Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of presynaptic active zone

RIMS1 BSN RIMS2 PCLO

4.88e-108344GO:0098882
GeneOntologyMolecularFunctionstructural constituent of synapse

RIMS1 BSN RIMS2 PCLO

7.49e-0742344GO:0098918
GeneOntologyMolecularFunctionstructural molecule activity

MACF1 CLDN22 RIMS1 CLDN24 BSN FN1 RIMS2 CLDN8 PCLO

1.29e-05891349GO:0005198
GeneOntologyBiologicalProcessmaintenance of presynaptic active zone structure

BSN RIMS2 PCLO

6.76e-086323GO:0048790
GeneOntologyBiologicalProcesscell junction assembly

MACF1 LRRN3 CLDN22 CLDN24 BSN FN1 PTPRO CLDN8 PCLO

1.38e-07569329GO:0034329
GeneOntologyBiologicalProcesspresynaptic active zone organization

BSN RIMS2 PCLO

4.04e-0710323GO:1990709
GeneOntologyBiologicalProcesscell junction organization

MACF1 LRRN3 CLDN22 CLDN24 BSN FN1 RIMS2 PTPRO CLDN8 PCLO

1.31e-069743210GO:0034330
GeneOntologyBiologicalProcesspresynapse to nucleus signaling pathway

BSN PCLO

6.99e-063322GO:0099526
GeneOntologyBiologicalProcesspresynaptic signal transduction

BSN PCLO

1.40e-054322GO:0098928
GeneOntologyBiologicalProcesspresynaptic active zone assembly

BSN PCLO

2.33e-055322GO:1904071
GeneOntologyBiologicalProcessmaintenance of synapse structure

BSN RIMS2 PCLO

3.22e-0540323GO:0099558
GeneOntologyBiologicalProcessregulation of calcium-dependent activation of synaptic vesicle fusion

RIMS1 RIMS2

4.87e-057322GO:0150037
GeneOntologyBiologicalProcesspositive regulation of inhibitory postsynaptic potential

RIMS1 RIMS2

1.04e-0410322GO:0097151
GeneOntologyBiologicalProcesscell-cell junction assembly

CLDN22 CLDN24 PTPRO CLDN8

1.25e-04167324GO:0007043
GeneOntologyBiologicalProcessmodulation of excitatory postsynaptic potential

RIMS1 RIMS2 PCLO

1.39e-0465323GO:0098815
GeneOntologyBiologicalProcesscell junction maintenance

BSN RIMS2 PCLO

1.39e-0465323GO:0034331
GeneOntologyBiologicalProcessspontaneous neurotransmitter secretion

RIMS1 RIMS2

1.52e-0412322GO:0061669
GeneOntologyBiologicalProcessmodulation of inhibitory postsynaptic potential

RIMS1 RIMS2

1.52e-0412322GO:0098828
GeneOntologyBiologicalProcesspositive regulation of synaptic vesicle fusion to presynaptic active zone membrane

RIMS1 RIMS2

1.80e-0413322GO:0031632
GeneOntologyBiologicalProcesspositive regulation of synaptic vesicle membrane organization

RIMS1 RIMS2

1.80e-0413322GO:1901634
GeneOntologyBiologicalProcesscalcium-dependent activation of synaptic vesicle fusion

RIMS1 RIMS2

1.80e-0413322GO:0099502
GeneOntologyBiologicalProcessneuron projection morphogenesis

MACF1 RIMS1 FN1 RIMS2 PTPRO MYO16 ZIC2

1.88e-04802327GO:0048812
GeneOntologyBiologicalProcessregulation of membrane potential

KMT2A RIMS1 RIMS2 PCLO SLC4A11 SCN7A

1.92e-04559326GO:0042391
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

MACF1 RIMS1 FN1 RIMS2 PTPRO MYO16 ZIC2

2.14e-04819327GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

MACF1 RIMS1 FN1 RIMS2 PTPRO MYO16 ZIC2

2.25e-04826327GO:0048858
GeneOntologyBiologicalProcessbicellular tight junction assembly

CLDN22 CLDN24 CLDN8

2.67e-0481323GO:0070830
GeneOntologyBiologicalProcessneuron projection extension

MACF1 RIMS1 FN1 RIMS2

2.84e-04207324GO:1990138
GeneOntologyBiologicalProcesssynaptic vesicle docking

RIMS1 RIMS2

3.13e-0417322GO:0016081
GeneOntologyBiologicalProcesspositive regulation of cell growth

MACF1 RIMS1 FN1 RIMS2

3.17e-04213324GO:0030307
GeneOntologyBiologicalProcesstight junction assembly

CLDN22 CLDN24 CLDN8

3.40e-0488323GO:0120192
GeneOntologyBiologicalProcessspontaneous synaptic transmission

RIMS1 RIMS2

3.51e-0418322GO:0098814
GeneOntologyBiologicalProcessapical junction assembly

CLDN22 CLDN24 CLDN8

3.64e-0490323GO:0043297
GeneOntologyBiologicalProcesstight junction organization

CLDN22 CLDN24 CLDN8

4.13e-0494323GO:0120193
GeneOntologyBiologicalProcessregulation of synaptic vesicle fusion to presynaptic active zone membrane

RIMS1 RIMS2

4.35e-0420322GO:0031630
GeneOntologyBiologicalProcesspositive regulation of vesicle fusion

RIMS1 RIMS2

4.35e-0420322GO:0031340
GeneOntologyBiologicalProcessregulation of synaptic vesicle membrane organization

RIMS1 RIMS2

4.35e-0420322GO:1901632
GeneOntologyBiologicalProcessregulation of cellular component size

LRRC8A MACF1 FN1 SWAP70 PCLO

4.67e-04426325GO:0032535
GeneOntologyBiologicalProcesspositive regulation of developmental growth

MACF1 RIMS1 FN1 RIMS2

4.82e-04238324GO:0048639
GeneOntologyBiologicalProcesscellular component maintenance

BSN RIMS2 PCLO

5.10e-04101323GO:0043954
GeneOntologyBiologicalProcesssynaptic vesicle clustering

