Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR51G2 OR2W3 TAS2R42 VN1R5 OR8D1 OR2M7 ACKR3 OR4E1 OR2Y1 VN1R17P OR2A25 OR2M5 OR2M3 OR56A4 PTAFR OR10S1 OR6X1 ADGRG6 GNRHR2	4.28e-10	884	75	19	GO:0004930
GeneOntologyMolecularFunction	olfactory receptor activity	OR51G2 OR2W3 OR8D1 OR2M7 OR4E1 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	6.71e-08	431	75	12	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR51G2 OR2W3 TAS2R42 VN1R5 OR8D1 OR2M7 ACKR3 OR4E1 OR2Y1 VN1R17P OR2A25 OR2M5 OR2M3 OR56A4 PTAFR OR10S1 OR6X1 ADGRG6 GNRHR2	4.02e-07	1353	75	19	GO:0004888
GeneOntologyMolecularFunction	pheromone receptor activity	VN1R5 VN1R17P	2.07e-04	6	75	2	GO:0016503
GeneOntologyBiologicalProcess	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PCDHB14 PCDHB13 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	7.73e-10	53	74	7	GO:0016339
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR51G2 OR2W3 TAS2R42 VN1R5 OR8D1 OR2M7 OR4E1 OR2Y1 VN1R17P OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	8.06e-10	547	74	15	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR51G2 OR2W3 TAS2R42 OR8D1 OR2M7 OR4E1 OR2Y1 OR2A25 OR2M5 KCNMB3 OR2M3 OR56A4 OR10S1 OR6X1	4.43e-09	524	74	14	GO:0009593
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR51G2 OR2W3 TAS2R42 OR8D1 OR2M7 OR4E1 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	1.62e-08	485	74	13	GO:0050907
GeneOntologyBiologicalProcess	homophilic cell adhesion via plasma membrane adhesion molecules	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	2.27e-08	187	74	9	GO:0007156
GeneOntologyBiologicalProcess	sensory perception	OR51G2 OR2W3 CLN8 TAS2R42 VN1R5 OR8D1 OR2M7 WFS1 OR4E1 OR2Y1 CLN6 VN1R17P OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	3.03e-08	1072	74	18	GO:0007600
GeneOntologyBiologicalProcess	detection of stimulus	OR51G2 OR2W3 TAS2R42 OR8D1 OR2M7 TRPC3 OR4E1 OR2Y1 OR2A25 OR2M5 KCNMB3 OR2M3 OR56A4 OR10S1 OR6X1	3.36e-08	722	74	15	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR51G2 OR2W3 OR8D1 OR2M7 OR4E1 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	4.15e-08	432	74	12	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR51G2 OR2W3 OR8D1 OR2M7 OR4E1 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	9.26e-08	465	74	12	GO:0007608
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR51G2 OR2W3 TAS2R42 OR8D1 OR2M7 OR4E1 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	1.36e-07	582	74	13	GO:0050906
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR51G2 OR2W3 TAS2R42 VN1R5 OR8D1 OR2M7 ACKR3 OR4E1 OR2Y1 VN1R17P OR2A25 OR2M5 OR2M3 OR56A4 PTAFR OR10S1 OR6X1 ADGRG6 GNRHR2	3.12e-07	1395	74	19	GO:0007186
GeneOntologyBiologicalProcess	cell-cell adhesion via plasma-membrane adhesion molecules	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.77e-06	313	74	9	GO:0098742
GeneOntologyBiologicalProcess	synapse assembly	PCDHB14 PCDHB13 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.18e-04	308	74	7	GO:0007416
GeneOntologyCellularComponent	endoplasmic reticulum membrane	PIGN CLN8 ZDHHC20 CLPTM1L SLC8A3 OR2M7 TMEM203 CYP2D6 SLC37A3 WFS1 OR4E1 CLN6 OR2A25 OR2M5 OR2M3 TMEM35A HAS2 ALG6 ADGRG6	1.24e-07	1293	76	19	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	PIGN CLN8 ZDHHC20 CLPTM1L SLC8A3 OR2M7 TMEM203 CYP2D6 SLC37A3 WFS1 OR4E1 CLN6 OR2A25 OR2M5 OR2M3 TMEM35A HAS2 ALG6 ADGRG6	1.33e-07	1299	76	19	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	PIGN CLN8 ZDHHC20 CLPTM1L SLC8A3 OR2M7 TMEM203 CYP2D6 SLC37A3 WFS1 OR4E1 CLN6 OR2A25 OR2M5 OR2M3 TMEM35A HAS2 ALG6 ADGRG6	1.85e-07	1327	76	19	GO:0042175
