Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	linoleoyl-CoA desaturase activity	FADS1 FADS2	1.96e-05	2	89	2	GO:0016213
GeneOntologyMolecularFunction	efflux transmembrane transporter activity	ABCC4 SLC17A3 XPR1	4.60e-05	16	89	3	GO:0015562
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	TRPM6 KCNG2 CACNA1S ANO9 ABCC4 ATP7A SLC17A3 TRPM7 KCNG4 CACNA1H ZDHHC13 XPR1	1.33e-04	758	89	12	GO:0015318
GeneOntologyMolecularFunction	acyl-CoA desaturase activity	FADS1 FADS2	1.95e-04	5	89	2	GO:0016215
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	TRPM6 SFXN4 KCNG2 CACNA1S ANO9 ATP7A SLC17A3 TRPM7 KCNG4 CACNA1H ZDHHC13 CHRNB3	2.03e-04	793	89	12	GO:0015075
GeneOntologyMolecularFunction	monoatomic ion channel activity	TRPM6 KCNG2 CACNA1S ANO9 SLC17A3 TRPM7 KCNG4 CACNA1H CHRNB3	2.07e-04	459	89	9	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	TRPM6 KCNG2 CACNA1S ATP7A SLC17A3 TRPM7 KCNG4 CACNA1H ZDHHC13	2.28e-04	465	89	9	GO:0046873
GeneOntologyMolecularFunction	mannosyltransferase activity	DPY19L2 DPY19L2P2 ALG12	2.59e-04	28	89	3	GO:0000030
GeneOntologyMolecularFunction	vasopressin receptor activity	OXTR NPSR1	4.07e-04	7	89	2	GO:0005000
GeneOntologyMolecularFunction	2-acylglycerol O-acyltransferase activity	MOGAT2 LPGAT1	5.41e-04	8	89	2	GO:0003846
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR52K1 TAS2R16 OXTR OR5D18 ADGRE3 NPSR1 GPR141 CMKLR1 OR5M3 TAS2R38 OR4D5 CRHR1	5.42e-04	884	89	12	GO:0004930
GeneOntologyMolecularFunction	channel activity	TRPM6 KCNG2 CACNA1S ANO9 SLC17A3 TRPM7 KCNG4 CACNA1H CHRNB3	5.52e-04	525	89	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	TRPM6 KCNG2 CACNA1S ANO9 SLC17A3 TRPM7 KCNG4 CACNA1H CHRNB3	5.59e-04	526	89	9	GO:0022803
GeneOntologyMolecularFunction	urate transmembrane transporter activity	ABCC4 SLC17A3	6.93e-04	9	89	2	GO:0015143
GeneOntologyMolecularFunction	salt transmembrane transporter activity	ABCC4 SLC17A3	6.93e-04	9	89	2	GO:1901702
GeneOntologyMolecularFunction	transmembrane transporter activity	TRPM6 SFXN4 KCNG2 CACNA1S ANO9 ABCC4 ATP7A SLC17A3 TRPM7 KCNG4 CACNA1H ZDHHC13 CHRNB3 XPR1	6.98e-04	1180	89	14	GO:0022857
GeneOntologyMolecularFunction	gated channel activity	KCNG2 CACNA1S ANO9 SLC17A3 KCNG4 CACNA1H CHRNB3	7.33e-04	334	89	7	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	TRPM6 KCNG2 CACNA1S ATP7A SLC17A3 TRPM7 KCNG4 CACNA1H ZDHHC13 CHRNB3	7.39e-04	664	89	10	GO:0008324
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPM6 KCNG2 CACNA1S TRPM7 KCNG4 CACNA1H CHRNB3	8.57e-04	343	89	7	GO:0005261
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	KCNG2 CACNA1S SLC17A3 KCNG4 CACNA1H	1.33e-03	182	89	5	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	KCNG2 CACNA1S SLC17A3 KCNG4 CACNA1H	1.40e-03	184	89	5	GO:0022832
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	FADS1 FADS2	1.48e-03	13	89	2	GO:0016717
GeneOntologyMolecularFunction	transporter activity	TRPM6 SFXN4 KCNG2 CACNA1S ANO9 ABCC4 ATP7A SLC17A3 TRPM7 KCNG4 CACNA1H ZDHHC13 CHRNB3 XPR1	1.63e-03	1289	89	14	GO:0005215
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1S CACNA1H	1.73e-03	14	89	2	GO:0008331
GeneOntologyMolecularFunction	peptide hormone binding	OXTR CMKLR1 CRHR1	1.90e-03	55	89	3	GO:0017046
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	TRPM6 KCNG2 CACNA1S ATP7A SLC17A3 TRPM7 KCNG4 CACNA1H ZDHHC13	1.91e-03	627	89	9	GO:0022890
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	IL12RB1 OR52K1 TAS2R16 OXTR OR5D18 ADGRE3 NPSR1 GPR141 CMKLR1 OR5M3 TAS2R38 OR4D5 CRHR1 CHRNB3	2.56e-03	1353	89	14	GO:0004888
GeneOntologyMolecularFunction	calcium channel activity	TRPM6 CACNA1S TRPM7 CACNA1H	2.66e-03	129	89	4	GO:0005262
GeneOntologyMolecularFunction	endopeptidase activator activity	PSENEN NLRC4	3.20e-03	19	89	2	GO:0061133
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPM6 CACNA1S TRPM7 CACNA1H	4.67e-03	151	89	4	GO:0015085
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	KCNG2 CACNA1S KCNG4 CACNA1H	4.78e-03	152	89	4	GO:0022843
GeneOntologyMolecularFunction	phosphate transmembrane transporter activity	SLC17A3 XPR1	5.09e-03	24	89	2	GO:0005315
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	TRPM6 SFXN4 KCNG2 CACNA1S ANO9 NLGN3 ABCC4 PLLP ATP7A SLC17A3 TRPM7 KCNG4 NPSR1 CACNA1H ZDHHC13 CRHR1 CHRNB3 PML	1.27e-06	1115	90	18	GO:0034220
GeneOntologyBiologicalProcess	monoatomic ion transport	TRPM6 SFXN4 KCNG2 CACNA1S ANO9 NLGN3 ABCC4 PLLP ATP7A SLC17A3 TRPM7 KCNG4 NPSR1 CACNA1H NKAIN3 ZDHHC13 CRHR1 CHRNB3 PML	5.97e-06	1374	90	19	GO:0006811