BSN PCLO

5.28e-0422322GO:0097091
GeneOntologyBiologicalProcesscell-cell junction organization

CLDN22 CLDN24 PTPRO CLDN8

5.46e-04246324GO:0045216
GeneOntologyBiologicalProcessexocytic process

RIMS1 RIMS2 PCLO

6.03e-04107323GO:0140029
GeneOntologyBiologicalProcessretinal ganglion cell axon guidance

PTPRO ZIC2

6.30e-0424322GO:0031290
GeneOntologyBiologicalProcesscalcium ion-regulated exocytosis of neurotransmitter

RIMS1 RIMS2

6.84e-0425322GO:0048791
GeneOntologyBiologicalProcessresponse to osmotic stress

LRRC8A SLC4A11 SCN7A

7.07e-04113323GO:0006970
GeneOntologyBiologicalProcesssynaptic vesicle cycle

RIMS1 BSN RIMS2 PCLO

7.11e-04264324GO:0099504
GeneOntologyBiologicalProcesscalcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules

CLDN22 CLDN8

7.40e-0426322GO:0016338
GeneOntologyBiologicalProcessinhibitory postsynaptic potential

RIMS1 RIMS2

7.99e-0427322GO:0060080
GeneOntologyBiologicalProcesssynaptic vesicle exocytosis

RIMS1 RIMS2 PCLO

9.48e-04125323GO:0016079
GeneOntologyBiologicalProcesspositive regulation of dendrite extension

RIMS1 RIMS2

1.05e-0331322GO:1903861
GeneOntologyBiologicalProcesssynaptic vesicle fusion to presynaptic active zone membrane

RIMS1 RIMS2

1.05e-0331322GO:0031629
GeneOntologyBiologicalProcesssynaptic vesicle priming

RIMS1 RIMS2

1.05e-0331322GO:0016082
GeneOntologyBiologicalProcessexcitatory postsynaptic potential

RIMS1 RIMS2 PCLO

1.06e-03130323GO:0060079
GeneOntologyBiologicalProcessvesicle fusion to plasma membrane

RIMS1 RIMS2

1.12e-0332322GO:0099500
GeneOntologyBiologicalProcessdevelopmental growth involved in morphogenesis

MACF1 RIMS1 FN1 RIMS2

1.13e-03299324GO:0060560
GeneOntologyBiologicalProcessdevelopmental cell growth

MACF1 RIMS1 FN1 RIMS2

1.16e-03301324GO:0048588
GeneOntologyBiologicalProcessregulation of cell morphogenesis

MACF1 RIMS1 FN1 RIMS2

1.17e-03302324GO:0022604
GeneOntologyBiologicalProcessregulation of dendrite extension

RIMS1 RIMS2

1.34e-0335322GO:1903859
GeneOntologyBiologicalProcessregulation of vesicle fusion

RIMS1 RIMS2

1.34e-0335322GO:0031338
GeneOntologyBiologicalProcesssynaptic vesicle membrane organization

RIMS1 RIMS2

1.42e-0336322GO:0048499
GeneOntologyBiologicalProcessvesicle-mediated transport in synapse

RIMS1 BSN RIMS2 PCLO

1.47e-03321324GO:0099003
GeneOntologyBiologicalProcesschemical synaptic transmission, postsynaptic

RIMS1 RIMS2 PCLO

1.51e-03147323GO:0099565
GeneOntologyBiologicalProcesspositive regulation of growth

MACF1 RIMS1 FN1 RIMS2

1.79e-03339324GO:0045927
GeneOntologyBiologicalProcesscell morphogenesis

MACF1 RIMS1 FN1 RIMS2 PTPRO MYO16 ZIC2

2.01e-031194327GO:0000902
GeneOntologyBiologicalProcesspositive regulation of excitatory postsynaptic potential

RIMS1 RIMS2

2.02e-0343322GO:2000463
GeneOntologyBiologicalProcessvesicle docking involved in exocytosis

RIMS1 RIMS2

2.12e-0344322GO:0006904
GeneOntologyBiologicalProcessdendrite extension

RIMS1 RIMS2

2.31e-0346322GO:0097484
GeneOntologyBiologicalProcessregulation of anatomical structure size

LRRC8A MACF1 FN1 SWAP70 PCLO

2.45e-03618325GO:0090066
GeneOntologyBiologicalProcessregulation of nervous system process

RIMS1 RIMS2 PCLO

2.49e-03175323GO:0031644
GeneOntologyBiologicalProcessregulation of postsynaptic membrane potential

RIMS1 RIMS2 PCLO

2.69e-03180323GO:0060078
GeneOntologyBiologicalProcessneuron projection development

MACF1 RIMS1 FN1 RIMS2 PTPRO MYO16 ZIC2

3.04e-031285327GO:0031175
GeneOntologyBiologicalProcesspositive regulation of axon extension

MACF1 FN1

3.29e-0355322GO:0045773
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

KMT2A RIMS1 BSN RIMS2 PCLO

3.31e-03663325GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

KMT2A RIMS1 BSN RIMS2 PCLO

3.34e-03664325GO:0099177
GeneOntologyBiologicalProcesssignal release from synapse

RIMS1 RIMS2 PCLO

3.37e-03195323GO:0099643
GeneOntologyBiologicalProcessneurotransmitter secretion

RIMS1 RIMS2 PCLO

3.37e-03195323GO:0007269
GeneOntologyBiologicalProcesspositive regulation of nervous system process

RIMS1 RIMS2

3.53e-0357322GO:0031646
GeneOntologyBiologicalProcesscell-substrate adhesion

MACF1 FN1 PTPRO FREM1

3.56e-03410324GO:0031589
GeneOntologyBiologicalProcesssynapse organization

LRRN3 BSN RIMS2 PTPRO PCLO

3.81e-03685325GO:0050808
GeneOntologyBiologicalProcesspresynapse assembly

BSN PCLO

3.90e-0360322GO:0099054
GeneOntologyBiologicalProcessregulation of developmental growth

