Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionkainate selective glutamate receptor activity

GRIK1 GRIK2 GRIK3

5.49e-086293GO:0015277
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIK1 GRIK2 GRIK3

1.85e-0617293GO:0004970
GeneOntologyMolecularFunctionligand-gated sodium channel activity

GRIK1 GRIK2 GRIK3

2.21e-0618293GO:0015280
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIK1 GRIK2 GRIK3

5.46e-0624293GO:0099507
GeneOntologyMolecularFunctiongated channel activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

7.19e-06334296GO:0022836
GeneOntologyMolecularFunctionglutamate receptor activity

GRIK1 GRIK2 GRIK3

7.87e-0627293GO:0008066
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

8.37e-06343296GO:0005261
GeneOntologyMolecularFunctionN-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

CHSY1 CHSY3

1.22e-054292GO:0050510
GeneOntologyMolecularFunctiontranscription corepressor activity

TLE5 TLE1 TLE2 TLE3 TLE4

1.80e-05229295GO:0003714
GeneOntologyMolecularFunctionglucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

CHSY1 CHSY3

3.04e-056292GO:0047238
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A CACNA1E GRIK1 ITPR3

3.48e-05129294GO:0005262
GeneOntologyMolecularFunctionextracellularly glutamate-gated ion channel activity

GRIK1 GRIK2

4.26e-057292GO:0005234
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

4.33e-05459296GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

4.65e-05465296GO:0046873
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

GRIK1 GRIK2 GRIK3 ITPR3

4.80e-05140294GO:0099094
GeneOntologyMolecularFunctionsodium channel activity

GRIK1 GRIK2 GRIK3

5.80e-0552293GO:0005272
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1A CACNA1E GRIK1 ITPR3

6.44e-05151294GO:0015085
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1E

7.29e-059292GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1E

7.29e-059292GO:0099626
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GRIK1 GRIK2 GRIK3

7.64e-0557293GO:1904315
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GRIK1 GRIK2 GRIK3

8.91e-0560293GO:0099529
GeneOntologyMolecularFunctionchannel activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

9.11e-05525296GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

9.21e-05526296GO:0022803
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GRIK1 GRIK2 GRIK3

1.13e-0465293GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GRIK1 GRIK2 GRIK3

1.13e-0465293GO:0022824
GeneOntologyMolecularFunctiontranscription coregulator activity

MED23 TLE5 TLE1 TLE2 TLE3 TLE4

1.32e-04562296GO:0003712
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GRIK1 GRIK2 GRIK3 ITPR3

1.66e-04193294GO:0015276
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GRIK1 GRIK2 GRIK3

1.73e-0475293GO:0098960
GeneOntologyMolecularFunctionligand-gated channel activity

GRIK1 GRIK2 GRIK3 ITPR3

1.80e-04197294GO:0022834
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1E

1.83e-0414292GO:0008331
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GRIK1 GRIK2 GRIK3

1.87e-0477293GO:0005230
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

2.40e-04627296GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

3.26e-04664296GO:0008324
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GRIK1 GRIK2 GRIK3

4.05e-04100293GO:0030594
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

GRIK1 GRIK2 GRIK3

4.67e-04105293GO:0015171
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

6.59e-04758296GO:0015318
GeneOntologyMolecularFunctionpotassium channel activity

GRIK1 GRIK2 GRIK3

8.32e-04128293GO:0005267
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

8.35e-04793296GO:0015075
GeneOntologyMolecularFunctionligand-gated calcium channel activity

GRIK1 ITPR3

9.23e-0431292GO:0099604
GeneOntologyMolecularFunctionSNARE binding

CACNA1A GRIK1 GRIK2

9.92e-04136293GO:0000149
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

DDX20 MED23 TLE5 TLE1 TLE2 TLE3 TLE4

1.11e-031160297GO:0030674
GeneOntologyMolecularFunctionglucuronosyltransferase activity

CHSY1 CHSY3

1.18e-0335292GO:0015020
GeneOntologyMolecularFunctionacetylgalactosaminyltransferase activity

