Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessimmunoglobulin production

IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2D-26 IGKV2-40 IGKV2-30 IGKV2-29 IGKV2-28 IGKV2-24

4.78e-08241639GO:0002377
GeneOntologyBiologicalProcessproduction of molecular mediator of immune response

IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2D-26 IGKV2-40 IGKV2-30 IGKV2-29 IGKV2-28 IGKV2-24

3.54e-06403639GO:0002440
GeneOntologyBiologicalProcessadaptive immune response

JAK1 CD274 IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2D-26 CFI IGKV2-40 IGKV2-30 IGKV2-29 IGKV2-28 IGKV2-24

7.39e-068386312GO:0002250
GeneOntologyCellularComponentimmunoglobulin complex

IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2D-26 IGKV2-40 IGKV2-30 IGKV2-29 IGKV2-28 IGKV2-24

1.66e-09166639GO:0019814
DomainKinase-like_dom

JAK1 MYLK PIK3CB FGFR1 PRKG1 TP53RK MAP4K4

1.13e-03542567IPR011009
DomainTerpenoid_cyclase/PrenylTrfase

LSS PZP

1.31e-0318562IPR008930
DomainPROTEIN_KINASE_ATP

JAK1 MYLK FGFR1 PRKG1 TP53RK MAP4K4

2.45e-03459566PS00107
DomainPROTEIN_KINASE_TYR

JAK1 FGFR1 TP53RK

3.08e-0397563PS00109
DomainTyr_kinase_AS

JAK1 FGFR1 TP53RK

3.08e-0397563IPR008266
DomainProt_kinase_dom

JAK1 MYLK FGFR1 PRKG1 TP53RK MAP4K4

3.35e-03489566IPR000719
DomainPROTEIN_KINASE_DOM

JAK1 MYLK FGFR1 PRKG1 TP53RK MAP4K4

3.49e-03493566PS50011
Domain-

CTH HDC

4.93e-03355623.90.1150.10
DomainPyrdxlP-dep_Trfase_major_sub2

CTH HDC

5.21e-0336562IPR015422
DomainProtein_kinase_ATP_BS

JAK1 MYLK FGFR1 PRKG1 MAP4K4

5.48e-03379565IPR017441
Domain-

CTH HDC

6.09e-03395623.40.640.10
DomainPyrdxlP-dep_Trfase

CTH HDC

6.72e-0341562IPR015424
DomainPyrdxlP-dep_Trfase_major_sub1

CTH HDC

6.72e-0341562IPR015421
PathwayREACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION

PIK3CB IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

1.55e-0771496M27203
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

PIK3CB IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

3.69e-0782496M27110
PathwayREACTOME_CD22_MEDIATED_BCR_REGULATION

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

2.11e-0661495M27581
PathwayREACTOME_COMPLEMENT_CASCADE

IGKV2D-40 IGKV2D-30 IGKV2D-28 CFI IGKV2-30 IGKV2-28

2.72e-06115496M19752
PathwayREACTOME_FCGR_ACTIVATION

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

3.91e-0669495M27108
PathwayREACTOME_SCAVENGING_OF_HEME_FROM_PLASMA

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

3.91e-0669495M27150
PathwayREACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

4.51e-0671495M1078
PathwayREACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

8.13e-0680495M6121
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

PIK3CB IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

9.58e-06143496M27107
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

1.16e-0586495M601
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

1.16e-0586495M27206
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

1.23e-0587495M27205
PathwayREACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS

JAK1 IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

1.46e-05154496M39007
PathwayREACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

1.89e-0595495M29842
PathwayREACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

2.19e-0598495M27152
PathwayREACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING

PIK3CB IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

4.25e-05186496M27175
PathwayREACTOME_PARASITE_INFECTION

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

4.94e-05116495M29843
PathwayREACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL

PIK3CB IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

5.37e-05194496M16312
PathwayREACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

9.82e-05134495M29840
PathwayKEGG_PANCREATIC_CANCER

JAK1 PIK3CB RALBP1 ARHGEF6

9.98e-0570494M9726
PathwayREACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

1.05e-04136495M27207
PathwayREACTOME_SARS_COV_INFECTIONS

JAK1 VPS18 IGKV2D-40 IGKV2D-30 ST6GALNAC4 IGKV2D-28 IGKV2-30 IGKV2-28

1.98e-04471498M39009
PathwayWP_PANCREATIC_ADENOCARCINOMA_PATHWAY

JAK1 PIK3CB RALBP1 ARHGEF6

2.53e-0489494M39732
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

2.67e-04166495M608
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY

PIK3CB FGFR1

4.20e-049492M47397
PathwayREACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

4.97e-04190495M8240
PathwayREACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION

PIK3CB IGKV2D-28 IGKV2-28

5.05e-0445493MM14912
PathwayREACTOME_VIRAL_INFECTION_PATHWAYS

JAK1 VPS18 UBAP1 IGKV2D-40 IGKV2D-30 ST6GALNAC4 IGKV2D-28 RPL5 IGKV2-30 IGKV2-28

8.10e-048884910M48034
PathwayREACTOME_LEISHMANIA_INFECTION

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28

9.45e-04219495M29836
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

PIK3CB IGKV2D-28 IGKV2-28

9.61e-0456493MM14815
Pubmed

Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.

IGKV2D-30 IGKV2D-29 IGKV2D-26 IGKV2-40 IGKV2-30 IGKV2-29 IGKV2-28

1.14e-107566731527668
Pubmed

The human immunoglobulin kappa locus. Characterization of the duplicated A regions.

IGKV2D-30 IGKV2-30 IGKV2-29 IGKV2-28

2.46e-09106641551402
Pubmed

Evolutionary dynamics of the human immunoglobulin kappa locus and the germline repertoire of the Vkappa genes.