GeneOntologyCellularComponent	endoplasmic reticulum membrane	CYB5RL FADS1 MCTP1 STX18 SLC17A3 ACER3 HACD3 MOGAT2 RPN2 PSENEN OR5D18 LPGAT1 FADS2 TMED2 SEL1L2 RNF145 ALG12 PML	9.83e-06	1293	91	18	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	CYB5RL FADS1 MCTP1 STX18 SLC17A3 ACER3 HACD3 MOGAT2 RPN2 PSENEN OR5D18 LPGAT1 FADS2 TMED2 SEL1L2 RNF145 ALG12 PML	1.05e-05	1299	91	18	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	CYB5RL FADS1 MCTP1 STX18 SLC17A3 ACER3 HACD3 MOGAT2 RPN2 PSENEN OR5D18 LPGAT1 FADS2 TMED2 SEL1L2 RNF145 ALG12 PML	1.40e-05	1327	91	18	GO:0042175
GeneOntologyCellularComponent	interleukin-12 receptor complex	TYK2 IL12RB1	5.61e-05	3	91	2	GO:0042022
GeneOntologyCellularComponent	interleukin-23 receptor complex	TYK2 IL12RB1	1.12e-04	4	91	2	GO:0072536
GeneOntologyCellularComponent	brush border	TRPM6 TMPRSS15 ATP7A SLC17A3 RAPGEF4	5.35e-04	152	91	5	GO:0005903
Domain	Ion_trans_dom	TRPM6 KCNG2 CACNA1S TRPM7 KCNG4 CACNA1H	1.63e-05	114	88	6	IPR005821
Domain	Ion_trans	TRPM6 KCNG2 CACNA1S TRPM7 KCNG4 CACNA1H	1.63e-05	114	88	6	PF00520
Domain	K_chnl_volt-dep_Kv6	KCNG2 KCNG4	6.56e-05	3	88	2	IPR003969
Domain	Fatty_acid_desaturase	FADS1 FADS2	6.56e-05	3	88	2	IPR012171
Domain	EMP70	TM9SF2 TM9SF4	1.31e-04	4	88	2	PF02990
Domain	TRPM_tetra	TRPM6 TRPM7	1.31e-04	4	88	2	IPR032415
Domain	TRPM_tetra	TRPM6 TRPM7	1.31e-04	4	88	2	PF16519
Domain	EMP70	TM9SF2 TM9SF4	1.31e-04	4	88	2	IPR004240
Domain	Channel_four-helix_dom	KCNG2 CACNA1S KCNG4 CACNA1H	1.50e-04	57	88	4	IPR027359
Domain	-	KCNG2 CACNA1S KCNG4 CACNA1H	1.50e-04	57	88	4	1.20.120.350
Domain	Vasoprsn_rcpt	OXTR NPSR1	2.17e-04	5	88	2	IPR001817
Domain	MARVEL	PLLP SYNPR SYNGR4	2.72e-04	27	88	3	PF01284
Domain	Marvel	PLLP SYNPR SYNGR4	3.04e-04	28	88	3	IPR008253
Domain	MARVEL	PLLP SYNPR SYNGR4	3.04e-04	28	88	3	PS51225
Domain	Alpha_kinase	TRPM6 TRPM7	3.25e-04	6	88	2	PF02816
Domain	ALPHA_KINASE	TRPM6 TRPM7	3.25e-04	6	88	2	PS51158
Domain	Alpha_kinase	TRPM6 TRPM7	3.25e-04	6	88	2	SM00811
Domain	MHCK_EF2_kinase	TRPM6 TRPM7	3.25e-04	6	88	2	IPR004166
Domain	FA_desaturase_dom	FADS1 FADS2	6.03e-04	8	88	2	IPR005804
Domain	FA_desaturase	FADS1 FADS2	6.03e-04	8	88	2	PF00487
Domain	VDCCAlpha1	CACNA1S CACNA1H	9.64e-04	10	88	2	IPR002077
Domain	CYTOCHROME_B5_2	FADS1 FADS2	1.66e-03	13	88	2	PS50255
Domain	CYTOCHROME_B5_1	FADS1 FADS2	1.66e-03	13	88	2	PS00191
Domain	SEA	TMPRSS15 IMPG1	1.93e-03	14	88	2	SM00200
Domain	Cyt-b5	FADS1 FADS2	1.93e-03	14	88	2	PF00173
Domain	Cyt_B5-like_heme/steroid-bd	FADS1 FADS2	1.93e-03	14	88	2	IPR001199
Domain	Cyt-b5	FADS1 FADS2	1.93e-03	14	88	2	SM01117
Domain	-	FADS1 FADS2	1.93e-03	14	88	2	3.10.120.10
Domain	-	TMPRSS15 IMPG1	2.21e-03	15	88	2	3.30.70.960
Domain	Fd_Rdtase_FAD-bd	CYB5RL NOX1	3.56e-03	19	88	2	IPR017927
Domain	FAD_FR	CYB5RL NOX1	3.56e-03	19	88	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	CYB5RL NOX1	3.56e-03	19	88	2	IPR017938
Domain	PH	RALGPS1 CYTH1 TBC1D2 TBC1D2B MCF2	4.56e-03	229	88	5	PF00169
Domain	SEA	TMPRSS15 IMPG1	4.77e-03	22	88	2	PF01390
Domain	NACHT	NLRC5 NLRC4	5.21e-03	23	88	2	PS50837
Domain	NACHT_NTPase	NLRC5 NLRC4	5.21e-03	23	88	2	IPR007111
Domain	SEA	TMPRSS15 IMPG1	5.21e-03	23	88	2	PS50024
Domain	SEA_dom	TMPRSS15 IMPG1	5.21e-03	23	88	2	IPR000082
Domain	TAS2R	TAS2R16 TAS2R38	6.63e-03	26	88	2	PF05296
Domain	RASGEF	RALGPS1 RAPGEF4	6.63e-03	26	88	2	PS00720
Domain	T2R	TAS2R16 TAS2R38	6.63e-03	26	88	2	IPR007960
Domain	K_chnl_volt-dep_Kv	KCNG2 KCNG4	7.14e-03	27	88	2	IPR003968
Domain	RASGEF_CAT	RALGPS1 RAPGEF4	8.20e-03	29	88	2	PS50009
Domain	RasGEF	RALGPS1 RAPGEF4	8.76e-03	30	88	2	PF00617
Domain	-	RALGPS1 RAPGEF4	8.76e-03	30	88	2	1.10.840.10
Domain	Ras_GEF_dom	RALGPS1 RAPGEF4	8.76e-03	30	88	2	IPR023578
Domain	RASGEF_cat_dom	RALGPS1 RAPGEF4	8.76e-03	30	88	2	IPR001895
Domain	RasGEF	RALGPS1 RAPGEF4	8.76e-03	30	88	2	SM00147
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	FANCD2 DPY19L2 TM9SF2 TM9SF4 SMCHD1 FADS2 TSN TMED2 TSPAN14 BTAF1 RNF145 ZDHHC13 NCAPG2 ADCY9	6.68e-07	1061	91	14	33845483
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	FANCD2 SFXN4 FADS1 STX18 TM9SF2 HACD3 RPN2 LEMD2 LPGAT1 BTAF1 TSPYL1 NCAPG2	6.44e-06	942	91	12	31073040
Pubmed	Impact of FADS genotype on polyunsaturated fatty acid content in human milk extracellular vesicles: A genetic association study.	FADS1 FADS2	6.77e-06	2	91	2	38566550
Pubmed	The channel kinases TRPM6 and TRPM7 are functionally nonredundant.	TRPM6 TRPM7	6.77e-06	2	91	2	16150690
Pubmed	Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population.	FADS1 FADS2	6.77e-06	2	91	2	29491470
Pubmed	TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP.	TRPM6 TRPM7	6.77e-06	2	91	2	28821869
Pubmed	FADS1 FADS2 gene cluster, PUFA intake and blood lipids in children: results from the GINIplus and LISAplus studies.	FADS1 FADS2	6.77e-06	2	91	2	22629455