CHSY1 CHSY3

1.18e-0335292GO:0008376
GeneOntologyMolecularFunctionexcitatory extracellular ligand-gated monoatomic ion channel activity

GRIK1 GRIK2

1.77e-0343292GO:0005231
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

GRIK1 GRIK2 GRIK3

1.79e-03167293GO:0015079
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

GRIK1 GRIK2 GRIK3

1.91e-03171293GO:0015081
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1A CACNA1E

2.03e-0346292GO:0005245
GeneOntologyMolecularFunctionmolecular adaptor activity

DDX20 MED23 TLE5 TLE1 TLE2 TLE3 TLE4

2.72e-031356297GO:0060090
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

GRIK1 GRIK2 GRIK3

3.29e-03207293GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

GRIK1 GRIK2 GRIK3

3.33e-03208293GO:0005342
GeneOntologyMolecularFunctionhexosyltransferase activity

CHSY1 CHSY3 STT3B

3.47e-03211293GO:0016758
GeneOntologyMolecularFunctiontransmembrane transporter activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

6.18e-031180296GO:0022857
GeneOntologyMolecularFunctionscaffold protein binding

GRIK1 GRIK2

8.03e-0393292GO:0097110
GeneOntologyMolecularFunctionglycosyltransferase activity

CHSY1 CHSY3 STT3B

8.22e-03288293GO:0016757
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

GRIK1 GRIK2 GRIK3

8.62e-03293293GO:0008514
GeneOntologyMolecularFunctiontransporter activity

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

9.41e-031289296GO:0005215
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1A CACNA1E

2.04e-02152292GO:0022843
GeneOntologyMolecularFunctionUDP-glycosyltransferase activity

CHSY1 CHSY3

2.07e-02153292GO:0008194
GeneOntologyBiologicalProcessnegative regulation of synaptic transmission, glutamatergic

GRIK1 GRIK2 GRIK3

6.35e-0713283GO:0051967
GeneOntologyBiologicalProcessnegative regulation of canonical Wnt signaling pathway

TLE5 TLE1 TLE2 TLE3 TLE4

1.86e-06154285GO:0090090
GeneOntologyBiologicalProcessnegative regulation of Wnt signaling pathway

TLE5 TLE1 TLE2 TLE3 TLE4

5.91e-06195285GO:0030178
GeneOntologyBiologicalProcessionotropic glutamate receptor signaling pathway

GRIK1 GRIK2 GRIK3

6.41e-0627283GO:0035235
GeneOntologyBiologicalProcessbehavioral response to pain

CACNA1A CACNA1E GRIK1

1.08e-0532283GO:0048266
GeneOntologyBiologicalProcessligand-gated ion channel signaling pathway

GRIK1 GRIK2 GRIK3

2.14e-0540283GO:1990806
GeneOntologyBiologicalProcessmulticellular organismal response to stress

CACNA1A CACNA1E GRIK1 GRIK2

2.43e-05126284GO:0033555
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

CACNA1A GRIK1 GRIK2 GRIK3

2.91e-05132284GO:0035249
GeneOntologyBiologicalProcessregulation of canonical Wnt signaling pathway

TLE5 TLE1 TLE2 TLE3 TLE4

3.68e-05285285GO:0060828
GeneOntologyBiologicalProcessresponse to pain

CACNA1A CACNA1E GRIK1

4.47e-0551283GO:0048265
GeneOntologyBiologicalProcessglutamate receptor signaling pathway

GRIK1 GRIK2 GRIK3

6.92e-0559283GO:0007215
GeneOntologyBiologicalProcesscanonical Wnt signaling pathway

TLE5 TLE1 TLE2 TLE3 TLE4

8.98e-05344285GO:0060070
GeneOntologyBiologicalProcessregulation of Wnt signaling pathway

TLE5 TLE1 TLE2 TLE3 TLE4

1.23e-04368285GO:0030111
GeneOntologyBiologicalProcessnegative regulation of synaptic transmission

