Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	FYVE_2	RPH3AL RPH3A RIMS1	7.08e-05	11	144	3	PF02318
Domain	RABBD	RPH3AL RPH3A RIMS1	9.38e-05	12	144	3	PS50916
Domain	Rab_BD	RPH3AL RPH3A RIMS1	9.38e-05	12	144	3	IPR010911
Domain	MAP1	MAP1A MAP1S	1.76e-04	3	144	2	IPR026074
Domain	FAM117	FAM117B FAM117A	1.76e-04	3	144	2	PF15388
Domain	Glcci1/FAM117	FAM117B FAM117A	1.76e-04	3	144	2	IPR026642
Domain	FAM47	FAM47A FAM47C	3.51e-04	4	144	2	PF14642
Domain	FAM47	FAM47A FAM47C	3.51e-04	4	144	2	IPR032743
Domain	-	MAP1A MBLAC1 MAP1S	4.65e-04	20	144	3	3.60.15.10
Domain	Metallo-B-lactamas	MAP1A MBLAC1 MAP1S	4.65e-04	20	144	3	IPR001279
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PITPNM2 ZNF48 KIF26A POLE NLRX1 OBSCN FBRSL1 C15orf39 CNTROB TFE3 ANO8 KANSL3 PRR12 ZNF263 SH3PXD2B INTS5 MAP1S ANKRD34A LRRC56 IRS2 SPEN PRRT4 ELL TBCD WDR24	4.49e-11	1105	159	25	35748872
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PRUNE2 PITPNM2 CDS1 LMF1 MIA3 RPH3AL SCAF8 OBSCN FBRSL1 FAM117B BRWD3 DNAH14 ANO8 SBK1 KANSL3 PTPRN2 SH3PXD2A TBC1D1 RPRD2 RIMS1 MAP2K2 TBCD	1.28e-06	1489	159	22	28611215
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	MAP1A SYNM SCAF8 ANKLE2 CNTROB PRR12 RPRD2 SPEN	2.26e-06	184	159	8	32908313
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PRUNE2 PRRG2 MAP1A DISC1 APC2 LMTK3 ZNF469 MAP1S RNF38 SPEN SOS1	5.10e-06	430	159	11	35044719
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PITPNM2 KIF26A RNF44 FBRSL1 ANKLE2 MYEF2 KANSL3 INTS5 ZC3H4 RPRD2 KCNT1 ZNF646	6.39e-06	529	159	12	14621295
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	CYP46A1 SBK1 SNIP1 MAP1S SLTM IRS2 SNRNP70 SPEN PRRC2A WDR24	6.96e-06	361	159	10	26167880
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PRUNE2 SYNM ARHGEF17 PTPRN2 RIMS1 ZNF646	8.71e-06	104	159	6	9205841
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MIA3 CAD APC2 SIPA1 LMTK3 PLA2G15 RPH3A SHANK3 MYEF2 ZNF263 SH3PXD2B PTPRN2 ZC3H4 RIMS1 PRRC2A KCNT1	9.61e-06	963	159	16	28671696
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SCAF8 KANSL3 QSOX1 TBC1D10B INTS5 MAP1S PRICKLE3 ZC3H4 IRS2 RIMS1 MAP2K2 SPEN PRRC2A SOS1	1.40e-05	774	159	14	15302935
Pubmed	Clinical significance of a novel single nucleotide polymorphism in the 5' untranslated region of the Rabphillin-3A-Like gene in colorectal adenocarcinoma.	RPH3AL RPH3A	2.08e-05	2	159	2	17981610
Pubmed	MKRN3 and KISS1R mutations in precocious and early puberty.	MKRN3 KISS1R	2.08e-05	2	159	2	32228714
Pubmed	Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.	IPO8 TFE3	2.08e-05	2	159	2	26168401
Pubmed	Isoform-selective interaction of the adaptor protein Tks5/FISH with Sos1 and dynamins.	SH3PXD2A SOS1	2.08e-05	2	159	2	19464300
Pubmed	Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth.	TAOK3 SH3PXD2A	2.08e-05	2	159	2	33414172
Pubmed	The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.	SH3PXD2B SH3PXD2A	2.08e-05	2	159	2	27802184
