-05	8	56	2	17405882
Pubmed	Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate.	HS6ST2 HS6ST1	9.10e-05	9	56	2	21357686
Pubmed	A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships.	HS6ST2 HS6ST1	9.10e-05	9	56	2	30377379
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	ZSWIM8 TM9SF2 TM9SF1 BAG3 PLOD1	9.21e-05	282	56	5	35007762
Pubmed	Defining the membrane proteome of NK cells.	PIGT QPCTL GTF3C1 EML4 GCC2 EIF3E EI24 ETNK1 ITPR2	9.65e-05	1168	56	9	19946888
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	TMEM144 TM9SF2 HS6ST1 EI24 GDPD2 CCR6 TBC1D20	1.25e-04	697	56	7	28298427
Pubmed	Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.	HS6ST2 HS6ST1	1.39e-04	11	56	2	15944372
Pubmed	Involvement of heparan sulfate 6-O-sulfation in the regulation of energy metabolism and the alteration of thyroid hormone levels in male mice.	HS6ST2 HS6ST1	1.39e-04	11	56	2	23690091
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	PIGT QPCTL TM9SF2 ICMT TM9SF1 EI24	1.50e-04	499	56	6	22810586
Pubmed	Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.	HS6ST2 HS6ST1	1.66e-04	12	56	2	12460940
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ZNF775 PGAP3 GTF3C1 PKHD1 ARHGAP20 PTGS1 ITPR2	1.74e-04	736	56	7	29676528
Pubmed	Assignment of the mouse homologues of 6 loci from HSA1p to chromosomes 3 and 4.	SLC9A1 PLOD1	1.96e-04	13	56	2	7829080
Pubmed	Efficient and fast targeted production of murine models based on ENU mutagenesis.	KCNK18 QPCTL	2.64e-04	15	56	2	16075367
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	SLC9A1 PIGT TM9SF2 TMTC4 EML4 TM9SF1 BAG3 PDHX	2.83e-04	1061	56	8	33845483
Pubmed	FGF signaling activates a Sox9-Sox10 pathway for the formation and branching morphogenesis of mouse ocular glands.	HS6ST2 HS6ST1	3.83e-04	18	56	2	24924191
Pubmed	Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis.	HS6ST2 HS6ST1	4.75e-04	20	56	2	24753163
Pubmed	Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development.	HS6ST2 HS6ST1	4.75e-04	20	56	2	22745308
Pubmed	Evolutionary relationships of the Tas2r receptor gene families in mouse and human.	TAS2R7 TAS2R40	5.76e-04	22	56	2	12734386
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TMEM144 B3GNTL1 GTF3C1 MORN1 ZNF875 GCC2 RPS6KA2 LRP1 PLOD1	5.81e-04	1489	56	9	28611215
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	GTF3C1 EML4 RPS6KA2 EIF3E PLOD1 LYST ITPR2	6.24e-04	910	56	7	36736316
Pubmed	The molecular receptive ranges of human TAS2R bitter taste receptors.	TAS2R7 TAS2R40	6.30e-04	23	56	2	20022913
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	PIGT QPCTL ICMT EIF3E EI24 LRP1 PLOD1 TBC1D20	6.51e-04	1203	56	8	29180619
Pubmed	Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.	HS6ST2 HS6ST1	6.87e-04	24	56	2	34653670
Pubmed	Receptors for bitter and sweet taste.	TAS2R7 TAS2R40	7.46e-04	25	56	2	12139982
Pubmed	Molecular mechanisms of bitter and sweet taste transduction.	TAS2R7 TAS2R40	8.07e-04	26	56	2	11696554
Pubmed	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	TAS2R7 TAS2R40	8.71e-04	27	56	2	12581520
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	PIGT GTF3C1 EIF3E EI24 PLOD1	8.86e-04	462	56	5	31138677