GRIK1 GRIK2 GRIK3

1.72e-0480283GO:0050805
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

2.22e-04663286GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

2.24e-04664286GO:0099177
GeneOntologyBiologicalProcessregulation of synaptic transmission, glutamatergic

GRIK1 GRIK2 GRIK3

2.59e-0492283GO:0051966
GeneOntologyBiologicalProcessgamma-aminobutyric acid secretion

CACNA1A GRIK1

3.33e-0420282GO:0014051
GeneOntologyBiologicalProcesschondroitin sulfate biosynthetic process

CHSY1 CHSY3

3.33e-0420282GO:0030206
GeneOntologyBiologicalProcessregulation of short-term neuronal synaptic plasticity

GRIK1 GRIK2

4.04e-0422282GO:0048172
GeneOntologyBiologicalProcesstransmission of nerve impulse

CACNA1A CACNA1E GRIK2

4.62e-04112283GO:0019226
GeneOntologyBiologicalProcessregulation of anoikis

TLE5 TLE1

5.66e-0426282GO:2000209
GeneOntologyBiologicalProcesschondroitin sulfate proteoglycan biosynthetic process

CHSY1 CHSY3

5.66e-0426282GO:0050650
GeneOntologyBiologicalProcessWnt signaling pathway

TLE5 TLE1 TLE2 TLE3 TLE4

5.87e-04516285GO:0016055
GeneOntologyBiologicalProcessinhibitory postsynaptic potential

GRIK1 GRIK2

6.11e-0427282GO:0060080
GeneOntologyBiologicalProcessgamma-aminobutyric acid transport

CACNA1A GRIK1

6.57e-0428282GO:0015812
GeneOntologyBiologicalProcesschondroitin sulfate metabolic process

CHSY1 CHSY3

7.05e-0429282GO:0030204
GeneOntologyBiologicalProcessregulation of presynaptic membrane potential

GRIK2 GRIK3

8.60e-0432282GO:0099505
GeneOntologyBiologicalProcesschondroitin sulfate proteoglycan metabolic process

CHSY1 CHSY3

1.03e-0335282GO:0050654
GeneOntologyBiologicalProcessanoikis

TLE5 TLE1

1.15e-0337282GO:0043276
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

1.33e-03931286GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

1.33e-03931286GO:0007268
GeneOntologyBiologicalProcessregulation of long-term neuronal synaptic plasticity

GRIK1 GRIK2

1.34e-0340282GO:0048169
GeneOntologyBiologicalProcesstrans-synaptic signaling

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

1.39e-03939286GO:0099537
GeneOntologyBiologicalProcesssulfur compound metabolic process

CACNA1A CHSY1 CHSY3 ELOVL6

1.41e-03365284GO:0006790
GeneOntologyBiologicalProcesssynaptic signaling

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

1.70e-03976286GO:0099536
GeneOntologyBiologicalProcesssulfur compound biosynthetic process

CHSY1 CHSY3 ELOVL6

1.77e-03178283GO:0044272
GeneOntologyBiologicalProcessregulation of postsynaptic membrane potential

GRIK1 GRIK2 GRIK3

1.82e-03180283GO:0060078
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

CACNA1A CACNA1E

1.93e-0348282GO:0098703
GeneOntologyBiologicalProcesscalcium ion import into cytosol

CACNA1A CACNA1E

1.93e-0348282GO:1902656
GeneOntologyCellularComponentkainate selective glutamate receptor complex

GRIK1 GRIK2 GRIK3

4.29e-086283GO:0032983
GeneOntologyCellularComponentbeta-catenin-TCF complex

TLE1 TLE3 TLE4

6.10e-0713283GO:1990907
GeneOntologyCellularComponentsodium channel complex

GRIK1 GRIK2 GRIK3

7.68e-0629283GO:0034706
GeneOntologyCellularComponentcation channel complex

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

1.37e-05235285GO:0034703
GeneOntologyCellularComponentionotropic glutamate receptor complex

