Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGTPase activator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ELMOD2 ARHGAP11A CHN1 TBC1D3C TBC1D3I TBC1D3G TBC1D3K TBC1D3F

1.24e-092799913GO:0005096
GeneOntologyMolecularFunctionenzyme activator activity

TBC1D3E TBC1D3 ERCC6 TBC1D3H TBC1D3L TBC1D3D ELMOD2 ADRM1 ARHGAP11A CHN1 TBC1D3C PRKCD TBC1D3I TBC1D3G AIM2 TBC1D3K TBC1D3F

2.21e-086569917GO:0008047
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ELMOD2 DOCK10 ARHGAP11A CHN1 TBC1D3C ELMO1 TBC1D3I TBC1D3G TBC1D3K TBC1D3F

2.91e-085079915GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D ELMOD2 DOCK10 ARHGAP11A CHN1 TBC1D3C ELMO1 TBC1D3I TBC1D3G TBC1D3K TBC1D3F

2.91e-085079915GO:0030695
GeneOntologyMolecularFunctionenzyme regulator activity

TBC1D3E TBC1D3 ERCC6 TBC1D3H TBC1D3L TBC1D3D ELMOD2 ING2 ADRM1 DOCK10 ARHGAP11A CHN1 TBC1D3C ELMO1 PRKCD TBC1D3I TBC1D3G AIM2 TBC1D3K TBC1D3F

1.77e-0514189920GO:0030234
GeneOntologyMolecularFunctionmolecular function activator activity

TBC1D3E TBC1D3 ERCC6 TBC1D3H TBC1D3L TBC1D3D ELMOD2 ADRM1 ARHGAP11A CHN1 TBC1D3C PRKCD IL1B TBC1D3I TBC1D3G AIM2 TBC1D3K TBC1D3F

3.19e-0512339918GO:0140677
GeneOntologyMolecularFunctionmethylated histone binding

ING1 ING2 ZMYND8 MSL3

8.84e-0486994GO:0035064
GeneOntologyMolecularFunctionmethylation-dependent protein binding

ING1 ING2 ZMYND8 MSL3

9.64e-0488994GO:0140034
GeneOntologyBiologicalProcesspositive regulation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK10 ARHGAP11A CHN1 TBC1D3C TBC1D3I SNX9 TBC1D3G TBC1D3K TBC1D3F

7.32e-122449614GO:0043547
GeneOntologyBiologicalProcesspositive regulation of hydrolase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK10 ARHGAP11A CHN1 TBC1D3C PPARGC1B PRKCD TBC1D3I SNX9 TBC1D3G AIM2 TBC1D3K EPHA4 TBC1D3F

1.43e-114999618GO:0051345
GeneOntologyBiologicalProcessregulation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK10 ARHGAP11A CHN1 TBC1D3C TBC1D3I SNX9 TBC1D3G TBC1D3K EPHA4 TBC1D3F

4.21e-113359615GO:0043087
GeneOntologyBiologicalProcessactivation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3I TBC1D3G TBC1D3K TBC1D3F

8.61e-111099610GO:0090630
GeneOntologyBiologicalProcessregulation of hydrolase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK10 ARHGAP11A CHN1 TBC1D3C PPARGC1B PRKCD TBC1D3I SNX9 TBC1D3G AIM2 TBC1D3K EPHA4 TBC1D3F

1.06e-078789618GO:0051336
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK10 ARHGAP11A CHN1 TBC1D3C PPARGC1B PRKCD IL1B TBC1D3I SNX9 TBC1D3G AIM2 TBC1D3K EPHA4 TBC1D3F

2.22e-0710289619GO:0043085
GeneOntologyBiologicalProcesspositive regulation of molecular function

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D DOCK10 ARHGAP11A CHN1 TBC1D3C PPARGC1B PLCL2 PRKCD IRAK3 PLCL1 IL1B TBC1D3I SNX9 TBC1D3G AIM2 TBC1D3K EPHA4 TBC1D3F

4.98e-0714309622GO:0044093
GeneOntologyBiologicalProcesspositive regulation of stem cell population maintenance

