Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellular matrix structural constituent	CRELD2 LAMB1 CRELD1 FRAS1 THBS1 THBS3 FBN1 FBN2 EDIL3 FBN3	1.20e-12	188	37	10	GO:0005201
GeneOntologyMolecularFunction	calcium ion binding	CRELD2 CRELD1 THBS1 THBS3 FBN1 FBN2 SUSD1 EDIL3 PLA2G12B FBN3	7.21e-07	749	37	10	GO:0005509
GeneOntologyMolecularFunction	structural molecule activity	CRELD2 LAMB1 CRELD1 FRAS1 THBS1 THBS3 FBN1 FBN2 EDIL3 FBN3	3.45e-06	891	37	10	GO:0005198
GeneOntologyMolecularFunction	integrin binding	LAMB1 ESM1 THBS1 FBN1 EDIL3	1.70e-05	175	37	5	GO:0005178
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	FBN1 FBN2	2.18e-04	12	37	2	GO:0030023
GeneOntologyMolecularFunction	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	POU5F1 ZNF350	2.57e-04	13	37	2	GO:0001162
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	FBN1 FBN2	3.00e-04	14	37	2	GO:0097493
GeneOntologyMolecularFunction	intronic transcription regulatory region sequence-specific DNA binding	POU5F1 ZNF350	4.46e-04	17	37	2	GO:0001161
GeneOntologyMolecularFunction	intramolecular oxidoreductase activity, transposing S-S bonds	CRELD2 CRELD1	7.54e-04	22	37	2	GO:0016864
GeneOntologyMolecularFunction	protein disulfide isomerase activity	CRELD2 CRELD1	7.54e-04	22	37	2	GO:0003756
GeneOntologyMolecularFunction	metalloendopeptidase activity	PAPPA2 PAPPA ADAM19	1.42e-03	120	37	3	GO:0004222
GeneOntologyMolecularFunction	cell adhesion molecule binding	LAMB1 ESM1 THBS1 FBN1 EDIL3	4.71e-03	599	37	5	GO:0050839
GeneOntologyMolecularFunction	intramolecular oxidoreductase activity	CRELD2 CRELD1	5.00e-03	57	37	2	GO:0016860
GeneOntologyMolecularFunction	heparin binding	THBS1 THBS3 FBN1	5.35e-03	192	37	3	GO:0008201
GeneOntologyMolecularFunction	isomerase activity	CRELD2 CRELD1 TOP3A	5.35e-03	192	37	3	GO:0016853
GeneOntologyMolecularFunction	metallopeptidase activity	PAPPA2 PAPPA ADAM19	5.99e-03	200	37	3	GO:0008237
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	1.77e-05	4	36	2	GO:0035583
GeneOntologyBiologicalProcess	maintenance of protein location in extracellular region	FBN1 FBN2	8.24e-05	8	36	2	GO:0071694
GeneOntologyBiologicalProcess	sequestering of extracellular ligand from receptor	FBN1 FBN2	1.61e-04	11	36	2	GO:0035581
GeneOntologyBiologicalProcess	extracellular regulation of signal transduction	FBN1 FBN2	2.28e-04	13	36	2	GO:1900115
GeneOntologyBiologicalProcess	extracellular negative regulation of signal transduction	FBN1 FBN2	2.28e-04	13	36	2	GO:1900116
GeneOntologyBiologicalProcess	bone trabecula formation	THBS3 FBN2	2.66e-04	14	36	2	GO:0060346
GeneOntologyBiologicalProcess	positive regulation of integrin-mediated signaling pathway	PCSK5 LAMB1	2.66e-04	14	36	2	GO:2001046
GeneOntologyCellularComponent	extracellular matrix	LAMB1 CRELD1 FRAS1 THBS1 THBS3 FBN1 ADAM19 FBN2 ZAN EDIL3 FBN3	1.09e-08	656	37	11	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	LAMB1 CRELD1 FRAS1 THBS1 THBS3 FBN1 ADAM19 FBN2 ZAN EDIL3 FBN3	1.12e-08	658	37	11	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	LAMB1 CRELD1 FRAS1 THBS1 THBS3 FBN1 ADAM19 FBN2 EDIL3	2.67e-07	530	37	9	GO:0062023
GeneOntologyCellularComponent	microfibril	FBN1 FBN2 FBN3	1.44e-06	13	37	3	GO:0001527
GeneOntologyCellularComponent	basement membrane	LAMB1 FRAS1 FBN1	1.30e-03	122	37	3	GO:0005604
GeneOntologyCellularComponent	endoplasmic reticulum lumen	PCSK5 LAMB1 THBS1 FBN1	2.73e-03	332	37	4	GO:0005788
HumanPheno	Abnormal upper to lower segment ratio	FBN1 FBN2	1.52e-05	3	12	2	HP:0012772
MousePheno	abnormal pelvic girdle bone morphology	PAPPA2 PCSK5 PAPPA FBN1 FBN2	6.03e-07	87	27	5	MP:0004509
MousePheno	abnormal hindlimb morphology	PAPPA2 PCSK5 PAPPA FNDC3A FRAS1 THBS1 THBS3 FBN1 FBN2	7.75e-07	576	27	9	MP:0000556
MousePheno	abnormal interdigital cell death	FRAS1 FBN2	3.58e-05	5	27	2	MP:0009874
MousePheno	abnormal tibia morphology	PAPPA2 PCSK5 PAPPA FNDC3A FBN1 FBN2	6.57e-05	375	27	6	MP:0000558
MousePheno	limbs/digits/tail phenotype	PAPPA2 PCSK5 LAMB1 PAPPA FNDC3A FRAS1 THBS1 THBS3 FBN1 FBN2	6.80e-05	1258	27	10	MP:0005371
MousePheno	abnormal hindlimb zeugopod morphology	PAPPA2 PCSK5 PAPPA FNDC3A FBN1 FBN2	7.18e-05	381	27	6	MP:0003857
MousePheno	abnormal limb long bone morphology	PAPPA2 PCSK5 PAPPA FNDC3A THBS3 FBN1 FBN2	7.69e-05	568	27	7	MP:0011504
MousePheno	abnormal limb morphology	PAPPA2 PCSK5 PAPPA FNDC3A FRAS1 THBS1 THBS3 FBN1 FBN2	8.47e-05	1028	27	9	MP:0002109
MousePheno	abnormal limb bone morphology	PAPPA2 PCSK5 PAPPA FNDC3A THBS3 FBN1 FBN2	9.46e-05	587	27	7	MP:0002115
MousePheno	abnormal appendicular skeleton morphology	PAPPA2 PCSK5 PAPPA FNDC3A FRAS1 THBS3 FBN1 FBN2	2.05e-04	896	27	8	MP:0009250
MousePheno	abnormal long bone morphology	PAPPA2 PCSK5 PAPPA FNDC3A THBS3 FBN1 FBN2	2.28e-04	676	27	7	MP:0003723
MousePheno	embryonic lethality between implantation and somite formation, complete penetrance	PCSK5 LAMB1 POU5F1 FBN1 TOP3A	2.85e-04	311	27	5	MP:0011096
MousePheno	abnormal forelimb morphology	PAPPA2 PCSK5 FBN1 FBN2	3.86e-04	182	27	4	MP:0000550
MousePheno	embryonic lethality between implantation and somite formation	PCSK5 LAMB1 POU5F1 FBN1 TOP3A	4.29e-04	340	27	5	MP:0006205
MousePheno	abnormal diaphragm morphology	CHAT FBN1 ADAM19	4.44e-04	78	27	3	MP:0002279
MousePheno	abnormal lung vasculature morphology	FRAS1 THBS1 FBN1	4.44e-04	78	27	3	MP:0004007
MousePheno	abnormal radius morphology	PAPPA2 FBN1 FBN2	5.14e-04	82	27	3	MP:0000552
MousePheno	decreased atrioventricular cushion size	CRELD1 ADAM19	5.39e-04	18	27	2	MP:0000301
MousePheno	abnormal ulna morphology	PAPPA2 FBN1 FBN2	5.52e-04	84	27	3	MP:0005108
MousePheno	abnormal vertebral column morphology	PAPPA2 PCSK5 CHAT FRAS1 THBS1 FBN1 FBN2	5.75e-04	787	27	7	MP:0004703
MousePheno	abnormal femur morphology	PAPPA2 PCSK5 THBS3 FBN2	7.11e-04	214	27	4	MP:0000559
MousePheno	abnormal hindlimb stylopod morphology	PAPPA2 PCSK5 THBS3 FBN2	7.23e-04	215	27	4	MP:0003856
MousePheno	syndactyly	PCSK5 FRAS1 FBN2	7.43e-04	93	27	3	MP:0000564
MousePheno	abnormal digit development	FRAS1 FBN2	8.86e-04	23	27	2	MP:0006280
MousePheno	abnormal tail morphology	PAPPA2 PCSK5 LAMB1 FRAS1 FBN2	9.28e-04	403	27	5	MP:0002111
MousePheno	abnormal forelimb zeugopod morphology	PAPPA2 FBN1 FBN2	9.71e-04	102	27	3	MP:0003855
Domain	EGF-like_dom	PCSK5 CRELD2 LAMB1 CRELD1 FRAS1 THBS1 THBS3 FBN1 ADAM19 FBN2 ZAN SUSD1 EDIL3 ATRNL1 FBN3	3.53e-19	249	37	15	IPR000742
Domain	EGF	PCSK5 CRELD2 LAMB1 CRELD1 FRAS1 THBS1 THBS3 FBN1 FBN2 ZAN SUSD1 EDIL3 ATRNL1 FBN3	7.98e-18	235	37	14	SM00181
Domain	EGF_1	CRELD2 LAMB1 CRELD1 THBS1 THBS3 FBN1 ADAM19 FBN2 ZAN SUSD1 EDIL3 ATRNL1 FBN3	1.12e-15	255	37	13	PS00022
Domain	EGF-like_CS	CRELD2 LAMB1 CRELD1 THBS1 THBS3 FBN1 ADAM19 FBN2 ZAN SUSD1 EDIL3 ATRNL1 FBN3	1.52e-15	261	37	13	IPR013032
Domain	EGF_2	CRELD2 LAMB1 CRELD1 THBS1 THBS3 FBN1 ADAM19 FBN2 ZAN SUSD1 EDIL3 ATRNL1 FBN3	1.85e-15	265	37	13	PS01186
Domain	Growth_fac_rcpt_	PCSK5 CRELD2 LAMB1 ESM1 CRELD1 FRAS1 THBS3 FBN1 FBN2 SUSD1 FBN3	6.85e-15	156	37	11	IPR009030
Domain	EGF_3	CRELD2 CRELD1 THBS1 THBS3 FBN1 ADAM19 FBN2 ZAN SUSD1 EDIL3 ATRNL1 FBN3	1.67e-14	235	37	12	PS50026
Domain	EGF_CA	CRELD2 CRELD1 THBS1 THBS3 FBN1 FBN2 SUSD1 EDIL3 FBN3	1.71e-12	122	37	9	SM00179
Domain	EGF-like_Ca-bd_dom	CRELD2 CRELD1 THBS1 THBS3 FBN1 FBN2 SUSD1 EDIL3 FBN3	1.99e-12	124	37	9	IPR001881
Domain	EGF_CA	CRELD2 CRELD1 THBS1 THBS3 FBN1 FBN2 SUSD1 FBN3	5.02e-12	86	37	8	PF07645
Domain	EGF_Ca-bd_CS	CRELD2 CRELD1 THBS3 FBN1 FBN2 SUSD1 EDIL3 FBN3	1.35e-11	97	37	8	IPR018097