GRIK1 GRIK2 GRIK3

2.94e-0545283GO:0008328
GeneOntologyCellularComponentpresynaptic membrane

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

3.02e-05277285GO:0042734
GeneOntologyCellularComponentneurotransmitter receptor complex

GRIK1 GRIK2 GRIK3

4.04e-0550283GO:0098878
GeneOntologyCellularComponenttranscription regulator complex

DDX20 MED23 TLE1 TLE2 TLE3 TLE4

1.16e-04596286GO:0005667
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

1.31e-04378285GO:0034702
GeneOntologyCellularComponentpostsynaptic membrane

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

1.81e-04405285GO:0045211
GeneOntologyCellularComponentperikaryon

CACNA1A CACNA1E GRIK2 GRIK3

2.11e-04223284GO:0043204
GeneOntologyCellularComponentterminal bouton

GRIK1 GRIK2 GRIK3

2.83e-0496283GO:0043195
GeneOntologyCellularComponentpotassium channel complex

GRIK1 GRIK2 GRIK3

3.58e-04104283GO:0034705
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

MED23 TLE1 TLE3 TLE4

4.49e-04272284GO:0090575
GeneOntologyCellularComponenttransmembrane transporter complex

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

5.87e-04523285GO:1902495
GeneOntologyCellularComponentneuronal cell body

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

7.07e-04835286GO:0043025
GeneOntologyCellularComponenttransporter complex

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

7.37e-04550285GO:1990351
GeneOntologyCellularComponentdendrite

CACNA1A GRIK1 GRIK2 GRIK3 PREX1 ITPR3

8.15e-04858286GO:0030425
GeneOntologyCellularComponentdendritic tree

CACNA1A GRIK1 GRIK2 GRIK3 PREX1 ITPR3

8.25e-04860286GO:0097447
GeneOntologyCellularComponentsomatodendritic compartment

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 PREX1 ITPR3

9.44e-041228287GO:0036477
GeneOntologyCellularComponentsynaptic membrane

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

9.58e-04583285GO:0097060
GeneOntologyCellularComponentpresynapse

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

9.64e-04886286GO:0098793
GeneOntologyCellularComponentpostsynaptic density membrane

GRIK1 GRIK2 GRIK3

1.19e-03157283GO:0098839
GeneOntologyCellularComponentcell body

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

1.23e-03929286GO:0044297
GeneOntologyCellularComponentdendrite cytoplasm

GRIK2 GRIK3

1.24e-0339282GO:0032839
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1A CACNA1E

1.73e-0346282GO:0005891
GeneOntologyCellularComponentpostsynapse

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 CPSF2

1.97e-031018286GO:0098794
GeneOntologyCellularComponentpostsynaptic specialization membrane

GRIK1 GRIK2 GRIK3

2.40e-03201283GO:0099634
GeneOntologyCellularComponentdistal axon

GRIK1 GRIK2 GRIK3 PREX1

2.55e-03435284GO:0150034
GeneOntologyCellularComponentaxon terminus

GRIK1 GRIK2 GRIK3

2.72e-03210283GO:0043679
GeneOntologyCellularComponentmembrane protein complex

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ELOVL6 STT3B

2.97e-031498287GO:0098796
GeneOntologyCellularComponentplasma membrane protein complex

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

3.53e-03785285GO:0098797
GeneOntologyCellularComponentneuron projection terminus

GRIK1 GRIK2 GRIK3

3.65e-03233283GO:0044306
GeneOntologyCellularComponentglutamatergic synapse

CACNA1A GRIK1 GRIK2 GRIK3 CPSF2

4.19e-03817285GO:0098978
GeneOntologyCellularComponentcalcium channel complex

CACNA1A CACNA1E

4.29e-0373282GO:0034704
GeneOntologyCellularComponentGolgi cisterna membrane

CHSY1 CHSY3

7.01e-0394282GO:0032580
GeneOntologyCellularComponentreceptor complex

GRIK1 GRIK2 GRIK3 ITPR3

7.12e-03581284GO:0043235
GeneOntologyCellularComponentnuclear protein-containing complex