MACF1 RIMS1 FN1 RIMS2

3.91e-03421324GO:0048638
GeneOntologyBiologicalProcessregulation of synaptic vesicle exocytosis

RIMS1 RIMS2

4.16e-0362322GO:2000300
GeneOntologyBiologicalProcessmembrane fusion

IZUMO1 RIMS1 RIMS2

4.21e-03211323GO:0061025
GeneOntologyBiologicalProcessvesicle docking

RIMS1 RIMS2

4.56e-0365322GO:0048278
GeneOntologyBiologicalProcessregulation of cell size

LRRC8A MACF1 FN1

5.03e-03225323GO:0008361
GeneOntologyCellularComponentcytoskeleton of presynaptic active zone

RIMS1 BSN RIMS2 PCLO

3.59e-108334GO:0048788
GeneOntologyCellularComponentpresynaptic cytoskeleton

RIMS1 BSN RIMS2 PCLO

5.09e-0914334GO:0099569
GeneOntologyCellularComponentpresynaptic active zone cytoplasmic component

RIMS1 BSN RIMS2 PCLO

4.46e-0823334GO:0098831
GeneOntologyCellularComponentinhibitory synapse

RIMS1 BSN RIMS2 PCLO

1.57e-0731334GO:0060077
GeneOntologyCellularComponentcell cortex region

RIMS1 BSN RIMS2 PCLO

7.32e-0745334GO:0099738
GeneOntologyCellularComponentGABA-ergic synapse

RIMS1 BSN RIMS2 PTPRO PCLO

5.56e-06164335GO:0098982
GeneOntologyCellularComponentribbon synapse

BSN RIMS2 PCLO

1.72e-0532333GO:0097470
GeneOntologyCellularComponentcortical cytoskeleton

RIMS1 BSN RIMS2 PCLO

4.93e-05129334GO:0030863
GeneOntologyCellularComponentpresynaptic active zone

RIMS1 BSN RIMS2 PCLO

6.97e-05141334GO:0048786
GeneOntologyCellularComponentcell cortex

MACF1 RIMS1 BSN RIMS2 PCLO

2.70e-04371335GO:0005938
GeneOntologyCellularComponentexcitatory synapse

BSN PCLO GNB5

6.36e-04107333GO:0060076
GeneOntologyCellularComponentpostsynaptic density

MACF1 RIMS1 BSN PTPRO PCLO

6.59e-04451335GO:0014069
GeneOntologyCellularComponentasymmetric synapse

MACF1 RIMS1 BSN PTPRO PCLO

8.48e-04477335GO:0032279
GeneOntologyCellularComponentpostsynapse

MACF1 RIMS1 BSN SWAP70 PTPRO PCLO GNB5

8.93e-041018337GO:0098794
GeneOntologyCellularComponentpostsynaptic specialization

MACF1 RIMS1 BSN PTPRO PCLO

1.08e-03503335GO:0099572
GeneOntologyCellularComponentbicellular tight junction

CLDN22 CLDN24 CLDN8

1.14e-03131333GO:0005923
GeneOntologyCellularComponentneuron to neuron synapse

MACF1 RIMS1 BSN PTPRO PCLO

1.28e-03523335GO:0098984
GeneOntologyCellularComponenttight junction

CLDN22 CLDN24 CLDN8

1.36e-03139333GO:0070160
GeneOntologyCellularComponentapical junction complex

CLDN22 CLDN24 CLDN8

1.96e-03158333GO:0043296
GeneOntologyCellularComponentsynaptic membrane

RIMS1 BSN RIMS2 PTPRO GNB5

2.06e-03583335GO:0097060
GeneOntologyCellularComponentparallel fiber to Purkinje cell synapse

PCLO GNB5

2.10e-0343332GO:0098688
GeneOntologyCellularComponentcytoplasmic region

RIMS1 BSN RIMS2 PCLO

2.39e-03360334GO:0099568
GeneOntologyCellularComponentextrinsic component of membrane