Domain	EGF_CA	CRELD2 CRELD1 THBS3 FBN1 FBN2 SUSD1 EDIL3 FBN3	1.59e-11	99	37	8	PS01187
Domain	ASX_HYDROXYL	CRELD2 CRELD1 FBN1 FBN2 SUSD1 EDIL3 FBN3	9.20e-10	100	37	7	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	CRELD2 CRELD1 FBN1 FBN2 SUSD1 EDIL3 FBN3	1.39e-09	106	37	7	IPR000152
Domain	FBN	FBN1 FBN2 FBN3	7.16e-09	3	37	3	IPR011398
Domain	Furin_repeat	PCSK5 CRELD2 CRELD1 FRAS1	3.91e-08	18	37	4	IPR006212
Domain	FU	PCSK5 CRELD2 CRELD1 FRAS1	3.91e-08	18	37	4	SM00261
Domain	TB	FBN1 FBN2 FBN3	2.49e-07	7	37	3	PF00683
Domain	-	FBN1 FBN2 FBN3	3.98e-07	8	37	3	3.90.290.10
Domain	TB	FBN1 FBN2 FBN3	5.96e-07	9	37	3	PS51364
Domain	TB_dom	FBN1 FBN2 FBN3	5.96e-07	9	37	3	IPR017878
Domain	Laminin_EGF	CRELD2 LAMB1 CRELD1 ATRNL1	9.17e-07	38	37	4	IPR002049
Domain	Peptidase_M43	PAPPA2 PAPPA	3.82e-06	2	37	2	IPR008754
Domain	Peptidase_M43	PAPPA2 PAPPA	3.82e-06	2	37	2	PF05572
Domain	Myxo_disulph_rpt	PAPPA2 PAPPA	1.14e-05	3	37	2	IPR011936
Domain	cEGF	FBN1 FBN2 FBN3	1.80e-05	26	37	3	IPR026823
Domain	cEGF	FBN1 FBN2 FBN3	1.80e-05	26	37	3	PF12662
Domain	hEGF	FBN2 EDIL3 FBN3	2.27e-05	28	37	3	PF12661
Domain	LamGL	PAPPA2 PAPPA	2.29e-05	4	37	2	SM00560
Domain	LamG-like	PAPPA2 PAPPA	2.29e-05	4	37	2	IPR006558
Domain	-	PAPPA2 PAPPA THBS1 THBS3	3.65e-05	95	37	4	2.60.120.200
Domain	TSP3	THBS1 THBS3	3.80e-05	5	37	2	PS51234
Domain	TSP_CTER	THBS1 THBS3	3.80e-05	5	37	2	PS51236
Domain	-	THBS1 THBS3	3.80e-05	5	37	2	4.10.1080.10
Domain	Thrombospondin_C	THBS1 THBS3	3.80e-05	5	37	2	IPR008859
Domain	TSP_C	THBS1 THBS3	3.80e-05	5	37	2	PF05735
Domain	Thrombospondin_3_rpt	THBS1 THBS3	3.80e-05	5	37	2	IPR017897
Domain	TSP_3	THBS1 THBS3	3.80e-05	5	37	2	PF02412
Domain	Thrombospondin_3-like_rpt	THBS1 THBS3	3.80e-05	5	37	2	IPR003367
Domain	TSP_type-3_rpt	THBS1 THBS3	3.80e-05	5	37	2	IPR028974
Domain	VWFC_1	FRAS1 THBS1 ZAN	4.88e-05	36	37	3	PS01208
Domain	VWC	FRAS1 THBS1 ZAN	5.76e-05	38	37	3	SM00214
Domain	VWFC_2	FRAS1 THBS1 ZAN	5.76e-05	38	37	3	PS50184
Domain	ConA-like_dom	PAPPA2 PAPPA THBS1 THBS3 ZAN	6.80e-05	219	37	5	IPR013320
Domain	VWF_dom	FRAS1 THBS1 ZAN	7.79e-05	42	37	3	IPR001007
Domain	Notch_dom	PAPPA2 PAPPA	7.97e-05	7	37	2	IPR000800
Domain	DUF3456	CRELD2 CRELD1	7.97e-05	7	37	2	IPR021852
Domain	Notch	PAPPA2 PAPPA	7.97e-05	7	37	2	PF00066
Domain	DUF3456	CRELD2 CRELD1	7.97e-05	7	37	2	PF11938
Domain	NL	PAPPA2 PAPPA	7.97e-05	7	37	2	SM00004
Domain	Sushi	PAPPA2 PAPPA SUSD1	1.48e-04	52	37	3	PF00084
Domain	CCP	PAPPA2 PAPPA SUSD1	1.66e-04	54	37	3	SM00032
Domain	SUSHI	PAPPA2 PAPPA SUSD1	1.85e-04	56	37	3	PS50923
Domain	Sushi_SCR_CCP_dom	PAPPA2 PAPPA SUSD1	1.95e-04	57	37	3	IPR000436
Domain	EGF_extracell	ADAM19 EDIL3 ATRNL1	2.27e-04	60	37	3	IPR013111
Domain	EGF_2	ADAM19 EDIL3 ATRNL1	2.27e-04	60	37	3	PF07974
Domain	MetalloPept_cat_dom	PAPPA2 PAPPA ADAM19	5.49e-04	81	37	3	IPR024079
Domain	-	PAPPA2 PAPPA ADAM19	5.49e-04	81	37	3	3.40.390.10
Domain	VWC_out	FRAS1 ZAN	6.39e-04	19	37	2	SM00215
Domain	Galactose-bd-like	PCSK5 LAMB1 EDIL3	8.47e-04	94	37	3	IPR008979
Domain	TSPN	THBS1 THBS3	9.41e-04	23	37	2	SM00210
Domain	ZINC_PROTEASE	PAPPA2 PAPPA ADAM19	9.56e-04	98	37	3	PS00142
Domain	VWC	FRAS1 THBS1	1.40e-03	28	37	2	PF00093
Domain	EGF_LAM_2	LAMB1 ATRNL1	1.60e-03	30	37	2	PS50027
Domain	EGF_LAM_1	LAMB1 ATRNL1	1.60e-03	30	37	2	PS01248
Domain	EGF	ZAN EDIL3 FBN3	1.97e-03	126	37	3	PF00008
Domain	Laminin_EGF	LAMB1 CRELD1	2.18e-03	35	37	2	PF00053
Domain	EGF_Lam	LAMB1 ATRNL1	2.18e-03	35	37	2	SM00180
Domain	KRAB	ZNF17 ZNF350 ZNF229 ZNF285	5.32e-03	358	37	4	PS50805
Domain	KRAB	ZNF17 ZNF350 ZNF229 ZNF285	5.32e-03	358	37	4	PF01352
Domain	Laminin_G	THBS1 THBS3	5.89e-03	58	37	2	IPR001791
Domain	KRAB	ZNF17 ZNF350 ZNF229 ZNF285	5.92e-03	369	37	4	SM00349
Pathway	PID_INTEGRIN3_PATHWAY	LAMB1 THBS1 FBN1 EDIL3	9.06e-07	43	25	4	M53
Pathway	WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE	FBN1 FBN2 FBN3	1.10e-05	25	25	3	M39713
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	LAMB1 THBS1 FBN1 ADAM19 FBN2 FBN3	1.11e-05	300	25	6	M610
Pathway	WP_INFLAMMATORY_RESPONSE_PATHWAY	LAMB1 THBS1 THBS3	1.94e-05	30	25	3	MM15812
Pathway	WP_INFLAMMATORY_RESPONSE_PATHWAY	LAMB1 THBS1 THBS3	1.94e-05	30	25	3	M39641
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBN1 FBN2 FBN3	3.68e-05	37	25	3	M27134
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBN1 FBN2 FBN3	6.22e-05	44	25	3	M26969
Pathway	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	PAPPA2 LAMB1 PAPPA FBN1	6.25e-05	124	25	4	M27285
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	LAMB1 FBN1 FBN2 FBN3	1.00e-04	140	25	4	M587
Pathway	PID_INTEGRIN1_PATHWAY	LAMB1 THBS1 FBN1	2.09e-04	66	25	3	M18
Pathway	PID_INTEGRIN5_PATHWAY	FBN1 EDIL3	4.04e-04	17	25	2	M212
Pathway	KEGG_ECM_RECEPTOR_INTERACTION	LAMB1 THBS1 THBS3	4.27e-04	84	25	3	M7098
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	THBS1 FBN1 ADAM19 FBN2	1.02e-03	258	25	4	MM14572
Pathway	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	PAPPA2 PAPPA FBN1	1.21e-03	120	25	3	MM14982
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBN1 FBN2	1.45e-03	32	25	2	MM14854
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBN1 FBN2	2.15e-03	39	25	2	MM14601
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2 FBN3	4.43e-09	4	37	3	25034023
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	CRELD2 LAMB1 CRELD1 THBS1 FBN1 FBN2	3.04e-08	175	37	6	28071719
Pubmed	Comprehensive proteomic characterization of stem cell-derived extracellular matrices.	THBS1 THBS3 FBN1 FBN2 EDIL3	3.37e-08	86	37	5	28327460
Pubmed	Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.	LAMB1 THBS1 FBN1 FBN2	2.41e-07	50	37	4	23658023
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	LAMB1 FBN1 FBN2	8.94e-07	18	37	3	39040056
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	LAMB1 FRAS1 THBS1 FBN1 ADAM19	9.25e-07	167	37	5	22159717
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	THBS1 FBN1 FBN2 ATRNL1	1.00e-06	71	37	4	33541421
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	1.10e-06	2	37	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	1.10e-06	2	37	2	21851253
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	1.10e-06	2	37	2	12429739
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	1.10e-06	2	37	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	1.10e-06	2	37	2	21440062
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	1.10e-06	2	37	2	15131124
Pubmed	Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins.	CRELD2 CRELD1	1.10e-06	2	37	2	12137942
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	1.10e-06	2	37	2	12524050
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	1.10e-06	2	37	2	20404337
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	1.10e-06	2	37	2	8791520
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	1.10e-06	2	37	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	1.10e-06	2	37	2	35419902
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	1.10e-06	2	37	2	8307578
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	1.10e-06	2	37	2	10504303
Pubmed	Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice.	PAPPA2 PAPPA	1.10e-06	2	37	2	21586553
Pubmed	Pregnancy associated plasma protein-A as a prognostic biomarker of all-cause mortality and cardiovascular events in patients presenting with chest pain: a systematic review.	PAPPA2 PAPPA	1.10e-06	2	37	2	29144175
Pubmed	Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.	FBN1 FBN3	1.10e-06	2	37	2	15221638
