Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of skin epidermis

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT75 LORICRIN KRT81 KRT83 KRT86 KRT79

8.36e-21436612GO:0030280
GeneOntologyMolecularFunctionstructural molecule activity

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 LORICRIN KRT81 KRT28 KRT83 KRT86 NUP214 NUP58 FLG2 KRT79 KRT25 SNTB1

4.59e-138916621GO:0005198
GeneOntologyBiologicalProcessintermediate filament organization

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRT79 KRT25

1.25e-25756616GO:0045109
GeneOntologyBiologicalProcessintermediate filament cytoskeleton organization

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRT79 KRT25

1.57e-23996616GO:0045104
GeneOntologyBiologicalProcessintermediate filament-based process

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRT79 KRT25

1.86e-231006616GO:0045103
GeneOntologyBiologicalProcesskeratinization

KRT2 KRT3 KRT4 KRT5 KRT76 LCE4A KRT75 LORICRIN KRT81 KRT83 KRT86 HRNR KRT79

8.96e-19876613GO:0031424
GeneOntologyBiologicalProcessskin development

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 LCE4A KRT75 KRT27 LORICRIN KRT81 KRT28 KRT83 KRT86 HRNR FLG2 KRT79 KRT25

8.83e-173736618GO:0043588
GeneOntologyBiologicalProcesskeratinocyte differentiation

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 LCE4A KRT75 LORICRIN KRT81 KRT83 KRT86 HRNR KRT79

9.23e-161896614GO:0030216
GeneOntologyBiologicalProcessepidermis development

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 LCE4A KRT75 KRT27 LORICRIN KRT81 KRT28 KRT83 KRT86 HRNR FLG2 KRT79 KRT25

3.56e-154616618GO:0008544
GeneOntologyBiologicalProcessepidermal cell differentiation

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 LCE4A KRT75 LORICRIN KRT81 KRT83 KRT86 HRNR KRT79

2.61e-132846614GO:0009913
GeneOntologyBiologicalProcessepithelial cell differentiation

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 LCE4A KRT75 KRT27 LORICRIN KRT81 KRT28 KRT83 KRT86 HRNR KRT79 KRT25

1.65e-118706619GO:0030855
GeneOntologyBiologicalProcessepithelium development

HOXA11 KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 LCE4A KRT75 KRT27 LORICRIN KRT81 KRT28 KRT83 KRT86 HRNR FLG2 KRT79 KRT25

2.77e-0914696621GO:0060429
GeneOntologyBiologicalProcesssupramolecular fiber organization

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRT79 KRT25

3.92e-089576616GO:0097435
GeneOntologyBiologicalProcessepidermis morphogenesis

KRT27 KRT28 FLG2 KRT25

1.41e-0546664GO:0048730
GeneOntologyBiologicalProcesspeptide cross-linking

KRT2 KRT10 LORICRIN

8.66e-0527663GO:0018149
GeneOntologyBiologicalProcessskin epidermis development

KRT27 KRT28 HRNR FLG2 KRT25

1.91e-04166665GO:0098773
GeneOntologyBiologicalProcesshair follicle morphogenesis

KRT27 KRT28 KRT25

2.84e-0440663GO:0031069
GeneOntologyCellularComponentintermediate filament

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRTAP13-1 KRT79 KRTAP15-1 KRT25

9.64e-212276618GO:0005882
GeneOntologyCellularComponentintermediate filament cytoskeleton

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRTAP13-1 KRT79 KRTAP15-1 KRT25

1.39e-192636618GO:0045111
GeneOntologyCellularComponentkeratin filament

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT75 KRT81 KRT83 KRT86 KRT79 KRT25

1.98e-16976612GO:0045095
GeneOntologyCellularComponentcornified envelope

KRT2 KRT5 KRT10 KRT75 DSG3 LORICRIN HRNR FLG2

4.57e-1169668GO:0001533
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRTAP13-1 KRT79 KRTAP15-1 KRT25

2.09e-108996618GO:0099513
GeneOntologyCellularComponentsupramolecular fiber

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRTAP13-1 KRT79 KRTAP15-1 KRT25

1.52e-0811796618GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRTAP13-1 KRT79 KRTAP15-1 KRT25

1.68e-0811876618GO:0099081
GeneOntologyCellularComponentkeratohyalin granule

HRNR FLG2

9.76e-055662GO:0036457
HumanPhenoPerifollicular hyperkeratosis

KRT81 KRT83 KRT86

4.16e-074253HP:0007468
HumanPhenoAbnormal perifollicular morphology

KRT81 KRT83 KRT86

2.07e-066253HP:0031285
HumanPhenoBrittle hair

KRT81 KRT83 KRT86 GNPTAB KRT25

5.01e-0654255HP:0002299
HumanPhenoSlow-growing hair

KRT81 KRT83 KRT86 KRT25

9.87e-0629254HP:0002217
HumanPhenoAbnormality of hair growth rate

KRT81 KRT83 KRT86 KRT25

9.87e-0629254HP:0011363
HumanPhenoFine hair

KRT81 KRT83 KRT86 GNPTAB HECTD4 KRT25

1.12e-05110256HP:0002213
HumanPhenoAbnormality of hair growth

KRT81 KRT83 KRT86 KRT25

1.14e-0530254HP:0040170
HumanPhenoAbnormality of keratinization

KRT2 KRT5 KRT10 LORICRIN KRT81 KRT83 KRT86 FLG2

1.31e-05244258HP:0001035
HumanPhenoParakeratosis

KRT5 KRT10 LORICRIN FLG2

1.68e-0533254HP:0001036
HumanPhenoThickened skin

KRT2 KRT5 KRT10 LORICRIN KRT81 KRT83 PI4KA KRT86 GNPTAB FLG2

1.73e-054312510HP:0001072
HumanPhenoSkin plaque

KRT5 KRT10 LORICRIN KRT83

6.98e-0547254HP:0200035
HumanPhenoNail dystrophy

KRT5 LORICRIN KRT81 KRT83 PI4KA KRT86

8.19e-05156256HP:0008404
HumanPhenoHyperkeratosis

KRT2 KRT5 KRT10 LORICRIN KRT81 KRT83 KRT86

9.07e-05233257HP:0000962
HumanPhenoOrthokeratosis

KRT10 LORICRIN FLG2

1.13e-0420253HP:0040162
HumanPhenoCongenital bullous ichthyosiform erythroderma

KRT2 KRT10

1.38e-044252HP:0007475
HumanPhenoPalmoplantar keratoderma

KRT2 KRT5 KRT10 LORICRIN KRT83

1.91e-04114255HP:0000982
HumanPhenoNail dysplasia

KRT5 LORICRIN KRT81 KRT83 PI4KA KRT86 BHLHA9

1.99e-04264257HP:0002164
HumanPhenoPatchy alopecia

KRT81 KRT83 KRT86

2.52e-0426253HP:0002232
HumanPhenoEpidermal thickening

KRT2 KRT5 KRT10 LORICRIN KRT81 KRT83 KRT86 FLG2

3.05e-04379258HP:0011368
HumanPhenoPalmoplantar hyperkeratosis

KRT2 KRT5 KRT10 LORICRIN KRT83

3.41e-04129255HP:0000972
HumanPhenoOnychogryposis

KRT5 LORICRIN KRT83

3.51e-0429253HP:0001805
HumanPhenoPalmar hyperkeratosis

KRT2 KRT5 KRT10 LORICRIN KRT83

3.66e-04131255HP:0010765
HumanPhenoPlantar hyperkeratosis

KRT2 KRT5 KRT10 LORICRIN KRT83

3.79e-04132255HP:0007556
HumanPhenoFollicular hyperkeratosis

KRT81 KRT83 KRT86

3.89e-0430253HP:0007502
HumanPhenoErythema

KRT2 KRT5 KRT10 LORICRIN KRT83

3.93e-04133255HP:0010783
HumanPhenoCongenital ichthyosiform erythroderma

KRT2 KRT10 LORICRIN

5.17e-0433253HP:0007431
HumanPhenoKeratosis pilaris

KRT81 KRT83 KRT86

7.27e-0437253HP:0032152
MousePhenorough coat

KRT76 KRT75 KRT27 KRT25

1.58e-0624514MP:0010179
MousePhenoabnormal pilosebaceous unit morphology

KRT10 KRT76 KRT75 DSG3 KRT27 HERC3 KRT25

8.82e-06205517MP:0030572
MousePhenoabnormal epidermis suprabasal layer morphology

