Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	supraspliceosomal complex	RBMXL1 RBMX	3.22e-05	4	49	2	GO:0044530
GeneOntologyCellularComponent	tRNA-splicing ligase complex	FAM98A FAM98C	1.49e-04	8	49	2	GO:0072669
GeneOntologyCellularComponent	protein complex involved in cell-matrix adhesion	EMILIN2 TNXB	7.16e-04	17	49	2	GO:0098637
Domain	DUF2465	FAM98A FAM98C	1.86e-05	3	47	2	PF10239
Domain	Uncharacterised_FAM98	FAM98A FAM98C	1.86e-05	3	47	2	IPR018797
Domain	RRM_1	REXO5 G3BP1 RBMXL1 SCAF8 RBMX	1.71e-04	208	47	5	PF00076
Domain	RBM1CTR	RBMXL1 RBMX	1.72e-04	8	47	2	PF08081
Domain	RBM1CTR	RBMXL1 RBMX	1.72e-04	8	47	2	IPR012604
Domain	RRM	REXO5 G3BP1 RBMXL1 SCAF8 RBMX	2.08e-04	217	47	5	SM00360
Domain	RRM_dom	REXO5 G3BP1 RBMXL1 SCAF8 RBMX	2.57e-04	227	47	5	IPR000504
Domain	RRM	REXO5 G3BP1 RBMXL1 SCAF8 RBMX	2.73e-04	230	47	5	PS50102
Domain	-	REXO5 G3BP1 RBMXL1 SCAF8 RBMX	3.58e-04	244	47	5	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	REXO5 G3BP1 RBMXL1 SCAF8 RBMX	4.62e-04	258	47	5	IPR012677
Domain	NPIP	NPIPB13 NPIPB5	5.53e-04	14	47	2	IPR009443
Domain	RRM_dom_euk	RBMXL1 RBMX	1.52e-03	23	47	2	IPR003954
Domain	RRM_1	RBMXL1 RBMX	1.52e-03	23	47	2	SM00361
Domain	-	KASH5 SPATA21 NINL DUOX2	4.15e-03	261	47	4	1.10.238.10
Domain	EF-hand-dom_pair	KASH5 SPATA21 NINL DUOX2	5.80e-03	287	47	4	IPR011992
Domain	EFh	SPATA21 NINL DUOX2	7.34e-03	158	47	3	SM00054
Pubmed	Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia.	RBMXL1 RBMX	5.83e-06	3	49	2	34458856
Pubmed	RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet.	RBMXL1 RBMX	5.83e-06	3	49	2	17188681
Pubmed	RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene.	RBMXL1 RBMX	5.83e-06	3	49	2	10391207
Pubmed	SAFB1, an RBMX-binding protein, is a newly identified regulator of hepatic SREBP-1c gene.	RBMXL1 RBMX	1.16e-05	4	49	2	19403048
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	WIZ FURIN NFX1 ZNF500 NINL MICAL3 MARVELD3 MLXIP MAST2	2.09e-05	1105	49	9	35748872
Pubmed	Identification of transcripts with enriched expression in the developing and adult pancreas.	HOXB1 BTK NKX2-3 EMILIN2 CHD3 MARVELD3 KIF1C	2.59e-05	624	49	7	18554416
Pubmed	Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.	G3BP1 RBMX FAM98A	5.53e-05	52	49	3	26265008
Pubmed	Physical map of 17p13 and the genes adjacent to p53.	FGF11 CHD3	8.69e-05	10	49	2	10662545
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	WIZ G3BP1 RBMX FAM98A TASOR AQR	1.21e-04	551	49	6	34728620
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	RBMXL1 CARMIL3 DUOX2 MICAL3 MLXIP TNXB	1.22e-04	552	49	6	10737800