Domain	Cadherin_C_2	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	3.09e-12	42	71	8	PF16492
Domain	Cadherin_C	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	3.09e-12	42	71	8	IPR032455
Domain	Cadherin_N	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.23e-10	65	71	8	IPR013164
Domain	Cadherin_2	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.23e-10	65	71	8	PF08266
Domain	G_PROTEIN_RECEP_F1_2	OR51G2 OR2W3 TAS2R42 VN1R5 OR8D1 OR2M7 ACKR3 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 PTAFR OR10S1 OR6X1 GNRHR2	4.98e-09	691	71	16	PS50262
Domain	GPCR_Rhodpsn	OR51G2 OR2W3 TAS2R42 VN1R5 OR8D1 OR2M7 ACKR3 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 PTAFR OR10S1 OR6X1 GNRHR2	5.09e-09	692	71	16	IPR000276
Domain	Cadherin_CS	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	8.14e-09	109	71	8	IPR020894
Domain	Cadherin	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.08e-08	113	71	8	PF00028
Domain	CADHERIN_1	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.08e-08	113	71	8	PS00232
Domain	CADHERIN_2	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.16e-08	114	71	8	PS50268
Domain	-	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.16e-08	114	71	8	2.60.40.60
Domain	CA	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.24e-08	115	71	8	SM00112
Domain	Cadherin-like	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.33e-08	116	71	8	IPR015919
Domain	Cadherin	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.52e-08	118	71	8	IPR002126
Domain	G_PROTEIN_RECEP_F1_1	OR51G2 OR2W3 VN1R5 OR8D1 OR2M7 ACKR3 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 PTAFR OR10S1 OR6X1 GNRHR2	3.40e-08	685	71	15	PS00237
Domain	GPCR_Rhodpsn_7TM	OR51G2 OR2W3 TAS2R42 OR8D1 OR2M7 ACKR3 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 PTAFR OR10S1 OR6X1	1.85e-07	670	71	14	IPR017452
Domain	7tm_1	OR51G2 OR2W3 OR8D1 OR2M7 ACKR3 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 PTAFR OR10S1 OR6X1 GNRHR2	2.10e-07	677	71	14	PF00001
Domain	Olfact_rcpt	OR51G2 OR2W3 OR8D1 OR2M7 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	2.57e-07	393	71	11	IPR000725
Domain	PCDHB2/3	PCDHB3 PCDHB2	1.42e-05	2	71	2	IPR030735
Domain	DUF846	TVP23C TVP23B	8.51e-05	4	71	2	PF05832
Domain	DUF846_euk	TVP23C TVP23B	8.51e-05	4	71	2	IPR008564
Domain	TRP_dom	TRPC3 TRPC4	2.12e-04	6	71	2	IPR013555
Domain	TRP_2	TRPC3 TRPC4	2.12e-04	6	71	2	PF08344
Domain	Alkaline_phosphatase_core	ARSH PIGN ARSF	2.19e-04	31	71	3	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSH PIGN ARSF	2.19e-04	31	71	3	IPR017849
Domain	-	ARSH PIGN ARSF	2.19e-04	31	71	3	3.40.720.10
Domain	TRPC_channel	TRPC3 TRPC4	2.96e-04	7	71	2	IPR002153
Domain	TRP_channel	TRPC3 TRPC4	7.66e-04	11	71	2	IPR004729
Domain	Sulfatase_CS	ARSH ARSF	1.65e-03	16	71	2	IPR024607
Domain	SULFATASE_1	ARSH ARSF	1.87e-03	17	71	2	PS00523
Domain	SULFATASE_2	ARSH ARSF	1.87e-03	17	71	2	PS00149
Domain	Sulfatase	ARSH ARSF	2.10e-03	18	71	2	PF00884
Domain	Sulfatase_N	ARSH ARSF	2.10e-03	18	71	2	IPR000917