Pubmed	Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.	TRPM6 TRPM7	6.77e-06	2	91	2	16636202
Pubmed	A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle.	FADS1 FADS2	6.77e-06	2	91	2	20364269
Pubmed	Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.	FADS1 FADS2	6.77e-06	2	91	2	20948998
Pubmed	Recent developments in intestinal magnesium absorption.	TRPM6 TRPM7	6.77e-06	2	91	2	18301276
Pubmed	Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans.	FADS1 FADS2	6.77e-06	2	91	2	24962583
Pubmed	The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC.	TRPM6 TRPM7	6.77e-06	2	91	2	18675813
Pubmed	Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans.	TAS2R16 TAS2R38	6.77e-06	2	91	2	18524836
Pubmed	Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.	FADS1 FADS2	6.77e-06	2	91	2	32186652
Pubmed	Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition.	FADS1 FADS2	6.77e-06	2	91	2	23221573
Pubmed	Long-chain polyunsaturated fatty acid status in obesity: a systematic review and meta-analysis.	FADS1 FADS2	6.77e-06	2	91	2	25828602
Pubmed	FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children.	FADS1 FADS2	6.77e-06	2	91	2	21793953
Pubmed	Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement.	FADS1 FADS2	6.77e-06	2	91	2	23160180
Pubmed	FADS2 polymorphisms are associated with plasma arachidonic acid and estimated desaturase-5 activity in a cross-sectional study.	FADS1 FADS2	6.77e-06	2	91	2	33011673
Pubmed	Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study.	FADS1 FADS2	6.77e-06	2	91	2	20484448
Pubmed	Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients.	FADS1 FADS2	6.77e-06	2	91	2	19875987
Pubmed	TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions.	TRPM6 TRPM7	6.77e-06	2	91	2	24858416
Pubmed	Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children.	FADS1 FADS2	6.77e-06	2	91	2	21106917
Pubmed	Adiposity Associated Plasma Linoleic Acid is Related to Demographic, Metabolic Health and Haplotypes of FADS1/2 Genes in Irish Adults.	FADS1 FADS2	6.77e-06	2	91	2	29388724
Pubmed	FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer.	FADS1 FADS2	6.77e-06	2	91	2	38926633
Pubmed	Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases.	TRPM6 TRPM7	6.77e-06	2	91	2	28220887
Pubmed	Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models.	NLGN3 OXTR	6.77e-06	2	91	2	33335150
Pubmed	Docosahexaenoic acid (DHA) supplementation in pregnancy differentially modulates arachidonic acid and DHA status across FADS genotypes in pregnancy.	FADS1 FADS2	6.77e-06	2	91	2	25500337
Pubmed	FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.	FADS1 FADS2	6.77e-06	2	91	2	28555039
Pubmed	Influence of FADS polymorphisms on tracking of serum glycerophospholipid fatty acid concentrations and percentage composition in children.	FADS1 FADS2	6.77e-06	2	91	2	21818279
Pubmed	Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.	TAS2R16 TAS2R38	6.77e-06	2	91	2	17250611
Pubmed	Associations of umbilical cord fatty acid profiles and desaturase enzyme indices with birth weight for gestational age in Japanese infants.	FADS1 FADS2	6.77e-06	2	91	2	33387849
Pubmed	FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases.	FADS1 FADS2	6.77e-06	2	91	2	19776639
Pubmed	Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women.	TRPM6 TRPM7	6.77e-06	2	91	2	19149903
Pubmed	The role of FADS1/2 polymorphisms on cardiometabolic markers and fatty acid profiles in young adults consuming fish oil supplements.	FADS1 FADS2	6.77e-06	2	91	2	24936800
Pubmed	FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome.	FADS1 FADS2	6.77e-06	2	91	2	26879377
Pubmed	Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease.	FADS1 FADS2	6.77e-06	2	91	2	25038994
Pubmed	Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7.	TRPM6 TRPM7	6.77e-06	2	91	2	18365021
Pubmed	Genetically determined variation in polyunsaturated fatty acid metabolism may result in different dietary requirements.	FADS1 FADS2	6.77e-06	2	91	2	18626191
Pubmed	Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.	TRPM6 TRPM7	6.77e-06	2	91	2	14976260
Pubmed	Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio.	FADS1 FADS2	6.77e-06	2	91	2	27613800
Pubmed	Transient receptor potential melastatin 6 and 7 channels, magnesium transport, and vascular biology: implications in hypertension.	TRPM6 TRPM7	6.77e-06	2	91	2	18192217
Pubmed	High Frequency of Ancestral Haplotype A of Fatty Acid Desaturase Genes in the Yakut Population.	FADS1 FADS2	6.77e-06	2	91	2	38860387
Pubmed	Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function.	FADS1 FADS2	6.77e-06	2	91	2	38316767
Pubmed	GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice.	FADS1 FADS2	6.77e-06	2	91	2	36806390