KRT2 KRT10 DSG3

2.02e-0515513MP:0001233
MousePhenowaved hair

KRT10 KRT27 KRT25

5.81e-0521513MP:0000410
MousePhenoenlarged sebaceous gland

KRT10 KRT76 KRT25

7.70e-0523513MP:0000652
MousePhenoabnormal hair texture

KRT76 KRT75 KRT27 KRT25

7.99e-0563514MP:0002074
MousePhenoabnormal foot pad morphology

KRT2 KRT10 KRT76

1.12e-0426513MP:0000574
MousePhenoabnormal hair shaft morphology

KRT75 DSG3 KRT27 KRT25

1.58e-0475514MP:0003809
MousePhenoabnormal epidermal layer morphology

KRT2 KRT5 KRT10 KRT76 DSG3 LORICRIN

4.35e-04271516MP:0001216
MousePhenohypergranulosis

KRT2 KRT10

4.62e-049512MP:0009600
MousePhenoabnormal autopod morphology

HOXA11 KRT2 KRT5 KRT26 KRT10 KRT76 BHLHA9

5.01e-04390517MP:0000572
MousePhenoabnormal skin coloration

KRT2 KRT4 KRT26 ZNF609 KRT76

5.12e-04182515MP:0011239
DomainIF

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRT79 KRT25

2.23e-25726516PS00226
DomainFilament

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRT79 KRT25

2.85e-25736516PF00038
DomainIF

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRT79 KRT25

5.81e-25766516IPR001664
DomainFilament

KRT2 KRT3 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRT79 KRT25

1.85e-23716515SM01391
DomainKeratin_II

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 KRT79

6.42e-19266510IPR003054
DomainIntermediate_filament_CS

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT24 KRT75 KRT81 KRT83 KRT86 KRT79

2.51e-18636512IPR018039
DomainKeratin_2_head

KRT2 KRT3 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 KRT79

5.28e-1724659IPR032444
DomainKeratin_2_head

KRT2 KRT3 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 KRT79

5.28e-1724659PF16208
DomainKeratin_I

KRT3 KRT4 KRT26 KRT10 KRT76 KRT24 KRT27 KRT28 KRT25

2.71e-1444659IPR002957
DomainGrpE_coiled_coil

KRT3 KRT4 KRT76

8.65e-0612653IPR013805
DomainPrefoldin

KRT4 KRT10 KRT24 KRT75

1.15e-0472654IPR009053
DomainPMG

KRTAP13-1 KRTAP15-1

9.08e-0413652PF05287
DomainKRTAP_PMG

KRTAP13-1 KRTAP15-1

9.08e-0413652IPR007951
DomainS100_CABP

HRNR FLG2

3.96e-0327652PS00303
DomainS_100

HRNR FLG2

3.96e-0327652PF01023
DomainS100_Ca-bd_sub

HRNR FLG2

4.25e-0328652IPR013787
DomainS100/CaBP-9k_CS

HRNR FLG2

4.25e-0328652IPR001751
DomainS_100

HRNR FLG2

4.25e-0328652SM01394
DomainVG_K_chnl

KCNC4 KCNQ4

5.87e-0333652IPR028325
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 LCE4A KRT75 DSG3 KRT27 LORICRIN KRT81 KRT28 KRT83 KRT86 KRT79 KRT25

1.78e-261295119M27649
PathwayREACTOME_KERATINIZATION

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 LCE4A KRT75 DSG3 KRT27 LORICRIN KRT81 KRT28 KRT83 KRT86 KRTAP13-1 KRT79 KRTAP15-1 KRT25

2.46e-252175121M27640
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT2 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 DSG3 KRT27 KRT81 KRT28 KRT83 KRT86 KRT79 KRT25

6.24e-24875116MM15351
PathwayREACTOME_KERATINIZATION

KRT2 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 DSG3 KRT27 KRT81 KRT28 KRT83 KRT86 KRTAP13-1 KRT79 KRT25

1.75e-211535117MM15343
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

KRT2 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 DSG3 KRT27 KRT81 KRT28 KRT83 KRT86 KRTAP13-1 KRT79 KRT25

8.78e-135025117MM14537
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

HOXA11 KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 LCE4A KRT75 DSG3 KRT27 LORICRIN KRT81 KRT28 KRT83 KRT86 KRTAP13-1 KRT79 KRTAP15-1 KRT25

1.03e-0914325122M509
PathwayREACTOME_DIFFERENTIATION_OF_KERATINOCYTES_IN_INTERFOLLICULAR_EPIDERMIS_IN_MAMMALIAN_SKIN

KRT5 KRT10 KRT24 LORICRIN

1.26e-0540514M48231
Pubmed

New consensus nomenclature for mammalian keratins.

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT81 KRT28 KRT83 KRT86 KRT79 KRT25

1.77e-3063671616831889
Pubmed

Charting the molecular network of the drug target Bcr-Abl.

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT24 KRT75 BMP2K KRT81 KRT83 KRT86 KRT79

4.01e-15266671319380743
Pubmed

Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.

KRT2 KRT4 KRT5 KRT75 KRT81 KRT86

3.20e-131667612399393
Pubmed

Assessment of community efforts to advance network-based prediction of protein-protein interactions.

KRT2 KRT3 KRT4 KRT5 KRT26 KRT76 KRT24 LCE4A KRT75 KRT81 KRT28 KRT83 KRT79 KRTAP15-1 KRT25

9.13e-13630671536949045
Pubmed

RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT75

1.75e-115767731862882
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

KRT5 KRT10 KRT76 KRT75 KRT81 KRT83 KRT86 ZBTB10 NUP214 HRNR

1.85e-10284671029459677
Pubmed

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

KRT2 KRT3 KRT4 KRT5 KRT10 HRNR FLG2

2.87e-108467729563501
Pubmed

Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration.

KRT5 KRT10 KRT75 LORICRIN KRT79

4.53e-102167524198274
Pubmed

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

KRT5 KRT10 KRT75 LORICRIN HRNR FLG2

2.30e-096267626644517
Pubmed

Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor.

KRT5 KRT10 DSG3 LORICRIN FLG2

3.13e-093067534905516
Pubmed

The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.

KRT26 KRT27 KRT28 KRT25

6.15e-091267415617563
Pubmed

Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain.

KRT75 KRT81 KRT83 KRT86

6.15e-091267410692104
Pubmed

K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle.

KRT26 KRT27 KRT25

6.83e-09367316874310
Pubmed

Novel KRT83 and KRT86 mutations associated with monilethrix.

KRT81 KRT83 KRT86

6.83e-09367325557232
Pubmed

Structure and site of expression of a murine type II hair keratin.

KRT81 KRT83 KRT86

6.83e-0936731372089
Pubmed

Transient expression of mouse hair keratins in transfected HeLa cells: interactions between "hard" and "soft" keratins.

KRT81 KRT83 KRT86

6.83e-0936731712823
Pubmed

E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis.

KRT2 KRT5 KRT10 KRT27 HRNR FLG2 KRT79

8.13e-0913567729859926
Pubmed

Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope.

KRT2 KRT5 KRT10 LORICRIN

8.87e-09136748999895
Pubmed

Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.

KRT5 KRT10 DSG3 LORICRIN

1.69e-08156749847250
Pubmed

DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.

KRT2 KRT5 KRT10 CHIA KRT75 KRT83 HRNR FLG2

1.97e-0823867835864588
Pubmed

Comprehensive analysis of keratin gene clusters in humans and rodents.

KRT81 KRT83 KRT86 KRT25

2.25e-081667415085952
Pubmed

TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.

KRT2 KRT4 KRT5 KRT10 HRNR FLG2

2.38e-089167634445801
Pubmed

Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament.

KRT27 KRT28 KRT25

2.73e-08467317920809
Pubmed

Keratins of the human hair follicle.

KRT81 KRT83 KRT86

2.73e-08467315797458
Pubmed

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.

KRT2 KRT10 KRT81 KRT83 KRT86 OAS3

3.29e-089667623580065
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT28 HRNR KRT79 KRT25

3.40e-081153671429845934
Pubmed

Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis.

KRT75 KRT81 KRT28 KRT86

4.77e-081967427234308
Pubmed

EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.

KRT2 KRT5 KRT10 HRNR FLG2

6.70e-085467535474131
Pubmed

ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.

KRT2 KRT5 KRT10 KRT76 KRT75 KRT79

8.74e-0811367634474245
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

KRT2 KRT4 KRT5 KRT10 KRT76 PI4KA KRT86 HRNR FLG2 KRT79

1.26e-07564671021565611
Pubmed

Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis.

KRT2 KRT3 KRT5 KRT10

1.30e-072467427507811
Pubmed

Eyelid fusion and epithelial differentiation at the ocular surface during mouse embryonic development.

KRT4 KRT10 KRT86

1.36e-07667315944823
Pubmed

Programming gene expression in developing epidermis.

KRT5 KRT10 LORICRIN

1.36e-0766737525178
Pubmed

Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1.

KRT5 KRT10 LORICRIN

1.36e-07667314638864
Pubmed

The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins.

KRT5 KRT10 LORICRIN

1.36e-07667319300453
Pubmed

Epidermal development requires ninein for spindle orientation and cortical microtubule organization.

KRT5 KRT10 DSG3 LORICRIN

1.82e-072667430923192
Pubmed

A functional reference map of the RNF8 interactome in cancer.

KRT2 KRT3 KRT5 KRT10 HRNR FLG2 CTRL

2.18e-0721867735831895
Pubmed

Regulation of epidermal differentiation by a Distal-less homeodomain gene.

KRT5 KRT10 LORICRIN

2.38e-0776738991098
Pubmed

The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope.

KRT2 KRT10 LORICRIN

3.80e-0786737543090
Pubmed

Essential roles of Tbx3 in embryonic skin development during epidermal stratification.