DDX20 CPSF2 MED23 TLE1 TLE3 TLE4

8.68e-031377286GO:0140513
GeneOntologyCellularComponentneuron projection cytoplasm

GRIK2 GRIK3

9.49e-03110282GO:0120111
GeneOntologyCellularComponentplasma membrane signaling receptor complex

GRIK1 GRIK2 GRIK3

1.12e-02350283GO:0098802
GeneOntologyCellularComponentendoplasmic reticulum protein-containing complex

ELOVL6 STT3B

1.21e-02125282GO:0140534
GeneOntologyCellularComponentGolgi cisterna

CHSY1 CHSY3

1.40e-02135282GO:0031985
DomainGroucho/TLE_N

TLE5 TLE1 TLE2 TLE3 TLE4

6.27e-155295IPR005617
DomainTLE_N

TLE5 TLE1 TLE2 TLE3 TLE4

6.27e-155295PF03920
DomainGroucho_enhance

TLE1 TLE2 TLE3 TLE4

2.34e-115294IPR009146
DomainPrefoldin

TLE5 TLE1 TLE2 TLE3 TLE4

8.17e-0872295IPR009053
DomainPBPe

GRIK1 GRIK2 GRIK3

2.70e-0618293SM00079
DomainIono_rcpt_met

GRIK1 GRIK2 GRIK3

2.70e-0618293IPR001508
DomainGlu/Gly-bd

GRIK1 GRIK2 GRIK3

2.70e-0618293IPR019594
DomainIontro_rcpt

GRIK1 GRIK2 GRIK3

2.70e-0618293IPR001320
DomainLig_chan

GRIK1 GRIK2 GRIK3

2.70e-0618293PF00060
DomainLig_chan-Glu_bd

GRIK1 GRIK2 GRIK3

2.70e-0618293SM00918
DomainLig_chan-Glu_bd

GRIK1 GRIK2 GRIK3

2.70e-0618293PF10613
DomainANF_receptor

GRIK1 GRIK2 GRIK3

2.52e-0537293PF01094
DomainANF_lig-bd_rcpt

GRIK1 GRIK2 GRIK3

2.52e-0537293IPR001828
DomainPeripla_BP_I

GRIK1 GRIK2 GRIK3

2.96e-0539293IPR028082
DomainCa_chan_IQ

CACNA1A CACNA1E

4.87e-057292PF08763
DomainGPHH

CACNA1A CACNA1E

4.87e-057292PF16905
DomainGPHH_dom

CACNA1A CACNA1E

4.87e-057292IPR031649
DomainVDCC_a1su_IQ

CACNA1A CACNA1E

4.87e-057292IPR014873
DomainCa_chan_IQ

CACNA1A CACNA1E

4.87e-057292SM01062
DomainChond_GalNAc

CHSY1 CHSY3

6.48e-058292IPR008428
DomainCHGN

CHSY1 CHSY3

6.48e-058292PF05679
DomainVDCCAlpha1

CACNA1A CACNA1E

1.04e-0410292IPR002077
DomainWD40_repeat_CS

TLE1 TLE2 TLE3 TLE4

1.15e-04164294IPR019775
DomainWD40

TLE1 TLE2 TLE3 TLE4

6.53e-04259294PF00400
DomainIon_trans_dom

CACNA1A CACNA1E ITPR3

7.21e-04114293IPR005821
DomainIon_trans

CACNA1A CACNA1E ITPR3

7.21e-04114293PF00520
DomainWD40

TLE1 TLE2 TLE3 TLE4

7.42e-04268294SM00320
DomainWD40_repeat

TLE1 TLE2 TLE3 TLE4

7.84e-04272294IPR001680
DomainWD_REPEATS_1

TLE1 TLE2 TLE3 TLE4

8.51e-04278294PS00678
DomainWD_REPEATS_2

TLE1 TLE2 TLE3 TLE4

8.62e-04279294PS50082
DomainWD_REPEATS_REGION

TLE1 TLE2 TLE3 TLE4

8.62e-04279294PS50294
DomainWD40_repeat_dom

TLE1 TLE2 TLE3 TLE4

1.09e-03297294IPR017986
Domain-

TLE1 TLE2 TLE3 TLE4

1.66e-033332942.130.10.10
DomainWD40/YVTN_repeat-like_dom

TLE1 TLE2 TLE3 TLE4

1.69e-03335294IPR015943
DomainChannel_four-helix_dom

CACNA1A CACNA1E

3.52e-0357292IPR027359
Domain-

CACNA1A CACNA1E

3.52e-03572921.20.120.350
Domain-

CHSY1 CHSY3

6.99e-03812923.90.550.10
DomainNucleotide-diphossugar_trans

CHSY1 CHSY3

8.20e-0388292IPR029044
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TLE5 TLE1 TLE2 TLE3 TLE4

3.45e-1114275M27402
