Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of skin epidermis

FLG KRT5 KRT6B KRT78 KRT6C

1.19e-0943235GO:0030280
GeneOntologyMolecularFunctionstructural molecule activity

FLG POM121L2 KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

3.13e-07891239GO:0005198
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

KRT5 KRT6B PLEC DSP

1.38e-05130234GO:0005200
GeneOntologyMolecularFunctionhelicase activity

DDX3Y POLQ DDX3X

7.66e-04158233GO:0004386
GeneOntologyMolecularFunctionDNA helicase activity

POLQ DDX3X

2.30e-0362232GO:0003678
GeneOntologyMolecularFunctionRNA helicase activity

DDX3Y DDX3X

3.61e-0378232GO:0003724
GeneOntologyMolecularFunctionATP-dependent activity, acting on RNA

DDX3Y DDX3X

3.80e-0380232GO:0008186
GeneOntologyMolecularFunctioncell adhesion molecule binding

PLEC DSP DDX3X EIF4G2

4.51e-03599234GO:0050839
GeneOntologyMolecularFunctionscaffold protein binding

KRT5 DSP

5.09e-0393232GO:0097110
GeneOntologyBiologicalProcessintermediate filament organization

DNAJB6 KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

1.46e-1475248GO:0045109
GeneOntologyBiologicalProcessintermediate filament cytoskeleton organization

DNAJB6 KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

1.46e-1399248GO:0045104
GeneOntologyBiologicalProcessintermediate filament-based process

DNAJB6 KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

1.58e-13100248GO:0045103
GeneOntologyBiologicalProcesskeratinocyte differentiation

FLG KRT5 KRT6B KRT78 PLEC KRT6C DSP

1.47e-09189247GO:0030216
GeneOntologyBiologicalProcessepidermal cell differentiation

FLG KRT5 KRT6B KRT78 PLEC KRT6C DSP

2.47e-08284247GO:0009913
GeneOntologyBiologicalProcessskin development

FLG KRT5 KRT6B KRT78 PLEC KRT6C DSP

1.59e-07373247GO:0043588
GeneOntologyBiologicalProcessepidermis development

FLG KRT5 KRT6B KRT78 PLEC KRT6C DSP

6.63e-07461247GO:0008544
GeneOntologyBiologicalProcesskeratinization

KRT5 KRT6B KRT78 KRT6C

2.94e-0687244GO:0031424
GeneOntologyBiologicalProcessepithelial cell differentiation

FLG KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

3.91e-06870248GO:0030855
GeneOntologyBiologicalProcesssupramolecular fiber organization

DNAJB6 KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

7.89e-06957248GO:0097435
GeneOntologyBiologicalProcessadherens junction organization

PLEC NUMBL DSP

4.77e-0561243GO:0034332
GeneOntologyBiologicalProcessepithelium development

FLG KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

1.70e-041469248GO:0060429
GeneOntologyBiologicalProcesspeptide cross-linking

FLG DSP

4.47e-0427242GO:0018149
GeneOntologyCellularComponentintermediate filament

KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

4.80e-09227247GO:0005882
GeneOntologyCellularComponentintermediate filament cytoskeleton

KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

1.33e-08263247GO:0045111
GeneOntologyCellularComponentcornified envelope

FLG KRT5 KRT78 DSP

1.10e-0669244GO:0001533
GeneOntologyCellularComponentkeratin filament

KRT5 KRT6B KRT78 KRT6C

4.31e-0697244GO:0045095
GeneOntologyCellularComponentsupramolecular fiber

DNAJB6 KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

3.26e-051179248GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

DNAJB6 KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

3.43e-051187248GO:0099081
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

4.84e-05899247GO:0099513
GeneOntologyCellularComponentpole plasm

DDX3Y DDX3X

5.03e-0429242GO:0045495
GeneOntologyCellularComponentgerm plasm

DDX3Y DDX3X

5.03e-0429242GO:0060293
GeneOntologyCellularComponentP granule

DDX3Y DDX3X

5.03e-0429242GO:0043186
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

FLG DDX3Y DDX3X

3.49e-03269243GO:0036464
GeneOntologyCellularComponentribonucleoprotein granule

FLG DDX3Y DDX3X

4.19e-03287243GO:0035770
HumanPhenoPalmoplantar blistering

KRT5 KRT6B PLEC

1.22e-0611113HP:0007446
HumanPhenoPalmoplantar keratoderma

KRT5 KRT6B PLEC KRT6C DSP

2.13e-06114115HP:0000982
HumanPhenoEpidermal thickening

POMC FLG KRT5 KRT6B PLEC KRT6C DSP

3.04e-06379117HP:0011368
HumanPhenoHyperkeratosis

FLG KRT5 KRT6B PLEC KRT6C DSP

3.27e-06233116HP:0000962
HumanPhenoPalmoplantar hyperkeratosis

KRT5 KRT6B PLEC KRT6C DSP

3.94e-06129115HP:0000972
HumanPhenoPalmar hyperkeratosis

KRT5 KRT6B PLEC KRT6C DSP

4.25e-06131115HP:0010765
HumanPhenoAbnormality of keratinization

FLG KRT5 KRT6B PLEC KRT6C DSP

4.29e-06244116HP:0001035
HumanPhenoPlantar hyperkeratosis

KRT5 KRT6B PLEC KRT6C DSP

4.42e-06132115HP:0007556
HumanPhenoThickened skin

POMC FLG KRT5 KRT6B PLEC KRT6C DSP

7.24e-06431117HP:0001072
HumanPhenoAbnormality of the plantar skin of foot

KRT5 KRT6B PLEC KRT6C DSP

1.58e-05171115HP:0100872
HumanPhenoBlistering by anatomical location

KRT5 KRT6B PLEC

1.90e-0526113HP:0033800
HumanPhenoSkin erosion

KRT5 PLEC DSP

2.38e-0528113HP:0200041
HumanPhenoStratum basale cleavage

KRT5 PLEC

2.54e-054112HP:0034193
HumanPhenoSkin fragility with non-scarring blistering

KRT5 PLEC

2.54e-054112HP:0007585
HumanPhenoOnychogryposis

KRT5 KRT6B PLEC

2.66e-0529113HP:0001805
HumanPhenoFragile skin

KRT5 PLEC DSP

5.59e-0537113HP:0001030
HumanPhenoIntra-epidermal blistering

KRT5 PLEC

6.33e-056112HP:0033802
HumanPhenoAplasia cutis congenita on trunk or limbs

KRT5 PLEC

6.33e-056112HP:0007589
HumanPhenoAbnormal blistering of the skin

KRT5 KRT6B PLEC DSP

7.20e-05115114HP:0008066
HumanPhenoAplasia cutis congenita

KRT5 PLEC DSP

7.64e-0541113HP:0001057
HumanPhenoOnychogryposis of toenails

KRT6B PLEC

8.85e-057112HP:0008401
HumanPhenoOnychogryposis

KRT6B PLEC

8.85e-057112HP:0001819
HumanPhenoAbnormal skin morphology of the palm

FLG KRT5 KRT6B PLEC KRT6C DSP

8.90e-05413116HP:0040211
HumanPhenoMitten deformity

KRT5 DSP

1.51e-049112HP:0004057
HumanPhenoAcral blistering

KRT5 PLEC

1.51e-049112HP:0031045
HumanPhenoAbnormal dermatological laboratory findings

KRT5 PLEC

1.89e-0410112HP:0003340
HumanPhenoLamina lucida cleavage

KRT5 PLEC

1.89e-0410112HP:0003341
HumanPhenoSubepidermal blistering

KRT5 PLEC

2.31e-0411112HP:0033804
HumanPhenoAbnormal dermoepidermal hemidesmosome morphology