KRT5 KRT10 LORICRIN

3.80e-07867328205312
Pubmed

Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development.

KRT5 KRT10 LORICRIN

3.80e-07867321136383
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

KRT2 KRT5 KRT10 IRS4 IREB2 HRNR FLG2

4.80e-0724567735652658
Pubmed

Aurora kinase-A deficiency during skin development impairs cell division and stratification.

KRT5 KRT10 LORICRIN

5.69e-07967322832491
Pubmed

Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.

KRT3 KRT76 KRT79

5.69e-07967315737194
Pubmed

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.

KRT5 KRT10 LORICRIN

5.69e-07967322505032
Pubmed

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.

KRT5 KRT10 LORICRIN

8.12e-071067326376988
Pubmed

Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice.

KRT5 KRT10 LORICRIN

8.12e-071067310571739
Pubmed

Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells.

KRT5 KRT10 LORICRIN

8.12e-071067324075906
Pubmed

FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development.

KRT5 KRT10 LORICRIN

1.12e-061167311062007
Pubmed

Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development.

KRT5 KRT10 LORICRIN

1.12e-061167322366455
Pubmed

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

KRT2 KRT4 KRT5 KRT10 ZNF609 KRT27 HRNR FLG2 KRT25

1.24e-0655867927591049
Pubmed

Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.

KRT2 KRT5 KRT10 IRS4 KRT24 HRNR FLG2

1.44e-0628967737132043
Pubmed

The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells.

KRT5 KRT10 LORICRIN

1.48e-061267325503409
Pubmed

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis.

KRT5 KRT10 LORICRIN

1.48e-061267321127502
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

TOB2 ZNF609 KRT76 IRS4 TRO NUP214 HRNR CAMTA1

1.76e-0643067835044719
Pubmed

Fate and plasticity of the epidermis in response to congenital activation of BRAF.

KRT5 KRT10 LORICRIN

1.93e-061367325202828
Pubmed

NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.

KRT5 KRT10 LORICRIN

1.93e-061367326765568
Pubmed

The mineralocorticoid receptor plays a transient role in mouse skin development.

KRT5 KRT10 LORICRIN

1.93e-061367326268211
Pubmed

Glucocorticoid receptor is required for skin barrier competence.

KRT5 KRT10 LORICRIN

1.93e-061367318039792
Pubmed

Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.

KRT4 KRT5 KRT86 HRNR FLG2

2.08e-0610767532989256
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

KRT2 KRT3 KRT4 KRT5 KRT10 KRT83 ZFHX3 HRNR FLG2

2.40e-0660567928977666
Pubmed

Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.

KRT5 KRT10 LORICRIN

2.45e-061467316914743
Pubmed

Ras signaling is essential for skin development.

KRT5 KRT10 LORICRIN

3.06e-061567323831572
Pubmed

Multiple roles of Notch signaling in the regulation of epidermal development.

KRT5 KRT10 LORICRIN

3.06e-061567318410734
Pubmed

DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation.

KRT10 LORICRIN KRT25

3.06e-061567336630508
Pubmed

The histone acetyltransferase inhibitor Nir regulates epidermis development.

KRT5 KRT10 LORICRIN

3.06e-061567329490983
Pubmed

Out of balance: consequences of a partial keratin 10 knockout.

KRT2 KRT10

3.66e-0626729378767
Pubmed

Breast carcinoma with brain metastases: clinical analysis and immunoprofile on tissue microarrays.

KRT5 KRT75

3.66e-06267221427063
Pubmed

Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation.

KRT2 KRT10

3.66e-06267224751727
Pubmed

Allelic variations of human keratins K4 and K5 provide polymorphic markers within the type II keratin gene cluster on chromosome 12.

KRT4 KRT5

3.66e-0626727684424
Pubmed

A missense mutation in the type II hair keratin hHb3 is associated with monilethrix.

KRT83 KRT86

3.66e-06267215744029
Pubmed

A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1.

KRT81 KRT86

3.66e-0626729665406
Pubmed

Keratins K2 and K10 are essential for the epidermal integrity of plantar skin.

KRT2 KRT10

3.66e-06267226603179
Pubmed

The role of cytokeratin 5/6 as an adjunct diagnostic tool in breast core needle biopsies.

KRT5 KRT75

3.66e-06267218499686
Pubmed

A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix.

KRT81 KRT86

3.66e-0626729402962
Pubmed

Desmocollin 3 is required for pre-implantation development of the mouse embryo.

KRT10 DSG3 LORICRIN

3.76e-061667316418220
Pubmed

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.

KRT2 KRT5 KRT10 KRT24 KRT75 KRT81 KRT86 FLG2

4.48e-0648867831324722
Pubmed

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

KRT2 KRT5 KRT10 KRT83 HRNR FLG2 KRT79

4.73e-0634667725324306
Pubmed

m6A RNA methylation impacts fate choices during skin morphogenesis.

KRT5 KRT10 LORICRIN

5.46e-061867332845239
Pubmed

Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha.

KRT5 KRT10 LORICRIN

5.46e-061867320335364
Pubmed

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.

KRT5 KRT10 LORICRIN

5.46e-061867319303854
Pubmed

Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.

KRT2 KRT5 KRT10 LORICRIN

5.65e-066067431220272
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

KRT2 KRT3 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT28 KRT79 KRT25

5.90e-061070671123533145
Pubmed

PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.

KRT81 KRT83 KRT86

6.48e-061967321285247
Pubmed

Diverse Ras-related GTPase DIRAS2, downregulated by PSMD2 in a proteasome-mediated way, inhibits colorectal cancer proliferation by blocking NF-κB signaling.

KRT2 KRT10 HRNR

6.48e-061967335173535
Pubmed

Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation.

KRT5 KRT10 LORICRIN

6.48e-061967324492243
Pubmed

Epidermal inactivation of the glucocorticoid receptor triggers skin barrier defects and cutaneous inflammation.

KRT5 KRT10 LORICRIN

7.61e-062067322951731
Pubmed

Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130.

KRT5 KRT10 LORICRIN

7.61e-062067312702649
Pubmed

Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.

LORICRIN HRNR FLG2

8.87e-062167319601998
Pubmed

Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia.

KRT10 KRT75 LORICRIN

8.87e-062167322935613
Pubmed

Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model.

KRT5 KRT10 LORICRIN

8.87e-062167328688895
Pubmed

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms.

KRT5 KRT10 LORICRIN

1.03e-052267317276340
Pubmed

The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.

KRT5 KRT10 LORICRIN

1.03e-052267316949565
Pubmed

C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation.

KRT5 KRT10 LORICRIN

1.03e-052267319749746
Pubmed

BMP-FGF signaling axis mediates Wnt-induced epidermal stratification in developing mammalian skin.

KRT5 KRT10 LORICRIN

1.03e-052267325329657
Pubmed

Cytokeratin 5/6 and P63 immunophenotype of thyroid lymphoepithelial complexes.

KRT5 KRT75

1.10e-05367227130144
Pubmed

Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.

HRNR FLG2

1.10e-05367223403047
Pubmed

Basal cytokeratin expression in relation to immunohistochemical and clinical characterization in breast cancer patients with triple negative phenotype.

KRT5 KRT75

1.10e-05367219366057
Pubmed

Sequences and differential expression of three novel human type-II hair keratins.

KRT83 KRT86

1.10e-0536729084137
Pubmed

Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis.

KRT5 KRT10

1.10e-05367222170488
InteractionKRT25 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 KRT79 KRT25

6.33e-20356511int:KRT25
InteractionKRT28 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT81 KRT28 KRT86 NUP58 KRT79

1.68e-18306510int:KRT28
InteractionKRT6A interactions

KRT2 KRT3 KRT5 KRT26 KRT10 KRT76 KRT75 DSG3 KRT27 KRT28 PAN2 KRT79 KRT25

3.49e-151606513int:KRT6A
InteractionKRT33B interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 NUP58 KRT79

8.01e-15936511int:KRT33B
InteractionKRT36 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 KRT79

3.61e-14746510int:KRT36
InteractionKRT35 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT27 KRT81 KRT83 KRT86 KRT79

5.95e-141116511int:KRT35
InteractionKRT37 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 KRT79

8.15e-131006510int:KRT37
InteractionKRT27 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT27 KRT81 KRT83 KRT86 NUP58 KRT79

1.87e-122026512int:KRT27
InteractionKRT19 interactions

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT75 KRT81 KRT83 KRT86 PAN2 KRT79 BIRC6

