Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

TPCN2 RYR1 ITPR2 ITPR3

1.93e-06181034GO:0015278
GeneOntologyMolecularFunctionphosphatidylinositol binding

ANKFY1 TPCN2 INPPL1 KRIT1 IQGAP1 ITPR2 ITPR3 SNX25 GAB4 ZFYVE26

5.49e-0631610310GO:0035091
GeneOntologyMolecularFunctionkinase binding

MYH6 TPCN2 PDGFRB RBBP6 RAD54L2 IQGAP1 BICD1 MSN IBTK LATS1 PER2 TIAM1 GAB4 AKAP11 ZFYVE26 PLCB4 NOS2

8.92e-0696910317GO:0019900
GeneOntologyMolecularFunctionprotein kinase binding

MYH6 TPCN2 PDGFRB RBBP6 RAD54L2 IQGAP1 BICD1 MSN IBTK LATS1 TIAM1 GAB4 AKAP11 ZFYVE26 PLCB4 NOS2

9.86e-0687310316GO:0019901
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TPCN2 RYR1 ITPR2 ITPR3

1.89e-05311034GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

TPCN2 RYR1 ITPR2 ITPR3

2.44e-05331034GO:0005217
GeneOntologyMolecularFunctionphosphatidylinositol phosphate binding

ANKFY1 TPCN2 INPPL1 KRIT1 IQGAP1 GAB4 ZFYVE26

7.76e-051991037GO:1901981
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR2 ITPR3

7.88e-0531032GO:0005220
GeneOntologyMolecularFunctionphospholipid binding

ANKFY1 TPCN2 INPPL1 KRIT1 IQGAP1 ITPR2 ITPR3 TIAM1 SNX25 GAB4 ZFYVE26

1.23e-0454810311GO:0005543
GeneOntologyMolecularFunctioncytoskeletal protein binding

MYH2 MYH4 MYH6 INPPL1 STMN1 SYBU NEB TUBGCP5 KRIT1 IQGAP1 BICD1 MSN SETD2 TIAM1 FMN2 NOS2

1.55e-04109910316GO:0008092
GeneOntologyMolecularFunctioncalmodulin binding

MYH2 MYH4 MYH6 PDE1B RYR1 IQGAP1 NOS2

1.91e-042301037GO:0005516
GeneOntologyMolecularFunctionATPase inhibitor activity

TSC1 FNIP1

3.90e-0461032GO:0042030
GeneOntologyMolecularFunctionactin binding

MYH2 MYH4 MYH6 INPPL1 NEB IQGAP1 MSN FMN2 NOS2

8.34e-044791039GO:0003779
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH2 MYH4 MYH6

9.86e-04381033GO:0000146
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

TPCN2 HTR2C RYR1 ITPR2 ITPR3 IBTK PLCB4

8.66e-061461037GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

TPCN2 HTR2C RYR1 ITPR2 ITPR3 IBTK PLCB4

9.06e-061471037GO:0051283
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

TPCN2 HTR2C RYR1 ITPR2 ITPR3 IBTK PLCB4

9.89e-061491037GO:0051282
GeneOntologyBiologicalProcesssequestering of calcium ion

TPCN2 HTR2C RYR1 ITPR2 ITPR3 IBTK PLCB4

1.18e-051531037GO:0051208
GeneOntologyBiologicalProcessmuscle filament sliding

MYH2 MYH4 MYH6

5.27e-05151033GO:0030049
GeneOntologyBiologicalProcessactin-myosin filament sliding

MYH2 MYH4 MYH6

9.34e-05181033GO:0033275
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

TPCN2 HTR2C RYR1 ITPR2 ITPR3 IBTK PLCB4

1.09e-042171037GO:0097553
GeneOntologyCellularComponentmuscle myosin complex

MYH2 MYH4 MYH6

6.58e-05161053GO:0005859
GeneOntologyCellularComponentcentrosome

IFT57 RBBP6 ANKRD26 CCDC141 TUBGCP5 BICD1 LATS1 TIAM1 PARD6A KIAA1217 AKAP11 ZFYVE26 PLK4

1.28e-0477010513GO:0005813
GeneOntologyCellularComponentactin cytoskeleton

MYH2 MYH4 MYH6 FLT1 ANKRD26 TSC1 NEB IQGAP1 CENPQ FMN2 MYH16

1.52e-0457610511GO:0015629
GeneOntologyCellularComponentmicrotubule organizing center

IFT57 RBBP6 ANKRD26 CCDC141 TUBGCP5 BICD1 LATS1 TIAM1 PARD6A USO1 KIAA1217 AKAP11 ZFYVE26 PLK4

2.02e-0491910514GO:0005815
GeneOntologyCellularComponentmyosin complex

MYH2 MYH4 MYH6 MYH16

2.21e-04591054GO:0016459
GeneOntologyCellularComponentmyosin filament

MYH2 MYH4 MYH6

2.61e-04251053GO:0032982
GeneOntologyCellularComponentmyosin II complex

MYH2 MYH4 MYH6

3.68e-04281053GO:0016460
GeneOntologyCellularComponentcell cortex

MYH2 TSC1 RYR1 IQGAP1 ITPR2 PARD6A FMN2 NOS2

5.70e-043711058GO:0005938
GeneOntologyCellularComponentplatelet dense tubular network membrane

ITPR2 ITPR3

8.79e-0491052GO:0031095
GeneOntologyCellularComponentplatelet dense tubular network

