Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	JUN kinase kinase kinase activity	MAP3K11 MAP3K21	3.53e-04	12	47	2	GO:0004706
GeneOntologyMolecularFunction	carbohydrate:monoatomic cation symporter activity	SLC45A1 SLC5A3	7.21e-04	17	47	2	GO:0005402
GeneOntologyMolecularFunction	D-glucose transmembrane transporter activity	SLC45A1 SLC5A3	1.57e-03	25	47	2	GO:0055056
GeneOntologyMolecularFunction	hexose transmembrane transporter activity	SLC45A1 SLC5A3	1.57e-03	25	47	2	GO:0015149
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	MAP3K11 MAP3K21	1.83e-03	27	47	2	GO:0004709
GeneOntologyMolecularFunction	monosaccharide transmembrane transporter activity	SLC45A1 SLC5A3	1.83e-03	27	47	2	GO:0015145
GeneOntologyMolecularFunction	sugar transmembrane transporter activity	SLC45A1 SLC5A3	2.11e-03	29	47	2	GO:0051119
GeneOntologyBiologicalProcess	positive regulation of reactive oxygen species biosynthetic process	ADCY10 GRIN1 SLC5A3	2.78e-05	26	47	3	GO:1903428
Domain	MLK1/MLK2/MLK4	MAP3K11 MAP3K21	3.71e-05	4	47	2	IPR016231
Domain	MAP3K10	MAP3K11 MAP3K21	3.71e-05	4	47	2	IPR015785
Domain	EamA_dom	SLC35G2 SLC35C1	5.53e-04	14	47	2	IPR000620
Domain	EamA	SLC35G2 SLC35C1	5.53e-04	14	47	2	PF00892
Domain	Claudin_CS	CLDN7 CLDN1	1.39e-03	22	47	2	IPR017974
Domain	CLAUDIN	CLDN7 CLDN1	1.39e-03	22	47	2	PS01346
Domain	Claudin	CLDN7 CLDN1	2.25e-03	28	47	2	IPR006187
Domain	PMP22_Claudin	CLDN7 CLDN1	4.55e-03	40	47	2	PF00822
Domain	PMP22/EMP/MP20/Claudin	CLDN7 CLDN1	5.73e-03	45	47	2	IPR004031
Domain	FBOX	FBXO10 FBXL4	7.59e-03	52	47	2	SM00256
Pubmed	Increased expression of claudin-1 and claudin-7 in liver cirrhosis and hepatocellular carcinoma.	CLDN7 CLDN1	1.87e-06	2	48	2	24696415
Pubmed	Polymorphisms in the CLDN1 and CLDN7 genes are related to differentiation and tumor stage in colon carcinoma.	CLDN7 CLDN1	1.87e-06	2	48	2	24479816
Pubmed	Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells.	IRS2 IL4R	1.87e-06	2	48	2	8954948
Pubmed	A Claudin-Based Molecular Signature Identifies High-Risk, Chemoresistant Colorectal Cancer Patients.	CLDN7 CLDN1	1.87e-06	2	48	2	34571860
Pubmed	Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.	IRS2 IL4R	5.59e-06	3	48	2	19109239
Pubmed	Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma.	CLDN7 CLDN1	5.59e-06	3	48	2	21480761
Pubmed	Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy.	CLDN7 CLDN1	5.59e-06	3	48	2	20651236
Pubmed	Loss of tight junction proteins (Claudin 1, 4, and 7) correlates with aggressive behavior in colorectal carcinoma.	CLDN7 CLDN1	5.59e-06	3	48	2	25038829
Pubmed	Expression patterns of claudins 1, 4, and 7 and their prognostic significance in nasopharyngeal carcinoma.	CLDN7 CLDN1	5.59e-06	3	48	2	25778318
