Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cellular response to corticosterone stimulus	FOXO3 NPAS4	3.67e-06	2	40	2	GO:0071386
MousePheno	epididymis epithelium degeneration	BMP8B BMP8A	1.52e-05	3	32	2	MP:0004934
Domain	Inhibin_asu	BMP8B BMP8A	2.94e-04	13	37	2	IPR002405
Domain	RCC1	HERC1 MYCBP2	7.09e-04	20	37	2	PF00415
Domain	RCC1_1	HERC1 MYCBP2	7.83e-04	21	37	2	PS00625
Domain	RCC1_2	HERC1 MYCBP2	7.83e-04	21	37	2	PS00626
Domain	RCC1_3	HERC1 MYCBP2	7.83e-04	21	37	2	PS50012
Domain	Reg_chr_condens	HERC1 MYCBP2	8.60e-04	22	37	2	IPR000408
Domain	GRAM	NCOA7 TBC1D8B	8.60e-04	22	37	2	PF02893
Domain	GRAM	NCOA7 TBC1D8B	8.60e-04	22	37	2	IPR004182
Domain	-	HERC1 MYCBP2	8.60e-04	22	37	2	2.130.10.30
Domain	RCC1/BLIP-II	HERC1 MYCBP2	9.41e-04	23	37	2	IPR009091
Domain	TGFb_propeptide	BMP8B BMP8A	1.40e-03	28	37	2	PF00688
Domain	TGF-b_N	BMP8B BMP8A	1.40e-03	28	37	2	IPR001111
Domain	TGF-beta-rel	BMP8B BMP8A	1.82e-03	32	37	2	IPR015615
Domain	TGFb_CS	BMP8B BMP8A	1.82e-03	32	37	2	IPR017948
Domain	TGFB	BMP8B BMP8A	2.43e-03	37	37	2	SM00204
Domain	TGF-b_C	BMP8B BMP8A	2.43e-03	37	37	2	IPR001839
Domain	TGF_BETA_2	BMP8B BMP8A	2.43e-03	37	37	2	PS51362
Domain	TGF_beta	BMP8B BMP8A	2.43e-03	37	37	2	PF00019
Domain	TGF_BETA_1	BMP8B BMP8A	2.43e-03	37	37	2	PS00250
Domain	Zinc_finger_PHD-type_CS	MLLT6 PHF8	7.34e-03	65	37	2	IPR019786
Domain	-	BMP8B BMP8A	7.79e-03	67	37	2	2.10.90.10
Domain	Cystine-knot_cytokine	BMP8B BMP8A	7.79e-03	67	37	2	IPR029034
Domain	PHD	MLLT6 PHF8	9.68e-03	75	37	2	PF00628
Domain	Znf_PHD-finger	MLLT6 PHF8	1.07e-02	79	37	2	IPR019787
Pubmed	Global comparative transcriptome analysis of cartilage formation in vivo.	BMP8B BMP8A ACAN	7.81e-07	16	40	3	19272164
Pubmed	Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.	BMP8B BMP8A	1.29e-06	2	40	2	31940275
Pubmed	Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.	BMP8B BMP8A	1.29e-06	2	40	2	9463357
Pubmed	The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	1.29e-06	2	40	2	8682296
Pubmed	A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling.	BPIFB4 NOS3	1.29e-06	2	40	2	28852218
Pubmed	The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.	BMP8B BMP8A	1.29e-06	2	40	2	21277400
Pubmed	NO production results in suspension-induced muscle atrophy through dislocation of neuronal NOS.	NOS3 SNTA1	3.87e-06	3	40	2	17786240
Pubmed	Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	3.87e-06	3	40	2	9076678
Pubmed	Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).	BMP8B BMP8A	3.87e-06	3	40	2	12925636
Pubmed	Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.	UBQLN2 ADRM1	3.87e-06	3	40	2	27396824
Pubmed	Requirement of Bmp8b for the generation of primordial germ cells in the mouse.	BMP8B BMP8A	3.87e-06	3	40	2	10894154
Pubmed	BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions.	BMP8B BMP8A	3.87e-06	3	40	2	22579288
Pubmed	Identification of targets of IL-13 and STAT6 signaling in polycystic kidney disease.	BICC1 STAT6	3.87e-06	3	40	2	29513071
Pubmed	Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis.	BMP8B BMP8A	3.87e-06	3	40	2	11784057