ITPR2 ITPR3

1.33e-03111052GO:0031094
MousePhenoabnormal male preputial gland morphology

UACA EDA LEPR PER2

1.05e-0614824MP:0002717
MousePhenoabnormal glans penis morphology

UACA EDA LEPR PER2

1.90e-0616824MP:0009102
MousePhenoabnormal preputial gland morphology

UACA EDA LEPR PER2

1.90e-0616824MP:0013329
MousePhenoabnormal penis morphology

UACA EDA LEPR PER2

2.68e-0530824MP:0005187
MousePhenoabnormal sweat gland physiology

EDA ITPR2

3.40e-052822MP:0013368
MousePhenoabnormal sweat gland secretion

EDA ITPR2

3.40e-052822MP:0013369
MousePhenoincreased body size

HTR2C CYP19A1 ANKRD26 LEPR RYR1 ITPR3 PER2 USO1 KIAA1217 NOS2

1.34e-044098210MP:0001264
DomainMyosin-like_IQ_dom

MYH2 MYH4 MYH6 IQGAP1

2.93e-06191014IPR027401
Domain-

MYH2 MYH4 MYH6 IQGAP1

2.93e-061910144.10.270.10
DomainRIH_assoc

RYR1 ITPR2 ITPR3

3.03e-0661013PF08454
DomainRIH_assoc-dom

RYR1 ITPR2 ITPR3

3.03e-0661013IPR013662
DomainRIH_dom

RYR1 ITPR2 ITPR3

3.03e-0661013IPR000699
DomainIns145_P3_rcpt

RYR1 ITPR2 ITPR3

3.03e-0661013IPR014821
DomainRyanodine_recept-rel

RYR1 ITPR2 ITPR3

3.03e-0661013IPR015925
Domain-

RYR1 ITPR2 ITPR3

3.03e-06610131.25.10.30
DomainRYDR_ITPR

RYR1 ITPR2 ITPR3

3.03e-0661013PF01365
DomainIns145_P3_rec

RYR1 ITPR2 ITPR3

3.03e-0661013PF08709
DomainMIR

RYR1 ITPR2 ITPR3

1.79e-05101013PS50919
DomainMIR

RYR1 ITPR2 ITPR3

1.79e-05101013PF02815
DomainMIR

RYR1 ITPR2 ITPR3

1.79e-05101013SM00472
DomainMIR_motif

RYR1 ITPR2 ITPR3

1.79e-05101013IPR016093
DomainMyosin_N

MYH2 MYH4 MYH6

6.66e-05151013PF02736
DomainMyosin_N

MYH2 MYH4 MYH6

6.66e-05151013IPR004009
DomainInsP3_rcpt-bd

ITPR2 ITPR3

8.66e-0531012IPR000493
DomainMyosin_tail_1

MYH2 MYH4 MYH6

1.18e-04181013PF01576
DomainMyosin_tail

MYH2 MYH4 MYH6

1.18e-04181013IPR002928
DomainHIN_200

IFI16 PYHIN1

1.73e-0441012PS50834
DomainHIN

IFI16 PYHIN1

1.73e-0441012PF02760
DomainHIN200/IF120x

IFI16 PYHIN1

1.73e-0441012IPR004021
DomainAnk

ANKRD31 ANKFY1 UACA ANKRD26 KRIT1 IBTK ANKS1A

2.40e-042281017PF00023
DomainAWS

NSD1 SETD2

2.86e-0451012SM00570
DomainAWS

NSD1 SETD2

2.86e-0451012PS51215
DomainAWS_dom

NSD1 SETD2

2.86e-0451012IPR006560
Domain-

ANKRD31 ANKFY1 UACA ANKRD26 KRIT1 IBTK ANKS1A

3.98e-0424810171.25.40.20
DomainANK

ANKRD31 ANKFY1 UACA ANKRD26 KRIT1 IBTK ANKS1A

4.28e-042511017SM00248
DomainANK_REPEAT

ANKRD31 ANKFY1 UACA ANKRD26 KRIT1 IBTK ANKS1A

4.49e-042531017PS50088
DomainAnkyrin_rpt-contain_dom

ANKRD31 ANKFY1 UACA ANKRD26 KRIT1 IBTK ANKS1A

4.60e-042541017IPR020683
DomainANK_REP_REGION

ANKRD31 ANKFY1 UACA ANKRD26 KRIT1 IBTK ANKS1A

4.60e-042541017PS50297
DomainAnkyrin_rpt

ANKRD31 ANKFY1 UACA ANKRD26 KRIT1 IBTK ANKS1A

5.53e-042621017IPR002110
DomainIQ

MYH2 MYH4 MYH6 IQGAP1

5.93e-04711014PF00612
DomainTyr_kinase_rcpt_3_CS

FLT1 PDGFRB

7.94e-0481012IPR001824
DomainRECEPTOR_TYR_KIN_III

FLT1 PDGFRB

7.94e-0481012PS00240
DomainIQ

MYH2 MYH4 MYH6 IQGAP1

9.74e-04811014SM00015
DomainAnk_2

ANKRD31 ANKFY1 UACA ANKRD26 IBTK ANKS1A

1.11e-032151016PF12796
DomainMyosin_head_motor_dom

MYH2 MYH4 MYH6

1.13e-03381013IPR001609
DomainMYOSIN_MOTOR

MYH2 MYH4 MYH6

1.13e-03381013PS51456
DomainMyosin_head

MYH2 MYH4 MYH6

1.13e-03381013PF00063
DomainMYSc

MYH2 MYH4 MYH6

1.13e-03381013SM00242
DomainIQ_motif_EF-hand-BS

MYH2 MYH4 MYH6 IQGAP1

1.44e-03901014IPR000048
DomainIQ

MYH2 MYH4 MYH6 IQGAP1

1.63e-03931014PS50096
DomainPost-SET_dom

NSD1 SETD2

3.31e-03161012IPR003616
DomainPostSET

NSD1 SETD2

3.31e-03161012SM00508
DomainPOST_SET

NSD1 SETD2

3.31e-03161012PS50868
DomainIon_trans_dom

TPCN2 RYR1 ITPR2 ITPR3

3.41e-031141014IPR005821
DomainIon_trans

TPCN2 RYR1 ITPR2 ITPR3

3.41e-031141014PF00520
DomainRCC1

IBTK HERC6

5.16e-03201012PF00415
Domain-

ECT2L MSN TIAM1 GAB4 PLCB4 APBB1IP ANKS1A

5.33e-0339110172.30.29.30
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

HTR2C PDE1B PDGFRB RYR1 ITPR2 ITPR3 PLCB4 NOS2

7.38e-06178808M2890
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR2 ITPR3 PLCB4

2.05e-0510803M47661
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR2 ITPR3 PLCB4

2.81e-0511803M49033
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

ITPR2 ITPR3 PLCB4

4.83e-0513803M47656
PathwayREACTOME_PLATELET_HOMEOSTASIS

PDE1B ITPR2 ITPR3 GNB5 NOS2

6.99e-0576805MM15051
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

IQGAP1 ITPR2 ITPR3 GNB5

9.14e-0542804M791
PathwayREACTOME_PLATELET_HOMEOSTASIS

PDE1B ITPR2 ITPR3 GNB5 NOS2

1.26e-0486805M916
PathwayREACTOME_OPIOID_SIGNALLING

PDE1B ITPR2 ITPR3 GNB5 PLCB4

1.56e-0490805M6467
PathwayKEGG_GAP_JUNCTION

HTR2C PDGFRB ITPR2 ITPR3 PLCB4

1.56e-0490805M4013
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR1 ITPR2 ITPR3

1.60e-0419803M47760
PathwayKEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY

HTR2C ITPR2 ITPR3 PLCB4

1.82e-0450804M47951
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3 PLCB4

1.87e-0420803M47688
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3 PLCB4

2.17e-0421803M47689
PathwayWP_HIPPO_SIGNALING_REGULATION

FLT1 PDGFRB TEAD1 LATS1 PLCB4

2.33e-0498805M39830
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

PDE1B ITPR2 ITPR3 PLCB4

2.45e-0454804M26911
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3 PLCB4

2.51e-0422803M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3 PLCB4

2.51e-0422803M47675
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

FLT1 PDGFRB ITPR2 ITPR3

2.63e-0455804M47952
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

ITPR2 ITPR3 PLCB4

2.87e-0423803M47676
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR2 ITPR3

3.15e-045802M49000
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR2 ITPR3

4.70e-046802M47960
PathwayWP_HIPPOMERLIN_SIGNALING_DYSREGULATION

FLT1 PDGFRB TEAD1 LATS1 PLCB4

6.17e-04121805M39823
PathwayKEGG_LONG_TERM_DEPRESSION

RYR1 ITPR2 ITPR3 PLCB4

6.64e-0470804M8232
PathwayREACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION

ITPR2 ITPR3 GNB5

7.75e-0432803MM14983
PathwayWP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY

RYR1 ITPR2 ITPR3 NOS2

8.19e-0474804M48080
PathwayKEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM

INPPL1 ITPR2 ITPR3 PLCB4

9.05e-0476804M9052
PathwayREACTOME_RHO_GTPASE_CYCLE

ANKFY1 UACA RBBP6 ANKRD26 ARHGAP11A IQGAP1 TIAM1 PARD6A GOLGA3

9.89e-04450809M27078
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

IQGAP1 ITPR2 ITPR3 GNB5

9.98e-0478804M1921
PathwayKEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY

ITPR2 ITPR3

1.12e-039802M47852
PathwayWP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS

FLT1 PDGFRB TSC1 SETD2

1.44e-0386804M39375
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

EPRS1 STMN1 HNRNPH1 IQGAP1 MSN ITPR3 USO1 KIAA1217 ACAA2 GOLGA3

1.65e-073601061033111431
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DMXL2 ANKFY1 PDE1B CCT3 UACA NSD1 TSC1 SLC1A2 IQGAP1 MSN MDN1 KIAA1217 DZIP3 GOLGA3 ANKS1A

2.40e-079631061528671696
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

DMXL2 ANKFY1 UACA ANKRD26 ZNF407 TEAD1 NEB CCDC141 RYR1 MSN ACAA2

3.73e-074971061123414517
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

EPRS1 MYH4 CCT3 CCDC73 ZNF622 ZNF226 ARHGAP11A HNRNPH1 RYR1 ITPR2 MDN1 FMN2 DOP1B

4.02e-077361061329676528
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR1 ITPR2 ITPR3

5.47e-076106323463619
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR1 ITPR2 ITPR3

5.47e-076106325966694
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR1 ITPR2 ITPR3

5.47e-076106320519450
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR1 ITPR2 ITPR3

5.47e-076106316844763
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR1 ITPR2 ITPR3

9.55e-077106311860456
Pubmed

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.