IGKV2D-40 IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2D-26

7.60e-093666511298326
Pubmed

The human VK locus. Characterization of a duplicated region encoding 28 different immunoglobulin genes.

IGKV2D-28 IGKV2D-26 IGKV2-24

1.30e-0766633351922
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

EPPK1 SRSF1 ERH PARP2 IGKV2D-40 IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2D-26 RPL5 IGKV2-30 IGKV2-24

2.02e-07949661236574265
Pubmed

Studies of the interactions between the anticytokeratin 8 monoclonal antibody TS1, its antigen and its anti-idiotypic antibody alphaTS1.

IGKV2D-28 IGKV2-28

3.55e-06266212833571
Pubmed

Two V kappa germ-line genes related to the GAT idiotypic network (Ab1 and Ab3/Ab1') account for the major subfamilies of the mouse V kappa-1 variability subgroup.

IGKV2D-28 IGKV2-28

3.55e-0626623100621
Pubmed

Structural and affinity studies of IgM polyreactive natural autoantibodies.

IGKV2D-28 IGKV2-28

3.55e-0626628993018
Pubmed

V genes of oxazolone antibodies in 10 strains of mice.

IGKV2D-28 IGKV2-28

3.55e-0626621936125
Pubmed

Blockage of PD-L1 by FERMT3-mediated Wnt/β-catenin signalling regulates chemoresistance and immune evasion of colorectal cancer cells.

CD274 FERMT3

3.55e-06266235672907
Pubmed

Nucleotide sequences of the variable regions of a mouse monoclonal antibody MRK16.

IGKV2D-28 IGKV2-28

3.55e-0626622110659
Pubmed

FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway.

FGFR1 MAP4K4

3.55e-06266228771231
Pubmed

Cryoglobulinemia induced by a murine IgG3 rheumatoid factor: skin vasculitis and glomerulonephritis arise from distinct pathogenic mechanisms.

IGKV2D-28 IGKV2-28

3.55e-0626622263605
Pubmed

IgM binding to injured tissue precedes complement activation during skeletal muscle ischemia-reperfusion.

IGKV2D-28 IGKV2-28

3.55e-06266215522311
Pubmed

cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation.

CTH PRKG1

3.55e-06266223285278
Pubmed

Early induced IgM as a predictor and risk factor for severe disease outcome after West Nile virus infection.

IGKV2D-28 IGKV2-28

3.55e-06266215219549
Pubmed

Amino acid sequence of the light chain variable region from a mouse anti-digoxin hybridoma antibody.

IGKV2D-28 IGKV2-28

3.55e-0626626404298
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

EPPK1 SRSF1 ERH EHMT2 FGFR1 PRKG1 RPL5

5.34e-0635866732460013
Pubmed

The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.

SRSF1 ERH RPL5 IGKV2-40

6.07e-066266419710015
Pubmed

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

JAK1 FGFR1 GCK

9.80e-062266310932192
Pubmed

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.

JAK1 CD274

1.06e-05366231305264
Pubmed

Genome-wide open reading frame profiling identifies fibroblast growth factor signaling as a driver of PD-L1 expression in head and neck squamous cell carcinoma.

CD274 FGFR1

1.06e-05366237666053
Pubmed

Protein kinase G-regulated production of H2S governs oxygen sensing.

CTH PRKG1

1.06e-05366225900831
Pubmed

Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence.

SRSF1 RPL5

1.06e-05366223478443
Pubmed

Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit.

ERH IGKV2D-28 IGKV2-28

1.85e-052766320564261
Pubmed

The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9.

RAD1 DNAJC7

2.12e-05466211573955
Pubmed

B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells.

IGKV2D-28 IGKV2-28

2.12e-05466217023586
Pubmed

A new region of synteny between human chromosome 1p22 and mouse chromosome 5.

EVI5 RPL5

2.12e-05466210762661
Pubmed

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.

CD274 GSDMC

2.12e-05466232929201
Pubmed

Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis.

EVI5 RPL5

2.12e-05466220087403
Pubmed

Role of plasma membrane localization of the scaffold protein JSAP1 during differentiation of cerebellar granule cell precursors.

FGFR1 MAPK8IP3

2.12e-05466221156008
Pubmed

Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.

EVI5 EPPK1 VCAN MOV10L1 VPS35L UBAP1 DNAJC7 CFI WDR17 RPL5 PRNP

2.95e-051293661115342556
Pubmed

Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathways.

SLC18A2 HDC

3.53e-05566217974627
Pubmed

Cystathionine γ-lyase(CSE)/hydrogen sulfide system is regulated by miR-216a and influences cholesterol efflux in macrophages via the PI3K/AKT/ABCA1 pathway.

PIK3CB CTH

3.53e-05566226772887
Pubmed

Interactions among genetic variants from contractile pathway of vascular smooth muscle cell in essential hypertension susceptibility of Chinese Han population.

MYLK PRKG1

3.53e-05566218496125
Pubmed

The human immunoglobulin kappa locus. Characterization of the duplicated O regions.

IGKV2D-40 IGKV2-40

3.53e-0556621907917
Pubmed

Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.

PPP1R3B GCK

7.40e-05766218165236
Pubmed

Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.

EHMT2 SLC18A2 FGFR1

8.75e-054566321041608
Pubmed

Tripartite motif-containing protein 11 promotes hepatocellular carcinogenesis through ubiquitin-proteasome-mediated degradation of pleckstrin homology domain leucine-rich repeats protein phosphatase 1.

IGKV2D-29 IGKV2D-28 IGKV2-24

9.35e-054666334767673
Pubmed

Identification of NPM-ALK interacting proteins by tandem mass spectrometry.

MYLK PIK3CB MAPK8IP3

9.97e-054766314968112
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

ERH EHMT2 LSS ZFC3H1 HERC2 ALDH9A1 DNAJC7 ADGRL2 OGA MAP4K4 RPL5

1.04e-041487661133957083
Pubmed

SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer.

