Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentplatelet dense granule lumen

FAM3C APOH

3.20e-0414402GO:0031089
GeneOntologyCellularComponentplatelet dense granule

FAM3C APOH

7.33e-0421402GO:0042827
GeneOntologyCellularComponentlamellar body

RAB14 SPINK5

7.33e-0421402GO:0042599
DomainCARD

CARD6 NOD2

4.75e-0416382SM00114
DomainCARD

CARD6 NOD2

1.47e-0328382PF00619
DomainCARD

CARD6 NOD2

1.81e-0331382IPR001315
DomainCARD

CARD6 NOD2

2.05e-0333382PS50209
DomainSushi

CFHR5 APOH

5.01e-0352382PF00084
DomainCCP

CFHR5 APOH

5.40e-0354382SM00032
DomainSUSHI

CFHR5 APOH

5.79e-0356382PS50923
DomainSushi_SCR_CCP_dom

CFHR5 APOH

6.00e-0357382IPR000436
DomainEF_HAND_2

CACNA1B RHOT2 S100A7L2

1.15e-02231383PS50222
DomainEF_hand_dom

CACNA1B RHOT2 S100A7L2

1.16e-02232383IPR002048
Domainzf-C2H2

ZNF17 GTF3A ZNF592 ZNF559 ZNF382

1.26e-02693385PF00096
Pubmed

pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling.

SLC15A4 NOD2

3.87e-06340219570976
Pubmed

NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis.

CARD6 NOD2

7.73e-06440226976200
Pubmed

Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease.

VDR NOD2

7.73e-06440216009674
Pubmed

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling.

SLC15A4 NOD2

1.93e-05640224695226
Pubmed

The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.

GTF3A RPF2

5.77e-051040224120868
Pubmed

Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

SPINK5 NOD2

1.16e-041440216519819
Pubmed

Analyses of associations with asthma in four asthma population samples from Canada and Australia.

VDR SPINK5 NOD2

1.65e-049240319247692
Pubmed

Proteomic analysis of the mouse liver mitochondrial inner membrane.

RHOT2 BDH1 COX6B1

1.08e-0317540312865426
GeneFamilyWD repeat domain containing|Caspase recruitment domain containing|Apoptosome

CARD6 NOD2

1.28e-0330322959
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CFHR5 APOH

4.56e-03573221179
GeneFamilyEF-hand domain containing

CACNA1B RHOT2 S100A7L2

6.71e-03219323863
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF17 GTF3A ZNF592 ZNF559 ZNF382

8.05e-0371832528
DiseaseBehcet's disease (is_implicated_in)

VDR NOD2

8.88e-0436362DOID:13241 (is_implicated_in)
Diseasediabetes mellitus (is_marker_for)

APOH TFPI

1.15e-0341362DOID:9351 (is_marker_for)
Diseasepulmonary tuberculosis (is_implicated_in)

VDR NOD2

1.21e-0342362DOID:2957 (is_implicated_in)
Diseaseliver cirrhosis (is_implicated_in)

TFPI VDR

1.27e-0343362DOID:5082 (is_implicated_in)
Diseasesystemic lupus erythematosus (is_marker_for)

TFPI NOD2

1.51e-0347362DOID:9074 (is_marker_for)
DiseaseBipolar Disorder

CACNA1B ZNF592 VDR NOD2

2.64e-03477364C0005586

Protein segments in the cluster

PeptideGeneStartEntry
SMKRKALFTCPFNGD

VDR

51

P11473
KSAPALACGNAMVFK

ALDH9A1

166

P49189
FKNGMLHGDKVSFFC

APOH

286

P02749
HSKGFLVFAGCLMKD

BDH1

76

Q02338
SQKAFHMEPAQKPCF

ARHGEF4

16

Q9NR80
HGKSCMNPQKFKFDR

AKAP11

391

Q9UKA4
TKCHKKMGFSTAPDA

PRMT8

316

Q9NR22
MGKFHKACFPNSTDA

CACNA1B

246

Q00975
FTEKKFMADCPHTIG

RAB14

31

P61106
NFDPRVCGKHATMFG

TIPARP

546

Q7Z3E1
PKVHMGACFSKVFNG

MAP4K2

466

Q12851
SKACPEKHFAFKMAS

FAM3C

61

Q92520
SKEGCPTMGHFADRF

PNLIPRP3

316

Q17RR3
CAACKKPFGNSLFHM

LDB3

636

O75112
FPFCNHGKRSTMKTV

NEIL3

551

Q8TAT5
AKFVQCHFKEPAFGM

MYO15A

2051

Q9UKN7
HEFQAFMKNGKLFCP

SPINK5

31

Q9NQ38
NMSLTHFFKLKSACG

PDE12

531

Q6L8Q7
NAFCSKHASGEGAMK

GUCY1B1

431

Q02153
PEGRKKAFSTCASHM

OR8J3

231

Q8NGG0
MFLKAAGFPTASVCH

HYKK

86

A2RU49
IGSHPMCKSSQFKSD

CARD6

931

Q9BX69
KFPSAFFKGRVNMCA

DOCK11

1466

Q5JSL3
GSFAKHMVAQCVSPK

DNAAF9

321

Q5TEA3
MCSFPFVKNGHSESS

CFHR5

86

Q9BXR6
SKQSLFDSCKMSHGG

SLC15A4

291

Q8N697
FDSCKMSHGGPFTEE

SLC15A4

296

Q8N697
MKENFPNFLSGCEKS

S100A7L2

36

Q5SY68
DFHRCQKAMTAKGGD

COX6B1

36

P14854
LMFDGSDPKSFAHCA

RHOT2

491

Q8IXI1
FSKKSDCSLFMFGSH

RPF2

81

Q9H7B2
DCSLFMFGSHNKKRP

RPF2

86

Q9H7B2
ANFMCKKDFHPASKS

CIR1

6

Q86X95
FNNKLTDGCAHSMAK

NOD2

851

Q9HC29
KNGMFFGHAKQLCPN

REV1

521

Q9UBZ9
FHKCAFCPMAFKTAS

ZNF592

826

Q92610
PLKLMHSFCAFKADD

TFPI

46

P10646
HAGCGKTFAMKQSLT

GTF3A

281

Q92664
PFDHNECEKSFLMKG

ZNF382

211

Q96SR6
CGKAFINSSSFKSHM

ZNF559

386

Q9BR84
FAKHPTNGFEGCSMV

PPIP5K1

1076

Q6PFW1
KCGKFFMDSSTLISH

ZNF17

586

P17021