LEPR ITPR2 ITPR3

9.55e-077106322495310
Pubmed

Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.

MYH2 MYH4 MYH6

9.55e-077106316819597
Pubmed

A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning.

MYH2 MYH4 MYH6

1.52e-068106314667415
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR1 ITPR2 ITPR3

1.52e-068106319033399
Pubmed

C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways.

ANKFY1 CCT3 HNRNPH1 GTF2I USO1 GOLGA3

1.82e-06119106635776542
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

INPPL1 ANKRD26 LATS1 MDN1 TIAM1 USO1 KIAA1217 FMN2 FNIP1 AKAP11 PLK4 DOP1B ANKS1A

2.29e-068611061336931259
Pubmed

Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.

MYH2 MYH4 MYH6 TEAD1

2.41e-0631106421985497
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

EPRS1 MYH4 CCT3 UACA IQGAP1 ITPR3 TIAM1

3.01e-06202106733005030
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

DMXL2 TSC1 BICD1 ITPR2 ITPR3 FMN2 FNIP1 AKAP11 GOLGA3 DOP1B

3.44e-065041061034432599
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

INPPL1 IBTK USO1 FNIP1 AKAP11 GOLGA3 ANKS1A

3.77e-06209106736779422
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

EPRS1 CCT3 RBBP6 ANKRD26 ZNF622 TSC1 STMN1 HNRNPH1 IBTK SETD2 GTF2I KIAA1217 ANKS1A

5.54e-069341061333916271
Pubmed

Network organization of the human autophagy system.

MYH2 MYH4 ANKFY1 CCT3 TSC1 IQGAP1 DZIP3 FNIP1 GOLGA3

8.06e-06437106920562859
Pubmed

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

ITPR2 ITPR3

9.20e-06210629065779
Pubmed

NSD1 Inactivation and SETD2 Mutation Drive a Convergence toward Loss of Function of H3K36 Writers in Clear Cell Renal Cell Carcinomas.

NSD1 SETD2

9.20e-062106228754676
Pubmed

Expression and prognostic value of NSD1 and SETD2 in pancreatic ductal adenocarcinoma and its precursor lesions.

NSD1 SETD2

9.20e-062106231060750
Pubmed

ER stress increases expression of intracellular calcium channel RyR1 to modify Ca2+ homeostasis in pancreatic beta cells.

LEPR RYR1

9.20e-062106237468098
Pubmed

Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

9.20e-06210628081734
Pubmed

The phenotype of vascular smooth muscle cells co-cultured with endothelial cells is modulated by PDGFR-β/IQGAP1 signaling in LPS-induced intravascular injury.

PDGFRB IQGAP1

9.20e-062106231523178
Pubmed

Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.

ITPR2 ITPR3

9.20e-062106215632133
Pubmed

Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex.

TSC1 SLC1A2

9.20e-062106220045054
Pubmed

Serotonin receptor 2C and insulin secretion.

HTR2C LEPR

9.20e-062106223349838
Pubmed

Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.

ITPR2 ITPR3

9.20e-062106217496801
Pubmed

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.

ITPR2 ITPR3

9.20e-062106224901844
Pubmed

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

ITPR2 ITPR3

9.20e-062106233854148
Pubmed

The Novel Pathogenesis of Retinopathy Mediated by Multiple RTK Signals is Uncovered in Newly Developed Mouse Model.

FLT1 PDGFRB

9.20e-062106229724654
Pubmed

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.

ITPR2 ITPR3

9.20e-062106219528657
Pubmed

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

ITPR2 ITPR3

9.20e-06210628063813
Pubmed

IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

ITPR2 ITPR3

9.20e-062106216195467
Pubmed

Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors.

RYR1 ITPR3

9.20e-062106221150295
Pubmed

Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling.

MYH2 MYH4

9.20e-062106221102503
Pubmed

Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.

ITPR2 ITPR3

9.20e-062106215713744
Pubmed

Combined vascular endothelial growth factor and platelet-derived growth factor inhibition in rat cardiac allografts: beneficial effects on inflammation and smooth muscle cell proliferation.

FLT1 PDGFRB

9.20e-062106215665766
Pubmed

Lethal multiple pterygium syndrome, large cystic hygroma, and cleft palate: Rare and severe fetal presentations of RYR1- and NEB-related congenital myopathies.

NEB RYR1

9.20e-062106238520674
Pubmed

Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation.

NSD1 SETD2

9.20e-062106218157086
Pubmed

Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy.

MYH2 MYH4 MYH6

9.77e-0614106324938781
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

ITPR2 ITPR3 PLCB4

1.22e-0515106328578927
Pubmed

A Large-scale genetic association study of esophageal adenocarcinoma risk.

FLT1 PDGFRB INPPL1 CYP19A1 TSC1 LEPR LATS1 NOS2

1.27e-05351106820453000
Pubmed

A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.

MYH2 MYH4 MYH6

1.50e-0516106319922871
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

EPRS1 UACA RBBP6 IFI16 HNRNPH1 IQGAP1 SETD2 LATS1 GTF2I MDN1 ANKS1A

2.52e-057741061115302935
Pubmed

Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.

MYH2 MYH4

2.76e-053106226059207
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR2 ITPR3

2.76e-053106210874040
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR2 ITPR3

2.76e-053106220395455
Pubmed

Association between LEP and LEPR gene polymorphisms and dyslipidemia in patients using atypical antipsychotic medication.

HTR2C LEPR

2.76e-053106220562674
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR2 ITPR3

2.76e-053106217437169
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR2 ITPR3

2.76e-053106218547250
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR2 ITPR3

2.76e-053106236350267
Pubmed

The versatility and universality of calcium signalling.

ITPR2 ITPR3

2.76e-053106211413485
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

2.76e-053106226009177
Pubmed

Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice.

HTR2C LEPR

2.76e-053106218477467
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR2 ITPR3

2.76e-05310621693919
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR2 ITPR3

2.76e-053106223955339
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR2 ITPR3

2.76e-053106231979185
Pubmed

YAP1/TEAD1 upregulate platelet-derived growth factor receptor beta to promote vascular smooth muscle cell proliferation and neointima formation.

PDGFRB TEAD1

2.76e-053106233753119
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR2 ITPR3

2.76e-053106224904548
Pubmed

ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression.

MYH2 MYH4

2.76e-053106223339872
Pubmed

Catalytically inactive SHIP2 inhibits proliferation by attenuating PDGF signaling in 3T3-L1 preadipocytes.

PDGFRB INPPL1

2.76e-053106218814181
Pubmed

The myosin alkali light chain proteins and their genes.

MYH2 MYH4

2.76e-05310623904738
Pubmed

Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation.

TSC1 FNIP1

2.76e-053106229897930
Pubmed

The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain.

INPPL1 LEPR

2.76e-053106220829391
Pubmed

Leptin, its receptor and aromatase expression in deep infiltrating endometriosis.

CYP19A1 LEPR

2.76e-053106226242176
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR2 ITPR3

2.76e-05310629858485
Pubmed

Intestinal mTOR regulates GLP-1 production in mouse L cells.

TSC1 LEPR

2.76e-053106226037201
Pubmed

Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.

ITPR2 ITPR3

2.76e-053106221435446
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR2 ITPR3

2.76e-05310629808793
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR2 ITPR3

2.76e-053106218194433
Pubmed

Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles.

MYH2 MYH4

2.76e-05310628145163
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR2 ITPR3

2.76e-053106227777977
Pubmed

Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.