OGT ING1 ING2 SMARCE1

9.31e-0551964GO:1902459
GeneOntologyCellularComponentpostsynaptic cytosol

OGT PIAS1 UBE3A PRKCD SUMO2

2.38e-06451005GO:0099524
GeneOntologyCellularComponentcytosolic region

OGT PIAS1 UBE3A PRKCD SUMO2

2.14e-05701005GO:0099522
GeneOntologyCellularComponentSin3-type complex

OGT ING1 ING2

1.53e-04221003GO:0070822
DomainTBC

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3I TBC1D3G TBC1D3K TBC1D3F

3.26e-1249979SM00164
DomainRabGAP-TBC

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3I TBC1D3G TBC1D3K TBC1D3F

6.91e-1253979PF00566
DomainTBC_RABGAP

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3I TBC1D3G TBC1D3K TBC1D3F

9.82e-1255979PS50086
DomainRab-GTPase-TBC_dom

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3I TBC1D3G TBC1D3K TBC1D3F

9.82e-1255979IPR000195
DomainZinc_finger_PHD-type_CS

KDM5B ING1 ING2 ZMYND8 SP140L PHF3

1.08e-0665976IPR019786
DomainPHD

KDM5B ING1 ING2 ZMYND8 SP140L PHF3

2.53e-0675976PF00628
DomainPH_12

ELMO1 PLCL2 PLCL1

2.69e-066973PF16457
DomainZnf_PHD-finger

KDM5B ING1 ING2 ZMYND8 SP140L PHF3

3.44e-0679976IPR019787
DomainPHD

KDM5B ING1 ING2 ZMYND8 SP140L PHF3

6.89e-0689976SM00249
DomainZnf_PHD

KDM5B ING1 ING2 ZMYND8 SP140L PHF3

7.84e-0691976IPR001965
DomainZF_PHD_2

KDM5B ING1 ING2 ZMYND8 SP140L PHF3

1.01e-0595976PS50016
DomainZF_PHD_1

KDM5B ING1 ING2 ZMYND8 SP140L PHF3

1.07e-0596976PS01359
DomainZnf_FYVE_PHD

KDM5B ING1 ING2 ZMYND8 SP140L PHF3

1.18e-04147976IPR011011
DomainActinin_actin-bd_CS

FLNB FLNC MACF1

2.23e-0423973IPR001589
DomainACTININ_2

FLNB FLNC MACF1

2.23e-0423973PS00020
DomainACTININ_1

FLNB FLNC MACF1

2.23e-0423973PS00019
DomainING

ING1 ING2

2.64e-045972SM01408
DomainING_N_histone_binding

ING1 ING2

2.64e-045972IPR024610
DomainING

ING1 ING2

2.64e-045972PF12998
DomainING_fam

ING1 ING2

2.64e-045972IPR028651
DomainLON

LONRF1 LONRF2

3.95e-046972SM00464
DomainZF_BED

ZBED4 ZBED6

3.95e-046972PS50808
Domainzf-BED

ZBED4 ZBED6

3.95e-046972PF02892
DomainELMO

ELMOD2 ELMO1

3.95e-046972PS51335
DomainLON_N

LONRF1 LONRF2

3.95e-046972PS51787
DomainELMO_CED12

ELMOD2 ELMO1

3.95e-046972PF04727
DomainLON_substr-bd_dom

LONRF1 LONRF2

3.95e-046972IPR003111
DomainLON_substr_bdg

LONRF1 LONRF2

3.95e-046972PF02190
DomainELMO_dom

ELMOD2 ELMO1

3.95e-046972IPR006816
Domain-

KDM5B UBE4B ING1 ING2 LONRF1 ZMYND8 SP140L PHF3 LONRF2

5.46e-044499793.30.40.10
DomainZnf_RING/FYVE/PHD

KDM5B UBE4B ING1 ING2 LONRF1 ZMYND8 SP140L PHF3 LONRF2

6.39e-04459979IPR013083
DomainHATC_C_dom

ZBED4 ZBED6

7.32e-048972IPR008906
DomainDimer_Tnp_hAT

ZBED4 ZBED6

7.32e-048972PF05699
DomainC2

UNC13B WWC2 PLCL2 PRKCD PLCL1

8.71e-04142975PS50004
Domain-

UNC13B WWC2 PLCL2 PRKCD PLCL1

1.05e-031489752.60.40.150
DomainIG_FLMN

FLNB FLNC

1.17e-0310972SM00557
DomainFilamin

FLNB FLNC

1.42e-0311972PF00630
DomainZnF_BED

ZBED4 ZBED6

1.42e-0311972SM00614
DomainFILAMIN_REPEAT

FLNB FLNC

1.42e-0311972PS50194
DomainFilamin/ABP280_rpt

FLNB FLNC

1.42e-0311972IPR001298
DomainFilamin/ABP280_repeat-like

FLNB FLNC

1.42e-0311972IPR017868
DomainC2_dom

UNC13B WWC2 PLCL2 PRKCD PLCL1

1.65e-03164975IPR000008
DomainZnf_BED

ZBED4 ZBED6

1.70e-0312972IPR003656
DomainPLipase_C_Pinositol-sp_Y

PLCL2 PLCL1

2.68e-0315972IPR001711
DomainEF-hand_like

PLCL2 PLCL1

2.68e-0315972PF09279
DomainPIPLC_Y_DOMAIN

PLCL2 PLCL1

2.68e-0315972PS50008
DomainPI-PLC_fam

PLCL2 PLCL1

2.68e-0315972IPR001192
DomainPLC_EF-hand-like

PLCL2 PLCL1

2.68e-0315972IPR015359
DomainPI-PLC-Y

PLCL2 PLCL1

2.68e-0315972PF00387
DomainPLCYc

PLCL2 PLCL1

2.68e-0315972SM00149
DomainC1_1

UNC13B CHN1 PRKCD

3.24e-0357973PF00130
DomainPH_DOMAIN

ADRM1 DOCK10 ELMO1 PLEKHA3 PLCL2 PLCL1

3.35e-03279976PS50003
DomainPI-PLC-X

PLCL2 PLCL1

3.87e-0318972PF00388
DomainPLCXc

PLCL2 PLCL1

3.87e-0318972SM00148
DomainPUA-like_domain

LONRF1 LONRF2

4.31e-0319972IPR015947
DomainPIPLC_X_DOMAIN

PLCL2 PLCL1

4.31e-0319972PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCL2 PLCL1

4.31e-0319972IPR000909
DomainZF_DAG_PE_1

UNC13B CHN1 PRKCD

4.50e-0364973PS00479
DomainZF_DAG_PE_2

UNC13B CHN1 PRKCD

4.50e-0364973PS50081
DomainC1

UNC13B CHN1 PRKCD

4.70e-0365973SM00109
DomainCH

FLNB FLNC MACF1

4.70e-0365973SM00033
DomainPE/DAG-bd

UNC13B CHN1 PRKCD

4.90e-0366973IPR002219
PathwayWP_17Q12_COPY_NUMBER_VARIATION_SYNDROME

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3C FBXO47 TBC1D3I TBC1D3G TBC1D3K

1.00e-0999689M46448
Pubmed

TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3I TBC1D3G TBC1D3K TBC1D3F

3.28e-25111021016863688
Pubmed

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

TBC1D3E TBC1D3 TBC1D3H TBC1D3D TBC1D3G TBC1D3F

8.64e-0874102616625196
Pubmed

PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.

TBC1D3 TBC1D3D TBC1D3F

9.78e-084102312359748
Pubmed

Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.

TBC1D3 TBC1D3D TBC1D3F

9.78e-08410238406013
Pubmed

The Tre2 (USP6) oncogene is a hominoid-specific gene.

TBC1D3 TBC1D3D TBC1D3C

2.44e-075102312604796
Pubmed

Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.

TBC1D3 TBC1D3D TBC1D3F

2.44e-07510238471161
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

UNC13B FLNB KDM5B OGT ERG OXR1 UBE4B LONRF1 ZMYND8 PIAS1 UBE2O PTPRK ADAMTS9 UBE3A MACF1 SMARCE1

1.05e-0612851021635914814
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UNC13B UBE4B DOCK10 USP19 ZBED4 PHF3 PLCL2 MACF1 CEP170B

3.31e-06407102912693553
Pubmed

USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1.

