Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F8 CYP4F3 CYP4F12 CYP4F11	7.32e-10	5	71	4	GO:0052871
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F8 CYP4F3 CYP4F12 CYP4F11	5.09e-09	7	71	4	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F8 CYP4F3 CYP4F12 CYP4F11	5.09e-09	7	71	4	GO:0018685
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4F8 CYP4F3 CYP4F12 CYP4F11	3.03e-08	10	71	4	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4F8 CYP4F3 CYP4F12 CYP4F11	3.03e-08	10	71	4	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4F8 CYP4F3 CYP4F12 CYP4F11	3.03e-08	10	71	4	GO:0102033
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4F8 CYP4F3 CYP4F12 CYP4F11	1.02e-07	13	71	4	GO:0016713
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP4F8 CYP4F3 CYP4F12 CYP4F11	1.48e-06	24	71	4	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP4F8 CYP4F3 CYP4F12 CYP4F11	2.42e-06	27	71	4	GO:0008391
GeneOntologyMolecularFunction	aromatase activity	CYP4F8 CYP4F3 CYP4F12 CYP4F11	7.07e-06	35	71	4	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	CYP4F8 CYP4F3 CYP4F12 CYP4F11	1.22e-05	40	71	4	GO:0016709
GeneOntologyMolecularFunction	arachidonate binding	CYP4F8 CYP4F12 CYP4F11	1.90e-05	15	71	3	GO:0050544
GeneOntologyMolecularFunction	icosanoid binding	CYP4F8 CYP4F12 CYP4F11	2.33e-05	16	71	3	GO:0050542
GeneOntologyMolecularFunction	icosatetraenoic acid binding	CYP4F8 CYP4F12 CYP4F11	2.33e-05	16	71	3	GO:0050543
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP4F8 CYP4F3 CYP4F12 CYP4F11	2.76e-05	49	71	4	GO:0016712
GeneOntologyMolecularFunction	long-chain fatty acid binding	CYP4F8 CYP4F12 CYP4F11	1.32e-04	28	71	3	GO:0036041
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activator activity	NOXA1 NCF4	5.51e-04	10	71	2	GO:0016176
GeneOntologyMolecularFunction	monooxygenase activity	CYP4F8 CYP4F3 CYP4F12 CYP4F11	7.54e-04	115	71	4	GO:0004497
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	GCDH ACAD10	8.04e-04	12	71	2	GO:0052890
GeneOntologyMolecularFunction	acyl-CoA dehydrogenase activity	GCDH ACAD10	8.04e-04	12	71	2	GO:0003995
GeneOntologyMolecularFunction	fatty acid binding	CYP4F8 CYP4F12 CYP4F11	1.91e-03	69	71	3	GO:0005504
GeneOntologyMolecularFunction	heme binding	CYP4F8 CYP4F3 CYP4F12 CYP4F11	2.21e-03	154	71	4	GO:0020037
GeneOntologyMolecularFunction	tetrapyrrole binding	CYP4F8 CYP4F3 CYP4F12 CYP4F11	2.78e-03	164	71	4	GO:0046906
GeneOntologyMolecularFunction	iron ion binding	CYP4F8 CYP4F3 CYP4F12 CYP4F11	2.90e-03	166	71	4	GO:0005506
GeneOntologyMolecularFunction	K63-linked polyubiquitin modification-dependent protein binding	PARP10 SPRTN	3.83e-03	26	71	2	GO:0070530
GeneOntologyBiologicalProcess	leukotriene B4 catabolic process	CYP4F8 CYP4F3 CYP4F12 CYP4F11	1.81e-09	6	70	4	GO:0036101
GeneOntologyBiologicalProcess	leukotriene B4 metabolic process	CYP4F8 CYP4F3 CYP4F12 CYP4F11	4.22e-09	7	70	4	GO:0036102
GeneOntologyBiologicalProcess	leukotriene catabolic process	CYP4F8 CYP4F3 CYP4F12 CYP4F11	8.43e-09	8	70	4	GO:0036100
GeneOntologyBiologicalProcess	icosanoid catabolic process	CYP4F8 CYP4F3 CYP4F12 CYP4F11	3.94e-08	11	70	4	GO:1901523
GeneOntologyBiologicalProcess	long-chain fatty acid catabolic process	CYP4F8 CYP4F3 CYP4F12 CYP4F11	5.90e-08	12	70	4	GO:0042758
