Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium ion binding

SCN2A SCN3A SCN8A

3.89e-0514973GO:0031402
GeneOntologyMolecularFunctionSUMO ligase activity

RANBP2 RGPD8 RGPD3

1.19e-0420973GO:0061665
GeneOntologyMolecularFunctioncytoskeletal anchor activity

ANK2 ANK3 MAP1A

2.09e-0424973GO:0008093
GeneOntologyMolecularFunctionintegrin binding involved in cell-matrix adhesion

ITGB1 SVEP1

2.31e-045972GO:0098640
GeneOntologyMolecularFunctioncytoskeletal protein binding

ANK2 ANK3 MAP1A MAP1B PSG6 SORBS1 SAXO1 ITGB1 FARP2 ALMS1 LMO7 MACO1 DLG1 PSG8 DNAI7

2.59e-0410999715GO:0008092
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN2A SCN3A SCN8A

2.66e-0426973GO:0005248
GeneOntologyMolecularFunctionalkali metal ion binding

SCN2A SCN3A SCN8A

2.66e-0426973GO:0031420
GeneOntologyMolecularFunctionSUMO transferase activity

RANBP2 RGPD8 RGPD3

7.06e-0436973GO:0019789
GeneOntologyMolecularFunctioncell-matrix adhesion mediator activity

ITGB1 SVEP1

8.22e-049972GO:0098634
GeneOntologyMolecularFunctionphosphorylation-dependent protein binding

ANK2 ANK3

1.02e-0310972GO:0140031
GeneOntologyMolecularFunctionactinin binding

ITGB1 ALMS1 LMO7

1.19e-0343973GO:0042805
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RANBP2 RGPD8 RGPD3

1.85e-0350973GO:0003755
GeneOntologyMolecularFunctiongranulocyte colony-stimulating factor receptor binding

PSG6 PSG8

2.05e-0314972GO:0005130
GeneOntologyMolecularFunctionsodium channel activity

SCN2A SCN3A SCN8A

2.07e-0352973GO:0005272
GeneOntologyMolecularFunctioncis-trans isomerase activity

RANBP2 RGPD8 RGPD3

2.18e-0353973GO:0016859
GeneOntologyBiologicalProcessmembrane depolarization during action potential

ANK2 ANK3 SCN2A SCN3A SCN8A

7.33e-0736985GO:0086010
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RANBP2 RGPD8 RGPD3 RGPD5

2.19e-0620984GO:0006607
GeneOntologyBiologicalProcesscardiac muscle cell action potential

ANK2 ANK3 SCN2A SCN3A SCN8A DLG1

3.65e-0687986GO:0086001
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RANBP2 RGPD8 RGPD3

8.56e-069983GO:0033133
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

ANK2 SCN2A SCN3A SCN8A DLG1

1.14e-0562985GO:0086002
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RANBP2 RGPD8 RGPD3

1.22e-0510983GO:1903301
GeneOntologyBiologicalProcessregulation of glucokinase activity

RANBP2 RGPD8 RGPD3

2.87e-0513983GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RANBP2 RGPD8 RGPD3

3.64e-0514983GO:1903299
GeneOntologyBiologicalProcesscirculatory system development

ANK2 PSG6 HIPK1 UNC5B SPEG NACA E2F7 EYA1 RB1CC1 ITGB1 SVEP1 MET C2CD3 PTPRB CD34 VCAN HGS LRP2 PSG8

4.20e-0514429819GO:0072359
GeneOntologyBiologicalProcessnegative regulation of lymphocyte mediated immunity

PSG6 SVEP1 PSG8 CD96 NCKAP1L

4.73e-0583985GO:0002707
GeneOntologyBiologicalProcesscardiac muscle cell contraction

ANK2 SCN2A SCN3A SCN8A DLG1

8.16e-0593985GO:0086003
GeneOntologyBiologicalProcessnegative regulation of leukocyte mediated immunity

PSG6 SVEP1 PSG8 CD96 NCKAP1L

9.49e-0596985GO:0002704
GeneOntologyBiologicalProcessregulation of cytokinesis

AHCTF1 E2F7 BIRC6 KLHL13 ZFYVE26

1.10e-0499985GO:0032465
GeneOntologyBiologicalProcesscardiac muscle contraction

ANK2 MET SCN2A SCN3A SCN8A DLG1

1.47e-04167986GO:0060048
GeneOntologyBiologicalProcesscell-cell junction organization

ANK2 PSG6 HIPK1 ITGB1 SVEP1 DLG1 PSG8

1.73e-04246987GO:0045216
GeneOntologyBiologicalProcessprotein localization to organelle

RANBP2 ANK2 RGPD8 MAP1A NACA SH3BP4 ESCO2 C2CD3 SLF2 RGPD3 HGS LRP2 DLG1 RIPOR1 RGPD5

1.90e-0410919815GO:0033365
GeneOntologyBiologicalProcesspositive regulation of vasculogenesis

PSG6 CD34 PSG8

1.96e-0424983GO:2001214
GeneOntologyBiologicalProcessnegative regulation of guanyl-nucleotide exchange factor activity

MET RIPOR1

2.21e-045982GO:1905098
GeneOntologyBiologicalProcessestablishment or maintenance of cell polarity

ANK3 MAP1B EYA1 ITGB1 DLG1 PHLDB2 NCKAP1L

2.27e-04257987GO:0007163
GeneOntologyBiologicalProcessregulation of potassium ion transmembrane transporter activity

ANK2 ANK3 ITGB1 DLG1

2.30e-0463984GO:1901016
GeneOntologyBiologicalProcessneuronal action potential

ANK3 SCN2A SCN3A SCN8A

2.30e-0463984GO:0019228
GeneOntologyBiologicalProcessnegative regulation of Rho protein signal transduction

ITGB1 MET RIPOR1

2.80e-0427983GO:0035024
GeneOntologyBiologicalProcessmembrane depolarization

ANK2 ANK3 SCN2A SCN3A SCN8A

2.81e-04121985GO:0051899
GeneOntologyBiologicalProcesslymphocyte mediated immunity

PSG6 SVEP1 IGHA1 EXO1 DLG1 EBAG9 PSG8 CD96 NCKAP1L

2.88e-04449989GO:0002449
GeneOntologyBiologicalProcessregulation of vasculogenesis

PSG6 CD34 PSG8

3.47e-0429983GO:2001212
GeneOntologyBiologicalProcessstress fiber assembly

SORBS1 ITGB1 MET ALMS1 PHLDB2

3.51e-04127985GO:0043149
GeneOntologyBiologicalProcesscontractile actin filament bundle assembly

SORBS1 ITGB1 MET ALMS1 PHLDB2

3.51e-04127985GO:0030038
GeneOntologyBiologicalProcessactin-mediated cell contraction

ANK2 SCN2A SCN3A SCN8A DLG1

3.51e-04127985GO:0070252
GeneOntologyBiologicalProcessregulation of cell division

AHCTF1 E2F7 EVI2B BIRC6 KLHL13 ZFYVE26

3.98e-04201986GO:0051302
GeneOntologyBiologicalProcessaction potential

ANK2 ANK3 SCN2A SCN3A SCN8A DLG1

3.98e-04201986GO:0001508
GeneOntologyBiologicalProcesscytokinesis

ANK3 AHCTF1 E2F7 BIRC6 KLHL13 ZFYVE26

4.30e-04204986GO:0000910
GeneOntologyBiologicalProcessregulation of granulocyte differentiation

PSG6 EVI2B PSG8

5.12e-0433983GO:0030852
GeneOntologyBiologicalProcessendocytosis

ANK2 ANK3 PSG6 ITGB1 SH3BP4 MET VIPAS39 ALMS1 HGS LRP2 PSG8 NCKAP1L

5.47e-048279812GO:0006897
GeneOntologyBiologicalProcessregulation of response to wounding

PSG6 MUC16 ITGB1 OMG PSG8 PHLDB2

5.96e-04217986GO:1903034
GeneOntologyBiologicalProcessstriated muscle contraction