PLEC DSP

2.31e-0411112HP:0032449
HumanPhenoNail dystrophy

KRT5 KRT6B PLEC DSP

2.36e-04156114HP:0008404
HumanPhenoAbnormal dermoepidermal junction morphology

PLEC DSP

2.77e-0412112HP:0031538
HumanPhenoBlistering by histological location

KRT5 PLEC

3.26e-0413112HP:0033801
HumanPhenoAbnormal palm morphology

FLG KRT5 KRT6B PLEC KRT6C DSP

3.28e-04521116HP:0100871
HumanPhenoOral mucosal blisters

KRT5 PLEC

3.80e-0414112HP:0200097
HumanPhenoRegional abnormality of skin

FLG KRT5 KRT6B PLEC KRT6C DSP

4.04e-04541116HP:0011356
HumanPhenoMilia

KRT5 PLEC

5.67e-0417112HP:0001056
HumanPhenoAbnormal oral mucosa morphology

KRT5 KRT6B PLEC KRT6C DSP

7.22e-04381115HP:0011830
HumanPhenoAbnormal epidermal morphology

FLG KRT6C DSP

9.02e-0494113HP:0011124
HumanPhenoAbnormal fingernail morphology

KRT5 KRT6B PLEC DSP

1.04e-03230114HP:0001231
HumanPhenoMuscle fiber splitting

DNAJB6 PLEC

1.05e-0323112HP:0003555
HumanPhenoHypopigmented macule

KRT5 PLEC

1.34e-0326112HP:0020073
HumanPhenoSkin vesicle

KRT5 PLEC

1.44e-0327112HP:0200037
HumanPhenoWhite lesion of the oral mucosa

KRT6B KRT6C

1.55e-0328112HP:0025125
HumanPhenoIncreased connective tissue

POMC PLEC

1.55e-0328112HP:0009025
HumanPhenoOral leukoplakia

KRT6B KRT6C

1.55e-0328112HP:0002745
HumanPhenoAlopecia

KRT5 KRT6B PLEC DSP

1.67e-03261114HP:0001596
HumanPhenoNail dysplasia

KRT5 KRT6B PLEC DSP

1.74e-03264114HP:0002164
HumanPhenoParakeratosis

KRT5 DSP

2.16e-0333112HP:0001036
HumanPhenoErythema

KRT5 PLEC DSP

2.46e-03133113HP:0010783
HumanPhenoAtrophic scars

KRT5 PLEC

2.71e-0337112HP:0001075
MousePhenodermal-epidermal separation

PLEC DSP

3.85e-059152MP:0011160
MousePhenoabnormal epidermal-dermal junction morphology

PLEC DSP

7.05e-0512152MP:0011159
MousePhenoabnormal epidermal layer morphology

KRT5 KRT6B PLEC DSP

1.59e-04271154MP:0001216
DomainIntermediate_filament_CS

KRT5 KRT6B KRT78 KRT24 KRT6C

1.19e-0863235IPR018039
DomainKeratin_2_head

KRT5 KRT6B KRT78 KRT6C

1.83e-0824234IPR032444
DomainKeratin_2_head

KRT5 KRT6B KRT78 KRT6C

1.83e-0824234PF16208
DomainFilament

KRT5 KRT6B KRT78 KRT24 KRT6C

2.19e-0871235SM01391
DomainIF

KRT5 KRT6B KRT78 KRT24 KRT6C

2.36e-0872235PS00226
DomainFilament

KRT5 KRT6B KRT78 KRT24 KRT6C

2.53e-0873235PF00038
DomainKeratin_II

KRT5 KRT6B KRT78 KRT6C

2.57e-0826234IPR003054
DomainIF

KRT5 KRT6B KRT78 KRT24 KRT6C

3.10e-0876235IPR001664
Domain-

PLEC DSP

2.17e-0562323.90.1290.10
DomainPlectin_repeat

PLEC DSP

3.03e-057232IPR001101
DomainPlectin

PLEC DSP

3.03e-057232PF00681
DomainPLEC

PLEC DSP

3.03e-057232SM00250
DomainDEAD/DEAH_box_helicase_dom

DDX3Y POLQ DDX3X

9.59e-0573233IPR011545
DomainDEAD

DDX3Y POLQ DDX3X

9.59e-0573233PF00270
DomainHelicase_C

DDX3Y POLQ DDX3X

2.98e-04107233PF00271
DomainHELICc

DDX3Y POLQ DDX3X

2.98e-04107233SM00490
DomainHelicase_C

DDX3Y POLQ DDX3X

3.06e-04108233IPR001650
DomainHELICASE_CTER

DDX3Y POLQ DDX3X

3.15e-04109233PS51194
DomainHELICASE_ATP_BIND_1

DDX3Y POLQ DDX3X

3.15e-04109233PS51192
DomainDEXDc

DDX3Y POLQ DDX3X

3.15e-04109233SM00487
DomainHelicase_ATP-bd

DDX3Y POLQ DDX3X

3.23e-04110233IPR014001
DomainSpectrin_repeat

PLEC DSP

5.77e-0429232IPR002017
DomainDEAD_ATP_HELICASE

DDX3Y DDX3X

6.60e-0431232PS00039
DomainSpectrin/alpha-actinin

PLEC DSP

7.04e-0432232IPR018159
DomainSPEC

PLEC DSP

7.04e-0432232SM00150
DomainRNA-helicase_DEAD-box_CS

DDX3Y DDX3X

7.48e-0433232IPR000629
DomainRNA_helicase_DEAD_Q_motif

DDX3Y DDX3X

9.41e-0437232IPR014014
DomainQ_MOTIF

DDX3Y DDX3X

9.41e-0437232PS51195
DomainPrefoldin

KRT24 DSP

3.52e-0372232IPR009053
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

FLG KRT5 KRT6B KRT78 KRT24 KRT6C DSP

4.77e-10129217M27649
PathwayREACTOME_KERATINIZATION

FLG KRT5 KRT6B KRT78 KRT24 KRT6C DSP

1.80e-08217217M27640
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT5 KRT6B KRT78 KRT24 DSP

1.50e-0787215MM15351
PathwayREACTOME_DIFFERENTIATION_OF_KERATINOCYTES_IN_INTERFOLLICULAR_EPIDERMIS_IN_MAMMALIAN_SKIN

FLG KRT5 KRT78 KRT24

3.21e-0740214M48231
PathwayREACTOME_KERATINIZATION

KRT5 KRT6B KRT78 KRT24 DSP

2.49e-06153215MM15343
PathwayREACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY

KRT5 PLEC

7.56e-059212MM15117
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

POMC FLG KRT5 KRT6B CNOT11 KRT78 KRT24 KRT6C DSP

1.06e-041432219M509
PathwayREACTOME_TYPE_I_HEMIDESMOSOME_ASSEMBLY

KRT5 PLEC

1.15e-0411212M27372
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

KRT5 KRT6B KRT78 KRT24 DSP

7.11e-04502215MM14537
PathwayREACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS

PLEC DSP

1.36e-0337212MM14488
PathwayREACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS

PLEC DSP

1.44e-0338212M495
PathwayREACTOME_APOPTOTIC_EXECUTION_PHASE

PLEC DSP

2.38e-0349212MM15448
PathwayREACTOME_APOPTOTIC_EXECUTION_PHASE

PLEC DSP

2.68e-0352212M2341
PathwayWP_NOVEL_INTRACELLULAR_COMPONENTS_OF_RIGILIKE_RECEPTOR_PATHWAY

DDX3Y DDX3X

3.55e-0360212M39583
Pubmed

Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.

FLG KRT5 DDX3Y KRT6B KRT78 KRT24 PLEC KRT6C DSP DDX3X

7.31e-13488251031324722
Pubmed

TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.

FLG KRT5 KRT6B KRT78 DSP DDX3X

4.62e-119125634445801
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

RBM15B FLG KRT5 KRT6B KRT78 KRT6C DSP DDX3X EIF4G2

2.19e-1060525928977666
Pubmed

New consensus nomenclature for mammalian keratins.

KRT5 KRT6B KRT78 KRT24 KRT6C

8.57e-106325516831889
Pubmed

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

DNAJB6 FLG KRT5 KRT6B KRT78 PLEC DSP DDX3X

3.55e-0955825827591049
Pubmed

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

FLG KRT5 KRT6B KRT78 KRT6C DSP DDX3X

3.74e-0934625725324306
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

FLG KRT5 KRT6B KRT78 KRT6C DSP DDX3X EIF4G2

1.05e-0864125836057605
Pubmed

Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA.

KRT5 KRT6B KRT78 KRT6C DSP

1.27e-0810725532989256
Pubmed

Charting the molecular network of the drug target Bcr-Abl.

KRT5 KRT6B KRT78 KRT24 KRT6C DDX3X

2.97e-0826625619380743
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

RBM15B FLG KRT5 DDX3Y KRT78 PLEC NUMBL DSP DDX3X

3.44e-08108225938697112
Pubmed

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.

KRT5 PLEC DSP

5.39e-081125312802069
Pubmed

EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.

KRT5 KRT6B KRT78 PLEC

6.41e-085425435474131
Pubmed

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.