GeneOntologyBiologicalProcess	fatty acid derivative catabolic process	CYP4F8 CYP4F3 CYP4F12 CYP4F11	8.50e-07	22	70	4	GO:1901569
GeneOntologyBiologicalProcess	fatty acid catabolic process	CYP4F8 GCDH CYP4F3 CYP4F12 ACAD10 CYP4F11	2.72e-06	116	70	6	GO:0009062
GeneOntologyBiologicalProcess	fatty acid derivative metabolic process	CYP4F8 GCDH CYP4F3 CYP4F12 CYP4F11	8.68e-06	82	70	5	GO:1901568
GeneOntologyBiologicalProcess	monocarboxylic acid catabolic process	CYP4F8 GCDH CYP4F3 CYP4F12 ACAD10 CYP4F11	9.85e-06	145	70	6	GO:0072329
GeneOntologyBiologicalProcess	leukotriene metabolic process	CYP4F8 CYP4F3 CYP4F12 CYP4F11	1.12e-05	41	70	4	GO:0006691
GeneOntologyBiologicalProcess	omega-hydroxylase P450 pathway	CYP4F8 CYP4F12 CYP4F11	1.33e-05	14	70	3	GO:0097267
GeneOntologyBiologicalProcess	menaquinone catabolic process	CYP4F12 CYP4F11	3.40e-05	3	70	2	GO:0042361
GeneOntologyBiologicalProcess	menaquinone metabolic process	CYP4F12 CYP4F11	6.78e-05	4	70	2	GO:0009233
GeneOntologyBiologicalProcess	phylloquinone metabolic process	CYP4F12 CYP4F11	6.78e-05	4	70	2	GO:0042374
GeneOntologyBiologicalProcess	phylloquinone catabolic process	CYP4F12 CYP4F11	6.78e-05	4	70	2	GO:0042376
GeneOntologyBiologicalProcess	vitamin K catabolic process	CYP4F12 CYP4F11	6.78e-05	4	70	2	GO:0042377
GeneOntologyBiologicalProcess	arachidonate metabolic process	CYP4F8 CYP4F3 CYP4F12 CYP4F11	8.41e-05	68	70	4	GO:0019369
GeneOntologyBiologicalProcess	organic hydroxy compound catabolic process	CYP4F8 CYP4F3 CYP4F12 CYP4F11	1.11e-04	73	70	4	GO:1901616
GeneOntologyBiologicalProcess	stomach development	ASCL1 EXT1	1.13e-04	5	70	2	GO:0062094
GeneOntologyBiologicalProcess	prostaglandin catabolic process	CYP4F12 CYP4F11	1.69e-04	6	70	2	GO:1905344
GeneOntologyBiologicalProcess	prostanoid catabolic process	CYP4F12 CYP4F11	1.69e-04	6	70	2	GO:0062232
GeneOntologyBiologicalProcess	glandular epithelial cell differentiation	CLCN2 ASCL1 SMO EXT1	2.60e-04	91	70	4	GO:0002067
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	NDST1 EXT1	3.14e-04	8	70	2	GO:0015014
GeneOntologyBiologicalProcess	organic acid catabolic process	CYP4F8 GCDH CYP4F3 CYP4F12 ACAD10 CYP4F11	3.22e-04	272	70	6	GO:0016054
GeneOntologyBiologicalProcess	carboxylic acid catabolic process	CYP4F8 GCDH CYP4F3 CYP4F12 ACAD10 CYP4F11	3.22e-04	272	70	6	GO:0046395
GeneOntologyBiologicalProcess	olefinic compound metabolic process	CYP4F8 CLCN2 CYP4F3 CYP4F12 CYP4F11	3.66e-04	180	70	5	GO:0120254
GeneOntologyBiologicalProcess	vitamin K metabolic process	CYP4F12 CYP4F11	6.12e-04	11	70	2	GO:0042373
GeneOntologyBiologicalProcess	heparin biosynthetic process	NDST1 EXT1	6.12e-04	11	70	2	GO:0030210
GeneOntologyBiologicalProcess	fat-soluble vitamin catabolic process	CYP4F12 CYP4F11	7.33e-04	12	70	2	GO:0042363
GeneOntologyBiologicalProcess	fatty acid beta-oxidation using acyl-CoA dehydrogenase	GCDH ACAD10	7.33e-04	12	70	2	GO:0033539
GeneOntologyBiologicalProcess	long-chain fatty acid metabolic process	CYP4F8 CYP4F3 CYP4F12 CYP4F11	8.40e-04	124	70	4	GO:0001676
GeneOntologyBiologicalProcess	regulation of somatic stem cell population maintenance	LBH SMO	8.64e-04	13	70	2	GO:1904672
GeneOntologyBiologicalProcess	telencephalon development	DMXL2 KIF26A ASCL1 SMO EXT1 DNAH5	9.17e-04	332	70	6	GO:0021537
GeneOntologyBiologicalProcess	unsaturated fatty acid metabolic process	CYP4F8 CYP4F3 CYP4F12 CYP4F11	9.45e-04	128	70	4	GO:0033559