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR51G2 OR2W3 OR8D1 OR2M7 OR4E1 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	7.85e-09	417	47	12	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR51G2 OR2W3 OR8D1 OR2M7 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	4.38e-08	389	47	11	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	OR51G2 OR2W3 OR8D1 OR2M7 MYO1C OR4E1 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	9.68e-08	636	47	13	M41834
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2W3 OR8D1 OR56A4 OR10S1	8.46e-05	70	47	4	MM14984
Pathway	WP_GPCRS_OTHER	VN1R5 OR8D1 OR2Y1 VN1R17P	2.88e-04	96	47	4	MM15939
Pathway	REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN_1_SIGNALING	TRPC3 TRPC4	4.81e-04	10	47	2	M27330
Pathway	REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES	ARSH ARSF	8.29e-04	13	47	2	M663
Pathway	WP_CODEINE_AND_MORPHINE_METABOLISM	ABCC3 CYP2D6	9.65e-04	14	47	2	M39328
Pathway	BIOCARTA_RACC_PATHWAY	TRPC3 TRPC4	1.11e-03	15	47	2	M22002
Pubmed	The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.15e-19	20	76	9	11322959
Pubmed	Protocadherins.	PCDHB14 PCDHB13 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	3.04e-16	13	76	7	12231349
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	5.75e-15	57	76	9	32633719
Pubmed	CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons.	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	6.80e-15	58	76	9	30377227
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	3.09e-14	68	76	9	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	5.30e-14	72	76	9	10380929
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	6.86e-14	74	76	9	10817752
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	9.97e-14	77	76	9	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.43e-13	80	76	9	10716726
Pubmed	Single-neuron diversity generated by Protocadherin-β cluster in mouse central and peripheral nervous systems.	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3	1.09e-11	10	76	5	22969705
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR51G2 OR2W3 OR8D1 OR2M7 OR4E1 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	1.11e-11	340	76	12	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR51G2 OR2W3 OR8D1 OR2M7 OR4E1 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	1.11e-11	340	76	12	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR51G2 OR2W3 OR8D1 OR2M7 OR4E1 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	1.23e-11	343	76	12	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR51G2 OR2W3 OR8D1 OR2M7 OR4E1 OR2Y1 OR2A25 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	1.36e-11	346	76	12	14611657
Pubmed	A unique role of cohesin-SA1 in gene regulation and development.	PCDHB18P PCDHB14 PCDHB13 PCDHB8 PCDHB16	1.87e-10	16	76	5	22415368
Pubmed	Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system.	PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3	2.64e-10	17	76	5	18279309
Pubmed	Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.	PCDHB18P PCDHB14 PCDHB13 PCDHB8 PCDHB16	4.95e-10	19	76	5	23920377
Pubmed	Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice.	PCDHB13 PCDHB8 PCDHB3 PCDHB2 PCDHB16	4.12e-09	28	76	5	33523829