RIMS1 BSN GNB5

5.62e-03230333GO:0019898
GeneOntologyCellularComponentapical plasma membrane

CLDN24 FN1 PTPRO SLC4A11

6.97e-03487334GO:0016324
GeneOntologyCellularComponentglutamatergic synapse

RIMS1 BSN RIMS2 PTPRO PCLO

8.62e-03817335GO:0098978
GeneOntologyCellularComponentpresynaptic membrane

RIMS1 RIMS2 GNB5

9.36e-03277333GO:0042734
DomainZnf_FYVE_PHD

KMT2A RIMS1 BSN RIMS2 PCLO GNB5

1.99e-07147336IPR011011
DomainZnf_piccolo

BSN PCLO

3.03e-062332IPR008899
Domainzf-piccolo

BSN PCLO

3.03e-062332PF05715
DomainClaudin_CS

CLDN22 CLDN24 CLDN8

7.56e-0622333IPR017974
DomainCLAUDIN

CLDN22 CLDN24 CLDN8

7.56e-0622333PS01346
DomainClaudin

CLDN22 CLDN24 CLDN8

1.60e-0528333IPR006187
DomainIQ_motif_EF-hand-BS

IQCF3 MYO16 IQCF6 SCN7A

1.85e-0590334IPR000048
DomainPMP22_Claudin

CLDN22 CLDN24 CLDN8

4.75e-0540333PF00822
DomainPMP22/EMP/MP20/Claudin

CLDN22 CLDN24 CLDN8

6.78e-0545333IPR004031
Domain-

KMT2A RIMS1 BSN RIMS2 RNF24 PCLO

1.19e-044493363.30.40.10
DomainZnf_RING/FYVE/PHD

KMT2A RIMS1 BSN RIMS2 RNF24 PCLO

1.34e-04459336IPR013083
DomainFYVE_2

RIMS1 RIMS2

1.65e-0411332PF02318
DomainRABBD

RIMS1 RIMS2

1.98e-0412332PS50916
DomainRab_BD

RIMS1 RIMS2

1.98e-0412332IPR010911
DomainIQ

IQCF3 MYO16 SCN7A

3.90e-0481333SM00015
DomainIQ

IQCF3 MYO16 IQCF6

5.85e-0493333PS50096
DomainC2

RIMS1 RIMS2 PCLO

1.58e-03131333PF00168
DomainZnf_FYVE-rel

RIMS1 RIMS2

1.64e-0334332IPR017455
DomainC2

RIMS1 RIMS2 PCLO

1.79e-03137333SM00239
DomainC2

RIMS1 RIMS2 PCLO

1.99e-03142333PS50004
DomainZnf_FYVE

RIMS1 RIMS2

2.05e-0338332IPR000306
Domain-

RIMS1 RIMS2 PCLO

2.23e-031483332.60.40.150
DomainZF_FYVE

RIMS1 RIMS2

2.26e-0340332PS50178
DomainPDZ

RIMS1 RIMS2 PCLO

2.37e-03151333PS50106
DomainPDZ

RIMS1 RIMS2 PCLO

2.41e-03152333IPR001478
Domainfn3

LRRN3 FN1 PTPRO

2.89e-03162333PF00041
DomainC2_dom

RIMS1 RIMS2 PCLO

2.99e-03164333IPR000008
DomainFN3

LRRN3 FN1 PTPRO

4.19e-03185333SM00060
DomainFN3

LRRN3 FN1 PTPRO

5.14e-03199333PS50853
DomainFN3_dom

LRRN3 FN1 PTPRO

5.89e-03209333IPR003961
DomainIQ

IQCF3 IQCF6

6.97e-0371332PF00612
DomainEF-hand-dom_pair

MACF1 SWAP70 SCN7A

1.39e-02287333IPR011992
PathwayKEGG_MEDICUS_REFERENCE_TIGHT_JUNCTION_ACTIN_SIGNALING_PATHWAY

CLDN22 CLDN24 CLDN8

2.84e-0537233M47769
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

CLDN22 CLDN24 FN1 CLDN8

1.23e-04161234M39770
Pubmed

Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.

RIMS1 BSN PCLO

1.70e-08634314734538
Pubmed

A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1.

RIMS1 BSN PCLO

1.70e-08634319812333
Pubmed

The synaptic vesicle cycle.

RIMS1 BSN RIMS2 PCLO

2.35e-083134415217342
Pubmed

Superresolution imaging of chemical synapses in the brain.

RIMS1 BSN PCLO

7.14e-08934321144999
Pubmed

CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.

CLDN22 CLDN24 CLDN8

1.87e-071234312736707
Pubmed

Biology of claudins.

CLDN22 CLDN24 CLDN8

8.18e-071934318480174
Pubmed

Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation.

BSN PCLO

9.28e-07234223403927
Pubmed

RIM genes differentially contribute to organizing presynaptic release sites.

RIMS1 RIMS2

9.28e-07234222753485
Pubmed

A presynaptic phosphosignaling hub for lasting homeostatic plasticity.

RIMS1 RIMS2

9.28e-07234235443170
Pubmed

Role of Bassoon and Piccolo in Assembly and Molecular Organization of the Active Zone.

BSN PCLO

9.28e-07234226793095
Pubmed

Analysis of RIM Expression and Function at Mouse Photoreceptor Ribbon Synapses.

RIMS1 RIMS2

9.28e-07234228701482
Pubmed

RIM2α is a molecular scaffold for Zona pellucida-induced acrosome reaction.

RIMS1 RIMS2

9.28e-07234225240052
Pubmed

Dual-color STED microscopy reveals a sandwich structure of Bassoon and Piccolo in active zones of adult and aged mice.

BSN PCLO

9.28e-07234227321892
Pubmed

Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis.

BSN PCLO

9.28e-07234220332206
Pubmed

No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington's disease.

BSN PCLO

9.28e-07234232493491
Pubmed

RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes.

RIMS1 RIMS2

9.28e-07234229606581
Pubmed

Active zone density is conserved during synaptic growth but impaired in aged mice.

BSN PCLO

9.28e-07234221935939
Pubmed

RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors.

RIMS1 RIMS2

9.28e-07234226400943
Pubmed

The presynaptic active zone protein RIM1α controls epileptogenesis following status epilepticus.

RIMS1 RIMS2

9.28e-07234222956829
Pubmed

Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.

BSN PCLO

9.28e-07234225652077
Pubmed

Tight junction proteins.

CLDN22 CLDN24 CLDN8

1.12e-062134312475568
Pubmed

Multifunctional strands in tight junctions.

CLDN22 CLDN24 CLDN8

1.12e-062134311283726
Pubmed

Claudin-based barrier in simple and stratified cellular sheets.

CLDN22 CLDN24 CLDN8

1.12e-062134312231346
Pubmed

Tight junctions of the blood-brain barrier.

CLDN22 CLDN24 CLDN8

1.12e-062134310690502
Pubmed

The roles of claudin superfamily proteins in paracellular transport.

CLDN22 CLDN24 CLDN8

1.12e-062134311247307
Pubmed

Structure and function of claudins.

CLDN22 CLDN24 CLDN8

1.49e-062334318036336
Pubmed

The claudins.

CLDN22 CLDN24 CLDN8

1.49e-062334319706201
Pubmed

Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.

CLDN22 CLDN24 CLDN8

2.19e-062634322275141
Pubmed

RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse.

RIMS1 RIMS2

2.78e-06334225343783
Pubmed

C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 α1 subunits are differentially regulated by Rab3-interacting molecule proteins.

RIMS1 RIMS2

2.78e-06334228377503
Pubmed

RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction.

RIMS1 RIMS2

2.78e-06334221241895
Pubmed

Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex.

RIMS1 RIMS2

2.78e-06334225155955
Pubmed

RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain.

RIMS1 RIMS2

2.78e-06334231486769
Pubmed

RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone.

RIMS1 RIMS2

2.78e-06334221262468
Pubmed

Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.

RIMS1 RIMS2

2.78e-06334225730884
Pubmed

Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.