Pubmed	Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas.	PRUNE2 OBSCN	2.08e-05	2	159	2	17360660
Pubmed	Slack Potassium Channels Modulate TRPA1-Mediated Nociception in Sensory Neurons.	LBX1 KCNT1	2.08e-05	2	159	2	35626730
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	MIA3 SCAF8 NOA1 POLE FBRSL1 C15orf39 SYDE1 PRR12 TBC1D10B TAOK3 ZC3H4 SLTM	4.83e-05	650	159	12	38777146
Pubmed	Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.	MIA3 FAM117B PRR12 TAOK3 MAP1S TBCD	5.29e-05	143	159	6	32560809
Pubmed	Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.	IRS2 SOS1	6.21e-05	3	159	2	9651378
Pubmed	Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.	SH3PXD2B SH3PXD2A	6.21e-05	3	159	2	25259869
Pubmed	Direct interaction between Tks proteins and the N-terminal proline-rich region (PRR) of NoxA1 mediates Nox1-dependent ROS generation.	SH3PXD2B SH3PXD2A	6.21e-05	3	159	2	20609497
Pubmed	Transcriptional induction of NF-κB-inducing kinase by E2F4/5 facilitates collective invasion of GBM cells.	MAP3K14 E2F4	6.21e-05	3	159	2	37567906
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PITPNM2 CNOT11 FBRSL1 C15orf39 CNTROB SYDE1 TFE3 RING1 OCIAD1 PRICKLE3 NFKBIE RPRD2 IRS2 SNRNP70 MAP2K2	8.96e-05	1038	159	15	26673895
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	DNAH3 KIF26A C15orf39 SOCS6 LMTK3 SHANK3 ANKRD34A	1.04e-04	233	159	7	37704626
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	WIPF1 SH3PXD2B SH3PXD2A IRS2 SOS1	1.14e-04	103	159	5	21706016
Pubmed	Rare inborn errors associated with chronic hepatitis B virus infection.	NLRX1 C2	1.24e-04	4	159	2	22610944
Pubmed	RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.	RITA1 SPEN	1.24e-04	4	159	2	21102556
Pubmed	FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance.	FGF21 IRS2	1.24e-04	4	159	2	33761350
Pubmed	FoxP1 orchestration of ASD-relevant signaling pathways in the striatum.	CDS1 FBXL16 KCNT1	1.35e-04	22	159	3	26494785
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MAP1A PRSS56 FBRSL1 SIPA1 BRWD3 MYEF2 SNIP1 TBC1D10B ZNF469 ARHGEF33 LBX1 ZC3H4 IRS2 SOS1 ZNF646	1.97e-04	1116	159	15	31753913
Pubmed	Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.	RPH3A RIMS1	2.06e-04	5	159	2	12871946
Pubmed	Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells.	RPH3AL RPH3A	2.06e-04	5	159	2	14722103
Pubmed	Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity.	SH3PXD2B SH3PXD2A	2.06e-04	5	159	2	19755710
Pubmed	Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.	CAD CNTROB SNRNP70	2.53e-04	27	159	3	35709258
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	OBSCN OAZ1 LMTK3 SYDE1 BRWD3 ANO8 RING1 SH3PXD2A CGREF1 LRRC56 C2 IRS2 SNRNP70 ELL	2.65e-04	1021	159	14	26760575
Pubmed	Piccolo, a presynaptic zinc finger protein structurally related to bassoon.	RPH3AL RPH3A	3.08e-04	6	159	2	10707984
Pubmed	TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.	TFE3 IRS2	3.08e-04	6	159	2	16327801
Pubmed	cAMP-GEFII is a direct target of cAMP in regulated exocytosis.	RPH3A RIMS1	3.08e-04	6	159	2	11056535