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	1.10e-06	2	37	2	7744963
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	1.10e-06	2	37	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	1.10e-06	2	37	2	18006876
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	1.10e-06	2	37	2	24833718
Pubmed	Thrombospondin 3 is a developmentally regulated heparin binding protein.	THBS1 THBS3	1.10e-06	2	37	2	8288588
Pubmed	Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3.	THBS1 THBS3	1.10e-06	2	37	2	8654563
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	1.10e-06	2	37	2	24265020
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	1.10e-06	2	37	2	20529844
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	1.10e-06	2	37	2	25524144
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	1.10e-06	2	37	2	23133647
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	1.10e-06	2	37	2	16407178
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	1.10e-06	2	37	2	1852206
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	1.10e-06	2	37	2	10359653
Pubmed	Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin.	PAPPA2 PAPPA	1.10e-06	2	37	2	11513734
Pubmed	Transcriptome-based systematic identification of extracellular matrix proteins.	LAMB1 FRAS1 THBS1 EDIL3	1.54e-06	79	37	4	18757743
Pubmed	Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.	LAMB1 POU5F1 FBN1 ADAM19 FBN2	2.03e-06	196	37	5	19334288
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	LAMB1 FBN1 FBN2	2.83e-06	26	37	3	34189436
Pubmed	Expression and function of thrombospondin-1 in myelinating glial cells of the central nervous system.	THBS1 THBS3	3.30e-06	3	37	2	9373030
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	3.30e-06	3	37	2	10825173
Pubmed	Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR.	PAPPA2 PAPPA	3.30e-06	3	37	2	29532882
Pubmed	Altered placental expression of PAPPA2 does not affect birth weight in mice.	PAPPA2 PAPPA	3.30e-06	3	37	2	20642865
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	3.30e-06	3	37	2	30201140
Pubmed	mRNA Expression of thrombospondin 1, 2 and 3 from proximal to distal in human abdominal aortic aneurysm - preliminary report.	THBS1 THBS3	3.30e-06	3	37	2	34669362
Pubmed	Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.	THBS1 THBS3	3.30e-06	3	37	2	1459996
Pubmed	Differential expression of thrombospondin 1, 2, and 3 during murine development.	THBS1 THBS3	3.30e-06	3	37	2	8400410
Pubmed	Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.	FBN1 FBN2	3.30e-06	3	37	2	20855508
Pubmed	Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients.	PAPPA2 PAPPA	3.30e-06	3	37	2	18805800
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CRELD2 LAMB1 CRELD1 FRAS1 THBS1 THBS3 FBN1 FBN2 EDIL3	3.52e-06	1201	37	9	35696571
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	PCSK5 LAMB1 PAPPA THBS1 FBN1	6.41e-06	248	37	5	24006456
Pubmed	Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.	FBN1 FBN2	6.60e-06	4	37	2	12429738
Pubmed	Human eye development is characterized by coordinated expression of fibrillin isoforms.	FBN1 FBN2	6.60e-06	4	37	2	25406291
Pubmed	Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.	FBN1 FBN2	6.60e-06	4	37	2	20729550
Pubmed	A segregated cortical stream for retinal direction selectivity.	CHAT EDIL3	6.60e-06	4	37	2	32047156
Pubmed	Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.	FBN1 FBN2	6.60e-06	4	37	2	16835936
Pubmed	Immunohistochemical localisation of thrombospondin in human megakaryocytes and platelets.	THBS1 THBS3	6.60e-06	4	37	2	6338048
Pubmed	MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons.	PAPPA2 PAPPA CHAT	7.09e-06	35	37	3	22407321
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	LAMB1 FBN1 FBN2	8.40e-06	37	37	3	34323105
Pubmed	Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.	FBN1 FBN2	1.10e-05	5	37	2	26601954
Pubmed	Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.	THBS1 THBS3	1.10e-05	5	37	2	30622267
Pubmed	Genetic determinants associated with early age of diagnosis of IBD.	LAMB1 POU5F1	1.10e-05	5	37	2	25664710
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	FBN1 FBN2	1.10e-05	5	37	2	12590922
Pubmed	Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen.	THBS1 THBS3	1.10e-05	5	37	2	18467703
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBN1 FBN2	1.10e-05	5	37	2	17255108
Pubmed	POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.	FBN1 FBN2	1.10e-05	5	37	2	34411563
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	FBN1 FBN2	1.10e-05	5	37	2	23493297
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	LAMB1 CRELD1 FBN1 FBN2	1.30e-05	135	37	4	28675934
Pubmed	YY1 Is Required for Posttranscriptional Stability of SOX2 and OCT4 Proteins.	POU5F1 EDIL3	1.65e-05	6	37	2	28682643
Pubmed	High-throughput mammalian two-hybrid screening for protein-protein interactions using transfected cell arrays.	THBS1 FBN2	1.65e-05	6	37	2	18254948
Pubmed	Pcsk5 is required in the early cranio-cardiac mesoderm for heart development.	PCSK5 EDIL3	1.65e-05	6	37	2	28446132
Pubmed	Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.	FBN1 FBN2	1.65e-05	6	37	2	7873879
Pubmed	Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions.	POU5F1 EDIL3	1.65e-05	6	37	2	23142660
Pubmed	The tight-skin (Tsk) mutation is closely linked to B2m on mouse chromosome 2.	THBS1 FBN1	1.65e-05	6	37	2	8111131
Pubmed	SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNΔ7 mouse model of SMA.	CHAT EDIL3	1.65e-05	6	37	2	26206889
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	LAMB1 THBS1 FBN1 EDIL3	1.77e-05	146	37	4	27068509
Pubmed	Protein profile of exosomes from trabecular meshwork cells.	LAMB1 THBS1 EDIL3	1.97e-05	49	37	3	21362503
Pubmed	The primitive endoderm segregates from the epiblast in β1 integrin-deficient early mouse embryos.	POU5F1 EDIL3	2.30e-05	7	37	2	24277939
Pubmed	Regulation of limb patterning by extracellular microfibrils.	FBN1 FBN2	2.30e-05	7	37	2	11470817
Pubmed	Compensatory embryonic response to allele-specific inactivation of the murine X-linked gene Hcfc1.	POU5F1 EDIL3	2.30e-05	7	37	2	26921005
Pubmed	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.	THBS1 FBN1 FBN2	2.36e-05	52	37	3	30389913
Pubmed	Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.	FBN1 FBN2	3.07e-05	8	37	2	23055981
Pubmed	Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.	FBN1 FBN2	3.07e-05	8	37	2	31201465
Pubmed	Retinal transcriptome of neonatal mice after optic nerve injury.	THBS1 FBN1	3.07e-05	8	37	2	37252932
Pubmed	Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear.	THBS1 THBS3	3.07e-05	8	37	2	24460873
Pubmed	Targeting of bone morphogenetic protein growth factor complexes to fibrillin.	FBN1 FBN2	3.07e-05	8	37	2	18339631
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	FBN1 FBN2	3.95e-05	9	37	2	12122015
Pubmed	Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells.	POU5F1 EDIL3	3.95e-05	9	37	2	24448552
Pubmed	Semaphorin 6A in Retinal Ganglion Cells Regulates Functional Specialization of the Inner Retina.	CHAT EDIL3	3.95e-05	9	37	2	38014224
Pubmed	Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.	FBN1 FBN2	3.95e-05	9	37	2	38844137
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	LAMB1 FRAS1 THBS1	4.42e-05	64	37	3	22261194
Pubmed	Functional consequences of cell type-restricted expression of laminin α5 in mouse placental labyrinth and kidney glomerular capillaries.	LAMB1 EDIL3	4.93e-05	10	37	2	22911783