FLNB FLNC USP19

3.97e-0611102319015242
Pubmed

Phospholipase C-related but catalytically inactive protein acts as a positive regulator of insulin signalling in adipocytes.

PLCL2 PLCL1

8.52e-062102234859819
Pubmed

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome.

IL1B AIM2

8.52e-062102230755509
Pubmed

Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice.

PLCL2 PLCL1

8.52e-062102231589911
Pubmed

Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses.

TRPA1 IL1B

8.52e-062102236650454
Pubmed

A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha.

FLNB FLNC

8.52e-06210229694715
Pubmed

Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer.

ING1 ING2

8.52e-062102216465410
Pubmed

Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors.

PLCL2 PLCL1

8.52e-062102219996098
Pubmed

Identification and characterization of a new phospholipase C-like protein, PLC-L(2).

PLCL2 PLCL1

8.52e-062102210581172
Pubmed

Interleukin 1 beta-induced calcium signaling via TRPA1 channels promotes mitogen-activated protein kinase-dependent mesangial cell proliferation.

TRPA1 IL1B

8.52e-062102234143493
Pubmed

Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface.

PLCL2 PLCL1

8.52e-062102217301177
Pubmed

DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53.

ING1 ING2

8.52e-062102211481424
Pubmed

The limits of promiscuity: isoform-specific dimerization of filamins.

FLNB FLNC

8.52e-062102212525170
Pubmed

Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels.

PLCL2 PLCL1

8.52e-062102219553601
Pubmed

Genetic reduction of GABA(A) receptor gamma2 subunit expression potentiates the immobilizing action of isoflurane.

PLCL2 PLCL1

8.52e-062102220097266
Pubmed

Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex.

PLCL2 PLCL1

8.52e-062102217254016
Pubmed

Expression of novel ING variants is regulated by thyroid hormone in the Xenopus laevis tadpole.

ING1 ING2

8.52e-062102211600495
Pubmed

AIM2 Inflammasome Is Critical for dsDNA-Induced IL-1β Secretion in Human Dental Pulp Cells.

IL1B AIM2

8.52e-062102229178062
Pubmed

Yersinia pestis activates both IL-1β and IL-1 receptor antagonist to modulate lung inflammation during pneumonic plague.

IL1B AIM2

8.52e-062102225781467
Pubmed

Regulation of O-Linked N-Acetyl Glucosamine Transferase (OGT) through E6 Stimulation of the Ubiquitin Ligase Activity of E6AP.

OGT UBE3A

8.52e-062102234638625
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

MIER2 VRK1 OGT ERCC6 ARHGAP11A ADNP PIAS1 UBE2O PHF3 SMARCE1

1.25e-056081021036089195
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

OGT ING1 ING2 ZMYND8 PHF3 SMARCE1 CLP1

1.48e-05268102733640491
Pubmed

Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.

OGT ING1 ING2

2.29e-0519102322984288
Pubmed

Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.

OGT ING1 ING2

2.29e-0519102328554894
Pubmed

Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema.

IL1B AIM2

2.55e-053102236037355
Pubmed

Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice.

PLCL2 PLCL1

2.55e-053102223639135
Pubmed

ADAMTS9 activation by interleukin 1 beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes.

ADAMTS9 IL1B

2.55e-053102219052845
Pubmed

Cutting Edge: Cytosolic Receptor AIM2 Is Induced by Peroxisome Proliferator-activated Receptor γ following Mycobacterium tuberculosis Infection of Human Macrophages but Does Not Contribute to IL-1β Release.

IL1B AIM2

2.55e-053102238251918
Pubmed

Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome.

IL1B AIM2

2.55e-053102234006824
Pubmed

Diversity of human copy number variation and multicopy genes.

TBC1D3E TBC1D3G

2.55e-053102221030649
Pubmed

IL-1R-associated kinase-1 mediates protein kinase Cδ-induced IL-1β production in monocytes.

PRKCD IL1B

2.55e-053102221804018
Pubmed

Interleukin-1β induced nuclear factor-κB binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells.

ADAMTS9 IL1B

2.55e-053102225760020
Pubmed

Phospholipase C-related catalytically inactive protein, a novel microtubule-associated protein 1 light chain 3-binding protein, negatively regulates autophagosome formation.

PLCL2 PLCL1

2.55e-053102223399561
Pubmed

A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling.

ING1 ING2

2.55e-053102227305909
Pubmed

Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.

FLNB FLNC

2.55e-053102212393796
Pubmed

Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis.

VRK1 PRKCD

2.55e-053102221346188
Pubmed

Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.

FLNB FLNC

2.55e-053102211153914
Pubmed

Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation.

PLCL2 PLCL1

2.55e-053102221757756
Pubmed

Filamins as integrators of cell mechanics and signalling.

FLNB FLNC

2.55e-053102211252955
Pubmed

Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits.

CHN1 EPHA4

2.55e-053102224623763
Pubmed

EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin.

CHN1 EPHA4

2.55e-053102217785182
Pubmed

IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation.

UBE3A IL1B

2.55e-053102237474493
Pubmed

The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing.

ING1 ING2

2.55e-053102217929852
Pubmed

Enhanced IL-1β Release Following NLRP3 and AIM2 Inflammasome Stimulation Is Linked to mtROS in Airway Macrophages in Pulmonary Fibrosis.

IL1B AIM2

2.55e-053102234220810
Pubmed

Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase.

PLCL2 PLCL1

2.55e-053102224945349
Pubmed

ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B.

FLNB KDM5B

2.55e-053102238880187
Pubmed

Post-translational control of IL-1β via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53.

UBE3A IL1B

2.55e-053102223935506
Pubmed

Significance of expression of AIM2, IL-1β, and IL-18 in plasma of patients with acute cerebral infarction.

IL1B AIM2

2.55e-053102233678651
Pubmed

The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions.

ERCC6 PARP2

2.55e-053102237326017
Pubmed

Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by β-Adrenergic Receptors in Brown Adipocytes.

PLCL2 PLCL1

2.55e-053102226706316
Pubmed

Cytokine secretion and pyroptosis of cholesteatoma keratinocytes mediated by AIM2 inflammasomes in response to cytoplasmic DNA.