ANK2 MET SCN2A SCN3A SCN8A DLG1

5.96e-04217986GO:0006941
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization

ANK3 MAP1A MAP1B NCKAP5 EYA1 ITGB1 MET C2CD3 ALMS1 DLG1 PHLDB2

6.17e-047209811GO:0000226
GeneOntologyBiologicalProcesscirculatory system process

ANK2 PSG6 ITGB1 SVEP1 MET SCN2A SCN3A SCN8A LRP2 DLG1 PSG8

7.15e-047339811GO:0003013
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RANBP2 RGPD8 RGPD3

7.78e-0438983GO:0000413
GeneOntologyBiologicalProcessregulation of guanyl-nucleotide exchange factor activity

MET RIPOR1

7.87e-049982GO:1905097
GeneOntologyBiologicalProcessresponse to insecticide

MAP1B SCN3A

7.87e-049982GO:0017085
GeneOntologyBiologicalProcessactin filament-based movement

ANK2 SCN2A SCN3A SCN8A DLG1

8.21e-04153985GO:0030048
GeneOntologyCellularComponentnode of Ranvier

ANK3 SCN2A SCN8A DLG1

2.08e-0620984GO:0033268
GeneOntologyCellularComponentSUMO ligase complex

RANBP2 RGPD8 SLF2 RGPD3

2.56e-0621984GO:0106068
GeneOntologyCellularComponentmain axon

ANK3 MAP1A MAP1B SCN2A SCN8A DLG1

3.86e-0689986GO:0044304
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RANBP2 RGPD8 RGPD3

5.50e-068983GO:1990723
GeneOntologyCellularComponentaxon initial segment

ANK3 MAP1A SCN2A SCN8A

9.86e-0629984GO:0043194
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RANBP2 RGPD8 RGPD3

1.17e-0510983GO:0044614
GeneOntologyCellularComponentGolgi lumen

MUC3B MUC16 MUC12 VCAN MUC3A MUC6

1.25e-05109986GO:0005796
GeneOntologyCellularComponentintercalated disc

ANK2 ANK3 ITGB1 SCN2A DLG1

1.69e-0568985GO:0014704
GeneOntologyCellularComponentannulate lamellae

RANBP2 RGPD8 RGPD3

3.50e-0514983GO:0005642
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN2A SCN3A SCN8A

6.48e-0517983GO:0001518
GeneOntologyCellularComponentparanode region of axon

ANK3 SCN2A DLG1

6.48e-0517983GO:0033270
GeneOntologyCellularComponentnuclear pore nuclear basket

RANBP2 RGPD8 RGPD3

7.75e-0518983GO:0044615
GeneOntologyCellularComponentcell-cell contact zone

ANK2 ANK3 ITGB1 SCN2A DLG1

8.06e-0594985GO:0044291
GeneOntologyCellularComponentnuclear inclusion body

RANBP2 RGPD8 RGPD3

1.07e-0420983GO:0042405
GeneOntologyCellularComponentnuclear pore

RANBP2 RGPD8 AHCTF1 RGPD3 RGPD5

1.13e-04101985GO:0005643
GeneOntologyCellularComponentnascent polypeptide-associated complex

NACA NACAD

2.16e-045982GO:0005854
GeneOntologyCellularComponentsodium channel complex

SCN2A SCN3A SCN8A

3.34e-0429983GO:0034706
GeneOntologyCellularComponentbasal part of cell

ANK2 ANK3 PSG6 MET CD34 DLG1 PSG8 PHLDB2

4.05e-04378988GO:0045178
GeneOntologyCellularComponentadherens junction

PSG6 SORBS1 ITGB1 LMO7 DLG1 PSG8

4.91e-04212986GO:0005912
GeneOntologyCellularComponentT-tubule

ANK2 ANK3 SCN2A DLG1

5.21e-0479984GO:0030315
GeneOntologyCellularComponentmyelin sheath abaxonal region

ITGB1 DLG1

7.67e-049982GO:0035748
GeneOntologyCellularComponentlateral plasma membrane

ANK3 PSG6 DLG1 PSG8

8.52e-0490984GO:0016328
GeneOntologyCellularComponentbasal plasma membrane

ANK2 ANK3 PSG6 MET CD34 DLG1 PSG8

1.39e-03354987GO:0009925
GeneOntologyCellularComponentcell-cell junction

ANK2 ANK3 PSG6 SORBS1 ITGB1 LMO7 SCN2A DLG1 PSG8

1.83e-03591989GO:0005911
GeneOntologyCellularComponentsarcolemma

ANK2 ANK3 ITGB1 SCN2A DLG1

2.02e-03190985GO:0042383
GeneOntologyCellularComponentcell surface

RTP1 ANK3 PSG6 MUC16 ITGB1 MET LMO7 CD34 VCAN LPL CUZD1 LRP2 PSG8

2.03e-0311119813GO:0009986
GeneOntologyCellularComponenttransforming growth factor beta ligand-receptor complex

PSG6 PSG8

2.50e-0316982GO:0070021
GeneOntologyCellularComponentcilium

MAP1A MAP1B PSG6 SAXO1 DNAH14 MET C2CD3 ALMS1 VCAN PSG8 DNAI7

3.21e-038989811GO:0005929
GeneOntologyCellularComponentcentrosome

HIPK1 MAMLD1 SORBS1 SAXO1 BIRC6 C2CD3 ALMS1 CCNB3 CAPN7 ZFYVE26

3.28e-037709810GO:0005813
MousePhenoabnormal incidence of induced tumors

RANBP2 RGPD8 PSG6 HIPK1 ITGB1 CD34 RGPD3 PSG8 DNAI7 CD96

2.34e-062697810MP:0013151
MousePhenoabnormal tumor incidence

RANBP2 RGPD8 PSG6 HIPK1 ITGB1 MET LMO7 CD34 RGPD3 EXO1 PSG8 DNAI7 CD96

4.49e-056357813MP:0002019
MousePhenoabnormal tumor susceptibility

RANBP2 RGPD8 PSG6 HIPK1 ITGB1 MET LMO7 CD34 RGPD3 EXO1 PSG8 DNAI7 CD96

5.70e-056507813MP:0002166
MousePhenoincreased lung carcinoma incidence

RANBP2 RGPD8 LMO7 RGPD3 DNAI7

7.30e-0578785MP:0008714
MousePhenoPurkinje cell degeneration

ANK3 MAP1A HGS SCN8A ZFYVE26

8.74e-0581785MP:0000876
MousePhenoelevated level of mitotic sister chromatid exchange

RANBP2 RGPD8 RGPD3

8.88e-0516783MP:0003701
MousePhenoincreased incidence of tumors by chemical induction