SRSF1 RPL5

1.27e-04966229547122
Pubmed

RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits.

SRSF1 RPL5

1.27e-04966220926688
Pubmed

High-resolution mapping of a minor histocompatibility antigen gene on mouse chromosome 2.

PRNP HDC

1.27e-0496628118101
Pubmed

FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis.

JAK1 MAPK8IP3

1.27e-04966217855365
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

JAK1 EHMT2 RALBP1 VPS35L ZFC3H1 HERC2 DNAJC7 WDR17 MAP4K4 MAPK8IP3

1.47e-041285661035914814
Pubmed

Isolation and chromosomal location of Nsk1, a novel murine putative receptor tyrosine kinase.

JAK1 FGFR1

1.58e-04106628535092
Pubmed

Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse.

PRNP HDC

1.58e-04106628462855
Pubmed

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.

IGKV2D-28 PZP IGKV2-40 IGKV2-30

1.62e-0414366422516433
Pubmed

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.

JAK1 SRSF1 IGKV2D-28 IGKV2-28

1.90e-0414966426370502
Pubmed

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4.

JAK1 FGFR1

2.31e-041266210918587
Pubmed

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.

EVI5 RPL5

2.73e-041366219525955
Pubmed

Risk alleles for multiple sclerosis in multiplex families.

EVI5 RPL5

2.73e-041366219506219
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

SRSF1 ERH CPNE1 ALDH9A1 DNAJC7 OGA MAP4K4

2.78e-0467066722990118
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

EPPK1 LSS CTH HMGCS2 ADGRL2

2.85e-0430466532235678
Pubmed

Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.

EVI5 RPL5

3.18e-041466219834503
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

JAK1 VPS18 MYLK ERH RALBP1 FGFR1 PRKG1 MAP4K4

3.20e-0491066836736316
Pubmed

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

EPPK1 SRSF1 ERH IGKV2D-28 RPL5

4.33e-0433366532665550
Pubmed

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.

EPPK1 HERC2 ALDH9A1 DNAJC7

4.68e-0418966431594818
Pubmed

An approach based on a genome-wide association study reveals candidate loci for narcolepsy.

SLC18A2 RAD1 CD274 TP53RK

5.06e-0419366420677014
Pubmed

A systematic study of nuclear interactome of C-terminal domain small phosphatase-like 2 using inducible expression system and shotgun proteomics.

EPPK1 ERH

5.32e-041866226674342
Pubmed

Human myeloperoxidase in innate and acquired immunity.

IGKV2D-28 IGKV2-28

5.32e-041866220399194
Pubmed

HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation.

JAK1 PIK3CB

5.94e-041966224073214
Pubmed

Characteristics of the immunoglobulin Vkappa genes, pseudogenes, relics and orphons in the mouse genome.

IGKV2D-28 IGKV2-28

6.59e-042066210427970
Pubmed

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

MYLK PIK3CB RALBP1 FGFR1 ARHGEF6

7.05e-0437166525241761
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

JAK1 VPS18 FGFR1 TP53RK MAP4K4

7.13e-0437266522939624
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

JAK1 ZFC3H1 HERC2 MAP4K4

7.20e-0421266433853758
Pubmed

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.

PPP1R3B GPRC6A

7.28e-042166221300955
Pubmed

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.

GCK HMGCS2 PRNP

7.50e-049366327689697
Pubmed

CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.

ERH PRKG1 HERC2

7.73e-049466337468549
Pubmed

Circular RNA profile in liver tissue of EpCAM knockout mice.

PPP1R3B GCK

7.99e-042266231524221
Pubmed

Transforming growth factor-β signaling in myogenic cells regulates vascular morphogenesis, differentiation, and matrix synthesis.

MYLK VCAN

7.99e-042266221979435
Pubmed

ATP-citrate lyase deficiency in the mouse.

GCK HMGCS2

8.75e-042366214662765
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

PROM2 CPNE1 IGKV2D-28 ALDH9A1 PZP CFI IGKV2-40 IGKV2-30

9.26e-04107066823533145
Pubmed

Fibroblast growth factor 2 regulates dopaminergic neuron development in vivo.

SLC18A2 FGFR1

9.53e-042466222537018
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

ATP2C2 OGA MAP4K4

9.80e-041026639734811
Pubmed

Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.

JAK1 FGFR1

1.03e-032566215254900
Pubmed

Role of the focal adhesion protein TRIM15 in colon cancer development.

PRNP FERMT3

1.03e-032566225450970
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

SFI1 ZFC3H1 ADAMTSL2

1.07e-031056639628581
Pubmed

Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.

JAK1 CD274

1.21e-032766219604093
Pubmed

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

SRSF1 ERH CFI RPL5 IGKV2-29

1.24e-0342166534650049
Pubmed

Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.

MYLK HMGCS2 MAP4K4 RPL5

1.31e-0324966430097533
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

SRSF1 IGKV2D-29 IGKV2D-28 RPL5 IGKV2-30 IGKV2-28

1.36e-0364166636057605
Pubmed

A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex.

PRNP HDC

1.39e-03296628617512
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

SRSF1 ERH IGKV2D-40 FGFR1 DNAJC7 RPL5 IGKV2-40 IGKV2-30

1.49e-03115366829845934
Pubmed

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.

MYLK GCK

1.49e-033066227133129
Pubmed

Heritable Thoracic Aortic Disease Overview

MYLK PRKG1

1.49e-033066220301299
Pubmed

Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.

SLC18A2 PRNP HDC

1.49e-0311866319156168
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

FNDC7 SRSF1 ERH RPL5

1.51e-0325966430404004
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

ZFC3H1 HERC2 DNAJC7

1.56e-0312066331413325
Pubmed

Murine txk: a protein tyrosine kinase gene regulated by T cell activation.