Domain	Cyt_P450_E_grp-I	CYP4F8 CYP4F3 CYP4F12 CYP4F11	2.68e-05	45	72	4	IPR002401
Domain	Cyt_P450_CS	CYP4F8 CYP4F3 CYP4F12 CYP4F11	5.15e-05	53	72	4	IPR017972
Domain	CYTOCHROME_P450	CYP4F8 CYP4F3 CYP4F12 CYP4F11	6.87e-05	57	72	4	PS00086
Domain	-	CYP4F8 CYP4F3 CYP4F12 CYP4F11	7.36e-05	58	72	4	1.10.630.10
Domain	p450	CYP4F8 CYP4F3 CYP4F12 CYP4F11	7.36e-05	58	72	4	PF00067
Domain	Cyt_P450	CYP4F8 CYP4F3 CYP4F12 CYP4F11	8.41e-05	60	72	4	IPR001128
Domain	Aspartic_peptidase_N	PGA4 PGA5	3.04e-04	7	72	2	IPR012848
Domain	A1_Propeptide	PGA4 PGA5	3.04e-04	7	72	2	PF07966
Domain	Aspartic_peptidase_A1	PGA4 PGA5	6.46e-04	10	72	2	IPR001461
Domain	PEPTIDASE_A1	PGA4 PGA5	6.46e-04	10	72	2	IPR033121
Domain	Asp	PGA4 PGA5	6.46e-04	10	72	2	PF00026
Domain	PEPTIDASE_A1	PGA4 PGA5	6.46e-04	10	72	2	PS51767
Domain	ACYL_COA_DH_1	GCDH ACAD10	6.46e-04	10	72	2	PS00072
Domain	ACYL_COA_DH_2	GCDH ACAD10	6.46e-04	10	72	2	PS00073
Domain	Acyl-CoA_dh_N	GCDH ACAD10	7.88e-04	11	72	2	PF02771
Domain	-	PGA4 PGA5	9.43e-04	12	72	2	2.40.70.10
Domain	ASP_PROTEASE	PGA4 PGA5	9.43e-04	12	72	2	PS00141
Domain	AcylCoA_DH/ox_N	GCDH ACAD10	1.11e-03	13	72	2	IPR013786
Domain	-	GCDH ACAD10	1.11e-03	13	72	2	1.10.540.10
Domain	Aspartic_peptidase_AS	PGA4 PGA5	1.11e-03	13	72	2	IPR001969
Domain	Acyl-CoA_dh_1	GCDH ACAD10	1.11e-03	13	72	2	PF00441
Domain	PB1	NOXA1 NCF4	1.29e-03	14	72	2	SM00666
Domain	PB1	NOXA1 NCF4	1.29e-03	14	72	2	PF00564
Domain	PB1	NOXA1 NCF4	1.29e-03	14	72	2	PS51745
Domain	PB1_dom	NOXA1 NCF4	1.29e-03	14	72	2	IPR000270
Domain	Acyl-CoA_Oxase/DH_cen-dom	GCDH ACAD10	1.49e-03	15	72	2	IPR006091
Domain	Acyl-CoA_dh_M	GCDH ACAD10	1.49e-03	15	72	2	PF02770
Domain	AcylCoA_DH/oxidase_NM_dom	GCDH ACAD10	1.49e-03	15	72	2	IPR009100
Domain	GRAM	TBC1D9B SBF1	1.70e-03	16	72	2	SM00568
Domain	AcylCo_DH/oxidase_C	GCDH ACAD10	1.70e-03	16	72	2	IPR009075
Domain	Peptidase_aspartic_dom	PGA4 PGA5	1.92e-03	17	72	2	IPR021109
Domain	Chromodomain_CS	CBX3 CBX2	2.15e-03	18	72	2	IPR023779
Domain	TPR-contain_dom	LONRF1 IFIT1B NOXA1 VPS13A	2.69e-03	150	72	4	IPR013026
Domain	GRAM	TBC1D9B SBF1	3.22e-03	22	72	2	PF02893
Domain	GRAM	TBC1D9B SBF1	3.22e-03	22	72	2	IPR004182
Domain	TPR_REGION	LONRF1 IFIT1B NOXA1 VPS13A	3.79e-03	165	72	4	PS50293
Domain	TPR	LONRF1 IFIT1B NOXA1 VPS13A	3.79e-03	165	72	4	PS50005
Domain	Chromo_domain	CBX3 CBX2	3.83e-03	24	72	2	IPR023780
Domain	Chromo	CBX3 CBX2	4.49e-03	26	72	2	PF00385
Domain	CHROMO_1	CBX3 CBX2	5.19e-03	28	72	2	PS00598
Domain	CHROMO_2	CBX3 CBX2	5.19e-03	28	72	2	PS50013
Domain	Chromodomain-like	CBX3 CBX2	6.75e-03	32	72	2	IPR016197
Domain	Chromo/shadow_dom	CBX3 CBX2	7.16e-03	33	72	2	IPR000953
Domain	CHROMO	CBX3 CBX2	7.16e-03	33	72	2	SM00298
Pathway	REACTOME_EICOSANOIDS	CYP4F8 CYP4F3 CYP4F12 CYP4F11	5.74e-08	12	48	4	M27129
Pathway	REACTOME_EICOSANOIDS	CYP4F8 CYP4F3 CYP4F12 CYP4F11	5.74e-08	12	48	4	MM14845
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES	CYP4F8 CYP4F3 CYP4F12 CYP4F11	1.15e-07	14	48	4	MM15842
Pathway	REACTOME_FATTY_ACIDS	CYP4F8 CYP4F3 CYP4F12 CYP4F11	1.57e-07	15	48	4	M27126
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F8 CYP4F3 CYP4F12 CYP4F11	3.50e-07	18	48	4	MM14843
Pathway	REACTOME_FATTY_ACIDS	CYP4F8 CYP4F3 CYP4F12 CYP4F11	3.50e-07	18	48	4	MM14841
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F8 CYP4F3 CYP4F12 CYP4F11	1.42e-06	25	48	4	MM14858