Pubmed	The human olfactory receptor gene family.	OR51G2 OR2W3 OR8D1 OR2M7 OR4E1 OR2Y1 OR2M5 OR2M3 OR56A4 OR10S1 OR6X1	2.68e-08	541	76	11	14983052
Pubmed	High-throughput microarray detection of olfactory receptor gene expression in the mouse.	OR2M7 OR2M5 OR2M3	4.00e-08	4	76	3	15377787
Pubmed	Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes.	PCDHB18P PCDHB12 PCDHB11 PCDHB3 PCDHB16	1.99e-07	59	76	5	23754746
Pubmed	Identification of novel cadherins expressed in human melanoma cells.	PCDHB14 PCDHB11 PCDHB16	3.49e-07	7	76	3	9182820
Pubmed	Differential distribution of TRP Ca2+ channel isoforms in mouse brain.	TRPC3 TRPC4	4.71e-06	2	76	2	9512398
Pubmed	Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion.	VN1R5 VN1R17P	4.71e-06	2	76	2	11752409
Pubmed	A map of pheromone receptor activation in the mammalian brain.	VN1R5 VN1R17P	4.71e-06	2	76	2	10219242
Pubmed	Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system.	VN1R5 VN1R17P	4.71e-06	2	76	2	10219241
Pubmed	A multireceptor genetic approach uncovers an ordered integration of VNO sensory inputs in the accessory olfactory bulb.	VN1R5 VN1R17P	4.71e-06	2	76	2	16731509
Pubmed	TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells.	TRPC3 TRPC4	4.71e-06	2	76	2	16537542
Pubmed	A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer.	CLN8 CLN6	4.71e-06	2	76	2	32597833
Pubmed	Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes.	VN1R5 VN1R17P	4.71e-06	2	76	2	12214233
Pubmed	Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting.	PCDHB13 PCDHB8 PCDHB2	9.47e-06	19	76	3	28066179
Pubmed	Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho.	KL TRPC3	1.41e-05	3	76	2	27979597
Pubmed	Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse.	VN1R5 VN1R17P	1.41e-05	3	76	2	11116090
Pubmed	A common gene exclusion mechanism used by two chemosensory systems.	VN1R5 VN1R17P	1.41e-05	3	76	2	19200072
Pubmed	Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension.	TRPC3 TRPC4	1.41e-05	3	76	2	15358862
Pubmed	Molecular identification and localization of Trp homologues, putative calcium channels, in pregnant human uterus.	TRPC3 TRPC4	2.82e-05	4	76	2	12356946
Pubmed	Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes.	TRPC3 TRPC4	2.82e-05	4	76	2	15654973
Pubmed	Multiple new and isolated families within the mouse superfamily of V1r vomeronasal receptors.	VN1R5 VN1R17P	2.82e-05	4	76	2	11802169
Pubmed	Formation of novel TRPC channels by complex subunit interactions in embryonic brain.	TRPC3 TRPC4	4.69e-05	5	76	2	12857742
Pubmed	Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli.	TRPC3 TRPC4	4.69e-05	5	76	2	15611229
Pubmed	Enhanced capacitative calcium entry and TRPC channel gene expression in human LES smooth muscle.	TRPC3 TRPC4	4.69e-05	5	76	2	12736151
Pubmed	CLN3p impacts galactosylceramide transport, raft morphology, and lipid content.	CLN8 CLN6	4.69e-05	5	76	2	18317235
Pubmed	Neuronal ceroid lipofuscinosis: a common pathway?	CLN8 CLN6	4.69e-05	5	76	2	17237713
Pubmed	Convergence of FPR-rs3-expressing neurons in the mouse accessory olfactory bulb.	VN1R5 VN1R17P	4.69e-05	5	76	2	23664818
Pubmed	TRPC3 channels are required for synaptic transmission and motor coordination.	TRPC3 TRPC4	4.69e-05	5	76	2	18701065
Pubmed	Calcium Channels Formed by Mammalian Trp Homologues.	TRPC3 TRPC4	7.03e-05	6	76	2	11390792
