Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1B

3.15e-049602GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1B

3.15e-049602GO:0099626
GeneOntologyMolecularFunctionDNA/DNA annealing activity

SMARCAL1 RECQL

4.80e-0411602GO:1990814
GeneOntologyMolecularFunctionsingle-stranded DNA binding

DHX36 SMARCAL1 RECQL XPC

7.07e-04134604GO:0003697
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1B

7.89e-0414602GO:0008331
GeneOntologyMolecularFunctionannealing activity

SMARCAL1 RECQL

7.89e-0414602GO:0140666
DomainTF_fork_head_CS_2

FOXB1 FOXD4L4 FOXD4L3 FOXB2 FOXD4L6 FOXC1 FOXD4L5

1.19e-1046607IPR030456
DomainTF_fork_head_CS_1

FOXB1 FOXD4L4 FOXD4L3 FOXB2 FOXD4L6 FOXC1 FOXD4L5

1.40e-1047607IPR018122
DomainFH

FOXB1 FOXD4L4 FOXD4L3 FOXB2 FOXD4L6 FOXC1 FOXD4L5

1.90e-1049607SM00339
DomainFORK_HEAD_1

FOXB1 FOXD4L4 FOXD4L3 FOXB2 FOXD4L6 FOXC1 FOXD4L5

1.90e-1049607PS00657
DomainFORK_HEAD_2

FOXB1 FOXD4L4 FOXD4L3 FOXB2 FOXD4L6 FOXC1 FOXD4L5

1.90e-1049607PS00658
DomainFork_head_dom

FOXB1 FOXD4L4 FOXD4L3 FOXB2 FOXD4L6 FOXC1 FOXD4L5

1.90e-1049607IPR001766
DomainFORK_HEAD_3

FOXB1 FOXD4L4 FOXD4L3 FOXB2 FOXD4L6 FOXC1 FOXD4L5

1.90e-1049607PS50039
DomainForkhead

FOXB1 FOXD4L4 FOXD4L3 FOXB2 FOXD4L6 FOXC1 FOXD4L5

1.90e-1049607PF00250
Domain-

FOXB1 FOXD4L4 FOXD4L3 FOXB2 RECQL FOXD4L6 FOXC1 FOXD4L5

4.60e-072186081.10.10.10
DomainWHTH_DNA-bd_dom

FOXB1 FOXD4L4 FOXD4L3 FOXB2 RECQL FOXD4L6 FOXC1 FOXD4L5

1.01e-06242608IPR011991
DomainMyotonic_dystrophy_kinase_coil

CDC42BPG CDC42BPB

6.06e-054602IPR014930
DomainMyotonic_dystrophy_kinase_coil

CDC42BPG CDC42BPB

6.06e-054602PD011252
DomainDMPK_coil

CDC42BPG CDC42BPB

6.06e-054602PF08826
DomainVDCC_a1su_IQ

CACNA1A CACNA1B

2.11e-047602IPR014873
DomainGPHH

CACNA1A CACNA1B

2.11e-047602PF16905
DomainGPHH_dom

CACNA1A CACNA1B

2.11e-047602IPR031649
DomainCa_chan_IQ

CACNA1A CACNA1B

2.11e-047602SM01062
DomainCa_chan_IQ

CACNA1A CACNA1B

2.11e-047602PF08763
DomainPkinase_C

CDC42BPG RPS6KA2 CDC42BPB

2.27e-0437603IPR017892
DomainPkinase_C

CDC42BPG RPS6KA2 CDC42BPB

3.31e-0442603PF00433
DomainHelicase_C

DHX36 SMARCAL1 RECQL DDX60L

3.88e-04107604PF00271
DomainHELICc

DHX36 SMARCAL1 RECQL DDX60L

3.88e-04107604SM00490
DomainHelicase_C

DHX36 SMARCAL1 RECQL DDX60L

4.02e-04108604IPR001650
DomainHELICASE_CTER

DHX36 SMARCAL1 RECQL DDX60L

4.16e-04109604PS51194
DomainHELICASE_ATP_BIND_1

DHX36 SMARCAL1 RECQL DDX60L

4.16e-04109604PS51192
DomainDEXDc

DHX36 SMARCAL1 RECQL DDX60L

4.16e-04109604SM00487
DomainHelicase_ATP-bd

DHX36 SMARCAL1 RECQL DDX60L

4.31e-04110604IPR014001
DomainVDCCAlpha1

CACNA1A CACNA1B

4.49e-0410602IPR002077
DomainAGC-kinase_C

CDC42BPG RPS6KA2 CDC42BPB

7.74e-0456603IPR000961
DomainAGC_KINASE_CTER

CDC42BPG RPS6KA2 CDC42BPB

7.74e-0456603PS51285
DomainS_TK_X

CDC42BPG RPS6KA2 CDC42BPB

7.74e-0456603SM00133
DomainChannel_four-helix_dom

CACNA1A CACNA1B SCN11A

8.15e-0457603IPR027359
Domain-

CACNA1A CACNA1B SCN11A