Pubmed	Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.	FBN1 FBN2	4.93e-05	10	37	2	30738849
Pubmed	Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues.	POU5F1 EDIL3	4.93e-05	10	37	2	24168030
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	LAMB1 THBS1 ZNF350 FBN1 ADAM19 EDIL3 ATRNL1 TARS1	5.04e-05	1285	37	8	35914814
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	PAPPA2 PCSK5 PAPPA POU5F1	5.81e-05	198	37	4	20881960
Pubmed	Endogenous retroviruses shape pluripotency specification in mouse embryos.	POU5F1 EDIL3	6.02e-05	11	37	2	38266080
Pubmed	Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice.	CHAT EDIL3	6.02e-05	11	37	2	29972353
Interaction	CFC1 interactions	PCSK5 CRELD2 LAMB1 FRAS1 THBS1 ADAM19	1.05e-07	126	37	6	int:CFC1
Interaction	ZFP41 interactions	CRELD2 FRAS1 FBN1 FBN2	3.54e-06	57	37	4	int:ZFP41
Interaction	HRG interactions	THBS1 POU5F1 FBN1 FBN2	5.30e-06	63	37	4	int:HRG
Interaction	FBXO2 interactions	PCSK5 LAMB1 FRAS1 FBN1 FBN2 SUSD1 EDIL3	8.46e-06	411	37	7	int:FBXO2
Interaction	ZNF134 interactions	TNS2 ZNF134	9.83e-06	3	37	2	int:ZNF134
Interaction	IGFL3 interactions	PCSK5 LAMB1 FRAS1 FBN2	1.06e-05	75	37	4	int:IGFL3
Interaction	NTN5 interactions	FRAS1 FBN1 FBN2	1.12e-05	24	37	3	int:NTN5
Interaction	PRG2 interactions	PCSK5 CRELD2 PAPPA FRAS1 THBS1 FBN2	1.22e-05	285	37	6	int:PRG2
Interaction	GPHA2 interactions	PCSK5 FRAS1 GPT2	1.27e-05	25	37	3	int:GPHA2
Interaction	ST14 interactions	PCSK5 CRELD2 LAMB1 FBN1 FBN2	3.63e-05	207	37	5	int:ST14
Interaction	HOXA1 interactions	PCSK5 CRELD2 ESM1 CRELD1 TNS2 FBN1	4.26e-05	356	37	6	int:HOXA1
Interaction	LY86 interactions	PCSK5 CRELD2 LAMB1 THBS1 ADAM19	4.55e-05	217	37	5	int:LY86
Interaction	LYPD4 interactions	PCSK5 CRELD2 THBS1 FBN2	7.47e-05	123	37	4	int:LYPD4
Interaction	ZDHHC15 interactions	THBS1 FBN1 FBN2 ATRNL1	7.95e-05	125	37	4	int:ZDHHC15
Interaction	TAFA2 interactions	CRELD2 SUSD1 ATRNL1	8.74e-05	47	37	3	int:TAFA2
Interaction	PRG3 interactions	PCSK5 FRAS1 FBN2	9.90e-05	49	37	3	int:PRG3
Interaction	GPIHBP1 interactions	PCSK5 CRELD2 FRAS1 SUSD1	1.01e-04	133	37	4	int:GPIHBP1
Interaction	ATF7IP interactions	PAPPA2 PAPPA ZNF350 SUSD1	1.17e-04	138	37	4	int:ATF7IP
Interaction	ZNF408 interactions	CRELD1 FRAS1 FBN1 FBN2	1.41e-04	145	37	4	int:ZNF408
Interaction	LYPD1 interactions	PCSK5 LAMB1 FRAS1	1.64e-04	58	37	3	int:LYPD1
Interaction	MFAP2 interactions	FBN1 FBN2	2.14e-04	12	37	2	int:MFAP2
Interaction	FBN2 interactions	THBS1 FBN1 FBN2	2.30e-04	65	37	3	int:FBN2
Interaction	SDF2L1 interactions	PCSK5 CRELD2 LAMB1 FRAS1 ADAM19	2.89e-04	322	37	5	int:SDF2L1
Interaction	IGSF5 interactions	CRELD2 LNX2	2.94e-04	14	37	2	int:IGSF5
Interaction	PTPRK interactions	PCSK5 LAMB1 FRAS1 SUSD1	3.03e-04	177	37	4	int:PTPRK
Interaction	ZNF837 interactions	PCSK5 TNS2 ZNF17	4.09e-04	79	37	3	int:ZNF837
Interaction	DYRK1A interactions	LAMB1 TNS2 THBS1 FBN1 ADAM19 ATRNL1	4.64e-04	552	37	6	int:DYRK1A
Interaction	DNAJB9 interactions	PCSK5 LAMB1 THBS1 ADAM19	4.99e-04	202	37	4	int:DNAJB9
Interaction	SIRPD interactions	CRELD2 FRAS1 THBS1	5.25e-04	86	37	3	int:SIRPD
Interaction	THBS2 interactions	THBS1 THBS3	5.50e-04	19	37	2	int:THBS2
Interaction	CCN6 interactions	CRELD2 FRAS1	5.50e-04	19	37	2	int:CCN6
Cytoband	7q22	LAMB1 ZAN	4.36e-04	38	37	2	7q22
Cytoband	19q13.4	ZNF17 ZNF134	1.87e-03	79	37	2	19q13.4
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF17 ZNF134 ZNF350 ZNF229 ZNF285	2.56e-03	1192	37	5	chr19q13
GeneFamily	Pappalysins\|Sushi domain containing	PAPPA2 PAPPA	1.41e-06	2	22	2	897
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PAPPA2 PAPPA SUSD1	4.38e-05	57	22	3	1179
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF17 ZNF134 ZNF350 ZNF229 ZNF285	1.46e-03	718	22	5	28
Coexpression	NABA_CORE_MATRISOME	CRELD2 LAMB1 ESM1 CRELD1 FRAS1 THBS1 THBS3 FBN1 FBN2 EDIL3 FBN3	9.32e-14	275	37	11	M5884
Coexpression	NABA_ECM_GLYCOPROTEINS	CRELD2 LAMB1 CRELD1 FRAS1 THBS1 THBS3 FBN1 FBN2 EDIL3 FBN3	1.27e-13	196	37	10	M3008
Coexpression	NABA_MATRISOME	PAPPA2 PCSK5 CRELD2 LAMB1 ESM1 CRELD1 PAPPA FRAS1 THBS1 THBS3 FBN1 ADAM19 FBN2 EDIL3 FBN3	2.93e-12	1026	37	15	M5889
Coexpression	NABA_CORE_MATRISOME	CRELD2 LAMB1 ESM1 CRELD1 FRAS1 THBS1 THBS3 FBN1 FBN2 EDIL3	3.11e-12	270	37	10	MM17057
Coexpression	NABA_ECM_GLYCOPROTEINS	CRELD2 LAMB1 CRELD1 FRAS1 THBS1 THBS3 FBN1 FBN2 EDIL3	5.00e-12	191	37	9	MM17059
Coexpression	NABA_MATRISOME	PAPPA2 PCSK5 CRELD2 LAMB1 ESM1 CRELD1 PAPPA FRAS1 THBS1 THBS3 FBN1 ADAM19 FBN2 EDIL3	3.78e-11	1008	37	14	MM17056
Coexpression	WATANABE_ULCERATIVE_COLITIS_WITH_CANCER_UP	PCSK5 FBN1 EDIL3	2.47e-06	19	37	3	M12084
Coexpression	LAKE_ADULT_KIDNEY_C16_COLLECTING_SYSTEM_PRINCIPAL_CELLS_CORTEX	LAMB1 PAPPA FNDC3A FRAS1	4.62e-05	141	37	4	M39235
Coexpression	VERRECCHIA_RESPONSE_TO_TGFB1_C4	LAMB1 THBS1	1.06e-04	11	37	2	M566
Coexpression	SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP	LAMB1 ESM1 FBN1 ADAM19 FBN2	1.30e-04	352	37	5	M17471
Coexpression	CHICAS_RB1_TARGETS_CONFLUENT	KCNN2 THBS1 FBN1 ADAM19 FBN2 CHML	1.31e-04	567	37	6	M2129
Coexpression	GSE21927_BALBC_VS_C57BL6_MONOCYTE_SPLEEN_UP	ZNF134 LNX2 ZNF285 SUSD1	1.44e-04	189	37	4	M7569
Coexpression	LEF1_UP.V1_UP	PCSK5 ZNF134 ZNF350 ADAM19	1.59e-04	194	37	4	M2905
Coexpression	HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	THBS1 FBN1 FBN2 EDIL3	1.78e-04	200	37	4	M5930
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#5_top-relative-expression-ranked_1000	PCSK5 PAPPA FNDC3A FBN1 FBN2 ZNF229 EDIL3	3.81e-07	288	35	7	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000_k5
CoexpressionAtlas	MESO-30 blastocyst_vs_MESO-30 amniotic fluid MSC-Confounder_removed-fold2.0_adjp0.05	PCSK5 LAMB1 PAPPA FRAS1 THBS1 ADAM19 SUSD1 EDIL3 PLA2G12B	2.84e-06	761	35	9	PCBC_ratio_MESO-30 blastocyst_vs_MESO-30 amniotic fluid MSC_cfr-2X-p05
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_top-relative-expression-ranked_1000	PCSK5 PAPPA FNDC3A THBS3 FBN1 FBN2 ZNF229 GPT2 EDIL3	3.90e-06	791	35	9	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000
CoexpressionAtlas	kidney_P4_CapMesRenVes_Crym_k-means-cluster#3_top-relative-expression-ranked_500	PAPPA2 LAMB1 FRAS1 FBN2 CHML	7.17e-06	165	35	5	gudmap_kidney_P4_CapMesRenVes_Crym_k3_500
CoexpressionAtlas	placenta	PAPPA2 LAMB1 PAPPA CHAT FBN1 FBN2	2.05e-05	349	35	6	placenta
CoexpressionAtlas	dev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000	PCSK5 LAMB1 FRAS1 THBS1 FBN1 ADAM19 FBN2 ATRNL1	3.03e-05	777	35	8	gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_1000
CoexpressionAtlas	kidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_1000	PAPPA2 LAMB1 FRAS1 FBN1 FBN2 ZNF229 CHML SUSD1	3.20e-05	783	35	8	gudmap_kidney_P4_CapMesRenVes_Crym_1000
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#3_top-relative-expression-ranked_500	PAPPA2 FBN1 FBN2 ATRNL1	4.73e-05	122	35	4	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k3_500
CoexpressionAtlas	dev gonad_e12.5_F_VasAssMesen_MafB_k-means-cluster#4_top-relative-expression-ranked_500	PAPPA2 FBN1 FBN2 ATRNL1	9.51e-05	146	35	4	gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_k4_500
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000	PAPPA2 PCSK5 FBN1 FBN2 ATRNL1	1.46e-04	310	35	5	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k1_1000
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_1000	PAPPA2 PCSK5 LAMB1 FBN1 ADAM19 FBN2 ATRNL1	2.19e-04	768	35	7	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_1000