IL1B AIM2

2.55e-053102233760111
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

OGT ERG ZMYND8 ADNP PIAS1 SMARCE1

4.86e-05220102635785414
Pubmed

The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.

FLNB FLNC

5.09e-054102211739414
Pubmed

Structural interaction and functional regulation of polycystin-2 by filamin.

FLNB FLNC

5.09e-054102222802962
Pubmed

Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling.

CHN1 EPHA4

5.09e-054102217719550
Pubmed

TRIM5α is a SUMO substrate.

PIAS1 SUMO2

5.09e-054102225880753
Pubmed

Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling.

PLCL2 PLCL1

5.09e-054102228341745
Pubmed

AIM2 mediates inflammation-associated renal damage in hepatitis B virus-associated glomerulonephritis by regulating caspase-1, IL-1β, and IL-18.

IL1B AIM2

5.09e-054102224701032
Pubmed

HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation.

ING1 ING2

5.09e-054102220621832
Pubmed

Functional proteomics mapping of a human signaling pathway.

FLNB FLNC ERCC6 ZMYND8 PIAS1 UBE3A PLCL2 MACF1 SMARCE1

6.27e-05591102915231748
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

OGT UBE4B ZMYND8 ADNP UPF2 UBE3A PRKCD

6.82e-05341102732971831
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

KDM5B FLNC VRK1 OGT ZMYND8 ADNP RAB10 ZBED4 UPF2 MACF1 SMARCE1 CLP1

7.98e-0510821021238697112
Pubmed

PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein.

PIAS1 SUMO2

8.47e-055102216600910
Pubmed

Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity.

FLNB FLNC

8.47e-055102212006559
Pubmed

The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.

IL1B AIM2

8.47e-055102226655906
Pubmed

Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.

FLNB FLNC

8.47e-055102217360453
Pubmed

IL-32θ negatively regulates IL-1β production through its interaction with PKCδ and the inhibition of PU.1 phosphorylation.

PRKCD IL1B

8.47e-055102224996056
Pubmed

alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits.

CHN1 EPHA4

8.47e-055102217785183
Pubmed

HIV infection of T cells: actin-in and actin-out.

FLNB FLNC

8.47e-055102219366992
Pubmed

Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome.

CHN1 EPHA4

8.47e-055102228346224
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

UNC13B FLNB ERG USP19 ELAPOR1 SLC4A10 CLP1

1.15e-04371102715747579
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

OGT ERCC6 PARP2 ZMYND8 PIAS1 RAB10 ZBED6 PHF3 ELAPOR1 ANKRD11 MACF1 SMARCE1 CLP1 CEP170B

1.21e-0414971021431527615
Pubmed

Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.

OGT UBE2O

1.27e-046102224703950
Pubmed

MrgprA3-expressing pruriceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel.

TRPA1 PRKCD

1.27e-046102236961815
Pubmed

Role of inflammasomes in host defense against Citrobacter rodentium infection.

IL1B AIM2

1.27e-046102222461621
Pubmed

The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.

PIAS1 SUMO2

1.27e-046102222406621
Pubmed

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage.

PIAS1 SUMO2

1.27e-046102222661230
Pubmed

NLRP3/ASC/Caspase-1 axis and serine protease activity are involved in neutrophil IL-1β processing during Streptococcus pneumoniae infection.

IL1B AIM2

1.27e-046102230982580
Pubmed

GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice.

PLCL2 PLCL1

1.27e-046102220412381
Pubmed

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

PIAS1 SUMO2

1.27e-046102220016594
Pubmed

α2-chimaerin is required for Eph receptor-class-specific spinal motor axon guidance and coordinate activation of antagonistic muscles.

CHN1 EPHA4

1.27e-046102225673830
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

VRK1 OGT UBE4B ADRM1 PIAS1 USP19 RAB10 ZBED4 UPF2 UBE3A PLEKHA3 ANKRD11 PGP

1.37e-0413271021332694731
Pubmed

Downregulation of HERC5 E3 ligase attenuates the ubiquitination of CtBP1 to inhibit apoptosis in colorectal cancer cells.

PIAS1 USP19 UBE3A

1.77e-0437102334147029
Pubmed

The developing mouse coronal suture at single-cell resolution.

ERG CRABP2 EPHA4

1.77e-0437102334376651
Pubmed

A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.

PIAS1 PPARGC1B

1.77e-047102222969086
Pubmed

Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae.

IL1B AIM2

1.77e-047102230794604
Pubmed

Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition.

PLCL2 PLCL1

1.77e-047102216754670
Pubmed

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction.

IL1B AIM2

1.77e-047102222286270
Pubmed

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.

ING1 ING2

1.77e-047102216728974
Pubmed

Phospho-regulated SUMO interaction modules connect the SUMO system to CK2 signaling.

PIAS1 SUMO2

1.77e-047102219217413
Pubmed

The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.

FLNB FLNC

1.77e-047102216076904
Pubmed

Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes.

IL1B AIM2

1.77e-047102232181339
InteractionHDAC1 interactions

MIER2 FLNB KDM5B OGT ERCC6 ING1 ING2 ADRM1 PARP2 ZMYND8 ADNP USP19 SMARCE1 SUMO2 DCTN4 CLP1 SNX9 AIM2

6.68e-0611089918int:HDAC1
CytobandEnsembl 112 genes in cytogenetic band chr17q12

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C FBXO47 TBC1D3I TBC1D3G TBC1D3K TBC1D3F

4.00e-1414910211chr17q12
Cytoband17q12

TBC1D3 TBC1D3H TBC1D3C FBXO47 TBC1D3F

2.97e-0699102517q12
GeneFamilyPHD finger proteins

KDM5B ING1 ING2 ZMYND8 SP140L PHF3

5.18e-079060688
GeneFamilyZinc fingers BED-type|Pseudoautosomal region 1

ZBED4 ZBED6

1.61e-04660264
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCL2 PLCL1

1.79e-0319602832
GeneFamilyZinc fingers MYND-type

ZMYND8 USP19

2.18e-032160287
CoexpressionGSE4590_SMALL_VS_VPREB_POS_LARGE_PRE_BCELL_UP

KDM5B OGT ZMYND8 DOCK10 PLEKHA3 DNAI4 AIM2

3.80e-061681007M6874
CoexpressionNAKAYA_B_CELL_FLUARIX_FLUVIRIN_AGE_18_50YO_7DY_DN