Pubmed	trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.	TRPC3 TRPC4	7.03e-05	6	76	2	8646775
Pubmed	Batten's disease: clues to neuronal protein catabolism in lysosomes.	CLN8 CLN6	7.03e-05	6	76	2	10740217
Pubmed	Disrupted compartmental organization of axons and dendrites within olfactory glomeruli of mice deficient in the olfactory cell adhesion molecule, OCAM.	VN1R5 VN1R17P	7.03e-05	6	76	2	16531066
Pubmed	Axonal wiring of guanylate cyclase-D-expressing olfactory neurons is dependent on neuropilin 2 and semaphorin 3F.	VN1R5 VN1R17P	7.03e-05	6	76	2	17942483
Pubmed	Transient receptor potential channels and their role in modulating radial glial-neuronal interaction: a signaling pathway involving mGluR5.	TRPC3 TRPC4	7.03e-05	6	76	2	25347706
Pubmed	Mutations in CLN7/MFSD8 are a common cause of variant late-infantile neuronal ceroid lipofuscinosis.	CLN8 CLN6	7.03e-05	6	76	2	19201763
Pubmed	TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.	TRPC3 TRPC4	7.03e-05	6	76	2	32414784
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	SLC8A3 TRPC3 TRPC4	8.01e-05	38	76	3	30786075
Pubmed	MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.	TRPC3 TRPC4	9.83e-05	7	76	2	15757897
Pubmed	Mechanism of stretch-induced activation of the mechanotransducer zyxin in vascular cells.	TRPC3 TRPC4	9.83e-05	7	76	2	23233529
Pubmed	RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways.	TRPC3 TRPC4	9.83e-05	7	76	2	32350291
Pubmed	TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis.	TRPC3 TRPC4	9.83e-05	7	76	2	36592529
Pubmed	Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models.	TRPC3 TRPC4	9.83e-05	7	76	2	15336983
Pubmed	TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.	TRPC3 TRPC4	9.83e-05	7	76	2	38835669
Pubmed	Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors.	VN1R5 VN1R17P	9.83e-05	7	76	2	19387439
Pubmed	Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes.	TRPC3 TRPC4	9.83e-05	7	76	2	36257322
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR2W3 OR4E1 OR2Y1 OR2M3 OR10S1	1.21e-04	219	76	5	12213199
Pubmed	Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins.	CLN8 CLN6	1.31e-04	8	76	2	19941651
Pubmed	Subunit composition of mammalian transient receptor potential channels in living cells.	TRPC3 TRPC4	1.31e-04	8	76	2	12032305
Pubmed	Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels.	TRPC3 TRPC4	1.31e-04	8	76	2	25471572
Pubmed	Association of immunophilins with mammalian TRPC channels.	TRPC3 TRPC4	1.31e-04	8	76	2	15199065
Pubmed	Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.	TRPC3 TRPC4	1.68e-04	9	76	2	14505576
Pubmed	Adenylyl cyclase-dependent axonal targeting in the olfactory system.	VN1R5 VN1R17P	1.68e-04	9	76	2	17537788
Pubmed	Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.	VN1R5 VN1R17P	1.68e-04	9	76	2	36383665
Pubmed	An Optimized Preparation Method for Long ssDNA Donors to Facilitate Quick Knock-In Mouse Generation.	PCDHB12 PCDHB11	1.68e-04	9	76	2	33946570
Pubmed	Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.	TRPC3 TRPC4	1.68e-04	9	76	2	11290752
Pubmed	Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion.	TRPC3 TRPC4	1.68e-04	9	76	2	17480026
Pubmed	Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease.	CLN8 CLN6	1.68e-04	9	76	2	15647513