RANBP2 RGPD8 PSG6 RGPD3 PSG8 DNAI7

1.34e-04141786MP:0004499
DomainRan_BP1

RANBP2 RGPD8 RGPD3 RGPD5

3.42e-0712984PF00638
DomainZU5

ANK2 ANK3 UNC5B SH3BP4

3.42e-0712984PF00791
DomainRANBD1

RANBP2 RGPD8 RGPD3 RGPD5

3.42e-0712984PS50196
DomainZU5_dom

ANK2 ANK3 UNC5B SH3BP4

3.42e-0712984IPR000906
DomainRanBD

RANBP2 RGPD8 RGPD3 RGPD5

4.91e-0713984SM00160
DomainRan_bind_dom

RANBP2 RGPD8 RGPD3 RGPD5

4.91e-0713984IPR000156
DomainNa_trans_cytopl

SCN2A SCN3A SCN8A

2.77e-066983PF11933
DomainNa_trans_cytopl

SCN2A SCN3A SCN8A

2.77e-066983IPR024583
DomainSEA

MUC3B MUC16 MUC12 MUC3A

5.85e-0623984PS50024
DomainSEA_dom

MUC3B MUC16 MUC12 MUC3A

5.85e-0623984IPR000082
DomainZU5

ANK2 ANK3 UNC5B

1.15e-059983SM00218
DomainNa_channel_asu

SCN2A SCN3A SCN8A

1.64e-0510983IPR001696
DomainNa_trans_assoc

SCN2A SCN3A SCN8A

1.64e-0510983IPR010526
DomainZU5

ANK2 ANK3 UNC5B

1.64e-0510983PS51145
DomainNa_trans_assoc

SCN2A SCN3A SCN8A

1.64e-0510983PF06512
DomainGrip

RGPD8 RGPD3 RGPD5

2.24e-0511983SM00755
DomainGRIP

RGPD8 RGPD3 RGPD5

2.24e-0511983PF01465
DomainGRIP_dom

RGPD8 RGPD3 RGPD5

2.98e-0512983IPR000237
DomainGRIP

RGPD8 RGPD3 RGPD5

2.98e-0512983PS50913
DomainSEA

MUC3B MUC16 MUC3A

4.89e-0514983SM00200
DomainMAP1

MAP1A MAP1B

8.15e-053982IPR026074
DomainEGD2/NACA

NACA NACAD

8.15e-053982IPR016641
DomainSEA

MUC3B MUC16 MUC12

2.01e-0422983PF01390
DomainNAC

NACA NACAD

2.70e-045982SM01407
DomainDEATH

ANK2 ANK3 UNC5B

3.74e-0427983SM00005
DomainEGF_1

MUC3B MUC12 ITGB1 SVEP1 VCAN LRP2 MUC3A

3.92e-04255987PS00022
DomainNAC

NACA NACAD

4.03e-046982PF01849
DomainNas_poly-pep-assoc_cplx_dom

NACA NACAD

4.03e-046982IPR002715
DomainNAC_AB

NACA NACAD

4.03e-046982PS51151
DomainEGF-like_CS

MUC3B MUC12 ITGB1 SVEP1 VCAN LRP2 MUC3A

4.50e-04261987IPR013032
DomainGCC2_Rab_bind

RGPD8 RGPD3

5.63e-047982IPR032023
DomainRab_bind

RGPD8 RGPD3

5.63e-047982PF16704
Domain-

COL6A5 ITGB1 SVEP1 ITIH6

6.19e-04749843.40.50.410
DomainDeath

ANK2 ANK3 UNC5B

6.82e-0433983PF00531
DomainIQ

UBE3B SCN2A SCN3A SCN8A

8.70e-0481984SM00015
DomainVWFA

COL6A5 ITGB1 SVEP1 ITIH6

9.11e-0482984PS50234
DomainVWA

COL6A5 ITGB1 SVEP1 ITIH6

9.97e-0484984SM00327
DomainDeath_domain

ANK2 ANK3 UNC5B

1.03e-0338983IPR000488
DomainDEATH_DOMAIN

ANK2 ANK3 UNC5B

1.03e-0338983PS50017
DomainSH3_2

SRMS SORBS1 SH3BP4 DLG1

1.09e-0386984IPR011511
DomainSH3_2

SRMS SORBS1 SH3BP4 DLG1

1.09e-0386984PF07653
DomainTPR-contain_dom

RANBP2 RGPD8 RGPD3 TTC13 RGPD5

1.17e-03150985IPR013026
Domain-

RGPD8 RGPD3

1.19e-03109821.10.220.60
DomainTPR_1

RANBP2 RGPD8 TTC13 RGPD5

1.29e-0390984PF00515
DomainTPR_1

RANBP2 RGPD8 TTC13 RGPD5

1.29e-0390984IPR001440
DomainIQ_motif_EF-hand-BS

UBE3B SCN2A SCN3A SCN8A

1.29e-0390984IPR000048
DomainTPR-like_helical_dom

RANBP2 RGPD8 CAPN7 RGPD3 TTC13 RGPD5

1.43e-03233986IPR011990
DomainIQ

UBE3B SCN2A SCN3A SCN8A

1.46e-0393984PS50096
DomainTPR_REGION

RANBP2 RGPD8 RGPD3 TTC13 RGPD5

1.78e-03165985PS50293
DomainTPR

RANBP2 RGPD8 RGPD3 TTC13 RGPD5

1.78e-03165985PS50005
DomainVWF_A

COL6A5 ITGB1 SVEP1 ITIH6

1.83e-0399984IPR002035
DomainTIL_dom

LRP2 MUC6

2.38e-0314982IPR002919
DomainAnkyrin_rpt

RTP1 ANK2 ANK3 PPP1R12B IBTK EXO1

2.58e-03262986IPR002110
DomainEGF_2

MUC3B MUC12 SVEP1 VCAN LRP2 MUC3A

2.73e-03265986PS01186
DomainVWA

COL6A5 SVEP1 ITIH6

3.17e-0356983PF00092
DomainChannel_four-helix_dom

SCN2A SCN3A SCN8A

3.34e-0357983IPR027359
Domain-

SCN2A SCN3A SCN8A

3.34e-03579831.20.120.350
DomainEGF_extracell

ITGB1 SVEP1 LRP2

3.86e-0360983IPR013111
DomainEGF_2

ITGB1 SVEP1 LRP2

3.86e-0360983PF07974
DomainIg-like_fold

FNDC3B PSG6 UNC5B SPEG MET PTPRB IGHA1 VCAN PSG8 CD96

3.92e-037069810IPR013783
DomainTPR

RANBP2 RGPD8 RGPD3 TTC13

4.76e-03129984SM00028
Domain-

MAP1A MAP1B

4.87e-03209823.60.15.10
DomainMetallo-B-lactamas

MAP1A MAP1B

4.87e-0320982IPR001279
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

ANK2 ANK3 SCN2A SCN3A SCN8A

6.07e-0731765M877
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC16 MUC12 MUC3A MUC6

1.35e-0616764M27410
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC16 MUC12 MUC3A MUC6

1.76e-0617764M27412
PathwayREACTOME_L1CAM_INTERACTIONS

ANK2 ANK3 ITGB1 SCN2A SCN3A SCN8A DLG1

3.86e-06121767M872
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC16 MUC12 MUC3A MUC6

6.39e-0623764M556
PathwayREACTOME_DECTIN_2_FAMILY

MUC16 MUC12 MUC3A MUC6

1.07e-0526764M27483
PathwayWP_DRAVET_SYNDROME

PCDH19 SCN2A SCN3A SCN8A

1.45e-0528764M45519
PathwayKEGG_ADHERENS_JUNCTION

SORBS1 FARP2 MET PTPRB LMO7

4.50e-0573765M638
PathwayBIOCARTA_RANBP2_PATHWAY

RANBP2 RGPD8 RGPD3

1.16e-0418763MM1549
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

ANK2 ANK3 UNC5B COL6A5 ITGB1 FARP2 MET SCN2A SCN3A SCN8A DLG1

2.43e-045757611M29853
PathwayREACTOME_MET_INTERACTS_WITH_TNS_PROTEINS

ITGB1 MET

2.84e-045762M27775
PathwayREACTOME_MET_INTERACTS_WITH_TNS_PROTEINS

ITGB1 MET

2.84e-045762MM15514
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

MUC16 MUC12 MUC3A MUC6

3.43e-0462764M546
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

PSG6 IBSP COL6A5 ITGB1 CAPN7 VCAN PSG8

4.73e-04258767MM14572
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

MUC16 MUC12 MUC3A MUC6

4.89e-0468764M27303
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN2A SCN3A SCN8A

6.67e-0432763M27455
PathwayREACTOME_ECM_PROTEOGLYCANS

IBSP COL6A5 ITGB1 VCAN

7.46e-0476764M27219
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

RGPD8 RADX NACA ITGB1 BIRC6 FARP2 IBTK VIPAS39 ALMS1 MACO1 HGS DLG1 TTC13 R3HDM1 MGA

2.61e-09733991534672954
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

ANK3 SCN2A SCN3A SCN8A

3.00e-081299430175250
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RANBP2 RGPD8 ANK3 RGPD3

4.33e-081399431427429
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN2A SCN3A SCN8A

8.93e-08499317537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN2A SCN3A SCN8A

8.93e-08499335031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN2A SCN3A SCN8A

8.93e-08499329578003
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RANBP2 RGPD8 RGPD5

8.93e-0849939480752
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC16 MUC12 MUC3A MUC6

1.83e-071899418834073
Pubmed

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.