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX	CYP4F8 CYP4F3 CYP4F12 CYP4F11	4.50e-06	33	48	4	MM15918
Pathway	WP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX	CYP4F8 CYP4F3 CYP4F12 CYP4F11	4.50e-06	33	48	4	MM15963
Pathway	WP_TRYPTOPHAN_METABOLISM	CYP4F8 GCDH CYP4F12 CYP4F11	2.06e-05	48	48	4	MM15902
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	PAOX CYP4F8 CYP4F3 CYP4F12 CYP4F11	2.64e-05	104	48	5	M738
Pathway	REACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS	PAOX CYP4F8 CYP4F3 CYP4F12 CYP4F11	2.77e-05	105	48	5	MM14842
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F8 CYP4F3 CYP4F11	4.72e-05	21	48	3	M27137
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	CYP4F8 CYP4F3 CYP4F12 CYP4F11	5.35e-05	61	48	4	MM14861
Pathway	WP_OXIDATION_BY_CYTOCHROME_P450	CYP4F8 CYP4F3 CYP4F12 CYP4F11	5.71e-05	62	48	4	M39653
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP4F8 CYP4F3 CYP4F12 CYP4F11	6.47e-05	64	48	4	M5650
Pathway	REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE	CYP4F8 CYP4F3 CYP4F12 CYP4F11	7.30e-05	66	48	4	MM14839
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	PAOX CYP4F8 PODXL2 CYP4F3 CYP4F12 CYP4F11	9.34e-05	219	48	6	MM14838
Pathway	REACTOME_BIOLOGICAL_OXIDATIONS	PAOX CYP4F8 PODXL2 CYP4F3 CYP4F12 CYP4F11	9.58e-05	220	48	6	M10320
Pathway	REACTOME_FATTY_ACID_METABOLISM	CYP4F8 CYP4F3 CYP4F12 ACAD10 CYP4F11	2.71e-04	170	48	5	MM15573
Pathway	WP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II	NDST1 CYP4F8 CYP4F3 CYP4F12 CYP4F11	3.80e-04	183	48	5	M39588
Pathway	WP_GASTRIC_ACID_PRODUCTION	PGA4 PGA5	6.12e-04	11	48	2	M39726
Pathway	KEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS	NDST1 EXT1	6.12e-04	11	48	2	M47921
Pathway	REACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE	CYP4F12 CYP4F11	6.12e-04	11	48	2	MM14863
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F3 CYP4F11	7.33e-04	12	48	2	M27128
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	CYP4F8 CYP4F3 CYP4F11	1.05e-03	59	48	3	M27140
Pubmed	The cytochrome P450 4 (CYP4) family.	CYP4F8 CYP4F3 CYP4F12 CYP4F11	2.52e-10	6	72	4	9068972
Pubmed	Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.	CYP4F8 CYP4F12 CYP4F11	3.40e-08	4	72	3	22665481
Pubmed	Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.	CYP4F8 CYP4F12 CYP4F11	3.40e-08	4	72	3	11185557
Pubmed	Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.	CYP4F3 CYP4F12 CYP4F11	3.40e-08	4	72	3	18065749
Pubmed	Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.	CYP4F8 CYP4F12 CYP4F11	8.48e-08	5	72	3	22969154
Pubmed	Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.	CYP4F8 CYP4F12 CYP4F11	8.48e-08	5	72	3	21466787
Pubmed	Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.	CYP4F8 CYP4F12 CYP4F11	2.96e-07	7	72	3	22160543
Pubmed	Crystal structure of human pepsin and its complex with pepstatin.	PGA4 PGA5	4.23e-06	2	72	2	7663352
Pubmed	Expression and physiological function of CYP4F subfamily in human eosinophils.	CYP4F3 CYP4F12	4.23e-06	2	72	2	17980168
Pubmed	Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.	PGA4 PGA5	4.23e-06	2	72	2	2714789
Pubmed	Activation of human pepsinogens.	PGA4 PGA5	4.23e-06	2	72	2	3197840
Pubmed	Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8.	CYP4F8 CYP4F12	4.23e-06	2	72	2	16112640