OGT OXR1 ING2 ELMO1 UBE2O UBE3A ANKRD11 ZNF264

1.74e-052941008M41112
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

FLNB KDM5B VRK1 OGT ZMYND8 ARHGAP11A ADNP UPF2 PTPRK UBE3A PHF3 MACF1 EPHA4

2.27e-0585610013M4500
CoexpressionAtlasMesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3G TBC1D3K TBC1D3F

1.03e-08901008PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlasEndoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TRPA1 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3G TBC1D3K TBC1D3F

7.50e-072131009PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlasEndoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TRPA1 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3G TBC1D3K TBC1D3F

7.50e-072131009PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlasDE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TRPA1 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3G TBC1D3K TBC1D3F

2.16e-062421009PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D CRABP2 TBC1D3C ADAMTS9 TBC1D3G TBC1D3K TBC1D3F

2.74e-0632010010PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

FLNC TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3G TBC1D3K TBC1D3F

7.28e-062811009PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05

FLNC TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3G TBC1D3K TBC1D3F

7.28e-062811009PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05

FLNB FLNC TBC1D3 TRPA1 TBC1D3H TBC1D3L TBC1D3D ELMOD2 LONRF1 CRABP2 TBC1D3C ADAMTS9 TBC1D3G TCEAL9 TBC1D3K EPHA4 TBC1D3F

2.55e-05115310017PCBC_ratio_MESO-5_vs_SC_cfr-2X-p05
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#4_top-relative-expression-ranked_200

FLNC GUCY1A2 AIM2

1.27e-04211003gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k4_200
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

FLNB ERG OXR1 ELMO1 ADAMTS9 IRAK3 EPHA4

3.14e-07193102701c2df9206f1527c578e808978e58196c35e72f5
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

FLNB ERG OXR1 ELMO1 ADAMTS9 IRAK3 EPHA4

3.14e-0719310272531266bc57339d4e2b22a88817008e32b8c1598
ToppCellfacs-Lung-nan-3m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK10 MPEG1 PKD1L2 PRKCD IL1B AIM2

1.61e-0615610263f0b9e35d4da85c90759b930052e5b9c3cde9b15
ToppCellfacs-Lung-nan-3m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK10 MPEG1 PKD1L2 PRKCD IL1B AIM2

1.61e-06156102669e6e8810d1738a66c9821910f41498931cf30cc
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK10 MPEG1 PHF3 ANKRD11 MACF1 SNX9

4.19e-0618410261154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellRA-10._Endothelium_II|World / Chamber and Cluster_Paper

FLNB ERG OXR1 ELMO1 ADAMTS9 IRAK3

4.89e-06189102675c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

FLNB ERG OXR1 ELMO1 ADAMTS9 IRAK3

4.89e-061891026c81787a8c662db5d7814c583dd64562857629e81
ToppCellLV-10._Endothelium_II|LV / Chamber and Cluster_Paper

FLNB ERG ELMO1 ADAMTS9 IRAK3 EPHA4

5.68e-061941026b6cc849fa08599bff9839ef382d190cc964e273e
ToppCellfacs-MAT-Fat-24m-Myeloid-macrophage|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPEG1 PKD1L2 PRKCD IL1B AIM2

2.89e-051551025d0c1608f8f6b6f4174e51d610501c707cba5e015
ToppCell356C-Myeloid-Dendritic-pDC|356C / Donor, Lineage, Cell class and subclass (all cells)

FLNB ZNF215 ELMO1 PHEX LONRF2

2.98e-051561025d9d87368e43b24952e70f31f38425e15b716ff5b
ToppCellfacs-Lung-3m-Hematologic-myeloid-intermediate_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MPEG1 PKD1L2 PRKCD IL1B AIM2

3.17e-051581025b35bab2b93d0af821bfae18a358eb7dddaf3860f
ToppCellfacs-Lung-3m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MPEG1 PKD1L2 PRKCD IL1B AIM2

3.17e-0515810257bd4a64a610eb1cbcd3d07ea5258a55107cf6c00
ToppCellfacs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEMGN GC NXPE2 ABCG4 UBE2O

3.58e-051621025860ebf2390b4ad86475ad54717cbefcf61cd3b2a
ToppCellfacs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HEMGN GC NXPE2 ABCG4 UBE2O

3.58e-05162102514e9f8aaba308619eb9da90796c336e76cedac1f
ToppCell356C-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

FLNB KDM5B ZNF215 PHEX LONRF2

3.68e-051631025ae9c5eb19657ea94b7f2357cbc8679acd697b8fe
ToppCell356C-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FLNB KDM5B ZNF215 PHEX LONRF2

3.79e-051641025fed26f4ac36a2b0722bc7b9f91659c5e0cf4d53a
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK10 PLCL2 GPR171 PLCL1 KIR2DL4

4.37e-0516910258caf7996796a2e2716e3855de855c903d6126bf2
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DOCK10 MPEG1 PPARGC1B PLCL2 AIM2

4.37e-0516910253e40ae0b23a962e0f15908872dec63f51c5b8b83
ToppCellAT1-AT2_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

UNC13B FLNB WWC2 ADAMTS9 PLCL1

5.16e-051751025bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCellT_cells-Tph_and_Tfh|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

ELMO1 PHEX ELAPOR1 SNX9 AIM2

5.30e-05176102556c055488e34605d32562571a2fee621b47c9441
ToppCellfacs-Lung-EPCAM-18m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VRK1 DOCK10 MPEG1 PRKCD GPR171

5.45e-0517710257bc92314b22a876296a4e2db51e7fb0fdfd69379
ToppCellfacs-Lung-3m-Hematologic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK10 MPEG1 PRKCD GPR171 IL1B

5.45e-051771025a8a7b135d86701ab9acac8273061debf8cce79a0
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLNB ERG ELMO1 ADAMTS9 EPHA4