INPPL1 ANKS1A

2.76e-053106229749928
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR2 ITPR3

2.76e-053106217581770
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR2 ITPR3

2.76e-053106218241669
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR2 ITPR3

2.76e-053106219068129
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

2.76e-053106217327232
Pubmed

Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.

HTR2C LEPR

2.76e-053106221835345
Pubmed

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.

TSC1 LEPR

2.76e-053106221606597
Pubmed

Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.

RYR1 ITPR2

2.76e-053106223223241
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR2 ITPR3

2.76e-053106216014380
Pubmed

Combined HTR2C-LEP and HTR2C-LEPR genotypes as a determinant for obesity in patients without antipsychotic drugs.

HTR2C LEPR

2.76e-053106224525657
Pubmed

A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle.

EDA LEPR

2.76e-053106229106399
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR2 ITPR3

2.76e-053106217890015
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR2 ITPR3

2.76e-053106223983250
Pubmed

Specific isomyosin proportions in hyperexcitable and physiologically denervated mouse muscle.

MYH2 MYH4

2.76e-053106215013776
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR2 ITPR3

2.76e-053106220427533
Pubmed

Tuberous sclerosis complex: disease modifiers and treatments.

HTR2C TSC1

2.76e-053106219005330
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

EPRS1 MYH2 MYH4 MYH6 CCT3 ZNF658 ANKRD26 TSC1 RAD54L2 NEB IQGAP1 MSN LATS1 MDN1 SNX25

3.21e-0514421061535575683
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

EPRS1 DMXL2 PDGFRB STMN1 RAD54L2 TUBGCP5 KRIT1 IQGAP1 BICD1 TIAM1 ZNF197 FMN2 GOLGA3 DOP1B

3.66e-0512851061435914814
Pubmed

A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.

MYH2 MYH4 MYH6

4.06e-0522106324301466
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

ITPR2 ITPR3 PLCB4

5.32e-0524106310843712
Pubmed

Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.

RYR1 ITPR3

5.50e-054106222100703
Pubmed

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.

ITPR2 ITPR3

5.50e-054106225215520
Pubmed

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.

ITPR2 ITPR3

5.50e-054106217925404
Pubmed

Centriole signaling restricts hepatocyte ploidy to maintain liver integrity.

ANKRD26 PLK4

5.50e-054106235981754
InteractionABTB2 interactions

MYH2 MYH4 MYH6 IFT57 NEB HNRNPH1 SETD2 TIAM1

4.47e-081011028int:ABTB2
InteractionCAMK2G interactions

TSC1 STMN1 NHLRC2 RYR1 IQGAP1 ITPR2 ITPR3 TIAM1 NOS2

3.63e-062401029int:CAMK2G
InteractionPFN1 interactions

ANKFY1 INPPL1 ANKRD26 TSC1 STMN1 NHLRC2 KIAA1217 FMN2 ACAA2 GOLGA3 APBB1IP DOP1B

1.02e-0550910212int:PFN1
InteractionFBXW11 interactions

EPRS1 SYBU IFI16 TUBGCP5 HNRNPH1 PYHIN1 GTF2I PER2 TIAM1 FNIP1 PLK4

2.76e-0547310211int:FBXW11
InteractionYWHAZ interactions

DMXL2 PDE1B UACA COL6A6 RNF8 ANKRD26 TSC1 NEB IFI16 MSN LATS1 PER2 TIAM1 PARD6A AKAP11 NOS2 PLK4 GOLGA3 ANKS1A

3.04e-05131910219int:YWHAZ
InteractionACTN4 interactions

EPRS1 MYH2 MYH6 ANKFY1 INPPL1 NEB HNRNPH1 IQGAP1 PER2 NOS2

3.56e-0540010210int:ACTN4
InteractionGJA1 interactions

MYH6 HTR2C UACA ANKRD26 ITPR2 ITPR3 GTF2I TIAM1 USO1 KIAA1217 PLK4 GOLGA3

3.87e-0558310212int:GJA1
InteractionIRAG1 interactions

ITPR2 ITPR3 GTF2I

4.40e-05141023int:IRAG1
InteractionRNF123 interactions

EPRS1 MYH4 CCT3 CCDC73 ZNF622 ZNF226 ARHGAP11A HNRNPH1 RYR1 ITPR2 MDN1 ATAD1 FMN2 DOP1B

6.88e-0582410214int:RNF123
InteractionHOMER3 interactions

IFT57 TSC1 NHLRC2 CCDC141 HNRNPH1 RYR1

7.86e-051401026int:HOMER3
InteractionHOMER1 interactions

IFT57 NHLRC2 RAD54L2 RYR1 CENPQ PLCB4

7.86e-051401026int:HOMER1
InteractionLRRC31 interactions

EPRS1 MYH4 CCT3 UACA IQGAP1 ITPR3 TIAM1

8.30e-052051027int:LRRC31
InteractionRASSF8 interactions

EDA BICD1 SETD2 LATS1 PARD6A

9.91e-05911025int:RASSF8
InteractionPGK1 interactions

COL6A6 INPPL1 STMN1 NHLRC2 CCDC7 PYHIN1 MSN PER2 ACAA2

1.03e-043671029int:PGK1
InteractionCIAO1 interactions

CCT3 RBBP6 TSC1 NEB HNRNPH1 CCDC7 ACAA2 GOLGA3

1.11e-042891028int:CIAO1
Cytoband3q13.13

IFT57 HHLA2 DZIP3

7.72e-061710533q13.13
GeneFamilyMyosin heavy chains

MYH2 MYH4 MYH6 MYH16

2.88e-07157141098
GeneFamilyAnkyrin repeat domain containing

ANKRD31 ANKFY1 UACA ANKRD26 KRIT1 IBTK ANKS1A

4.53e-05242717403
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR2 ITPR3

4.55e-053712297
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

IFI16 PYHIN1

1.51e-045712995
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

IFI16 PYHIN1

4.30e-0325712994
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

RYR1 ITPR3 DZIP3 AKAP11

5.60e-03181714694
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

ANKFY1 ZFYVE26

6.57e-033171281
GeneFamilyImmunoglobulin like domain containing

FLT1 PDGFRB CCDC141 LEPR

7.01e-03193714594
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

NSD1 SETD2

7.86e-0334712487
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

DMXL2 GALK2 TEAD1 ARHGAP11A KRIT1 BICD1 IBTK SETD2 MDN1 TIAM1 AKAP11 PLCB4 DOP1B ANKS1A

5.85e-0685610214M4500
CoexpressionAtlasdev gonad_e13.5_M_GermCell_Oct_k-means-cluster#4_top-relative-expression-ranked_1000

DMXL2 CCDC73 TSC1 DZIP3 AKAP11 STAG3

1.20e-05110986gudmap_dev gonad_e13.5_M_GermCell_Oct_k4_1000
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#1_top-relative-expression-ranked_500

DMXL2 CCDC73 SYBU DZIP3 TERB1 FNIP1

3.69e-05134986gudmap_developingGonad_e18.5_ovary_500_k1
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA ZNF366 LEPR BICD1 KIAA1217 PLCB4

3.83e-071931057e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA ZNF366 LEPR BICD1 KIAA1217 PLCB4

3.83e-0719310576e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLT1 UACA ZNF366 SYBU LEPR XAF1 PLCB4

3.83e-0719310572e72309607902dabe3218888b22a77fe941f3570
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_capillary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FLT1 UACA ZNF366 LEPR KIAA1217 XAF1 PLCB4

4.54e-0719810571d30a1f73b6d6d838f49751402a29c5ef54aa81f
ToppCellControl_saline|World / Treatment groups by lineage, cell group, cell type

UACA STMN1 LEPR GTF2I TIAM1 KIAA1217 PLCB4

4.70e-07199105711c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLT1 UACA ZNF366 IFI16 LEPR KIAA1217 PLCB4