CoexpressionAtlas	dev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000	PAPPA2 LAMB1 PAPPA FBN1 ADAM19 FBN2 ATRNL1	2.27e-04	773	35	7	gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#3_top-relative-expression-ranked_500	THBS3 FBN2 ZNF229 EDIL3	2.51e-04	188	35	4	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_500_k3
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#3_top-relative-expression-ranked_1000	PAPPA2 FRAS1 FBN1 FBN2 ATRNL1	2.69e-04	354	35	5	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k3_1000
CoexpressionAtlas	dev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_1000	FRAS1 THBS1 FBN2 ATRNL1	3.12e-04	199	35	4	gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k1_1000
CoexpressionAtlas	DevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#4_top-relative-expression-ranked_500	THBS1 ZNF229 LONRF3	3.20e-04	81	35	3	gudmap_developingGonad_e18.5_ovary_500_k4
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500	PAPPA2 FBN1 FBN2 ATRNL1	3.62e-04	207	35	4	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k4_500
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_top-relative-expression-ranked_500	THBS3 FBN2 ZNF229 GPT2 EDIL3	4.10e-04	388	35	5	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_500
CoexpressionAtlas	kidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_500	PAPPA2 LAMB1 FRAS1 FBN2 CHML	4.61e-04	398	35	5	gudmap_kidney_P4_CapMesRenVes_Crym_500
CoexpressionAtlas	Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3	LAMB1 THBS1 FBN1	5.44e-04	97	35	3	GSM777043_100
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_top-relative-expression-ranked_500	PAPPA2 FBN1 ADAM19 FBN2 ATRNL1	5.76e-04	418	35	5	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#2_top-relative-expression-ranked_500	THBS1 FBN2 ATRNL1	5.95e-04	100	35	3	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k2_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#1_top-relative-expression-ranked_1000	PAPPA2 THBS1 FBN2 ATRNL1	6.33e-04	240	35	4	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k1_1000
CoexpressionAtlas	thyroid gland	SEC14L3 ESM1 FRAS1 FBN3	6.33e-04	240	35	4	thyroid gland
CoexpressionAtlas	Stromal Cells, Fi.Sk, gp38+ CD140a+, Skin, avg-4	LAMB1 TNS2 THBS1 THBS3 FBN1	7.04e-04	437	35	5	GSM777046_500
CoexpressionAtlas	Stromal Cells, Fi.MTS15+.Th, CD45- PDGFRa+ MTS15+, Thymus, avg-3	LAMB1 TNS2 THBS1 FBN1 ATRNL1	7.64e-04	445	35	5	GSM777043_500
CoexpressionAtlas	AravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_2500_k-means-cluster#2	PAPPA2 PAPPA CHAT FBN1 EDIL3 ATRNL1 FBN3	7.91e-04	951	35	7	Arv_EB-LF_2500_K2
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_1000	PAPPA FBN1 FBN2 ATRNL1	8.65e-04	261	35	4	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k4_1000
CoexpressionAtlas	dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k-means-cluster#3_top-relative-expression-ranked_500	THBS1 FBN2 ATRNL1	9.15e-04	116	35	3	gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_k3_500
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#2_top-relative-expression-ranked_1000	PAPPA2 FBN1 FBN2 ATRNL1	9.16e-04	265	35	4	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k2_1000
CoexpressionAtlas	Stromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5	LAMB1 TNS2 THBS1 FBN1 ATRNL1	9.39e-04	466	35	5	GSM777050_500
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMB1 TNS2 PAPPA FBN1 FBN2 EDIL3	5.42e-09	169	37	6	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PAPPA2 PCSK5 THBS1 FBN1 FBN2	4.36e-07	185	37	5	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 PAPPA THBS1 FBN1 FBN2	5.24e-07	192	37	5	ac1477433704573f95111eee6263b93668d2845e
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 PAPPA THBS1 FBN1 FBN2	5.24e-07	192	37	5	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 PAPPA THBS1 FBN1 FBN2	5.24e-07	192	37	5	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PCSK5 ESM1 TNS2 PAPPA FBN1	5.95e-07	197	37	5	b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	LAMB1 PAPPA THBS1 FBN1 EDIL3	5.95e-07	197	37	5	f1c8936986123a3151140c374fcd62d6705c530b
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 LAMB1 THBS1 FBN1 FBN2	5.95e-07	197	37	5	26475b9e4d6bfc0ae818dea13d139888ed7e92f1
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PCSK5 ESM1 TNS2 PAPPA FBN1	5.95e-07	197	37	5	5afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PCSK5 ESM1 TNS2 PAPPA FBN1	5.95e-07	197	37	5	1baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 LAMB1 THBS1 FBN1 FBN2	5.95e-07	197	37	5	155e63b33302a87393ace699b2f6d73abe9c5763
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 LAMB1 THBS1 FBN1 FBN2	6.10e-07	198	37	5	0993d6895c0e4f360998ce35abea4ec3dd13e048
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 LAMB1 THBS1 FBN1 FBN2	6.10e-07	198	37	5	a699b365d3b6149f13f02b2e2ae9b6fdce761848
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	LAMB1 PAPPA FRAS1 THBS1 FBN1	6.10e-07	198	37	5	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 LAMB1 THBS1 FBN1 FBN2	6.10e-07	198	37	5	a4005a49cf6709b543994ceb51ecd5dc46197fa9
ToppCell	10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LAMB1 TNS2 PAPPA FRAS1 FBN1	6.41e-07	200	37	5	ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	PCSK5 LAMB1 THBS1 FBN1 ATRNL1	6.41e-07	200	37	5	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	LAMB1 THBS1 FBN1 ADAM19	1.13e-05	168	37	4	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMB1 PAPPA FBN2 EDIL3	1.29e-05	174	37	4	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	normal_Lung-Fibroblasts-Mesothelial_cells\|normal_Lung / Location, Cell class and cell subclass	LAMB1 PAPPA FRAS1 ATRNL1	1.35e-05	176	37	4	f31d7234053085a82cf9d55aeedd1e04d34789c3
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPPA2 LAMB1 PAPPA FBN2	1.44e-05	179	37	4	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 PAPPA FBN1 EDIL3	1.48e-05	180	37	4	935c091bbcd6d10b81dc4731779e5bd98205c99f
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMB1 PAPPA FBN1 EDIL3	1.48e-05	180	37	4	f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCell	5'-Airway_Nasal-Mesenchymal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 PAPPA FBN1 EDIL3	1.48e-05	180	37	4	3dd384b7f3d9582b8fec9fe05100e466e6218b76
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LAMB1 PAPPA FBN1 ATRNL1	1.48e-05	180	37	4	01f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell	metastatic_Brain-Fibroblasts-Myofibroblasts\|metastatic_Brain / Location, Cell class and cell subclass	LAMB1 ESM1 FBN1 FBN2	1.51e-05	181	37	4	bd0b5f74f9c81ec0f1592710774a4fdf33d9d5a9
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNN2 PCSK5 ADAM19 FBN2	1.54e-05	182	37	4	52274af3136d4fd4a495f5882618444661421f0f
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNN2 PCSK5 ADAM19 FBN2	1.54e-05	182	37	4	dfde2d9950f445c6c936ac828f7210de87bb45ec
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 PAPPA FBN1 EDIL3	1.57e-05	183	37	4	6d98973098c6d20c5305bce6a83a549a7d8dbfba
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 PAPPA FBN1 EDIL3	1.57e-05	183	37	4	cc7f5a17b40e8d901885174922e5fa8877643071
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMB1 FBN2 EDIL3 ATRNL1	1.57e-05	183	37	4	8a799807fbf24456a9811e0c64068187940a2f71
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 PAPPA FBN1 EDIL3	1.57e-05	183	37	4	803376f5260de83c48d4f7301278d078a32b3e6e