8.15e-04576031.20.120.350
DomainCNH

CDC42BPG CDC42BPB

9.01e-0414602SM00036
DomainCNH

CDC42BPG CDC42BPB

1.04e-0315602PF00780
DomainCNH

CDC42BPG CDC42BPB

1.04e-0315602PS50219
DomainCNH_dom

CDC42BPG CDC42BPB

1.04e-0315602IPR001180
DomainPBD

CDC42BPG CDC42BPB

1.34e-0317602PF00786
DomainP-loop_NTPase

DHX36 SAMD9L ABCA6 UCKL1 SMARCAL1 KIF16B ABCB11 RECQL DDX60L

1.45e-03848609IPR027417
DomainDEAD/DEAH_box_helicase_dom

DHX36 RECQL DDX60L

1.67e-0373603IPR011545
DomainDEAD

DHX36 RECQL DDX60L

1.67e-0373603PF00270
DomainCRIB

CDC42BPG CDC42BPB

1.86e-0320602PS50108
DomainCRIB_dom

CDC42BPG CDC42BPB

2.05e-0321602IPR000095
DomainG_patch

CHERP RBM6

2.46e-0323602SM00443
DomainG_patch_dom

CHERP RBM6

2.46e-0323602IPR000467
DomainSpectrin

TRIO ACTN3

2.46e-0323602PF00435
DomainG_PATCH

CHERP RBM6

2.46e-0323602PS50174
DomainG-patch

CHERP RBM6

2.46e-0323602PF01585
Domain-

DHX36 SAMD9L ABCA6 UCKL1 SMARCAL1 ABCB11 RECQL DDX60L

2.54e-037466083.40.50.300
Domain-

CHERP HIP1R

3.14e-03266021.25.40.90
Pubmed

Six members of the mouse forkhead gene family are developmentally regulated.

FOXB1 FOXD4L4 FOXD4L3 FOXB2 FOXD4L6 FOXC1 FOXD4L5

2.01e-16156077689224
Pubmed

Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.

FOXB1 FOXD4L4 FOXD4L3 FOXB2 FOXD4L6 FOXD4L5

1.61e-13166068861101
Pubmed

Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

FOXD4L4 FOXD4L3 FOXD4L6 FOXC1 FOXD4L5

1.64e-11136057957066
Pubmed

FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.

FOXD4L4 FOXD4L6 FOXC1 FOXD4L5

4.00e-11560412234674
Pubmed

Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.

FOXD4L4 FOXD4L3 FOXD4L6 FOXC1 FOXD4L5

5.55e-111660510208738
Pubmed

Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

1.20e-10660427092474
Pubmed

The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

5.57e-1086048530406
Pubmed

An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

1.00e-09960412412011
Pubmed

A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

5.65e-091360416884697
Pubmed

Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

1.08e-081560422045912
Pubmed

Functional equivalency between Otx2 and Otx1 in development of the rostral head.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

3.04e-08196049895322
Pubmed

Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

3.80e-082060412812790
Pubmed

Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

4.68e-08216049449667
Pubmed

Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

5.72e-082260417389379
Pubmed

Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

8.28e-082460411820816
Pubmed

A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

8.28e-082460429992973
Pubmed

Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

1.16e-072660415857913
Pubmed

Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

1.84e-072960422972626
Pubmed

EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers.