FLG KRT5 KRT78 PLEC KRT6C DSP

7.62e-0831225637120454
Pubmed

RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.

KRT5 KRT6B KRT78 KRT6C

7.99e-085725431862882
Pubmed

Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.

DDX3Y KRT6B KRT6C DDX3X

2.44e-077525431527668
Pubmed

Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.

KRT5 KRT6B KRT6C DSP DDX3X

2.69e-0719725523686814
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

DNAJB6 KRT5 DDX3Y KRT6B KRT78 PLEC NUMBL DSP EIF4G2

3.71e-07143125937142655
Pubmed

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

KRT5 KRT6B KRT78 DSP

3.85e-078425429563501
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

DNAJB6 FLG KRT5 KRT6B PLEC POLQ KRT6C DSP PHTF1

3.95e-07144225935575683
Pubmed

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

KRT5 KRT6B KRT78 PLEC DSP DDX3X

4.19e-0741725619199708
Pubmed

A functional reference map of the RNF8 interactome in cancer.

FLG KRT5 KRT6B KRT78 DSP

4.43e-0721825535831895
Pubmed

Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.

DDX3Y DDX3X

4.96e-07225234437837
Pubmed

Characterization of D1Pas1, a mouse autosomal homologue of the human AZFa region DBY, as a nuclear protein in spermatogenic cells.

DDX3Y DDX3X

4.96e-07225211591417
Pubmed

Structural characterization and expression studies of Dby and its homologs in the mouse.

DDX3Y DDX3X

4.96e-07225216728723
Pubmed

An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility.

DDX3Y DDX3X

4.96e-07225230613052
Pubmed

Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation.

DDX3Y DDX3X

4.96e-07225235588748
Pubmed

Gene structure of the human DDX3 and chromosome mapping of its related sequences.

DDX3Y DDX3X

4.96e-07225211710523
Pubmed

The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.

FLG KRT6B KRT78 DSP

7.77e-0710025421800051
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

FLG KRT5 KRT6B DSP DDX3X

7.89e-0724525535652658
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

KRT5 DDX3Y KRT6B KRT24 POLQ KRT6C DSP DDX3X

9.32e-07115325829845934
Pubmed

EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.

KRT5 DDX3Y KRT6B PLEC KRT6C DSP DDX3X

1.14e-0680325736517590
Pubmed

Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.

KRT6B KRT6C

1.49e-06325229357356
Pubmed

Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins.

KRT5 DSP

1.49e-0632527525601
Pubmed

Cytokeratin 5/6 expression in bladder cancer: association with clinicopathologic parameters and prognosis.

KRT5 KRT6B

1.49e-06325229587848
Pubmed

Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.

KRT6B KRT6C

1.49e-0632527543104
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

KRT5 DDX3Y KRT6B PLEC DSP DDX3X EIF4G2

1.59e-0684425725963833
Pubmed

Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR.

KRT5 KRT78 KRT24 DSP DDX3X

1.77e-0628925537132043
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

DNAJB6 RBM15B KRT5 KRT6B KRT78 PLEC DSP DDX3X

1.78e-06125725836526897
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

KRT5 KRT6B KRT78 DDX3X EIF4G2

2.06e-0629825530737378
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

KRT5 KRT6B KRT78 PLEC KRT6C DSP

2.41e-0656425621565611
Pubmed

E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis.

KRT5 KRT78 KRT6C DSP

2.58e-0613525429859926
Pubmed

LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.

KRT5 KRT6B KRT24 PLEC DSP DDX3X

2.83e-0658025635676659
Pubmed

Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.

KRT6B DSP

2.97e-06425230389720
Pubmed

The Mrj co-chaperone mediates keratin turnover and prevents the formation of toxic inclusion bodies in trophoblast cells of the placenta.

DNAJB6 DSP

2.97e-06425217409114
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

KRT5 KRT6B CNOT11 PLEC KRT6C DSP DDX3X EIF4G2

4.28e-06141525828515276
Pubmed

Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12.

KRT5 KRT6B

4.95e-0652521713141
Pubmed

Airway hillocks are injury-resistant reservoirs of unique plastic stem cells.

KRT5 KRT6B

4.95e-06525238693267
Pubmed

The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.

KRT5 KRT6B

4.95e-06525223075894
Pubmed

Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals.

DDX3Y DDX3X

4.95e-0652528144024
Pubmed

Role for keratins 6 and 17 during wound closure in embryonic mouse skin.

KRT5 KRT6B

4.95e-06525212557214
Pubmed

Pachyonychia Congenita

KRT6B KRT6C

4.95e-06525220301457
Pubmed

p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.

KRT5 KRT6B

7.43e-06625225383540
Pubmed

Keratin 6 is not essential for mammary gland development.

KRT5 KRT6B

7.43e-06625216790075
Pubmed

Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse.

KRT5 KRT6B

7.43e-06625216239341
Pubmed

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.

FLG PLEC DSP

8.87e-065625337059927
Pubmed

Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel.

KRT5 KRT6B

1.04e-05725219720911
Pubmed

Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18.

KRT78 KRT6C

1.04e-05725211683385
Pubmed

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.

DNAJB6 KRT5 PLEC DSP DDX3X

1.07e-0541825532552912
Pubmed

Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.

KRT5 KRT6B DSP

1.09e-056025331220272
Pubmed

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

KRT5 KRT78 DSP

1.21e-056225326644517
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

KRT5 KRT78 PLEC DSP

1.27e-0520225433005030
Pubmed

Epidermolysis Bullosa Simplex

KRT5 PLEC

1.39e-05825220301543
Pubmed

Plakin proteins are coordinately cleaved during apoptosis but preferentially through the action of different caspases.

PLEC DSP

1.78e-05925215500642
Pubmed

Type II keratins precede type I keratins during early embryonic development.

KRT5 KRT6B

1.78e-05925216180309
Pubmed

Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.

PLEC DSP

1.78e-05925212482924
Pubmed

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.

KRT5 KRT78 PLEC KRT6C

1.84e-0522225435941108
Pubmed

CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway.

FLG PLEC DSP

1.89e-057225336123327
Pubmed

TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.

DDX3Y DDX3X

2.22e-051025218632687
Pubmed

Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.

KRT5 DSP

2.22e-051025210852826
Pubmed

TRIM58 inactivates p53/p21 to promote chemoresistance via ubiquitination of DDX3 in breast cancer.

KRT5 DDX3X

2.22e-051025234954155
Pubmed

Interaction of plectin with keratins 5 and 14: dependence on several plectin domains and keratin quaternary structure.

KRT5 PLEC

2.22e-051025224940650
Pubmed

DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.

FLG KRT5 KRT78 DSP

2.42e-0523825435864588
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

RBM15B KRT5 KRT6B PLEC POLQ

2.43e-0549625531343991
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

DNAJB6 KRT5 PLEC DSP DDX3X EIF4G2

2.54e-0585325628718761
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DNAJB6 KRT78 PLEC NUMBL DSP DDX3X

2.68e-0586125636931259
Pubmed

Current insights into the formation and breakdown of hemidesmosomes.

KRT5 PLEC

2.72e-051125216757171
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

PLEC DSP DDX3X EIF4G2

3.21e-0525625433397691
Pubmed

Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA.

KRT5 KRT6B

3.26e-051225214610062
Pubmed

Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.

KRT5 PLEC

3.85e-051325222962592
Pubmed

Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.

KRT5 PLEC

3.85e-05132529670011
Pubmed

Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope.

KRT5 DSP

3.85e-05132528999895
Pubmed

PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.

FLG DSP

4.49e-051425229178343
Pubmed

KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.

FLG KRT5 KRT6C DSP

4.62e-0528125426725010
Pubmed

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

KRT5 KRT6B PLEC DSP

4.81e-0528425429459677
Pubmed

Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.

KRT5 DSP

5.18e-05152529847250
Pubmed

Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.

KRT5 KRT6B

5.92e-051625212399393
Pubmed

Comprehensive analysis of keratin gene clusters in humans and rodents.

KRT6B KRT78

5.92e-051625215085952
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

KRT5 KRT78 PLEC KRT6C DSP DDX3X

7.03e-05102425624711643
Pubmed

ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.

KRT5 KRT6B PLEC

7.29e-0511325334474245
Pubmed

Sex differences in sex chromosome gene expression in mouse brain.

DDX3Y DDX3X

7.54e-051825212023983
Pubmed

Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model.

DDX3Y DDX3X

7.54e-051825235762573
Pubmed

Assessment of community efforts to advance network-based prediction of protein-protein interactions.

