Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol transfer activity

PITPNM1 PITPNM2

1.63e-0411352GO:0008526
GeneOntologyMolecularFunctionphosphatidylcholine transporter activity

PITPNM1 PITPNM2

5.56e-0420352GO:0008525
GeneOntologyMolecularFunctionK48-linked deubiquitinase activity

USP7 USP8

6.14e-0421352GO:1990380
GeneOntologyMolecularFunctionphospholipid transfer activity

PITPNM1 PITPNM2

9.45e-0426352GO:0120014
GeneOntologyBiologicalProcesscranial skeletal system development

FOXE1 IRX5 MED12 HOXA1

1.22e-0584354GO:1904888
MousePhenoabnormal neural crest cell migration

SOX10 MED12 HOXA1

5.10e-0534303MP:0002950
MousePhenoabnormal head mesenchyme morphology

SOX10 MED12 PTK2

5.57e-0535303MP:0011260
MousePhenoabnormal neural crest cell physiology

SOX10 MED12 HOXA1

1.04e-0443303MP:0012745
DomainIP_trans

PITPNM1 PITPNM2

3.60e-055362PF02121
DomainLNS2

PITPNM1 PITPNM2

5.39e-056362PF08235
DomainDDHD_dom

PITPNM1 PITPNM2

5.39e-056362IPR004177
DomainLNS2

PITPNM1 PITPNM2

5.39e-056362IPR013209
DomainPI_transfer

PITPNM1 PITPNM2

5.39e-056362IPR001666
DomainLNS2

PITPNM1 PITPNM2

5.39e-056362SM00775
DomainDDHD

PITPNM1 PITPNM2

5.39e-056362SM01127
DomainDDHD

PITPNM1 PITPNM2

5.39e-056362PF02862
DomainDDHD

PITPNM1 PITPNM2

5.39e-056362PS51043
DomainLNS2/PITP

PITPNM1 PITPNM2

5.39e-056362IPR031315
Domain-

PITPNM1 NT5C2 PITPNM2

2.53e-04643633.40.50.1000
DomainHAD-like_dom

PITPNM1 NT5C2 PITPNM2

4.70e-0479363IPR023214
Domain-

PITPNM1 PITPNM2

8.91e-04233623.30.530.20
DomainSTART-like_dom

PITPNM1 PITPNM2

8.91e-0423362IPR023393
DomainS100_CABP

FLG2 RPTN

1.23e-0327362PS00303
DomainS_100

FLG2 RPTN

1.23e-0327362PF01023
DomainS100_Ca-bd_sub

FLG2 RPTN

1.32e-0328362IPR013787
DomainS100/CaBP-9k_CS

FLG2 RPTN

1.32e-0328362IPR001751
DomainS_100

FLG2 RPTN

1.32e-0328362SM01394
DomainUBA-like

NT5C2 UBAP2L

6.76e-0364362IPR009060
DomainUSP_CS

USP7 USP8

7.17e-0366362IPR018200
DomainUSP_1

USP7 USP8

8.03e-0370362PS00972
DomainUCH

USP7 USP8

8.26e-0371362PF00443
DomainUSP_2

USP7 USP8

8.26e-0371362PS00973
DomainUSP_3

USP7 USP8

8.48e-0372362PS50235
DomainUSP_dom

USP7 USP8

8.48e-0372362IPR028889
DomainPeptidase_C19_UCH

USP7 USP8

8.48e-0372362IPR001394
PathwayREACTOME_SYNTHESIS_OF_PI

PITPNM1 PITPNM2

4.97e-055322MM14587
PathwayREACTOME_SYNTHESIS_OF_PI

PITPNM1 PITPNM2

4.97e-055322M26962
Pubmed

Human transcription factor protein interaction networks.

NT5C2 USP7 ZNF462 SOX10 HNRNPUL1 WDR1 FLG2 UBAP2L SEC24B SORL1

1.27e-061429361035140242
Pubmed

Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3.

PITPNM1 PITPNM2

3.12e-06336215627748
Pubmed

Cloning and characterization of a novel variant (mM-rdgBbeta1) of mouse M-rdgBs, mammalian homologs of Drosophila retinal degeneration B gene proteins, and its mRNA localization in mouse brain in comparison with other M-rdgBs.

PITPNM1 PITPNM2

3.12e-06336212562526
Pubmed

WD repeat-containing protein 1 maintains β-Catenin activity to promote pancreatic cancer aggressiveness.