EZH2 FOXC1

2.93e-06260233057161
Pubmed

Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.

CACNA1A CACNA1B

2.93e-06260223426690
Pubmed

FOXC1 transcriptionally suppresses ABHD5 to inhibit the progression of renal cell carcinoma through AMPK/mTOR pathway.

ABHD5 FOXC1

2.93e-06260239093497
Pubmed

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

CACNA1A CACNA1B

2.93e-06260223376566
Pubmed

Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program.

EZH2 FOXC1

2.93e-06260229959321
Pubmed

CaV 2.1 α1  subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.

CACNA1A CACNA1B

2.93e-06260238155373
Pubmed

Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.

CACNA1A CACNA1B

2.93e-06260215050706
Pubmed

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.

ACTN3 EYA1 EZH2

5.45e-062060322267199
Pubmed

Genome-scale study of transcription factor expression in the branching mouse lung.

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

5.65e-066760422711520
Pubmed

Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.

CACNA1A CACNA1B

8.77e-06360229466725
Pubmed

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.

CACNA1A CACNA1B

8.77e-06360224394417
Pubmed

EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2.

SMARCAL1 RECQL

8.77e-06360231255466
Pubmed

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

CACNA1A CACNA1B

8.77e-06360238996073
Pubmed

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD).

RAG1 EZH2

8.77e-06360227909059
Pubmed

The Heteromeric Complex Formed by Dopamine Receptor D5 and CCR9 Leads the Gut Homing of CD4+ T Cells Upon Inflammation.

RAG1 DRD5

8.77e-06360233864900
Pubmed

Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

CACNA1A CACNA1B

8.77e-06360224523520
Pubmed

Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.

CACNA1A CACNA1B

8.77e-06360229208674
Pubmed

Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

CACNA1A CACNA1B

8.77e-06360226507659
Pubmed

Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.

CACNA1A CACNA1B

1.75e-05460232616470
Pubmed

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.

CACNA1A CACNA1B

1.75e-05460226283199
Pubmed

Leucine zipper transcription factor-like 1 (LZTFL1), an intraflagellar transporter protein 27 (IFT27) associated protein, is required for normal sperm function and male fertility.

ABHD5 LZTFL1

1.75e-05460234023333
Pubmed

A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.

CACNA1A CACNA1B

1.75e-05460215728831
Pubmed

The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.

CACNA1A CACNA1B

1.75e-05460225483588
Pubmed

Cerebellar granule cell signaling is indispensable for normal motor performance.

CACNA1A CACNA1B

1.75e-05460237141091
Pubmed

Interactions of Rabconnectin-3 with Cav2 calcium channels.

CACNA1A CACNA1B

1.75e-05460231253182
Pubmed

Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

RAG1 EZH2

1.75e-05460229438697
Pubmed

G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.

CACNA1A CACNA1B

1.75e-05460215953418
Pubmed

Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.

CACNA1A CACNA1B

2.92e-0556028825650
Pubmed

MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme.

FOXB1 FOXC1

2.92e-0556028325367
Pubmed

Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.

CACNA1A CACNA1B

2.92e-05560216787652
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1A CACNA1B

2.92e-05560215451373
Pubmed

Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines.

MYOZ2 ACTN3

2.92e-05560211171996
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1A CACNA1B

2.92e-05560211296258
Pubmed

Deletion of Vβ3+CD4+ T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T cells.

ST6GALNAC1 RAG1

4.37e-05660238015847
Pubmed

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.

FOXB1 FOXC1

4.37e-0566028375339
Pubmed

An action potential initiation mechanism in distal axons for the control of dopamine release.

CACNA1A CACNA1B

4.37e-05660235324301
Pubmed

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.

CACNA1A CACNA1B

4.37e-05660212827191
Pubmed

Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.

CACNA1A CACNA1B

4.37e-0566029238069
Pubmed

beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.

CACNA1A CACNA1B

4.37e-05660210328888
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

HJURP SPIRE1 SIPA1L2 EZH2 FOXC1

5.12e-0523260525515538
Pubmed

The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity.

EYA1 EZH2

6.11e-05760221936910
Pubmed

Rebuilding essential active zone functions within a synapse.