KRT5 KRT6B KRT78 KRT24 KRT6C

7.55e-0563025536949045
Pubmed

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.

KRT5 KRT6B

8.42e-051925217002498
Pubmed

The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.

KRT5 KRT6B DSP DDX3X

8.60e-0533025432529326
Pubmed

KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis.

KRT5 KRT6B

9.35e-052025238113115
Pubmed

Limb-Girdle Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

DNAJB6 PLEC

1.03e-042125220301582
Pubmed

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.

KRT5 KRT6B

1.03e-042125218824566
Pubmed

EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.

PLEC DDX3X

1.03e-042125233029523
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

DNAJB6 CNOT11 DSP DDX3X EIF4G2

1.07e-0467825530209976
Pubmed

New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.

KRT5 DSP

1.24e-042325218809908
InteractionKRT14 interactions

KRT5 KRT6B KRT78 PLEC KRT6C DSP DDX3X

1.38e-09192237int:KRT14
InteractionKRT5 interactions

KRT5 KRT6B KRT24 KRT6C DSP DDX3X PHTF1

1.43e-09193237int:KRT5
InteractionKRT16 interactions

KRT5 KRT6B KRT78 PLEC KRT6C DSP DDX3X

1.65e-09197237int:KRT16
InteractionKRT13 interactions

DNAJB6 KRT5 KRT6B KRT78 KRT6C DDX3X

2.97e-09116236int:KRT13
InteractionKRT24 interactions

KRT5 KRT6B KRT78 KRT24 KRT6C

3.71e-0954235int:KRT24
InteractionPHTF1 interactions

KRT5 KRT6B KRT6C PHTF1

6.17e-0920234int:PHTF1
InteractionCUL2 interactions

PLEKHA4 DNAJB6 FLG KRT5 KRT78 KRT24 KRT6C DSP DDX3X

8.55e-09591239int:CUL2
InteractionKRT6A interactions

KRT5 KRT6B KRT6C DSP DDX3X PHTF1

2.06e-08160236int:KRT6A
InteractionKRT6C interactions

KRT5 KRT24 PLEC KRT6C PHTF1

2.13e-0876235int:KRT6C
InteractionCHD4 interactions

PLEKHA4 RBM15B FLG KRT5 KRT6B KRT78 KRT6C DSP DDX3X EIF4G2

2.99e-089382310int:CHD4
InteractionHNRNPA1 interactions

PLEKHA4 RBM15B FLG KRT5 KRT6B KRT78 PLEC KRT6C DSP DDX3X

3.21e-089452310int:HNRNPA1
InteractionWTAP interactions

PLEKHA4 RBM15B KRT5 KRT6B KRT78 DSP

6.49e-08194236int:WTAP
InteractionKRT25 interactions

KRT5 KRT6B KRT78 KRT6C

6.59e-0835234int:KRT25
InteractionPRPH interactions

KRT5 KRT6B KRT24 PLEC KRT6C DSP

8.74e-08204236int:PRPH
InteractionEFNA1 interactions

KRT5 KRT6B KRT6C DSP DDX3X

9.89e-08103235int:EFNA1
InteractionACE2 interactions

FLG KRT5 KRT6B KRT78 PLEC KRT6C NUMBL DSP DDX3X EIF4G2

1.41e-0711062310int:ACE2
InteractionCFTR interactions

DNAJB6 FLG KRT5 DDX3Y KRT6B KRT78 KRT24 PLEC KRT6C DSP DDX3X

1.91e-0714802311int:CFTR
InteractionCYLD interactions

DNAJB6 FLG KRT5 KRT6B KRT78 PLEC DSP DDX3X EIF4G2

2.32e-07868239int:CYLD
InteractionKRT84 interactions

KRT5 KRT6B KRT6C PHTF1

2.64e-0749234int:KRT84
InteractionKRT18 interactions

DNAJB6 FLG KRT5 KRT6B PLEC KRT6C DSP

2.94e-07419237int:KRT18
InteractionKRT17 interactions

KRT5 KRT6B KRT78 KRT6C DSP DDX3X

3.04e-07252236int:KRT17
InteractionKRT6B interactions

KRT5 KRT6B KRT24 DDX3X PHTF1

3.42e-07132235int:KRT6B
InteractionHEXIM1 interactions

PLEKHA4 KRT5 DDX3Y KRT6B KRT24 POLQ KRT6C DSP DDX3X

3.56e-07913239int:HEXIM1
InteractionDDX3X interactions

PLEKHA4 FLG KRT5 KRT6B KRT78 DSP DDX3X EIF4G2

3.62e-07651238int:DDX3X
InteractionKRT8 interactions

KRT5 KRT6B KRT24 PLEC KRT6C DSP PHTF1

4.15e-07441237int:KRT8
InteractionKRT19 interactions

KRT5 KRT6B KRT78 PLEC KRT6C DSP

5.88e-07282236int:KRT19
InteractionMETTL3 interactions

DNAJB6 RBM15B KRT5 DDX3Y DSP DDX3X

6.52e-07287236int:METTL3
InteractionKRT20 interactions

KRT5 KRT6B KRT24 KRT6C

7.34e-0763234int:KRT20
InteractionEIF3F interactions

PLEKHA4 DDX3Y KRT6B KRT6C DDX3X EIF4G2

7.81e-07296236int:EIF3F
InteractionKRT36 interactions

KRT5 KRT6B KRT78 KRT6C

1.41e-0674234int:KRT36
InteractionRNF208 interactions

KRT5 KRT6B KRT78 KRT6C

1.48e-0675234int:RNF208
InteractionKRT75 interactions

KRT5 KRT6B KRT24 KRT6C PHTF1

1.63e-06181235int:KRT75
InteractionMETTL14 interactions

FLG KRT5 DDX3Y KRT6B KRT78 PLEC DSP

2.00e-06558237int:METTL14
InteractionKRT78 interactions

KRT78 KRT24 PLEC DDX3X

2.69e-0687234int:KRT78
InteractionIQCB1 interactions

KRT5 KRT6B KRT78 PLEC KRT6C DSP

2.85e-06370236int:IQCB1
InteractionCRK interactions

KRT5 KRT6B KRT78 KRT24 PLEC DDX3X

2.85e-06370236int:CRK
InteractionKRT33B interactions

KRT5 KRT6B KRT78 KRT6C

3.52e-0693234int:KRT33B
InteractionKRT37 interactions

KRT5 KRT6B KRT78 KRT6C

4.70e-06100234int:KRT37
InteractionKRT28 interactions

KRT5 KRT6B KRT6C

5.17e-0630233int:KRT28
InteractionMECP2 interactions

RBM15B FLG KRT5 DDX3Y KRT78 PLEC NUMBL DSP DDX3X

6.19e-061287239int:MECP2
InteractionEFNA3 interactions

KRT5 KRT6B KRT6C DSP

6.38e-06108234int:EFNA3
InteractionKRT35 interactions

KRT5 KRT6B KRT78 KRT6C

7.12e-06111234int:KRT35
InteractionKRT26 interactions

KRT6B KRT78 KRT6C

8.30e-0635233int:KRT26
InteractionCHD3 interactions

KRT5 KRT6B KRT78 KRT6C DSP DDX3X EIF4G2

1.49e-05757237int:CHD3
InteractionRICTOR interactions

PLEKHA4 FLG KRT5 KRT78 PLEC KRT6C DSP

1.51e-05759237int:RICTOR
InteractionMCM2 interactions

PLEKHA4 KRT5 DDX3Y KRT6B PLEC DSP DDX3X EIF4G2

1.59e-051081238int:MCM2
InteractionEFTUD2 interactions

PLEKHA4 KRT5 KRT6B CNOT11 PLEC KRT6C DSP DDX3X EIF4G2

1.62e-051449239int:EFTUD2
InteractionKRT32 interactions

KRT5 KRT6B KRT78

1.67e-0544233int:KRT32
InteractionYWHAH interactions

PLEKHA4 DNAJB6 RBM15B KRT78 PLEC NUMBL DSP DDX3X

1.83e-051102238int:YWHAH
InteractionCASP14 interactions

PLEKHA4 FLG DSP DDX3X

2.73e-05156234int:CASP14
InteractionDES interactions

KRT5 KRT6B KRT6C DSP

2.87e-05158234int:DES