Pubmed	Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.	PGA4 PGA5	4.23e-06	2	72	2	2415509
Pubmed	Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.	CYP4F3 CYP4F11	4.23e-06	2	72	2	15364545
Pubmed	Close linkage of human chromosomal pepsinogen A genes.	PGA4 PGA5	1.27e-05	3	72	2	3017318
Pubmed	Serum pepsinogen test for early detection of gastric cancer in a European country.	PGA4 PGA5	1.27e-05	3	72	2	21989121
Pubmed	Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.	PGA4 PGA5	1.27e-05	3	72	2	9855083
Pubmed	Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.	PGA4 PGA5	1.27e-05	3	72	2	9797498
Pubmed	The glomerular sieving of pepsinogen A and C in man.	PGA4 PGA5	1.27e-05	3	72	2	2478370
Pubmed	A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation.	NDST1 EXT1	1.27e-05	3	72	2	35137078
Pubmed	Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.	PGA4 PGA5	1.27e-05	3	72	2	3815274
Pubmed	Pepsinogens: physiology, pharmacology pathophysiology and exercise.	PGA4 PGA5	1.27e-05	3	72	2	10675278
Pubmed	Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis.	NDST1 EXT1	1.27e-05	3	72	2	22345168
Pubmed	The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.	PGA4 PGA5	1.27e-05	3	72	2	7926498
Pubmed	Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.	PGA4 PGA5	1.27e-05	3	72	2	3780036
Pubmed	Crystal structure of human pepsinogen A.	PGA4 PGA5	1.27e-05	3	72	2	9561228
Pubmed	The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.	PGA4 PGA5	1.27e-05	3	72	2	21455714
Pubmed	Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.	PGA4 PGA5	1.27e-05	3	72	2	19800305
Pubmed	Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.	PGA4 PGA5	1.27e-05	3	72	2	2901984
Pubmed	Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation.	NDST1 EXT1	1.27e-05	3	72	2	18337501
Pubmed	Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.	PGA4 PGA5	1.27e-05	3	72	2	3839486
Pubmed	Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.	PGA4 PGA5	1.27e-05	3	72	2	24170207
Pubmed	Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.	PGA4 PGA5	1.27e-05	3	72	2	3467902
Pubmed	The pepsinogens of human gastric mucosa.	PGA4 PGA5	1.27e-05	3	72	2	4586732
Pubmed	Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy.	RICTOR DMD	1.27e-05	3	72	2	19046572
Pubmed	Relationships between the human pepsinogen DNA and protein polymorphisms.	PGA4 PGA5	1.27e-05	3	72	2	3014868
Pubmed	Genomic structure and evolution of the human pepsinogen A multigene family.	PGA4 PGA5	1.27e-05	3	72	2	2892778
Pubmed	The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.	PGA4 PGA5	1.27e-05	3	72	2	24383519
Pubmed	Gene structures of pepsinogens A and C.	PGA4 PGA5	1.27e-05	3	72	2	1455184
Pubmed	Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.	PGA4 PGA5	1.27e-05	3	72	2	2831884
Pubmed	The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.	PGA4 PGA5	1.27e-05	3	72	2	2799289
Pubmed	CRYSTALLINE PEPSIN : I. ISOLATION AND TESTS OF PURITY.	PGA4 PGA5	1.27e-05	3	72	2	19872561
Pubmed	Human pepsinogen A (PGA): an informative gene complex located at 11q13.	PGA4 PGA5	1.27e-05	3	72	2	1968039
Pubmed	A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.	PGA4 PGA5	1.27e-05	3	72	2	2515193
Pubmed	Localization of pepsinogen (A and C) and cellular differentiation of pepsinogen-synthesizing cells in the human gastric mucosa.	PGA4 PGA5	1.27e-05	3	72	2	2032552