Pubmed	Heterogeneous distribution of TRPC proteins in the embryonic cortex.	TRPC3 TRPC4	2.10e-04	10	76	2	18989690
Pubmed	The leak channel NALCN controls tonic firing and glycolytic sensitivity of substantia nigra pars reticulata neurons.	TRPC3 TRPC4	2.10e-04	10	76	2	27177420
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	ZDHHC20 CLPTM1L TMEM161A MYO1C WFS1 TVP23C TVP23B ALG6 STEAP1	2.29e-04	952	76	9	38569033
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	PIGN ABCC3 CLPTM1L TMEM161A ATR WFS1 ACKR3 CLN6 ALG6 KIAA2013	2.80e-04	1201	76	10	35696571
Pubmed	Neuronal Ceroid-Lipofuscinoses – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	CLN8 CLN6	3.62e-04	13	76	2	20301601
Pubmed	Meiotic failure in male mice lacking an X-linked factor.	ATR MSH4	3.62e-04	13	76	2	18316482
Pubmed	Melanopsin signalling in mammalian iris and retina.	TRPC3 TRPC4	3.62e-04	13	76	2	22051675
Pubmed	Retinal degeneration mutants in the mouse.	CLN8 CLN6	3.62e-04	13	76	2	11853768
Pubmed	Evolution of odorant receptors expressed in mammalian testes.	OR8D1 OR2Y1	3.62e-04	13	76	2	11014824
Pubmed	MEIOB targets single-strand DNA and is necessary for meiotic recombination.	ATR MEIOB	4.22e-04	14	76	2	24068956
Pubmed	Retinoic acid selectively inhibits death of basal vomeronasal neurons during late stage of neural circuit formation.	VN1R5 VN1R17P	4.22e-04	14	76	2	19519663
Pubmed	Neuronal ceroid lipofuscinosis (nclf), a new disorder of the mouse linked to chromosome 9.	CLN8 CLN6	4.22e-04	14	76	2	9600738
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR2W3 OR4E1 OR2Y1	5.81e-04	74	76	3	15081110
Pubmed	Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.	TRPC3 TRPC4	6.27e-04	17	76	2	22411552
Pubmed	The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map.	OR4E1 OR2Y1	7.05e-04	18	76	2	26446231
Pubmed	Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.	ATR MSH4	7.87e-04	19	76	2	21478856
Pubmed	A developmental lineage-based gene co-expression network for mouse pancreatic β-cells reveals a role for Zfp800 in pancreas development.	PCDHB13 PCDHB8	9.63e-04	21	76	2	33653874
Pubmed	Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.	TRPC3 TRPC4	9.63e-04	21	76	2	30270038
Pubmed	Defining the membrane proteome of NK cells.	PIGN ZDHHC20 CLPTM1L BTN3A3 MYO1C CLN6 ALG6 KIAA2013 STEAP1	9.98e-04	1168	76	9	19946888
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPC3 TRPC4	1.26e-03	24	76	2	33884443
Pubmed	Genetic mapping of mouse transient receptor potential (Trrp) genes responsible for capacitative calcium entry channels to chromosomes 3, 7, 9, and X.	TRPC3 TRPC4	1.26e-03	24	76	2	9722956
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPC3 TRPC4	1.37e-03	25	76	2	16382100
Pubmed	Delineating the early transcriptional specification of the mammalian trachea and esophagus.	ACKR3 HAS2	1.37e-03	25	76	2	32515350
Pubmed	Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome.	VN1R5 VN1R17P	1.37e-03	25	76	2	20003482
Pubmed	Bcl11b/Ctip2 controls the differentiation of vomeronasal sensory neurons in mice.	VN1R5 VN1R17P	1.48e-03	26	76	2	21752992
Pubmed	Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.	VN1R5 VN1R17P	1.97e-03	30	76	2	17273929
Interaction	PCDHB3 interactions	PCDHB18P PCDHB13 PCDHB8 PCDHB3 PCDHB2 CLN6 PCDHB16 KIAA2013 ADGRG6	9.41e-10	141	67	9	int:PCDHB3