5.75e-0517910251ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

FLNB ERG ELMO1 ADAMTS9 EPHA4

5.75e-0517910252a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPA1 CHN1 PPARGC1B GUCY1A2 PLCL1

5.90e-05180102578fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCell3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC168 ZBED4 PLCL2 SLC4A10 GPR171

6.38e-051831025f079179f2984def91ddf0b33d7949d5ecdbd380d
ToppCellCOVID-19-Heart-EC_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERG CHN1 ELMO1 ADAMTS9 EPHA4

6.38e-051831025ff95382cfed592190d0636d2b750328471f82e0d
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FLNB FLNC ERG ELMO1 ADAMTS9

6.38e-051831025bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCell3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC168 ZBED4 PLCL2 SLC4A10 GPR171

6.38e-05183102549e8ee16e4f677f9f649e2a2faf1b9b16c5a27e7
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPA1 CHN1 PPARGC1B GUCY1A2 PLCL1

6.55e-051841025f4344f3c407b2d4d703fe56e43d84dbfe60ba833
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADNP CHN1 PLEKHA3 GPR171 EPHA4

6.72e-051851025e34473eea3a58c041183a4f52137366cd9489495
ToppCellControl-Lymphoid-ILC_A|Lymphoid / Disease state, Lineage and Cell class

PLCL2 IRAK3 KIR2DL4 TBC1D3K EPHA4

6.72e-051851025520795866d44def5be3910ce8e728045c716a24d
ToppCellCOVID-19-Endothelial_cells-Systemic_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

FLNB ERG CHN1 ADAMTS9 EPHA4

6.72e-051851025f5e14181f45c37d13ee9e017a4c8bc248c353676
ToppCellLPS-IL1RA-Myeloid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK10 MPEG1 IRAK3 IL1B AIM2

6.72e-0518510259b5fd87ea9d05e051ff1251578ecfbe5e8652853
ToppCellfacs-Heart-LA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHN1 PPARGC1B GUCY1A2 PTPRK PLCL1

7.07e-051871025a12f383b02b07af32cc53a154685df8dba8fbd3f
ToppCellfacs-Heart-LA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHN1 PPARGC1B GUCY1A2 PTPRK PLCL1

7.07e-051871025c40c152fa14e6afc9188549534b64ccbaded56b3
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

FLNB ERG ELMO1 ADAMTS9 EPHA4

7.07e-05187102540ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellCOVID_vent-Myeloid-Monocytic-SC_&_Eosinophil|COVID_vent / Disease condition, Lineage, Cell class and subclass

KDM5B ERG HEMGN IL1B TCEAL9

7.43e-0518910252157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERG CHN1 ELMO1 ADAMTS9 EPHA4

7.43e-0518910257346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCelltumor_Lung-Fibroblasts-Pericytes|Fibroblasts / Location, Cell class and cell subclass

ANKRD62 CHN1 GUCY1A2 ADAMTS9 PLCL1

7.43e-0518910259c407b17d7945e81e1ae6c18452f5d20fb09d563
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ERG CHN1 OVCH1 ELMO1 EPHA4

7.43e-05189102512b6f1c3bf526b90e112374bf937701f645c5780
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

OGT ZBED4 PHF3 MACF1 GPR171

7.62e-05190102591ba66d4b56c59523485b17738e93f14bb00afa4
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|World / Sample and Cell Type and Tumor Cluster (all cells)

DOCK10 RHOQ PLCL2 IRAK3 PLCL1

7.81e-0519110253b59bfc6c106ae8a3fbcd4a74bd128c485724921
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK10 MPEG1 ELMO1 GPR171 IL1B

7.81e-051911025c72e62cf5b45c04ee5e7719db31f917c4f76b1e4
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

FLNB ERG CHN1 ELMO1 IRAK3

8.00e-051921025c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

ERG CHN1 ELMO1 ADAMTS9 EPHA4

8.00e-05192102527ff3621e177e7932dd44dd6baa81551ea75a874
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VRK1 DOCK10 MPEG1 PRKCD GPR171

8.00e-0519210258b4bbbadeac70f65378697120c754f10501b5651
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

OXR1 PTPRK ANKRD11 MACF1 PLCL1

8.00e-051921025e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK10 CHN1 ELMO1 MACF1 IRAK3

8.40e-051941025b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellRV-09._Endothelium_I|RV / Chamber and Cluster_Paper

FLNB ERG ELMO1 ADAMTS9 EPHA4

8.40e-0519410257b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK10 MPEG1 ELMO1 IRAK3 IL1B

8.40e-051941025badefcec2af86cbcd97305f4843e84db0f3ebc66
ToppCellCOVID-19-kidney-Proliferating_T_cell|kidney / Disease (COVID-19 only), tissue and cell type

VRK1 DOCK10 HEMGN ARHGAP11A GPR171

8.61e-0519510257e05e56f8d0a7a052830c7db12b10dace7d10760
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLNB ERG CHN1 ELMO1 ADAMTS9

8.61e-051951025818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCellILEUM-non-inflamed-(3)_moDC|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

MPEG1 ELMO1 RHOQ IRAK3 IL1B

8.82e-051961025e10f01172fd076d6892906853f9375d4c3058951
ToppCellT_cells-Treg_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

CCDC122 CHN1 ELAPOR1 PLCL1 SNX9

9.03e-051971025ec9398ae3577f61d6b1e6aba50ef4261aaaa7610
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-NK-ILC-T_NK-ILC|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK10 HEMGN GPR171 KIR2DL4 EPHA4

9.03e-0519710259791923feefbd78810242113ad2a08ce4c2bb4f2
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_naive-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MIER2 MPEG1 ZBED6 IRAK3 IL1B

9.03e-0519710254a6eff66a17c5e89bda61d887b736f5c62b93bd7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERG CHN1 ELMO1 IRAK3 EPHA4

9.25e-051981025451003a21162eeae90739fdb502bb50b362d80c8
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

OXR1 CHN1 UBE3A SLC4A10 EPHA4

9.25e-0519810258ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ERG CHN1 ELMO1 IRAK3 EPHA4

9.25e-051981025440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCellSepsis-ICU-SEP-Myeloid-pDC|ICU-SEP / Disease, condition lineage and cell class