Pubmed	Correlation of Serum Soluble Fibrinogen-Like Protein 2 with Soluble FAS Ligand and Interferon Gamma in Egyptian Hepatitis C Virus-Infected Patients and Hepatocellular Carcinoma Patients.	FASLG FGL2	5.59e-06	3	48	2	28609212
Pubmed	Cycling hypoxia affects cell invasion and proliferation through direct regulation of claudin1 / claudin7 expression, and indirect regulation of P18 through claudin7.	CLDN7 CLDN1	5.59e-06	3	48	2	28055967
Pubmed	T-cells mediate an inhibitory effect of interleukin-4 on osteoclastogenesis.	FASLG IL4R	1.12e-05	4	48	2	12817750
Pubmed	Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum.	CLDN7 CLDN1	1.12e-05	4	48	2	18802961
Pubmed	Expression of claudins-1, -4, -5, -7 and occludin in hepatocellular carcinoma and their relation with classic clinicopathological features and patients' survival.	CLDN7 CLDN1	1.12e-05	4	48	2	24815833
Pubmed	Identification of claudin‑1, ‑3, ‑7 and ‑8 as prognostic markers in human laryngeal carcinoma.	CLDN7 CLDN1	1.12e-05	4	48	2	31115553
Pubmed	HBx activates FasL and mediates HepG2 cell apoptosis through MLK3-MKK7-JNKs signal module.	MAP3K11 FASLG	1.12e-05	4	48	2	22509080
Pubmed	Diverse regulation of claudin-1 and claudin-4 in atopic dermatitis.	CLDN7 CLDN1	1.12e-05	4	48	2	26319240
Pubmed	Distinct claudin expression profile in histologic subtypes of lung cancer.	CLDN7 CLDN1	1.86e-05	5	48	2	17418912
Pubmed	Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines.	CLDN7 CLDN1	1.86e-05	5	48	2	19661441
Pubmed	Expression of occludin and claudins 1, 3, 4, and 7 in urothelial carcinoma of the upper urinary tract.	CLDN7 CLDN1	1.86e-05	5	48	2	18550469
Pubmed	Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung.	CLDN7 CLDN1	1.86e-05	5	48	2	20478039
Pubmed	Variants of chemokine receptor 2 and interleukin 4 receptor, but not interleukin 10 or Fas ligand, increase risk of cervical cancer.	FASLG IL4R	1.86e-05	5	48	2	17688234
Pubmed	H3K36 histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm.	PFN2 CLDN1	2.79e-05	6	48	2	25242323
Pubmed	Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand.	FASLG IL4R	3.90e-05	7	48	2	15096489
Pubmed	IL-4/IL-13 signaling beyond JAK/STAT.	IRS2 IL4R	3.90e-05	7	48	2	10856136
Pubmed	Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.	CLDN7 CLDN1	5.19e-05	8	48	2	9892664
Pubmed	IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin.	IL4R CLDN1	5.19e-05	8	48	2	27357235
Pubmed	Claudins in human cancer: a review.	CLDN7 CLDN1	5.19e-05	8	48	2	19924644
Pubmed	Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury.	CLDN7 CLDN1	5.19e-05	8	48	2	22946046
Pubmed	The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2.	IRS2 IL4R	8.33e-05	10	48	2	27742835