Pubmed	Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.	PGA4 PGA5	1.27e-05	3	72	2	8053437
Pubmed	Analysis of the promoter of a human pepsinogen A gene.	PGA4 PGA5	1.27e-05	3	72	2	1812762
Pubmed	O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.	PGA4 PGA5	1.27e-05	3	72	2	7923573
Pubmed	Family and population studies on the human pepsinogen A multigene family.	PGA4 PGA5	1.27e-05	3	72	2	2566575
Pubmed	Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping.	PGA4 PGA5	1.27e-05	3	72	2	9061458
Pubmed	Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis.	PGA4 PGA5	1.27e-05	3	72	2	12588289
Pubmed	Immunoblot technique to visualise serum pepsinogen A isozymogen patterns.	PGA4 PGA5	1.27e-05	3	72	2	2229438
Pubmed	Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.	PGA4 PGA5	1.27e-05	3	72	2	25314140
Pubmed	Validation of the pepsinogen test method for gastric cancer screening using a follow-up study.	PGA4 PGA5	1.27e-05	3	72	2	19890696
Pubmed	Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.	PGA4 PGA5	1.27e-05	3	72	2	23897256
Pubmed	An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse.	PGA4 PGA5	1.27e-05	3	72	2	11566730
Pubmed	The effect of acute and chronic protein loading on urinary pepsinogen A excretion.	PGA4 PGA5	1.27e-05	3	72	2	1956484
Pubmed	Transcription regulation of human and porcine pepsinogen A.	PGA4 PGA5	1.27e-05	3	72	2	8540382
Pubmed	Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.	PGA4 PGA5	1.27e-05	3	72	2	8244094
Pubmed	Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.	PGA4 PGA5	1.27e-05	3	72	2	21407214
Pubmed	Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study.	PGA4 PGA5	1.27e-05	3	72	2	22992016
Pubmed	The role of serum pepsinogen in the detection of gastric cancer.	PGA4 PGA5	1.27e-05	3	72	2	20981206
Pubmed	Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A.	PGA4 PGA5	1.27e-05	3	72	2	6774973
Pubmed	Gastric chief cell-specific transcription of the pepsinogen A gene.	PGA4 PGA5	1.27e-05	3	72	2	8504820
Pubmed	Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry.	PGA4 PGA5	1.27e-05	3	72	2	21970995
Pubmed	Primary structure of human pepsinogen gene.	PGA4 PGA5	1.27e-05	3	72	2	6300126
Pubmed	Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.	PGA4 PGA5	1.27e-05	3	72	2	22304859
Pubmed	Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.	PGA4 PGA5	1.27e-05	3	72	2	24004680
Pubmed	Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole.	PGA4 PGA5	1.27e-05	3	72	2	8038355
Pubmed	Serum pepsinogens in gastric cancer screening.	PGA4 PGA5	1.27e-05	3	72	2	20428942
Pubmed	Small changes in lymphocyte development and activation in mice through tissue-specific alteration of heparan sulphate.	NDST1 EXT1	1.27e-05	3	72	2	18479348
Pubmed	Human pepsinogen A isozymogen patterns in serum and gastric mucosa.	PGA4 PGA5	1.27e-05	3	72	2	2227273
Pubmed	The relationship of Helicobacter pylori colonization, the serum pepsinogen A level, and gastric resection.	PGA4 PGA5	1.27e-05	3	72	2	9525001
Pubmed	Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.	PGA4 PGA5	1.27e-05	3	72	2	7886402
Pubmed	Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.	PGA4 PGA5	1.27e-05	3	72	2	23034090
Pubmed	A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.	PGA4 PGA5	1.27e-05	3	72	2	24125879