FLNB PHEX MINAR1 SNX9 CEP170B

9.25e-051981025fe8a68bff8c1b9566eee4bfcab564f206a20ae7b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK10 MPEG1 ELMO1 IRAK3 IL1B

9.25e-051981025623f9d64c9e800d2d7f623392bf2f22b563f0249
ToppCellcontrol-HLA-DR+_CD83+_Monocyte|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MPEG1 RHOQ RAB10 PRKCD IL1B

9.47e-051991025f1b370d2869ad29c9d8ff41fdcc486fffa781ee2
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FLNB FLNC ERG ADAMTS9 EPHA4

9.47e-0519910256a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MPEG1 MAP10 LYPD3 CLP1 SNX9

9.69e-05200102588d713dfc792e7609bf7ecfb28f87cb748088570
ToppCellSepsis-URO-Lymphocyte-T/NK-CD4+_Tem|URO / Disease, condition lineage and cell class

TMEM67 CCDC168 CHN1 ELAPOR1 GPR171

9.69e-0520010258b7bfe6411de9528603481f6e5612cbbb8471cf6
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Intermediate|3m / Sample Type, Dataset, Time_group, and Cell type.

KDM5B PIAS1 ELAPOR1 ANKRD11 EPHA4

9.69e-052001025cbd0b9188a94778ffa539912aeb2a4378f0ab88f
Diseasemyofibrillar myopathy 5 (implicated_via_orthology)

FLNB FLNC

2.82e-053912DOID:0080096 (implicated_via_orthology)
Diseasedistal muscular dystrophy 4 (implicated_via_orthology)

FLNB FLNC

2.82e-053912DOID:0111190 (implicated_via_orthology)
Diseaseasthma, Eczema, allergic rhinitis

PTPRK SMARCE1 PLCL1 IL1B

5.46e-04121914EFO_0005854, HP_0000964, MONDO_0004979
DiseaseSeizures

OXR1 FKTN MACF1 PRKCD IL1B

5.84e-04218915C0036572
Diseaseuveitis (is_implicated_in)

GC IL1B

7.18e-0413912DOID:13141 (is_implicated_in)
DiseaseCongenital pontocerebellar hypoplasia

VRK1 CLP1

7.18e-0413912C0266468
DiseaseMetabolic Bone Disorder

GC ANKRD11

8.36e-0414912C0005944
DiseaseOsteopenia

GC ANKRD11

9.62e-0415912C0029453
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5B ZMYND8

1.10e-0316912DOID:0050888 (implicated_via_orthology)
DiseasePontoneocerebellar hypoplasia

VRK1 CLP1

1.10e-0316912cv:C1261175
DiseaseCraniofacial Abnormalities

ERCC6 PHEX UBE3A MSL3

1.41e-03156914C0376634
Diseaseosteoporosis (implicated_via_orthology)

IRAK3 IL1B

1.55e-0319912DOID:11476 (implicated_via_orthology)
Diseaseresponse to methotrexate, neurotoxicity