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	REXO5 G3BP1 RBMXL1 SCAF8 RBMX	1.28e-04	347	49	5	16033648
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	WIZ G3BP1 RBMX CHD3 FAM98A TASOR AQR	1.75e-04	847	49	7	35850772
Pubmed	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	G3BP1 RBMX NFX1 CHD3 FAM98A	2.05e-04	384	49	5	31059266
Pubmed	USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.	RBMX FGF11 FAM98A	2.39e-04	85	49	3	29228324
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SCAF8 MICAL3 MLXIP MARCHF4 AQR	2.67e-04	407	49	5	12693553
Pubmed	DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.	G3BP1 RBMX AQR	2.74e-04	89	49	3	22446626
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SCAF8 MICAL3 CHD3 MAST2 TASOR AQR	2.94e-04	650	49	6	38777146
Pubmed	Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.	CACNA1D TNXB	4.01e-04	21	49	2	25249183
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	WIZ CHD3 AQR	4.21e-04	103	49	3	32744500
Pubmed	Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development.	HOXB1 MARCHF4	4.41e-04	22	49	2	25079229
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	G3BP1 RBMXL1 RBMX FAM98A MAST2	4.77e-04	462	49	5	31138677
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	GEMIN7 G3BP1 RBMXL1 RBMX FAM98A AQR	4.80e-04	713	49	6	29802200
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	GEMIN7 G3BP1 RBMXL1 RBMX FAM98A AQR	5.48e-04	731	49	6	29298432
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	DUOX2 CHSY3	6.18e-04	26	49	2	33905568
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	G3BP1 RBMX CHD3 FAM98A TASOR AQR	6.66e-04	759	49	6	35915203
Pubmed	Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.	G3BP1 RBMX FAM98A	6.73e-04	121	49	3	34029587
Pubmed	Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.	G3BP1 FAM98A	7.18e-04	28	49	2	38492217
Pubmed	Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.	G3BP1 RBMX	8.25e-04	30	49	2	15782174
Pubmed	SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation.	G3BP1 RBMXL1 FAM98A	8.29e-04	130	49	3	32905556
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RBMXL1 RBMX BAG1 DDRGK1 DUOX2 CHD3 FAM98A TASOR	8.49e-04	1442	49	8	35575683
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	G3BP1 RBMX NFX1 FAM98A AQR KIF1C	9.16e-04	807	49	6	22681889
Pubmed	Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.	SCAF8 RBMX	1.06e-03	34	49	2	11101529
Pubmed	HSP90 Shapes the Consequences of Human Genetic Variation.	FANCF BAG1	1.19e-03	36	49	2	28215707
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	NFX1 NINL MICAL3 MLXIP MAST2 KIF1C	1.22e-03	853	49	6	28718761