Pubmed	De novo gene disruptions in children on the autistic spectrum.	LMTK3 RIMS1	3.08e-04	6	159	2	22542183
Pubmed	Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.	DISC1 TRMT44	3.08e-04	6	159	2	21659360
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	CAD NLRX1 MYEF2 PTPRN2 CGREF1 NECAB3 SPEN	3.42e-04	283	159	7	18854154
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CNOT11 IPO8 C15orf39 E2F4 FAM117B ANKLE2 SYDE1 PDF FAM117A OCIAD1 SH3PXD2A TBC1D1 ANKRD34A TBCD WDR24 CHST3	3.84e-04	1321	159	16	27173435
Pubmed	Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.	MAP2K2 SOS1	4.30e-04	7	159	2	19206169
Pubmed	Investigation of gene dosage imbalances in patients with Noonan syndrome using multiplex ligation-dependent probe amplification analysis.	MAP2K2 SOS1	4.30e-04	7	159	2	20302979
Pubmed	Prrxl1 is required for the generation of a subset of nociceptive glutamatergic superficial spinal dorsal horn neurons.	LBX1 LHX5	4.30e-04	7	159	2	20503365
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	CAD ANKLE2 ZC3H4 RPRD2 IRS2 SNRNP70 MAP2K2 SPEN PRRC2A	5.41e-04	503	159	9	16964243
Pubmed	Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci.	ZC3H4 TBC1D1	5.71e-04	8	159	2	16416088
Pubmed	Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients.	PTPRN2 CHST3	5.71e-04	8	159	2	18398821
Pubmed	Ectopic HOXA5 expression results in abnormal differentiation, migration and p53-independent cell death of superficial dorsal horn neurons.	LBX1 LHX5	5.71e-04	8	159	2	16139370
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	OBSCN ARHGEF17 SOS1	7.03e-04	38	159	3	11756498
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	MYEF2 KANSL3 SH3PXD2B KCNT1 EBF4	7.12e-04	153	159	5	10718198
Pubmed	Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin.	LBX1 LHX5	7.32e-04	9	159	2	20004188
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	CAD WIPF1 MAP1S RPRD2 SNRNP70	7.33e-04	154	159	5	16055720
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PITPNM2 MIA3 CAD MAP1A VPS33A ANKLE2 RPH3A SHANK3 MYEF2 ANO8 MAP1S AJM1 RIMS1 SNRNP70	7.78e-04	1139	159	14	36417873
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	WIPF1 SHANK3 PTPRN2 PRICKLE3 RIMS1 SPEN SOS1	8.32e-04	329	159	7	17474147
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MKRN3 DCHS2 SYNM ADAM23 APC2 OAZ1 RPH3A BRWD3 FBXL16 MAP1S RNF38 NECAB3 SNRNP70 PRRC2A SOS1	8.53e-04	1285	159	15	35914814
Pubmed	Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936.	DISC1 SHANK3	9.12e-04	10	159	2	19077115
Pubmed	Prader-Willi Syndrome	MKRN3 NPAP1	9.12e-04	10	159	2	20301505
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	FOXD2 FOXQ1 TFAP2E E2F4 TFE3 BCL6B ZNF263 NKX2-8 LHX5	9.41e-04	544	159	9	28473536
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	OBSCN ARHGEF17 SOS1	1.01e-03	43	159	3	12376548
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	ZC3H4 IRS2 PRRC2A	1.01e-03	43	159	3	34672947