ANK2 ANK3 SCN2A SCN8A

1.83e-071899437321992
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A SCN8A

2.23e-07599317724025
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ANK3 UNC5B ITGB1 FARP2 MET PCDH19 HGS DLG1 EBAG9 PHLDB2

3.63e-07421991036976175
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN2A SCN3A SCN8A

4.45e-07699323652591
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RANBP2 RGPD8 RGPD3

7.77e-0779939037092
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD8 RGPD3 RGPD5

7.77e-07799315710750
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

PCDH19 SCN2A SCN8A

7.77e-07799325818041
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RANBP2 RGPD8 RGPD3

7.77e-07799311353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RANBP2 RGPD8 RGPD3

7.77e-07799330944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RANBP2 RGPD8 RGPD3

7.77e-07799338838144
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RANBP2 RGPD8 RGPD3

7.77e-0779937559465
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RANBP2 RGPD8 RGPD3

7.77e-07799317372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RANBP2 RGPD8 RGPD3

7.77e-07799338657106
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RANBP2 RGPD8 RGPD3

7.77e-07799321205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RANBP2 RGPD8 RGPD3

7.77e-07799318949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RANBP2 RGPD8 RGPD3

7.77e-07799325187515
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RANBP2 RGPD8 RGPD3

7.77e-0779938603673
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RANBP2 RGPD8 RGPD3

7.77e-07799326632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RANBP2 RGPD8 RGPD3

7.77e-07799324403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RANBP2 RGPD8 RGPD3

7.77e-07799323818861
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RANBP2 RGPD8 RGPD3

7.77e-07799323536549
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RANBP2 RGPD8 RGPD3

7.77e-07799312191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RANBP2 RGPD8 RGPD3

7.77e-07799322821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RANBP2 RGPD8 RGPD3

7.77e-07799320682751
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

RANBP2 ANK2 RGPD8 ANK3 MAP1A MAP1B NACA SORBS1 BIRC6 NACAD MET VIPAS39 UBAP2L RGPD3 DLG1

8.03e-071139991536417873
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

RANBP2 ANK3 RADX AHCTF1 ALMS1 MACO1 HGS R3HDM1

9.09e-0726399834702444
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RANBP2 RGPD8 RGPD3

1.24e-06899321670213
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RANBP2 RGPD8 RGPD3

1.24e-06899327412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RANBP2 RGPD8 RGPD3

1.24e-06899321310149
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RANBP2 RGPD8 RGPD3

1.24e-06899322262462
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RANBP2 RGPD8 RGPD3

1.24e-06899328745977
Pubmed

A human MAP kinase interactome.

RANBP2 ANK3 MAP1A HIPK1 NCKAP5 SORBS1 MUC12 SH3BP4 HGS MGA

1.33e-06486991020936779
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RANBP2 RGPD8 RGPD3

1.86e-06999318394993
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN2A SCN3A SCN8A

1.86e-06999316382098
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RANBP2 RGPD8 RGPD3

1.86e-06999328100513
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RANBP2 RGPD8 RGPD3

1.86e-06999317887960
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RANBP2 RGPD8 RGPD3

1.86e-06999311553612
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RANBP2 RGPD8 RGPD3

1.86e-06999310601307
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RANBP2 RGPD8 RGPD3

1.86e-0699939733766
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN2A SCN3A SCN8A

1.86e-06999315746173
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RANBP2 RGPD8 RGPD3

1.86e-06999328877029
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

FNDC3B MAP1B UBE3B NACA NPLOC4 SH3BP4 FARP2 IBTK LPL DLG1 PARP12

2.54e-06650991138777146
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RANBP2 RGPD8 RGPD3

2.65e-061099327160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RANBP2 RGPD8 RGPD3

2.65e-061099316332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RANBP2 RGPD8 RGPD3

2.65e-06109938857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RANBP2 RGPD8 RGPD3

2.65e-061099321859863
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RANBP2 RGPD8 RGPD3

3.63e-061199317069463
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RANBP2 RGPD8 RGPD3

3.63e-061199335771867
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RANBP2 RGPD8 RGPD3

3.63e-061199334110283
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RANBP2 RGPD8 AHCTF1 RGPD3

4.23e-063899412791264
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

RANBP2 RGPD8 MAP1A MAP1B SPEG SORBS1 RGPD3

4.61e-0623199716452087
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

RANBP2 MAP1A MAP1B MAMLD1 ITGB1 SLF2 UBAP2L RGPD3 MGA

5.21e-0644499934795231
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

SPEG SORBS1 IBTK KLHL13 PCDH19 SCN3A

5.25e-0615399610718198
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

SORBS1 BIRC6 VIPAS39 ALMS1 LMO7 HGS EXO1 R3HDM1 PHLDB2

5.41e-0644699924255178
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

RANBP2 ANK2 ANK3 MAP1B UNC5B AHCTF1 ITGB1 NPLOC4 UBAP2L HGS DLG1

5.73e-06708991139231216
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN2A SCN3A SCN8A

6.27e-061399315123669
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

RGPD8 MAP1A RADX HIPK1 E2F7 SORBS1 ALMS1 SLF2 LMO7 MACO1

7.15e-06588991038580884
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

8.02e-06299220346423
Pubmed

Regulation of microtubule-associated protein 1B (MAP1B) subunit composition.

MAP1A MAP1B

8.02e-06299211002287
Pubmed

Commonalities and distinctions between two neurodevelopmental disorder subtypes associated with SCN2A and SCN8A variants and literature review.

SCN2A SCN8A

8.02e-06299235348308
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

8.02e-06299211245985
Pubmed

Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.

SCN2A SCN8A

8.02e-06299215760941
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

8.02e-06299223016767
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

8.02e-06299227153334
Pubmed

Interaction of voltage-gated sodium channel Nav1.6 (SCN8A) with microtubule-associated protein Map1b.

MAP1B SCN8A

8.02e-06299222474336
Pubmed

Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B.

MUC3B MUC3A

8.02e-06299210973822
Pubmed

Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling.

MUC16 ITGB1

8.02e-06299235628269
Pubmed

Heterotypic complex formation between subunits of microtubule-associated proteins 1A and 1B is due to interaction of conserved domains.

MAP1A MAP1B

8.02e-06299216996626
Pubmed

Targeting the hepatocyte growth factor/c-Met signaling pathway in renal cell carcinoma.

MET HGS

8.02e-06299223867513
Pubmed

Oligomerization-induced differential dephosphorylation of c-Met receptor tyrosine kinase.

MET PTPRB

8.02e-06299216101282
Pubmed

Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a.

SCN2A SCN8A

8.02e-06299218601978
Pubmed

The mouse and rat MAP1B genes: genomic organization and alternative transcription.

MAP1A MAP1B

8.02e-0629929615228
Pubmed

FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels.

SCN2A SCN8A

8.02e-06299219465131
Pubmed

Delayed development of nervous system in mice homozygous for disrupted microtubule-associated protein 1B (MAP1B) gene.

MAP1A MAP1B

8.02e-0629929199175
Pubmed

Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis.

SCN2A SCN8A

8.02e-06299223735284
Pubmed

Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15.

MAP1A MAP1B

8.02e-0629927806212
Pubmed

Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6.

ANK3 SCN8A

8.02e-06299216775201
Pubmed

beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/versican.

ITGB1 VCAN

8.02e-06299211805102
Pubmed

Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus.

MUC3B MUC3A

8.02e-06299212958310
Pubmed

Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro.

LPL LRP2

8.02e-0629927686151
Pubmed

Oligodendrocyte myelin glycoprotein does not influence node of ranvier structure or assembly.

OMG VCAN

8.02e-06299220980605
Pubmed

Sodium channel expression within chronic multiple sclerosis plaques.

SCN2A SCN8A

8.02e-06299217805013
Pubmed

MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region.