4.86e-072001057a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellCOVID-19_Severe-NK_activated|COVID-19_Severe / Disease condition and Cell class

UACA PDGFRB IFI16 PYHIN1 MSN XAF1 HERC6

4.86e-072001057f1f6c7f7f75f891c9ccf6bf58f4d65b9cf10bbd8
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLT1 UACA ZNF366 IFI16 LEPR KIAA1217 PLCB4

4.86e-072001057b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLT1 ZNF366 XAF1 HERC6 NOS2 ANKS1A

3.04e-061691056987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCellControl|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STMN1 LEPR BICD1 GTF2I KIAA1217 PLCB4

3.97e-061771056b8ff6940e31b749776e81ae4f5bbd577dba9749c
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLT1 UACA EDA KIAA1217 PLCB4 NOS2

4.66e-061821056a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCellControl-Endothelial-Endothelial-Activated_Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UACA SYBU KIAA1217 XAF1 PLCB4 HERC6

4.81e-061831056e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IFT57 HNRNPH1 CFAP65 PER2 DZIP3 OSCP1

4.96e-0618410562df903924df9cb71039159416bcbe6a6614e21fe
ToppCellControl-Endothelial_cells-Endothelial_cells_(general)|Control / group, cell type (main and fine annotations)

FLT1 ZNF366 LEPR KIAA1217 PLCB4 ANKS1A

5.44e-061871056fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCellLPS-antiTNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA ZNF366 LEPR BICD1 PLCB4

5.61e-061881056789d1be574e693d7bdd488f3c72c6df788e47b47
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLT1 UACA ZNF366 LEPR XAF1 PLCB4

5.78e-0618910566463890d8dbee4bc198f91628a5f784970de786a
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLT1 UACA EDA KIAA1217 PLCB4 NOS2

6.14e-061911056f229abf69a1217194f74b0502486907e07dba989
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

UACA ZNF366 IFI16 LEPR XAF1 PLCB4

6.33e-06192105656b021c297a21dff357531f21e2464f85186106d
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA ZNF366 LEPR KIAA1217 PLCB4

6.52e-061931056af5108260783e69a7d67896c5bf64f862525926d
ToppCellControl-Endothelial-Endothelial-Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA LEPR BICD1 KIAA1217 PLCB4

6.52e-061931056e1d546165dcc2392f540162206852c4717d7306f
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLT1 UACA LEPR BICD1 KIAA1217 PLCB4

6.72e-06194105671ac69cdf7a08ca3ddfb5b492b14ac56b6cd5e5d
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA LEPR BICD1 KIAA1217 PLCB4

6.72e-0619410560b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLT1 UACA ZNF366 IFI16 LEPR PLCB4

6.92e-0619510566bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellnucseq-Endothelial-Endothelial_Vascular|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLT1 UACA LEPR KIAA1217 XAF1 PLCB4

7.12e-061961056686533fd3fba8e4df96b9dd1307e870e89db4332
ToppCellFetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLT1 UACA ZNF366 LEPR KIAA1217 PLCB4

7.33e-061971056b2b7f8dc8ca421441e4c99c4f5d18fbc1668d79f
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FLT1 UACA ZNF366 KIAA1217 XAF1 PLCB4

7.55e-061981056a1ccbf0e653b2dd665c2254920eb9b37243cc0bd
ToppCellSevere-B_intermediate-10|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

IFT57 NEB CCDC141 RYR1 PYHIN1 XAF1

7.55e-061981056dfae26c3513a82bb7cb8dadbfcea2a1f420b1bab
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FLT1 UACA IFI16 LEPR KIAA1217 PLCB4

7.99e-062001056dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

FLT1 UACA ZNF366 IFI16 LEPR KIAA1217

7.99e-062001056eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

FLT1 UACA IFI16 LEPR KIAA1217 PLCB4

7.99e-0620010563b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLT1 UACA ZNF366 IFI16 KIAA1217 PLCB4

7.99e-062001056a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

PDGFRB IFI16 PYHIN1 MSN XAF1 HERC6

7.99e-0620010562281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellLPS_anti-TNF-Endothelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLT1 UACA ZNF366 IFI16 KIAA1217 PLCB4

7.99e-0620010561d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCellLPS_IL1RA_TNF-Endothelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FLT1 UACA ZNF366 IFI16 KIAA1217 PLCB4

7.99e-062001056d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCellControl_saline-Endothelial-Endothelial-Activated_Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

UACA IFI16 MSN KIAA1217 XAF1 HERC6

7.99e-062001056be55cef682ba87250dad97689332c8820b3a7420
ToppCellLPS_anti-TNF-Endothelial-Endothelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FLT1 UACA ZNF366 IFI16 KIAA1217 PLCB4

7.99e-06200105660d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCellParenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NHLRC2 BICD1 KIAA1217 DZIP3 PLCB4 OSCP1

7.99e-062001056be46efc899d06c55ee297bee3126f69bcdb2048b
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell-Peri-Peri_Kcnj8|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDGFRB CCDC141 ITPR2 MSN VSTM4

3.33e-051551055ced64e26962c5c6e6d539f361fe57ab0b399e999
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDGFRB CCDC141 ITPR2 MSN VSTM4

3.33e-0515510550f24ef6486aef354f0911c06932cb01d1a0525ac
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell-Peri|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDGFRB CCDC141 ITPR2 MSN VSTM4

3.33e-051551055d8b5145258f075b15080f8739f537f48dd22225e
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FLT1 UACA ZNF366 CCDC141 MSN

4.36e-0516410556a41a159134e605b80d5e731f9ed5bc803bb531b
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell-Endo|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FLT1 UACA ZNF366 CCDC141 MSN

4.36e-051641055ec68954fc09b6850273b5e59caa6b09d02151097
ToppCellfrontal_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FLT1 UACA ZNF366 CCDC141 MSN

4.61e-05166105527af6c906cff1d40d134f0386db7708869691121
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLT1 CCT3 RNF8 NHLRC2 GNB5

4.88e-051681055c7021748003e5949f7caf7b3291c5bad294948c1
ToppCell368C-Lymphocytic-ILC|368C / Donor, Lineage, Cell class and subclass (all cells)

TPCN2 CCDC7 CENPQ MDN1 DOP1B

5.31e-0517110553b3143e4aa6520ee9c6b6f2482206ad3d8205d14
ToppCell368C-Lymphocytic-ILC-ILC-2|368C / Donor, Lineage, Cell class and subclass (all cells)

TPCN2 CCDC7 CENPQ MDN1 DOP1B

5.31e-051711055fd01076574dcc82bfd4a1538812500543b16794f
ToppCellSevere-B_intermediate-10|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

IFT57 NEB CCDC141 RYR1 XAF1

6.43e-051781055b7374a97c51239782bed658381a02cb1b3d9bf66
ToppCell368C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TPCN2 CCDC7 CENPQ MDN1 DOP1B

6.77e-051801055eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCellCiliated_cells-B-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

ECT2L CFAP65 FMN2 OSCP1 CCDC40

6.77e-051801055bdea5ec6b60fc8c7cce4d71db5da74ac8675e211
ToppCell368C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TPCN2 CCDC7 CENPQ MDN1 DOP1B

6.77e-051801055ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCelldroplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 UACA SYBU ITPR2 PLCB4

6.95e-05181105592d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCelldroplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 UACA SYBU ITPR2 PLCB4

7.14e-05182105581279877b920b5a1bc991a07d3031d6458700fe3
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4|TCGA-Thryoid / Sample_Type by Project: Shred V9

ANKFY1 IQGAP1 MSN ITPR3 DOP1B

7.51e-051841055d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

ECT2L CFAP65 HHLA2 FMN2 CCDC40

7.71e-05185105530f4980dee6cd5959655f8d74049f3bfb5312611
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 NSD1 SYBU ITPR2 PLCB4