Pubmed	FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression.	FADS1 FADS2	6.77e-06	2	91	2	30157936
Pubmed	A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids.	FADS1 FADS2	6.77e-06	2	91	2	22619218
Pubmed	Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids.	FADS1 FADS2	6.77e-06	2	91	2	16670158
Pubmed	Limited Evidence for Selection at the FADS Locus in Native American Populations.	FADS1 FADS2	6.77e-06	2	91	2	32145021
Pubmed	Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus.	DPY19L2 DPY19L2P2	6.77e-06	2	91	2	22764053
Pubmed	Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.	FADS1 FADS2	6.77e-06	2	91	2	27004414
Pubmed	FADS Polymorphism, Omega-3 Fatty Acids and Diabetes Risk: A Systematic Review.	FADS1 FADS2	6.77e-06	2	91	2	29899246
Pubmed	Dietary pattern regulates fatty acid desaturase 1 gene expression in Indian pregnant women to spare overall long chain polyunsaturated fatty acids levels.	FADS1 FADS2	6.77e-06	2	91	2	30511301
Pubmed	Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism.	FADS1 FADS2	6.77e-06	2	91	2	19809313
Pubmed	Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia.	TRPM6 TRPM7	6.77e-06	2	91	2	21602712
Pubmed	Maternal polymorphisms in the FADS1 and FADS2 genes modify the association between PUFA ingestion and plasma concentrations of omega-3 polyunsaturated fatty acids.	FADS1 FADS2	6.77e-06	2	91	2	31568926
Pubmed	Magnesium homeostasis in colon carcinoma LoVo cells sensitive or resistant to doxorubicin.	TRPM6 TRPM7	6.77e-06	2	91	2	26563869
Pubmed	Do FADS genotypes enhance our knowledge about fatty acid related phenotypes?	FADS1 FADS2	6.77e-06	2	91	2	19948371
Pubmed	The role of fatty acid desaturase (FADS) genes in oleic acid metabolism: FADS1 Δ7 desaturates 11-20:1 to 7,11-20:2.	FADS1 FADS2	6.77e-06	2	91	2	29413358
Pubmed	Insertion-deletions in a FADS2 intron 1 conserved regulatory locus control expression of fatty acid desaturases 1 and 2 and modulate response to simvastatin.	FADS1 FADS2	6.77e-06	2	91	2	22748975
Pubmed	The Different Roles of The Channel-Kinases TRPM6 and TRPM7.	TRPM6 TRPM7	6.77e-06	2	91	2	26179995
Pubmed	Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.	FADS1 FADS2	6.77e-06	2	91	2	26474818
Pubmed	Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis.	TRPM6 TRPM7	6.77e-06	2	91	2	16075242
Pubmed	Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.	FADS1 FADS2	6.77e-06	2	91	2	20691134
Pubmed	Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study.	FADS1 FADS2	6.77e-06	2	91	2	20980488
Pubmed	Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome.	FADS1 FADS2	6.77e-06	2	91	2	21733300
Pubmed	Increasing dietary EPA and DHA influence estimated fatty acid desaturase activity in systemic organs which is reflected in the red blood cell in mice.	FADS1 FADS2	6.77e-06	2	91	2	28697636
Pubmed	Evidence for the expression of TRPM6 and TRPM7 in cardiomyocytes from all four chamber walls of the human heart.	TRPM6 TRPM7	6.77e-06	2	91	2	34326388
Pubmed	FADS1 and FADS2 polymorphism are associated with changes in fatty acid concentrations after calorie-restricted Central European and Mediterranean diets.	FADS1 FADS2	6.77e-06	2	91	2	31567872
Pubmed	Carrying minor allele of FADS1 and haplotype of FADS1 and FADS2 increased the risk of metabolic syndrome and moderate but not low fat diets lowered the risk in two Korean cohorts.	FADS1 FADS2	6.77e-06	2	91	2	29779171
Pubmed	Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes.	FADS1 FADS2	6.77e-06	2	91	2	18479586
Pubmed	Differences in erythrocyte phospholipid membrane long-chain polyunsaturated fatty acids and the prevalence of fatty acid desaturase genotype among African Americans and European Americans.	FADS1 FADS2	6.77e-06	2	91	2	33310680
Pubmed	Differential mRNA expression and glucocorticoid-mediated regulation of TRPM6 and TRPM7 in the heart and kidney throughout murine pregnancy and development.	TRPM6 TRPM7	6.77e-06	2	91	2	25692682
Pubmed	Mendelian randomization shows sex-specific associations between long-chain PUFA-related genotypes and cognitive performance in Danish schoolchildren.	FADS1 FADS2	6.77e-06	2	91	2	28515069
Pubmed	Erythrocyte polyunsaturated fatty acid composition is associated with depression and FADS genotype in Caucasians.	FADS1 FADS2	6.77e-06	2	91	2	28552045
Pubmed	Association of fatty acid desaturase genes with attention-deficit/hyperactivity disorder.	FADS1 FADS2	6.77e-06	2	91	2	16893529
Pubmed	Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essential fatty acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation.	FADS1 FADS2	6.77e-06	2	91	2	18936223
