Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	growth cone	CBL PREX1 DICER1 NRP1	5.77e-04	245	33	4	GO:0030426
GeneOntologyCellularComponent	site of polarized growth	CBL PREX1 DICER1 NRP1	6.51e-04	253	33	4	GO:0030427
Domain	HR1_rho-bd	PSMC5 FNBP1L	7.81e-04	25	31	2	IPR011072
Domain	-	ZNF521 CBL USP33 MSL2 PDZRN4	7.96e-04	449	31	5	3.30.40.10
Domain	Znf_RING/FYVE/PHD	ZNF521 CBL USP33 MSL2 PDZRN4	8.79e-04	459	31	5	IPR013083
Domain	GDS_CDC24_CS	PREX1 VAV2	1.90e-03	39	31	2	IPR001331
Domain	DH_1	PREX1 VAV2	4.89e-03	63	31	2	PS00741
Domain	RhoGEF	PREX1 VAV2	5.67e-03	68	31	2	SM00325
Domain	DH_2	PREX1 VAV2	6.00e-03	70	31	2	PS50010
Domain	RhoGEF	PREX1 VAV2	6.00e-03	70	31	2	PF00621
Domain	DH-domain	PREX1 VAV2	6.17e-03	71	31	2	IPR000219
Domain	-	PREX1 VAV2	6.17e-03	71	31	2	1.20.900.10
Domain	ZF_RING_1	CBL MSL2 PDZRN4	1.22e-02	291	31	3	PS00518
Domain	ZF_RING_2	CBL MSL2 PDZRN4	1.30e-02	298	31	3	PS50089
Domain	SH2	CBL VAV2	1.45e-02	111	31	2	PS50001
Domain	SH2	CBL VAV2	1.48e-02	112	31	2	IPR000980
Domain	-	CBL VAV2	1.48e-02	112	31	2	3.30.505.10
Pubmed	c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases.	CBL VAV2	8.73e-07	2	33	2	11313921
Pubmed	Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.	CBL VAV2	2.62e-06	3	33	2	20940296
Pubmed	Rho GEFs and cancer: linking gene expression and metastatic dissemination.	PREX1 VAV2	5.23e-06	4	33	2	23033535
Pubmed	Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte.	CBL VAV2	8.72e-06	5	33	2	11262396
Pubmed	Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.	CBL VAV2	1.31e-05	6	33	2	16356860
Pubmed	P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.	PREX1 VAV2	1.31e-05	6	33	2	25538043
Pubmed	P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.	PREX1 VAV2	1.83e-05	7	33	2	21178006
Pubmed	Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors.	CBL VAV2	1.83e-05	7	33	2	8621483
Pubmed	P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.	PREX1 VAV2	2.44e-05	8	33	2	24659802
Pubmed	Mdm2 facilitates the association of p53 with the proteasome.	PSMC5 CBL	5.73e-05	12	33	2	20479273
Pubmed	miRNAs control tracheal chondrocyte differentiation.	SOX6 DICER1	5.73e-05	12	33	2	21945074
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	ZNF622 MRPS7 DICER1 NRP1	9.19e-05	251	33	4	28077445
Pubmed	Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae.	PREX1 VAV2	1.18e-04	17	33	2	21257963
Pubmed	Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.	CBL VAV2	1.32e-04	18	33	2	19531499
Pubmed	Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy.	PSMC5 RPS3A	1.32e-04	18	33	2	30498063
Pubmed	miRNAs are Essential for the Survival and Maturation of Cortical Interneurons.	SOX6 DICER1	1.48e-04	19	33	2	24451661
Pubmed	Proteomic analysis of the NOS2 interactome in human airway epithelial cells.	PSMC5 DICER1 RPS3A	3.06e-04	138	33	3	23438482
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	RAD51AP2 MRPS7 CLPTM1L CBL PREX1	3.17e-04	638	33	5	31182584
Pubmed	Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors.	SOX6 NRP1	3.25e-04	28	33	2	21658586
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	ZNF704 MRPS7 MAOA CBL DNAH6 RPS3A NRP1	3.57e-04	1451	33	7	30550785
Pubmed	Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation.	ZNF521 NRP1	3.99e-04	31	33	2	36476860
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DNAJC18 ZNF622 MRPS7 CLPTM1L DICER1 RPS3A USP33	4.14e-04	1487	33	7	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF704 FNBP1L PAN3 CAMTA1 MAOA VAV2 NRP1	4.17e-04	1489	33	7	28611215
Pubmed	Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.	CBL VAV2	4.53e-04	33	33	2	18271526