MACF1 PLCL1

1.55e-0319912EFO_0011057, GO_0031427
DiseaseCCL4 measurement

TBC1D3 TBC1D3F

1.72e-0320912EFO_0004751
DiseaseMalignant neoplasm of breast

FLNB ERCC6 ARHGAP11A PPARGC1B GUCY1A2 FKTN ELAPOR1 ANKRD30A MACF1 IL1B

1.75e-0310749110C0006142
Diseasealcohol drinking

LONRF1 PLCL1 LONRF2

2.03e-0381913EFO_0004329
DiseaseEpilepsy, Cryptogenic

UBE3A SLC4A10 ANKRD11

2.11e-0382913C0086237
DiseaseAwakening Epilepsy

UBE3A SLC4A10 ANKRD11

2.11e-0382913C0751111
DiseaseAura

UBE3A SLC4A10 ANKRD11

2.11e-0382913C0236018
Diseaseplatelet component distribution width

ZMYND8 DOCK10 HEMGN ELMO1 RAB10 UBE2O MACF1 SNX9

2.33e-03755918EFO_0007984

Protein segments in the cluster

PeptideGeneStartEntry
PAAKKKATMQGDREQ

ADNP

1011

Q9H2P0
GLCAMAEKKSSPEKN

ABCG4

331

Q9H172
KNINPEKDASFKICM

ELMOD2

81

Q8IZ81
DCPHMKEKGALKQNK

ELMO1

621

Q92556
EKGDPVKMSNGNDKV

ANKRD11

1541

Q6UB99
VKMSNGNDKVAPSKD

ANKRD11

1546

Q6UB99
MGTEKESPEPDCQKQ

ACBD4

1

Q8NC06
VRNEDTMKCKEGDKV

AIM2

296

O14862
QNIDGKELCKMTKDD

ERG

161

P11308
DVCVPKATHQKEMDK

ANKRD30A

936

Q9BXX3
CESSQPQVEEKMKKC

ANKRD62

291

A6NC57
IEFDDCSPGKMKIKD

CEP170B

271

Q9Y4F5
EKCQDGIMKKEGKDN

ERCC6

1351

Q03468
GNKCDMDDKRVVPKG

RAB10

121

P61026
ENKMVCEQKLLKGEG

CRABP2

91

P29373
QKVKCKMEDDAVPAA

IQCK

266

Q8N0W5
KPSGEMDEVGVQKCK

MPEG1

21

Q2M385
KANKDRTEDKQDGMP

PARP2

56

Q9UGN5
ADGPKQMKCSFQDLD

IL1B

26

P01584
LKEMVKSKAECDNVG

MAP10

246

Q9P2G4
DEANQPFCAVKMKEA

PRKCD

21

Q05655
KLKKQGETPNEVCMF

LONRF1

446

Q17RB8
NAGEFLDMKDQSCKP

ELAPOR1

96

Q6UXG2
GSCVNNSEEKDVPKM

EPHA4

231

P54764
KVKMDCQETPEGYKV

FLNB

2426

O75369
NNQESDCVSKKKMVP

PGP

291

A6NDG6
AIEGPSEAKMSCKDN

FLNC

1386

Q14315
MIPIKDIKEKSNVGC

GPR171

151

O14626
PAEKNVDLCKEMVDG

MSL3

246

Q8N5Y2
GCPTPKCENEKEMKS

KDM5B

261

Q9UGL1
PECNSVKKEAQKVMC

LONRF2

296

Q1L5Z9
KKPESKRNEEACNMP

IRAK3

521

Q9Y616
PVMSDRECQKTEQGK

PRSS37

156

A4D1T9
PKCRGDNEKTMDKST

ING2

256

Q9H160
NSSKICQDMKEPEDN

HEMGN

186

Q9BXL5
CVQKADDGCSPNKMK

LYPD3

36

O95274
DDGCSPNKMKTVKCA

LYPD3

41

O95274
MGVNQAPEKLDKQCE

MACF1

3796

Q9UPN3
QEPSGMNAEGKSKDK

PKD1L2

546

Q7Z442
CSKKKDAAVMNQEPA

KIR2DL4

266

Q99706
KENMPCGETAEFKQK

OXR1

466

Q8N573
NMPHDDNNKCKEEGV

ADAMTS9

441

Q9P2N4
GDKQMKNSNFPAEVK

DOCK10

1641

Q96BY6
MSDNKERKSQGFPKE

CCDC122

1

Q5T0U0
TCKDEKGKQEMETGQ

LINC00305

31

Q7Z4B0
ENMGFQCLKIESKDP

FKTN

131

O75072
GAPKNKDVQCDKIIM

DNAI4

296

Q5VTH9
KIQMAVCSKPGSAQK

FBXO47

196

Q5MNV8
KEPGKMDQEAQEQGK

CCDC168

4191

Q8NDH2
QCSKMVPNDCKPDLK

CHN1

246

P15882
ENMPSAEAKLKKNRC

DCTN4

56

Q9UJW0
KNEPEDTEDKEGCQM

ZMYND8

611

Q9ULU4
EGCQMDKEPSAVKKK

ZMYND8

621

Q9ULU4
DSLPANKCKKEIMVG

MIER2

186

Q8N344
NKCKKEIMVGPQFQA

MIER2

191

Q8N344
NESKADCLDMDPKAP

PTPRK

436

Q15262
VKIVKMKCPDGGDNA

OGT

751

O15294
MEEKDSLPNNKEKDC

UPF2

11

Q9HAU5
ICKKCPENMKGVTED

TMEM67

96

Q5HYA8
PATLFKDKMKCTVNN

MINAR1

61

Q9UPX6
KPEASGSENKDKVME

GUCY1A2

391

P33402
IKSGPKEQKSMSCEE

ARHGAP11A

896

Q6P4F7
NDMKEKPICVEQGQK

RHOQ

136

P17081
EQKCEAVGKFTKAMD

SNX9

396

Q9Y5X1
ANKGEEKKDDENIPM

SMARCE1

326

Q969G3
SENIKKNCQIGMKTP

NXPE2

311

Q96DL1
CPKCRGENEKTMDKA

ING1

396

Q9UK53
LMEDDGKQNKRVCGK

OVCH1

361

Q7RTY7
IFDPEHKKVCQDMKQ

PLCL2

416

Q9UPR0
PCVKADSTQDKKAPM

PPARGC1B

191

Q86YN6
KAGCSPAVQMKIKEL

PIAS1

46

O75925
SQPKTMGHQDKKDLC

TBC1D3L

246

B9A6J9
AQEKQSPMKKFRECS

SLC35F4

221

A4IF30
PEARKESDQACGKMD

SP140L

181

Q9H930
MKCNRPSVKVEDKDF

ARNTL

251

O00327
MQNNAKPEQKEGDTK

ADRM1

381

Q16186
MGEEANDDKKPTTKF

CLP1

1

Q92989
SQPKTMGHQDKKDLC

TBC1D3H

246

P0C7X1
CDIFDPEQKKVAQDM

PLCL1

386

Q15111
RNPGKDDCAKEEMAV

USP19

251

O94966
KMCLDNGAQIDPVEK

TRPA1

256

O75762
SKQMPCKKNEENEDS

WWC2

826

Q6AWC2
KGAPNNSCSEIKMNK

UBE3A

101

Q05086
SQPKTMGHQDKKDLC

TBC1D3F

246

A6NER0
DPEALQKMAKCAVQD

SMRP1

56

Q8NCR6
RVGIEEKKAPKMCSQ

UBE4B

436

O95155
EKKAPKMCSQPAVSQ

UBE4B

441

O95155
DIGKKQSEPNSMDKN

SLC4A10

241

Q6U841
PEKNCAQGEGSMAKK

UBE2O

371

Q9C0C9
NKDVCDPGNTKVMDK

GC

331

P02774
GEKKNEALMECKAKP

PHF3

266

Q92576
SCMNEKAIEKADAKP

PHEX

141

P78562
MADEKPKEGVKTENN

SUMO2

1

P61956
GQAEKEAACEPKEMK

UNC13B

321

O14795
MKSCQKMEGKPENES

TCEAL9

1

Q9UHQ7
SQPKTMGHQDKKDLC

TBC1D3E

246

A0A087X179
NIASLMDKCFPEKNK

VRK1

281

Q99986
EECVKIANAKFKPEM

PLEKHA3

171

Q9HB20
GKDPMIQEEENNFKC

ZNF264

191

O43296
KMVAEGVNKEAKQPA

ZBED6

46

P86452
PCKDSALQMGSIKEK

ZNF215

136

Q9UL58
SQPKTMGHQDKKDLC

TBC1D3D

246

A0A087WVF3
SQPKTMGHQDKKDLC

TBC1D3G

246

Q6DHY5
SQPKTMGHQDKKDLC

TBC1D3

246

Q8IZP1
SQPKTMGHQDKKDLC

TBC1D3K

246

A0A087X1G2
SQPKTMGHQDKKDLC

TBC1D3I

246

A0A087WXS9
SQPKTMGHQDKKDLC

TBC1D3C

246

Q6IPX1
MENNLKTCPKEDGDF

ZBED4

1

O75132
PQSNKFVKCADMKDR

KLHL38

496

Q2WGJ6