7.91e-0518610550ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

EPRS1 DMXL2 ANKFY1 ITPR2 DOP1B

7.91e-0518610558571956890fc9894d766ba294a28e376b4aba428
ToppCellfacs-Heart-LV-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 UACA SYBU PLCB4 NOS2

8.32e-051881055ed11e26ff4ef3d6314b5f5734062519b9aa285c1
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

ECT2L CFAP65 HHLA2 FMN2 CCDC40

8.32e-05188105561a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLT1 LEPR BICD1 KIAA1217 PLCB4

8.32e-051881055117dc80fa940e6aa1b0187a43fdde33f3fcb578f
ToppCellfacs-Heart-LV-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 UACA SYBU PLCB4 NOS2

8.32e-051881055e5a8ca4613ab0bf1584b9e78959adf41d0bf379f
ToppCellfacs-Heart-LV-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 UACA SYBU PLCB4 NOS2

8.32e-0518810550fc3a6562e6895f6fe7a93397eae842a75c60c93
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ECT2L CFAP65 HHLA2 FMN2 CCDC40

8.53e-05189105568a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLT1 UACA EDA KIAA1217 XAF1

8.53e-051891055b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCellCF-Lymphoid-B_cell|CF / Disease state, Lineage and Cell class

IFT57 CCDC141 MDN1 SNX25 AKAP11

8.74e-051901055374d8fd63c733178acab07682ed1519693efab45
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLT1 UACA EDA KIAA1217 PLCB4

8.74e-0519010550e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLT1 ZNF366 SYBU LEPR XAF1

9.18e-051921055bacbaef1f230051335f4433e55db07a161b96b4c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLT1 ZNF366 IFI16 XAF1 PLCB4

9.18e-0519210551ee4783051ec94ea94600f040edcb385fc4289f1
ToppCellLPS-IL1RA+antiTNF-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA ZNF366 KIAA1217 PLCB4

9.18e-05192105504f5a2e3dd6beff027b89d66eefdd92036e041af
ToppCellEndothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|World / Lineage, Cell type, age group and donor

FLT1 UACA EDA KIAA1217 NOS2

9.18e-0519210551e156bab5ecf64627890d2de9b27603d9a01f28d
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCT3 PDGFRB STMN1 GTF2I ANKS1A

9.18e-05192105503dcd9405d3d76fc7455066ba5d83c09cd17072d
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA ZNF366 KIAA1217 PLCB4

9.18e-051921055c07d7b40b2aa4eb27ac85801c014a656e2fd01dc
ToppCellLPS-antiTNF-Endothelial-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA ZNF366 KIAA1217 PLCB4

9.41e-05193105502f633b016ab19bfa65bfd0cf32f000549a62148
ToppCellControl-Endothelial-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA LEPR KIAA1217 PLCB4

9.41e-051931055aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCellControl-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA LEPR KIAA1217 PLCB4

9.41e-051931055c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCellLPS-antiTNF-Endothelial|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA ZNF366 KIAA1217 PLCB4

9.41e-0519310555122b1ffba42de190061be34ecdc6176f84e56a3
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

IFI16 PYHIN1 DZIP3 XAF1 HERC6

9.41e-051931055fce4f805e53669acb4c188f87ac7d84408c0c218
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

IFI16 PYHIN1 DZIP3 XAF1 HERC6

9.41e-0519310556e1498153a7766c03fddbda1701dbf1596d21736
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DMXL2 CCDC141 EDA RYR1 APBB1IP

9.41e-051931055bd08555f02db8bc903caacae57e80bb91e2556ce
ToppCellPCW_13-14-Endothelial-Endothelial_immature-endo_immature4_(5)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FLT1 ZNF366 CCDC141 LEPR BICD1

9.41e-05193105501c71aa48875b5ad6c50cc810a72862e72f26ad0
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DMXL2 CCDC141 EDA RYR1 APBB1IP

9.41e-051931055374d0526a071e973c3f43b4564f78f6933bb67ed
ToppCellASK440-Epithelial-Ciliated|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

ECT2L CFAP65 DZIP3 OSCP1 CCDC40

9.41e-051931055a0baa8be6f590b2031fede22be588715ae458e93
ToppCellCF-Lymphoid|CF / Disease state, Lineage and Cell class

IFT57 PYHIN1 MDN1 SNX25 AKAP11

9.41e-05193105511de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

STMN1 ARHGAP11A PYHIN1 ACAA2 PLK4

9.64e-05194105517af04acd54dd6a895a966cbb4422de25dc4f1e6
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

STMN1 ARHGAP11A PYHIN1 ACAA2 PLK4

9.64e-0519410553c385d93c5fe1a7817813c492f79fdb94d887357
ToppCellnormal_Pleural_Fluid-T/NK_cells-Exhausted_CD8+_T|normal_Pleural_Fluid / Location, Cell class and cell subclass

PYHIN1 MSN DZIP3 ACAA2 APBB1IP

9.64e-05194105568a9e00c9e1a855eeebfc26c038652f3800758db
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLT1 UACA LEPR KIAA1217 PLCB4

9.64e-05194105568004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCellLPS_only-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA LEPR KIAA1217 PLCB4

9.64e-05194105558f069efdefa0366033764446b9d6ffd4a17807e
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic-lymphocyte|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

STMN1 ARHGAP11A PYHIN1 ACAA2 PLK4

9.64e-051941055635d0e88f9c542a1d9363066c6cdbc6e44db76c1
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 UACA LEPR KIAA1217 PLCB4

9.64e-051941055bfd92ec75facb0ba55c31e5f2e089d983b3d0169
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A6 NSD1 IQGAP1 FMN2 FNIP1

9.87e-0519510553e519cffa6144a62b06124642a14c9ff39b76554
ToppCellCOVID-19-Heart-EC_1|Heart / Disease (COVID-19 only), tissue and cell type

FLT1 UACA ZNF366 KIAA1217 XAF1

9.87e-05195105550a193475db1bb1e05b8590225a553688c372c14
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLT1 ZNF366 IFI16 XAF1 PLCB4

9.87e-05195105577e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ECT2L CFAP65 DZIP3 OSCP1 CCDC40

1.01e-04196105527b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCellCOVID-19-lung-Capillary_Aerocytes|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLT1 UACA ZNF366 KIAA1217 XAF1

1.01e-04196105549cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCellPCW_10-12-Endothelial-Endothelial_immature-endo_immature_venous_(4)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FLT1 ZNF366 CCDC141 LEPR BICD1

1.01e-04196105581278e696d823744267d6315c4d42799c4ea0b2c
ToppCellCOVID-19-lung-Capillary_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLT1 ZNF366 LEPR KIAA1217 XAF1

1.01e-041961055ac28e9be288af6f00a841aea4ce4b99aed6b4505
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

FLT1 UACA ZNF366 EDA KIAA1217

1.01e-0419610554ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCellEndothelial-capillary_endothelial_cell_(Cap1)|World / Lineage, Cell type, age group and donor

FLT1 UACA LEPR KIAA1217 PLCB4

1.01e-0419610550ce3ed27d2b9276390952652c17a8d6de13add36
ToppCellILEUM-inflamed-(7)_Endothelial_cell-(7)_CD36+_endothelial_cells|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FLT1 UACA PDGFRB IFI16 XAF1

1.04e-04197105566339b5aae3952f5c484c9dcb0cfb4fbd828d4cb
ToppCellCOPD-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

FLT1 IFI16 LEPR KIAA1217 ANKS1A

1.04e-04197105530dbc05ea66892d2e18ff375ffa86d1db7bc4083
DrugAC1L1CR9

RYR1 MSN ITPR3 PLCB4

2.14e-06211024CID000002023
Drug9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A

ANKFY1 SYBU RAD54L2 TUBGCP5 CEPT1 GTF2I PER2 GNB5

2.87e-0619610287552_UP
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH2 MYH4 MYH6