Pubmed	TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon.	TRPM6 TRPM7	6.77e-06	2	91	2	29912157
Pubmed	Magnesium and its transporters in cancer: a novel paradigm in tumour development.	TRPM6 TRPM7	6.77e-06	2	91	2	22671428
Pubmed	The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.	TRPM6 TRPM7	6.77e-06	2	91	2	24385424
Pubmed	Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells.	FADS1 FADS2	6.77e-06	2	91	2	23211517
Pubmed	Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.	FADS1 FADS2	6.77e-06	2	91	2	20427696
Pubmed	Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster.	FADS1 FADS2	6.77e-06	2	91	2	28957329
Pubmed	Polyunsaturated fatty acid regulation of adipocyte FADS1 and FADS2 expression and function.	FADS1 FADS2	6.77e-06	2	91	2	25755223
Pubmed	Early nutrition in combination with polymorphisms in fatty acid desaturase gene cluster modulate fatty acid composition of cheek cells' glycerophospholipids in school-age children.	FADS1 FADS2	6.77e-06	2	91	2	31638497
Pubmed	Interaction of fatty acid genotype and diet on changes in colonic fatty acids in a Mediterranean diet intervention study.	FADS1 FADS2	6.77e-06	2	91	2	24022589
Pubmed	TRPM7 and CaV3.2 channels mediate Ca2+ influx required for egg activation at fertilization.	TRPM7 CACNA1H	6.77e-06	2	91	2	30322909
Pubmed	Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.	FADS1 FADS2	6.77e-06	2	91	2	36864135
Pubmed	Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior.	FADS1 FADS2	6.77e-06	2	91	2	26513616
Pubmed	FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk.	FADS1 FADS2	6.77e-06	2	91	2	20335541
Pubmed	Association of two polymorphisms in the FADS1/FADS2 gene cluster and the risk of coronary artery disease and ischemic stroke.	FADS1 FADS2	6.77e-06	2	91	2	26261632
Pubmed	FADS1 and FADS2 Gene Polymorphisms Modulate the Relationship of Omega-3 and Omega-6 Fatty Acid Plasma Concentrations in Gestational Weight Gain: A NISAMI Cohort Study.	FADS1 FADS2	6.77e-06	2	91	2	35268031
Pubmed	Gene variation of the transient receptor potential cation channel, subfamily M, members 6 (TRPM6) and 7 (TRPM7), and type 2 diabetes mellitus: a case-control study.	TRPM6 TRPM7	6.77e-06	2	91	2	20875900
Pubmed	Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development.	DPY19L2 DPY19L2P2	6.77e-06	2	91	2	25354700
Pubmed	Subcellular localization of phospholipase Cζ in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation.	DPY19L2 DPY19L2P2	6.77e-06	2	91	2	25354701
Pubmed	Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism.	FADS1 FADS2	6.77e-06	2	91	2	20045144
Pubmed	Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults.	FADS1 FADS2	6.77e-06	2	91	2	21414826
Pubmed	FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease.	FADS1 FADS2	6.77e-06	2	91	2	18842780
Pubmed	Associations between Fatty Acid Intake and Status, Desaturase Activities, and FADS Gene Polymorphism in Centrally Obese Postmenopausal Polish Women.	FADS1 FADS2	6.77e-06	2	91	2	30103441
Interaction	CMKLR1 interactions	FANCD2 ABCC4 FADS1 LEMD2 BTAF1 CMKLR1 XPR1	2.13e-07	101	84	7	int:CMKLR1
Interaction	TTYH1 interactions	ABCC4 FADS1 STX18 TRPM7 HACD3 LEMD2 CACNA1H ALG12 ADCY9 XPR1	4.81e-07	300	84	10	int:TTYH1
Interaction	CTXN1 interactions	ABCC4 TMED2 ZDHHC13 ADCY9	1.05e-05	33	84	4	int:CTXN1
Interaction	GPR182 interactions	FANCD2 SFXN4 FADS1 RPN2 TM9SF4 LPGAT1 BTAF1 MED23 NCAPG2 XPR1	1.94e-05	455	84	10	int:GPR182
Cytoband	3p25	OXTR MKRN2	5.18e-04	17	91	2	3p25
Cytoband	11q23.2	NXPE4 TTC12	5.82e-04	18	91	2	11q23.2
Cytoband	11q13.5	ACER3 MOGAT2	7.96e-04	21	91	2	11q13.5
Cytoband	16q13	PLLP NLRC5	2.34e-03	36	91	2	16q13
Cytoband	Ensembl 112 genes in cytogenetic band chr16q13	PLLP NLRC5	2.89e-03	40	91	2	chr16q13
Cytoband	Ensembl 112 genes in cytogenetic band chr3p25	FANCD2 OXTR MKRN2	3.69e-03	155	91	3	chr3p25
Cytoband	19p13.1	IL12RB1 ADGRE3	4.13e-03	48	91	2	19p13.1
Cytoband	1q32	CACNA1S LPGAT1	4.30e-03	49	91	2	1q32
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	FADS1 OR5D18 FADS2 OR5M3	5.01e-03	345	91	4	chr11q12
GeneFamily	Transmembrane 9 superfamily members	TM9SF2 TM9SF4	6.69e-05	4	61	2	1239
GeneFamily	Fatty acid desaturases	FADS1 FADS2	3.09e-04	8	61	2	553
GeneFamily	NLR family	NLRC5 NLRC4	3.20e-03	25	61	2	666
GeneFamily	Calcium voltage-gated channel subunits	CACNA1S CACNA1H	3.45e-03	26	61	2	253
GeneFamily	Transient receptor potential cation channels	TRPM6 TRPM7	4.00e-03	28	61	2	249
GeneFamily	Taste 2 receptors	TAS2R16 TAS2R38	7.66e-03	39	61	2	1162
GeneFamily	Potassium voltage-gated channels	KCNG2 KCNG4	8.04e-03	40	61	2	274
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TRPM6 OXTR KCNG4 EXOC6B GPR141 NCAPG2	8.25e-07	156	91	6	14e2f693a75f1075f40cc7b16ee430262a5de016