Pubmed	Claudin association with CD81 defines hepatitis C virus entry.	CLDN7 CLDN1	8.33e-05	10	48	2	20375010
Pubmed	claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing.	CLDN7 CLDN1	8.33e-05	10	48	2	11585919
Pubmed	Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy.	CLDN7 CLDN1	8.33e-05	10	48	2	29617460
Pubmed	Permeability barrier dysfunction in transgenic mice overexpressing claudin 6.	CLDN7 CLDN1	8.33e-05	10	48	2	11923212
Pubmed	Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.	MAP3K11 MAP3K21	8.33e-05	10	48	2	28757353
Pubmed	Expression of claudins in murine tooth development.	CLDN7 CLDN1	1.02e-04	11	48	2	17075866
Pubmed	Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.	OR13C9 OR13C8	1.22e-04	12	48	2	12906860
Pubmed	Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.	CLDN7 CLDN1	1.22e-04	12	48	2	10601346
Pubmed	Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland.	CLDN7 CLDN1	1.68e-04	14	48	2	15366020
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	RNF34 FBXO10 FBXL4	2.25e-04	85	48	3	19028597
Pubmed	Immunomodulatory role of Keratin 76 in oral and gastric cancer.	CLDN7 CLDN1	2.50e-04	17	48	2	30143634
Pubmed	Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.	MAP3K11 FASLG	2.81e-04	18	48	2	23982205
Pubmed	HIV tat and neurotoxicity.	GRIN1 CLDN1	3.14e-04	19	48	2	16697675
Pubmed	Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function.	CLDN7 CLDN1	3.14e-04	19	48	2	22155109
Pubmed	Biology of claudins.	CLDN7 CLDN1	3.14e-04	19	48	2	18480174
Pubmed	Multifunctional strands in tight junctions.	CLDN7 CLDN1	3.85e-04	21	48	2	11283726
Pubmed	Claudin-based barrier in simple and stratified cellular sheets.	CLDN7 CLDN1	3.85e-04	21	48	2	12231346
Pubmed	Tight junction proteins.	CLDN7 CLDN1	3.85e-04	21	48	2	12475568
Pubmed	Tight junctions of the blood-brain barrier.	CLDN7 CLDN1	3.85e-04	21	48	2	10690502
Pubmed	The roles of claudin superfamily proteins in paracellular transport.	CLDN7 CLDN1	3.85e-04	21	48	2	11247307
Pubmed	Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.	GALNT10 ACAN	4.23e-04	22	48	2	25107907
Pubmed	Structure and function of claudins.	CLDN7 CLDN1	4.63e-04	23	48	2	18036336
Pubmed	The claudins.	CLDN7 CLDN1	4.63e-04	23	48	2	19706201
Pubmed	Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.	GRIN1 ACAN	5.48e-04	25	48	2	31665922
Pubmed	Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.	CLDN7 CLDN1	5.93e-04	26	48	2	22275141
Pubmed	Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function.	CLDN7 CLDN1	7.39e-04	29	48	2	34267243
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	C19orf44 MAP3K11 IRS2 CLDN7 SLC45A1 IL4R FAM83H	7.57e-04	1105	48	7	35748872
Pubmed	Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas.	CLDN7 CLDN1	8.45e-04	31	48	2	22178591