Pubmed	Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.	TAS2R7 TAS2R40	9.37e-04	28	56	2	15744053
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	SLC9A1 PIGT EI24 TBC1D20 ITPR2	9.38e-04	468	56	5	31056421
Pubmed	Adaptive diversification of bitter taste receptor genes in Mammalian evolution.	TAS2R7 TAS2R40	1.08e-03	30	56	2	12679530
Pubmed	Liver and brain differential expression of one-carbon metabolism genes during ontogenesis.	CHKA CHKB	1.30e-03	33	56	2	34702858
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	PIGT HS6ST2 EI24 ITPR2	1.33e-03	296	56	4	34186245
Pubmed	Evolution of bitter taste receptors in humans and apes.	TAS2R7 TAS2R40	1.38e-03	34	56	2	15496549
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	GCC2 EIF3E ITPR2	1.48e-03	139	56	3	25476789
Pubmed	Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies.	TM9SF2 HS6ST2	1.55e-03	36	56	2	33263384
Pubmed	Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.	SLC22A6 PKHD1	1.55e-03	36	56	2	33737325
Cytoband	13q32.3	TM9SF2 TMTC4	3.64e-04	23	56	2	13q32.3
Cytoband	6q27	RPS6KA2 CCR6	2.08e-03	55	56	2	6q27
Cytoband	Ensembl 112 genes in cytogenetic band chr6q27	RPS6KA2 CCR6	4.34e-03	80	56	2	chr6q27
GeneFamily	Transmembrane 9 superfamily members	TM9SF2 TM9SF1	2.05e-05	4	34	2	1239
GeneFamily	Sulfotransferases, membrane bound	HS6ST2 HS6ST1	2.19e-03	37	34	2	763
GeneFamily	Taste 2 receptors	TAS2R7 TAS2R40	2.44e-03	39	34	2	1162
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_DN	ZSWIM8 TM9SF2 TM9SF1 LRP1 CHKA PLOD1 PTGS1	5.19e-05	457	56	7	M1613
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_DN	ZSWIM8 TM9SF2 TM9SF1 LRP1 CHKA PLOD1 PTGS1	6.19e-05	470	56	7	MM1053
Coexpression	GSE19374_UNINF_VS_LISTERIA_INFECTED_MACROPHAGE_DN	ZSWIM8 SLC9A1 LRRTM2 CCR6 PLOD1	6.53e-05	198	56	5	M7265
Coexpression	GSE22886_IGG_IGA_MEMORY_BCELL_VS_BLOOD_PLASMA_CELL_DN	TM9SF1 BAG3 ETNK1 PLOD1 PDHX	6.53e-05	198	56	5	M4446
Coexpression	GSE27786_LIN_NEG_VS_NKTCELL_DN	ZSWIM8 PIGT EI24 ETNK1 CHKB	6.85e-05	200	56	5	M4788
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000	HS6ST2 GCC2 HS6ST1 RPS6KA2 BAG3 EI24 CHKA CHKB ARHGAP20 ITPR2	2.22e-05	791	53	10	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_1000
CoexpressionAtlas	dev gonad_e12.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000	HS6ST2 GCC2 HS6ST1 RPS6KA2 BAG3 GDPD2 CHKA CHKB ARHGAP20 ITPR2	2.52e-05	803	53	10	gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_1000
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_500	HS6ST2 GCC2 HS6ST1 RPS6KA2 BAG3 CHKA ARHGAP20	6.21e-05	404	53	7	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_500
CoexpressionAtlas	dev gonad_e12.5_F_SupCellPrec_Sry_top-relative-expression-ranked_500	HS6ST2 GCC2 HS6ST1 BAG3 GDPD2 ARHGAP20 ITPR2	7.24e-05	414	53	7	gudmap_dev gonad_e12.5_F_SupCellPrec_Sry_500
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM151A RPS6KA2 SLC35D3 GDPD2 G6PC2	2.66e-06	174	56	5	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM151A RPS6KA2 SLC35D3 GDPD2 G6PC2	2.97e-06	178	56	5	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA2 CALCRL LYST PTGS1 ITPR2	3.68e-06	186	56	5	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	facs-Heart-RA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA2 SLC35D3 CALCRL PTGS1 ITPR2	3.88e-06	188	56	5	4ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCell	facs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA2 SLC35D3 CALCRL PTGS1 ITPR2	3.88e-06	188	56	5	e47e66906922d5c69b1aafe28face0787d3fc563