JAK1 FGFR1

1.70e-03326627542761
Pubmed

Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library.

EHMT2 RALBP1

1.80e-033366223718855
InteractionEIF3F interactions

IGKV2D-30 IGKV2D-29 IGKV2D-26 HERC2 IGKV2-40 IGKV2-30 IGKV2-29 IGKV2-28

4.27e-06296648int:EIF3F
Cytoband2p12

IGKV2D-40 IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2D-26 IGKV2-40 IGKV2-30 IGKV2-29 IGKV2-28 IGKV2-24

1.46e-1511766102p12
CytobandEnsembl 112 genes in cytogenetic band chr2p11

IGKV2D-40 IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2D-26 IGKV2-40 IGKV2-30 IGKV2-29 IGKV2-28 IGKV2-24

6.29e-132136610chr2p11
Cytoband1p22.1

EVI5 RPL5

9.82e-04326621p22.1
CytobandEnsembl 112 genes in cytogenetic band chr1p31

JAK1 CTH ADGRL2

4.18e-03224663chr1p31
Cytoband1p31.1

CTH ADGRL2

4.74e-03716621p31.1
GeneFamilyImmunoglobulin kappa locus at 2p11.2

IGKV2D-40 IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2D-26 IGKV2-40 IGKV2-30 IGKV2-29 IGKV2-28 IGKV2-24

1.35e-14834810351
CoexpressionAtlasAravindRamakr_StemCell_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_1000_k-means-cluster#5

IGKV2D-30 IGKV2D-28 HMGCS2 IGKV2-30 IGKV2-28 IGKV2-24

1.41e-05183616Arv_SC_fibroblast_1000_K5
CoexpressionAtlasAravindRamakr_StemCell-HD_top-relative-expression-ranked_500_k-means-cluster#2

IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28 IGKV2-24

3.10e-05126615Arv_SC-HD_500_K2
CoexpressionAtlasAravindRamakr_StemCell_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_500_k-means-cluster#3

IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28 IGKV2-24

4.96e-05139615Arv_SC_fibroblast_500_K3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000

JAK1 SRSF1 MYLK EHMT2 VCAN PRKG1 HERC2 MAPK8IP3 FERMT3 HDC

1.03e-048186110gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000

JAK1 SRSF1 EHMT2 VCAN PRKG1 HERC2 MAPK8IP3

1.15e-04385617gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
ToppCell3'_v3-blood-Lymphocytic_B_plasma-Plasma_cells|blood / Manually curated celltypes from each tissue

ST6GALNAC4 IGKV2D-29 IGKV2D-26 IGKV2-40 IGKV2-30 IGKV2-29 IGKV2-28

5.10e-091656671c0c24fe252b761cf879b83562e23c02f0b6489f
ToppCellCOPD-Lymphoid-B_Plasma|World / Disease state, Lineage and Cell class

IGKV2D-40 IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2-30 IGKV2-29 IGKV2-28

7.66e-09175667d73ee324479172501481b54967a0f3bd870fcf3a
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_plasma|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV2D-30 IGKV2D-28 IGKV2D-26 IGKV2-40 IGKV2-30 IGKV2-29 IGKV2-28

1.51e-08193667282b47dae6043eabb1e13d41d91c07b5ec21cd65
ToppCellhealthy_donor-Lymphocytic-Plasma_cell-IgM_Plasmablast|healthy_donor / Disease condition, Lineage, Cell class and subclass

IGKV2D-40 IGKV2D-30 IGKV2-40 IGKV2-30 IGKV2-28 IGKV2-24

1.74e-071666662b7b580bec8d9467b0deaf97098065f72dbf2a4f
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-29 IGKV2-28 IGKV2-24

2.22e-071736667e6bfe85f60834f317941b70d6e0dc3bd527d293
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-29 IGKV2-28 IGKV2-24

2.63e-07178666107dae8b00c4257697a63700e72bb434cdb8406f
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28 IGKV2-24

2.72e-07179666837ed81f18257f444eaeadc4fac89deedd4e3061
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV2D-40 IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28 IGKV2-24

2.72e-07179666b6ee4f41d8fb5f047b7bdd8489dda0a89fc6d43f
ToppCell3'_v3-blood-Lymphocytic_B_plasma|blood / Manually curated celltypes from each tissue

IGKV2D-30 ST6GALNAC4 IGKV2D-29 IGKV2-40 IGKV2-30 IGKV2-28

3.09e-071836662477183a290b2c45b6fa091ed76969a3826fe3d9
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2-30 IGKV2-29 IGKV2-28

3.09e-07183666cf5c98f451a568308c52da5c926543dd4836c6b2
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2-30 IGKV2-29 IGKV2-24

3.30e-071856666ec009e48e50471c28e914c402f500e56a88f8f2
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2-30 IGKV2-29 IGKV2-24

3.30e-07185666f49ad6401b2abd089e30eba245b11b5031ea2318
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV2D-30 IGKV2D-28 IGKV2D-26 IGKV2-30 IGKV2-29 IGKV2-28

4.49e-07195666df009b18898c10686f75cf72b4ec0eff18f5bb50
ToppCellTracheal-10x5prime-Immune_Lymphocytic-B|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV2D-30 IGKV2D-26 IGKV2-30 IGKV2-29 IGKV2-28 IGKV2-24

4.77e-071976662662138671262b30508c5759038bcdcfe6551696
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_cell-B_naive|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2D-26 IGKV2-29 IGKV2-28

5.06e-071996668e02d3a066e79e0f2024a10738e0ea070513ef19
ToppCellTCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue-2|TCGA-Stomach / Sample_Type by Project: Shred V9