Pubmed	LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism.	BPIFB4 NOS3	3.87e-06	3	40	2	28419216
Pubmed	Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.	BMP8B BMP8A	3.87e-06	3	40	2	25451979
Pubmed	Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells.	BMP8B BMP8A	7.73e-06	4	40	2	9434160
Pubmed	Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development.	BMP8B BMP8A	7.73e-06	4	40	2	8843393
Pubmed	FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.	FOXO3 ACAN	7.73e-06	4	40	2	31980519
Pubmed	Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease.	BICC1 STAT6	7.73e-06	4	40	2	25922073
Pubmed	Proteasome subunit Rpn13 is a novel ubiquitin receptor.	UBQLN2 ADRM1	7.73e-06	4	40	2	18497817
Pubmed	FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.	FOXO3 ACAN	7.73e-06	4	40	2	29963746
Pubmed	Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation.	BMP8B BMP8A	1.93e-05	6	40	2	9878243
Pubmed	Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development.	BMP8B BMP8A	1.93e-05	6	40	2	7605753
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	SMS HERC1 HLA-DMB BICC1 ABCC10 ADGRA3 STAT6 AKR7A2	2.36e-05	1061	40	8	33845483
Pubmed	Tumour maintenance is mediated by eNOS.	FOXO3 NOS3	2.70e-05	7	40	2	18344980
Pubmed	Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis.	UBQLN2 ADRM1	2.70e-05	7	40	2	20059542
Pubmed	The Bmp8 gene is expressed in developing skeletal tissue and maps near the Achondroplasia locus on mouse chromosome 4.	BMP8B BMP8A	2.70e-05	7	40	2	9070944
Pubmed	Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.	UBQLN2 ADRM1	2.70e-05	7	40	2	30664872
Pubmed	Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.	BMP8B BMP8A	2.70e-05	7	40	2	12107726
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	NCOA7 TNKS1BP1 SMS UBQLN2 HERC1 AP2B1 ADRM1 POLD2 STAT6	3.24e-05	1455	40	9	22863883
Pubmed	Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b.	BMP8B BMP8A	4.62e-05	9	40	2	15028287
Pubmed	Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.	BMP8B BMP8A	4.62e-05	9	40	2	1460021
Pubmed	The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13.	UBQLN2 ADRM1	5.77e-05	10	40	2	25666615
Pubmed	Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor.	HERC1 MYCBP2 ADRM1	5.86e-05	65	40	3	28276505
Pubmed	Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein.	BMP8B BMP8A	7.05e-05	11	40	2	10721728
Pubmed	Bmp7 regulates germ cell proliferation in mouse fetal gonads.	BMP8B BMP8A	9.98e-05	13	40	2	18391523
Pubmed	New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.	BMP8B BMP8A	1.16e-04	14	40	2	11526197
Pubmed	Protein partners of C/EBPepsilon.	MLLT6 STAT6	1.16e-04	14	40	2	15588942
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TOGARAM1 TNKS1BP1 PHF8 MYCBP2	1.30e-04	225	40	4	12168954
Pubmed	Akt regulates skeletal development through GSK3, mTOR, and FoxOs.	FOXO3 ACAN	1.34e-04	15	40	2	19389373
Pubmed	Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.	FOXO3 SMS	1.34e-04	15	40	2	27572106
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	PPP1R3F SIX5 TBC1D8B STAT6	1.48e-04	233	40	4	37704626
Pubmed	Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice.	IGFBP2 STAT6	1.73e-04	17	40	2	9175833