MUC3B MUC3A

8.02e-0629929334251
Pubmed

The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes.

ANK2 ANK3

8.02e-06299211781319
Pubmed

Structural basis of diverse membrane target recognitions by ankyrins.

ANK2 ANK3

8.02e-06299225383926
Pubmed

Molecular cloning of cDNAs derived from a novel human intestinal mucin gene.

MUC3B MUC3A

8.02e-0629922393399
Pubmed

Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease.

MUC3B MUC3A

8.02e-06299211289722
Pubmed

Role of c-Met/β1 integrin complex in the metastatic cascade in breast cancer.

ITGB1 MET

8.02e-06299234003803
Pubmed

Neuronal abnormalities in microtubule-associated protein 1B mutant mice.

MAP1A MAP1B

8.02e-0629928577753
Pubmed

Molecular cloning of microtubule-associated protein 1 (MAP1A) and microtubule-associated protein 5 (MAP1B): identification of distinct genes and their differential expression in developing brain.

MAP1A MAP1B

8.02e-0629922355215
Pubmed

Interaction of the Nav1.2a subunit of the voltage-dependent sodium channel with nodal ankyrinG. In vitro mapping of the interacting domains and association in synaptosomes.

ANK3 SCN2A

8.02e-06299212036953
Pubmed

Preferential targeting of Nav1.6 voltage-gated Na+ Channels to the axon initial segment during development.

ANK3 SCN8A

8.02e-06299225874799
InteractionRGPD4 interactions

RANBP2 RGPD8 RGPD3 RGPD5

3.45e-0622974int:RGPD4
InteractionGJA1 interactions

ANK3 MAP1B UNC5B ITGB1 SH3BP4 MET MACO1 PCDH19 HGS LRP2 DLG1 EBAG9 PHLDB2

4.38e-065839713int:GJA1
InteractionRGPD2 interactions

RANBP2 RGPD8 RGPD3 RGPD5

8.13e-0627974int:RGPD2
InteractionC11orf52 interactions

ANK3 UNC5B ITGB1 SH3BP4 FARP2 MET HGS DLG1 PHLDB2

1.92e-05311979int:C11orf52
InteractionESRP1 interactions

RANBP2 RGPD8 BIRC6 RGPD3 RGPD5

3.50e-0577975int:ESRP1
InteractionTRAF3IP3 interactions

RANBP2 RGPD8 EVI2B EBAG9 RGPD5

5.32e-0584975int:TRAF3IP3
InteractionNEDD4 interactions

ANK3 NACA SRMS RB1CC1 BIRC6 UBAP2L SCN2A SCN3A HGS SCN8A EBAG9

6.13e-055449711int:NEDD4
InteractionKCNA3 interactions

RANBP2 ANK2 ANK3 MAP1B UNC5B AHCTF1 NACA AKNAD1 ITGB1 NPLOC4 UBAP2L HGS LRP2 DLG1

7.11e-058719714int:KCNA3
InteractionRGPD3 interactions

RANBP2 RGPD8 RGPD3 RGPD5

7.67e-0547974int:RGPD3
InteractionNPIPB6 interactions

RANBP2 RGPD8 RGPD5

8.37e-0518973int:NPIPB6
InteractionRGPD1 interactions

RANBP2 RGPD8 RGPD3 RGPD5

9.05e-0549974int:RGPD1
Cytoband7q22

MUC3B MUC12 MUC3A

7.77e-05389937q22
Cytoband2q13

RGPD8 RGPD3 RGPD5

4.40e-04689932q13
GeneFamilyCD molecules|Mucins

MUC3B MUC16 MUC12 MUC3A MUC6

1.36e-0821695648
GeneFamilySodium voltage-gated channel alpha subunits

SCN2A SCN3A SCN8A

4.40e-0696931203
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RANBP2 RGPD8 RGPD3 TTC13 RGPD5

7.75e-05115695769
GeneFamilyCD molecules|V-set domain containing|Pregnancy specific glycoproteins

PSG6 PSG8

7.72e-04116921315
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP

RANBP2 RGPD8 RGPD3 PARP12

6.92e-0633984MM477
CoexpressionSMID_BREAST_CANCER_LUMINAL_B_DN

FNDC3B ANK2 MAP1B MUC16 SVEP1 MET IGHA1 VCAN LPL PLAGL1 CD96

1.25e-055879811M17572
CoexpressionAtlasDevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_k-means-cluster#3_top-relative-expression-ranked_500

TMEM69 IBTK C2CD3 SCN8A LRP2 PARPBP

1.71e-05122946gudmap_developingLowerUrinaryTract_e15.5_Urothelium_500_k3
ToppCellNeuron-Postmitotic-Excitatory_Neuron_|World / Primary Cells by Cluster

ANK2 ANK3 MAP1B LMO7 SCN2A LPL SCN3A R3HDM1

1.42e-08199988058373b4ac3cec2108cb24265628ff0a50646e33
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

ANK2 ANK3 MAP1B LMO7 SCN2A LPL SCN3A R3HDM1

1.48e-08200988db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

ANK2 ANK3 MAP1B LMO7 SCN2A LPL SCN3A R3HDM1

1.48e-0820098830a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-Cycling_Dendritic|bone_marrow / Manually curated celltypes from each tissue

MAP1A E2F7 SH3BP4 ESCO2 KLHL13 EXO1 LRP2

1.79e-071859879d3168c7f0b1d739f78b368969cf5c77ce202b97
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

ANK2 ANK3 NCKAP5 SORBS1 EYA1 LPL PHLDB2

2.07e-071899870a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

ANK2 ANK3 NCKAP5 SORBS1 EYA1 LPL PHLDB2

2.14e-0719098793c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ANK2 ANK3 PPP1R12B NCKAP5 SORBS1 LMO7 LPL

2.38e-07193987dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RANBP2 SORBS1 RB1CC1 ITGB1 PTPRB LMO7 PLAGL1

2.47e-07194987e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellCOVID-19-Heart-CM_1|Heart / Disease (COVID-19 only), tissue and cell type

ANK2 ANK3 PPP1R12B NCKAP5 SORBS1 LMO7 LPL

2.56e-07195987f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

ANK2 ANK3 PPP1R12B NCKAP5 SORBS1 LMO7 LPL

2.56e-0719598775fc81bddb246dca3b437fb60827b1d4fe416405
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

ANK2 ANK3 NACA LMO7 SCN2A LPL R3HDM1

2.93e-071999871b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

ANK2 ANK3 NACA LMO7 SCN2A LPL R3HDM1

2.93e-071999874bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

E2F7 ESCO2 SCN2A SCN3A EXO1 PARPBP

2.93e-06180986401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCellCOVID-19-Heart-CM_3|Heart / Disease (COVID-19 only), tissue and cell type

ANK3 NCKAP5 SORBS1 LMO7 LPL DLG1

3.12e-06182986287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAP1B SORBS1 ITGB1 VCAN PCDH19 PHLDB2

3.22e-06183986af8d86f15a549064530d94bd47081daf59d58ecd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

FNDC3B SORBS1 SVEP1 KLHL13 VCAN CD96

3.32e-06184986d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

ANK2 ANK3 PPP1R12B SORBS1 LMO7 LPL

3.32e-06184986ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

ANK2 ANK3 PPP1R12B SORBS1 LMO7 LPL

3.43e-061859866baccb26f999145e51b91d94315bf8d4655bef31
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EYA1 ITGB1 PTPRB LMO7 PLAGL1 PHLDB2

3.54e-061869860ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

MAP1B SPEG PPP1R12B SORBS1 VCAN PHLDB2

3.65e-06187986464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FNDC3B EYA1 SH3BP4 KLHL13 SCN2A SCN3A

3.88e-06189986975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FNDC3B EYA1 SH3BP4 KLHL13 SCN2A SCN3A

3.88e-061899867eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP1B UNC5B SH3BP4 PTPRB CD34 LPL

3.88e-06189986b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellP07|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ANK2 MAP1B UNC5B ITGB1 CD34 PHLDB2