CACNA1A CACNA1B

6.11e-05760235176221
Pubmed

MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.

CDC42BPG CDC42BPB

6.11e-05760229162624
Pubmed

CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8+ T cells in diabetic autoimmunity.

RAG1 CCRL2

6.11e-05760238754432
Pubmed

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability.

RAG1 OCLN

8.14e-05860226431948
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

FOXB1 FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

9.26e-0526360520932939
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DHX36 PTPN12 SPTLC2 GARS1 HIP1R RECQL XPC DDX60L NOL9 ZC3HAV1

9.84e-051353601029467282
Pubmed

P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.

CACNA1B RPS6KA2

1.05e-04960219555761
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1B

1.05e-04960216382099
Pubmed

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

MYOZ2 ACTN3

1.05e-04960211114196
Pubmed

A protein interaction landscape of breast cancer.

TRIO SPTLC2 GARS1 HIP1R XPC EZH2 ZC3HAV1

1.08e-0463460734591612
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

STOX2 TRIO RPS6KA2 HJURP SPIRE1 CEP152 SIPA1L2 ZC3HAV1

1.12e-0486160836931259
Pubmed

The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development.

FOXB1 FOXC1

1.31e-04106028661058
Pubmed

Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.

FOXB1 FOXB2 EZH2

1.34e-045760321122108
Pubmed

Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.

FOXD4L4 FOXD4L3

1.59e-041160212421752
Pubmed

Sonic hedgehog regulation of Foxf2 promotes cranial neural crest mesenchyme proliferation and is disrupted in cleft lip morphogenesis.

FOXB2 FOXC1

1.59e-041160228506991
Pubmed

Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.

RPS6KA2 ACTN3

1.59e-041160216585392
Pubmed

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.

FOXB1 FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

1.88e-0430660518973680
Pubmed

Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.

CACNA1A CACNA1B

2.63e-041460221228161
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1A CACNA1B

3.03e-041560220188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1A CACNA1B

3.03e-041560224453333
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

RPS6KA2 POLR2D RBM6 RECQL XPC NOL9

3.13e-0453360625544563
Pubmed

Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain.

FOXB1 FOXB2

3.46e-041660216376864
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

DHX36 GARS1 HJURP NOL9 ZC3HAV1

4.16e-0436460524778252
Pubmed

Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.

POLM POLR2D XPC

4.21e-048460319237606
Pubmed

Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3.

LZTFL1 CCRL2

4.40e-041860212461651
Pubmed

PTEN identified as important risk factor of chronic obstructive pulmonary disease.

RAG1 ABCA6 ABCB11 XPC FOXC1

4.71e-0437460519625176
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

PTPN12 TRIO CEP152 SIPA1L2

4.75e-0420960436779422
Pubmed

The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis.

RECQL FOXC1

4.91e-041960211562355
Pubmed

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.

RAG1 ABCA6 ABCB11 XPC FOXC1

5.12e-0438160518676680
Pubmed

Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

RAG1 ABCA6 ABCB11 XPC FOXC1

5.18e-0438260519170196
Pubmed

ATRX proximal protein associations boast roles beyond histone deposition.

XPC NOL9 EZH2

5.32e-049160334780483
Pubmed

N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

SAMD9L POLM SMARCAL1 HIP1R

5.47e-0421760434048709
Pubmed

Genome-wide association study of intelligence: additive effects of novel brain expressed genes.

TUSC3 KIF16B

6.02e-042160222449649
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

PTPN12 CHERP XPC SIPA1L2 EZH2

6.10e-0439660526687479
Pubmed

Diverse fates of paralogs following segmental duplication of telomeric genes.

FOXD4L4 FOXD4L3

6.61e-042260215233989
Pubmed

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.

PTPN12 TRIO HIP1R CDC42BPB

6.80e-0423060435449600
Pubmed

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

CACNA1A CACNA1B

7.88e-042460222534482
Pubmed

Genetic susceptibility to distinct bladder cancer subphenotypes.

RAG1 ABCA6 ABCB11 XPC FOXC1

8.02e-0442160519692168
Pubmed

Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis.