5.13e-122826513int:KRT19
InteractionKRT76 interactions

KRT5 KRT26 KRT10 KRT76 KRT75 KRT27 KRT28 KRT86 KRT25

6.46e-1284659int:KRT76
InteractionKRT24 interactions

KRT2 KRT3 KRT4 KRT5 KRT24 KRT75 KRT81 KRT79

6.94e-1254658int:KRT24
InteractionKRT75 interactions

KRT2 KRT3 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT79 KRT25

1.33e-111816511int:KRT75
InteractionKRT79 interactions

KRT5 KRT26 KRT24 KRT75 KRT27 KRT28 KRT79 KRT25

1.46e-1159658int:KRT79
InteractionKRT26 interactions

KRT3 KRT4 KRT26 KRT76 KRT75 KRT81 KRT79

1.63e-1135657int:KRT26
InteractionKRT20 interactions

KRT2 KRT3 KRT5 KRT76 KRT24 KRT75 KRT27 KRT79

2.53e-1163658int:KRT20
InteractionKRT5 interactions

KRT2 KRT3 KRT5 KRT10 KRT76 KRT24 KRT75 KRT27 KRT28 KRT79 KRT25

2.66e-111936511int:KRT5
InteractionKRT16 interactions

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT75 KRT81 KRT83 KRT86 KRT79

3.32e-111976511int:KRT16
InteractionKRT71 interactions

KRT5 KRT26 KRT24 KRT75 KRT27 KRT28 KRT25

7.66e-1143657int:KRT71
InteractionKRT8 interactions

KRT2 KRT3 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT28 PAN2 KRT79 BIRC6 KRT25

1.04e-104416514int:KRT8
InteractionRNF208 interactions

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT75 KRTAP15-1

1.07e-1075658int:RNF208
InteractionKRT31 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 LCE4A KRT75 KRT81 KRT83 KRT86 BHLHA9 ZFHX3 KRT79 BIRC6

1.48e-104536514int:KRT31
InteractionKRT38 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 KRT79

1.88e-101726510int:KRT38
InteractionKRT84 interactions

KRT2 KRT3 KRT5 KRT10 KRT76 KRT75 KRT79

2.01e-1049657int:KRT84
InteractionKRT1 interactions

KRT2 KRT5 KRT26 KRT10 KRT24 KRT75 KRT27 LORICRIN KRT28 PAN2 KRT25

2.53e-102386511int:KRT1
InteractionKRT15 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 KRT79

2.64e-101786510int:KRT15
InteractionKRT3 interactions

KRT3 KRT5 KRT26 KRT24 KRT75 KRT27 KRT28 KRT25

3.94e-1088658int:KRT3
InteractionKRT72 interactions

KRT5 KRT26 KRT24 KRT75 KRT27 KRT28 KRT25

7.78e-1059657int:KRT72
InteractionKRT34 interactions

KRT2 KRT3 KRT4 KRT5 KRT75 KRT81 KRT83 KRT86 ZFHX3 KRTAP13-1 KRT79

1.58e-092836511int:KRT34
InteractionEPS15 interactions

KRT2 KRT3 KRT4 KRT5 KRT10 KRT75 BMP2K KRT83 KRT86 KRT79

2.08e-092206510int:EPS15
InteractionKRT13 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT79

3.62e-09116658int:KRT13
InteractionPHTF1 interactions

KRT2 KRT3 KRT5 KRT76 KRT75

4.46e-0920655int:PHTF1
InteractionKRT6C interactions

KRT5 KRT26 KRT24 KRT75 KRT27 KRT28 KRT25

4.78e-0976657int:KRT6C
InteractionKRT32 interactions

KRT2 KRT3 KRT5 KRT76 KRT75 KRT86

5.70e-0944656int:KRT32
InteractionKRT6B interactions

KRT5 KRT26 KRT10 KRT24 KRT75 KRT27 KRT28 KRT25

1.01e-08132658int:KRT6B
InteractionKRT14 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT86 KRT79

1.08e-08192659int:KRT14
InteractionKRT12 interactions

KRT2 KRT3 KRT5 KRT76 KRT75

1.21e-0824655int:KRT12
InteractionKRT81 interactions

KRT26 KRT24 KRT27 KRT81 KRT28 KRT25

1.81e-0853656int:KRT81
InteractionKRT39 interactions

KRT2 KRT3 KRT76 KRT81 KRT83 KRT86

3.50e-0859656int:KRT39
InteractionKRT4 interactions

KRT4 KRT26 KRT24 KRT27 KRT28 KRT25

4.74e-0862656int:KRT4
InteractionKRT2 interactions

KRT2 KRT5 KRT10 KRT24 KRT75 KRT27 KRT28 PAN2 KRT25

6.43e-08236659int:KRT2
InteractionKRT18 interactions

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT75 KRT81 PAN2 KRT79 BIRC6

8.99e-084196511int:KRT18
InteractionKRT17 interactions

KRT2 KRT5 KRT10 KRT76 KRT75 KRT27 HRNR FLG2 KRT79

1.13e-07252659int:KRT17
InteractionKRT74 interactions

KRT5 KRT26 KRT24 KRT27 KRT25

1.20e-0737655int:KRT74
InteractionKRT40 interactions

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 ZFHX3 KRT79

1.28e-074346511int:KRT40
InteractionKRT7 interactions

KRT2 KRT5 KRT10 KRT76 KRT75 KRT27

2.22e-0780656int:KRT7
InteractionPRPH interactions

KRT2 KRT3 KRT5 KRT10 KRT76 KRT24 KRT75 KRT27

2.96e-07204658int:PRPH
InteractionKRT77 interactions

KRT2 KRT5 KRT10 KRT75 KRT27 KRT25

6.57e-0796656int:KRT77
InteractionHEXIM1 interactions

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 KRT24 KRT75 KRT27 KRT28 HRNR KRT79 KRT25