4.00e-0619098638a613a9bca0ba040c3ada00286d1ce6f83ab23a
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

UNC5B NCKAP5 SORBS1 PTPRB CD34 RIPOR1

4.00e-06190986106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

ANK2 ANK3 PPP1R12B NCKAP5 SORBS1 LMO7

4.00e-06190986fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

ANK2 ANK3 PPP1R12B NCKAP5 SORBS1 LMO7

4.12e-061919865d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

RANBP2 HIPK1 RB1CC1 JUND MACO1 RGPD5

4.12e-061919861ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCellfacs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCKAP5 SORBS1 PTPRB LPL RIPOR1 PHLDB2

4.24e-061929864bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

ANK2 ANK3 PPP1R12B NCKAP5 SORBS1 LMO7

4.50e-0619498689812fb164065041357bb37a3c2d87028ec3de4e
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

ANK2 ANK3 PPP1R12B NCKAP5 SORBS1 LMO7

4.50e-06194986c3535f7cc0076653c72db582047cff053c322397
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ANK3 NCKAP5 EYA1 SH3BP4 MET LMO7

5.06e-06198986af399569c718f5fd971d73a7926768c9311002a3
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ANK3 NCKAP5 EYA1 SH3BP4 MET LMO7

5.06e-061989861408e02e053ad3406229bfe8189da03be6366e81
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANK3 MAP1B SCN2A SCN3A SCN8A R3HDM1

5.06e-061989860ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_IV-2|World / Primary Cells by Cluster

ANK2 ANK3 MAP1B SCN2A LPL R3HDM1

5.21e-06199986f09b40245d3d826275bbe5f508dedccc75a911bd
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_IV|World / Primary Cells by Cluster

ANK2 ANK3 MAP1B SCN2A LPL R3HDM1

5.21e-06199986e45448ec4db8875c8aaa9aad109a10e2905a4226
ToppCellNeuron|World / Primary Cells by Cluster

ANK2 ANK3 MAP1B SCN2A SCN3A R3HDM1

5.21e-061999861f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCellNeuron-Postmitotic|World / Primary Cells by Cluster

ANK2 ANK3 MAP1B SCN2A SCN3A R3HDM1

5.21e-061999861973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

ANK3 MAP1B SCN2A SCN3A SCN8A R3HDM1

5.36e-0620098648d801219bc771d6c7e151dc88ca4c179988de85
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital|World / Primary Cells by Cluster

ANK2 ANK3 MAP1B NACA LPL R3HDM1

5.36e-062009866bbe8e1f3e91678f1bfb14945365c1578a59a604
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital-19|World / Primary Cells by Cluster

ANK2 ANK3 MAP1B NACA LPL R3HDM1

5.36e-06200986c831d9e0a7178e3634da45548f91fa9e8dc6557c
ToppCellCOVID-19_Severe-dn_T|COVID-19_Severe / Disease condition and Cell class

PPP1R12B EVI2B MET IBTK LPL

1.57e-051429852008033881b9e1b20926c3508d6ebdb6f1a1528f
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

MUC16 EYA1 MET LMO7 DNAI7

2.10e-051519858216462e723fec2797387929dde095370947e10a
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 SAXO1 SVEP1 LRP2 SPESP1

2.78e-05160985c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A5 SAXO1 SVEP1 LRP2 SPESP1

2.78e-0516098525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellLPS-antiTNF-Endothelial-Endothelial-FOXM1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

E2F7 ESCO2 PTPRB EXO1 PARPBP

3.04e-051639855285318c52aa31c9b22dc2ffff078e32e408604d
ToppCell10x5'-Liver-Lymphocytic_Invariant-Inducer-like-ILC3|Liver / Manually curated celltypes from each tissue

NCKAP5 NACAD DNAH14 SH3BP4 KLHL13

3.04e-051639857f61483eeb1fde21843c6391468e13cb0cc2a89f
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

RGPD8 UNC5B VCAN LPL LRP2

3.31e-05166985f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

HIPK1 UBE3B FAM186B UBAP2L MGA

3.31e-0516698532d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCellEndothelial-B-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

ANK2 MAP1B PTPRB CD34 SCN3A

3.31e-05166985c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

HIPK1 NCKAP5 IGHA1 UBAP2L ZFYVE26

3.51e-051689858459d0a1bf6d4b5c83001097331f8b78fceb9305
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TMEM69 MAMLD1 CD34 DNAI7 PARP12

3.51e-0516898555c9de7b3a1d6cf7b02b020ff92ab4ede8d195cc
ToppCellsevere-HSPC|World / disease stage, cell group and cell class

DNAH14 CD34 KLHL13 SCN2A SPESP1

3.61e-05169985b0421b73bfdc92f7a2762b4b670b9eae124aa702
ToppCelldroplet-Skin-nan-18m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK2 EYA1 SVEP1 VCAN DNAI7

3.71e-0517098510e0912dd0beab5d0bbe2bd49e477b5962687925
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

E2F7 ESCO2 MET IGHA1 EXO1

3.82e-0517198513126a3fbee181412c13ffb0c347277b9d8f16f7
ToppCellEndothelial-B-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

MAP1B AKNAD1 PTPRB CD34 SCN3A

3.93e-051729858a527dff06d841a86c7eb04a1dd9630787294da4
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAP1B UNC5B EYA1 SCN3A EXO1

3.93e-051729851bad7b19724e1b53ace7e05644215334c9f43910
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PSG6 E2F7 ESCO2 EXO1 PARPBP

4.15e-0517498584da9faff088d05233183b425385beb054c92d1b
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

MUC16 EYA1 MET SYCP2 UGT2A1

4.15e-051749857d2f802f493f19a068e097b2909a9000e2160266
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage|343B / Donor, Lineage, Cell class and subclass (all cells)

RGPD8 UNC5B EVI2B VCAN LPL

4.26e-05175985d3890bd0c570bb81434fdd1c5229891cefe2e462
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP1B MAMLD1 JUND KLHL13 LPL

4.38e-051769853027d34fd663c8a08544d469183dc45138916749
ToppCellfacs-Heart-LA-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPEG PPP1R12B SYCP2 SCN3A SPESP1

4.50e-0517798532fecefba1a55e1f418c9a055236fa11175c692d
ToppCellfacs-Heart-LA-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPEG PPP1R12B SYCP2 SCN3A SPESP1

4.50e-051779851b153fbfe1323dc589de4af73a52149ea5ce6763
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A E2F7 MUC12 ALMS1 DNAI7

4.75e-05179985d15182c668d7c37be8214cad9f1fe35d1409c9a1
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A E2F7 MUC12 ALMS1 DNAI7

4.75e-05179985e22a275a7c0ed19113c833a75d6c49fcc19aa13a
ToppCellAdult-Epithelial-lung_goblet_cell|Adult / Lineage, Cell type, age group and donor

MUC16 EYA1 MET SYCP2 UGT2A1

4.75e-051799851fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1A MAP1B COL6A5 SVEP1 VCAN

5.00e-05181985c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1A MAP1B COL6A5 SVEP1 VCAN

5.00e-05181985c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

ANK2 RFX6 SCN2A SCN3A SCN8A

5.13e-0518298557bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NCKAP5 EYA1 SH3BP4 MET LMO7

5.13e-05182985215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellEpithelial-lung_goblet_cell|World / Lineage, Cell type, age group and donor

MUC16 EYA1 MET SYCP2 UGT2A1

5.27e-05183985940cbe298e9c53b5622af09264586ed823d3141f
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_int|lung / Disease (COVID-19 only), tissue and cell type

EVI2B IGHA1 SCN3A EXO1 PARPBP

5.41e-05184985480595a0e2e6aa2a77b7daa36490ae3af3d8dfee
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK3 MAP1B SPEG PPP1R12B KLHL13

5.69e-051869856add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MUC16 RFX6 JUND VCAN SCN2A

5.69e-0518698523b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANK2 RFX6 SCN2A SCN3A SCN8A

5.69e-05186985b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellAT1_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ANK2 NCKAP5 LMO7 MUC3A PHLDB2