4.45e-06101003DOID:0111269 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH2 MYH4 MYH6

4.45e-06101003DOID:0111602 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH2 MYH4 MYH6

4.45e-06101003DOID:0111596 (implicated_via_orthology)
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH2 MYH4 MYH6

4.45e-06101003DOID:0110454 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH2 MYH4 MYH6

4.45e-06101003DOID:0080719 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH2 MYH4 MYH6

4.45e-06101003DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH2 MYH4 MYH6

4.45e-06101003DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH2 MYH4 MYH6

4.45e-06101003DOID:0080326 (implicated_via_orthology)
Diseasedistal myopathy (implicated_via_orthology)

MYH2 MYH4 MYH6

8.13e-06121003DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH2 MYH4 MYH6

8.13e-06121003DOID:2106 (implicated_via_orthology)
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH2 MYH4 MYH6

1.05e-05131003DOID:397 (implicated_via_orthology)
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH2 MYH4 MYH6

1.67e-05151003DOID:0050646 (implicated_via_orthology)
DiseaseSotos' syndrome

NSD1 SETD2

6.79e-0541002C0175695
DiseaseSarcomatoid Renal Cell Carcinoma

FLT1 TSC1 RYR1 SETD2 FMN2

7.69e-051281005C1266043
DiseaseChromophobe Renal Cell Carcinoma

FLT1 TSC1 RYR1 SETD2 FMN2

7.69e-051281005C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

FLT1 TSC1 RYR1 SETD2 FMN2

7.69e-051281005C1266044
DiseasePapillary Renal Cell Carcinoma

FLT1 TSC1 RYR1 SETD2 FMN2

7.69e-051281005C1306837
DiseaseRenal Cell Carcinoma

FLT1 TSC1 RYR1 SETD2 FMN2

7.69e-051281005C0007134
Diseasepreeclampsia, fetal genotype effect measurement

FLT1 ITPR2

1.13e-0451002EFO_0000668, EFO_0007959
Diseasesmoking cessation

IFT57 CCDC141 LEPR ITPR3 HHLA2 KIAA1217 ANKS1A

1.23e-043251007EFO_0004319
DiseaseConventional (Clear Cell) Renal Cell Carcinoma

FLT1 TSC1 RYR1 SETD2 FMN2

1.52e-041481005C0279702
DiseaseMULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE

NEB RYR1

1.69e-0461002C1854678
Diseaseretinal disease (implicated_via_orthology)

CEPT1 PLCB4

1.69e-0461002DOID:5679 (implicated_via_orthology)
DiseaseMental Depression

HTR2C PDE1B STMN1 SLC1A2 PER2 NOS2

2.33e-042541006C0011570
Diseaseneutrophil percentage of leukocytes

ZNF366 CYP19A1 IFI16 LEPR HNRNPH1 IQGAP1 VSTM4 SETD2 AKAP11

2.33e-046101009EFO_0007990
DiseaseLeydig cell tumor (is_marker_for)

FLT1 PDGFRB

3.14e-0481002DOID:2696 (is_marker_for)
DiseaseGestational Diabetes

CYP19A1 LEPR

4.03e-0491002C0085207
Diseaselymphocyte percentage of leukocytes

ZNF366 CYP19A1 IFI16 LEPR HNRNPH1 IQGAP1 VSTM4 SETD2 APBB1IP

4.37e-046651009EFO_0007993
DiseaseDepressive disorder

HTR2C PDE1B STMN1 SLC1A2 PER2 NOS2

4.62e-042891006C0011581
Diseasemyopathy (implicated_via_orthology)

MYH2 MYH4 MYH6

5.85e-04481003DOID:423 (implicated_via_orthology)
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR2 ITPR3

7.34e-04121002DOID:1441 (implicated_via_orthology)
Diseaseretinopathy of prematurity (biomarker_via_orthology)

FLT1 NOS2

7.34e-04121002DOID:13025 (biomarker_via_orthology)
DiseaseCongenital myopathy (disorder)

NEB RYR1

7.34e-04121002C0270960
Diseaseobesity (implicated_via_orthology)

ANKRD26 TSC1 LEPR ITPR2 ITPR3

8.42e-042151005DOID:9970 (implicated_via_orthology)
DiseaseKuhnt-Junius degeneration (is_marker_for)

FLT1 PDGFRB

1.01e-03141002DOID:10873 (is_marker_for)
DiseaseWithdrawal Symptoms

HTR2C PER2 NOS2

1.02e-03581003C0087169
DiseaseDrug Withdrawal Symptoms

HTR2C PER2 NOS2

1.02e-03581003C0086189
DiseaseSubstance Withdrawal Syndrome

HTR2C PER2 NOS2

1.02e-03581003C0038587
DiseaseHypogonadotropic hypogonadism

CYP19A1 LEPR

1.16e-03151002C0271623
DiseasePrimary hypogonadism

CYP19A1 LEPR

1.16e-03151002C0948896
DiseaseHypogonadism, Isolated Hypogonadotropic

CYP19A1 LEPR

1.16e-03151002C3489396
DiseaseHypogonadism

CYP19A1 LEPR

1.32e-03161002C0020619
Diseasecarcinoma (implicated_via_orthology)

FLT1 EDA LATS1

1.35e-03641003DOID:305 (implicated_via_orthology)
Diseaseautism spectrum disorder (implicated_via_orthology)

HTR2C PDGFRB TSC1 ITPR3

1.81e-031521004DOID:0060041 (implicated_via_orthology)
Diseasecardiomyopathy (implicated_via_orthology)

MYH2 MYH4 MYH6

1.83e-03711003DOID:0050700 (implicated_via_orthology)
DiseaseAutistic Disorder

CYP19A1 RNF8 NSD1 TSC1 NOS2

1.98e-032611005C0004352
DiseaseMammary Carcinoma, Human

FLT1 ZNF366 CYP19A1 STMN1 LEPR SETD2 NOS2

2.09e-035251007C4704874
DiseaseMammary Neoplasms, Human

FLT1 ZNF366 CYP19A1 STMN1 LEPR SETD2 NOS2

2.09e-035251007C1257931
DiseaseMammary Neoplasms

FLT1 ZNF366 CYP19A1 STMN1 LEPR SETD2 NOS2

2.14e-035271007C1458155
DiseaseMetabolic Syndrome X

HTR2C INPPL1

2.29e-03211002C0524620
Diseasecomplex trait

ANKRD31 DMXL2 CCDC141 LEPR ACAA2

2.33e-032711005EFO_0010578
DiseaseBreast Carcinoma

FLT1 ZNF366 CYP19A1 STMN1 LEPR SETD2 NOS2

2.40e-035381007C0678222
Diseaseneutrophil count

ZNF366 NSD1 NHLRC2 TEAD1 IFI16 LEPR ITPR2 SETD2 CEPT1 AKAP11 PLCB4 OSCP1

2.48e-03138210012EFO_0004833
Diseasehypothyroidism (biomarker_via_orthology)

MYH6 CYP19A1 NOS2

2.57e-03801003DOID:1459 (biomarker_via_orthology)
Diseasedilated cardiomyopathy (implicated_via_orthology)

MYH2 MYH4 MYH6

2.57e-03801003DOID:12930 (implicated_via_orthology)
Diseaseunipolar depression, neuroticism measurement