Disease	phosphatidylcholine acyl-alkyl C36:5 measurement	FADS1 FADS2 TMEM229B	2.47e-07	5	87	3	EFO_0801293
Disease	1-(1-enyl-stearoyl)-2-arachidonoyl-GPC (P-18:0/20:4) measurement	FADS1 FADS2 TMEM229B	4.92e-07	6	87	3	EFO_0800394
Disease	1-(1-enyl-palmitoyl)-GPC (P-16:0) measurement	FADS1 FADS2 TMEM229B	4.92e-07	6	87	3	EFO_0800323
Disease	level of Phosphatidylcholine (O-18:2_20:4) in blood serum	FADS1 FADS2 TMEM229B	8.59e-07	7	87	3	OBA_2045135
Disease	1-(1-enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4) measurement	FADS1 FADS2 TMEM229B	1.37e-06	8	87	3	EFO_0800423
Disease	1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1) measurement	FADS1 FADS2 TMEM229B	1.37e-06	8	87	3	EFO_0800420
Disease	level of Phosphatidylcholine (O-16:1_20:4) in blood serum	FADS1 FADS2 TMEM229B	4.02e-06	11	87	3	OBA_2045123
Disease	1-(1-enyl-palmitoyl)-2-palmitoyl-GPC (P-16:0/16:0) measurement	FADS1 FADS2 TMEM229B	5.34e-06	12	87	3	EFO_0800466
Disease	phosphatidylcholine 40:7 measurement	FADS1 MOGAT2 FADS2	6.93e-06	13	87	3	EFO_0021477
Disease	phosphatidylcholine ether measurement	FADS1 FADS2 TMEM229B	6.93e-06	13	87	3	EFO_0010227
Disease	level of Phosphatidylcholine (18:1_20:2) in blood serum	FADS1 MOGAT2 FADS2	8.80e-06	14	87	3	OBA_2045102
Disease	1-(1-enyl-palmitoyl)-2-myristoyl-GPC (P-16:0/14:0) measurement	FADS2 TMEM229B	2.57e-05	3	87	2	EFO_0800465
Disease	Palmitoyl-arachidonoyl-glycerol (16:0/20:4) [2] measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0022103
Disease	Sphingomyelin (d18:2/14:0, d18:1/14:1) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0022114
Disease	2-arachidonoylglycerol (20:4) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800182
Disease	2-linoleoyl-GPC (18:2) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800239
Disease	1-dihomo-linoleoyl-GPC (20:2) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800236
Disease	docosapentaenoate (n6 DPA; 22:5n6) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800249
Disease	1-linoleoyl-2-docosahexaenoyl-GPC (18:2/22:6) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0022080
Disease	1-margaroyl-2-arachidonoyl-GPC (17:0/20:4) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0022081
Disease	1-arachidoyl-2-arachidonoyl-GPC (20:0/20:4) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0022079
Disease	phosphatidylcholine (O-18:1/20:4, O-16:0/22:5n3) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800553
Disease	arachidonate 20:4n6-to-dihomo-linolenate 20:3n3 or n6 ratio	FADS1 FADS2	5.14e-05	4	87	2	EFO_0021517
Disease	fatty acid measurement, linolenic acid measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0005110, EFO_0006811
Disease	phosphatidylcholine acyl-alkyl C38:5 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0801299
Disease	phosphatidylcholine acyl-alkyl C36:4 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0801292
Disease	phosphatidylcholine acyl-alkyl C36:2 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0801290
Disease	phosphatidylcholine diacyl C38:5 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0801267
Disease	phosphatidylcholine diacyl C38:4 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0801266
Disease	phosphatidylcholine diacyl C36:4 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0801260
Disease	phosphatidylcholine diacyl C40:6 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0801274
Disease	phosphatidylcholine diacyl C36:3 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0801259
Disease	phosphatidylcholine diacyl C34:4 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0801255
Disease	level of Phosphatidylcholine (O-16:0_22:5) in blood serum	FADS1 FADS2	5.14e-05	4	87	2	OBA_2045117
Disease	sphingomyeline C16:1 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0801318
Disease	1-linoleoyl-2-linolenoyl-GPC (18:2/18:3) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800483
Disease	eicosapentaenoylcholine measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800482
Disease	comprehensive strength index, muscle measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0004515, EFO_0004979
Disease	1-stearoyl-2-adrenoyl-GPC (18:0/22:4) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800459
Disease	1-palmitoyl-2-meadoyl-GPC (16:0/20:3n9) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800458
Disease	phosphatidylcholine (18:0/20:5, 16:0/22:5n6) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800468
Disease	1-stearoyl-2-meadoyl-GPC (18:0/20:3n9) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800463
Disease	1-pentadecanoyl-2-arachidonoyl-GPC (15:0/20:4) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800446