EYA1 FOXC1

8.56e-042560222511595
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

DHX36 CHERP RBM6 RECQL NOL9 ZC3HAV1

9.07e-0465360622586326
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CDC42BPG TRIO UCKL1 RPS6KA2 TUSC3 RBM6 SPIRE1 CDC42BPB ZC3HAV1

9.73e-04148960928611215
InteractionANKFY1 interactions

TRIO KIF16B CEP152 OCLN SIPA1L2 EZH2 ZC3HAV1

5.00e-06236587int:ANKFY1
InteractionNALCN interactions

CACNA1A CACNA1B SCN11A

8.05e-0614583int:NALCN
InteractionSCN11A interactions

CACNA1A CACNA1B SCN11A

1.00e-0515583int:SCN11A
InteractionSCN9A interactions

CACNA1A CACNA1B SCN11A

2.90e-0521583int:SCN9A
InteractionPTGES3 interactions

DHX36 UCKL1 RPS6KA2 SMARCAL1 HJURP DDX60L NOL9 CDC42BPB

3.40e-05437588int:PTGES3
InteractionCACNA1D interactions

CACNA1A CACNA1B SCN11A

4.39e-0524583int:CACNA1D
InteractionCACNB1 interactions

CACNA1A CACNA1B EYA1

4.97e-0525583int:CACNB1
InteractionSCN1A interactions

CACNA1A CACNA1B SCN11A

7.84e-0529583int:SCN1A
Cytoband9q21.11

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

7.04e-08306049q21.11
CytobandEnsembl 112 genes in cytogenetic band chr9q21

FOXD4L4 FOXD4L3 FOXB2 FOXD4L5

1.38e-04199604chr9q21
CytobandEnsembl 112 genes in cytogenetic band chr3p21

ABHD5 LZTFL1 RBM6 CCRL2

7.93e-04316604chr3p21
Cytoband3p21

ABHD5 CCRL2

8.64e-04336023p21
GeneFamilyForkhead boxes

FOXB1 FOXB2 FOXC1

1.25e-0443413508
GeneFamilyG-patch domain containing|Minor histocompatibility antigens

CHERP RBM6

1.13e-0322412579
GeneFamilyCalcium voltage-gated channel subunits

CACNA1A CACNA1B

1.58e-0326412253
CoexpressionMIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3

FOXB1 FOXD4L4 FOXD4L3 FOXD4L6 OCLN FOXD4L5

1.04e-05217606MM861
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#2_top-relative-expression-ranked_1000

RPS6KA2 CEP152 ACTN3 EYA1 FOXC1

3.41e-0689555gudmap_developingKidney_e11.5_metaneph mesench_1000_k2
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#4_top-relative-expression-ranked_100

ACTN3 EYA1 FOXC1

3.20e-0524553gudmap_developingKidney_e11.5_metaneph mesench_100_k4
ToppCell(05)_Ciliated-(2)_48hpi|(05)_Ciliated / shred by cell type and Timepoint

SCN11A KIF16B ABCB11 RECQL COL6A5

7.09e-07124605fc8cce8c1809edafbc4e69e501dd4f016f5dfc0b
ToppCellmild-Myeloid-Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SAMD9L SPTLC2 DDX60L SIPA1L2 ZC3HAV1

6.70e-06196605ded44b38ea489946e9eedfe752b5a9fde9149c16
ToppCellBAL-Mild-cDC_1|Mild / Compartment, Disease Groups and Clusters

SAMD9L SPTLC2 CCRL2 DDX60L ZC3HAV1

7.22e-06199605c55181bdec8952b54198f0d4c9c5c84265b16572
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PTPN12 SAMD9L SPTLC2 RPS6KA2 SIPA1L2

7.39e-062006052d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANO4 ABCA6 SMARCAL1 COL6A5

3.22e-0513460464979e1a056b7406e1be39c5ebe2f8d731ac3c17
ToppCellBAL-Control-cDC_1|Control / Compartment, Disease Groups and Clusters

SAMD9L DDX60L FOXC1 ZC3HAV1

9.51e-05177604aa021f6d62e9d740c5ea499faaf875de835a2865
ToppCellwk_15-18-Hematologic-Myeloid-aDC_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FOXD4L4 FOXD4L3 FOXD4L6 FOXD4L5