ZNF366 KIAA1217

2.99e-03241002EFO_0003761, EFO_0007660

Protein segments in the cluster

PeptideGeneStartEntry
MMTDLKQSHSVRLND

AKR1C8

1

Q5T2L2
DLDILHNSSQMKSMS

CENPQ

241

Q7L2Z9
AHMEKELQKMTSIAN

BICD1

481

Q96G01
LRHQDSMSKSEMQVK

CCDC7

756

Q96M83
MAVSMEKKLHNATNY

HTR2C

76

P28335
KVHMNDNSTKSLMVD

APBB1IP

181

Q7Z5R6
MATFRNNHMKTKASV

AKAP11

1

Q9UKA4
IDQMKQNITMKDHLS

ECT2L

751

Q008S8
SSRIKQFHMKSPQME

ERVV-2

486

B6SEH9
TQDACAKMRKSTEHM

ANKS1A

961

Q92625
IHKESDMIMAFSVNK

DMXL2

2656

Q8TDJ6
LNDEHKTMASRAKVM

RAD54L2

376

Q9Y4B4
MAQKKMNSENSHSHE

ANKRD26

891

Q9UPS8
GSIAKMLQHAASNKM

IQGAP1

1226

P46940
APLTHKMNKMVTSEQ

ERVK-21

21

P61571
DMHDSKTKEQRLMTA

NSD1

916

Q96L73
NENMAAKKKSVAMHT

GNB5

181

O14775
KNDEKMNEVMNLAHT

ITPR2

1226

Q14571
TEIQKSFHNLMMSDK

ITPR3

1766

Q14573
MNQTDTHIVEKMAKN

ANKRD31

1046

Q8N7Z5
KKHSADVMSEMAQIA

ANKFY1

336

Q9P2R3
SKALSSMHAKNVFTM

NOS2

721

P35228
TAMLSEHTSKLKMAE

MDN1

581

Q9NU22
DAAKAEHNMSKMSTE

LATS1

46

O95835
MEQNHSETMFKKAKT

IBTK

966

Q9P2D0
ASSMDTQMHSPKKQE

CFAP65

121

Q6ZU64
HEKTMFKDLMNMQSS

DOP1B

2001

Q9Y3R5
MMVRSSHQLSKQISD

KIAA1109

2911

Q2LD37
NNHKAKMNTGMEESE

PER2

1111

O15055
TSAHLERMKKNMEQT

MYH2

1781

Q9UKX2
MSCHFQQVKTMKTAL

PDE1B

336

Q01064
EMNKAATSHFNIRVM

GALK2

231

Q01415
TMKDGLHKMQSEHVS

HHLA2

226

Q9UM44
LQADSHIKMQMSEKK

HERC6

636

Q8IVU3
QKMHKEATSDMLQDT

ABCC11

731

Q96J66
MNHMSASLKISNSSK

OR56B1

1

Q8NGI3
QTCSTQTHKIMENKM

LEPR

1146

P48357
SMENKMSFIVHTKQA

KRIT1

701

O00522
SKKTANDMIHAENMR

MSN

536

P26038
TKENLMKMQSIAESH

TUBGCP5

621

Q96RT8
AVAAMSKDKANMQHR

HNRNPH1

341

P31943
DMQRSMLSKDNTVHD

GOLGA3

521

Q08378
MEKHNLESTMKTYVS

DZIP3

836

Q86Y13
TNNHQIKVMDLETKM

NHLRC2

551

Q8NBF2
SEEDKIKAMMSQSGH

RBBP6

126

Q7Z6E9
LSKNHMLSMAKCATQ

OR5AC1

86

P0C628
KTLDQVTDMMVANSH

PARD6A

226

Q9NPB6
AVKMVHADISINMSK

EDA

361

Q92838
TNKLVVAHMTKSEMH

CEPT1

331

Q9Y6K0
LKEKSNMTRNMHATV

IFT57

406

Q9NWB7
TSHELEAAAKTMMEK

CCDC141

511

Q6ZP82
IISKSSSMFHIMKHN

CYP19A1

96

P11511
LEKTQALQKTMHEQM

GAB4

546

Q2WGN9
SHMNKLKSAIEQAMK

FNIP1

361

Q8TF40
MTKTQSIYDDMKNHR

SLC1A2

516

P43004
TNMMTHLSKINGDIA

CCDC40

661

Q4G0X9
LLLKNSDKNVHSMSM

CCDC73

721

Q6ZRK6
SDKNVHSMSMLVKPN

CCDC73

726

Q6ZRK6
SKLMSEMHSFIQIQK

PYHIN1

386

Q6K0P9
APLTHKMNKMVTSEQ

ERVK-21

21

P61565
KKNQMSKLISEMHSF

IFI16

371

Q16666
KAAEMHKMKSTTQAN

GTF2I

86

P78347
HKMKSTTQANRMSVD

GTF2I

91

P78347
SSKEHMQPFKENMEQ

FMN2

1601

Q9NZ56
AHMMMKLAQDSSQIE

RYR1

3996

P21817
DLSMFSQNMTHIIKD

COL6A6

191

A6NMZ7
GLSHSQATMKVAVKM

PDGFRB

621

P09619
MKDSSCMKVHQDSAR

MROH5

36

Q6ZUA9
SQLTEKDSMIENMKS

USO1

751

O60763
TTIKCYSTQMKMEHE

ARHGAP11A

686

Q6P4F7
KTHMVVANTMEDFQK

EPRS1

1421

P07814
DKVNSMSIEEMATKN

TMC3

416

Q7Z5M5
MRAHQAKISMENSKA

PLCB4

1076

Q15147
KMQAQKEEVLSHMND

RNF8

381

O76064
EKHASQMISNKDEMG

SNX25

406

Q9H3E2
EKMMKTTANRNHTDS

KIAA1217

596

Q5T5P2
MKNKHSKQDEPDMIS

INPPL1

411

O15357
QEKAMKLHNASNSEM

SLC35B3

246

Q9H1N7
MAVAHALTEKSKAMT

CCT3

416

P49368
EQDTSAHLERMKKNM

MYH4

1776

Q9Y623
DTSAHLERMKKNMEQ

MYH6

1776

P13533
HASIMKLNQASMDKL

OSCP1

86

Q8WVF1
SVKQQNTMKYMTALH

PLK4

536

O00444
NNFSKMAEEKLTHKM

STMN1

91

P16949
KTHMENSMVELSKLQ

ANKRD20A12P

206

Q8NF67
RSSSDHEATAMMKAQ

ATAD1

201

Q8NBU5
MAMTAENLAVKHKIS

ACAA2

161

P42765
LQNKHSDTTKEVEMM

TSC1

866

Q92574
IMSKSFMVHQKLHTQ

ZNF197

716

O14709
FSVSTSLKKHMRMHN

ZNF791

561

Q3KP31
IKTMNKVASHINEMQ

TIAM1

1221

Q13009
MFKKMSNSEIIQHLT

STAG3

151

Q9UJ98
NKKLESLLQSMEMAH

SYBU

366

Q9NX95
MCQQSMQKSSLEFHK

XAF1

61

Q6GPH4
DSNSHSLKKDPMMCQ

TEX13C

436

A0A0J9YWL9
VMKISSNSFMNVHLE

SETD2

816

Q9BYW2
ASMETIQKSKMNAEA

MYH16

396

Q9H6N6
IHALTSENTNLKKMM

UACA

841

Q9BZF9
AEHEAKMSSLSQSMR

UACA

926

Q9BZF9
KTTAVEYNKVHMAMT

ZNF658

281

Q5TYW1
KDNMKILTFDHNSMI

ZNF226

231

Q9NYT6
KAFTQTSHLKRHMMQ

ZNF366

316

Q8N895
SSSLMKNVAHMTKDH

ZNF622

261

Q969S3
HSFDSQEALMVKMTK

VSTM4

66

Q8IW00
MKHLRTQMKTHDAES

ZNF407

461

Q9C0G0
DQTAKDKALQHMAAM

TEAD1

111

P28347
NNRTMHYSISKQKMA

FLT1

596

P17948
KMTAADVSRHMNTLQ

ZFYVE26

2321

Q68DK2
MFVKNLAKSSEHSMV

TERB1

61

Q8NA31
LDSSHKQAMMEKVRS

TPCN2

371

Q8NHX9
KLVHSMQVAKMQSDR

NEB

2086

P20929
LTDSMDMVLAKQNAH

NEB

2216

P20929