Pubmed	Serum pepsinogen and gastric cancer screening.	PGA4 PGA5	1.27e-05	3	72	2	17379991
Pubmed	Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C.	PGA4 PGA5	1.27e-05	3	72	2	8751234
Pubmed	Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen A.	PGA4 PGA5	1.27e-05	3	72	2	3554488
Pubmed	Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells.	CBX3 CBX2	1.27e-05	3	72	2	23629965
Pubmed	Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.	PGA4 PGA5	1.27e-05	3	72	2	21547904
Pubmed	Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study.	PGA4 PGA5	1.27e-05	3	72	2	23521833
Pubmed	Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.	CYP4F8 CYP4F3 CYP4F12 CYP4F11	1.40e-05	70	72	4	15128046
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NDST1 TBC1D9B SBF1 KIF26A RRS1 LONRF1 KSR2 ZNF316 FRMD8 CBX2 ATPAF2	1.63e-05	1105	72	11	35748872
Pubmed	Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes.	PGA4 PGA5	2.53e-05	4	72	2	23047493
Pubmed	Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling.	NDST1 EXT1	2.53e-05	4	72	2	21586278
Pubmed	Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability.	NDST1 EXT1	2.53e-05	4	72	2	20974861
Pubmed	Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.	PGA4 PGA5	2.53e-05	4	72	2	11915945
Pubmed	Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.	PGA4 PGA5	2.53e-05	4	72	2	8322031
Pubmed	Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.	PGA4 PGA5	2.53e-05	4	72	2	17136346
Pubmed	Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.	PGA4 PGA5	2.53e-05	4	72	2	12698190
Pubmed	Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts.	RICTOR DMD	2.53e-05	4	72	2	34706731
Pubmed	Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.	NDST1 EXT1	2.53e-05	4	72	2	26024086
Pubmed	Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis.	PGA4 PGA5	4.21e-05	5	72	2	22066020
Pubmed	Multiple roles of epithelial heparan sulfate in stomach morphogenesis.	PGA4 EXT1 PGA5	5.31e-05	35	72	3	29700203
Pubmed	An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.	PGA4 LBH PGA5	6.28e-05	37	72	3	21362171
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MIER2 DMXL2 TBC1D9B DISP3 TSPYL5 RICTOR ZKSCAN5	7.33e-05	493	72	7	15368895
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP4F8 CYP4F12 CYP4F11	1.06e-04	44	72	3	12745259
Pubmed	Recognition and specificity determinants of the human cbx chromodomains.	CBX3 CBX2	1.17e-04	8	72	2	21047797
Pubmed	TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.	CYP4F8 CYP4F12 CYP4F11	1.21e-04	46	72	3	25209997
Cytoband	19p13.1	CYP4F8 CYP4F12 CYP4F11	6.08e-05	48	72	3	19p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	MIER2 CYP4F8 GCDH CYP4F3 CYP4F12 CYP4F11	1.59e-03	797	72	6	chr19p13
GeneFamily	Cytochrome P450 family 4	CYP4F8 CYP4F3 CYP4F12 CYP4F11	2.42e-06	36	48	4	1003
GeneFamily	Chromobox family	CBX3 CBX2	1.91e-04	8	48	2	976
GeneFamily	Acyl-CoA dehydrogenase family	GCDH ACAD10	3.74e-04	11	48	2	974
Drug	Probucol [23288-49-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A	PAOX CYP4F8 SMO NCF4 NKTR PLXNB1 ATPAF2	3.09e-06	198	72	7	3223_UP
Drug	Flucytosine [2022-85-7]; Down 200; 31uM; PC3; HT_HG-U133A	VPS13A PODXL2 ASPSCR1 ACAD10 ZKSCAN5 KRIT1 ATPAF2	3.30e-06	200	72	7	6690_DN
Drug	azo analog I	CYP4F8 CYP4F3 CYP4F12	8.48e-06	13	72	3	CID006438575