USP7 WDR1

3.12e-06336232601462
Pubmed

Pitpnm1 is expressed in hair cells during development but is not required for hearing.

PITPNM1 PITPNM2

3.12e-06336223820044
Pubmed

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.

USP7 USP8

3.12e-06336227444016
Pubmed

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein.

PITPNM1 PITPNM2

6.24e-06436210022914
Pubmed

Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine.

PITPNM1 PITPNM2

6.24e-06436211104777
Pubmed

Neuronal ER-plasma membrane junctions organized by Kv2-VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis.

PITPNM1 PITPNM2

6.24e-06436231594866
Pubmed

Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes.

USP7 USP8

1.56e-05636227501351
Pubmed

Linkage analysis of the genetic determinants of T-cell IL-4 secretion, and identification of Flj20274 as a putative candidate gene.

SOX10 PTK2

1.56e-05636215815685
Pubmed

Deubiquitinase USP8 increases ID1 stability and promotes esophageal squamous cell carcinoma tumorigenesis.

USP7 USP8

1.56e-05636235636624
Pubmed

Deubiquitylation and stabilization of PTEN by USP13.

USP7 USP8

2.18e-05736224270891
Pubmed

Plasticity of neural crest-placode interaction in the developing visceral nervous system.

SOX10 HOXA1

2.91e-05836221674689
Pubmed

Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish.

SOX10 HOXA1

2.91e-05836236941270
Pubmed

Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo.

SOX10 HOXA1

2.91e-05836215367676
Pubmed

USP11 Is a Negative Regulator to γH2AX Ubiquitylation by RNF8/RNF168.

USP7 USP8

2.91e-05836226507658
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

USP7 ZNF207 PDIA6 HNRNPUL1 UBAP2L SEC24B

3.44e-0560736639147351
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

NT5C2 USP7 ZNF207 TNKS WDR1 UBAP2L SORL1

3.68e-0591636732203420
Pubmed

Hoxa1 and Hoxb1 are required for pharyngeal arch artery development.

SOX10 HOXA1

3.73e-05936227956219
Pubmed

Identification and validation of selective deubiquitinase inhibitors.

USP7 USP8

3.73e-05936234129829
Pubmed

The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways.

USP7 USP8

3.73e-05936228973533
Pubmed

The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types.

USP7 USP8

3.73e-05936222195557
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

USP7 USP8 PDIA6 HNRNPUL1 WDR1 UBAP2L SEC24B

4.16e-0593436733916271
Pubmed

Lack of in vivo functional compensation between Pax family groups II and III in rodents.

FOXE1 SOX10

4.66e-051036221512107
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NT5C2 ZNF462 TNKS WDR1 UBAP2L ADAM22 PTK2

5.05e-0596336728671696
Pubmed

Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.

USP8 SEC24B

5.70e-051136229604273
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

USP7 ZNF462 HNRNPUL1 MED12

7.83e-0522036435785414
Pubmed

Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.

TMTC4 UBAP2L SEC24B

7.92e-058036316094384
Pubmed

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.

USP7 HNRNPUL1

9.41e-051436222653443
Pubmed

Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere.

SOX10 HOXA1

9.41e-051436220171203
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

USP7 ZNF462 ZNF207 PDIA6 HNRNPUL1 FLG2 MED12

1.05e-04108236738697112
Pubmed

Deubiquitinating enzymes: a new class of biological regulators.

USP7 USP8

1.08e-04153629827704
Pubmed

Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest.

SOX10 HOXA1

1.08e-041536211532923
Pubmed

Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.

NT5C2 USP8

1.08e-041536224482476
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

DNAJB4 HNRNPUL1 UBAP2L MED12 ADAM22

1.09e-0446236531138677
Pubmed

USP25 regulates Wnt signaling by controlling the stability of tankyrases.

TNKS KLHL13

1.24e-041636228619731
Pubmed

A strategy for modulation of enzymes in the ubiquitin system.

USP7 USP8

1.40e-041736223287719
Pubmed

Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia.

SOX10 MED12

1.58e-041836223575864
Pubmed

Ablation of Ezh2 in neural crest cells leads to aberrant enteric nervous system development in mice.

SOX10 HOXA1

1.96e-042036230169530
Pubmed

Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system.

SOX10 ADAM22

1.96e-042036221068328
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

PITPNM1 PITPNM2 ADAM22 PTK2

2.00e-0428136428706196
Pubmed

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities.

USP7 UBAP2L

2.38e-042236234799561
Pubmed

OTUB1 modulates c-IAP1 stability to regulate signalling pathways.