5.84e-05187985f1dda349335e08dbfc8395d373924037f5ad2fd6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EYA1 MET KLHL13 SCN2A SCN3A

5.84e-05187985f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

ANK2 ANK3 PPP1R12B NCKAP5 SORBS1

5.99e-051889856d249fe92d51a19da19ec14bb2262d394255d577
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP1B MAMLD1 KLHL13 LPL SCN3A

5.99e-05188985e99e3765b48392c987cf0c5ccbded0655637d7b7
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RANBP2 HIPK1 AHCTF1 RB1CC1 BIRC6

5.99e-05188985ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ANK2 RFX6 SCN2A SCN3A SCN8A

5.99e-05188985c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellPericytes-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

MAP1B SPEG PPP1R12B CD96 PHLDB2

5.99e-0518898514c1c88a944c66f2eaac1ce7526815dcce1f5147
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP1B MAMLD1 JUND KLHL13 LPL

6.14e-05189985ce3fbaf9642785c8adf6edaeae20998bca558928
ToppCellRV-04._Ventricular_Cardiomyocyte_I|RV / Chamber and Cluster_Paper

ANK2 ANK3 PPP1R12B NCKAP5 LMO7

6.14e-051899859c1debd65c13d63fd4f3158917d621b44b714c26
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

ANK2 PPP1R12B SORBS1 LMO7 LPL

6.14e-051899855e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ANK3 EYA1 MET LMO7 LRP2

6.14e-051899857659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EYA1 MET KLHL13 SCN2A SCN3A

6.14e-05189985e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCellInt-URO-Lymphocyte-T_NK-T_NK_proliferative|Int-URO / Disease, Lineage and Cell Type

E2F7 ESCO2 SCN8A EXO1 PARPBP

6.30e-05190985005967c540418b85311308072a07c684f4296aef
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B MAMLD1 SORBS1 FAM186B SVEP1

6.30e-051909851121eb607a984c59fbffe7220837fc178745aa55
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC3B SVEP1 CD34 VCAN LPL

6.30e-05190985bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC3B SVEP1 CD34 VCAN LPL

6.30e-05190985e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B MAMLD1 SORBS1 FAM186B SVEP1

6.30e-05190985048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A E2F7 MUC16 MUC12 DNAI7

6.30e-051909850adb24dafa077156bbc73a8d8cbf3d9eeb6e08df
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC3B SVEP1 CD34 VCAN LPL

6.30e-05190985ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B SPEG PPP1R12B SORBS1 PLAGL1

6.30e-05190985562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B SPEG SORBS1 SVEP1 VCAN

6.30e-0519098570c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B SPEG PPP1R12B SORBS1 PLAGL1

6.30e-05190985f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1A E2F7 MUC16 MUC12 DNAI7

6.30e-0519098505455775845f4ded5c27e7b83242078d23162aaf
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

E2F7 ESCO2 PTPRB EXO1 PARPBP

6.30e-05190985e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

ANK3 MUC16 EYA1 MET LMO7

6.30e-0519098551ca9ef4df3220487152fcf684147730637c7cc1
ComputationalGenes in the cancer module 240.

EVI2B PLAGL1 MGA

1.68e-0420593MODULE_240
ComputationalGenes in the cancer module 156.

EVI2B PLAGL1 MGA

2.25e-0422593MODULE_156
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN3A SCN8A

1.58e-066993ctd:C475726
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN2A SCN3A SCN8A

4.40e-068993ctd:C489827
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN2A SCN3A SCN8A

3.94e-0610963DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN2A SCN3A SCN8A

3.94e-0610963DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN2A SCN3A SCN8A

7.19e-0612963DOID:0060170 (implicated_via_orthology)
DiseaseBenign familial infantile epilepsy

SCN2A SCN8A

3.14e-053962cv:C5575231
Diseasecholangiocarcinoma (is_marker_for)

MUC16 MET MUC3A MUC6

5.76e-0564964DOID:4947 (is_marker_for)
DiseaseFamilial benign neonatal epilepsy

SCN2A SCN8A

1.56e-046962C0220669
Diseasehepatocyte growth factor receptor measurement

PSG6 MET

2.18e-047962EFO_0008153
Diseaseheel bone mineral density, urate measurement

EYA1 DNAH14 MET PLAGL1 PHLDB2

3.28e-04182965EFO_0004531, EFO_0009270
Diseasefish oil supplement exposure measurement, triglyceride measurement

MAP1A LPL

4.63e-0410962EFO_0004530, EFO_0600007
DiseasePolydactyly

UBE3B C2CD3 ALMS1 CD96

5.89e-04117964C0152427
Diseasethyroid gland carcinoma (is_marker_for)

PTPRB CD34

6.77e-0412962DOID:3963 (is_marker_for)
DiseaseInfantile Severe Myoclonic Epilepsy

PCDH19 SCN2A

7.98e-0413962C0751122
DiseaseGrand Mal Status Epilepticus

ANK3 JUND SCN8A

1.37e-0367963C0311335
DiseaseStatus Epilepticus, Subclinical

ANK3 JUND SCN8A

1.37e-0367963C0751522
DiseaseSimple Partial Status Epilepticus

ANK3 JUND SCN8A

1.37e-0367963C0751524
DiseaseNon-Convulsive Status Epilepticus

ANK3 JUND SCN8A

1.37e-0367963C0751523
DiseasePetit mal status

ANK3 JUND SCN8A

1.37e-0367963C0270823
DiseaseComplex Partial Status Epilepticus

ANK3 JUND SCN8A

1.37e-0367963C0393734
Diseasehemorrhoid

MUC12 BIRC6 LMO7 PHLDB2

1.38e-03147964EFO_0009552
DiseaseStatus Epilepticus

ANK3 JUND SCN8A

1.43e-0368963C0038220
DiseasecD177 antigen measurement

PSG6 PSG8

1.55e-0318962EFO_0021866
Diseasediastolic blood pressure, systolic blood pressure

FNDC3B ANK2 ANK3 MAP1B SPEG MET C2CD3 ALMS1

1.56e-03670968EFO_0006335, EFO_0006336
Diseaseapolipoprotein A 1 measurement

MAP1A RFX6 EYA1 FARP2 VIPAS39 LPL RIPOR1 R3HDM1 MGA

1.79e-03848969EFO_0004614
Diseaseelectroencephalogram measurement

FNDC3B E2F7 SH3BP4

1.83e-0374963EFO_0004357
Diseaseepilepsy (implicated_via_orthology)

ANK2 SCN2A SCN3A SCN8A

2.01e-03163964DOID:1826 (implicated_via_orthology)
Diseaseanxiety disorder (implicated_via_orthology)