ToppCell	(0)_MSCs-(00)_Lepr-MSC\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	LAMB1 ESM1 PAPPA FBN1	1.68e-05	186	37	4	f0d156167d7cc2cd8a76e5a364233e9f2170bc01
ToppCell	(0)_MSCs\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	LAMB1 ESM1 PAPPA FBN1	1.68e-05	186	37	4	a832c1e0035bcd559722eccf262c145deb3494c7
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 PAPPA FBN1 FBN2	1.71e-05	187	37	4	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 PAPPA FBN1 FBN2	1.71e-05	187	37	4	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 PAPPA FBN1 FBN2	1.71e-05	187	37	4	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PAPPA FRAS1 SUSD1 FBN3	1.75e-05	188	37	4	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPPA2 LAMB1 PAPPA FBN2	1.75e-05	188	37	4	997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell	RA-14._Fibroblast_III\|RA / Chamber and Cluster_Paper	PCSK5 PAPPA THBS1 FBN1	1.79e-05	189	37	4	46e9a58aacd79db5a02898a8c7244e1884adcfd1
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMB1 PAPPA THBS1 FBN1	1.79e-05	189	37	4	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PAPPA2 THBS1 THBS3 FBN1	1.86e-05	191	37	4	9bbafdf316c1fa3a9f1ee30d41dd7158b5c97279
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMB1 PAPPA THBS1 FBN1	1.86e-05	191	37	4	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	PCSK5 LAMB1 FRAS1 FBN1	1.86e-05	191	37	4	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB1 PAPPA FRAS1 SUSD1	1.86e-05	191	37	4	96b78b4e819ea6052334bfcbc7abbf35897df885
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	PCSK5 LAMB1 FRAS1 FBN1	1.86e-05	191	37	4	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMB1 PAPPA THBS1 FBN1	1.90e-05	192	37	4	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell	LPS-IL1RA-Stromal_mesenchymal\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMB1 PAPPA THBS1 FBN1	1.90e-05	192	37	4	4e47a02007f562f29ba5910df64d32a0167d0bd1
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMB1 PAPPA THBS1 FBN1	1.90e-05	192	37	4	ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB1 PAPPA FRAS1 SUSD1	1.90e-05	192	37	4	fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMB1 PAPPA THBS1 FBN1	1.90e-05	192	37	4	f4fc2b0121f879bab2bee99dfb5ff2c3ca1c0e1b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB1 PAPPA FRAS1 SUSD1	1.90e-05	192	37	4	bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCell	droplet-Fat-Mat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 LAMB1 PAPPA FBN1	1.94e-05	193	37	4	ebd090d7801480b3cee45caac3d30cc991836769
ToppCell	droplet-Fat-Mat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 LAMB1 PAPPA FBN1	1.94e-05	193	37	4	22c58032e58730715224d7934968ce92d150b0e8
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ESM1 TNS2 PAPPA FRAS1	1.94e-05	193	37	4	cf2461af78f65616ce40d552ee9452295e3895ed
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB1 THBS1 FBN1 ATRNL1	1.94e-05	193	37	4	5b602b1702283184bd3943c2a6f2290b7c37e407
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB1 THBS1 FBN1 ATRNL1	1.94e-05	193	37	4	c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB1 PAPPA THBS1 FBN1	1.94e-05	193	37	4	5bee7abc550ddaa28cbb3b9ecaf6b924ab175de0
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 THBS1 THBS3 FBN1	1.94e-05	193	37	4	160691b671710be10220803d788c2c961c236af1
ToppCell	droplet-Fat-Mat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 LAMB1 PAPPA FBN1	1.94e-05	193	37	4	573ad2f848bede1fe20c7b4b352a9242ec294725
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ESM1 TNS2 PAPPA FRAS1	1.94e-05	193	37	4	e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ESM1 TNS2 PAPPA FRAS1	1.94e-05	193	37	4	6ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCell	COVID-19-Heart-Fib_2\|Heart / Disease (COVID-19 only), tissue and cell type	LAMB1 PAPPA THBS1 FBN1	1.98e-05	194	37	4	d91c9f2ec47319051fc398320693fddbe8bbd4d6
ToppCell	droplet-Pancreas-Exocrine-21m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 LAMB1 FBN1 FBN2	1.98e-05	194	37	4	04ecb609d233a4b12e275c604810937830363e17
ToppCell	PCW_07-8.5\|World / Celltypes from embryonic and fetal-stage human lung	FBN2 EDIL3 ATRNL1 FBN3	1.98e-05	194	37	4	5759c83308df017f1faae248e9b85388e25254f0
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	LAMB1 PAPPA THBS1 FBN1	1.98e-05	194	37	4	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMB1 TNS2 THBS3 FBN1	1.98e-05	194	37	4	7b6ec45adb7ece3c8a7b78c5782413b5825effe2
ToppCell	droplet-Pancreas-Exocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 LAMB1 FBN1 FBN2	1.98e-05	194	37	4	775600880bb77781de48085d8744c1030223de1f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LAMB1 PAPPA THBS1 FBN1	1.98e-05	194	37	4	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	LA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	PCSK5 PAPPA THBS1 FBN1	1.98e-05	194	37	4	803fa83ceada17c38ca9f933b888f7e7b0b90761
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	PCSK5 LAMB1 PAPPA FBN1	1.98e-05	194	37	4	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	LV-14._Fibroblast_III\|LV / Chamber and Cluster_Paper	PCSK5 LAMB1 PAPPA THBS1	1.98e-05	194	37	4	927c26aea0147f7a4b8fb3f192de4de263f1b978
ToppCell	P15-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PAPPA2 PCSK5 THBS1 THBS3	1.98e-05	194	37	4	5f04d21c4e2d36e74b6c5889aa97fd98f75a0973
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 FBN1 ADAM19 ATRNL1	2.02e-05	195	37	4	dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 LAMB1 THBS3 FBN1	2.02e-05	195	37	4	69a29d03e664b72f32d41876510c62345c3aed31
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 THBS1 FBN1 FBN2	2.02e-05	195	37	4	2514c1f23424b5fc664d326d31ffd22bafe74ef8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	THBS1 FBN1 ADAM19 ATRNL1	2.02e-05	195	37	4	49c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCell	facs-GAT-Fat-3m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 LAMB1 THBS3 FBN1	2.02e-05	195	37	4	1cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCell	COVID-19-kidney-Fibroblast-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PAPPA THBS1 FBN1 ATRNL1	2.02e-05	195	37	4	3d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell	facs-Lung-3m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMB1 THBS1 THBS3 FBN1	2.02e-05	195	37	4	c4648c0332c3826776f9ad3f5f803dbac2b4c0c0
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 LAMB1 THBS3 FBN1	2.02e-05	195	37	4	9cef6f18664518060af7c192310dddce6d70345a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB1 THBS1 FBN1 ATRNL1	2.06e-05	196	37	4	3a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB1 THBS1 FBN1 ATRNL1	2.06e-05	196	37	4	bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCell	facs-Lung-nan\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 THBS1 THBS3 FBN1	2.06e-05	196	37	4	b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 THBS1 FBN1 FBN2	2.06e-05	196	37	4	e4d04e1f82779e8afd4e32bbe38d1d3f6f64ab50
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 THBS1 FBN1 FBN2	2.06e-05	196	37	4	f0fd7db22985d2bc84dc8bcbdb2d552e280121dd
ToppCell	facs-Lung-nan-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMB1 THBS1 THBS3 FBN1	2.06e-05	196	37	4	787c6cd92035e0b1108c2c086c42a229016e476b