9.79e-079136514int:HEXIM1
InteractionZUP1 interactions

KRT2 KRT3 KRT4 KRT5 KRT10 HRNR FLG2

1.45e-06174657int:ZUP1
InteractionLARP7 interactions

KRT2 KRT3 KRT4 KRT5 KRT26 KRT10 KRT76 IRS4 KRT75 KRT27 KRT28 HRNR FLG2 KRT79 KRT25

1.89e-0611136515int:LARP7
InteractionCUL2 interactions

KRT2 KRT5 KRT10 KRT76 IRS4 KRT24 KRT75 KRT27 NUP214 HRNR FLG2

2.68e-065916511int:CUL2
InteractionCRK interactions

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 IRS4 KRT24 KRT79

2.78e-06370659int:CRK
InteractionKRT86 interactions

KRT76 KRT27 KRT28 KRT86 KRT25

4.33e-0675655int:KRT86
InteractionDES interactions

KRT2 KRT3 KRT5 KRT10 KRT76 KRT75

1.19e-05158656int:DES
InteractionWASHC1 interactions

KRT3 KRT26 KRT76 KRT75 KRT28

1.31e-0594655int:WASHC1
InteractionCEP57 interactions

KRT4 IRS4 KRT75 KRT83 KRT86 HRNR

1.52e-05165656int:CEP57
InteractionEVPL interactions

KRT2 KRT5 KRT10 LORICRIN PI4KA

2.35e-05106655int:EVPL
InteractionDPRX interactions

ZFHX3 HRNR FLG2

2.52e-0518653int:DPRX
InteractionKRT10 interactions

KRT2 KRT5 KRT10 KRT76 KRT75 PAN2

3.09e-05187656int:KRT10
InteractionCOPS6 interactions

KRT2 KRT5 KRT10 KRT76 KRT24 KRT75 RAD54B ZFHX3

4.85e-05408658int:COPS6
InteractionTRIML2 interactions

KRT24 KRT75 KRT27 ZFHX3

5.76e-0565654int:TRIML2
InteractionRNF8 interactions

KRT2 KRT3 KRT5 KRT10 ZBTB10 HRNR FLG2 CTRL

6.05e-05421658int:RNF8
InteractionDPPA3 interactions

KRT76 KRT27 NUP214 NUP58

6.48e-0567654int:DPPA3
InteractionKRT83 interactions

KRT27 KRT83 UBR3 KRT25

6.87e-0568654int:KRT83
InteractionOIP5 interactions

KRT3 KRT75 KRT27 KRT81 KRT83 KRT86

7.07e-05217656int:OIP5
InteractionTRIM54 interactions

KRT3 KRT4 KRT76 KRT75 ZFHX3 NUP58 KRT79

7.69e-05321657int:TRIM54
InteractionMEPCE interactions

KRT2 KRT5 KRT26 KRT10 KRT76 KRT75 KRT27 KRT28 HRNR KRT79 KRT25

8.61e-058596511int:MEPCE
InteractionC1orf216 interactions

KRT76 KRT24 KRT75 KRT27

9.08e-0573654int:C1orf216
InteractionPIK3R2 interactions

KRT2 KRT4 KRT5 KRT10 IRS4 KRT79

9.75e-05230656int:PIK3R2
InteractionUSHBP1 interactions

KRT26 KRT75 KRT27 KRT28 ZFHX3 KRT79

1.18e-04238656int:USHBP1
InteractionLCA5L interactions

KRT76 KRT75 KRT81

1.22e-0430653int:LCA5L
InteractionCCDC146 interactions

KRT26 KRT24 KRT27 KRT86

1.43e-0482654int:CCDC146
InteractionUBASH3B interactions

KRT2 KRT4 KRT5 KRT10 KRT79

1.53e-04157655int:UBASH3B
InteractionKIFC3 interactions

KRT3 KRT4 KRT5 KRT26 KRT76 KRT75

1.61e-04252656int:KIFC3
InteractionKRT78 interactions

KRT26 KRT24 KRT27 KRT25

1.79e-0487654int:KRT78
InteractionNUP58 interactions

KRT27 KRT28 NUP214 NUP58

2.23e-0492654int:NUP58
InteractionDCUN1D1 interactions

KRT2 KRT5 KRT10 KRT24 KRT75 FLG2

2.57e-04275656int:DCUN1D1
InteractionRLIM interactions

KRT2 KRT5 KRT10 IRS4 KRT24 HRNR FLG2

2.63e-04392657int:RLIM
InteractionHGS interactions

KRT3 KRT26 KRT76 KRT24 KRT75 KRT27 KRT86 KRT25

2.68e-04523658int:HGS
InteractionNPHP3 interactions

KRT2 KRT5 KRT10

3.36e-0442653int:NPHP3
InteractionEFNA1 interactions

KRT2 KRT5 KRT10 HRNR

3.43e-04103654int:EFNA1
InteractionEPPK1 interactions

KRT3 KRT4 KRT75 KRT27 KRT86

3.60e-04189655int:EPPK1
InteractionCUL4A interactions

KRT2 KRT10 KRT76 KRT24 KRT75 PI4KA HIC2 HRNR FLG2 GPT2

3.82e-048546510int:CUL4A
InteractionWTAP interactions

KRT2 KRT5 KRT10 HRNR FLG2

4.06e-04194655int:WTAP
InteractionEFNA3 interactions

KRT2 KRT5 KRT10 HRNR

4.11e-04108654int:EFNA3
InteractionCYLD interactions

KRT2 KRT4 KRT5 KRT10 ZNF609 KRT27 NUP214 HRNR FLG2 KRT25

4.35e-048686510int:CYLD
InteractionAP2M1 interactions

KRT2 KRT3 KRT5 KRT10 BMP2K DGKI KRT79

4.60e-04430657int:AP2M1
InteractionDDX39B interactions

KRT2 KRT4 KRT5 KRT10 KRT86 HRNR FLG2 GPT2

4.77e-04570658int:DDX39B
InteractionPCM1 interactions

KRT2 KRT24 KRT81 TRO KRT83 KRT86 PAN2

4.86e-04434657int:PCM1
InteractionDIRAS2 interactions

KRT2 KRT10 HRNR

6.32e-0452653int:DIRAS2
InteractionINPPL1 interactions

KRT2 KRT3 KRT5 KRT10 KRT79

6.34e-04214655int:INPPL1
InteractionDDX24 interactions

KRT2 KRT5 KRT10 CHIA KRT75 KRT83 HRNR FLG2

6.39e-04596658int:DDX24
InteractionIFFO1 interactions

KRT2 KRT81 KRT86

7.06e-0454653int:IFFO1
InteractionPHF21A interactions

IRS4 KRT27 ZFHX3 NUP214 NUP58 BIRC6

8.26e-04343656int:PHF21A
InteractionFBP1 interactions

KRT2 KRT5 KRT10 OAS3 HRNR FLG2

8.90e-04348656int:FBP1
InteractionARF5 interactions

KRT2 KRT5 KRT10 HRNR FLG2

8.95e-04231655int:ARF5
InteractionNPHP4 interactions

KRT2 KRT5 KRT10 IRS4 PI4KA

9.84e-04236655int:NPHP4
InteractionCIBAR1 interactions

KRT5 KRT10 NUP214 HRNR

1.00e-03137654int:CIBAR1
InteractionKRT85 interactions

KRT26 KRT27 KRT25

1.01e-0361653int:KRT85
InteractionEFNA4 interactions

KRT2 KRT5 KRT10 KRT83 SPCS2

1.04e-03239655int:EFNA4
CytobandEnsembl 112 genes in cytogenetic band chr12q13

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 PAN2 KRT79

2.89e-114236711chr12q13
Cytoband12q13.13

KRT2 KRT3 KRT4 KRT5 KRT76 KRT79

7.15e-106767612q13.13
Cytoband17q21.2

KRT26 KRT24 KRT27 KRT28 KRT25

6.39e-087067517q21.2
Cytoband12q13

KRT75 KRT81 KRT83 KRT86

3.74e-067167412q13
CytobandEnsembl 112 genes in cytogenetic band chr17q21

KRT26 KRT10 KRT24 KRT27 KRT28 KRT25

6.80e-05473676chr17q21
CytobandEnsembl 112 genes in cytogenetic band chr1q21

SEMA6C LCE4A LORICRIN HRNR FLG2

3.18e-04404675chr1q21
Cytoband1q21.3

LCE4A HRNR FLG2

6.86e-041176731q21.3
Cytoband21q22.1

KRTAP13-1 KRTAP15-1

1.50e-033967221q22.1
Cytoband7p15.2

HOXA11 EVX1

1.82e-03436727p15.2
Cytoband2q31.1

SP9 UBR3

6.77e-03846722q31.1
CytobandEnsembl 112 genes in cytogenetic band chr7p15

HOXA11 EVX1

9.65e-03101672chr7p15
GeneFamilyKeratins, type II

KRT2 KRT3 KRT4 KRT5 KRT76 KRT75 KRT81 KRT83 KRT86 KRT79

5.21e-20274810609
GeneFamilyKeratins, type I

KRT26 KRT10 KRT24 KRT27 KRT28 KRT25

9.13e-1128486608
GeneFamilyEF-hand domain containing|S100 fused type protein family

HRNR FLG2

1.44e-0474821350
GeneFamilyNucleoporins

NUP214 NUP58

3.25e-03324821051
GeneFamilyPotassium voltage-gated channels

KCNC4 KCNQ4

5.05e-0340482274
GeneFamilyHOXL subclass homeoboxes

HOXA11 EVX1

8.41e-0352482518
CoexpressionHOLLERN_SQUAMOUS_BREAST_TUMOR

KRT5 KRT10 KRT75 KRT27 KRT81 KRT83 KRT86 HRNR KRTAP13-1 KRT79 KRTAP15-1 KRT25

1.22e-132046612MM966
CoexpressionHOLLERN_SQUAMOUS_BREAST_TUMOR

KRT5 KRT10 KRT75 KRT27 KRT81 KRT83 KRT86 HRNR KRT79 KRTAP15-1 KRT25

5.89e-131736611M650
CoexpressionLUI_THYROID_CANCER_CLUSTER_2

TOB2 PI4KA HECTD4 PAN2 HIC2

7.75e-0843665M7343
CoexpressionNIKOLSKY_BREAST_CANCER_17Q11_Q21_AMPLICON

KRT26 KRT10 KRT24 KRT27 KRT28 KRT25

1.03e-06132666M3434
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

KRT75 KRT27 KRT81 TRO KRT83 KRT86 KRTAP13-1 KRT79 KRTAP15-1 KRT25

4.96e-066506610MM1042
CoexpressionMARTINEZ_TP53_TARGETS_DN

KRT75 KRT27 KRT81 TRO KRT83 KRT86 KRTAP13-1 KRT79 KRTAP15-1 KRT25

5.60e-066596610MM1040
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

KRT75 KRT27 KRT81 TRO KRT83 KRT86 KRT79 KRTAP15-1 KRT25

2.14e-05610669M3854
CoexpressionMARTINEZ_TP53_TARGETS_DN

KRT75 KRT27 KRT81 TRO KRT83 KRT86 KRT79 KRTAP15-1 KRT25

2.29e-05615669M8673
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K27ME3

HOXA11 KRT81 KRT83 KRT86 EVX1 MFSD6L

7.78e-05282666MM822
CoexpressionGSE22935_UNSTIM_VS_24H_MBOVIS_BCG_STIM_MYD88_KO_MACROPHAGE_DN

TOB2 CHIA KRT24 CTRL ZNF654

1.51e-04200665M7771
CoexpressionGSE11961_UNSTIM_VS_ANTI_IGM_AND_CD40_STIM_6H_FOLLICULAR_BCELL_UP

KRT2 BMP2K GNPTAB RAD54B BIRC6

1.51e-04200665M9333
CoexpressionAtlasskin

KRT2 KRT3 KRT5 KRT10 LCE4A PPP1R14C LORICRIN FLG2 KRT79

7.60e-06456639skin
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_100

KRT5 IRS4 LORICRIN

8.85e-0614633DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_200

KRT4 KRT5 IRS4 LORICRIN EVX1 NUP214

9.47e-06165636gudmap_developingLowerUrinaryTract_e14.5_ urethra_200
CoexpressionAtlasbreast

KRT27 KRT81 KRT28 KRT79 KRT25

3.36e-05124635breast
CoexpressionAtlasthyroid gland

IRS4 PPP1R14C KRT83 KRT86 DGKI SNTB1

7.77e-05240636thyroid gland
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#1_top-relative-expression-ranked_500

KRT4 KRT5 KRT75 LORICRIN

8.51e-0578634gudmap_developingLowerUrinaryTract_e14.5_ urethra_500_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000

KRT4 KRT5 IRS4 KRT75 LORICRIN EVX1 NUP214 NUP58 CAMTA1 BIRC6

1.21e-048066310gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_200

KRT4 KRT5 LORICRIN

1.27e-0433633DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_top-relative-expression-ranked_100