9.51e-05177604ccf5dc54780d6039a4d062dee88440c011ddc0a3
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 SPTLC2 EYA1 FOXC1

9.51e-05177604da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

SAMD9L TRIO DDX60L ZC3HAV1

1.08e-041836048f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 SPTLC2 EYA1 FOXC1

1.10e-04184604da06ff24ee2b2cf4715fdfce43030b2da9e0aaf8
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ST6GALNAC1 SAMD9L CCRL2 FOXC1

1.10e-041846049001d35cdde061d06f8545b3cee942d1299129db
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial-Endo_L2-5_CLDN5|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ST6GALNAC1 SAMD9L CCRL2 FOXC1

1.10e-0418460473eaac74a88bf5fd23d88035fac398ac43b268c5
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Endothelial_Myeloid-Endo|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ST6GALNAC1 SAMD9L CCRL2 FOXC1

1.10e-0418460465f651d4b93ed0b52f526d3f517d92b6c62aaec3
ToppCellThalamus-Endothelial|Thalamus / BrainAtlas - Mouse McCarroll V32

SAMD9L CCRL2 FOXC1 ZC3HAV1

1.15e-04186604dcc6e4417c4123d5ca6b96fa8ca4874626aaebdb
ToppCellfacs-Heart-RA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 EYA1 OCLN FOXC1

1.20e-041886044ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCellfacs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 EYA1 OCLN FOXC1

1.20e-04188604e47e66906922d5c69b1aafe28face0787d3fc563
ToppCellMacrophages-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

SAMD9L POLR2D DDX60L SIPA1L2

1.22e-04189604c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 EYA1 OCLN FOXC1

1.22e-041896048e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 EYA1 OCLN FOXC1

1.22e-041896041137583e21d874c201c20581ba1995e2bfa3de59
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 EYA1 OCLN FOXC1

1.22e-04189604fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

STOX2 MYOZ2 DDX60L EYA1

1.25e-0419060493c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCelldroplet-Heart-nan-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 EYA1 OCLN FOXC1

1.25e-041906047068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCellfacs-Heart-RV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 EYA1 OCLN FOXC1

1.27e-04191604e518c598719119e60c76016c586b1520c258bbcb
ToppCellfacs-Heart-RV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 EYA1 OCLN FOXC1

1.27e-04191604f0c649bb32732c9dd38a0af8ce94d2a4d16de39a
ToppCellfacs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 EYA1 OCLN FOXC1

1.30e-0419260414a816ef116aa992f86edab411f043cf7d07fe04
ToppCellfacs-Heart-LA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS6KA2 EYA1 OCLN FOXC1

1.30e-04192604847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical|TCGA-Thryoid / Sample_Type by Project: Shred V9

CDC42BPG BMP1 TUSC3 SIPA1L2

1.35e-04194604b46c54802b8d1e0a0a17f9ed8e82eaf5e7f4849d
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

CACNA1A SAMD9L SPTLC2 DDX60L

1.38e-04195604b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellControl-Myeloid-TRAM3|Control / Disease group,lineage and cell class (2021.01.30)

SAMD9L EDEM2 CCRL2 DDX60L

1.44e-04197604733ff40039d67e561c2ded7c9bd0b4353101741e
ToppCellBAL-Control-Myeloid-TRAM-TRAM3-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9L EDEM2 CCRL2 DDX60L

1.44e-041976040f1c4a328968b32874e6ebb0803e665adcbbc450
ToppCellBAL-Control-Myeloid-TRAM-TRAM3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SAMD9L EDEM2 CCRL2 DDX60L

1.44e-04197604aafe0cd697b0b7f0756596148e0906443fdf8ef7
ToppCellBAL-Control-Myeloid-TRAM-TRAM3-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SAMD9L EDEM2 CCRL2 DDX60L

1.44e-04197604e131634bc67e0bd31a938a8e8df8dc752e1d0f47
ToppCellBAL-Control-Myeloid-TRAM-TRAM3|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

SAMD9L EDEM2 CCRL2 DDX60L

1.44e-041976044416efdbd9c4ac3356a5dff2d535c2d7383376a9
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SAMD9L ABHD5 DDX60L SIPA1L2