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMB1 PAPPA FBN1 EDIL3	2.06e-05	196	37	4	2ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	LAMB1 PAPPA THBS1 FBN1	2.10e-05	197	37	4	fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell	10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LAMB1 TNS2 FBN1 EDIL3	2.10e-05	197	37	4	c165c6fd12dc649b39e920d8528e2eb65c61956b
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMB1 PAPPA THBS1 FBN1	2.10e-05	197	37	4	ab5d3ebc73bd7cfc64381d14b92878b370205186
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	LAMB1 PAPPA THBS1 FBN1	2.10e-05	197	37	4	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	10x3'2.3-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PCSK5 ESM1 PAPPA FBN1	2.14e-05	198	37	4	a8c21f4db6730d0aa05b61fbe72bf9f7571a9015
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 LAMB1 THBS1 FBN1	2.14e-05	198	37	4	b2d295e330772bd8e24da356c75564b4297ea9c5
ToppCell	10x3'2.3-week_14-16-Mesenchymal_adipo-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PCSK5 ESM1 PAPPA FBN1	2.14e-05	198	37	4	8b68fc887e5ad0a59ea4d93dfd1edda67030f142
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 LAMB1 THBS1 FBN1	2.14e-05	198	37	4	ce59ee3d970397eb62d6387699c6c6cd65457898
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMB1 TNS2 FBN1 EDIL3	2.14e-05	198	37	4	09be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCell	10x3'2.3-week_14-16-Mesenchymal_adipo\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PCSK5 ESM1 PAPPA FBN1	2.14e-05	198	37	4	4739b2e4ab141c66772e61686b45614a1839483e
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-D\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	CRELD2 CRELD1 PAPPA FBN1	2.14e-05	198	37	4	fd14efd8e6c74a04bde985c08dc34217c0ef1bab
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PAPPA2 LAMB1 THBS1 FBN1	2.14e-05	198	37	4	3ffaea4b44067d69f954b2bd3119c88a55ab232a
Computational	Neighborhood of EGFR	PAPPA2 PAPPA FBN2	4.08e-05	32	23	3	GNF2_EGFR
Computational	Neighborhood of TIMP2	PAPPA2 PAPPA FBN2	1.22e-04	46	23	3	GNF2_TIMP2
Computational	Neighborhood of KISS1	PAPPA2 PAPPA FBN2	1.48e-04	49	23	3	GNF2_KISS1
Drug	Rgd Peptide	LAMB1 FNDC3A THBS1 THBS3 FBN1 FBN2 EDIL3 FBN3	3.89e-09	239	37	8	CID000104802
Drug	Tubocurarine	KCNN2 CHAT POU5F1 EDIL3 ATRNL1	8.92e-08	69	37	5	ctd:D014403
Drug	pararosaniline base; Up 200; 10uM; MCF7; HT_HG-U133A_EA	CRELD1 ZNF134 THBS3 ZNF350 ATRNL1	9.56e-06	177	37	5	893_UP
Drug	2-[(1R,2R,3S,4R,5R,6S)-2-[(2R,5S)-3-[(3S,4S,5R,6S)-4,5-dihydroxy-3-(methylamino)-6-methylol-tetrahydropyran-2-yl]-4-formyl-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]oxy-5-guanidino-3,4,6-trihydroxy-cyclohexyl]guanidine	LAMB1 FNDC3A THBS1 FBN1	9.89e-06	83	37	4	CID011968896
Drug	Grgds	LAMB1 FNDC3A THBS1 POU5F1	9.89e-06	83	37	4	CID000123811
Drug	Nifuroxazide [965-52-6]; Down 200; 14.6uM; MCF7; HT_HG-U133A	LAMB1 TNS2 FNDC3A CHML TOP3A	1.38e-05	191	37	5	2850_DN
Drug	Amethopterin (R,S) [59-05-2]; Down 200; 8.8uM; PC3; HT_HG-U133A	ZNF134 THBS1 FBN1 EDIL3 TOP3A	1.53e-05	195	37	5	6654_DN
Drug	Tamoxifen citrate [54965-24-1]; Down 200; 7uM; MCF7; HT_HG-U133A	PAPPA2 KCNN2 TNS2 THBS1 TOP3A	1.60e-05	197	37	5	2212_DN
Drug	Clofazimine [2030-63-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A	PAPPA2 TNS2 FNDC3A THBS1 TOP3A	1.60e-05	197	37	5	3239_DN
Drug	Tenoxicam [59804-37-4]; Down 200; 11.8uM; MCF7; HT_HG-U133A	TNS2 FNDC3A THBS3 ZNF350 CHML	1.60e-05	197	37	5	2860_DN
Drug	Isoflupredone acetate [338-98-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A	LAMB1 CRELD1 TNS2 THBS1 THBS3	1.64e-05	198	37	5	5545_DN
Drug	Ketoprofen [22071-15-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A	PAPPA2 KCNN2 LAMB1 FNDC3A THBS1	1.64e-05	198	37	5	2316_DN
Drug	Meptazinol hydrochloride [59263-76-2]; Up 200; 14.8uM; MCF7; HT_HG-U133A	PAPPA2 KCNN2 CRELD1 FRAS1 CHML	1.68e-05	199	37	5	4774_UP
Drug	Picotamide monohydrate [80530-63-8]; Up 200; 10.2uM; MCF7; HT_HG-U133A	KCNN2 PAPPA CHAT ZNF350 FBN1	1.73e-05	200	37	5	6787_UP
Drug	galbacin	GPT2 TOP3A	3.84e-05	6	37	2	CID000234441
Drug	hyaluronan	LAMB1 FNDC3A FBN1 FBN2 GPT2	6.38e-05	263	37	5	CID000024759
Drug	funiferine N-oxide	FBN1 FBN2 TOP3A	6.91e-05	49	37	3	CID000191631
Drug	desmosine	FBN1 FBN2 FBN3	8.75e-05	53	37	3	CID000025435
Drug	MER-25	PAPPA CHAT	9.18e-05	9	37	2	CID000006222
Drug	borrelidin	GPT2 TARS1	1.40e-04	11	37	2	ctd:C005066
Drug	1xqc	FBN2 FBN3	1.40e-04	11	37	2	CID005287617
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A_EA	CRELD2 CRELD1 FNDC3A TOP3A	1.71e-04	172	37	4	1064_UP
Drug	trifluoperazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA	CRELD1 FNDC3A THBS3 ZNF350	1.71e-04	172	37	4	910_UP
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A	CRELD2 ZNF134 FNDC3A ZNF350	1.91e-04	177	37	4	1643_UP
Drug	icaritin	CHAT POU5F1	1.98e-04	13	37	2	ctd:C499403
Drug	5224221; Up 200; 12uM; MCF7; HT_HG-U133A_EA	CRELD1 THBS1 THBS3 ZNF350	1.99e-04	179	37	4	839_UP
Drug	1nmk	FNDC3A THBS1 POU5F1	2.09e-04	71	37	3	CID000447401
Drug	17-AAG; Up 200; 1uM; HL60; HT_HG-U133A	PCSK5 PAPPA THBS1 TOP3A	2.17e-04	183	37	4	6185_UP
Drug	Forskolin, from Coleus forskohlii; Up 200; 0.5uM; PC3; HT_HG-U133A	CRELD1 ZNF350 FBN1 EDIL3	2.17e-04	183	37	4	7059_UP
Drug	Tubocurarine,d	KCNN2 CHAT POU5F1	2.18e-04	72	37	3	CID000001210
Drug	NSC226080	PCSK5 FNDC3A THBS1 FBN1 FBN2 FBN3 TOP3A	2.30e-04	782	37	7	CID000005040
Drug	Fludrocortisone acetate [514-36-3]; Up 200; 9.4uM; HL60; HT_HG-U133A	TNS2 FBN1 CHML TOP3A	2.55e-04	191	37	4	2368_UP
Drug	Pindolol [13523-86-9]; Down 200; 16.2uM; PC3; HT_HG-U133A	FNDC3A THBS1 ZNF350 TOP3A	2.60e-04	192	37	4	4496_DN
Drug	Luteolin [491-70-3]; Up 200; 14uM; HL60; HT_HG-U133A	PAPPA2 THBS1 EDIL3 ATRNL1	2.60e-04	192	37	4	3041_UP
Drug	cis-4,7,10,13,16,19-Docosahexaenoic acid ethyl ester; Up 200; 100uM; MCF7; HT_HG-U133A_EA	CRELD1 THBS1 THBS3 ZNF350	2.66e-04	193	37	4	881_UP
Drug	2-propylpentanoic acid; Up 200; 50uM; HL60; HT_HG-U133A	PAPPA2 ESM1 THBS1 THBS3	2.66e-04	193	37	4	2682_UP
Drug	Leflunomide [75706-12-6]; Up 200; 14.8uM; MCF7; HT_HG-U133A	KCNN2 CRELD1 CHAT ZNF350	2.66e-04	193	37	4	7238_UP
Drug	Labetalol hydrochloride [32780-64-6]; Up 200; 11uM; MCF7; HT_HG-U133A	PAPPA2 KCNN2 CHAT FBN1	2.66e-04	193	37	4	6809_UP
Drug	Danazol [17230-88-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	FNDC3A THBS3 ZNF350 CHML	2.66e-04	193	37	4	5315_UP
Drug	AC1L1C6C	THBS1 POU5F1 FBN1	2.66e-04	77	37	3	CID000001759
Drug	Gut factor	CHAT FBN2	2.66e-04	15	37	2	CID000123786
Drug	3,5,6-trichloro-2-pyridinol	CHAT POU5F1	2.66e-04	15	37	2	ctd:C012587
Drug	CP-863187 [668981-07-5]; Down 200; 10uM; PC3; HT_HG-U133A	THBS1 FBN1 CHML EDIL3	2.71e-04	194	37	4	7558_DN
Drug	Hydrocortisone base [50-23-7]; Up 200; 11uM; MCF7; HT_HG-U133A	FRAS1 THBS1 ADAM19 ATRNL1	2.71e-04	194	37	4	3284_UP
Drug	Bepridil hydrochloride [74764-40-2]; Up 200; 10uM; HL60; HT_HG-U133A	PAPPA2 TNS2 FNDC3A CHML	2.71e-04	194	37	4	1274_UP
Drug	clofibrate; Up 200; 150uM; MCF7; HG-U133A	LAMB1 FNDC3A FRAS1 ATRNL1	2.71e-04	194	37	4	263_UP
Drug	Delcorine; Up 200; 8.4uM; MCF7; HT_HG-U133A	CHAT FRAS1 EDIL3 TOP3A	2.76e-04	195	37	4	3613_UP
Drug	Kawain [500-64-1]; Up 200; 17.4uM; MCF7; HT_HG-U133A	PAPPA2 THBS1 THBS3 ZNF350	2.82e-04	196	37	4	4693_UP
Drug	ST021200; Down 200; 10uM; PC3; HT_HG-U133A	THBS1 FBN1 CHML EDIL3	2.82e-04	196	37	4	7559_DN
Drug	Rolitetracycline [751-97-3]; Up 200; 7.6uM; HL60; HT_HG-U133A	SEC14L3 PAPPA CHML TOP3A	2.82e-04	196	37	4	3031_UP
Drug	3-nitropropionic acid; Down 200; 10uM; MCF7; HT_HG-U133A	PAPPA2 ZNF134 LONRF3 TOP3A	2.82e-04	196	37	4	6367_DN