USP7 WDR1

2.83e-042436223524849
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

USP7 SOX10 USP8 TNKS HNRNPUL1 ADAM22 PTK2

3.01e-04128536735914814
Pubmed

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

USP7 HNRNPUL1 WDR1

3.40e-0413136334551306
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

DNAJB4 ZNF207 USP8 HNRNPUL1 SETD5 SEC24B SORL1

3.56e-04132136727173435
Pubmed

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.

CR1 SORL1

3.87e-042836220534741
Pubmed

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.

USP7 USP8

3.87e-042836222118674
Pubmed

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

NT5C2 MAP2K5

3.87e-042836224861553
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

USP7 PDIA6 HNRNPUL1 WDR1 MED12 PTK2 SEC24B

4.12e-04135336729467282
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

USP7 USP8 WDR1 UBAP2L

4.32e-0434436430333137
Pubmed

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.

USP7 PDIA6 FLG2 UBAP2L MED12

4.35e-0462436533729478
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

PITPNM1 UBAP2L ADAM22 PTK2

4.46e-0434736417114649
Pubmed

Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.

USP7 DNAJB4 UBAP2L

4.58e-0414536328846114
Pubmed

Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.

HNRNPUL1 SEC24B

5.07e-043236219542561
Pubmed

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

DNAJB4 WDR1 UBAP2L

5.26e-0415236316009940
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

USP7 ZNF207 USP8 TNKS RPTN KLHL13

5.32e-04100536619615732
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

USP7 DNAJB4 USP8 PDIA6 HNRNPUL1 FLG2 UBAP2L

5.38e-04141536728515276
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

ZNF207 HNRNPUL1 UBAP2L

5.46e-0415436316055720
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

USP7 GBA3 ZNF207 PNPLA8 PDIA6 HNRNPUL1 UBAP2L

5.61e-04142536730948266
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

USP7 ZNF207 HNRNPUL1 WDR1 FLG2

5.62e-0466036532780723
Pubmed

Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.

USP7 UBAP2L SORL1

5.67e-0415636329961565
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PITPNM1 USP7 PITPNM2 PDIA6 WDR1 UBAP2L ADAM22

5.76e-04143136737142655
Pubmed

Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity.

DNAJB4 HNRNPUL1 WDR1 UBAP2L

5.91e-0437436423824909
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

NT5C2 USP7 DNAJB4 USP8 PDIA6 HNRNPUL1 WDR1

6.35e-04145536722863883
Pubmed

A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate.

USP7 USP8

6.42e-043636222626734
Pubmed

Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics.

MED12 PTK2

6.42e-043636215717329
Pubmed

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.

CR1 SORL1

6.78e-043736224162737
Pubmed

The protein interaction landscape of the human CMGC kinase group.

USP7 UBAP2L MED12 PTK2 SORL1

7.09e-0469536523602568
Pubmed

An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.

USP7 PDIA6 WDR1 FLG2

7.38e-0439736421319273
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

USP8 SETD5 UBAP2L KLHL13

8.10e-0440736412693553
Pubmed

TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.

USP7 HNRNPUL1 UBAP2L

8.45e-0417936336261009
Pubmed

CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.

PDIA6 PTK2 KLHL13

8.86e-0418236331067453
Pubmed

Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.

FOXE1 UBAP2L

9.59e-044436220200978
Cytoband1q21.3

FLG2 UBAP2L RPTN

1.08e-041173631q21.3
CytobandEnsembl 112 genes in cytogenetic band chr1q21

ITGA10 FLG2 UBAP2L RPTN

2.79e-04404364chr1q21
GeneFamilyPhosphatidylinositol transfer proteins

PITPNM1 PITPNM2

3.71e-0562921151
GeneFamilyEF-hand domain containing|S100 fused type protein family