InteractionCUL7 interactions

PLEKHA4 RBM15B KRT5 PLEC KRT6C DSP DDX3X

3.02e-05845237int:CUL7
InteractionDDX39B interactions

KRT5 KRT6B KRT78 PLEC KRT6C DSP

3.34e-05570236int:DDX39B
InteractionKCNA3 interactions

DNAJB6 POLQ NUMBL DSP DDX3X PHTF1 EIF4G2

3.67e-05871237int:KCNA3
InteractionKRT38 interactions

KRT5 KRT6B KRT78 KRT6C

4.00e-05172234int:KRT38
InteractionKRT39 interactions

KRT6B KRT78 PLEC

4.05e-0559233int:KRT39
InteractionZUP1 interactions

KRT5 KRT6B KRT78 DSP

4.18e-05174234int:ZUP1
InteractionKRT15 interactions

KRT5 KRT6B KRT78 KRT6C

4.57e-05178234int:KRT15
InteractionOBSL1 interactions

PLEKHA4 KRT5 KRT6B PLEC POLQ DSP DDX3X

4.59e-05902237int:OBSL1
InteractionEIF4G2 interactions

PLEKHA4 DNAJB6 DDX3X EIF4G2

4.67e-05179234int:EIF4G2
InteractionHDAC6 interactions

DNAJB6 KRT5 KRT6B KRT24 PLEC DSP DDX3X

5.54e-05929237int:HDAC6
InteractionALB interactions

PLEKHA4 KRT5 KRT6B KRT78 DDX3X

6.76e-05391235int:ALB
InteractionRLIM interactions

KRT5 KRT78 KRT24 DSP DDX3X

6.84e-05392235int:RLIM
InteractionKRT27 interactions

KRT5 KRT6B KRT78 KRT6C

7.47e-05202234int:KRT27
InteractionEIF4B interactions

PLEKHA4 DDX3Y DSP DDX3X EIF4G2

7.71e-05402235int:EIF4B
InteractionLRRC31 interactions

KRT5 KRT78 PLEC DSP

7.91e-05205234int:LRRC31
InteractionCNOT3 interactions

PLEKHA4 CNOT11 DSP DDX3X

8.21e-05207234int:CNOT3
InteractionCOPS6 interactions

PLEKHA4 KRT5 KRT24 DSP DDX3X

8.26e-05408235int:COPS6
InteractionPTDSS1 interactions

GPLD1 FLG PLEC DSP

9.01e-05212234int:PTDSS1
InteractionINPPL1 interactions

KRT5 KRT6B KRT6C DDX3X

9.34e-05214234int:INPPL1
InteractionRNF8 interactions

FLG KRT5 KRT6B KRT78 DSP

9.58e-05421235int:RNF8
InteractionKRT7 interactions

KRT5 KRT6B KRT6C

1.01e-0480233int:KRT7
InteractionLATS1 interactions

PLEKHA4 KRT5 KRT78 PLEC KRT6C

1.18e-04440235int:LATS1
InteractionKRT3 interactions

KRT5 KRT24 PHTF1

1.34e-0488233int:KRT3
InteractionKRT2 interactions

KRT5 KRT24 DDX3X PHTF1

1.36e-04236234int:KRT2
InteractionKRT1 interactions

KRT5 KRT24 DSP DDX3X

1.41e-04238234int:KRT1
InteractionEFNA4 interactions

KRT5 KRT6B KRT6C DSP

1.43e-04239234int:EFNA4
InteractionRIN3 interactions

DNAJB6 KRT5 PLEC DSP DDX3X

1.50e-04463235int:RIN3
InteractionCOPS5 interactions

KRT5 KRT6B KRT78 KRT24 KRT6C DSP DDX3X

1.62e-041102237int:COPS5
InteractionLARP7 interactions

FLG KRT5 DDX3Y KRT6B KRT6C DSP DDX3X

1.72e-041113237int:LARP7
InteractionPRPF8 interactions

PLEKHA4 KRT5 KRT6B PLEC DSP DDX3X

1.84e-04776236int:PRPF8
InteractionKDM5B interactions

PLEKHA4 RBM15B TMEM121B

1.95e-04100233int:KDM5B
InteractionQSER1 interactions

DNAJB6 KRT78 PLEC

1.95e-04100233int:QSER1
InteractionPICALM interactions

PLEKHA4 DNAJB6 DDX3Y DDX3X

2.06e-04263234int:PICALM
InteractionVIM interactions

PLEKHA4 KRT5 KRT6B PLEC KRT6C DSP

2.23e-04804236int:VIM
InteractionNUP62 interactions

PLEKHA4 KRT6B HEATR5A DDX3X

2.38e-04273234int:NUP62
InteractionDCUN1D1 interactions

KRT5 KRT24 DDX3X EIF4G2

2.45e-04275234int:DCUN1D1
InteractionTRIM58 interactions

KRT5 DDX3X

2.58e-0421232int:TRIM58
InteractionFLG2 interactions

FLG DSP DDX3X

2.73e-04112233int:FLG2
InteractionKRT34 interactions

KRT5 KRT78 PLEC KRT6C

2.73e-04283234int:KRT34
InteractionMC1R interactions

PLEKHA4 POMC

2.84e-0422232int:MC1R
InteractionCIAO1 interactions

PLEKHA4 DNAJB6 RBM15B DSP

2.96e-04289234int:CIAO1
InteractionUSP11 interactions

PLEKHA4 RBM15B DDX3Y KRT78 DDX3X

3.03e-04539235int:USP11
InteractionTTLL12 interactions

PLEKHA4 DNAJB6 DDX3X

3.10e-04117233int:TTLL12
InteractionUSP4 interactions

PLEKHA4 PLEC DDX3X EIF4G2

3.12e-04293234int:USP4
InteractionMEPCE interactions

RBM15B KRT5 DDX3Y KRT6B KRT6C DDX3X

3.19e-04859236int:MEPCE
InteractionHDAC2 interactions

PLEKHA4 KRT5 KRT6B KRT78 DDX3X EIF4G2

3.31e-04865236int:HDAC2
InteractionKRT12 interactions

KRT5 KRT6B

3.39e-0424232int:KRT12
InteractionCUL1 interactions

PLEKHA4 KRT5 KRT6B KRT24 KRT6C DDX3X

3.54e-04876236int:CUL1
InteractionHEATR5A interactions

PLEKHA4 HEATR5A

3.68e-0425232int:HEATR5A
Cytoband12q13.13

KRT5 KRT6B KRT78 KRT6C

5.12e-086725412q13.13
CytobandEnsembl 112 genes in cytogenetic band chr12q13

KRT5 KRT6B KRT78 KRT6C

7.71e-05423254chr12q13
Cytoband2p23.3

POMC AGBL5

6.34e-04682522p23.3
Cytoband6p22.1

GPLD1 POM121L2

2.72e-031422526p22.1
CytobandEnsembl 112 genes in cytogenetic band chr2p23

POMC AGBL5

2.99e-03149252chr2p23
CytobandEnsembl 112 genes in cytogenetic band chr6p22

GPLD1 POM121L2

1.79e-02378252chr6p22
GeneFamilyKeratins, type II

KRT5 KRT6B KRT78 KRT6C

1.19e-0827184609
GeneFamilyEF-hand domain containing|Plakins

PLEC DSP

2.61e-058182939
GeneFamilyDEAD-box helicases

DDX3Y DDX3X

7.87e-0442182499
CoexpressionDESCARTES_MAIN_FETAL_SQUAMOUS_EPITHELIAL_CELLS

KRT6B KRT78 KRT6C DSP

5.51e-06129244M40122
CoexpressionDESCARTES_FETAL_STOMACH_SQUAMOUS_EPITHELIAL_CELLS

KRT5 KRT6B KRT6C

3.11e-0567243M40299
CoexpressionZENG_GU_POST_ICB_METAGENE_39

GPLD1 KRT5 KRT6B KRT78

3.35e-05204244MM17090
CoexpressionJI_CARCINOGENESIS_BY_KRAS_AND_STK11_UP

KRT5 KRT6B

6.23e-0513242MM743
CoexpressionJAEGER_METASTASIS_DN

FLG KRT5 KRT6B DSP

8.60e-05260244M10702
CoexpressionGSE13887_HEALTHY_VS_LUPUS_RESTING_CD4_TCELL_UP

POM121L2 KRT5 KRT6B

1.60e-04116243M1889
CoexpressionAtlasesophagus

KRT5 KRT6B KRT78 KRT24 KRT6C DSP

2.63e-07247246esophagus
CoexpressionAtlasBM Top 100 - esophagus

KRT5 KRT6B KRT78 DSP

2.50e-0686244BM Top 100 - esophagus
CoexpressionAtlasAravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_1000_k-means-cluster#5