Pubmed	Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.	BMP8B BMP8A	1.73e-04	17	40	2	14736746
Pubmed	Dysfunction of programmed embryo senescence is linked to genetic developmental defects.	BMP8B BMP8A	1.95e-04	18	40	2	37017267
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	AP2B1 ACAN BICC1	2.11e-04	100	40	3	25807483
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOXO3 MLLT6 BMP8B TNKS1BP1 HERC1 MYCBP2 ABCC10	2.39e-04	1105	40	7	35748872
Pubmed	The Role of Bmp2 in the Maturation and Maintenance of the Murine Knee Joint.	IGFBP2 ACAN	2.42e-04	20	40	2	29665134
Pubmed	Genetic link between renal birth defects and congenital heart disease.	AP2B1 BICC1	4.78e-04	28	40	2	27002738
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DCHS2 NUP58 UBQLN2 AP2B1 MYCBP2 SNTA1 STAT6	5.92e-04	1285	40	7	35914814
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	TNKS1BP1 UBQLN2 AP2B1 MYCBP2 ADRM1 POLD2 AKR7A2	6.26e-04	1297	40	7	33545068
Pubmed	RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.	SIX5 IGFBP2	6.26e-04	32	40	2	20111592
Pubmed	Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes.	UBQLN2 ADRM1	6.26e-04	32	40	2	19815544
Pubmed	Forkhead box a2 (FOXA2) is essential for uterine function and fertility.	BMP8B BMP8A	6.66e-04	33	40	2	28049832
Pubmed	Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis.	BMP8B BMP8A	6.66e-04	33	40	2	32640236
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	TNKS1BP1 UBQLN2 MYCBP2 SNTA1	6.70e-04	347	40	4	17114649
Pubmed	Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes.	UBQLN2 ADRM1	1.03e-03	41	40	2	32723828
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	TNKS1BP1 UBQLN2 POLD2 LACTB AKR7A2	1.09e-03	686	40	5	28380382
Cytoband	Xq22.3	AMMECR1 TBC1D8B	3.84e-04	33	40	2	Xq22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr20q11	BPIFB4 ARHGAP40 SNTA1	1.33e-03	248	40	3	chr20q11
Cytoband	Ensembl 112 genes in cytogenetic band chrXp11	PPP1R3F UBQLN2 PHF8	4.33e-03	377	40	3	chrXp11
Cytoband	Ensembl 112 genes in cytogenetic band chr15q22	HERC1 LACTB	5.96e-03	132	40	2	chr15q22
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	MLLT6 AP2B1	7.53e-03	149	40	2	chr17q12
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP8B BMP8A	1.45e-04	11	30	2	455
GeneFamily	PHD finger proteins	MLLT6 PHF8	9.74e-03	90	30	2	88
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1-Excitatory_Neuron.Slc17a7.Parm1.Fos_(Deep_layer_pyramidal_cells--layer_5_(IEG))\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DCHS2 AP5B1 NPAS4 CDH15	6.91e-07	77	40	4	4879a1a72b950dadb78bc0312be75f1a32b935d5
ToppCell	facs-Heart-RV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3F BMP8B HLA-DMB AP5B1	1.69e-05	172	40	4	2dcc9d67d6ecc35940eabbc8ed528f5f884f6976
ToppCell	facs-Heart-RV-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3F BMP8B HLA-DMB AP5B1	1.69e-05	172	40	4	64d2edbd8e2640b76225597883b1a524e6b1dd3b
ToppCell	facs-Heart-RV-18m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP1R3F BMP8B HLA-DMB AP5B1	1.69e-05	172	40	4	d061ea21bee179df5a525842e9a48621a8e1461b