Pubmed	Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10.	SLAMF9 FASLG	8.45e-04	31	48	2	15921521
Pubmed	Identification of a family of human F-box proteins.	FBXO10 FBXL4	1.20e-03	37	48	2	10531035
Cytoband	9q31.1	OR13C9 OR13C8	8.55e-04	41	48	2	9q31.1
Cytoband	12q24.31	RNF34 MORN3	3.21e-03	80	48	2	12q24.31
GeneFamily	Claudins	CLDN7 CLDN1	1.00e-03	23	37	2	488
GeneFamily	Olfactory receptors, family 13	OR13C9 OR13C8	1.00e-03	23	37	2	162
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K11 MAP3K21	1.09e-03	24	37	2	654
GeneFamily	Solute carriers	SLC35G2 SLC45A1 SLC35C1 SLC23A3 SLC5A3	1.19e-03	395	37	5	752
Disease	atopic dermatitis (is_implicated_in)	IL4R CLDN1	8.21e-04	26	48	2	DOID:3310 (is_implicated_in)
Disease	transforming growth factor beta measurement	CELA1 ADGRL2	8.86e-04	27	48	2	EFO_0004818
Disease	pancreatic ductal carcinoma (is_marker_for)	FASLG IL4R	4.46e-03	61	48	2	DOID:3587 (is_marker_for)
Disease	renal agenesis, unilateral	ACAN CLDN1	4.46e-03	61	48	2	MONDO_0019636

Protein segments in the cluster

Peptide	Gene	Start	Entry
NCSMKFGSWTYDGTM	CHRNB3	166	Q05901
TIYANKGCGVWMMSS	FBXO10	641	Q9UK96
YAQWMAACMLASKGK	FERMT1	461	Q9BQL6
RTMMGYWSTQGCKLV	ADGRL2	796	O95490
QYWGRTEKVMFGMAC	ADCY10	461	Q96PN6
KGQCYWGLSYMGTNM	INPP1	216	P49441
KKYWDNGMTSLGSVC	HDX	451	Q7Z353
KGSGAKACQMIMGSW	LEXM	336	Q3ZCV2
QYEISFKVWMCGGRM	GALNT10	346	Q86SR1
TWTLQLMGLCFMYSG	NEMP1	281	O14524
GMKLPWLYVGMCFSS	KDM5B	481	Q9UGL1
YWGSTVKNTMVCAGG	CELA1	181	Q9UNI1
LYLAWQAGMDMCSAG	ACAN	286	P16112
MAGWQSYVDNLMCDG	PFN2	1	P35080
SPEDSGYMRMWCGSK	IRS2	736	Q9Y4H2
WRGNTQKATCMKMGY	OTULIN	96	Q96BN8
SNMMVLGGSSAYTWV	SLC35C1	326	Q96A29
SDYMSISTCEWKMNG	IL4R	36	P24394
MYEGLWMSCVSQSTG	CLDN1	46	O95832
GSENSMSYTMWNLAG	FBXL4	66	Q9UKA2
TYEWTKVASMAAMGP	C19orf44	541	Q9H6X5
CGYSMNGMKSDGTYW	AMD1	226	P17707
AMGASCVWYVMVTAA	G6PC2	116	Q9NQR9
YCDMETMGGGWTVLQ	FGL2	241	Q14314
GKNDTMMCAVYGWTE	EML5	861	Q05BV3
DCAVVMSGSYSFMWS	FAM83H	236	Q6ZRV2
QKYNSGVTMGCWGMC	SLC45A1	601	Q9Y2W3
SNWCYVLPSMKMGQI	C18orf63	196	Q68DL7
KTTQMSAAGTYAWMA	MAP3K11	276	Q16584
GFWVDNMAKCGTMID	MORN3	186	Q6PF18
MKEYASALMAGGSWL	OR2AJ1	136	Q8NGZ0
MSKGAYVAMAAGSWV	OR13C8	136	Q8NGS7
MSKNAYVPMAVGSWF	OR13C9	136	Q8NGT0
KMSTAGTYAWMAPEV	MAP3K21	301	Q5TCX8
AWKEAFGYTMTVMAG	SLC35G2	251	Q8TBE7
IMFALGMNYWSCSGF	SPP2	16	Q13103
MCIGFFAMWKSNRST	SLC5A3	21	P53794
FFSCGMSTILQTWMG	SLC23A3	91	Q6PIS1
MYKGLWMDCVTQSTG	CLDN7	46	O95471
GGVAMYAVSWCFMFS	TLCD5	196	Q6ZRR5
QMGWYAAKCMAAASS	PYROXD1	381	Q8WU10
MKAGATSMWASCCGL	RNF34	1	Q969K3
CSVEKAGMDMTYSWL	SLAMF9	156	Q96A28
MRGFKYTSWSPMGCD	GTF3C4	161	Q9UKN8
EGKMMSYCTTGQMWA	FASLG	226	P48023
AWGLLNVSMAGMIYT	TMEM209	31	Q96SK2
CAESGMTFFWKSQMI	ZNF630	601	Q2M218
GWCSVMYFTRGFQML	TRPV5	461	Q9NQA5
AMLNMTGSGYVWLVG	GRIN1	236	Q05586