KRT5 KRT6B KRT24 KRT6C

1.04e-05123244Arv_EB-LF_1000_K5
CoexpressionAtlasAravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_2500_k-means-cluster#3

KRT5 KRT6B KRT24 KRT6C DSP

2.73e-05325245Arv_EB-LF_2500_K3
CoexpressionAtlasAravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_500_k-means-cluster#4

KRT5 KRT6B KRT6C

3.96e-0559243Arv_EB-LF_500_K4
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_reference_BronchioEpithel_top-relative-expression-ranked_1000

KRT5 KRT6B KRT78 KRT24 PLEC KRT6C DSP

8.07e-05990247PCBC_ctl_BronchioEpithel_1000
CoexpressionAtlasBM Top 100 - vagina

KRT5 KRT6B DSP

8.45e-0576243BM Top 100 - vagina
CoexpressionAtlasBM Top 100 - tongue superior part w_papillae

KRT5 KRT6B DSP

9.48e-0579243BM Top 100 - tongue superior part w_papillae
CoexpressionAtlasBM Top 100 - tongue main corpus

KRT5 KRT6B DSP

9.84e-0580243BM Top 100 - tongue main corpus
CoexpressionAtlasBM Top 100 - oral mucosa

KRT6B KRT78 DSP

1.10e-0483243BM Top 100 - oral mucosa
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_reference_BronchioEpithel_top-relative-expression-ranked_100

KRT5 KRT6B KRT6C

1.80e-0498243PCBC_ctl_BronchioEpithel_100
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_reference_SmallAirwayEpithel_top-relative-expression-ranked_100

KRT5 KRT6B KRT6C

1.80e-0498243PCBC_ctl_SmallAirwayEpithel_100
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#1_top-relative-expression-ranked_200

KRT5 DSP

3.33e-0424242gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_200_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#5_top-relative-expression-ranked_500

KRT5 DSP

6.33e-0433242gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_500_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_k-means-cluster#1_top-relative-expression-ranked_500

KRT5 DSP

7.53e-0436242gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_500_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_emap-30875_top-relative-expression-ranked_200

GPLD1 KRT5 DSP

8.71e-04168243gudmap_developingLowerUrinaryTract_e13.5_bladder neck-urethr epithel_200
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-leukocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT5 KRT6B KRT78 PLEC KRT6C DSP

1.08e-09197256d968d7d5608b175bb567ea3a315bf473ec3be459
ToppCellfacs-Trachea-18m|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KRT5 KRT6B KRT78 KRT24 DSP

4.44e-0817725568c9a8a82c956cbfdf03b44984c97f978aaaf80f
ToppCellfacs-Trachea-nan-18m|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT6B KRT78 KRT24 DSP

4.44e-08177255fc30276903bcb1e95ae76f6cee3d17408158941a
ToppCellfacs-Trachea-nan-18m-Epithelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT6B KRT78 KRT24 DSP

5.84e-081872558882a638af7165b2910ba8e932d55475d7bfb003
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KRT5 KRT6B KRT78 KRT24 DSP

6.49e-08191255cd4e2e883c4955fb2d875e41bb6ebc680994dc8c
ToppCellfacs-Trachea-nan-18m-Epithelial-new-cluster|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT6B KRT78 KRT24 DSP

6.66e-08192255e4fb3f18da7dc6a835023db69a8d99737c39ef86
ToppCellfacs-Trachea-nan-18m-Epithelial-keratinocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT6B KRT78 KRT24 DSP

6.66e-081922554530b3028928d089b3a71eb19a4df237f58a50ae
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT5 KRT6B KRT78 KRT6C DSP

7.38e-0819625503de28e1c963e99623e8b0e33bf2e8ef67dc3baa
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT6B KRT24 KRT6C DSP

7.57e-08197255fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT6B KRT24 KRT6C DSP

7.57e-0819725561c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCelldistal-1-Epithelial-Basal|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLG KRT5 KRT6B KRT6C DSP

7.57e-0819725525a2ccc98b973611de0d920b1b455d0b40f0d37f
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT6B KRT24 KRT6C DSP

7.57e-08197255dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-leukocyte|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT5 KRT6B KRT78 KRT6C DSP

7.57e-08197255e621d4f9d4ba5e3ef17d2b477e5e14ea0251147e
ToppCelldistal-Epithelial-Basal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLG KRT5 KRT6B KRT6C DSP

7.57e-0819725575b4292ce2ad7f9c8b6a4781e1cb71f5b18b74e3
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT6B KRT24 KRT6C DSP

7.57e-081972552430f31d9312338e0ca23bfc6bdb0365340860fd
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT6B KRT24 KRT6C DSP

7.76e-08198255e06d41a7254a09e037ec404be2d8c352d5cbd7f4
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

DNAJB6 KRT5 KRT6B KRT6C DSP

7.96e-081992558be7cb9d8b4f9707efb69c681c40e683fcd810e5
ToppCelldistal-Epithelial-Basal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PLEKHA4 FLG KRT5 KRT6C DSP

8.16e-082002555c14f0c09bb8b3daf6d649032e888a7880c52b73
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 DDX3Y KRT78 DSP

1.38e-06149254d259e9137109eeb2662022f0915ca463f5bebdfe
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-4|TCGA-Stomach / Sample_Type by Project: Shred V9

KRT5 KRT78 KRT24 KRT6C

1.98e-061632546a12b802cb181f979ebc72674f3626fb855024e3
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-6|TCGA-Bladder / Sample_Type by Project: Shred V9

KRT5 KRT6B KRT6C DSP

2.39e-061712540e78389f8f3d54570a6deb3dd307b865b46307e9
ToppCellTCGA-Head_and_Esophagus|World / Sample_Type by Project: Shred V9

KRT5 KRT6B KRT78 KRT6C

2.45e-06172254eb18aa179db1818f408c38e442ecfed8582d7dbc
ToppCellPND07-Epithelial-Epithelial_Airway-Basal-Basal-Basal_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT5 KRT6B KRT78 DSP

2.51e-061732541b2508cc890430bd4b2cf232c633928edb86c57e
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-5|TCGA-Lung / Sample_Type by Project: Shred V9

KRT5 KRT6B KRT78 KRT6C

2.75e-06177254a0c7d08469c513cecf87777c19876884f1511570
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLG KRT5 KRT6B KRT6C

3.07e-06182254007fa56ed8b91f9af0df2114c00410b2f6cec8b6
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLG KRT6B KRT78 KRT24

3.27e-06185254f3fbc3096f85397a959cee17c3c4fcf2d511f3d5
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT6B KRT6C DSP

3.41e-06187254a6a112689d1c9049f57935ad9d2f4955538427de
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

KRT5 KRT6B KRT6C DSP

3.56e-06189254533c302df467d13ab639232daf4f8cafb808260b
ToppCellTCGA-Skin-Primary_Tumor|TCGA-Skin / Sample_Type by Project: Shred V9

KRT5 KRT6B KRT78 KRT6C

3.64e-06190254e2b26a03c6ab24d9b0f4150c47597be37767d86e
ToppCellTCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

KRT5 KRT6B KRT78 KRT6C

3.64e-061902543188c7bd225cbcf46a21e2fb784336cdd9665995
ToppCellTCGA-Skin-Primary_Tumor-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

KRT5 KRT6B KRT78 KRT6C

3.64e-0619025401fb45add4661bc86cd0a34fac35177907152dbb
ToppCellfacs-Skin|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 PLEC DSP

3.71e-06191254ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCellfacs-Trachea-18m-Epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KRT5 KRT6B KRT24 DSP

3.79e-06192254c5823c5d4c58a4e9121a4b7d7256481d6d9e9b7f
ToppCellfacs-Thymus-nan-3m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBM15B DDX3Y DDX3X EIF4G2

3.95e-0619425466c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCellfacs-Thymus-nan-3m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBM15B DDX3Y DDX3X EIF4G2

3.95e-06194254f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCellNS-critical-d_0-4-Epithelial-Squamous|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KRT5 KRT6B KRT78 KRT24

3.95e-06194254614d0c25b56957c70f397abb169fd2a860eb1c06
ToppCellfacs-Thymus-nan|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBM15B DDX3Y DDX3X EIF4G2

3.95e-06194254cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHA4 FLG KRT6B KRT6C