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS6KA2 ETNK1 LYST PTGS1 ITPR2	3.98e-06	189	56	5	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	EML4 GCC2 EIF3E FAXDC2 ITPR2	4.41e-06	193	56	5	e6a688bc834f845ff64dae1be64f073eec5091a1
Drug	octylglucopyranoside	SLC9A1 TM9SF1 DGUOK CHKB PLOD1 PTGS1	2.96e-06	163	56	6	CID000062080
Drug	phlorobenzophenone	ICMT LYST	5.94e-06	2	56	2	CID000077093
Drug	moracin M	ICMT PTGS1	1.78e-05	3	56	2	CID000185848
Drug	AC1NSUKT	ICMT PTGS1	1.78e-05	3	56	2	CID005316726
Disease	epilepsy (implicated_via_orthology)	KCNK18 LRP1 ETNK1 CHKA CHKB	1.23e-05	163	54	5	DOID:1826 (implicated_via_orthology)
Disease	microcephaly (implicated_via_orthology)	ETNK1 CHKA CHKB	2.77e-05	32	54	3	DOID:10907 (implicated_via_orthology)
Disease	heart conduction disease (implicated_via_orthology)	KCNK18 ETNK1	1.57e-03	32	54	2	DOID:10273 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
YAAWLSRGSSTWLTA	C4B	1066	P0C0L5
NFTLKQSSFVGWWTH	ADAM20	191	O43506
QSSFVGWWTHQRFVE	ADAM20	196	O43506
FWAVSHATGAWVFSN	CCR6	101	P51684
DWHSFLLWEFASRIT	DGUOK	171	Q16854
ALASHFFWGLWSILQ	CHKB	346	Q9Y259
TSHASRLWQTLQQFW	CBY3	66	A6NI87
SAFYTIWSGWHRRTE	QPCTL	46	Q9NXS2
NPALFWFSRHISLWG	ITPR2	2216	Q14571
WFSRHISLWGSISFN	ITPR2	2221	Q14571
LNSHSHARGWSWAIF	LILRA2	166	Q8N149
RRHWAWSGDTFSGQF	MORN1	76	Q5T089
KPQWFNRTTHWSFLS	KCNK18	91	Q7Z418
ALASWLGSFQGRWEH	LRRTM2	321	O43300
HGLAVDWVSRNLFWT	LRP1	1661	Q07954
SVSRGANWRWFHSTQ	PDHX	36	O00330
VNWVARSLYWTHTGT	LRP5L	41	A4QPB2
FSWTELKRLNAGSWF	GDPD2	296	Q9HCC8
SFTHFLLTHGRWFWE	PTGS1	86	P23219
LLTHGRWFWEFVNAT	PTGS1	91	P23219
WLFSRFSTGWSCGLH	HS6ST1	136	O60243
HGRLWSNFWGALSAD	PLOD1	411	Q02809
SSSQHQAAFLHLWWT	GYG2	271	O15488
LSFVAFWNSVTWHLQ	FAXDC2	36	Q96IV6
TLLSFSQSSWSHFGW	ICMT	81	O60725
VRAAWPHFSWLLSQS	FAM151A	251	Q8WW52
RFALASHFLWGLWSI	CHKA	411	P35790
SWLEFFLTSIFSALW	EI24	116	O14681
WSPFHADIFRSFSWS	JMJD4	231	Q9H9V9
NASRSSGWASYLHSW	GCC2	1666	Q8IWJ2
RTWLIHWSLFVFFNH	EIF3E	211	P60228
FSITLHRLTWSFLWS	G6PC2	141	Q9NQR9
WPHLSEGFSVSLWFN	LYST	1466	Q99698
PLLQTFAFSAWWHGL	MBOAT4	326	Q96T53
WLFSRFSTGWSCGLH	HS6ST2	276	Q96MM7
SHIFFWTWSGNSLTR	EML4	431	Q9HC35
QFALASHFFWGLWAL	ETNK1	401	Q9HBU6
WPFFVDHNSRTTTWN	BAG3	36	O95817
WFFIESARWHSSSGR	SLC22A6	266	Q4U2R8
WFRHPASNRTWTNYT	CALCRL	111	Q16602
SLNAWFWSTVFHTRD	PGAP3	146	Q96FM1
GTLITALSSHWFFTW	MT-ND2	16	P03891
NWAFWRGSSTHLDNL	ARHGAP20	336	Q9P2F6
TVFLNHSNLWFAAWL	TAS2R40	101	P59535
FASTDSIHAWTFPGW	SLC35D3	206	Q5M8T2
SLQFCRRWSRTHSWF	PKHD1	1921	P08F94
TWFCSRAWFSHVGPF	B3GNTL1	181	Q67FW5
DFFWTLTNHLSIWFA	TAS2R7	86	Q9NYW3
WHHDFWGSRLSSNTS	TMTC4	66	Q5T4D3
HLSFTQGFWRTRYWG	PIGT	86	Q969N2
LIWGSFNALTGWASS	TMEM144	96	Q7Z5S9
FSWWSSLKIHQRTHT	ZNF775	116	Q96BV0
SHHWNWTFVISTLLF	SLC9A1	406	P19634
QITGWWYSVRTSASH	ZSWIM8	381	A7E2V4
YHWQWRSFLTSGFTA	TM9SF2	586	Q99805
FALSWLITWFGHVLS	TBC1D20	216	Q96BZ9
WLSHLSQLFSSLWAG	ZNF875	131	P10072
SSFYGHLKRNWIWTS	GTF3C1	1121	Q12789
PFFLTWSVVNSVHWA	TM9SF1	386	O15321
VNRRGHTQSADWWSF	RPS6KA2	231	Q15349