IGKV2D-30 IGKV2D-28 IGKV2D-26 IGKV2-40 IGKV2-28

1.15e-061246659d62f997a1a389386e8d83652bdf109c2a1c96d8
ToppCelldroplet-Liver-nan-3m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B CTH HMGCS2 PZP CFI

3.02e-06151665cc9632b58522e2ba3ad36a0b8d37c7c9c8b636c4
ToppCelldroplet-Liver-nan-3m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B CTH HMGCS2 PZP CFI

3.02e-061516657758cfbe8dca849c90bd6e8bc63310e53beeb8fd
ToppCelldroplet-Liver-nan-3m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B CTH HMGCS2 PZP CFI

3.02e-06151665b4a0546c1573b4b2290890307f2a5daf3a7cbb37
ToppCelldroplet-Liver-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B CTH HMGCS2 PZP CFI

3.12e-061526651febeeb7376e34b9f86c81b2cb1314ee12408864
ToppCelldroplet-Liver-nan-3m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B CTH HMGCS2 PZP CFI

3.12e-06152665faa92f7c5a6db9f1eb7d8ec930ba7c8ed9fd1bf1
ToppCelldroplet-Liver-nan-3m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B CTH HMGCS2 PZP CFI

3.65e-06157665b72c6a1ed17bfc32d9dec193d934ea82e80b6bd5
ToppCellnormal_Lung-B_lymphocytes-MALT_B_cells|normal_Lung / Location, Cell class and cell subclass

IGKV2D-30 IGKV2D-29 IGKV2D-26 IGKV2-30 IGKV2-29

3.89e-06159665fbd0131b66f4267f7b0d6c3ad874ad097b859074
ToppCelldroplet-Liver-Hepatocytes-18m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B CTH HMGCS2 PZP CFI

4.01e-061606658de1fc75241d9bf2b355afa0e9ef39fea1977177
ToppCell368C-Lymphocytic-Plasma_cell-|368C / Donor, Lineage, Cell class and subclass (all cells)

IGKV2D-30 IGKV2D-29 IGKV2-30 IGKV2-29 IGKV2-24

4.26e-06162665c21a54310b239d999bbc9d8fb5e8fda16e0bc336
ToppCell368C-Lymphocytic-Plasma_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

IGKV2D-30 IGKV2D-29 IGKV2-30 IGKV2-29 IGKV2-24

4.26e-06162665f945688815229c8386cbcbf46deee7df316fa8d3
ToppCelldroplet-Liver-Hepatocytes|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B CTH HMGCS2 PZP CFI

4.39e-06163665a794540f2d8984f963c08f05175e4bc916fcc224
ToppCelldroplet-Liver-Hepatocytes-18m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B CTH HMGCS2 PZP CFI

4.39e-0616366503d9fa615d9d02ef98e20f28a10aaa6894dd4960
ToppCelldroplet-Liver-Hepatocytes-18m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B CTH HMGCS2 PZP CFI

4.39e-061636651c4de36cf8cdaabb981cda5c7ce7e5ae7b4280e3
ToppCelldroplet-Liver-Hepatocytes-18m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B CTH HMGCS2 PZP CFI

4.39e-061636657e82c1b7849eca895732df2da74ac6430bd9ba7a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC18A2 CD274 PZP ARHGEF6 HDC

4.52e-061646652c48c6e4eeee845f0563982d0bfa2a176ca5ef61
ToppCell367C-Lymphocytic-Plasma_cell-|367C / Donor, Lineage, Cell class and subclass (all cells)

IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2-30 IGKV2-29

4.94e-06167665f2185eb72f0137136f6d71af2a70168fded6c940
ToppCell367C-Lymphocytic-Plasma_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2-30 IGKV2-29

4.94e-061676655e768cf24699893e05d1bcb1c92dba2336943a64
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-4|TCGA-Liver / Sample_Type by Project: Shred V9

EPPK1 PGAP2 CPNE1 SFI1 MAP4K4

5.23e-061696650a3ba6b5d6cff9d3d7f56046063cfc3a37ae1156
ToppCelltumor_Lung-B_lymphocytes-Plasma_cells|tumor_Lung / Location, Cell class and cell subclass

IGKV2D-30 ST6GALNAC4 IGKV2D-29 IGKV2D-26 IGKV2-30

5.23e-06169665b36b7632ce55fc7b6b8b66020563d360b3de6fd7
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28 IGKV2-24

5.54e-0617166513126a3fbee181412c13ffb0c347277b9d8f16f7
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC18A2 PZP ADGRL2 ARHGEF6 HDC

5.70e-061726653a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC18A2 PZP ADGRL2 ARHGEF6 HDC

5.70e-06172665cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCellControl-Lymphoid-B_Plasma|Control / Disease state, Lineage and Cell class

IGKV2D-30 IGKV2D-29 IGKV2D-26 IGKV2-30 IGKV2-29

5.70e-0617266561e33836b8cb0f347f3e699eb587a37073b6fa4c
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGKV2D-40 IGKV2D-30 IGKV2-30 IGKV2-28 IGKV2-24

6.55e-061776654c434a7b7cc54cf4dac996bbc3f5124d9ef9a9cd
ToppCellVE-plasma|VE / Condition, Cell_class and T cell subcluster

IGKV2D-30 ST6GALNAC4 IGKV2D-28 IGKV2-30 IGKV2-24

6.55e-061776650c1cc0834de55717cb4f69d020339060ce2c9a03
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGKV2D-40 IGKV2D-30 IGKV2-30 IGKV2-28 IGKV2-24

6.55e-06177665d746122bf8d208c3aa4d156e8c12d0a0e555c6e5
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGKV2D-40 IGKV2D-30 IGKV2-30 IGKV2-28 IGKV2-24

6.55e-06177665fc40918825b7e1eb6861df59dfca944778a64b98
ToppCellVE-plasma-|VE / Condition, Cell_class and T cell subcluster