4.11e-06196254279f43deeba4528cd63f5217a8441b5452bf0b16
ToppCellBronchus_Control_(B.)|World / Sample group, Lineage and Cell type

KRT5 DDX3Y KRT6B DSP

4.20e-06197254b6dff2ee108813e18657e2d8cf850e2423f8c8e9
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 KRT6B KRT6C DSP

4.20e-061972549ee927d005eb17843e2516c8006eb192c6ad2af8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-Plasma_B|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 KRT6B KRT6C DSP

4.28e-0619825496236fa22545f6f4ff3aa8dc002963db8a3468ce
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 KRT6B KRT6C DSP

4.28e-061982549e0fdd63069d17430cdc25bf4ffc762afd5e1728
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 KRT6B KRT6C DSP

4.28e-061982547eb521af938c2609a85d27e2aa7d4317ad6e1e44
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 KRT6B KRT6C DSP

4.28e-061982543371276410dba693c238b383d990b89371b14d8d
ToppCell(04)_Interm._basal>secr.-(1)_GFP|(04)_Interm._basal>secr. / shred by cell type by condition

KRT5 KRT6B PLEC EIF4G2

4.37e-061992547a0d40d4679dc373829d67693851428f41c8b0d6
ToppCelldistal-1-Epithelial-Proliferating_Basal|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT5 KRT6B KRT6C DSP

4.37e-0619925493450257180d918c310bca7b5defc74390c48091
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KRT5 KRT6B KRT6C DSP

4.46e-06200254c7668e26c6b8cfa6d174b0634e43c230425faba9
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KRT5 KRT6B KRT6C DSP

4.46e-06200254621dd6438ef6e71811d3644b75209535b7c0f8f7
ToppCellParenchyma_COVID-19-Epithelial-TX-Basal_2|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

KRT5 KRT6B KRT6C DSP

4.46e-06200254bce9bce9eb622bc6514708d49ca4a6604043c22a
ToppCelldistal-Epithelial-Proliferating_Basal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT5 KRT6B KRT6C DSP

4.46e-06200254cc31e8c28d01e6757c5dd7f485db6acf7409a47e
ToppCellBronchus_Control_(B.)-Epithelial-TX-Basal_2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

KRT5 KRT6B KRT24 DSP

4.46e-062002540fa3340d945f00ef55c7603476d51bd8346e82c2
ToppCelldistal-Epithelial-Proliferating_Basal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT5 KRT6B KRT6C DSP

4.46e-0620025425cc494ef831511840d8c02ec1bd086635cc7edd
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-6|TCGA-Bladder / Sample_Type by Project: Shred V9

FLG KRT6B KRT6C

3.78e-05117253e13c50260d81e8f2ea99e5c680c9699da246067b
ToppCellBronchial_Brush-Epithelial-Ciliated_2|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

FLG KRT78 KRT24

5.42e-05132253780a391924f776dc6fbe44ddcf4ae0583a1e2157
ToppCellBronchial_Brush-Epithelial-Ciliated_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

FLG KRT78 KRT24

5.79e-05135253366a417f9ef7c0d86e9f262d97bf788f478315ee
ToppCellTCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue-4|TCGA-Stomach / Sample_Type by Project: Shred V9

FLG KRT78 KRT6C

9.06e-051572532553ebf3e48de5bd184e77bd61114faa5a1d95ed
ToppCellfacs-Heart-LA-24m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDX3Y KRT6B KRT24

9.76e-05161253248487415a0601d57ef2a6692e22a61368d0b9c8
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|356C / Donor, Lineage, Cell class and subclass (all cells)

GPLD1 HEATR5A POLQ

9.94e-051622537d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Keratinizing_Cervical_Squamous_Cell_Carcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

KRT5 KRT6B KRT6C

1.03e-04164253de1646dbcf2a10b48e021acf7dc63e803e6a47ce
ToppCellLPS_only-Epithelial_airway-Club_cells-Airway|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KRT5 KRT78 DSP

1.03e-04164253b1243b10591e1e15a94952e39ffbf382eae6aae8
ToppCellLPS_only-Epithelial_airway|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KRT5 KRT78 DSP

1.03e-0416425356e6934e6c7503a300d7be06762d45a1d6f1ae0f
ToppCellLPS_only-Epithelial_airway-Club_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KRT5 KRT78 DSP

1.03e-04164253c5b2001280a43da855017361a3f6071a0e492848
ToppCellLPS-IL1RA-Epithelial_airway-Club_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KRT5 KRT78 DSP

1.05e-041652531a114eacaab598f755a173a3fed842ba91f689dd
ToppCellLPS-IL1RA-Epithelial_airway-Club_cells-Airway|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KRT5 KRT78 DSP

1.05e-041652539cfd3c1d2c6d714fde83b90465f1f9741b0e50ce
ToppCellnormal_Lung-Fibroblasts-Mesothelial_cells|Fibroblasts / Location, Cell class and cell subclass

KRT5 KRT78 DSP

1.09e-04167253892a2dc83ab5de5a1016402f8e95d2aabf651326
ToppCellNS-moderate-d_0-4-Epithelial-Squamous|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FLG KRT78 KRT24

1.13e-041692534a5d023ffcf83312d29b1d215eb6b744ef1a0777
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 POLQ DSP

1.17e-04171253121e63ca281ad765d76c2afb3b4d441329b47f81
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT24 DSP

1.23e-04174253207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCellPND10-Epithelial-Epithelial_Airway-Basal-Basal-Basal_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT5 KRT6B DSP

1.23e-0417425397d4a40b536a67fa52f055eab26106d041bf3220
ToppCellPND10-Epithelial-Epithelial_Airway-Basal-Basal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT5 KRT6B DSP

1.23e-04174253f9f399244c7d12caf8118ec3117d477a39e35c3b
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_3|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KRT5 KRT6B DSP

1.23e-041742539e5fae9ecc7c0111fc8a252e72b89dc89c0d3a7c
ToppCellPND10-Epithelial-Epithelial_Airway-Basal|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT5 KRT6B DSP

1.23e-04174253e8440eea7c81864defa57c89e9b569ad8033e5c5
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KRT5 KRT6B DSP

1.27e-041762538d9d0fb46c418b2067be58aec822e8c2b1561461
ToppCellwk_15-18-Epithelial-Proximal_epithelial-SMG_basal_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KRT5 KRT6B DSP

1.27e-04176253045b12c90f7dd49a9778dadcdf8f18125b380531
ToppCellfacs|World / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 PLEC DSP

1.34e-041792538001db3044e8657980e24422377c4fdb0d7b323e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 DSP

1.38e-04181253a5e770b5b5d57cbac18560828e89f7c96b687743
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 DSP

1.38e-04181253504b1af1951a7a20ef5db69d84c20630ec64095b
ToppCellPND07-Epithelial-Epithelial_Airway-Basal|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT5 KRT6B DSP

1.38e-04181253f50561fdacfb83ba85fe6476e7cbc2bad1ebc826
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 DSP

1.38e-04181253a55ec36d2393f7a376feb42b22aee75dfdf4c383
ToppCellPND07-Epithelial-Epithelial_Airway-Basal-Basal|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KRT5 KRT6B DSP

1.38e-041812536b43dcaeeb02ad5900772b6f16f1581847050e38
ToppCellPSB-critical-LOC-Epithelial-Squamous|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FLG KRT78 KRT24

1.43e-041832532cf798a2371c61322484ea16fdfae0acfa94f102
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 DSP

1.43e-0418325382b84ee065fb573688d59da97a327152a1ba294c
ToppCellfacs-Brain_Non-Myeloid-Striatum_|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 DSP

1.43e-04183253824ecda1219fb596a01bf5cfeee29a6daa462098
ToppCellfacs-Lung-24m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KRT5 KRT24 DSP

1.43e-041832536e5b39c0170d62eb7fdd411dcfff51ed176573d0
ToppCellwk_15-18-Epithelial-Proximal_epithelial-basal_proximal|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KRT5 KRT78 DSP

1.45e-04184253575de705053da8b289670b5c40c1627c0833b5ed
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 DDX3Y DSP

1.47e-04185253eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBM15B DDX3Y EIF4G2

1.47e-04185253d50406a9a5b8d75110ba5985741aa2293950c543
ToppCellfacs-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RBM15B DDX3Y EIF4G2

1.47e-04185253a2cae8c657e4f4d121476798e424876f7e247973
ToppCellfacs-BAT-Fat-24m-Epithelial-Epcam+|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPLD1 KRT5 KRT24