Pubmed	An investigation into the human serum "interactome".	CAMTA1 DICER1 PDZRN4	4.88e-04	162	33	3	15174051
Pubmed	Diversification of stem cell molecular repertoire by alternative splicing.	ZNF704 CCDC112	5.09e-04	35	33	2	16183747
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	PSMC5 RPS3A NRP1	5.62e-04	170	33	3	16159877
Pubmed	Mutation of ARHGAP9 in patients with coronary spastic angina.	PREX1 VAV2	6.01e-04	38	33	2	19911011
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	PREX1 VAV2	6.01e-04	38	33	2	11756498
Pubmed	Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.	ZNF622 MRPS7 RPS3A	7.53e-04	188	33	3	29721183
Pubmed	NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.	PREX1 VAV2	7.69e-04	43	33	2	12376548
Cytoband	Ensembl 112 genes in cytogenetic band chr11q11	OR4A16 OR4A15	3.84e-04	40	33	2	chr11q11
Cytoband	11q11	OR4A16 OR4A15	5.31e-04	47	33	2	11q11
Coexpression	GSE5589_WT_VS_IL6_KO_LPS_AND_IL6_STIM_MACROPHAGE_45MIN_UP	ZNF521 RNASEL DPP8 GINM1 NRP1	4.09e-06	199	32	5	M6645
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron\|World / Primary Cells by Cluster	SOX6 ZNF704 RPS3A PDZRN4	1.17e-05	191	33	4	4dd9c8117c4499ed9bde127baf2598603a82080d
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-SST-MGE1\|World / Primary Cells by Cluster	SOX6 ZNF704 RPS3A PDZRN4	1.19e-05	192	33	4	bcc499f4c7ba2898ecd9c47bf68c92ed359b81ba
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-SST-MGE1-4\|World / Primary Cells by Cluster	SOX6 ZNF704 RPS3A PDZRN4	1.22e-05	193	33	4	2eb6e4cff4fe3ce564c1581f6f7df4834895aaa9
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal-INs\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	ZNF704 CCDC112 FNBP1L PDZRN4	1.29e-05	196	33	4	556e18eae05bf19259fe02848bcc9120aa2a9d29
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_3\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	ZNF704 FNBP1L RPS3A PDZRN4	1.32e-05	197	33	4	d77bc37a77546a1f0a508486a38a45e571e4645b
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_3\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	SOX6 ZNF704 RPS3A PDZRN4	1.32e-05	197	33	4	62c0682eb32a41c58d31ae33b23e7d61ce5a6abb
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn-35\|World / Primary Cells by Cluster	ZNF704 FNBP1L NRP1 PDZRN4	1.35e-05	198	33	4	de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M\|organoid_Kanton_Nature / Sample Type, Dataset, Time_group, and Cell type.	SOX6 CCDC112 FNBP1L PDZRN4	1.37e-05	199	33	4	b2d7dea11207cca63d688f8051143850b29dbdf0
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SOX6 ZNF521 ATP8B2 PDZRN4	1.40e-05	200	33	4	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon-Neuronal\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	ZNF704 CCDC112 FNBP1L RPS3A	1.40e-05	200	33	4	7534005613ee22aee2bac51070929957dece3c8b
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SOX6 ZNF521 ATP8B2 PDZRN4	1.40e-05	200	33	4	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	droplet-Marrow-BM-30m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX6 GDPD3 NRP1	2.23e-04	160	33	3	822adcf5f9208f305cafffd8ed97f3a061e82b03
ToppCell	droplet-Marrow-BM-30m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX6 GDPD3 NRP1	2.31e-04	162	33	3	76e289ad9fd3694f77fd0d19e74c1cb8e87b8094
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF704 RAD51AP2 PDZRN4	2.39e-04	164	33	3	b895674ed2df87db8fbfb30b7e31620945588491
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_ETV4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VAV2 NRP1 PDZRN4	2.61e-04	169	33	3	716e9d4c5fb99c56b76afaa5ed90bfa859fde802