IGKV2D-30 ST6GALNAC4 IGKV2D-28 IGKV2-30 IGKV2-24

6.55e-061776653a3c94cf30012e2aa266bc4d7fe772e45fa90f6d
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV2D-40 IGKV2D-30 IGKV2-40 IGKV2-30 IGKV2-24

6.92e-06179665494febe77c6d4e6a2c6f0928bbf4c84b0301f188
ToppCellcellseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28 IGKV2-24

7.70e-061836655ab4aa0304b832f98fff89b6c24ad5b7dd014c11
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28 IGKV2-24

8.12e-0618566508bc817908076734d66f2805cb954141f2cc5a18
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28 IGKV2-24

8.12e-061856651704a12153a9b107bf03ecccd1a036cf61334d7a
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-28 IGKV2-24

8.78e-061886656844cebca177fdf38b21a40d606230a033717a3a
ToppCellASK452-Immune-Mast_cell|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

SLC18A2 CD274 ARHGEF6 PRNP HDC

8.78e-06188665840215e16cff90f821f776186284eafcf2350690
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYLK PAMR1 VCAN PRKG1 ADAMTSL2

9.01e-06189665c734e5693808a0333139e87bd5be2597a9252afe
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYLK PAMR1 VCAN PRKG1 ADAMTSL2

9.24e-061906652e592323085ba9c019d678ac2a784462ab470ed9
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGKV2D-29 IGKV2D-28 IGKV2-30 IGKV2-29 IGKV2-24

9.24e-0619066579ee6d10dfbb775da149a1104da5823cf63bbb46
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYLK PAMR1 VCAN PRKG1 ADAMTSL2

9.24e-06190665445952b70abffadb6ccc1ed4bbf61a88b06b73b3
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGKV2D-29 IGKV2D-28 IGKV2-30 IGKV2-29 IGKV2-24

9.24e-0619066518762ce78ed0b206ade19e1c8ff76a2647489f68
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYLK PAMR1 VCAN PRKG1 ADAMTSL2

9.48e-06191665c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-fibroblast|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAMR1 VCAN FGFR1 HMGCS2 HDC

9.48e-061916659214655dca96d766737c9f30b624d7fe7050342e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYLK PAMR1 VCAN PRKG1 ADAMTSL2

9.48e-06191665806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYLK PAMR1 VCAN PRKG1 ADAMTSL2

9.48e-06191665cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCellASK452-Immune-Mast_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

SLC18A2 CD274 ARHGEF6 PRNP HDC

9.72e-061926658269b88ff6073a908f547fcc7c5941f2e8289694
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PAMR1 VCAN FGFR1 HMGCS2 PRNP

9.72e-06192665011634a24b0c61d9b463fe755502edbc5cd70b7a
ToppCellCOVID_vent-Lymphocytic-Plasma_cell-IgM_Plasmablast|COVID_vent / Disease condition, Lineage, Cell class and subclass

IGKV2D-30 IGKV2D-29 IGKV2D-28 FGFR1 IGKV2-30

1.07e-05196665026a06d8d2089806823e6f6453d3ede84ae93bc6
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-B-B_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IGKV2D-30 IGKV2D-29 IGKV2D-28 IGKV2-29 IGKV2-28

1.10e-0519766576465bb2408c7c75f694e8f7cf1a606b796afc3a
ToppCellTracheal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC18A2 CD274 PZP ARHGEF6 HDC

1.13e-05198665cc5ca64749e2f4f1d373d9472824df85741702b7
ToppCellTracheal-NucSeq-Immune_Myeloid-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLC18A2 CD274 PZP ARHGEF6 HDC

1.13e-05198665d4d66f19df078bfc3a83d4664aaf9c7789bde1a5
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

MYLK PAMR1 VCAN PRKG1 PZP

1.18e-052006659d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

MYLK PAMR1 VCAN PRKG1 PZP

1.18e-052006655ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCellChildren_(3_yrs)-Immune-mast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC18A2 PZP ARHGEF6 HDC

6.56e-05146664f7349d63bb47f1f22ced8ff514edc1c11bc782e7
ToppCell10x5'-blood-Lymphocytic_B_plasma-Plasma_cells|blood / Manually curated celltypes from each tissue

IGKV2D-40 ST6GALNAC4 IGKV2-40 IGKV2-24

6.74e-0514766458089378fac1743ce99dc4f1bd7b5253a927f050
ToppCelldroplet-Liver-hepatocytes-3m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTH HMGCS2 PZP CFI

6.74e-0514766400619115b9a1ec2b967c2992043b41974ece63c4
ToppCell10x5'-blood-Lymphocytic_B_plasma|blood / Manually curated celltypes from each tissue

IGKV2D-40 ST6GALNAC4 IGKV2D-28 IGKV2-28

7.28e-051506646bab0a8bf78ed7de9e1b67ede7496488f80f4863
ToppCellAdult-Immune-mast_cell-D122|Adult / Lineage, Cell type, age group and donor

SLC18A2 PZP ARHGEF6 HDC

8.27e-051556647c9de0591d1bf756b8e268b278bbe10bd5415dcd
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC18A2 PZP ARHGEF6 HDC

8.27e-05155664231fbbbd6e6f9c86be7a15a9ec0804e6b9ab3b5f
ToppCellCOVID-19-Mast_cells-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

SLC18A2 PZP ARHGEF6 HDC

8.48e-05156664bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCellCOVID-19-Mast_cells|COVID-19 / group, cell type (main and fine annotations)

SLC18A2 PZP ARHGEF6 HDC

8.48e-05156664159504d43421ee83b9ab484816333ae549c9c2fd
ToppCellAdult-Immune-mast_cell-D231|Adult / Lineage, Cell type, age group and donor

SLC18A2 MOV10L1 CD274 HDC

8.69e-051576644c63bb91f8708644e6ce2500072a4eeb8e1079dd
ToppCellChildren_(3_yrs)-Immune-mast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC18A2 PZP ARHGEF6 HDC