Disease	1-palmitoyl-2-alpha-linolenoyl-GPC (16:0/18:3n3) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800442
Disease	1-palmitoyl-2-eicosapentaenoyl-GPC (16:0/20:5) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800408
Disease	phosphatidylcholine 33:2 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0021470
Disease	phosphatidylcholine 33:1 measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0021469
Disease	1,2-dilinoleoyl-GPC (18:2/18:2) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800388
Disease	1-eicosapentaenoyl-GPC (20:5) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800355
Disease	1-(1-enyl-stearoyl)-GPC (P-18:0) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800325
Disease	1-(1-enyl-oleoyl)-GPC (P-18:1) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800324
Disease	1-lignoceroyl-GPC (24:0) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800322
Disease	1-adrenoyl-GPC (22:4) measurement	FADS1 FADS2	5.14e-05	4	87	2	EFO_0800321
Disease	2-arachidonoyl-GPC (20:4) measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0800237
Disease	1-arachidonoyl-GPC (20:4n6) measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0800234
Disease	1-linoleoyl-GPC (18:2) measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0800223
Disease	fatty acid measurement, docosapentaenoic acid measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0005110, EFO_0006809
Disease	sphingomyeline C18:1 measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0801320
Disease	1-palmitoleoyl-2-linolenoyl-GPC (16:1/18:3) measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0800484
Disease	phosphatidylcholine (16:0/22:5n3, 18:1/20:4) measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0800467
Disease	1-(1-enyl-stearoyl)-2-arachidonoyl-GPE (P-18:0/20:4) measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0800415
Disease	1-palmitoyl-2-dihomo-linolenoyl-GPC (16:0/20:3n3 or 6) measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0800407
Disease	1-(1-enyl-palmitoyl)-2-arachidonoyl-GPE (P-16:0/20:4) measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0800417
Disease	1-linolenoyl-GPE (18:3) measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0800365
Disease	1-(1-enyl-stearoyl)-GPE (P-18:0) measurement	FADS1 FADS2	8.54e-05	5	87	2	EFO_0800335
Disease	Sphingomyelin (d18:1/20:1, d18:2/20:0) measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0022110
Disease	Sphingomyelin (d18:1/18:1, d18:2/18:0) measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0022108
Disease	1-stearoyl-GPC (18:0) measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0800217
Disease	1-arachidonylglycerol (20:4) measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0800224
Disease	procollagen C-endopeptidase enhancer 1 measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0801920
Disease	arachidonic acid measurement, fatty acid measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0005110, EFO_0006808
Disease	adrenate 22:4n6 measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0021062
Disease	1-arachidonoylglycerophosphocholine measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0021076
Disease	dihomo-linolenate 20:3n3 or n6 measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0021046
Disease	docosapentaenoate n3 DPA; 22:5n3 measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0021048
Disease	1-linoleoylglycerophosphoethanolamine measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0021084
Disease	level of Phosphatidylcholine (18:2_0:0) in blood serum	FADS1 FADS2	1.28e-04	6	87	2	OBA_2045105
Disease	1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6) measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0800390
Disease	level of Phosphatidylcholine (O-18:2_18:2) in blood serum	FADS1 FADS2	1.28e-04	6	87	2	OBA_2045134
Disease	level of Phosphatidylcholine (O-16:0_18:2) in blood serum	FADS1 FADS2	1.28e-04	6	87	2	OBA_2045114
Disease	arachidonoylcholine measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0800478
Disease	1-oleoyl-2-docosahexaenoyl-GPE (18:1/22:6) measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0800471
Disease	1-stearoyl-2-dihomo-linolenoyl-GPC (18:0/20:3n3 or 6) measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0800434
Disease	level of Phosphatidylinositol (18:1_18:2) in blood serum	FADS1 FADS2	1.28e-04	6	87	2	OBA_2045160
Disease	1-palmitoyl-2-dihomo-linolenoyl-GPE (16:0/20:3) measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0800444
Disease	1-palmityl-2-arachidonoyl-GPC (O-16:0/20:4) measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0800426