RIMS1 RIMS2

2.78e-06334226034270
Pubmed

Alternative splicing in the first alpha-helical region of the Rab-binding domain of Rim regulates Rab3A binding activity: is Rim a Rab3 effector protein during evolution?

RIMS1 RIMS2

2.78e-06334215330860
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

MACF1 RIMS1 BSN RIMS2 PCLO

2.94e-0623134516452087
Pubmed

Protein composition of axonal dopamine release sites in the striatum.

RIMS1 RIMS2

5.56e-06434236579890
Pubmed

Divergent properties and independent regulation of striatal dopamine and GABA co-transmission.

RIMS1 RIMS2

5.56e-06434235584679
Pubmed

Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels.

RIMS1 RIMS2

5.56e-06434220452978
Pubmed

RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13.

RIMS1 RIMS2

5.56e-06434221262469
Pubmed

Tight junction-based epithelial microenvironment and cell proliferation.

CLDN22 CLDN24

5.56e-06434219029935
Pubmed

Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins.

RIMS1 RIMS2

5.56e-06434212620390
Pubmed

Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.

RIMS1 RIMS2

5.56e-06434227537483
Pubmed

RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.

RIMS1 RIMS2

9.26e-06534222248876
Pubmed

Biallelic variants in TSPOAP1, encoding the active-zone protein RIMBP1, cause autosomal recessive dystonia.

RIMS1 RIMS2

9.26e-06534233539324
Pubmed

Thalamocortical control of cell-type specificity drives circuits for processing whisker-related information in mouse barrel cortex.

RIMS1 RIMS2

9.26e-06534237770450
Pubmed

Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex.

RIMS1 RIMS2

9.26e-06534222553025
Pubmed

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.

RIMS1 RIMS2

9.26e-06534234706221
Pubmed

Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.

RIMS1 RIMS2

9.26e-06534233139401
Pubmed

Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.

RIMS1 RIMS2

9.26e-06534212871946
Pubmed

RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.

RIMS1 RIMS2

9.26e-06534228607399
Pubmed

Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis.

RIMS2 PCLO

9.26e-06534212401793
Pubmed

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.

RIMS1 RIMS2

9.26e-06534232755572
Pubmed

Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland.

CLDN22 CLDN24 CLDN8

1.03e-054334334737342
Pubmed

Piccolo, a presynaptic zinc finger protein structurally related to bassoon.

RIMS2 PCLO

1.39e-05634210707984
Pubmed

The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators.

RIMS1 RIMS2

1.39e-05634231679900
Pubmed

How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.

RIMS1 RIMS2

1.39e-05634227537484
Pubmed

cAMP-GEFII is a direct target of cAMP in regulated exocytosis.

RIMS1 RIMS2

1.39e-05634211056535
Pubmed

Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.

RIMS1 RIMS2

1.94e-05734229398114
Pubmed

Rebuilding essential active zone functions within a synapse.

RIMS1 RIMS2

1.94e-05734235176221
Pubmed

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.

RIMS1 RIMS2

1.94e-05734236398873
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

MACF1 RIMS1 BSN RIMS2 PCLO

2.11e-0534734517114649
Pubmed

Molecular and functional architecture of striatal dopamine release sites.

RIMS1 RIMS2

5.07e-051134234767769
Pubmed

Multiple roles of integrin-α3 at the neuromuscular junction.

BSN PCLO

6.08e-051234228386022
Pubmed

A shared vesicular carrier allows synaptic corelease of GABA and glycine.

RIMS1 RIMS2

6.08e-051234216701208
Pubmed

O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.

BSN PCLO

8.38e-051434216452088
Pubmed

Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.

BSN PCLO

8.38e-051434221228161
Pubmed

Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome.

FN1 FREM1

9.66e-051534223064016
Pubmed

SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.

RIMS1 RIMS2

9.66e-051534223999003
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

MACF1 RIMS2 ZBED1

1.33e-041013439872452
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

MACF1 RIMS1 RIMS2 PCLO

1.60e-0428134428706196
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

MACF1 RIMS1 RIMS2

2.68e-0412834330995482
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

MACF1 SWAP70 MYO16

2.81e-0413034312421765
Pubmed

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.

RIMS1 RIMS2

2.97e-042634217124501
Pubmed

Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.

FN1 FREM1

3.70e-042934222613833
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

KMT2A MACF1 RIMS1 BSN FN1 PCLO GNB5

3.98e-04143134737142655
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

KMT2A MACF1 RIMS1 BSN RIMS2 PCLO SLC4A11

4.17e-04144234735575683
Pubmed

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.

MACF1 DENND3 FREM1

4.43e-0415234334299191
Pubmed

Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth.

FN1 FREM1

4.81e-043334226952977
Pubmed

Host PDZ-containing proteins targeted by SARS-CoV-2.

RIMS1 RIMS2

5.41e-043534233864728
InteractionRAPGEF4 interactions

RIMS1 RIMS2 SWAP70 PCLO

1.00e-0650314int:RAPGEF4
InteractionHSP90B2P interactions

LRRC8A KMT2A PTPRO

7.41e-0625313int:HSP90B2P
InteractionERC2 interactions

RIMS1 BSN PCLO

3.63e-0542313int:ERC2
Cytoband3p21.2

IQCF3 IQCF6

9.03e-05193423p21.2
Cytoband4q35.1

CLDN22 CLDN24

3.30e-04363424q35.1
CytobandEnsembl 112 genes in cytogenetic band chr3p21

BSN IQCF3 IQCF6

1.65e-03316343chr3p21
CytobandEnsembl 112 genes in cytogenetic band chr4q35

CLDN22 CLDN24

3.43e-03117342chr4q35
CytobandEnsembl 112 genes in cytogenetic band chr20p13

RNF24 SLC4A11

3.78e-03123342chr20p13
CytobandEnsembl 112 genes in cytogenetic band chr11q23

KMT2A TTC12

1.16e-02220342chr11q23
GeneFamilyClaudins

CLDN22 CLDN24 CLDN8

4.59e-0623263488
GeneFamilyRegulating synaptic membrane exocytosis family|PDZ domain containing