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	MIA3 CNTROB FBXL16 MAP1S SH3PXD2A TBC1D1 IRS2 MAP2K2	1.08e-03	446	159	8	24255178
Pubmed	Basic molecular fingerprinting of immature cerebellar cortical inhibitory interneurons and their precursors.	LBX1 LHX5	1.11e-03	11	159	2	19141316
Pubmed	Hoxb1 controls anteroposterior identity of vestibular projection neurons.	LBX1 LHX5	1.11e-03	11	159	2	22485187
Pubmed	The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.	RNF44 RNF38	1.11e-03	11	159	2	28536267
Pubmed	Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.	FOXD2 FOXQ1	1.11e-03	11	159	2	7683413
Pubmed	SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.	SOCS6 IRS2	1.11e-03	11	159	2	12052866
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	MAP1A LMTK3 SH3PXD2A AJM1 RIMS1 PRRC2A SOS1	1.13e-03	347	159	7	17114649
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CNOT11 IPO8 SHANK3 SYDE1 MYEF2 QSOX1 TBC1D1 RPRD2 TBCD ZNF646	1.33e-03	689	159	10	36543142
Pubmed	Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor.	E2F4 TFE3	1.33e-03	12	159	2	12748276
Pubmed	A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool.	MAP2K2 SOS1	1.33e-03	12	159	2	10704452
Pubmed	Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.	MAP1A DISC1	1.33e-03	12	159	2	19251251
Pubmed	The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.	LBX1 LHX5	1.33e-03	12	159	2	12062039
Pubmed	SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.	RPH3A RIMS1	1.33e-03	12	159	2	17803915
Pubmed	Population-specific regulation of Chmp2b by Lbx1 during onset of synaptogenesis in lateral association interneurons.	LBX1 LHX5	1.33e-03	12	159	2	23284619
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SCAF8 RNF44 ZC3H4 TBC1D1	1.36e-03	104	159	4	10470851
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	RBM12B SCAF8 C15orf39 PRR12 RPRD2	1.47e-03	180	159	5	35198878
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	WIPF1 SYDE1 SH3PXD2B PRRC2A	1.56e-03	108	159	4	19531213
Pubmed	Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord.	LBX1 LHX5	1.57e-03	13	159	2	17166926
Pubmed	Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord.	LBX1 LHX5	1.57e-03	13	159	2	22159578
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	PITPNM2 SCAF8 LMTK3 MYEF2 PRR12 TBC1D10B PRRC2A KCNT1	1.61e-03	475	159	8	31040226
Pubmed	DNA sequence and analysis of human chromosome 9.	PRUNE2 SPATA6L UCK1 SUSD1 FAM157B RNF38 KCNT1	1.63e-03	370	159	7	15164053
Pubmed	Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.	RNF38 IRS2 SPEN SOS1	1.67e-03	110	159	4	37219487
Pubmed	Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos.	MAP2K2 SOS1	1.82e-03	14	159	2	15305288
Pubmed	Positional cloning of the murine flavivirus resistance gene.	RPH3A LHX5	1.82e-03	14	159	2	12080145
Pubmed	The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.	E2F4 LBX1	1.82e-03	14	159	2	16600870
Pubmed	Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1.	LBX1 LHX5	1.82e-03	14	159	2	15528197