KRT4 KRT5 IRS4 LORICRIN

1.30e-0487634gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_100

KRT4 KRT5 IRS4 LORICRIN

1.42e-0489634DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#4_top-relative-expression-ranked_1000

IRS4 KRT75 LORICRIN EVX1

1.48e-0490634gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_500

KRT4 KRT5 IRS4 KRT75 LORICRIN EVX1 NUP214

1.98e-04407637gudmap_developingLowerUrinaryTract_e14.5_ urethra_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#4_top-relative-expression-ranked_200

KRT4 KRT5 LORICRIN

2.11e-0439633gudmap_developingLowerUrinaryTract_e14.5_ urethra_200_k4
CoexpressionAtlasUniversalReference_WholeMouseP1_top-relative-expression-ranked_500

KRT4 KRT5 KRT10 KRT27 LORICRIN CTRL KRT25

2.65e-04427637Facebase_ST1_Univ_500
ToppCellTCGA-Skin-Primary_Tumor|TCGA-Skin / Sample_Type by Project: Shred V9

KRT5 KRT10 KRT75 DSG3 LORICRIN FLG2

4.22e-07190676e2b26a03c6ab24d9b0f4150c47597be37767d86e
ToppCellTCGA-Skin-Primary_Tumor-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

KRT5 KRT10 KRT75 DSG3 LORICRIN FLG2

4.22e-0719067601fb45add4661bc86cd0a34fac35177907152dbb
ToppCellTCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

KRT5 KRT10 KRT75 DSG3 LORICRIN FLG2

4.22e-071906763188c7bd225cbcf46a21e2fb784336cdd9665995
ToppCellfacs-Skin|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT10 KRT24 DSG3 PPP1R14C CAMTA1

4.35e-07191676ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-6|TCGA-Skin / Sample_Type by Project: Shred V9

KRT26 KRT28 KRT83 KRTAP13-1 KRT25

2.76e-06146675522c32103c24fc26836bb5b642083904682d9292
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT2 CPA5 DSG3 PPP1R14C KRT79

5.32e-0616767569caf4a53805f8c104d7dd8f88665fc992e23720
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT26 IRS4 CPA5 KRT27

7.20e-068267415bc417aaace2b1d680904a622fe76e95083c9ff
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT26 IRS4 CPA5 KRT27

7.20e-0682674697e1da3095c8483b8181b290fa5417bdc9cee54
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT26 IRS4 CPA5 KRT27

7.20e-068267473349906bcc8d1a40dc03df7a490a963e85564f2
ToppCell10x5'v1-week_14-16-Lymphocytic_NK-T_NK-ILC_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

KRT2 KRT81 KRT83 KRT86 KRT25

7.66e-06180675a999a6d219a8e58a8b63802ddf8c95ffaab9cfa0
ToppCelldroplet-Skin|droplet / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT10 DSG3 PPP1R14C KRT79

8.75e-06185675657fd191ed160f8620d57b33820ec7222806f289
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT3 KRT4 KRT5 KRT76 DSG3

1.16e-0519667503de28e1c963e99623e8b0e33bf2e8ef67dc3baa
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-leukocyte|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT3 KRT4 KRT5 KRT76 DSG3

1.19e-05197675e621d4f9d4ba5e3ef17d2b477e5e14ea0251147e
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KRT3 TICRR KRT5 DSG3 RAD54B

1.21e-05198675f088badb90c6c2d916195f5649eda102119c9ac6
ToppCelldroplet-Tongue-nan-24m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT81 KRT83 KRT86 KRTAP13-1

1.85e-05104674a4ae3cae44aac8b6e0d14896f9acab44f0cc97c4
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-2|TCGA-Cervix / Sample_Type by Project: Shred V9

KRT26 KRT27 KRT28 KRT25

3.13e-05119674d21877baa088440a1e1902bbeb667b977475437a
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-10|TCGA-Bladder / Sample_Type by Project: Shred V9

KRT26 KRT81 KRTAP13-1 KRT25

4.30e-051296746a201c6344a015e5cf2f79ccf397fd7ad66b6768
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Cabp7_(Retrosplenial_areas,_subiculum,_presubiculum,_Cabp7+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

KRT2 KRT27 KRT79

8.72e-055767369d867b775be8e68d274c149e406cc306cee7f63
ToppCellPosterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Tshz2-Excitatory_Neuron.Slc17a7-Slc17a6.Tshz2-Cabp7_(Retrosplenial_areas,_subiculum,_presubiculum,_Cabp7+)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

KRT2 KRT27 KRT79

8.72e-05576736bf3886d5ebe6bf65a503648ac455415cbb4fc6c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KCNC4 PLCL2 DGKI SNTB1

9.45e-05158674debebc8534a80e5500051f6fd352dc201585968d
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-4|TCGA-Stomach / Sample_Type by Project: Shred V9

KRT4 KRT5 KRT24 DSG3

1.07e-041636746a12b802cb181f979ebc72674f3626fb855024e3
ToppCell10x5'-GI_small-bowel-Lymphocytic_NK-NK_CD56bright_CD16-|GI_small-bowel / Manually curated celltypes from each tissue

KRT81 KRT83 KRT86 ZFHX3

1.09e-0416467436e64e4f717dd59b352c20ff9742ca1e232342bb
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHIA PPP1R14C MFSD6L HERC3

1.14e-04166674575c325db88d6909cdf0d5e664bd9098b89d4401
ToppCellTCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck-Head_and_Neck_normal_tissue-6|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

KRT3 KRT4 KRT76 KRTAP13-1

1.17e-041676744a533972a0f40fff82dccf8e64716cb34f75736e
ToppCellPND07-Epithelial-Epithelial_Airway-Basal-Basal-Basal_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT4 KRT5 DSG3 SNTB1

1.20e-04168674f150beee37e0252951a88adcd9e3f0a22e5cfdd9
ToppCell(7)_MNP-(7)_DC_activated|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)

BMP2K PPP1R14C LORICRIN FLG2

1.25e-041706744ab495b38a071fa8207331df2ce0d78a2dcd034e
ToppCellCOPD-Lymphoid-ILC_A|Lymphoid / Disease state, Lineage and Cell class

KRT81 KRT83 KRT86 PLCL2

1.34e-041736744a0043b29f8ede5a74bdb38cbf2c70e12b25e130
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Myeloid-macrophage|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 DSG3 HRNR

1.37e-0417467484f2ffe867f22d2fa79f28737a0aa42bdf2f4804
ToppCellfacs-Trachea-nan-18m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT4 KRT5 KRT27 SNTB1

1.40e-04175674eb87275da6f61ecb4fbc89421dfd27bead1e0f48
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nxph3|Hippocampus / BrainAtlas - Mouse McCarroll V32

KRT75 KRT81 KRT86

1.41e-0467673b80bdd122a0284611161c40ec7a9c893dc8de4de
ToppCellFF-Differ-KC|World / shred by cell class for mouse tongue

KRT75 KRT81 KRT83 KRT86

1.53e-041796741526a130565a97c291a25a7a988089bffc1515c1
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 KRT75 DSG3

1.59e-04181674a5e770b5b5d57cbac18560828e89f7c96b687743
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 KRT75 DSG3

1.59e-04181674504b1af1951a7a20ef5db69d84c20630ec64095b
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 KRT75 DSG3

1.59e-04181674a55ec36d2393f7a376feb42b22aee75dfdf4c383
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KRT81 KRT83 KRT86 KRT25

1.66e-041836742c0b1265af2bca2c378ff7104bce337c98053b5e
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 DSG3 RAD54B MFSD6L

1.66e-04183674bbf27d2f4369031fadacacd6c432c06b1ec5abdb
ToppCellwk_08-11-Hematologic_Lymphocytic-T_&_ILC-ILCP|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

KRT81 KRT83 KRT86 KRT25

1.66e-04183674797eb968c57e48db33ff8e2236ee22e9425c4676
ToppCellControl-Lymphoid-ILC_A|World / Disease state, Lineage and Cell class

HOXA11 KRT81 KRT86 PLCL2

1.77e-041866747bc939bf4e71bb4c6409b862c1f6c547d775e089
ToppCellTCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-6|TCGA-Skin / Sample_Type by Project: Shred V9

KRT10 KRT75 DSG3 FLG2

1.81e-041876742ca7928baf0c5e61f7294ed05e6e6f0e0adf9d3f
ToppCellNS-critical-d_07-13-Epithelial-IRC-IFNG_responsive_cell|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KRT5 KRT24 DGKI OAS3

1.84e-041886746ee2e7fa80f48e4a7f3321b0776a4f697469bc61
ToppCellNS-moderate-d_07-13-Lymphoid-NKT|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TICRR KRT81 KRT83 KRT86

1.88e-0418967424519fa45e7d1c2fb397e9ffe00ecb7f7d4cefd8
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KRT81 KRT83 KRT86 KRT25

1.92e-04190674af39d2a46d9502cec69a69b7e8ffef78fc8311c3
ToppCelldroplet-Tongue-nan-3m-Epithelial-filiform|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT81 KRT83 KRT86 KRTAP13-1

1.92e-04190674251e3a33041023bfc4b547c7eb68cfb8f421636f
ToppCelldroplet-Tongue-Unstain-18m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT81 KRT86 KRTAP13-1