RIMS1 RIMS2

1.19e-054262833
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

BSN PCLO

2.06e-041526226
GeneFamilyPDZ domain containing

RIMS1 RIMS2 PCLO

1.31e-031522631220
GeneFamilyFibronectin type III domain containing

LRRN3 FN1 PTPRO

1.52e-03160263555
CoexpressionAtlasFacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_500_k-means-cluster#4

MACF1 RIMS2 SOBP PCLO

1.39e-0598324Facebase_RNAseq_e10.5_Olfactory Pit_500_K4
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RIMS1 BSN RIMS2 PCLO

6.41e-061593447747cef94c55144fddcd024a7495318357f1351b
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

IZUMO1 MACF1 FN1 FREM1

8.35e-061703447fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCellP03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MACF1 FN1 FREM1 SCN7A

9.36e-06175344282f09bbdfa70d93b3f66591dcfb84c5ee0268c7
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MACF1 FN1 FAM151A FREM1

9.58e-06176344cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

LRRN3 FN1 FREM1 SCN7A

1.07e-051813449ede19228ba5c0668a9c06c915510b95585216ef
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

RIMS1 BSN RIMS2 PCLO

1.09e-0518234457bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIMS1 BSN PCLO ZIC2

1.19e-05186344d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RIMS1 BSN RIMS2 PCLO

1.19e-05186344b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIMS1 BSN PCLO ZIC2

1.22e-051873441b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RIMS1 BSN RIMS2 PCLO

1.24e-05188344c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

MACF1 LRRN3 FN1 SCN7A

1.29e-0519034471e112dfb8c3190fe0286b45a046ea789eb6a8db
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

MACF1 LRRN3 FN1 SCN7A

1.35e-0519234462904f94dfce430456f05066522cbf9bd29f4d7e
ToppCellControl-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

MACF1 LRRN3 FN1 SCN7A

1.38e-051933445896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

MACF1 FN1 FREM1 SCN7A

1.38e-0519334499525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellRV-02._Fibroblast_II|RV / Chamber and Cluster_Paper

FN1 RNF24 SOBP SCN7A

1.40e-0519434411c79a8c56ece42713b04b321982e41e239f07a5
ToppCell368C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MACF1 LRRN3 FN1 SCN7A

1.40e-05194344d9eec28fa7b255c0ec023276dd955f1e276e7159
ToppCell368C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MACF1 LRRN3 FN1 SCN7A

1.40e-05194344e4d7e9709ce42d4610e44d3445927eefbcbb9eff
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 LRRN3 FN1 SCN7A

1.43e-051953444243190ad291d56694e2155954dbaa879c9d3844
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2A MACF1 FAM151A PCLO

1.43e-051953443e519cffa6144a62b06124642a14c9ff39b76554
ToppCellCOVID-19-Heart-Fib_1|Heart / Disease (COVID-19 only), tissue and cell type

FN1 SOBP FREM1 SCN7A

1.43e-05195344f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MACF1 FN1 FREM1 SCN7A

1.43e-051953441cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2A MACF1 FAM151A PCLO

1.43e-051953447796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 LRRN3 FN1 SCN7A

1.43e-05195344df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-midbrain/hindbrain_cells|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

LRRN3 RIMS2 SOBP ZIC2

1.46e-051963440767581b69bc7e6334d580ca02ed1e831b7b55da
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MACF1 LRRN3 FN1 SCN7A

1.46e-051963446730743cf088c419ccc2d28765769fc09d3ba6a7
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 LRRN3 FN1 SCN7A

1.46e-0519634442e9828222a9663525d571633e8a454c30bfa7f8
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MACF1 FN1 FREM1 SCN7A

1.46e-051963441450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MACF1 LRRN3 FN1 SCN7A

1.46e-0519634421dab89f3699037138a9c7a0e4dc98739a9fad9c
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 LRRN3 FN1 SCN7A

1.46e-05196344cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 LRRN3 FN1 SCN7A

1.46e-051963449737a5f006d37b549f281e1863aca558e1e4dc99
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MACF1 BSN MYO16 FREM1

1.49e-05197344fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 LRRN3 FN1 SCN7A

1.49e-0519734494a9603cbd3516fbcce871909693b88f20d41713
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MACF1 FN1 FREM1 SCN7A

1.49e-0519734431a1852911bda38543916585fda34255fd62a134
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MACF1 FN1 FREM1 SCN7A

1.49e-051973440034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 LRRN3 FN1 SCN7A

1.49e-0519734413896ec65ccda0b928c91d41112dc01b480036b7
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MACF1 FN1 FREM1 SCN7A

1.49e-0519734411a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MACF1 FN1 FREM1 SCN7A

1.52e-0519834417dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCellnormal_Lung-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

MACF1 LRRN3 FN1 SCN7A

1.52e-05198344e0e47cf65774191981840b22905b2094b95abe0f
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MACF1 LRRN3 FN1 SCN7A

1.52e-05198344f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCellproximal-mesenchymal-Alveolar_Fibroblast|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 LRRN3 FN1 SCN7A

1.55e-051993447f4840ae6a888380feca722543e5e52783f3e35d
ToppCelldistal-mesenchymal-Alveolar_Fibroblast-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 LRRN3 FREM1 SCN7A

1.55e-05199344fb23ecce41e31e2cc01814e3c0add756f489561f
ToppCellproximal-3-mesenchymal-Alveolar_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 LRRN3 FN1 SCN7A

1.55e-05199344301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MACF1 FN1 MYO16 FREM1

1.55e-0519934430d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MACF1 LRRN3 FN1 SCN7A

1.55e-0519934466a79732caf2f04c09b4d9832377aa01ca477677
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

MACF1 FN1 MYO16 FREM1

1.55e-05199344c2c42ecf20d1924edc2f899c01dfa5fcf3c210b9
ToppCellproximal-mesenchymal-Alveolar_Fibroblast-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 LRRN3 FN1 SCN7A

1.55e-051993449a16e519fb0651a7c4d8e05b931df4fb3b0eb3d1
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MACF1 FN1 MYO16 FREM1