1.46e-04198604e125eb8aa57c172e5518874da1bd25998292f5e2
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SAMD9L ABHD5 DDX60L SIPA1L2

1.46e-041986040baeb8e2c199ff10bb5c829c523546af3c9227c1
ToppCellTCGA-Colorectal-Primary_Tumor|TCGA-Colorectal / Sample_Type by Project: Shred V9

POLR2D GARS1 HJURP EZH2

1.49e-04199604c7d6a8398f2419b726a0461585d1ee0561654e3b
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

POLR2D GARS1 HJURP EZH2

1.49e-0419960485b3b1ad01368dae4adbc9da7efc148e49992f69
Drug4-aminopiperidine

CACNA1A CACNA1B DRD5

2.83e-0611603CID000424361
Druggeldanamycin; Down 200; 1uM; MCF7; HT_HG-U133A_EA

PTPN12 TRIO SPTLC2 SMARCAL1 HIP1R FOXC1

9.81e-06187606972_DN
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1B

1.02e-053552DOID:0111181 (implicated_via_orthology)
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1B

2.04e-054552DOID:6364 (implicated_via_orthology)
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1B

7.12e-057552DOID:0050951 (implicated_via_orthology)
Diseasemacrophage inflammatory protein 1b measurement

ABHD5 LZTFL1 CCRL2 NOL9

1.23e-04136554EFO_0008219
Diseasecerebral cavernous malformation (implicated_via_orthology)

CDC42BPG CDC42BPB

1.86e-0411552DOID:0060669 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

CACNA1A CACNA1B SCN11A TRIO

2.46e-04163554DOID:1826 (implicated_via_orthology)
DiseaseS-adenosylhomocysteine measurement

ANO4 CACNA1B

4.56e-0417552EFO_0010531
Diseaseresponse to paliperidone, schizophrenia symptom severity measurement

ANO4 CACNA1B SPTLC2 TUSC3

7.11e-04216554EFO_0007925, EFO_0007927
Diseaseobsolete_red blood cell distribution width

ABCA6 SPTLC2 GARS1 HIP1R RBM6 ABCB11 NOL9 EZH2 SMIM19

8.00e-041347559EFO_0005192
Diseasehearing impairment

ABHD5 EYA1 FOXC1

8.22e-0498553C1384666
Diseaseazoospermia (implicated_via_orthology)

CDC42BPG CDC42BPB

1.16e-0327552DOID:14227 (implicated_via_orthology)
Diseaseaspartate aminotransferase measurement

ANO4 LZTFL1 EDEM2 KIF16B ABCB11 HKDC1 EYA1

1.40e-03904557EFO_0004736
Diseasepack-years measurement, systolic blood pressure

RPS6KA2 SIPA1L2

1.84e-0334552EFO_0006335, EFO_0006526
DiseaseSpinocerebellar Ataxia Type 2

CACNA1A FOXC1

1.84e-0334552C0752121
DiseaseSpinocerebellar Ataxia Type 1

CACNA1A FOXC1

1.84e-0334552C0752120
DiseaseSpinocerebellar Ataxia Type 5

CACNA1A FOXC1

1.84e-0334552C0752123
DiseaseSpinocerebellar Ataxia Type 7

CACNA1A FOXC1

1.84e-0334552C0752125
DiseaseSpinocerebellar Ataxia Type 6 (disorder)