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	LMTK3 RPH3A	1.82e-03	14	159	2	28263302
Pubmed	TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology.	DISC1 SHANK3	1.82e-03	14	159	2	27979975
Pubmed	Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.	GEMIN4 SNRNP70	1.82e-03	14	159	2	10725331
Pubmed	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.	BRWD3 PRRC2A	1.82e-03	14	159	2	28878358
Pubmed	Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.	MAP2K2 SOS1	2.10e-03	15	159	2	18760695
Pubmed	dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development.	LBX1 LHX5	2.10e-03	15	159	2	16690754
Pubmed	Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain.	LBX1 LHX5	2.10e-03	15	159	2	17475798
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	PRUNE2 CAD MAP1A INTS5 PTPRN2 SLTM GEMIN4 PRRC2A	2.10e-03	496	159	8	31343991
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MAP3K14 FAM117B ARHGEF17 SYDE1 TBC1D10B SH3PXD2B FAM117A SH3PXD2A TBC1D1 IRS2 MAP2K2	2.11e-03	861	159	11	36931259
Pubmed	Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis.	MAP3K14 NFKBIE	2.39e-03	16	159	2	18434448
Pubmed	The Onecut Transcription Factors Regulate Differentiation and Distribution of Dorsal Interneurons during Spinal Cord Development.	LBX1 LHX5	2.39e-03	16	159	2	28603487
Pubmed	Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb.	LFNG LBX1	2.39e-03	16	159	2	24927569
Interaction	TOP3B interactions	PITPNM2 CNOT11 CAD ZNF48 KIF26A POLE NLRX1 OBSCN FBRSL1 C15orf39 CNTROB TFE3 ANO8 KANSL3 PRR12 ZNF263 SH3PXD2B INTS5 MAP1S ANKRD34A LRRC56 IRS2 SPEN PRRC2A PRRT4 ELL TBCD WDR24	3.12e-06	1470	149	28	int:TOP3B
Cytoband	Ensembl 112 genes in cytogenetic band chr12q24	PITPNM2 POLE VPS33A FBRSL1 ANKLE2 RPH3A TAOK3 RITA1 LHX5	1.52e-05	415	158	9	chr12q24
Cytoband	19q13.33	PRRG2 GARIN5A LMTK3 PRR12 FGF21	3.47e-05	106	158	5	19q13.33
Cytoband	15q11-q13	MKRN3 NPAP1	3.25e-04	8	158	2	15q11-q13
Cytoband	16p11.2	SPNS1 ZNF48 SBK1 TBC1D10B ZNF646	5.44e-04	191	158	5	16p11.2
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OBSCN ARHGEF17 ARHGEF33 SOS1	3.71e-04	66	93	4	722
GeneFamily	RNA binding motif containing	RBM12B SCAF8 MYEF2 SLTM SNRNP70 SPEN	8.10e-04	213	93	6	725
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RNF44 MAP3K14 CEACAM4 FAM117B SIPA1 ZNF263 SUOX GEMIN4	6.67e-08	150	158	8	7a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RNF44 CEACAM4 FAM117B SIPA1 ZNF263 SUOX GEMIN4	1.06e-06	149	158	7	a85a051e0d82430160967e72fa04b55f43e84513
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 MIA3 LMTK3 ARHGEF17 FBXL16 PTPRN2 SH3PXD2A	6.33e-06	195	158	7	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	MAP3K14 ARHGEF17 SYDE1 KCTD17 ZNF469 SH3PXD2B CHST3	6.33e-06	195	158	7	5562665dd3beb70e2358aa32611a337bef5731c1
Disease	Idiopathic central precocious puberty	MKRN3 KISS1R	7.17e-05	3	145	2	C0342544
Disease	complex cortical dysplasia with other brain malformations (is_implicated_in)	KIF26A APC2	1.43e-04	4	145	2	DOID:0090131 (is_implicated_in)