SCN2A SCN3A

2.32e-0322962DOID:2030 (implicated_via_orthology)
DiseaseEpilepsy, Cryptogenic

PCDH19 SCN2A SCN8A

2.45e-0382963C0086237
DiseaseAwakening Epilepsy

PCDH19 SCN2A SCN8A

2.45e-0382963C0751111
DiseaseAura

PCDH19 SCN2A SCN8A

2.45e-0382963C0236018
DiseaseDyslipidemias

MACO1 LPL

2.76e-0324962C0242339
DiseaseDyslipoproteinemias

MACO1 LPL

2.76e-0324962C0598784

Protein segments in the cluster

PeptideGeneStartEntry
GLLTYKSPATSPISS

BIRC6

571

Q9NR09
KSTSVTYTPTIVPSS

VCAN

1576

P13611
TLPSSLSPSVEKYRY

DLG1

96

Q12959
FFPYVSPKTSITDSR

ALMS1

2446

Q8TCU4
SSSYAIEKKTPASLP

FAM186B

861

Q8IYM0
SPYVFSTTPESITEK

CCNB3

1056

Q8WWL7
PERSKPSDLASTYTV

R3HDM1

1041

Q15032
TLPTTVDYSSVPKQT

EBAG9

41

O00559
PTEESSINYTFKTPE

RANBP2

2601

P49792
YSLSSKTGTLLPEFP

RFX6

231

Q8HWS3
SLSPSKSYKYSPETP

RGPD5

786

Q99666
SLSPSKSYKYSPETP

RGPD8

786

O14715
SFVEKTVMPYISTTP

ITGB1

186

P05556
ETDLSIPTSPTSKYN

PARPBP

146

Q9NWS1
PVPETFSKYSSSIKV

RADX

511

Q6NSI4
PSSEEVSYEVTPKTT

ANK2

2541

Q01484
VSYEVTPKTTDVSTP

ANK2

2546

Q01484
LKSSLPTKPSVSYTI

PCDH19

1071

Q8TAB3
KLRSSSFVPSPYVAT

RB1CC1

1391

Q8TDY2
PTTYITTTDPKDTSS

MUC16

1321

Q8WXI7
STSPSKIVAPRNTTY

MUC16

2726

Q8WXI7
YISGTSPPSVEKTSS

MUC16

6496

Q8WXI7
ATKPSTVPYKALTSA

MUC16

9016

Q8WXI7
ELYSSSPGFSEPTKV

MUC16

9531

Q8WXI7
FKTTTTYPTPSHPQT

MUC6

1596

Q6W4X9
TKPLYSDTFFSLPIT

PTPRB

1596

P23467
ISPKSLQSDTPTFSY

MAP1A

2021

P78559
SYDISEKTTSPPEVS

MAP1B

1956

P46821
SPVVYQLPTKSTSYV

MGA

851

Q8IWI9
STIYTGYPLSPTKIS

HIPK1

1191

Q86Z02
PKTSLYEIPAVSSSS

IBTK

531

Q9P2D0
TTPTSSQFLYPKVAA

JUND

116

P17535
VSPHYSSKFVETSPS

MACO1

636

Q8N5G2
IPFTLPEVSTNKTYS

LPL

376

P06858
SYTSTPVTQKPVTTV

MUC3A

156

Q02505
PVTQKPVTTVTSTYS

MUC3A

161

Q02505
ALTEITPFSYISLPS

MUC3A

2751

Q02505
ARTSTTQPPKSFVYT

EVI2B

131

P34910
DITTTFPKDPVYTFS

NPLOC4

451

Q8TAT6
EYSTIHSPSTPIKDS

EYA1

276

Q99502
VSLPLLATDPSSFYS

NCKAP1L

1006

P55160
ATYPSEIPKEDSTTF

LMO7

836

Q8WWI1
PTPTYSATEDTFKDT

LRP2

4631

P98164
PEYVIQYTTSSKPSV

PARP12

671

Q9H0J9
QYTTSSKPSVTPSIL

PARP12

676

Q9H0J9
PTEESSINYTFKTPE

RGPD3

1626

A6NKT7
KTSRSTPLSPAYISL

KLHL13

21

Q9P2N7
VETSKSLIPIYSPFS

C2CD3

1781

Q4AC94
ARYPSYPLSTEKTTI

E2F7

156

Q96AV8
SFTFSKIPSPYTLSK

CAPN7

676

Q9Y6W3
FSETYTFSTTKSVPP

FNDC3B

1041

Q53EP0
SYPPEQTISTLKSYA

COL6A5

386

A8TX70
AAYPESKTPLTATLS

IGHA1

206

P01876
SALHPVSTPSKEYTS

DNAI7

261

Q6TDU7
DESKYTSAPSLPVSS

AKNAD1

481

Q5T1N1
YSSQSPTSSSPEKVL

ANK3

2621

Q12955
SKAVYSLISTPFSSE

DNAH14

2921

Q0VDD8
SYSIPSTSKQIVSPS

MAMLD1

261

Q13495
NKTISPKSTVYPIFS

ESCO2

316

Q56NI9
SRPVKPKFYLSSTTT

ITIH6

661

Q6UXX5
TFYIPSSSKRPCSAT

KRTAP16-1

376

A8MUX0
KSPLYLVSRSLPSSS

AHCTF1

1141

Q8WYP5
PTTASSYVDSALKPL

COG2

601

Q14746
PTSDFASPTYDLIKS

CUZD1

446

Q86UP6
SSSLTDPQVSYVKSP

FARP2

426

O94887
SPTKPYTSSSPILSD

CD34

156

P28906
LSTSETFYTFVILPK

OR10R2

86

Q8NGX6
VTFTSSYTPTPVTQK

MUC3B

151

Q9H195
LTEITPFSYISLPST

MUC3B

666

Q9H195
TFSYVDPVITSISPK

MET

651

P08581
EATTYTFSRAPSPTK

RTP1

211

P59025
TSTSYSPLASLPLKA

PLAGL1

306

Q9UM63
PVESQTTYTISFTPK

SAXO1

401

Q8IYX7
TTTKYPTFQDRPVSS

SH3BP4

641

Q9P0V3
DYSPAPSSTKSETRV

NCKAP5

946

O14513
YFTVTLYSETPKPSI

PSG6

136

Q00889
LYSETPKPSISSSNL

PSG6

141

Q00889
TLYLETPKPSISSSK

PSG8

141

Q9UQ74
ARPSSTITYLTDSPK

TMEM69

81

Q5SWH9
TTSPPFGKTTTVEYE

IBSP

246

P21815
SPYVTSYKSPVTTLD

SPESP1

171

Q6UW49
SNPSKVSYEPITTTL

SCN3A

1881

Q9NY46
ESEDSSYKPIFSTLP

SLF2

896

Q8IX21
KDDIYSPSSSSKIPV

SRMS

376

Q9H3Y6
ASSESSYLSILPKTP

PHLDB2

561

Q86SQ0
PPSVSYSILESVSKA

SVEP1

2086

Q4LDE5
YSFESSKFTRTISPP

EXO1

586

Q9UQ84
STDKAFVPYPEDTST

OMG

326

P23515
SITSKTYPPDLTSVF

TAS2R5

241

Q9NYW4
VVYSSSSVPDKSKPS

USP42

61

Q9H9J4
LKSISPSYKTLPSVS

TTC13

821

Q8NBP0
PSYKTLPSVSETFPT

TTC13

826

Q8NBP0
RYPSSISSSPQKDLT

UBAP2L

601

Q14157
KSVSRIPSETYSSSP

CD96

456

P40200
VKPVSSSTPVYVVTS

SPEG

2891

Q15772
SISPYPKTSSLESLN

SYCP2

1136

Q9BX26
SPRYSFSEDTKSPLS

SORBS1

461

Q9BX66
KATSTTELPPEYLTS

HGS

226

O14964
SNPSKVSYEPITTTL

SCN2A

1886

Q99250
SNPSKVSYEPITTTL

SCN8A

1876

Q9UQD0
TASLPSYDSVTKPEK

SCN8A

1941

Q9UQD0
SYAQLPKPTSTYSLS

VIPAS39

96

Q9H9C1
PLPSLKVKVYSSSTT

UNC5B

476

Q8IZJ1
KTTSGDERLYPSPTS

UBE3B

751

Q7Z3V4
VTKRFSTYSQSPPDT

RIPOR1

341

Q6ZS17
ITPTSNPSLTFEIYK

UGT2A1

61

P0DTE4
LDSSKSESPPYSFVV

ZFYVE26

1886

Q68DK2
LSEKSTTFYSSPRSP

MUC12

276

Q9UKN1
PTTPSLSEKSTTFYT

MUC12

1431

Q9UKN1
LSEKSTTFYTSPRSP

MUC12

1436

Q9UKN1
TPSLSEKSTTFYTSP

MUC12

2516

Q9UKN1
PSLSEKSTTFYTSPR

MUC12

2991

Q9UKN1
PTTPSLSEKSTTFYT

MUC12

4071

Q9UKN1
LSEKSTTFYTSPRSP

MUC12

4076

Q9UKN1
DSFFTPPSTPTKTTY

NACAD

171

O15069
SKEASSPPAVTPSTY

NACA

1576

E9PAV3
PQTIAPSTYVSTYLK

PPP1R12B

541

O60237