CACNA1A FOXC1

1.84e-0334552C0752124
DiseaseAtaxia, Spinocerebellar

CACNA1A FOXC1

1.84e-0334552C0087012

Protein segments in the cluster

PeptideGeneStartEntry
TFFHKKERRMRFYIR

CACNA1A

466

O00555
FTFLYVQMRKTLRFR

CCRL2

216

O00421
LRERQETARKMRKYY

CEP152

1301

O94986
FFIYMISFIFRKRRK

ABCA6

1111

Q8N139
AAARQIQKMRKFYFR

ABCB11

166

O95342
YKFMSRIDKQISRFR

ANO4

196

Q32M45
RMFLRFYSDNSVQRK

BMP1

836

P13497
SSYFRRKEKMFRFFI

CACNA1B

461

Q00975
ERVRRSERYQTMKLF

POLM

226

Q9NP87
RRRHRYKSRMNKTYC

HJURP

296

Q8NCD3
TVFRRYSRFREMHKT

KIF16B

1216

Q96L93
FRRFRKMNARQSKCY

RAG1

971

P15918
AISRPFRYKRKMTQR

DRD5

141

P21918
IFFAVKTRRKMDRYD

OCLN

261

Q16625
LFRTKSKRRFFFRVS

CDC42BPG

1401

Q6DT37
LYTKSKTKMRNRRFR

NOL9

456

Q5SY16
KTKMRNRRFRLAAFA

NOL9

461

Q5SY16
MFENGSFLRRRKRFK

FOXB2

96

Q5VYV0
NYMRFARSKRGLRLK

LZTFL1

16

Q9NQ48
FLSMLVSYRCRRNKR

GPR179

396

Q6PRD1
MFDNGSFLRRRKRFK

FOXD4L4

191

Q8WXT5
MFDNGSFLRRRKRFK

FOXD4L3

191

Q6VB84
RRRAMETLKLYFLFS

DDX60L

1386

Q5H9U9
LMREFYSLKRSRSKF

EDEM2

501

Q9BV94
SEYMRLRQLKRFRRA

EZH2

21

Q15910
MRKLAFRYRRVKEIY

EYA1

431

Q99502
QMLRTRSKRRFVFKV

CDC42BPB

1546

Q9Y5S2
MFENGSFLRRRKRFK

FOXB1

96

Q99853
RNFFRRASDMLYFKR

HIP1R

261

O75146
NGLYEFFRAKMRARR

CHERP

711

Q8IWX8
MFENGSFLRRRRRFK

FOXC1

161

Q12948
EKKMFRIRNRSYIDR

DHX36

151

Q9H2U1
AMRFVTRNVFKRTYA

COL6A5

1846

A8TX70
TYRDAVRRVMFARYK

RBM6

1106

P78332
FMKTLNYTARFSRFK

POLR2D

61

O15514
RSGRRSVRMYNKIFA

HKDC1

546

Q2TB90
NRSFRGQYKRMCRSK

SAMD9L

1456

Q8IVG5
MFDNGSFLRRRKRFK

FOXD4L5

191

Q5VV16
MFDNGSFLRRRKRFK

FOXD4L6

191

Q3SYB3
FSRYLSQMRNLRKLF

PRAMEF22

226

A3QJZ6
RAKMEDTLKRRFFYD

GARS1

121

P41250
DFMRLRRLSTKYRTE

PTPN12

31

Q05209
LFKQMDSRRYDVKTR

SMARCAL1

356

Q9NZC9
KFRAMATRTRQEYLK

SIPA1L2

796

Q9P2F8
LRYMKNRFLRSKTLD

ST6GALNAC1

496

Q9NSC7
QRLRPDFKRKYSSMF

ABHD5

226

Q8WTS1
SAMQRKLEDFRDYRR

ACTN3

321

Q08043
MSRLEKAYEARRFTR

RECQL

201

P46063
RYKYLRRLFRFRQMD

UNC50

31

Q53HI1
SRRSIFRMNGDKFRK

TUSC3

61

Q13454
TRYFRRRLKEMGFII

SPTLC2

446

O15270
MRSRSEKDYRLHKRF

STOX2

26

Q9P2F5
RARLKRKTQSFYMSS

SPIRE1

726

Q08AE8
SFGLFMYAKRNKRRI

SMIM19

36

Q96E16
SRDEFIFYSKRLMRL

UCKL1

346

Q9NWZ5
FMVLNRKRTIYRFSA

SCN11A

91

Q9UI33
MAYRARSKSRDRFFQ

ZC3HAV1

241

Q7Z2W4
FETYLRRAMKRFNKG

XPC

186

Q01831
KRYRDFSLRMEKYRT

TRIO

1226

O75962
KKFAVRRFFSVYLRR

RPS6KA2

6

Q15349
RRFFSVYLRRKSRSK

RPS6KA2

11

Q15349
RLFKMRQRRSDKYTF

MYOZ2

56

Q9NPC6