Disease	factor VIII measurement, coronary artery disease	MIA3 RPH3A MAP1S PRRC2A ELL	2.45e-04	113	145	5	EFO_0001645, EFO_0004630
Disease	schizophrenia (implicated_via_orthology)	DISC1 SHANK3 RIMS1 CHST3	3.57e-04	68	145	4	DOID:5419 (implicated_via_orthology)
Disease	Child Development Disorders, Specific	SHANK3 KCNT1 TBCD	3.87e-04	29	145	3	C0085997
Disease	Child Development Deviations	SHANK3 KCNT1 TBCD	3.87e-04	29	145	3	C0085996
Disease	Developmental Disabilities	SHANK3 KCNT1 TBCD	4.28e-04	30	145	3	C0008073
Disease	Precocious Puberty	MKRN3 KISS1R	4.96e-04	7	145	2	C0034013
Disease	Cryptogenic sexual precocity	MKRN3 KISS1R	4.96e-04	7	145	2	C0271527
Disease	Central Precocious Puberty	MKRN3 KISS1R	4.96e-04	7	145	2	C0342543
Disease	mean reticulocyte volume	CAD TFAP2E NUP210L NLRX1 FBRSL1 C15orf39 E2F4 RPH3A ZNF469 FAM117A IRS2 MAP2K2	6.06e-04	799	145	12	EFO_0010701
Disease	Testotoxicosis	MKRN3 KISS1R	6.59e-04	8	145	2	C1504412
Disease	fibrinogen measurement, coronary artery disease	DCHS2 MIA3 RPH3A MAP1S ELL	1.01e-03	154	145	5	EFO_0001645, EFO_0004623
Disease	Prader-Willi syndrome	MKRN3 NPAP1	1.05e-03	10	145	2	cv:C0032897
Disease	PRADER-WILLI SYNDROME	MKRN3 NPAP1	1.05e-03	10	145	2	176270
Disease	Turner Syndrome, Male	MAP2K2 SOS1	1.28e-03	11	145	2	C0041409
Disease	Female Pseudo-Turner Syndrome	MAP2K2 SOS1	1.28e-03	11	145	2	C1527404
Disease	Noonan Syndrome 1	MAP2K2 SOS1	1.28e-03	11	145	2	C4551602
Disease	Royer Syndrome	MKRN3 NPAP1	1.53e-03	12	145	2	C0265222
Disease	Prader-Willi Syndrome	MKRN3 NPAP1	1.81e-03	13	145	2	C0032897
Disease	extracellular matrix protein 1 measurement	MIA3 RPRD2	1.81e-03	13	145	2	EFO_0008126
Disease	total cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement	FBRSL1 RPH3A ZC3H4	1.81e-03	49	145	3	EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612
Disease	tonsillectomy risk measurement	SPNS1 ADAM23 RPH3A SBK1 SH3PXD2B MAP2K2	1.85e-03	260	145	6	EFO_0007924
Disease	psychosis	NALCN PRRC2A	2.10e-03	14	145	2	EFO_0005407
Disease	coronary artery disease, factor VII measurement	MIA3 RPH3A MAP1S ELL	2.23e-03	111	145	4	EFO_0001645, EFO_0004619
Disease	factor XI measurement, coronary artery disease	MIA3 RPH3A MAP1S ELL	2.54e-03	115	145	4	EFO_0001645, EFO_0004694
Disease	platelet crit	DNAH3 SPATA6L MAP1A KIF26A NUP210L MAP3K14 FBXL16 DQX1 MYLK4 RPRD2 IRS2 WDR24	2.66e-03	952	145	12	EFO_0007985
Disease	von Willebrand factor measurement, coronary artery disease	MIA3 RPH3A MAP1S ELL	2.78e-03	118	145	4	EFO_0001645, EFO_0004629
Disease	Schizophrenia	DISC1 SHANK3	3.48e-03	18	145	2	cv:C0036341
Disease	age at menopause	PITPNM2 RNF44 SH3PXD2B OCIAD1 MAP2K2 PRRC2A	3.88e-03	302	145	6	EFO_0004704
Disease	Noonan-Like Syndrome With Loose Anagen Hair	MAP2K2 SOS1	3.88e-03	19	145	2	C3501846
Disease	Costello syndrome (disorder)	MAP2K2 SOS1	3.88e-03	19	145	2	C0587248
Disease	Noonan syndrome-like disorder with loose anagen hair	MAP2K2 SOS1	3.88e-03	19	145	2	C1843181