Drug	rosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	PAPPA2 THBS1 ADAM19 LONRF3	2.82e-04	196	37	4	5593_UP
Drug	Sulfadimethoxine [122-11-2]; Up 200; 12.8uM; MCF7; HT_HG-U133A	KCNN2 THBS3 ZNF350 FBN1	2.82e-04	196	37	4	4724_UP
Drug	Flavoxate hydrochloride [3717-88-2]; Down 200; 9.4uM; HL60; HT_HG-U133A	PAPPA2 ZNF134 FNDC3A THBS1	2.82e-04	196	37	4	2373_DN
Drug	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	PAPPA2 LAMB1 THBS3 ZNF350	2.87e-04	197	37	4	7500_UP
Drug	Vitexin [3681-93-4]; Up 200; 9.2uM; MCF7; HT_HG-U133A	PAPPA2 PAPPA THBS1 EDIL3	2.87e-04	197	37	4	2810_UP
Drug	Ajmaline [4360-12-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A	LAMB1 TNS2 THBS3 ZNF350	2.87e-04	197	37	4	7484_UP
Drug	Chenodiol [474-25-9]; Down 200; 10.2uM; MCF7; HT_HG-U133A	CRELD1 ZNF350 CHML TOP3A	2.87e-04	197	37	4	6012_DN
Drug	3-Acetamidocoumarin [779-30-6]; Down 200; 19.6uM; MCF7; HT_HG-U133A	TNS2 ZNF134 THBS1 CHML	2.87e-04	197	37	4	7361_DN
Drug	Proxyphylline [603-00-9]; Down 200; 16.8uM; PC3; HT_HG-U133A	ESM1 TNS2 THBS3 CHML	2.87e-04	197	37	4	7290_DN
Drug	Cefixime [79350-37-1]; Down 200; 8.8uM; MCF7; HT_HG-U133A	PAPPA2 ZNF134 THBS1 CHML	2.87e-04	197	37	4	3247_DN
Drug	Carbinoxamine maleate salt [3505-38-2]; Up 200; 9.8uM; MCF7; HT_HG-U133A	PAPPA2 LAMB1 ZNF350 CHML	2.87e-04	197	37	4	3466_UP
Drug	Butylparaben [94-26-8]; Up 200; 20.6uM; HL60; HT_HG-U133A	PAPPA2 TNS2 PAPPA FBN1	2.87e-04	197	37	4	3069_UP
Drug	Mephentermine hemisulfate [1212-72-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A	TNS2 ZNF134 THBS3 ZNF350	2.87e-04	197	37	4	3425_DN
Drug	Saquinavir mesylate [149845-06-7]; Down 200; 5.2uM; PC3; HT_HG-U133A	THBS1 ZNF350 FBN2 TOP3A	2.87e-04	197	37	4	5770_DN
Drug	Delcorine; Up 200; 8.4uM; MCF7; HT_HG-U133A	CHAT FBN1 FBN2 TOP3A	2.87e-04	197	37	4	4737_UP
Drug	indomethacin, USP; Down 200; 100uM; SKMEL5; HG-U133A	FNDC3A FRAS1 THBS1 VPS33B	2.87e-04	197	37	4	503_DN
Drug	Beta-Escin [11072-93-8]; Down 200; 3.2uM; MCF7; HT_HG-U133A	PAPPA2 KCNN2 CRELD1 CHML	2.87e-04	197	37	4	6050_DN
Drug	Deltaline [6836-11-9]; Down 200; 7.8uM; MCF7; HT_HG-U133A	PAPPA2 FNDC3A ADAM19 LONRF3	2.87e-04	197	37	4	6026_DN
Drug	Dihydroergotamine tartrate [5989-77-5]; Down 200; 3uM; MCF7; HT_HG-U133A	LAMB1 CRELD1 THBS3 CHML	2.87e-04	197	37	4	2244_DN
Drug	Nystatine [1400-61-9]; Down 200; 4.4uM; HL60; HT_HG-U133A	PAPPA2 FBN1 FBN2 TOP3A	2.93e-04	198	37	4	2500_DN
Drug	AG-028671 [847803-03-6]; Down 200; 10uM; PC3; HT_HG-U133A	PAPPA2 THBS1 FBN1 TOP3A	2.93e-04	198	37	4	6557_DN
Drug	Sulfisoxazole [127-69-5]; Down 200; 15uM; MCF7; HT_HG-U133A	CRELD1 FNDC3A THBS1 ZNF350	2.93e-04	198	37	4	5622_DN
Drug	Procarbazine hydrochloride [366-70-1]; Up 200; 15.6uM; MCF7; HT_HG-U133A	KCNN2 PAPPA THBS3 LONRF3	2.93e-04	198	37	4	3533_UP
Drug	Tolbutamide [64-77-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A	CRELD1 TNS2 ZNF134 FNDC3A	2.93e-04	198	37	4	2320_DN
Drug	Ondansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A	PAPPA2 PAPPA FNDC3A ATRNL1	2.93e-04	198	37	4	3575_UP
Drug	Pantothenic acid calcium salt monohydrate [63409-48-3]; Up 200; 8uM; MCF7; HT_HG-U133A	KCNN2 PAPPA ZNF134 ADAM19	2.93e-04	198	37	4	3248_UP
Drug	Serotonin hydrochloride [153-98-0]; Down 200; 18.8uM; MCF7; HT_HG-U133A	LAMB1 ZNF134 THBS3 TOP3A	2.93e-04	198	37	4	3311_DN
Drug	Mephenytoin [50-12-4]; Up 200; 18.4uM; MCF7; HT_HG-U133A	LAMB1 TNS2 ZNF350 FBN2	2.93e-04	198	37	4	6275_UP
Drug	DO 897/99; Down 200; 8.2uM; MCF7; HT_HG-U133A	PAPPA2 CRELD1 TNS2 THBS1	2.93e-04	198	37	4	2877_DN
Drug	Isocarboxazid [59-63-2]; Down 200; 17.2uM; MCF7; HT_HG-U133A	LAMB1 TNS2 ZNF350 TOP3A	2.93e-04	198	37	4	3424_DN
Drug	Iohexol [66108-95-0]; Down 200; 4.8uM; MCF7; HT_HG-U133A	CRELD1 TNS2 LONRF3 CHML	2.93e-04	198	37	4	5704_DN
Drug	Glimepiride [93479-97-1]; Up 200; 8.2uM; MCF7; HT_HG-U133A	PAPPA THBS1 FBN1 EDIL3	2.98e-04	199	37	4	4973_UP
Drug	Lorglumide sodium salt [97964-56-2]; Up 200; 8.4uM; MCF7; HT_HG-U133A	PAPPA2 CRELD1 ZNF134 TOP3A	2.98e-04	199	37	4	6456_UP
Drug	Artemisinin [63968-64-9]; Down 200; 14.2uM; PC3; HT_HG-U133A	TNS2 THBS1 FBN1 CHML	2.98e-04	199	37	4	7247_DN
Drug	Lasalocid sodium salt [25999-20-6]; Down 200; 6.6uM; MCF7; HT_HG-U133A	KCNN2 LAMB1 CHML TOP3A	2.98e-04	199	37	4	3360_DN
Drug	Azlocillin sodium salt [37091-65-9]; Up 200; 8.2uM; MCF7; HT_HG-U133A	PAPPA2 CRELD1 THBS1 ADAM19	2.98e-04	199	37	4	6262_UP
Drug	Suloctidil [54063-56-8]; Down 200; 11.8uM; PC3; HT_HG-U133A	THBS1 THBS3 FBN2 EDIL3	2.98e-04	199	37	4	6675_DN
Drug	Butirosin disulfate salt [51022-98-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A	ESM1 CHAT THBS3 ATRNL1	2.98e-04	199	37	4	6080_UP
Drug	AC1NMIA2	THBS1 GPT2	4.32e-04	19	37	2	CID005051378
Drug	AGN-1133	THBS1 ADAM19 TOP3A	4.64e-04	93	37	3	CID000015178
Drug	2-methylindoline	PCSK5 CHAT	4.79e-04	20	37	2	CID000023305
Drug	delta-(l-alpha-aminoadipoyl)-l-cysteinyl-glycine	PAPPA2 PAPPA FNDC3A POU5F1	5.07e-04	229	37	4	CID004369448
Drug	chondroitin sulfate	PAPPA2 LAMB1 FNDC3A THBS1 THBS3	5.18e-04	413	37	5	CID000024766
Drug	TAAD	FBN1 FBN2	5.29e-04	21	37	2	CID000133445
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2 FBN3	1.67e-09	3	36	3	DOID:65 (implicated_via_orthology)
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	8.67e-06	4	36	2	DOID:0060249 (is_implicated_in)
Disease	parental longevity	SEC14L3 PCSK5 POU5F1 SUSD1 TOP3A	3.17e-04	494	36	5	EFO_0007796
Disease	FEV/FEC ratio	SEC14L3 PCSK5 CRELD1 FRAS1 THBS3 FBN1 ADAM19	6.15e-04	1228	36	7	EFO_0004713
Disease	Alzheimer disease, polygenic risk score	FRAS1 ZNF229 ZNF285 ZAN GPT2	6.88e-04	586	36	5	EFO_0030082, MONDO_0004975
Disease	primary dental caries	LNX2 SUSD1	7.92e-04	34	36	2	EFO_0600095
Disease	Endometrioma	LAMB1 PAPPA FBN1	9.97e-04	161	36	3	C0269102
Disease	Endometriosis	LAMB1 PAPPA FBN1	9.97e-04	161	36	3	C0014175
Disease	body surface area	PAPPA2 PCSK5 PAPPA FBN1 FBN2	1.04e-03	643	36	5	EFO_0022196
Disease	Familial thoracic aortic aneurysm and aortic dissection	FBN1 FBN2	1.92e-03	53	36	2	C4707243
Disease	interleukin 1 receptor antagonist measurement	PAPPA CHAT	1.92e-03	53	36	2	EFO_0004754

Protein segments in the cluster

Peptide	Gene	Start	Entry
KGYMGECGYRGGYME	GPT2	341	Q8TD30
MDGTPCEGGQAYCYN	ADAM19	501	Q9H013
YGFMGPQCERDYRTG	FBN3	171	Q75N90
PQGFCRMCAVFGGIY	CHML	386	P26374
GGYRCICAEGYKQME	CRELD1	326	Q96HD1
DGKCMSECPGGYYAD	FRAS1	586	Q86XX4
YGDMVPNTYCGKGVC	KCNN2	361	Q9H2S1
GTPAYYDGRLKCGDM	LNX2	636	Q8N448
CVRKCGPGFYGDQEM	PCSK5	1111	Q92824
MGHNCERCLAGYYGD	LAMB1	891	P07942
NGVCQYRCRYGKAPM	PLA2G12B	61	Q9BX93
KGCEPFMGDNYCDAI	PAPPA	1556	Q13219
PYEFCGGMAYCGPQV	POU5F1	66	Q01860
CVGEPSLCYMYEGDG	PAPPA2	1151	Q9BXP8
SLCYMYEGDGICEPF	PAPPA2	1156	Q9BXP8
PGEFMGRNCQYKCSG	EDIL3	146	O43854
NIPGEYRCLCYDGFM	FBN1	1256	P35555
LGSYKCMCPAGFQYE	FBN1	2626	P35555
GSMQICYCGPGLSYE	FNDC3A	801	Q9Y2H6
TGKQCQDCMPGYYGD	ATRNL1	1036	Q5VV63
FGICKDCPYGTFGMD	ESM1	96	Q9NQ30
NIPGEYRCLCYDGFM	FBN2	1301	P35556
CECPMGYNLDYTGVR	FBN2	2196	P35556
GYQGPLCTDCMDGYF	CRELD2	171	Q6UXH1
QKYMPGGLCGYDRDG	SEC14L3	81	Q9UDX4
MGEAMERVYGGCLCY	TARS1	161	P26639
MFCCYGPVVPNGYGA	CHAT	666	P28329
DPMYRCECKPGYAGN	THBS1	671	P07996
GSFECYCMDGYLPRN	SUSD1	146	Q6UWL2
GVDCMEVYEYPGYRC	THBS3	286	P49746
KNGGFYLSCMGFPEC	TOP3A	671	Q13472
DMPYRCDVCGKGFRY	ZNF229	346	Q9UJW7
PYGCNECGKAFAYMS	ZNF350	401	Q9GZX5
EMPYKCDECGKGFGF	ZNF285	341	Q96NJ3
EGCSYTMCPEGRYGH	TNS2	766	Q63HR2
PNCYGIGRCAKMAYE	VPS33B	191	Q9H267
GEMPYKCNECGKYFS	ZNF134	256	P52741
GERPYGCNECGKYFM	ZNF17	326	P17021
YYGKVCGMCGNFNDE	ZAN	2061	Q9Y493
MCLGDPVKGFAEYGC	LONRF3	596	Q496Y0