Interaction	PCDHB13 interactions	PCDHB13 PCDHB11 PCDHB3	3.50e-07	5	67	3	int:PCDHB13
Interaction	SPPL2B interactions	PIGN CLPTM1L TMEM161A SLC8A3 CMTM4 TVP23C CLN6 KIAA2013	1.03e-06	233	67	8	int:SPPL2B
Interaction	PCDHB18P interactions	PCDHB18P PCDHB3	1.09e-05	2	67	2	int:PCDHB18P
Interaction	PCDHB8 interactions	PCDHB8 PCDHB3	6.50e-05	4	67	2	int:PCDHB8
Interaction	ATP2A3 interactions	CLPTM1L TMEM161A PCDHB11 TVP23C KCNMB3 PCDHB16	1.21e-04	232	67	6	int:ATP2A3
Interaction	C5AR1 interactions	TMEM161A WFS1 CMTM4 TVP23C KIAA2013	1.61e-04	154	67	5	int:C5AR1
Cytoband	5q31	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	3.49e-13	115	76	9	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	1.77e-09	298	76	9	chr5q31
Cytoband	1q44	OR2W3 VN1R5 OR2M7 VN1R17P OR2M5 OR2M3	3.14e-08	110	76	6	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2W3 VN1R5 OR2M7 VN1R17P OR2M5 OR2M3	7.78e-08	128	76	6	chr1q44
Cytoband	11q24.1	OR10S1 OR6X1	1.73e-03	37	76	2	11q24.1
Cytoband	3q23	ATR PXYLP1	2.45e-03	44	76	2	3q23
Cytoband	Ensembl 112 genes in cytogenetic band chr11q24	OR8D1 OR10S1 OR6X1	3.99e-03	191	76	3	chr11q24
Cytoband	Ensembl 112 genes in cytogenetic band chr3q23	ATR PXYLP1	4.95e-03	63	76	2	chr3q23
GeneFamily	Clustered protocadherins	PCDHB18P PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3 PCDHB2 PCDHB16	3.83e-13	64	57	9	20
GeneFamily	Olfactory receptors, family 2	OR2W3 OR2M7 OR2Y1 OR2A25 OR2M5 OR2M3	1.46e-06	113	57	6	149
GeneFamily	Sulfatases	ARSH ARSF	1.45e-03	18	57	2	410
GeneFamily	Transient receptor potential cation channels	TRPC3 TRPC4	3.50e-03	28	57	2	249
GeneFamily	Solute carriers	SLC26A8 SLC8A3 SLC37A3 SLC15A5 SLC44A3	8.01e-03	395	57	5	752
Coexpression	MIKKELSEN_ES_HCP_WITH_H3K27ME3	PCDHB18P PCDHB14 PCDHB12 PCDHB11 PCDHB16	1.07e-07	42	72	5	MM1275
Coexpression	FIGUEROA_AML_METHYLATION_CLUSTER_3_UP	PCDHB18P SLC8A3 PCDHB14 PCDHB11 PCDHB8 PCDHB16 ADGRG6	4.41e-07	170	72	7	M2168
Coexpression	MIKKELSEN_ES_HCP_WITH_H3K27ME3	PCDHB18P PCDHB14 PCDHB12 PCDHB16	4.91e-06	41	72	4	M2000
CoexpressionAtlas	PP_RBC_top-relative-expression-ranked_2500_k-means-cluster#3	PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB8 PCDHB3	7.39e-06	158	63	6	PP_RBC_2500_K3
CoexpressionAtlas	DevelopingKidney_e15.5_Medullary collecting duct_emap-28063_k-means-cluster#1_top-relative-expression-ranked_1000	PIGN ABCC3 ACKR3 SLC44A3 TMEM117 ADGRG6	5.44e-05	225	63	6	gudmap_developingKidney_e15.5_Medullary collecting duct_1000_k1
CoexpressionAtlas	DevelopingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_emap-3087_k-means-cluster#1_top-relative-expression-ranked_1000	PCDHB13 PCDHB12 PCDHB11 PCDHB3 PXYLP1 PCDHB16	5.99e-05	229	63	6	gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr mesench_1000_k1
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	B3GALT2 PCDHB12 PCDHB2 HAS2 STEAP1	1.77e-05	191	75	5	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	B3GALT2 PCDHB12 PCDHB2 HAS2 STEAP1	1.77e-05	191	75	5	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SERPINB11 SIDT1 EMP2 TMEM117 ADGRG6	1.87e-05	193	75	5	a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocye.Tnr.Pdgfa_(Pdgfa)\|Striatum / BrainAtlas - Mouse McCarroll V32	PCDHB2 SLC15A5 HAS2 STEAP1	2.28e-05	98	75	4	26250ea4171a0557a67505839cf79d3fe4d9d41a