1.55e-05199344a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellwk_15-18-Mesenchymal-Fibroblast-Alveolar_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

MACF1 FN1 FREM1 SCN7A

1.55e-051993446bce8e65859a35cfea1c210f9c9765952d492ed2
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MACF1 FN1 MYO16 FREM1

1.58e-052003449b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellcellseq-Mesenchymal-Fibroblastic|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MACF1 LRRN3 FN1 SCN7A

1.58e-052003448978867bf69c830b1e48cac2ad6b512dbe60f149
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MACF1 FN1 MYO16 FREM1

1.58e-0520034444a68bacdb3d5bf563bd35952176995850933a81
ToppCellControl_saline-Mesenchymal_fibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

MACF1 FN1 MYO16 FREM1

1.58e-0520034464ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts|Control_saline / Treatment groups by lineage, cell group, cell type

MACF1 FN1 MYO16 FREM1

1.58e-05200344a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MACF1 FN1 MYO16 FREM1

1.58e-05200344dc61016c61729f69649cfb21f6264e685ce83dea
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

MACF1 FN1 MYO16 FREM1

1.58e-05200344bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCelldistal-3-mesenchymal-Alveolar_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

MACF1 LRRN3 FN1 SCN7A

1.58e-0520034420112be28f80baffad92641c9cfd7c3718967dbb
ToppCellE18.5-samps-Epithelial-Alveolar_epithelial-Uncommitted_AE_Progenitor|E18.5-samps / Age Group, Lineage, Cell class and subclass

MYO16 SLC4A11 TTC12

1.12e-041233435f002f5180fe47fe57ab888b5f0319df99ab2c59
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

RIMS1 FREM1 SCN7A

1.79e-041443431c001a5a3bbe4ecbce8305f8b260e933033550dd
ToppCellLPS-antiTNF-Endothelial-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC175 CFAP20DC SLC4A11

1.79e-0414434375b16adfbe84f69376e6566d531ba7919d5c5192
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SOBP FREM1 SCN7A

1.82e-04145343590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCellLPS-antiTNF-Endothelial-Epi-like-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC175 CFAP20DC SLC4A11

2.01e-041503439cb3332924bd67c966873343c14445e30d3f384f
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

PTPRO FREM1 SCN7A

2.22e-04155343105d59d8a1bb8cb37eef2c1767d737b2108ac7c5
ToppCellTCGA-Kidney-Solid_Tissue_Normal-Kidney-Kidney_normal_tissue-5|TCGA-Kidney / Sample_Type by Project: Shred V9

PTPRO FAM151A SCN7A

2.35e-0415834334b284a62cc3fb90429ce579fd8cb8a60178091b
ToppCell356C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MACF1 FN1 SCN7A

2.44e-041603430293b244c063a62819690bf22bbc2681f8d15252
ToppCell356C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

MACF1 FN1 SCN7A

2.44e-041603433eaae86fa08f7651021316f8e5811bf48055591e
ToppCellP07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MACF1 FN1 FREM1

2.48e-04161343b19f82dd98a3064581793711bb70373f18abecd9
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIMS1 BSN SOBP

2.48e-0416134369f5e759c0925daa37e0177a9cc3154842906bf6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RIMS1 RIMS2 RNF24

2.53e-04162343373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCellControl-Epithelial-Ionocyte|Control / Disease state, Lineage and Cell class

CCDC175 CFAP20DC PCLO

2.57e-04163343bf09fa39bf3e6b3a776d5e79c30c96df572956a3
ToppCell10x3'2.3-week_14-16-Lymphocytic_B-B_lineage-immature_B_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SWAP70 PTPRO TTC12

2.62e-0416434369b6566fb88c7449b7ab9056b57508cb6a1aa2af
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

CCDC175 LRRN3 BSN

2.62e-04164343362c16ed7fb37bf16601fd5e059d3f3e2ed692b4
ToppCellsevere-Lymphocytic-B_cells_2|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

RP9 SWAP70 GNB5

2.62e-04164343a1031e9f945a15186ee14c12be47aa11c3c6583b
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|E18.5-samps / Age Group, Lineage, Cell class and subclass

MACF1 FN1 FREM1

2.62e-04164343519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

RIMS1 RIMS2 FAM151A

2.62e-04164343be49af6335f2505065cde2cb9800e4a5516811b1
ToppCell3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZBED1 ZNF443 PCLO

2.71e-041663439fd9de82f98b9acdaa59ac98fb9664161514aec0
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_MEMP|bone_marrow / Manually curated celltypes from each tissue

CCDC175 FREM1 PCLO

2.71e-041663439788486582cc2c5f28b9ea015e235732f9fefb1e
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)|368C / Donor, Lineage, Cell class and subclass (all cells)

LRRN3 FREM1 SCN7A

2.81e-041683431bc6a1915d48f547385ed4f44e118bcc8a4a7b6c
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|368C / Donor, Lineage, Cell class and subclass (all cells)

LRRN3 FREM1 SCN7A

2.81e-0416834369f534de0f9a293047bea03cb1b78551087a8df5
ToppCell367C-Fibroblasts-Fibroblast-G-|367C / Donor, Lineage, Cell class and subclass (all cells)

LRRN3 FN1 SCN7A

2.81e-04168343b8c65542a0701ae31f49d332d87a64578e24b4e3
ToppCell367C-Fibroblasts-Fibroblast-G|367C / Donor, Lineage, Cell class and subclass (all cells)

LRRN3 FN1 SCN7A

2.81e-041683438c95093b1ea45826f62893edd3c410fe53b563a4
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MACF1 FN1 FREM1

2.86e-0416934316c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-MEP|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CCDC175 RIMS1 FREM1

2.86e-041693437d39da562373865876fe16f35649b68da30a0a3a
ToppCell5'-Adult-SmallIntestine-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFAP20DC SWAP70 SOBP

2.86e-04169343a34aff9257ae9746226ee7af595c4678a4b0c896
ToppCell10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CCDC175 FREM1 PCLO