Drug	dichloran	CYP4F8 CYP4F3 CYP4F12 CYP4F11	8.52e-06	41	72	4	CID000007430
Drug	lansoprazole	CYP4F8 CYP4F3 CYP4F12 PGA5 CYP4F11	1.15e-05	93	72	5	CID000003883
Drug	bromide	PARP10 CYP4F8 CLCN2 VPS13A PODXL2 CYP4F12 CYP4F11	2.17e-05	267	72	7	CID000000259
Drug	adipic acid	PAOX SLC22A8 GCDH ACAD10	3.43e-05	58	72	4	CID000000196
Drug	AC1Q7AUJ	CYP4F8 GCDH CYP4F3 CYP4F12 CYP4F11	3.50e-05	117	72	5	CID000003303
Disease	Gastrointestinal Stromal Sarcoma	NDST1 SMO DMD	1.62e-04	47	66	3	C3179349
Disease	Gastrointestinal Stromal Tumors	NDST1 SMO DMD	1.94e-04	50	66	3	C0238198
Disease	primary ciliary dyskinesia (implicated_via_orthology)	SPEF2 DNAH5	8.22e-04	19	66	2	DOID:9562 (implicated_via_orthology)
Disease	urinary metabolite measurement	PAOX SLC22A8 RICTOR ZKSCAN5	2.23e-03	245	66	4	EFO_0005116

Protein segments in the cluster

Peptide	Gene	Start	Entry
ERLQAWPAELPDEFF	ASPSCR1	331	Q9BZE9
DPLLQDVWLEEEQEE	DISP3	6	Q9P2K9
WEPEENLDCPELIEA	CBX3	61	Q13185
EGLWNLFLPLEADPE	ACAD10	711	Q6JQN1
EEEIDNTVPPVLNDW	DMXL2	146	Q8TDJ6
WLEEADNIASIPLEP	DMD	2226	P11532
EEFNVDLQEELPSLW	AMPH	181	P49418
VPIPEEESLQRAWQD	NOXA1	366	Q86UR1
LQFAPDREEWEVVFP	ADAMTS19	26	Q8TE59
QWEAPTLVDEQPLEN	PGA5	56	P0DJD9
ILQPPQYFWEEEEEL	PODXL2	91	Q9NZ53
EPETLVELQRNEWDP	ATPAF2	146	Q8N5M1
SPEEEEPILWLEFDG	FRMD8	326	Q9BZ67
WPEEAPDLGQREEDL	FNDC9	161	Q8TBE3
EDLNAVLFQLPDWPE	LONRF1	266	Q17RB8
LQEWDIPFEQLEIGE	KSR2	656	Q6VAB6
GELRWPPEEFLVQED	LBH	76	Q53QV2
KEEWQDEEFPRLLPE	BNIPL	36	Q7Z465
PEDPWVRVEFILDNL	PLXNB1	1346	O43157
ILKDFPEEDDPTNWL	NCF4	226	Q15080
FQIFSEEKDPLWQDP	NDST1	571	P52848
PGRWLEQFEVDPELE	KIF26A	1816	Q9ULI4
DWPEILAELTNLDPQ	KRIT1	486	O00522
EKAEIPILPDVEQFW	GPR151	376	Q8TDV0
WPVVPDDVEQLCNEL	RICTOR	1001	Q6R327
EFPEGLEWLNTEEPI	NHLRC2	56	Q8NBF2
SDPLQQWELVPIEVF	SBF1	1341	O95248
EFLLLDLPIWPEQQA	OR1J4	11	Q8NGS1
QAAPPIELDAVWEDI	PRPF40A	756	O75400
NSWEPEENILDPRLL	CBX2	41	Q14781
ALRPFVPWDQLENED	EXT1	61	Q16394
PEFDWQDPLVLEEQL	GCDH	46	Q92947
PLSPEEQELLDFTNW	ASCL1	221	P50553
NLEFPDTPLEEWQEI	AXDND1	621	Q5T1B0
EPIEIEWDDLAQLPF	CYP4F11	366	Q9HBI6
EPKEIEWDDLAQLPF	CYP4F8	366	P98187
DPKEIEWDDLAQLPF	CYP4F12	366	Q9HCS2
EIPDLENRIWEEIQF	IFIT1B	31	Q5T764
LALWDPNNFEEPVAL	CORO6	246	Q6QEF8
IQSDDDWIPDIQIDP	KNG1	581	P01042
EPKEIEWDDLAQLPF	CYP4F3	366	Q08477
LNQPLPETIEDLENW	SLC22A8	496	Q8TCC7
IWFDKENPEEEPLPN	DNAH5	3971	Q8TE73
ENEDQLLWDPSVLPE	MIER2	221	Q8N344
DWLPRELEEEGPQEQ	PARP10	611	Q53GL7
QWEAPTLVDEQPLEN	PGA4	56	P0DJD7
QEQLERELAPEPWVE	HGH1	371	Q9BTY7
EFEEPFWEPDCQLIQ	PAOX	326	Q6QHF9
LDNWPLLEQWFSEPE	SPEF2	841	Q9C093
WEELEDQLPNFLEEL	SUSD2	296	Q9UGT4
ERWLQPPEESVELQD	TEX14	1411	Q8IWB6
FWDVLDSELNADPPE	TCP11L2	111	Q8N4U5
WQPPLEFGEEEEEEI	NKTR	1016	P30414
EWRSFLDVPAELQPE	PPP1R3G	256	B7ZBB8
WNEPLEFDINICDLP	PIK3CB	381	P42338
DLDLFLPWEAQEALP	TBC1D9B	961	Q66K14
LPWEAQEALPQEEQE	TBC1D9B	966	Q66K14
ILEWEEQQLDEPVNF	CLCN2	771	P51788
WLAIQQLPTDPIEEQ	ZMYND19	126	Q96E35
LEPLEIDQTEDFRPW	VPS13A	1786	Q96RL7
DPPESDRLQILNEAW	VPS35L	476	Q7Z3J2
QFPPEEWPVRDEDDL	STOX1	336	Q6ZVD7
WLIEVPGNADPLEDQ	RRS1	156	Q15050
PEEEIQEGFWDLLIR	SERPINA13P	111	Q6UXR4
VPPEEQANLWLVEAE	SMO	646	Q99835
WELVDPTPDLQALFV	SPRTN	36	Q9H040
LIFRLEQGEEPWVPD	ZNF316	206	A6NFI3
EVILNEPVENWPLCD	PPIP5K2	81	O43314
EQFLTILPEEFQPWV	ZKSCAN5	96	Q9Y2L8
VEIINEELWPNPLQF	TSPYL5	366	Q86VY4
PEWLEAIRTEVPDNQ	UNC79	626	Q9P2D8
EEQWVPDPQDLEERD	ZNF641	166	Q96N77
PWEQAISNDPELLEA	MYOZ2	151	Q9NPC6