Disease	1-stearoyl-2-linoleoyl-GPC (18:0/18:2) measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0800404
Disease	lysophosphatidylcholine 18:3 measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0021454
Disease	1-docosapentaenoyl-GPC (22:5n3) measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0800298
Disease	level of Phosphatidylcholine (18:0_20:2) in blood serum	FADS1 FADS2	1.28e-04	6	87	2	OBA_2045092
Disease	1-(1-enyl-stearoyl)-2-linoleoyl-GPE (P-18:0/18:2)* measurement	FADS1 FADS2	1.28e-04	6	87	2	EFO_0020014
Disease	Alcoholic Intoxication, Chronic	TAS2R16 TTC12 NPSR1 TAS2R38 CRHR1 CHRNB3	1.45e-04	268	87	6	C0001973
Disease	X-24870 measurement	FADS1 FADS2	1.79e-04	7	87	2	EFO_0022143
Disease	1,2-dipalmitoyl-GPC (16:0/16:0) measurement	FADS1 FADS2	1.79e-04	7	87	2	EFO_0800189
Disease	1-arachidonoyl-GPI (20:4) measurement	FADS1 FADS2	1.79e-04	7	87	2	EFO_0800256
Disease	1-linoleoyl-GPI (18:2) measurement	FADS1 FADS2	1.79e-04	7	87	2	EFO_0800266
Disease	1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) measurement	FADS1 FADS2	1.79e-04	7	87	2	EFO_0800609
Disease	eicosapentaenoate (EPA; 20:5n3) measurement	FADS1 FADS2	1.79e-04	7	87	2	EFO_0800616
Disease	level of Sterol ester (27:1/22:6) in blood serum	FADS1 FADS2	1.79e-04	7	87	2	OBA_2045201
Disease	arachidonate 20:4n6 measurement	FADS1 FADS2	1.79e-04	7	87	2	EFO_0021063

Protein segments in the cluster

Peptide	Gene	Start	Entry
LNTSVVFGFLNFILW	SYNPR	176	Q8TBG9
AVFLWIIIAINFSNS	FAM74A1	96	Q5RGS3
FVAQVLDRIFLWLFL	CHRNB3	421	Q05901
IFLLGFLFWNIDNIF	ACER3	181	Q9NUN7
FLFWNIDNIFCESLR	ACER3	186	Q9NUN7
NSWFIVFRETFLVHQ	ADGB	1001	Q8N7X0
FTFTILDNRIWFRNF	BRIX1	206	Q8TDN6
WFLLAIRLAFVILFE	ANO9	696	A1A5B4
NLRNFLLFQLWESSF	MIR9-1HG	11	Q13536
RFIWLSAFAIIVFRV	ALG12	171	Q9BV10
EIRQWRRSFLVSLFF	ATP7A	646	Q04656
RFFNSVRLWDFIENR	MKRN2	371	Q9H000
VVAFTRRFNQVSFWV	RALGPS1	91	Q5JS13
FVAVFLWLVTIVLFN	PLLP	71	Q9Y342
FWAQLKNLFFIGVIL	GPR141	221	Q7Z602
NQWLLFFLATFNEIS	OR5D18	196	Q8NGL1
VVWLGLNVFLFVDAF	NOX1	16	Q9Y5S8
LFLNFIRFLESHWFV	FADS2	321	O95864
ALERQIFDFLGFQWA	NKAIN3	21	Q8N8D7
GWRNVFFLLFAVNLL	SLC17A3	381	O00476
ELKIGSFRFFWIQNV	KIAA0100	41	Q14667
NLWIFLIQSFAFLSG	LPGAT1	341	Q92604
RSLAAFVLFLFVVWN	MCTP1	806	Q6DN14
LFFNWKQEFRTLEVT	NLRC4	651	Q9NPP4
VQFLGFSWIFVNLTV	HACD3	156	Q9P035
FTGLVNILTDINWRF	NPSR1	96	Q6W5P4
RALLTAVTNVLIFFW	LEMD2	371	Q8NC56
RRAIFVFWIFLQVQG	IMPG1	6	Q17R60
NGSIIVVFDLFFAQW	TMPRSS15	116	P98073
AWFSLEFCLRFVQAQ	KCNG4	271	Q8TDN1
SILLIQGFFRDIWVF	PCNX1	1021	Q96RV3
VAWFSFEFLLRSLQA	KCNG2	226	Q9UJ96
VGNWNFDIFLFDRLT	PDE7A	151	Q13946
WQHLSSQLIFFVLFQ	MED23	331	Q9ULK4
LQEQARFWNVRTFFV	CYB5RL	231	Q6IPT4
FTDLNLVQALRQFLW	CYTH1	136	Q15438
FWQATAIFLAVGIFI	LHFPL2	96	Q6ZUX7
AFIDLRQLLDLFIQW	EXOC6B	726	Q9Y2D4
QRQVLFLFLFWGVSL	PCDHB10	11	Q9UN67
FQVLPQLLWDITFRF	OXTR	91	P30559
TSRREWQVLFFIIFL	OR5M3	16	Q8NGP4
WQFAQFILFTQIASL	DPY19L2	341	Q6NUT2
LVNIFWFFREAFLVP	PSENEN	31	Q9NZ42
FSTLQWLFRLDISFE	NLRC5	1056	Q86WI3
WERRLQTLAVLQFVF	MOGAT2	11	Q3SYC2
WIVFIFLILLNTAAQ	ABCC4	711	O15439
QIQALRWVSENIAFF	NLGN3	261	Q9NZ94
IQNNVLELWSLFDFL	BTAF1	1436	O14981
VNATWFTNFILLFIL	CACNA1S	796	Q13698
FFLLLLLVWFLNREF	ADCY9	986	O60503
NLISAFILRNATWFV	CRHR1	186	P34998
GLFFIVRFLESNWFV	FADS1	321	O60427
RFSIEVQVSDWLIFF	IL12RB1	536	P42701
WIIFRNAIENFALTV	MCF2	91	P10911
VQITQFFRFDGWLIN	ENGASE	221	Q8NFI3
FFRFDGWLINIENSL	ENGASE	226	Q8NFI3
NFDSLLWAIVTVFQI	CACNA1H	956	O95180
WQFAQFILFTQIASL	DPY19L2P2	151	Q6ZN68
IFLTLNWFREIVNAF	FANCD2	786	Q9BXW9
GLSQVWELRFVFFTV	OR4D5	16	Q8NGN0
QRQVLFLFLFWGVSL	PCDHB9	11	Q9Y5E1
IFWFRDQEINFFACL	OR52K1	86	Q8NGK4
EFFNILTFWLNSLLT	TAS2R16	86	Q9NYV7
LTNAFVFLVNFWDVV	TAS2R38	31	P59533
FLRRFNEIQFWVVTE	RAPGEF4	816	Q8WZA2
FTWREFSDFIRVQLI	SMCHD1	1236	A6NHR9
FWITERQSFIRRFLQ	SFXN4	31	Q6P4A7
LWEFTTGFILRQFNA	TMEM229B	86	Q8NBD8
FILASWIIFTVFQNS	NXPE4	16	Q6UWF7
LLRDILFFNFTTRWN	SEL1L2	641	Q5TEA6
NFFRALEDINRLWEF	PML	686	P29590
QWSLLLAVLVFFLFA	ST6GALNAC1	16	Q9NSC7
FSANLVLFILVFWIL	ADGRE3	516	Q9BY15
VWFLNLAVADFLFNV	CMKLR1	76	Q99788
RRFLSCLFNWNINFI	NCAPG2	226	Q86XI2
FLRIWVSFIFALVQH	TECTA	6	O75443
VFRRFVWNFFRLENE	XPR1	601	Q9UBH6
FTVDERSILWLNQFL	UHRF1BP1L	531	A0JNW5
IIFWFSRLLDFFAVN	TRPM6	946	Q9BX84
FSWSTFLLLNQLFQI	ZDHHC13	531	Q8IUH4
IELFFIFSAIWENQF	TM9SF4	516	Q92544
LFALWIRIGANVSNF	RPN2	556	P04844
FIRRNQDLICSFFTW	TSPYL1	366	Q9H0U9
IKNNAGFRVWILFFL	STX18	306	Q9P2W9
IFFFFQRWSLTLSLR	GAFA1	21	Q96PS6
AFQLLDFILAVLWAV	SYNGR4	101	O95473
NSRVVLWSFFEALVL	TMED2	166	Q15363
FIQLFFILNSIWSHQ	TM9SF2	536	Q99805
LALEERFQVWFQANL	TTC12	411	Q9H892
LAVAVLAFLFQDWVR	TSPAN14	106	Q8NG11
LYRWDVSSFFQQIQR	RNF145	26	Q96MT1
LITFNWFLVVFVDSV	TBC1D2B	826	Q9UPU7
FWYVRLLDFLAVNQQ	TRPM7	971	Q96QT4
NWFLVVFADSLISNI	TBC1D2	791	Q9BYX2
FNLFALFDAQAQVWL	TYK2	71	P29597
WRFVLQRLVFLAAFV	TSN	91	Q15631