2.00e-0419267445ff9555f9a9fccc650885956005b2e5b4820a56
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT4 KRT5 PPP1R14C CTRL

2.12e-0419567417c4d3b59cd0d79ce9ae5dde95586f3e923db16f
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT4 KRT5 KRT24 DSG3

2.12e-0419567424d226f89dd337c22728688e4b40ca082a0e1fe1
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT4 KRT5 PPP1R14C CTRL

2.12e-0419567466caa5c063184e7d3d653c8f6c289555cb36fa82
ToppCelldroplet-Tongue|droplet / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT4 KRT5 KRT24 DSG3

2.12e-04195674e460b09ae354b579ce552acebdaa5877a6e62343
ToppCellfacs-Tongue|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT4 KRT5 KRT24 DSG3

2.12e-0419567477128895db9221a64a171082d468ebcd6380c936
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT4 KRT5 PPP1R14C CTRL

2.12e-04195674ed74c113074fb5d3c42f2330b0e6042d32c3611a
ToppCellBronchus_Control_(B.)-Epithelial-TX-AT1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

DGKI UBR3 GPT2 SNTB1

2.20e-04197674f7ef62d78336812573148f8bfce401877ec4e29c
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-leukocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT4 KRT5 KRT76 DSG3

2.20e-04197674d968d7d5608b175bb567ea3a315bf473ec3be459
ToppCellBiopsy_Control_(H.)-Epithelial-Basal|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

KRT4 KRT5 DGKI GPT2

2.29e-041996746a274a5db02c55bbf31d602b9d5c8394241acdca
ToppCell(00)_Basal-(1)_GFP|(00)_Basal / shred by cell type by condition

KRT4 KRT5 KRT24 PPP1R14C

2.29e-04199674105b15157f35df3fdf857e306f11e4e8200e05d4
ToppCellSigmoid-(1)_T_cell-(17)_gd_T|Sigmoid / shred on region, Cell_type, and subtype

KRT81 KRT86 GNPTAB PLCL2

2.33e-04200674a02e5a69f7101accd8f1394ab1c8007e211187f7
ToppCellKidney-Keratinocytes|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.

KRT2 KRT5 KRT10 DSG3

2.33e-0420067441d83faa9f45ee7ea2ab19be8ecc6d2c5ac7fe5d
ToppCellBronchus_Control_(B.)-Epithelial-TX-Basal_2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

KRT4 KRT5 KRT24 DSG3

2.33e-042006740fa3340d945f00ef55c7603476d51bd8346e82c2
ToppCellSigmoid-T_cell-gd_T|Sigmoid / Region, Cell class and subclass

KRT81 KRT86 GNPTAB PLCL2

2.33e-04200674eef4df008cccdf6297b1c90c986c68793afd8b78
ToppCellSkin-Keratinocytes|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.

KRT2 KRT5 KRT10 PPP1R14C

2.33e-0420067459d72395199bc30df0e811fbc99149694e208860
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Ngfr_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT2 KRT76 OAS3

2.57e-04826731ed7d7f70f00d6e280cd59c54e710bb724c8b50b
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Ngfr_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT2 KRT76 OAS3

2.57e-0482673a5d3c5b7012d8ca7418670242d22aad3ed8c5191
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT2 KRT76 OAS3

2.57e-0482673cefd8c6f60ef27fb8823faddca1cf8bbd636f474
ToppCellStriatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Gad1Gad2-Th.Trh_(Th+_interneuron)-|Striatum / BrainAtlas - Mouse McCarroll V32

KRT26 IRS4 KRT24

2.86e-048567386c5d71b66ff55c44d2d457865dda72e07e5ec53
ToppCellStriatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Gad1Gad2-Th.Trh_(Th+_interneuron)|Striatum / BrainAtlas - Mouse McCarroll V32

KRT26 IRS4 KRT24

2.86e-048567367336aa7ec02b64595ce7d5222d43cead92eb52e
ToppCellStriatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th|Striatum / BrainAtlas - Mouse McCarroll V32

KRT26 IRS4 KRT24

2.86e-0485673a7a5d82924cd4a41ab87b1abf13143635882a4b2
ToppCellGlobus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT4 KRT75 KRT79

3.27e-0489673606fbee8326e55fed7b1fd96d3ae80c0b0cfa3c8
ToppCellGlobus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Acta2_(Mural.Rgs5Acta2.Acta2)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT4 KRT75 KRT79

3.27e-0489673018ea3fd99eca755c1656c08b35d48e5085788d1
ToppCellGlobus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Acta2_(Mural.Rgs5Acta2.Acta2)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT4 KRT75 KRT79

3.27e-0489673eeafa9e27d0d22242a2f91774ae78df104337696
ComputationalGenes in the cancer module 68.

KRT2 KRT4 KRT5 KRT86

1.34e-0626354MODULE_68
ComputationalKeratin.

KRT2 KRT4 KRT5 KRT86

1.34e-0626354MODULE_298
ComputationalNeighborhood of BRCA1

HOXA11 KRT2 LORICRIN KRT86 HIC2 CTRL

1.81e-04263356MORF_BRCA1
ComputationalNeighborhood of ATF2

KRT2 LORICRIN KRT83 KRT86 CAMTA1 CTRL

6.12e-04330356MORF_ATF2
ComputationalNeighborhood of MSH3

HOXA11 KRT2 KRT86 HIC2 CTRL

1.06e-03243355MORF_MSH3
ComputationalIntermediate filaments and MT.

KRT2 KRT4 KRT5

1.37e-0368353MODULE_438
Drugteleocidin B

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT24 KRT75 KRT81 KRT83 KRT86

6.06e-141236611CID000072425
Drugsulfur mustard

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT24 KRT75 KRT81 KRT83 KRT86

1.13e-131306611CID000010461
Drughomocysteine thiolactone

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT24 KRT75 KRT81 KRT83 KRT86

1.23e-131316611CID000107712
Drugal-Badry

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT24 KRT75 KRT81 KRT83 KRT86

1.58e-121656611CID000004545
Drug1-2q

KRT2 KRT3 KRT4 KRT5 KRT10 KRT24 KRT75 KRT81 KRT83 KRT86 IREB2 SNTB1

3.72e-112896612CID000011820
DrugAC1L9MJT

KRT2 KRT3 KRT4 KRT5 KRT10 KRT24 KRT75 KRT81 KRT83 KRT86

2.01e-101926610CID000448959
DrugVelcade (bortezomib

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT24 KRT75 KRT81 KRT83 KRT86 CTRL

7.18e-103746612CID000093860
Drugadenosine 3',5'-cyclic phosphate

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT24 KRT75 KCNC4 KCNQ4 KRT81 KRT83 KRT86

1.69e-069076613CID000000274
Drugbutyrate

KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT24 KRT75 KRT81 KRT83 KRT86 OAS3

1.82e-067676612CID000000264
Drugtebuquine

KRT81 KRT83

8.28e-062662CID000071991
Drug3,5-di-O-galloylquinic acid

KRT81 KRT83

8.28e-062662CID000460896
Drugmelicopicine

KRT81 KRT83

8.28e-062662CID000101253
DrugHelveticoside [630-64-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A

TOB2 ZNF609 TRO NUP58 CTRL ZNF654

8.99e-061676666047_UP
Drugdithranol

KRT2 KRT10 KRT75

1.84e-0518663CID000002202
DrugATBI

KRT81 KRT83 KRT86

1.84e-0518663CID000505862
DrugAmbroxol hydrochloride [23828-92-4]; Up 200; 9.6uM; PC3; HT_HG-U133A

KRT10 IRS4 CHIA BMP2K DSG3 SNTB1

2.29e-051976666719_UP
DrugPhthalylsulfathiazole [85-73-4]; Up 200; 10uM; MCF7; HT_HG-U133A

HOXA11 KRT2 KRT75 KRT83 HIC2 SNTB1

2.36e-051986665614_UP
DrugCK 6

KRT3 KRT4 KRT5 KRT10

2.43e-0558664CID000447960
Drugtryptophan ethyl ester

KRT4 KRT5

2.48e-053662CID000081996
Drugsulfonamide-3

KRT81 KRT83

2.48e-053662CID009847197
Drugpyriproxyfen

KRT81 KRT83 KRT86

3.95e-0523663CID000091753
Drugsalsalate

CHIA KRT81 KRT83 KRT86

4.05e-0566664CID000005161
Drugbeta-damascenone

KRT10 LORICRIN HRNR

4.51e-0524663ctd:C075388
Druglactucin

KRT81 KRT83

4.95e-054662CID000442266
DrugLactupicrin

KRT81 KRT83

4.95e-054662CID000174880
DrugAC1L7GLZ

DSG3 NUP214

4.95e-054662CID000360406
Drugethylnylestradiol

HOXA11 KRT2 KRT3 KRT4 KRT5 KRT10 KRT76 KRT24 KRT75 KRT81 KRT83 KRT86 CTRL

5.24e-0512516613CID000003285
Drugethylene

CHIA DSG3 KRT81 KRT83 IREB2

5.79e-05142665CID000006325
Drugolomoucine II

KRT4 KRT5 KRT10

6.47e-0527663CID005494414
Drugvariolin B

KRT81 KRT83 CTRL

9.87e-0531663CID009817550
DrugCD367

KRT4 KRT5 KRT10

1.19e-0433663CID000119342
Drugdictamnine

KRT81 KRT83

1.23e-046662CID000068085
Drugskimmianine

KRT81 KRT83

1.23e-046662CID000006760
Drugarborinine

KRT81 KRT83

1.23e-046662CID005281832
DrugStrophantine octahydrate [11018-89-6]; Up 200; 5.4uM; PC3; HT_HG-U133A