Pubmed	ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2.	G3BP1 FAM98A	1.32e-03	38	49	2	30629181
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	WIZ SCAF8 RBMX CHD3 AQR	1.34e-03	582	49	5	20467437
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	WIZ G3BP1 CHD3 AQR	1.36e-03	341	49	4	32971831
Interaction	SNRPD1 interactions	GEMIN7 G3BP1 RBMX BAG1 NFX1 DDRGK1 FGF11 CHD3	1.25e-06	347	47	8	int:SNRPD1
Interaction	SRSF3 interactions	G3BP1 RBMXL1 RBMX BAG1 NFX1 DDRGK1 FGF11 CHD3 AQR	2.78e-06	522	47	9	int:SRSF3
Interaction	PRPF19 interactions	RBMX BAG1 NFX1 NINL DDRGK1 FGF11 CHD3 AQR	8.51e-06	450	47	8	int:PRPF19
Interaction	RTRAF interactions	G3BP1 NFX1 DDRGK1 CHD3 FAM98A FAM98C	1.23e-05	222	47	6	int:RTRAF
Interaction	MATR3 interactions	G3BP1 RBMXL1 RBMX BAG1 NFX1 DDRGK1 FGF11 CHD3 TASOR	1.73e-05	655	47	9	int:MATR3
Interaction	HNRNPAB interactions	G3BP1 RBMX BAG1 NFX1 DDRGK1 FGF11 CHD3	2.26e-05	371	47	7	int:HNRNPAB
Interaction	HNRNPA1 interactions	G3BP1 SCAF8 RBMX BAG1 NFX1 DDRGK1 FGF11 CHD3 TASOR AQR	5.21e-05	945	47	10	int:HNRNPA1
Interaction	ILF2 interactions	RBMXL1 RBMX BAG1 NFX1 DDRGK1 CHD3 AQR KIF1C	5.91e-05	590	47	8	int:ILF2
Interaction	RPL22 interactions	G3BP1 BAG1 NFX1 NINL DDRGK1 FGF11 CHD3	6.67e-05	440	47	7	int:RPL22
Interaction	ELAVL2 interactions	G3BP1 RBMXL1 RBMX DDRGK1 AQR	7.48e-05	188	47	5	int:ELAVL2
Interaction	DDX1 interactions	G3BP1 BAG1 NFX1 DDRGK1 CHD3 FAM98A FAM98C	9.17e-05	463	47	7	int:DDX1
Interaction	RPS12 interactions	G3BP1 BAG1 NFX1 NINL DDRGK1 CHD3	9.66e-05	321	47	6	int:RPS12
Interaction	HNRNPD interactions	G3BP1 RBMX BAG1 NFX1 NINL DDRGK1 FGF11 CHD3	1.02e-04	638	47	8	int:HNRNPD
Interaction	DDX3X interactions	G3BP1 RBMX BTK NFX1 DDRGK1 FGF11 CHD3 FAM98A	1.17e-04	651	47	8	int:DDX3X
Interaction	HNRNPA3 interactions	G3BP1 RBMX BAG1 NFX1 DDRGK1 FGF11 CHD3	1.69e-04	511	47	7	int:HNRNPA3
Interaction	RPL18 interactions	G3BP1 BAG1 NFX1 NINL DDRGK1 FGF11 CHD3	1.71e-04	512	47	7	int:RPL18
Interaction	SNRPB interactions	GEMIN7 RBMX DDRGK1 MICAL3 CHD3 TASOR AQR	1.81e-04	517	47	7	int:SNRPB
Interaction	IQCF1 interactions	REXO5 DDRGK1 TASOR	2.16e-04	50	47	3	int:IQCF1
Interaction	RPS23 interactions	G3BP1 BAG1 NFX1 NINL DDRGK1 CHD3	2.18e-04	373	47	6	int:RPS23
Interaction	FAM98A interactions	G3BP1 NFX1 DDRGK1 CHD3 FAM98A	2.21e-04	237	47	5	int:FAM98A
Interaction	SNRPD3 interactions	GEMIN7 RBMX BAG1 DDRGK1 FGF11 AQR	2.41e-04	380	47	6	int:SNRPD3
Interaction	ERH interactions	BAG1 NFX1 DDRGK1 FGF11 CHD3	2.58e-04	245	47	5	int:ERH
Cytoband	17q21.3	HOXB1 ADAM11	1.33e-04	16	49	2	17q21.3
Cytoband	3p14.3	CACNA1D TASOR	4.76e-04	30	49	2	3p14.3