8.69e-05157664ec185dbeabb67fd9ca85f71cab88463b60f9b1c1
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYLK PAMR1 VCAN GSDMC

9.35e-051606648624f101828efd32cdd38a65df8d94d690720a63
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYLK PAMR1 VCAN GSDMC

9.35e-051606649de3dd6b9d4b51314d60b3b01f4132bcfa2dfc18
ToppCellAdult-Immune-mast_cell|Adult / Lineage, Cell type, age group and donor

SLC18A2 PZP ARHGEF6 HDC

9.58e-0516166444f5c0256b3ce264a6c7b62740f32dcd45ee052d
ToppCellfacs-Trachea-18m-Hematologic-myeloid-granulocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC18A2 PPP1R3B CD274 HDC

9.58e-05161664d1f2e5245c7c247b684f48f9f877e149a3ee7c06
ToppCelldroplet-Liver-Hepatocytes-18m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTH HMGCS2 PZP CFI

9.58e-05161664274838cebdc7af1db32d309dfe42ef7ccd3c190b
ToppCell3'_v3-Lung-Lymphocytic_B_plasma-Plasma_cells|Lung / Manually curated celltypes from each tissue

IGKV2D-29 IGKV2-30 IGKV2-29 IGKV2-24

1.03e-041646643b6a32ba53d05f6818fe950ac426f489383b645a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RALBP1 HMGCS2 PRKG1 ADGRL2

1.03e-041646646fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PPP1R3B GCK HMGCS2 CFI

1.05e-04165664d449a568664a81d9b5538e8f409301448a32ac37
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLC18A2 PZP ARHGEF6 HDC

1.05e-0416566437615622c736e43260c38016e7c9e565ac97a3e8
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLC18A2 PZP ARHGEF6 HDC

1.05e-04165664640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLC18A2 PZP ARHGEF6 HDC

1.05e-04165664f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCellfacs-Trachea-nan-18m-Myeloid-granulocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC18A2 PPP1R3B CD274 HDC

1.08e-041666647f8b4cf63c3e292ae421f111edaa4572717f4db1
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC18A2 ARHGEF6 FERMT3 HDC

1.10e-04167664a813b95c2fafb638b249bc4fa4f708c6f39ad444
ToppCellBAL-Mild-Lymphocyte-B|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGKV2D-30 IGKV2D-28 IGKV2-30 IGKV2-29

1.15e-04169664307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGKV2D-30 ST6GALNAC4 IGKV2D-28 IGKV2-30

1.15e-041696640c2384f780ec25710ebb35c0b0df8f4afb53c9b1
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

SLC18A2 PZP ARHGEF6 HDC

1.15e-04169664fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCellCOVID-19-lung-MAST|lung / Disease (COVID-19 only), tissue and cell type

SLC18A2 PZP ARHGEF6 HDC

1.18e-04170664e90f18e5462381b38e918442b38b1c8105291908
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

SLC18A2 PZP ARHGEF6 HDC

1.18e-04170664c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell10x5'-Lung-Lymphocytic_B_plasma|Lung / Manually curated celltypes from each tissue

IGKV2D-40 ST6GALNAC4 IGKV2D-29 IGKV2-40

1.24e-041726648156fb6de66a4c92ade703b71c2e9187291e50ef
ToppCellImmune-mast_cell|World / Lineage, Cell type, age group and donor

SLC18A2 PZP ARHGEF6 HDC

1.24e-041726646e8e0aac5a20dbc789bf8c6916833bb8709a411a
ToppCellwk_08-11-Hematologic_Lymphocytic-B|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

IGKV2D-30 IGKV2D-26 IGKV2-30 IGKV2-29

1.24e-04172664d1ab8f493b70ec995281f9fb0991f1d3aa7b928f
ToppCellnormal-na-Hematopoietic-Progen-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

JAK1 FNDC7 SLC18A2 RPL5

1.26e-04173664e666364eb110c1c976e5b09a632dd1454513f131
ToppCellLeuk-UTI-Myeloid-cDC1|Leuk-UTI / Disease, Lineage and Cell Type

MYLK PIK3CB TP53RK CFI

1.26e-04173664226bb8d881f32d65c60f5e4c034c6d465f8e7ba5
Drug15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A

EVI5 PIK3CB ATP2C2 LSS ST6GALNAC4 CTH MAPK8IP3

4.45e-071925677526_UP
DiseaseNeoplasm of uncertain or unknown behavior of breast

PIK3CB FGFR1 HERC2

8.47e-0541613C0496956
DiseaseBreast adenocarcinoma

PIK3CB FGFR1 HERC2

8.47e-0541613C0858252
Diseasefornix volume measurement

EVI5 RPL5

8.77e-057612EFO_0803381
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

MYLK VCAN PRKG1

1.83e-0453613C4707243
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

MYLK PRKG1

1.87e-0410612cv:C4707243
DiseaseHead and Neck Carcinoma

PIK3CB FGFR1

1.87e-0410612C3887461
Diseasethoracic aortic aneurysm (is_implicated_in)

MYLK PRKG1

2.28e-0411612DOID:14004 (is_implicated_in)
DiseaseT-cell acute lymphoblastic leukemia (is_implicated_in)

JAK1 RPL5

2.28e-0411612DOID:5603 (is_implicated_in)
Diseasepancreatic adenocarcinoma (is_implicated_in)

JAK1 RALBP1

4.34e-0415612DOID:4074 (is_implicated_in)
Diseasehyperglycemia (implicated_via_orthology)

GCK PRNP

5.60e-0417612DOID:4195 (implicated_via_orthology)
Diseaselung adenocarcinoma (is_marker_for)