TOB2 ZBTB10 HIC2 NUP58 ZNF654

1.24e-041676656680_UP
DrugDigoxigenin [1672-46-4]; Up 200; 10.2uM; PC3; HT_HG-U133A

TOB2 ZBTB10 HIC2 NUP58 ZNF654

1.35e-041706654680_UP
DrugStrophantine octahydrate [11018-89-6]; Up 200; 5.4uM; HL60; HT_HG-U133A

TOB2 KRT10 ZNF609 HIC2 NUP58

1.51e-041746651302_UP
DrugTGQA

KRT81 KRT83

1.72e-047662CID000127406
DiseaseBeaded hair

KRT81 KRT83 KRT86

9.28e-093633cv:C0546966
DiseaseMONILETHRIX

KRT81 KRT83 KRT86

9.28e-093633158000
Diseasemonilethrix (is_implicated_in)

KRT81 KRT83 KRT86

9.28e-093633DOID:0050472 (is_implicated_in)
DiseaseMonilethrix

KRT81 KRT83 KRT86

3.70e-084633C0546966
Diseasehair disease (is_implicated_in)

KRT81 KRT86

4.49e-062632DOID:421 (is_implicated_in)
Diseasehypertension

HOXA11 TICRR HECTD4 ZBTB10 OAS3 SNTB1

4.99e-05307636EFO_0000537
DiseaseErythrokeratodermia variabilis

LORICRIN KRT83

9.36e-057632C0265961
Diseasealcohol consumption measurement, alcohol drinking

HECTD4 OAS3

2.92e-0412632EFO_0004329, EFO_0007878
DiseaseContact Dermatitis

KRT2 KRT4 KRT10

4.78e-0471633C0011616
DiseaseContact hypersensitivity

KRT2 KRT4 KRT10

4.78e-0471633C0162351
Diseasecognitive decline measurement

KRT5 KRT26 KRT24 KRT28 DGKI KRT25

5.95e-04486636EFO_0007710
Diseasesmoking cessation

PLCL2 IREB2 ZFHX3 CAMTA1 BIRC6

6.55e-04325635EFO_0004319
Diseasesmoking behaviour measurement

TOB2 PLCL2 IREB2 CAMTA1

1.31e-03222634EFO_0005671

Protein segments in the cluster

PeptideGeneStartEntry
ACGGNSLGSYSASQG

GPT2

141

Q8TD30
CAGGAGASSCQGDSG

CTRL

201

P40313
GSGSGNGGSQAQCAS

CAMTA1

1011

Q9Y6Y1
SGSDSSVGARACFGG

BIRC6

2881

Q9NR09
GGDSGVLGANGASCS

BHLHA9

31

Q7RTU4
SGGGGSQGTLACSAS

EVX1

166

P49640
GGSSGGSGFCAVRAN

CHIA

421

Q9BZP6
GCGSGGSSVGVRVFA

BMP2K

31

Q9NSY1
DFSSGRCFQLGGGST

RAD54B

201

Q9Y620
GSCDSGELGRNSGTF

IREB2

176

P48200
SSGGSFCNSGGGLGS

KRT26

51

Q7Z3Y9
GGACGFRSGAGSFGS

KRT76

41

Q01546
SRAGGFGGGRSSCGF

KRT76

76

Q01546
ASGFGAATGVGICSS

DSG3

746

P32926
AYRGAGGSSFCSSGD

PAN2

636

Q504Q3
SGQSSGFGQCGSGSG

FLG2

486

Q5D862
GFGQCGSGSGQSSGF

FLG2

491

Q5D862
AGSSACGGSVAGSEF

KRT28

31

Q7Z3Y7
AGSEFSCALGGGLGS

KRT28

41

Q7Z3Y7
SFSRGSSGGGCFGGS

KRT10

56

P13645
GDCSGNSGGSRYIAG

GNPTAB

466

Q3T906
GGVFTFGAGSCGQLG

HERC3

261

Q15034
GGGFRGFSSGSAVVS

KRT2

16

P35908
RAGGFGGGRSSCAFA

KRT3

76

P12035
SGFSASSGRGLGVGF

KRT5

551

P13647
GNSTTVCGGGAASFG

KRT79

471

Q5XKE5
GSHSVCGGFRAGSCG

KRT86

46

O43790
AGSCGRSFGYRSGGV

KRT86

56

O43790
SGGAGRCSSGGFGSR

KRT4

36

P19013
AGSRQGACFGGAGGF

KRT4

66

P19013
PGSGSGSACGQRSSA

KCNQ4

61

P56696
SGFGGNGSNSNPCSE

CPA5

276

Q8WXQ8
GSGCSLGSFVGGFVV

MFSD6L

501

Q8IWD5
SHQSSGRGQCGSGSG

HRNR

186

Q86YZ3
GGGCSGSGSSASRGF

PI4KA

16

P42356
SRCGLGGSSAQGFRG

KRT24

31

Q2M2I5
GGSSAQGFRGGASSC

KRT24

36

Q2M2I5
QGFRGGASSCSLSGG

KRT24

41

Q2M2I5
VSGFGRGSGFCGSSR

KRT24

96

Q2M2I5
IGSGFSCAFGGSSSA

KRT27

41

Q7Z3Y8
GLGGGSASCAAFTGN

KRT27

61

Q7Z3Y8
GGTSFGTGNSCGISG

KRT25

26

Q7Z3Z0
GTGNSCGISGIGSGF

KRT25

31

Q7Z3Z0
CGISGIGSGFSSAFG

KRT25

36

Q7Z3Z0
TFSSGGGSVASQGFG

NUP214

1946

P35658
SGCFSSGGGGSGCFS

LORICRIN

101

P23490
SGCFSSGGGGFSGQA

LORICRIN

141

P23490
SGGGGFSGQAVQCQS

LORICRIN

146

P23490
SSDSGGGGGCRETAA

HOXA11

191

P31270
GSGGAAAGDQGRFST

HECTD4

2816

Q9Y4D8
CGFFGLGGAASASLG

C18orf15

86

Q96N68
SSGSGAGSCCLGAEG

DGKI

71

O75912
GCGSSGFRSLGYGGC

KRTAP13-1

121

Q8IUC0
SNCYGSGSGQQSGGS

LCE4A

76

Q5TA78
SGSGQQSGGSGCCSG

LCE4A

81

Q5TA78
GLGSLGCGSTGFQSL

KRTAP15-1

101

Q3LI76
FGGCLGNSSGSGCKS

CNTNAP3B

491

Q96NU0
GSHSVCGGFRAGSCG

KRT83

51

P78385
AGSCGRSFGYRSGGV

KRT83

61

P78385
GGFGTSSGFGCSTTG

NUP58

511

Q9BVL2
GSSGRGTALKGGCDS

OAS3

61

Q9Y6K5
AGGASGGGARVFFQS

PPP1R14C

11

Q8TAE6
SSGGNQCSGEGQGSR

IRS4

516

O14654
AGGEAGLGGCSSSTN

HIC2

221

Q96JB3
GTATNGSFCRGAGAG

SNTB1

61

Q13884
SGGVSNGDCSLGVSG

PLCL2

51

Q9UPR0
SGEDGGSKNCFGRSG

MTG2

136

Q9H4K7
GGLAGGSGAANSAFC

SP9

76

P0CG40
AVGCGAGSSSGRGEV

TICRR

1691

Q7Z2Z1
GAGFGGALNTSASFG

TRO

966

Q12816
GCSGAGGASNCGTGS

SPCS2

16

Q15005
GGASNCGTGSGRSGL

SPCS2

21

Q15005
GHSRGFCGAGGSSSR

TMEM131

1191

Q92545
FCGAGGSSSRPSAGS

TMEM131

1196

Q92545
GSCSSVGGASGGERS

ZNF609

1336

O15014
GSGNCGGGVGISSRD

ZNF654

41

Q8IZM8
GSCAGVGGAALFSSS

SEMA6C

371

Q9H3T2
RGGNLCSGGASTAGK

UBR3

1466

Q6ZT12
GGSCSSSRRSGGDGG

ZBTB10

201

Q96DT7
FGGSGAGTCNSSSFD

TOB2

286

Q14106
SLSQLTQGGGACGSG

ZFHX3

146

Q15911
VGSSGSSGGGGCEFF

KCNC4

81

Q03721
CGSSCRSGFGGRASN

KRT75

76

O95678
GSHSVCGGFRAGSCG

KRT81

46

Q14533
AGSCGRSFGYRSGGV

KRT81

56

Q14533