ToppCell	E18.5-Immune-Immune_Myeloid-Granulocytic-Basophil\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF704 RNASEL PREX1	2.61e-04	169	33	3	b23d0aaa2da333b9c69a7aee862d5a5d2a1bf79b
ToppCell	E18.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF704 RNASEL PREX1	2.61e-04	169	33	3	83d1bcf33872b01ea9614f608a3e4ab30df25c7e
ToppCell	3'_v3-blood-Mast\|blood / Manually curated celltypes from each tissue	ZNF521 ZNF704 FNBP1L	2.75e-04	172	33	3	e7a46bbeff749ca59b9f1357409ce1ad59dd22dd
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VAV2 NRP1 PDZRN4	2.85e-04	174	33	3	7d4b860e05b5931f6f9d757a68f75ff35597a47a
ToppCell	3'_v3-blood-Mast-Mast_cells\|blood / Manually curated celltypes from each tissue	ZNF521 ZNF704 FNBP1L	2.95e-04	176	33	3	b9da3deaf62622d47eb30b6be7548253eee95597
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FNBP1L NRP1 PDZRN4	2.99e-04	177	33	3	57033ee0d49a4a50fc25328a4a44d4de2b35f505
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF521 FNBP1L NRP1	3.09e-04	179	33	3	124da6f882968dc0d05f3edd8f3b4d61617cc214
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF521 FNBP1L NRP1	3.09e-04	179	33	3	edc5ef693dc4e7ea70717b77fb908fc784dce3a2
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF521 DNAJC18 PREX1	3.09e-04	179	33	3	8f9e538c822940785130297712b75131812a4603
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VAV2 NRP1 PDZRN4	3.15e-04	180	33	3	e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VAV2 NRP1 PDZRN4	3.25e-04	182	33	3	72e65a23cd36085bc880087d3cae92395de918a1
ToppCell	pdx-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SOX6 ZNF521 NRP1	3.25e-04	182	33	3	7b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VAV2 NRP1 PDZRN4	3.25e-04	182	33	3	05c167158815bf25d509df59ab386e1990712765
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175\|Adult / Lineage, Cell type, age group and donor	ZNF521 DNAJC18 PREX1	3.25e-04	182	33	3	8b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-SST-MGE1-3\|World / Primary Cells by Cluster	SOX6 ZNF704 PDZRN4	3.35e-04	184	33	3	907ba412166bcb0526c5be0b06a76b6bd37c5a35
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX6 FNBP1L VAV2	3.35e-04	184	33	3	2ba98708dfd7f1b2a661578a334684094ff453ad
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SOX6 ZNF521 ATP8B2	3.41e-04	185	33	3	b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FNBP1L DPP8 NRP1	3.46e-04	186	33	3	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	343B-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FNBP1L MAOA PREX1	3.46e-04	186	33	3	080e56113b89138277a2bd2eabddfa6cd1a18b61
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAOA VAV2 NRP1	3.46e-04	186	33	3	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	343B-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FNBP1L MAOA PREX1	3.46e-04	186	33	3	dae6a98963c78bf7518ebab8dc02f173c3b0f7f7
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAOA VAV2 NRP1	3.52e-04	187	33	3	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	Healthy-HSPC\|World / disease group, cell group and cell class	ZNF521 ZNF704 PDZRN4	3.52e-04	187	33	3	8cd9e5499e5c2b2321ecbcf780df37fe0f165ac9
ToppCell	Healthy-HSPC\|Healthy / disease group, cell group and cell class	ZNF521 ZNF704 PDZRN4	3.63e-04	189	33	3	214b225effc40ca1b83dd8052f2a7b80b65d4938
ToppCell	Non-neuronal-Postmitotic-Red_blood_cells-Low_Quality-14\|World / Primary Cells by Cluster	FNBP1L PREX1 RPS3A	3.68e-04	190	33	3	feadd834d843f952aa7ced93899fd1f0868743df