SRSF1 EHMT2 MAP4K4

7.36e-0485613DOID:3910 (is_marker_for)
DiseaseNeoplasm Metastasis

SRSF1 MYLK EHMT2 PRNP

1.07e-03217614C0027627
Diseaseglioblastoma (is_implicated_in)

PIK3CB RPL5

1.13e-0324612DOID:3068 (is_implicated_in)
DiseaseHeart valve disease

FGFR1 ADAMTSL2

1.32e-0326612C0018824
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

PIK3CB GCK OGA

1.36e-03105613DOID:9352 (implicated_via_orthology)
Diseaseglucose metabolism disease (implicated_via_orthology)

PIK3CB GCK

1.53e-0328612DOID:4194 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
YYSQLKTVCVEMGDV

ALDH9A1

476

P49189
RRTMGYQDFADVVCY

CFI

201

P05156
VMVQYGACEEKEERY

ARHGEF6

456

Q15052
GLYRCDVMYGIEDTQ

VCAN

126

P13611
EYEISEMVGYCAARS

GSDMC

241

Q9BYG8
QIICMDDVYGGTNRY

CTH

106

P32929
MICGVLYVVRSVYQD

ADGRL2

316

O95490
YMVQRGGCVYSKEED

EHMT2

736

Q96KQ7
GALEEVIRYCTMYNN

ATP2C2

511

O75185
AVFRECIDYVEKYGM

RALBP1

211

Q15311
MDEKVNITVCGEYTY

PZP

241

P20742
DLYVVEYGSNMTIEC

CD274

26

Q9NZQ7
ARNMEVYLGEEYCGT

PAAT

96

Q9H8K7
MIRNEDGQICFVEYY

RAD1

256

O60671
VYLYGVCVRDVENIM

JAK1

651

P23458
ISCYYEDHQCEVGMI

GCK

211

P35557
HVYCEGNDVYDVMLN

PARP2

106

Q9UGN5
SRVEAEDVGVYYCMQ

IGKV2D-29

101

A0A075B6S2
GREMVDYICQYLSTV

HDC

11

P19113
MYCEAGVYTIFAILE

PGAP2

206

Q9UHJ9
MELLVCYEDEGVYVN

MAP4K4

1131

O95819
ISRVEAEDVGVYYCM

IGKV2D-40

101

P01614
AEDVGVYYCMQRIEF

IGKV2D-40

106

P01614
SRVEAEDVGVYYCMQ

IGKV2D-30

101

A0A075B6S6
ECIKYMRQISEGVEY

MYLK

1561

Q15746
RGVVTRYCSDYGMID

MOV10L1

41

Q9BXT6
GVVVYQDDYCSGSVM

MAPK8IP3

11

Q9UPT6
DDYAVYVRENIQVGM

HERC2

2561

O95714
YETKAVDGYNMVECN

FNDC7

401

Q5VTL7
QIQEIVDCMYPVEYG

PRKG1

111

Q13976
SRVEAEDVGVYYCMQ

IGKV2D-28

101

P01615
DGRYAMVVCGDIAVY

HMGCS2

186

P54868
SRVEAEDFGVYYCMQ

IGKV2D-26

101

A0A0A0MRZ7
MKAYSLVDREVGYCQ

EVI5

231

O60447
GRTYADYESVNECME

ERH

16

P84090
IDYTYVECTSAVMQA

LSS

526

P48449
SAYAMCVRYDGVEVD

ADAMTSL2

586

Q86TH1
AVMAYDRYVAVCDAL

OR2F1

116

Q13607
GYEIYDTCTEVTVAM

GPRC6A

96

Q5T6X5
TYYTVRMFLDQCVDG

EBLN1

236

P0CF75
VSCAYQVARGMEYLA

FGFR1

601

P11362
QCYMDTEQYEEAVRD

DNAJC7

336

Q99615
SRVEAEDVGVYYCMQ

IGKV2-24

101

A0A0C4DH68
SRVEAEDVGVYYCMQ

IGKV2-28

101

A0A075B6P5
SRVEAEDVGVYYCMQ

IGKV2-29

101

A2NJV5
SRVEAEDVGVYYCMQ

IGKV2-30

101

P06310
ISRVEAEDVGVYYCM

IGKV2-40

101

A0A087WW87
AEDVGVYYCMQRIEF

IGKV2-40

106

A0A087WW87
CRVETEYSFLDYVMG

CPNE1

266

Q99829
ERMEFAVYYECNGQT

PPP1R3B

206

Q86XI6
MCQYDYVEVRDGDNR

PAMR1

176

Q6UXH9
EAVSVQMYYRQQEDC

SFI1

726

A8K8P3
ASVYKICREMYDDGV

OGA

726

O60502
VDVAYRCGYFDEEMN

EPPK1

1701

P58107
YARIEGDMIVCAAYA

RPL5

66

P46777
MIATGCEDTNVRVYY

WDR17

536

Q8IZU2
DQYVREYAVGCLRQM

PIK3CB

616

P42338
EEIVVYGMVSDSYCR

ST6GALNAC4

226

Q9H4F1
VETVVNMGYSYECVL

UBAP1

396

Q9NZ09
VSVYARAYLCRVGME

VPS35L

331

Q7Z3J2
VNEVVRYEAGYVVCA

PROM2

96

Q8N271
VIMQDYERVVAYHCQ

VPS18

561

Q9P253
EQMCITQYERESQAY

PRNP

211

P04156
GMSEIYLRCQDEQQY

FERMT3

431

Q86UX7
YASNCLYMEEIEGSV

TP53RK

106

Q96S44
MREAGDVCYADVYRD

SRSF1

141

Q07955
VYAIADVAFCMGYAI

SLC18A2

421

Q05940
QEMCETAVEYAPDYQ

ZFC3H1

1421

O60293
TDFYGEYVMQENCGI

ZNF641

131

Q96N77