Disease	Cardio-facio-cutaneous syndrome	MAP2K2 SOS1	3.88e-03	19	145	2	C1275081

Protein segments in the cluster

Peptide	Gene	Start	Entry
ERARAPHLPPAAPAL	FBRSL1	946	Q9HCM7
PKAPRGEEAHLPPVS	ANKLE2	716	Q86XL3
APPGRCFTRERHPVP	LINC00242	106	Q5T6M2
RDLREQPPPASTPGH	CEACAM4	186	O75871
PRLEPPRAHDPLADV	ELL	386	P55199
RDPVRNLHPPKDEGP	ADAM23	771	O75077
PGPREAVSPPHREGE	CDS1	11	Q92903
RILDIPDGHRAPAPP	FAM117A	236	Q9C073
PPAGPAPHVRCRLDI	AJM1	176	C9J069
ALPAPAPRSHGPTVR	AJM1	831	C9J069
EFPRAPPADGVAPRL	ARHGEF33	711	A8MVX0
HGEAPDFSRPPQHRP	APCDD1L	456	Q8NCL9
AFAALHRGRPPELPV	BRWD3	121	Q6RI45
FHPVFKPPRPLEGRI	C7orf31	321	Q8N865
ALRHVEPGEPLAPSP	CGREF1	146	Q99674
AARPVYPPHEGREIP	CAVIN4	321	Q5BKX8
ADHISRPFSPRRPPL	CBY3	81	A6NI87
EGAAPPIPPRLHSED	DISC1	726	Q9NRI5
LSRRHSTEGPEDPPP	ANKRD34A	286	Q69YU3
AARAHEEPPGLLAPP	TFAP2E	106	Q6VUC0
APGSPEREPPAILFR	ANO8	666	Q9HCE9
GRPAPAASPEHRRPS	ANKRD63	196	C9JTQ0
GEEGEPHSISPRPRP	MAP2K2	286	P36507
PPQEHFRRPPPEHFR	RBM12B	726	Q8IXT5
PEHFRRPPPEHFRRP	RBM12B	736	Q8IXT5
PPEHFRRPPPEHFRR	RBM12B	751	Q8IXT5
EHFRRPPPEHFRRPP	RBM12B	761	Q8IXT5
FRRPPPEHFRRPPQE	RBM12B	771	Q8IXT5
LLADPALPAGRHPPV	PLA2G15	26	Q8NCC3
VPAEGPEASRPPKLH	QSOX1	596	O00391
TRPPDRPEGPHTSRI	PTPRN2	676	Q92932
PVAVPEPIGFPTRAH	ARHGEF17	981	Q96PE2
GLRSITHFGRPPFEP	DUOX1	1486	Q9NRD9
RPEPPETGVSHLRPQ	FAM47C	211	Q5HY64
LRPEPPETGVSHLRP	FAM47C	546	Q5HY64
RPEPPETGVSRLHPE	FAM47C	691	Q5HY64
GHPRPLAEPLAPRDV	LFNG	101	Q8NES3
HDEPEERPAPPRFHT	MAP1A	756	P78559
PRPHRGELSPSFLNP	MAP1A	2441	P78559
FGVPRHDPLPDPLKV	MAP1S	816	Q66K74
PEGRQLIAPPELHPR	ERVS71-1	421	P61550
GPAQTFRRPAREHPP	EPHX4	46	Q8IUS5
RAPRSKVPPPRDFHI	C2	716	P06681
AHPNRPRAAALAPGP	C17orf58	151	Q2M2W7
DPAPRLPLPHVGALS	NFKBIE	231	O00221
PEHKDPPPEVGRSFL	INPP4B	131	O15327
APEEPHGLSPLLPAR	KCNT1	26	Q5JUK3
RLEEHGSPPEPLFPN	LMTK3	541	Q96Q04
PPRPLGEFSSPRSRH	BAIAP2L2	256	Q6UXY1
EATARPRAPEHPAPP	FAM157A	176	C9JC47
SPHRDPAPRGPARFL	FGF21	151	Q9NSA1
RAPEHPAPPATAVRG	FAM157C	186	P0CG43
IPAPPAPFDHRIVTA	MYLK4	81	Q86YV6
PGPSDPAAPHAELLR	KISS1R	351	Q969F8
LEPPLAGPHAADNPR	LHX5	326	Q9H2C1
PFHPRTVALDPDRTP	KIF26A	756	Q9ULI4
PPDFVPIIPALSRHR	KIF26A	811	Q9ULI4
HDVTVRVVPPPRFLP	GARIN5A	36	Q6IPT2
PPLFPEGPARAFHEL	POLE	696	Q07864
QIHSAPGPRRPAPAL	GGN	396	Q86UU5
GPRRHPDEPPEDEVF	NLRX1	606	Q86UT6
DAQHLPRREPEPRAP	NKX2-8	21	O15522
PHPPARKASPGLERA	PITPNM2	886	Q9BZ72
HLRRLVLGPPEPPFS	PDF	51	Q9HBH1
EIVRPGHPLVPKRPD	OAZ1	196	P54368
PAGGSRPHPLRPEAE	KCTD17	266	Q8N5Z5
LERPEPPPTRFHRVH	NEURL2	16	Q9BR09
IVHIPREPGERPSPI	DQX1	221	Q8TE96
PPGTAFRLPVAHDPD	DCHS2	181	Q6V1P9
APRHGPVPAEAPELK	RIMS1	451	Q86UR5
RPIGDIPRIPESSHP	RIMS1	691	Q86UR5
HPRGFLRPSASLPEE	OBSCN	6821	Q5VST9
DFREPNAEVPRPIPH	OCIAD1	6	Q9NX40
GPEEPSRFLRGAPHR	PRICKLE3	421	O43900
PPDPHRGAKVIRADP	IRS2	1126	Q9Y4H2
GEATARPRAPEHPAP	FAM157B	176	P0CG42
PPPLHPAPAREESAR	FOXO3B	61	A0A2Z4LIS9
PSEPPAVHPRGREPA	APC2	1591	O95996
ERPRHNFPVVRSLPP	CEFIP	1226	Q711Q0
PRRSEGHPDPPTESR	BCL6B	161	Q8N143
VFAPLLRLSPPPGDH	E2F4	376	Q16254
ARSRYEHIPGPPRPS	CYP46A1	26	Q9Y6A2
RLELTLAAPPHPGPA	DNAH3	6	Q8TD57
VIPRHPGDPERLPKE	EBF4	356	Q9BQW3
DIPDGHRAPPPLVQR	FAM117B	371	Q6P1L5