ToppCell	Non-neuronal-Postmitotic-Red_blood_cells-Low_Quality\|World / Primary Cells by Cluster	FNBP1L PREX1 RPS3A	3.68e-04	190	33	3	31cf1367db5c04242621f7c98a10d094bc519e31
ToppCell	Control-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	MAOA PREX1 NRP1	3.68e-04	190	33	3	7f3f419fffe02934b6f27b697f7a6401072491ed
ToppCell	Non-neuronal-Postmitotic-Red_blood_cells\|World / Primary Cells by Cluster	FNBP1L PREX1 RPS3A	3.68e-04	190	33	3	f0b82334375749d917e440c493f10340c52ea13c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX6 ZNF704 VAV2	3.74e-04	191	33	3	9c0ee270209b02043393416ecc9a81ddedfbb8b6
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	SOX6 PAN3 NRP1	3.80e-04	192	33	3	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX6 ZNF704 VAV2	3.86e-04	193	33	3	d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX6 ZNF704 VAV2	3.92e-04	194	33	3	1bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX6 FNBP1L VAV2	3.92e-04	194	33	3	4f758718a1233c25c25d99fc1b7b06f906b8b0a2
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF521 DNAJC18 PREX1	3.92e-04	194	33	3	74a9fdb73f279bebb6337510deab9aaaf9f7e957
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Newborn\|World / Primary Cells by Cluster	ZNF704 FNBP1L NRP1	4.03e-04	196	33	3	9401bd84798f0ea3e986e94135a9e1dc5643330f
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38\|World / Primary Cells by Cluster	ZNF704 PREX1 NRP1	4.03e-04	196	33	3	38da0751941adca650fe9b383d9f343153978eb5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF521 DNAJC18 PREX1	4.03e-04	196	33	3	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	IPF-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	FNBP1L MAOA PREX1	4.03e-04	196	33	3	8f0f72ead06abe02b575e443552eacc2151077ef
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF521 DNAJC18 PREX1	4.03e-04	196	33	3	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-IPC/newborn\|World / Primary Cells by Cluster	ZNF704 PREX1 NRP1	4.03e-04	196	33	3	721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCell	COPD-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	FNBP1L MAOA PREX1	4.09e-04	197	33	3	30dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	ZNF704 CCDC112 FNBP1L	4.16e-04	198	33	3	076c862f2a723f0361749377561cae902068b1a0
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-Immature_CPNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	ZNF704 RPS3A NRP1	4.16e-04	198	33	3	32d58379a89be19b6b1a494bf033416546771c19
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF521 DNAJC18 PDZRN4	4.22e-04	199	33	3	3a4deea6e11a0555d27497b7c9983350797aac69
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	FNBP1L RPS3A PDZRN4	4.22e-04	199	33	3	a255484ba77bd2741a541da278efc8cf4abbe570
ToppCell	Control-Control-Others-HSPC\|Control / Disease, condition lineage and cell class	ZNF521 ZNF704 FNBP1L	4.22e-04	199	33	3	b71169be0d916b2ed139a3122d78bb154c71edb4
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SOX6 ZNF521 PDZRN4	4.22e-04	199	33	3	abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SOX6 ZNF521 PDZRN4	4.28e-04	200	33	3	b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Neuronal-Neurons\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	CCDC112 FNBP1L NRP1	4.28e-04	200	33	3	b9538eb33ac86384e7e289a5a82fac4d56a7b9c2
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Monocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CBL PREX1 VAV2	4.28e-04	200	33	3	8872d5fa101d413fb43b4231d476878678543035
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CCDC112 FNBP1L PDZRN4	4.28e-04	200	33	3	306926cb7a847871641f02e03d52dc56fd55711c