2.91e-041703435bb577e2c4bd275fbe4ee23ff8c007b2fcb90e56
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MACF1 FN1 FREM1

2.91e-04170343e20568c8f3f17d94de78229617eb2f7e4c5af2bc
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIMS1 BSN PCLO

2.96e-0417134399176a932569fa1c7e1c01009684f5a65244b96e
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRRN3 FN1 FREM1

3.01e-0417234329c8510f26527d487d0fc3543102d067cdb281a6
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CLDN22 RIMS1 CLDN24

3.06e-04173343d1e47c87bd4750801f3531f66a56c5dccb4ea64c
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BSN FAM151A PCLO

3.11e-04174343f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CCDC175 FREM1 PCLO

3.11e-0417434366df78280f657978c4a568010ae7d7943869af90
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|356C / Donor, Lineage, Cell class and subclass (all cells)

CLDN22 RIMS1 SLC4A11

3.17e-041753434bfae78ac3a2cb9404382aae96d291504a9cfa14
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|356C / Donor, Lineage, Cell class and subclass (all cells)

CLDN22 RIMS1 SLC4A11

3.17e-04175343af9c5104c86231cfdb93a0f7d7032379efaa009e
ToppCellP03-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MACF1 FN1 DENND3

3.22e-04176343f3a54038cde58326f1caed96ecca33c141bcc8b3
ToppCell3'_v3-blood-Hematopoietic_progenitors|blood / Manually curated celltypes from each tissue

CCDC175 FREM1 PCLO

3.27e-0417734322c77077951889e63489abfabf90900655655c82
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CLDN8 MYO16 SCN7A

3.27e-04177343c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BSN FAM151A PCLO

3.33e-04178343fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MACF1 RIMS1 SLC4A11

3.38e-041793436e965e424eebef50f0202cff75f458be395cfca1
ToppCellwk_15-18-Epithelial-PNS-KCNIP4+_neuron|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

RIMS1 BSN RIMS2

3.38e-04179343e20bfdfb6d5af8556eb66b81a19fbe4e3e28334a
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MACF1 FN1 FREM1

3.38e-04179343b559f5a72cc9e3e35d05cb539b5c2e006e56e652
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2A MACF1 DENND3

3.44e-04180343423454e3390080ae03bb3cbb267255ebfe4df080
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

MACF1 FN1 SCN7A

1.12e-0449213GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_3
ComputationalGenes in the cancer module 11.

KMT2A BSN RIMS2 PTPRO GNB5 ZIC2

4.44e-04540216MODULE_11
Diseaseschizophrenia (implicated_via_orthology)

LRRN3 RIMS1 RIMS2 ZIC2

1.00e-0668334DOID:5419 (implicated_via_orthology)
Diseasecerebral white matter volume change measurement, age at assessment

KMT2A FREM1

4.50e-0428332EFO_0008007, EFO_0021499
Diseaserosacea severity measurement

RIMS1 PCLO TTC12

5.92e-04147333EFO_0009180
Diseasethioredoxin domain-containing protein 12 measurement

BSN IQCF6

8.76e-0439332EFO_0008298
DiseaseSmall cell carcinoma of lung

KMT2A RIMS2

1.67e-0354332C0149925
DiseaseDisorder of eye

RP9 RIMS1 FREM1

1.70e-03212333C0015397

Protein segments in the cluster

PeptideGeneStartEntry
WQTCVIQEEVGMQCK

CLDN24

51

A6NM45
SEINCMIRVKKQVWV

DENND3

1121

A2RUS2
NKVLCMDWCKDKRRI

GNB5

106

O14775
QVTQDKMICLPCKWV

LRRC8A

46

Q8IWT6
DLVIQWCRMLKCNVK

KIAA0100

1006

Q14667
CRLVLQQCKLQGWQM

MYO16

1111

Q9Y6X6
QVKEWLCLNCQMQRA

BSN

211

Q9UPA5
EVKEWLCLNCQMKRA

PCLO

631

Q9Y6V0
MRKVWCCQILLKRNQ

OR4P4

296

Q8NGL7
CVLVQRQGKWQTKDC

FREM1

2151

Q5H8C1
QATVKLQSCIRMWQC

IQCF3

91

P0C7M6
CQEWAVVKVQAQVRM

IQCF6

41

A8MYZ5
SQLQWMKQLCLCVEQ

MACF1

766

Q9UPN3
CVQLMWMKKKQQFCI

PTPRO

1191

Q16827
KVVMWVCNLCRKQQE

RIMS1

156

Q86UR5
VMWVCNLCRKQQEIL

RIMS2

161

Q9UQ26
WQTCVIQEEVGMQCK

CLDN22

51

Q8N7P3
RCVITQWKMACLRKK

CCDC175

451

P0C221
MVCREQLSKNQVKWV

FAM151A

1

Q8WW52
QWLKTQGNKQMLCTC

FN1

321

P02751
KQCCKMRKCQNLQWM

KMT2A

1186

Q03164
VMLQTLIWCKNCKKE

IZUMO1

141

Q8IYV9
QSWLCIICTMKALQK

SLC4A11

196

Q8NBS3
LGKEVKVMQCWRCKR

RP9

96

Q8TA86
RCDCVIRWMNMNKTN

LRRN3

371

Q9H3W5
IKWLEVRKVCPLCNM

RNF24

106

Q9Y225
MIKRKIWCNLCIDLV

CFAP20DC

1

Q6ZVT6
WMNCVRQANIRMQCK

CLDN8

51

P56748
NVQIMCAWCQKVGIK

SOBP

146

A7XYQ1
CNKNVVGRCKLWMII

TTMP

56

Q5BVD1
TIRNLDCVVMKWKDQ

ZNF443

36

Q9Y2A4
EMVCVSVLKLWQAVC

TTC12

311

Q9H892
QNIRKTCCKIVENNW

SCN7A

921

Q01118
NRMCWTLCVKKNLTK

SWAP70

91

Q9UH65
QWKKIYCRICMAQIA

ZBED1

41

O96006
YMRQQCIKQELICKW

ZIC2

246

O95409