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	NCOA7 NUP58 AP2B1 LACTB	2.60e-05	192	40	4	4e689bca7a242f8482e25f273656e2caba8821c0
ToppCell	18-Airway\|18 / Age, Tissue, Lineage and Cell class	NCOA7 IGFBP2 ACAN BICC1	2.94e-05	198	40	4	3cdfcc6445858c3c54058bbd90b20b88b1771cca
Disease	Eczema, allergic rhinitis	HLA-DMB NOS3 AP5B1 STAT6	2.04e-04	215	40	4	EFO_0005854, HP_0000964
Disease	Alzheimer's disease (is_marker_for)	FOXO3 IGFBP2 NOS3 AKR7A2	4.02e-04	257	40	4	DOID:10652 (is_marker_for)
Disease	diabetes mellitus (implicated_via_orthology)	BMP8B BMP8A	5.70e-04	26	40	2	DOID:9351 (implicated_via_orthology)
Disease	sexual dimorphism measurement	FOXO3 BMP8A HERC1 ACAN SNTA1 AP5B1 NPAS4	6.44e-04	1106	40	7	EFO_0021796
Disease	resting heart rate, chronic obstructive pulmonary disease	BMP8A HERC1	7.61e-04	30	40	2	EFO_0000341, EFO_0004351
Disease	Chronic Obstructive Airway Disease	FOXO3 NOS3	9.21e-04	33	40	2	C0024117
Disease	Chronic Airflow Obstruction	FOXO3 NOS3	9.21e-04	33	40	2	C1527303
Disease	childhood onset asthma	PPP1R3F HLA-DMB AP5B1 STAT6	1.07e-03	334	40	4	MONDO_0005405
Disease	prostate cancer (is_marker_for)	FOXO3 PHF8 STAT6	1.24e-03	156	40	3	DOID:10283 (is_marker_for)
Disease	Cleft upper lip	PHF8 NOS3	1.29e-03	39	40	2	C0008924
Disease	Diuretic use measurement	NOS3 BICC1 ABCC10	1.56e-03	169	40	3	EFO_0009928
Disease	Obesity	FOXO3 IGFBP2 LACTB	2.70e-03	205	40	3	C0028754
Disease	Calcium channel blocker use measurement	NOS3 BICC1 ABCC10	3.01e-03	213	40	3	EFO_0009930
Disease	Insulin Sensitivity	IGFBP2 NOS3	3.02e-03	60	40	2	C0920563
Disease	Insulin Resistance	IGFBP2 NOS3	3.02e-03	60	40	2	C0021655

Protein segments in the cluster

Peptide	Gene	Start	Entry
AEGLLGGLAGSGGLP	MLLT6	881	P55198
GGLAGSGGLPLNGLL	MLLT6	886	P55198
SGGLPLNGLLGGLNG	MLLT6	891	P55198
QSETILGGLGLGLGG	AKR7A2	81	O43488
GAVDLLGGGLDSLVG	AP2B1	651	P63010
LLGDGGLLGGGGVLG	BPIFB4	196	P59827
LLALLALLGGGGGGG	ADGRA3	21	Q8IWK6
ASAGLGLTGLGLLGP	BICC1	446	Q9H694
LDGELGEGGRSLSLG	ABCC10	1371	Q5T3U5
GILSGNDGGLLSGSE	KRT12	111	Q99456
VGGLGLGLGLALGVK	LACTB	41	P83111
SSDGLALVSGGLGGL	HERC1	3756	Q15751
VLLVSGLGLGGGGGE	POLD2	196	P49005
LLLLLGASGGGGGAR	IGFBP2	21	P18065
GGSLGLLRGLLGQEG	AP5B1	166	Q2VPB7
TEGLGLGGLLGNGAV	MRGPRE	31	Q86SM8
GFGDLSGLPSGGEGL	ACAN	1541	P16112
GLGLGLGLGLCGKQG	NOS3	16	P29474
GLGDGSISLSLEGGE	DCHS2	461	Q6V1P9
SAEAGTGGLEPLGGL	NPAS4	651	Q8IUM7
PLLLGLSLGCTGAGG	HLA-DMB	6	P28068
LGLTLCALGGGGPGL	BMP8A	11	Q7Z5Y6
LGLALCALGGGGPGL	BMP8B	11	P34820
GAAALLAGGTGLSLG	CDH15	591	P55291
STGLSLGGALAGLGG	NUP58	166	Q9BVL2
GGGGSGTLGSGLLLE	FOXO3	81	O43524
GKDVLILGGGDGGIL	SMS	191	P52788
GLLELRAGAGSGAGG	SNTA1	11	Q13424
NGDISSLELGGGGGR	NCOA7	886	Q8NI08
GEASSLGPLLLTGGG	SIX5	351	Q8N196
DILLGGLGLFGGRGE	MYCBP2	1261	O75592
GGLGALTGPGLASLL	ADRM1	181	Q16186
AGELGLGGAGTRLNG	AMMECR1	41	Q9Y4X0
LGGAGTRLNGLGGLT	AMMECR1	46	Q9Y4X0
TGLSGLLGGLGLDGD	ARHGAP40	71	Q5TG30
EEGGGGLTGLLVGTL	TBC1D8B	36	Q0IIM8
LLEGQGESGGGSLGA	STAT6	806	P42226
SGLGGLLEEEGAGAG	TNKS1BP1	1476	Q9C0C2
GGGLEAVSGSEELLG	PPP1R3F	466	Q6ZSY5
GKLGNGSGAGGILDL	PHF8	716	Q9UPP1
GSLGGLAGLSSLGLS	UBQLN2	146	Q9UHD9
GGGLSGGDEEDTRLL	TOGARAM1	86	Q9Y4F4
GVLDGATELLGLGGL	ZMYM3	71	Q14202