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF521 NRP1 PDZRN4	4.28e-04	200	33	3	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	Neuronal-Excitatory-eD(FEZF2)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	ZNF704 NRP1 PDZRN4	4.28e-04	200	33	3	1b485ff2435c6732be58cbc9eb2f5c273f9c4bf2
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SOX6 ZNF521 PDZRN4	4.28e-04	200	33	3	a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Interneuron\|3m / Sample Type, Dataset, Time_group, and Cell type.	ZNF704 RPS3A PDZRN4	4.28e-04	200	33	3	a313b9a8bde1ea80a6eae183b76fba46b86558b4
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CYP4X1 CCDC112 PDZRN4	4.28e-04	200	33	3	be46efc899d06c55ee297bee3126f69bcdb2048b
ToppCell	Bronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SOX6 ZNF521 PDZRN4	4.28e-04	200	33	3	7c673ad0ea503ebd196579684d25d5f9e6a41030
Disease	C-reactive protein measurement	SOX6 FNBP1L CAMTA1 CBL RPS3A ATP8B2 OR4A16 OR4A15 MSL2	3.70e-06	1206	32	9	EFO_0004458
Disease	red blood cell density measurement	SOX6 ZNF704 FNBP1L CAMTA1 DPP8 PREX1 ATP8B2	3.59e-05	880	32	7	EFO_0007978
Disease	viral load	ZNF704 DNAJC18 VAV2	4.31e-04	136	32	3	EFO_0010125
Disease	lung non-small cell carcinoma (is_implicated_in)	CLPTM1L CBL NRP1	4.59e-04	139	32	3	DOID:3908 (is_implicated_in)
Disease	Endometrioma	MAOA DICER1 NRP1	7.04e-04	161	32	3	C0269102
Disease	Endometriosis	MAOA DICER1 NRP1	7.04e-04	161	32	3	C0014175
Disease	amino acid measurement	SOX6 ZNF704 DNAJC18 RAD51AP2 CAMTA1	7.60e-04	678	32	5	EFO_0005134
Disease	Diuretic use measurement	SOX6 OR4A16 OR4A15	8.10e-04	169	32	3	EFO_0009928
Disease	Alzheimer's disease (implicated_via_orthology)	SOX6 PSMC5	1.75e-03	57	32	2	DOID:10652 (implicated_via_orthology)
Disease	physical activity	ZNF521 FBXO47	4.12e-03	88	32	2	EFO_0003940
Disease	susceptibility to plantar warts measurement	CLPTM1L CAMTA1	4.30e-03	90	32	2	EFO_0008406
Disease	nevus count, cutaneous melanoma	SOX6 CLPTM1L	4.39e-03	91	32	2	EFO_0000389, EFO_0004632
Disease	hypertrophic cardiomyopathy	CCDC112 DNAJC18	4.49e-03	92	32	2	EFO_0000538
Disease	total cholesterol measurement, high density lipoprotein cholesterol measurement	FNBP1L OR4A15 MSL2	4.75e-03	315	32	3	EFO_0004574, EFO_0004612
Disease	reaction time measurement	SOX6 ZNF521 CAMTA1 PDZRN4	5.37e-03	658	32	4	EFO_0008393
Disease	mean corpuscular hemoglobin concentration	SOX6 PAN3 DPP8 PREX1 GDPD3	6.34e-03	1105	32	5	EFO_0004528

Protein segments in the cluster

Peptide	Gene	Start	Entry
MQKDSEKNMSIKKLW	PSMC5	391	P62195
VCEKMMSRACWAKSK	CAMTA1	1041	Q9Y6Y1
EAWKKQKSIEMSMKC	CCDC112	276	Q8NEF3
KWEKDEMTKDCMLAN	DICER1	1396	Q9UPY3
INWDKKMFCMKKRTP	ATP8B2	376	P98198
CKTKCENMKKTEEKW	RAD51AP2	416	Q09MP3
CKESQKCSEPKMEWK	PDZRN4	876	Q6ZMN7
KWDKMTMKELIDKIC	MAOA	151	P21397
SSYKVMCQWMEKFRK	GINM1	236	Q9NU53
EMKSAMRKLWSKKVS	OR4A15	321	Q8NGL6
EMKNAMKNLWCEKLS	OR4A16	291	Q8NH70
IWASEKSSVMKKCKA	GDPD3	176	Q7L5L3
KGKKMMMKPSCSWCK	MSL2	71	Q9HCI7
WKMIMDDSKRKAKSF	NRP1	526	O14786
TKCMVLVDMWKKIQH	PAN3	531	Q58A45
VEKVSKACKSMCMWV	DNAH6	2871	Q9C0G6
LDMCWKQMDNSKKKF	FNBP1L	126	Q5T0N5
MWKRSEQMKIKSGKC	DPP8	1	Q6V1X1
KMMLDKWEKICSTQD	CYP4X1	161	Q8N118
CMKAQKEKKSENEWT	DNAJC18	41	Q9H819
DWTVKMMQKVCKVFS	FBXO47	371	Q5MNV8
VDKKMVEKCWKLMDK	CBL	51	P22681
FLAMKWMITECRDKK	MRPS7	181	Q9Y2R9
TRDKMCSMVKKWQTM	RPS3A	106	P61247
KNKWFVCMAKTAEEK	PREX1	366	Q8TCU6
KWTTKINECVMKKMN	RNASEL	631	Q05823
SCMEKLLSKDWKEKM	SOX6	151	P35712
FWKKKKSMIGMSTKA	CLPTM1L	311	Q96KA5
RMEDWKMKDTQKCSQ	ZNF521	236	Q96K83
KNSMKVMFKCLWKNC	ZNF704	186	Q6ZNC4
MKSKWMLKTGMKNNA	ZNF622	451	Q969S3
QFFCKTEDMKRKWME	VAV2	491	P52735
NSEMSKDWQKEKMCN	USP33	356	Q8TEY7