1.50e-04186253b18d7398279a2d42414318aeb70514fd402f5a0a
ToppCelldroplet-Lung-LUNG-1m-Epithelial-Club_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHA4 POMC DSP

1.50e-04186253e52cf44989c57c433bf82e9fa13b4643e88f3577
ToppCelldroplet-Tongue-nan-24m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT6B KRT24 DSP

1.50e-041862532913b5fd0617d024d600ba7015ec7b1961dade83
ToppCelldroplet-Lung-LUNG-1m-Epithelial-club_cell_of_bronchiole|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHA4 POMC DSP

1.50e-041862534c0b59d845b79323e7a3287e7c4d249f5f322556
ToppCellTCGA-Skin-Primary_Tumor-Melanoma-Skin_Cutaneous_Melanoma-6|TCGA-Skin / Sample_Type by Project: Shred V9

KRT6B KRT78 KRT6C

1.52e-041872532ca7928baf0c5e61f7294ed05e6e6f0e0adf9d3f
ToppCellfacs-Tongue-nan-24m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT6B KRT24 DSP

1.54e-04188253ed35e438796cef302b6787c111753425922792dc
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 DSP

1.57e-041892536f0fc5271a7d3682f145e734abc3be6473dda2e2
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 DSP

1.57e-041892533b9ce8964b16cb2200d30cbb0bfc711dcad2380e
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 KRT24 DSP

1.57e-0418925338acb307907fde68b992057714448c1561d69ee3
ToppCellSupraBC-Differ-KC|World / shred by cell class for mouse tongue

KRT6B KRT24 DSP

1.57e-041892536412741b88e241304033b41effca0c77a374d907
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

KRT5 KRT6B KRT6C

1.57e-04189253aa4f7d7a5196e5ae481ebc2549de8e3f0ef6e6be
ToppCellfacs-GAT-Fat-3m|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT5 DDX3X EIF4G2

1.59e-041902531d92be1b41cff59e834a9d28868f554bd1f3e471
ComputationalKeratin.

KRT5 KRT6B DSP

1.19e-0526193MODULE_298
ComputationalGenes in the cancer module 68.

KRT5 KRT6B DSP

1.19e-0526193MODULE_68
ComputationalGenes in the cancer module 153.

KRT5 KRT6B DSP

2.71e-0534193MODULE_153
ComputationalIntermediate filaments and MT.

KRT5 KRT6B DSP

2.18e-0468193MODULE_438
ComputationalGenes in the cancer module 297.

KRT5 KRT6B DSP

3.53e-0480193MODULE_297
ComputationalIntermediate filaments and keratins.

KRT5 KRT6B DSP

3.53e-0480193MODULE_357
Drug1-2q

KRT5 KRT6B KRT24 PLEC KRT6C NUMBL DSP

1.42e-08289247CID000011820
DrugAC1L9MJT

KRT5 KRT6B KRT24 PLEC KRT6C

1.51e-06192245CID000448959
Drugplakin

KRT6B PLEC KRT6C DSP

1.57e-0682244CID000018752
Drugphorbol acetate myristate

POMC GPLD1 KRT5 KRT6B KRT24 POLQ KRT6C PHTF1 EIF4G2

6.85e-061399249CID000004792
Drugteleocidin B

KRT5 KRT6B KRT24 KRT6C

7.93e-06123244CID000072425
Drugsulfur mustard

KRT5 KRT6B KRT24 KRT6C

9.87e-06130244CID000010461
Drughomocysteine thiolactone

KRT5 KRT6B KRT24 KRT6C

1.02e-05131244CID000107712
DrugSC-791

KRT6B KRT6C

1.59e-056242CID010291510
DrugClOClO

KRT5 KRT78

1.59e-056242CID000517862
Drugphenyl isocyanate

KRT5 KRT6B

1.59e-056242ctd:C025319
Drugmant-GTP

KRT6B PLEC KRT6C

1.95e-0550243CID000128647
Drugal-Badry

KRT5 KRT6B KRT24 KRT6C

2.52e-05165244CID000004545
DrugDIMIT

KRT5 KRT6B KRT6C

2.75e-0556243CID000006624
DrugMephentermine hemisulfate [1212-72-2]; Up 200; 9.4uM; MCF7; HT_HG-U133A

GPLD1 KRT24 DDX3X EIF4G2

3.95e-051852444707_UP
DrugNapelline [5008-52-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A

GPLD1 POM121L2 DDX3Y KRT6B

4.95e-051962446824_UP
Drug(-)-Isoproterenol hydrochloride [5984-95-2]; Up 200; 16.2uM; MCF7; HT_HG-U133A

KRT6B KRT24 PLEC DDX3X

4.95e-051962443571_UP
Drug1,4-pentanediamine

KRT6B KRT6C EIF4G2

6.61e-0575243CID000550880
Drug4-hydroxytestosterone

KRT5 KRT6B KRT6C

7.43e-0578243CID000160615
DrugAC1L9LMC

KRT6B PLEC KRT6C

8.95e-0583243CID000448113
DrugAC1L1GT5

KRT5 NUMBL DSP

1.34e-0495243CID000003829
Drugclobestasol propionate

KRT6B KRT6C

1.43e-0417242CID000002791
Drugphorbol 12-myristate

GPLD1 KRT5 KRT6B KRT6C

1.50e-04261244CID000107854
Drugdithranol

KRT6B KRT6C

1.61e-0418242CID000002202
DrugN1-acetylspermidine

KRT6B KRT6C

2.00e-0420242CID000000496
DrugOlux

KRT6B KRT6C

2.00e-0420242CID000032797
Diseasechildhood medulloblastoma (implicated_via_orthology)

DDX3Y DDX3X

5.81e-072232DOID:3869 (implicated_via_orthology)
DiseaseSertoli cell-only syndrome (implicated_via_orthology)

DDX3Y DDX3X

3.48e-064232DOID:0050457 (implicated_via_orthology)
Diseaseepidermolysis bullosa simplex (is_implicated_in)

KRT5 PLEC

1.22e-057232DOID:4644 (is_implicated_in)
DiseaseLimb-girdle muscular dystrophy

DNAJB6 PLEC

1.87e-0426232cv:C0686353
DiseaseMuscular Dystrophies, Limb-Girdle

DNAJB6 PLEC

2.84e-0432232C0686353

Protein segments in the cluster

PeptideGeneStartEntry
LSRARSFSTGTSAGG

AGBL5

636

Q8NDL9
ARGQSGESSGRSGSF

FLG

2076

P20930
RTSFAREGSFRLSGG

NUMBL

216

Q9Y6R0
GGGGSSRRSSSSSAA

RBM15B

221

Q8NDT2
KSSFFSDRGSGSRGR

DDX3X

81

O00571
GRSKSSRFSGGFGAR

DDX3X

586

O00571
SGFSSISVSRSRGSG

KRT6C

31

P48668
ISTSGGSFRNRFGAG

KRT5

76

P13647
SGFSSISVSRSRGSG

KRT6B

31

P04259
RFGRRNSSSSGSSGA

POMC

86

P01189
RGSGFCGSSRFSSGA

KRT24

101

Q2M2I5
SRGGFSSRGGFSSRS

KRT78

26

Q8N1N4
SSRGGFSSRSLNSFG

KRT78

31

Q8N1N4
SRFSASSGGGGSRGA

EIF4G2

11

P78344
GSRSRGTGSFFSAFS

DNAJB6

131

O75190
GTGFLRGSSGFLRAS

HEATR5A

271

Q86XA9
RRSESGSDSFSGSGG

POLQ

11

O75417
SGSRSGSRSGSRSGS

DSP

2831

P15924
SRSGSRRGSFDATGN

DSP

2841

P15924
GSRGRSKSNRFSGGF

DDX3Y

581

O15523
SFRGRRGSGDSSTST

TMEM121B

36

Q9BXQ6
VANSGSTGFSRRGSG

PLEKHA4

726

Q9H4M7
GSVGRGPFRSSASSF

POM121L2

996

Q96KW2
GSREAAGSASRSGFG

CNOT11

21

Q9UKZ1
AFSQGSRSGVSGGSR

PHTF1

346

Q9UMS5
LSTFSGDRRFSRFGG

GPLD1

706

P80108
AGSRRGSFDATGSGF

PLEC

4636

Q15149
SSRFSGRGSGTDFTL

IGKV1D-42

81

A0A075B6H8