RRRESLFHGPPPAPA	C2CD4D	101	B7Z1M9
RARAPPHLPGTQDPL	DNAH14	86	Q0VDD8
VVVPGHGPPFRVLRE	MBLAC1	226	A4D2B0
RPEPPETGVSHIRPG	FAM47A	236	Q5JRC9
HVIFARTDADAPPPP	KANSL3	106	Q9P2N6
PGEERRRSPLDHLPP	LBX1	11	P52954
LGSDSHPPLLPDRPR	GJB5	251	O95377
PSPLEHGTPFQREPV	RPRD2	1196	Q5VT52
RPPLDGRDHFGRPPV	SCAF8	1051	Q9UPN6
SHRARKPPGDRPPAA	SBK1	326	Q52WX2
SREHPVVGHPDPALP	NOA1	121	Q8NC60
PEPGGEIELVFRPHP	RING1	256	Q06587
PDHRAERPFPEEDPG	CNTROB	676	Q8N137
PRFAHSGPPRQRPLS	COX8C	26	Q7Z4L0
LSHRAPVPAPGLRPE	FOXQ1	216	Q9C009
PRHIEVFPPFRLLPE	NUP210L	1076	Q5VU65
PAPALRESPLHPARE	PRSS56	431	P0CW18
LHAQPRELSPRAPGP	MAP3K14	686	Q99558
REPPPGEAIFPFNIH	IPO8	71	O15397
RADDPHFRPLPTEPA	RPH3AL	171	Q9UNE2
HFRPLPTEPAEREPR	RPH3AL	176	Q9UNE2
RAPRDVLPHGHEPPA	FOXD2	46	O60548
PGHPAERPPLATDEK	FBXL16	86	Q8N461
SFRRPHPDGDVPPQG	HSFX1	76	Q9UBD0
ERPGPSPLPHRDRDR	SNRNP70	221	P08621
AKERGHPAQRPEPSP	SYDE1	26	Q6ZW31
PFTAGEEPVLVPRPH	HHLA1	421	C9JL84
PGPLDQPLLRERFHP	SPATA6L	321	Q8N4H0
CPFAHGPAELRPPRT	TRMT44	736	Q8IYL2
APEPKHPARAPARGD	RPH3A	191	Q9Y2J0
EEPRAFHPPNVSPRL	RNF38	156	Q9H0F5
PEVAPPAHRRPDHSG	SNIP1	36	Q8TAD8
PPHRVPRSLDFGDVP	PRUNE2	1481	Q8WUY3
TGPAAPPPRLREVHD	SYNM	171	O15061
VPPGRRDLPLHPRGF	MIA3	1821	Q5JRA6
PGEPRREPHPAEAEK	MYEF2	26	Q9P2K5
ARPPRAAELSHPSPV	LRRC56	526	Q8IYG6
PPAPHDGDRKELPRE	PRRC2A	1711	P48634
RPDITHPRHPREAGP	SLTM	861	Q9NWH9
PRDIPHLPGDRPDFT	SIMC1	341	Q8NDZ2
LTPHTFEPRPVRGPL	SIPA1	36	Q96FS4
EAGHGDPRPEPRPTQ	TAOK3	406	Q9H2K8
ALDETPVAGPPHLRP	INTS5	91	Q6P9B9
SHGLEPAAPSPRLRP	PRR12	856	Q9ULL5
RREPGHPELSIPVTP	OR8S1	326	Q8NH09
EVDLHSIAGPPVPPR	SOS1	1281	Q07889
PARNPPRFGHPSSVR	NPAP1	101	Q9NZP6
PREAPLRAIHPAGPS	RITA1	156	Q96K30
EEPPRPAVAGPRRHV	CHST3	121	Q7LGC8
GPHPRRAVEPAAGPL	LINC01465	61	Q8N7H1
EHSGPPIVIRDSPVP	C15orf39	456	Q6ZRI6
GPKPPIESHFRPEFI	CNOT11	271	Q9UKZ1
AELPVTHPAGVRPPI	RHBDD3	221	Q9Y3P4
HRGERARPPPPSTLL	ZNF48	501	Q96MX3
SPAPEADRPHQRPFL	UCK1	11	Q9HA47
GSKHRARAAPDPPPL	YIF1A	11	O95070
APFPVAPVPAHLRRG	MKRN3	56	Q13064
LPAPAPAPHGEARIL	SPEN	3256	Q96T58
GHTLSRPPPAQVPRE	TFE3	161	P19532
FAREPSPTHRGPRPG	SHANK3	981	Q9BYB0
SGERRPAQPHRPSPA	SH3PXD2A	581	Q5TCZ1
AKHIPPARDSRRPEP	SH3PXD2B	566	A1X283
PPRGAVERHSDLPPL	SPNS1	241	Q9H2V7
PPLPEVEFFTVHRGP	SUSD1	586	Q6UWL2
RPPHLPVEERRASAP	RNF44	61	Q7L0R7
PPHAAPTGSQEPVRR	TBC1D1	216	Q86TI0
GVHDAPPPPYTSLRR	PRRG2	186	O14669
RPPRPKEATPHLQGE	ZNF646	106	O15015
EREGQPPEAPRPLFF	PRRT4	331	C9JH25
APLVAPPRRHGAPAA	TBC1D10B	6	Q4KMP7
VGNRPSIHREAVPPP	WIPF1	271	O43516
RFGVPSPSTLEPHPR	TNXA	176	Q16473
LPPRIHRASDPGLPA	CAD	1851	P27708
LKPIFHAEERRVPPP	nan	81	Q6ZVL8
LDPLPGHPLRDPRSQ	ZC3H4	941	Q9UPT8
RPGALEHPAAPRLVP	ZC3H12D	46	A2A288
APREPFAHSLPPARG	ZC3H12D	321	A2A288
PPAAPRVPADAHAGL	ZNF469	776	Q96JG9
FDSPPIPHVPHRGEL	TBCD	931	Q9BTW9
PLPRDHGFPVRVVVP	SUOX	356	P51687
RILPGPHFEERQPLP	VPS33A	516	Q96AX1
AFPLRHEIVDTPPGP	WDR24	571	Q96S15
RAGHDDVPPLSPLLP	SOCS6	301	O14544
HFRRPEPCREPLASP	ZNF669	71	Q96BR6
PDPGPSPEASHLRFR	ZNF263	31	O14978
PALDEFPHPPKRLRS	GEMIN4	191	P57678
SLLAHNPFAGRPPPR	LMF1	496	Q96S06
QPLHLPPRPDNDGFR	NALCN	1186	Q8IZF0
RPGPHSVPSQAPRLE	NECAB3	266	Q96P71