FLG2 RPTN

5.19e-0572921350
GeneFamilyUbiquitin specific peptidases

USP7 USP8

3.63e-0356292366
Diseasesmoking status measurement

NT5C2 DNAJB4 ZNF207 WDR1 TMTC4 MAP2K5 UBAP2L PTK2 SORL1

7.84e-061160369EFO_0006527
DiseaseParoxysmal atrial fibrillation

ZNF462 WDR1 PTK2 SORL1

3.88e-05156364C0235480
DiseasePersistent atrial fibrillation

ZNF462 WDR1 PTK2 SORL1

3.88e-05156364C2585653
Diseasefamilial atrial fibrillation

ZNF462 WDR1 PTK2 SORL1

3.88e-05156364C3468561
DiseaseAtrial Fibrillation

ZNF462 WDR1 PTK2 SORL1

4.28e-05160364C0004238
DiseaseMental deterioration

CR1 SORL1

5.18e-059362C0234985
DiseaseMild cognitive disorder

CR1 SORL1

5.18e-059362C1270972
DiseaseImpaired cognition

CR1 SORL1

1.30e-0414362C0338656
DiseaseAlzheimer disease, educational attainment

PITPNM2 USP8 CR1 SORL1

2.29e-04247364EFO_0011015, MONDO_0004975
Diseaselate-onset Alzheimers disease

ZNF462 CR1 SEC24B SORL1

4.31e-04292364EFO_1001870
Diseasesmoking behavior, body mass index

NT5C2 DNAJB4 MAP2K5

4.56e-04123363EFO_0004318, EFO_0004340
DiseaseHirschsprung Disease

SOX10 MED12

6.58e-0431362C0019569
Diseasesmoking behavior

NT5C2 MAP2K5 PTK2 SORL1

7.71e-04341364EFO_0004318
Diseaseprostate cancer (is_marker_for)

MAP2K5 SETD5 PTK2

9.11e-04156363DOID:10283 (is_marker_for)
Diseaseatrial fibrillation

ZNF462 WDR1 PTK2 SORL1

1.05e-03371364EFO_0000275
DiseaseCongenital Heart Defects

IRX5 HOXA1

1.33e-0344362C0018798
Diseasemicroglial activation measurement

GBA3 MAP2K5

2.37e-0359362EFO_0010940

Protein segments in the cluster

PeptideGeneStartEntry
TYTGPLQHGIVYSGG

NT5C2

316

P49902
GGEHCYYQGHIRGNP

ADAM22

131

Q9P0K1
GYTNYGSFGHLHGHP

IRX5

411

P78411
HGSYGPAEYDYGHTG

FLG2

2346

Q5D862
SGTHTHSGPAGYFQY

ASAH2

191

Q9NR71
GVFTGPGGHSYQGHW

JPH4

51

Q96JJ6
TLGHGNGGTVYKAYH

MAP2K5

171

Q13163
SGYVHQQAPTYGHGL

MED12

1996

Q93074
VSPSHGGQYRCYGAH

LILRA6

286

Q6PI73
HQGYAGGAVGSPQYI

HOXA1

146

P49639
GGAVGSPQYIHHSYG

HOXA1

151

P49639
GPGGSGQYTHKVYHV

PITPNM2

51

Q9BZ72
GQGGTFRYTFHGDPH

DNAJB4

81

Q9UDY4
EPHYGHAGTVYGGVM

KLHL13

476

Q9P2N7
NGHYIGGHVSLYLPG

CR1

1856

P17927
PGIPHFGTGGYQAAH

GBA3

181

Q9H227
GHQGALYLYHGTQSG

ITGA10

576

O75578
GYGLHHQNYIAPSGH

SEC24B

56

O95487
YHASGHSVAYKPGGF

CLDN18

211

P56856
HHSLGGQYGVQGFPT

PDIA6

86

Q15084
HAEPGGYSGPDGHYA

HNRNPUL1

86

Q9BUJ2
RNYGHFPGINSHYLG

PNPLA8

581

Q9NP80
GPHYYTWGDHGGIIT

SORL1

536

Q92673
AGAYHARHAAAYPGG

FOXE1

351

O00358
HYQVSGYPGSHGITA

PTK2

741

Q05397
SQHYPHRGSGGVHQY

SETD5

1411

Q9C0A6
NGGKSYIYSGSHDGH

WDR1

331

O75083
GPGGSGQYTHKVYHV

PITPNM1

51

O00562
YYLSGGFHPVGFHVV

TMTC4

96

Q5T4D3
QPSGYGSHGYNTGVS

UBAP2L

956

Q14157
GGLVPLHNACSYGHY

TNKS

401

O95271
GGLVPLHNACSYGHY

TNKS

716

O95271
HPGHVSSYSAAGYGL

SOX10

306

P56693
GQYGGHHQGMPGYLP

ZNF207

426

O43670
NATSLGTGGYYGHSP

ZNF462

76

Q96JM2
YGHSPGYYGQHIAAN

ZNF462

86

Q96JM2
SYHYGQPDGQGQSSH

RPTN

496

Q6XPR3
HGGHYVVYLNPKGDG

USP7

461

Q93009
VSNHYGGLDGGHYTA

USP8

1056

P40818