Cytoband	16p12.2	NPIPB4 NPIPB5	7.26e-04	37	49	2	16p12.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	REXO5 NPIPB4 NPIPB5	8.39e-04	172	49	3	chr16p12
GeneFamily	RNA binding motif containing	G3BP1 RBMXL1 SCAF8 RBMX	5.86e-04	213	33	4	725
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3K27ME3	HOXB1 NKX2-3 FGF11 MARVELD3 ADAM11 MARCHF4 TNXB FCHO1	1.27e-05	591	49	8	M2019
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3K27ME3	HOXB1 NKX2-3 FGF11 MARVELD3 ADAM11 MARCHF4 TNXB FCHO1	1.44e-05	601	49	8	MM866
Coexpression	GSE17721_4_VS_24H_GARDIQUIMOD_BMDC_DN	FANCF BTK NFX1 AKIP1 FCHO1	3.49e-05	199	49	5	M4147
Disease	pyridoxate measurement	CACNA1D EMILIN2	1.03e-03	31	45	2	EFO_0010527
Disease	colorectal cancer, endometrial neoplasm	HOXB1 SCAF8	1.88e-03	42	45	2	EFO_0004230, MONDO_0005575
Disease	interleukin 12 measurement	RBMX NFX1	2.98e-03	53	45	2	EFO_0004753

Protein segments in the cluster

Peptide	Gene	Start	Entry
KNPPPERQIPRRGEE	BTK	71	Q06187
GPQRVLPGEREERPP	AKIP1	66	Q9NQ31
QLDTRVRQEPPGGPP	ADAM11	66	O75078
PGREPRQSEPPAQRG	BAG1	26	Q99933
RVIEDGPEPRPNLRG	AQR	606	O60306
RVAQPGPLEPEEPRA	DDRGK1	46	Q96HY6
RVRGEPVPEPRPDSG	AMHR2	176	Q16671
GGPPRREPLPSRRDV	RBMX	191	P38159
PPPEPKRRRVGDVEP	NPIPB12	831	F8W0I5
GDIPENPPERPARRE	KASH5	471	Q8N6L0
LPGLSRREREPEPPA	FCHO1	291	O14526
RPPREPAQPPREEVR	MICAL3	1496	Q7RTP6
QPPLSRRPQEELEPG	FANCF	211	Q9NPI8
LPRGRQEEPRPAPTG	ARMC9	721	Q7Z3E5
QEEPEVQGPPDPGRR	CARMIL3	1321	Q8ND23
IRIPPGDPVFDPDQR	DUOX2	131	Q9NRD8
EGARPRPGRNPPKQE	NFX1	251	Q12986
EQARLERERGVPPPP	KIF1C	601	O43896
PPPEPKRRRVGDVEP	NPIPB5	1036	A8MRT5
PPPEPKRRRVGDVEP	NPIPB4	1041	C9JG80
RPARPDRGPEPQLKG	FGF11	56	Q92914
PRAGPGREEPPRRQQ	MLXIP	61	Q9HAP2
REREEGRVPPAPPGC	HOXB1	261	P14653
VPPPRPLQGRSEREF	CHD3	536	Q12873
PPQRGPRPIREAGEQ	G3BP1	311	Q13283
PPRLPPEVEAGQRLR	FURIN	691	P09958
APDGRRAPLRPEVPE	GEMIN7	26	Q9H840
PQPQRKGDPGRRRPE	MARVELD3	141	Q96A59
RGPREVVGREPPPVP	MARCHF4	91	Q9P2E8
QPPPPDRREDGVQRA	MAST2	11	Q6P0Q8
NVPDRGGRPNELEPP	FAM98C	311	Q17RN3
TAEDPGRRPVLPQRP	EMILIN2	816	Q9BXX0
PPVDVRDVVGRPIDP	SCAF8	1031	Q9UPN6
RDVVGRPIDPREGPG	SCAF8	1036	Q9UPN6
PPPRRVAVPVLVRDG	NKX2-3	221	Q8TAU0
EPEVPAGPRPRRISE	CACNA1D	836	Q01668
PPPEPKRRRVGDVEP	NPIPB13	1041	A6NJU9
RAQEPPGRGPRVVPH	GDF6	81	Q6KF10
LDRPPPGLQRPEDRF	SLC29A3	36	Q9BZD2
GGPPRREPLPSRRDV	RBMXL1	191	Q96E39
PPPEVRDIGERREPD	SPATA21	46	Q7Z572
RVPDRGGRPNEIEPP	FAM98A	301	Q8NCA5
QGPERLPGPAPRENI	WIZ	16	O95785
LEEPPQGPLPRGSQR	NINL	761	Q9Y2I6
PRGPEEPERPVRRSF	TASOR	86	Q9UK61
PPPLQQRRRGREPEG	CHSY3	106	Q70JA7
ELPPKEERPCGGPRR	C10orf90	121	Q96M02
RLPGLRVVPPPFEQE	REXO5	691	Q96IC2
RDGRPQVVPVEGPER	TNXB	1196	P22105
PGQRPAPVRGLVRPD	ZNF500	291	O60304