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr\|Striatum / BrainAtlas - Mouse McCarroll V32	PCDHB2 SLC15A5 HAS2 STEAP1	2.28e-05	98	75	4	42875d16ae9fcbaf988cd71be82568f2f862f2dd
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_2\|Striatum / BrainAtlas - Mouse McCarroll V32	PCDHB2 SLC15A5 HAS2 STEAP1	2.28e-05	98	75	4	7a62a77ca83153dacff4d02d6e32104227d0980d
Disease	Neuronal ceroid lipofuscinosis	CLN8 CLN6	1.45e-04	9	60	2	cv:C0027877
Disease	nicotine dependence (implicated_via_orthology)	TRPC3 TRPC4	2.65e-04	12	60	2	DOID:0050742 (implicated_via_orthology)
Disease	lung cancer (is_implicated_in)	CLPTM1L ATR TRPC4	4.68e-04	74	60	3	DOID:1324 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ERHSKETFLLFFSFL	ARSF	276	P54793
FLLFFSFLHVHTPLI	ARSH	261	Q5FYA8
SLAFLLLNFHVSLFL	BTN3A3	6	O00478
FFLFSFQVHEKSILL	ALG6	336	Q9Y672
FEFRSLLHSQLATLF	COQ10B	186	Q9H8M1
IAVAVLLHFFLLATF	ADGRG6	931	Q86SQ4
IFAHSNTFIVFLFLL	ABCA13	3641	Q86UQ4
ALRQFTFVAFTHLLL	C17orf113	391	A0A1B0GUU1
FTTFYIHFALVLSAL	ABCC3	171	O15438
LASVSSLFLFSVLLF	PCDHB2	696	Q9Y5E7
LASVSSLFLFSVFLF	PCDHB18P	641	Q96TA0
LAAFFLGFLSALTHT	OR8D1	146	Q8WZ84
SHFILILFFSTVLLV	OR56A4	246	Q8NGH8
SLDFKSVFLSFHVLI	MEIOB	366	Q8N635
SVSSLFLFSVLLFVA	PCDHB13	696	Q9Y5F0
HSSLFFLLFLLIYSI	OR10S1	36	Q8NGN2
SPTHTFLFFLVLAIF	OR2M3	21	Q8NG83
SPTHTFLFFLVLAIF	OR2M5	21	A3KFT3
SPTHTFLFFLVLAIF	OR2M7	21	Q8NG81
FFLAHLSFLDLSFTT	OR2W3	61	Q7Z3T1
FFLSHLSLLDLCFTT	OR2Y1	61	Q8NGV0
LFFIHCFSFLESSVL	OR51G2	106	Q8NGK0
FHFFVGTTEFLILTI	OR6X1	101	Q8NH79
SVSSLFLFSVLLFVA	PCDHB12	696	Q9Y5F1
SVSSLFLFSVLLFVA	PCDHB11	696	Q9Y5F2
SVSSLFLFSVLLFVA	PCDHB16	696	Q9NRJ7
SVSSLFLFSVLLFVA	PCDHB14	696	Q9Y5E9
LSLVFLFAMFLFFNH	B3GALT2	31	O43825
AFIIAFHITSAALLF	EMP2	6	P54851
ASTFFSSFLELLKHL	ATR	266	Q13535
MELFLFFTSLLQHFS	CYP2D6	451	P10635
AFLASHLIIQSLFAF	HAS2	51	Q92819
HLIFSINLFGSIFFL	ACKR3	121	P25106
SSELGFHFVAFILLT	KCNMB3	6	Q9NPA1
FHTRKSLLAFIAFLF	KL	976	Q9UEF7
FTFRFITTLLVHIFI	SLC44A3	231	Q8N4M1
SLSFFALALSHKFVI	SDIM1	106	Q6ZPB5
FLHFLGTALLSVVAF	SLC15A5	116	A6NIM6
FLFLSFAHTECLLLV	OR2A25	101	A4D2G3
SVSSLFLFSVLLFVA	PCDHB3	696	Q9Y5E6
ASVSSLFLFSVLLFV	PCDHB8	696	Q9UN66
FLTSLLFLFLSLVRH	TAS2R42	196	Q7RTR8
HIFLFTVLLPSFTLT	ERVW-1	6	Q9UQF0
LQFLLHTSFLSPLFI	TMEM161A	266	Q9NX61
IIHIFIVFSFFLVFL	PTAFR	186	P25105
AFSLSLVSSFLLIFL	SLC26A8	361	Q96RN1
SFLLAFPQLFLFHTV	GNRHR2	76	Q96P88
STCILFFTLLFAHIA	MEP1A	6	Q16819
FSLLFSAVLSAHFRV	SHISAL1	16	Q3SXP7
LLSLKAFTLFATHFL	MSH4	781	O15457
LLAFVSLSLQFFHLI	PXYLP1	16	Q8TE99
FLFFIRHTHTNTILF	SERPINB11	371	Q96P15
LLSFFFAVLHAIYSL	STEAP1	166	Q9UHE8
FLFSSFALTLLLVAL	CLN6	261	Q9NWW5
VHLSNLIFRTFDLFL	CLN8	121	Q9UBY8
FLALTFFVAAFHLLF	CLPTM1L	286	Q96KA5
FLFFIASIVLAALNH	CMTM4	131	Q8IZR5
LTDTRAKFHVLFLFF	ZDHHC20	201	Q5W0Z9
ASFFHLFFRVSAIIV	TVP23C	36	Q96ET8
FFLHLFACTEIFLLT	OR4E1	106	P0C645
VVVFLLTFFSYSLLH	SLC37A3	21	Q8NCC5
FLSATALFFSFLVLL	SIDT1	796	Q9NXL6
FLALTSTALLFLLFF	TNFRSF9	191	Q07011
STALLFLLFFLTLRF	TNFRSF9	196	Q07011
SHLKLIELSFVFSFI	nan	176	Q1RN00
TLGLLIHFVFFASIF	PIGN	6	O95427
TFEIFVHLLALLVFS	TMEM203	16	Q969S6
TILLLFHIFTFVFSH	VN1R5	61	Q7Z5H4
SFGISANTFLLLFHI	VN1R17P	21	Q8TDU5
MFFSTILFLFIFSHI	TMEM117	111	Q9H0C3
ASFFHLFFRVSAIIV	TVP23B	36	Q9NYZ1
LSHLLTLVSKFEFVF	ZMYM1	846	Q5SVZ6
FICHTASYLTFLFLL	TRPC4	366	Q9UBN4
AHAASFIIFLGLLVF	TRPC3	376	Q13507
AHFLLSVFFVIFSFP	WFS1	406	O76024
FSVASLITLFHLFLF	KIAA2013	596	Q8IYS2
AFFLDHVRTSFLLNL	MYO1C	806	O00159
SAFLHFGLVTFVLFL	SLC8A3	11	P57103
NFFLLLLVLAVLFFH	TMEM35A	91	Q53FP2