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TLE1 TLE2 TLE3 TLE4

2.22e-0910274MM15156
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

TLE1 TLE2 TLE3 TLE4

1.55e-0726274MM14793
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

TLE1 TLE2 TLE3 TLE4

3.70e-0732274MM14975
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

TLE5 TLE1 TLE2 TLE3 TLE4

5.15e-0785275M27079
PathwayREACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS

GRIK1 GRIK2 GRIK3

7.45e-0710273M10272
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

TLE1 TLE2 TLE3 TLE4

1.14e-0642274M27272
PathwayREACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS

GRIK1 GRIK2 GRIK3

1.36e-0612273MM15142
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

TLE1 TLE2 TLE3 TLE4

1.96e-0648274M611
PathwayREACTOME_SIGNALING_BY_NOTCH1

TLE1 TLE2 TLE3 TLE4

1.12e-0574274M616
PathwayREACTOME_DEGRADATION_OF_BETA_CATENIN_BY_THE_DESTRUCTION_COMPLEX

TLE1 TLE2 TLE3 TLE4

1.45e-0579274MM14754
PathwayPID_BETA_CATENIN_NUC_PATHWAY

TLE5 TLE1 TLE2 TLE4

1.53e-0580274M223
PathwayREACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING

GRIK1 GRIK2 GRIK3

2.46e-0530273M18193
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

TLE1 TLE2 TLE3 TLE4

2.55e-0591274M27101
PathwayREACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING

GRIK1 GRIK2 GRIK3

2.99e-0532273MM15143
PathwayREACTOME_SIGNALING_BY_WNT

TLE5 TLE1 TLE2 TLE3 TLE4 ITPR3

3.07e-05330276M7847
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

4.42e-05211275MM14502
PathwayKEGG_MEDICUS_REFERENCE_CHONDROITIN_SULFATE_BIOSYNTHESIS

CHSY1 CHSY3

9.82e-058272M47920
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

1.42e-04270275M15514
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1A CACNA1E

1.92e-0411272M47958
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1E

1.92e-0411272MM14498
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1E

1.92e-0411272M26913
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1A CACNA1E ITPR3

2.09e-0461273MM15071
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

TLE1 TLE2 TLE3 TLE4

2.18e-04158274MM14791
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

CACNA1A CACNA1E ITPR3

3.42e-0472273MM14631
PathwayREACTOME_NEURONAL_SYSTEM

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

3.86e-04335275MM14503
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1A CACNA1E ITPR3

4.33e-0478273M1921
PathwayREACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS

CHSY1 CHSY3

5.92e-0419272MM14800
PathwayWNT_SIGNALING

TLE5 TLE1 TLE2

6.38e-0489273M5493
PathwayREACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS

CHSY1 CHSY3

6.57e-0420272M658
PathwayKEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE

CHSY1 CHSY3

7.97e-0422272M19166
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1A CACNA1E

8.72e-0423272M47666
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

TLE1 TLE2 TLE3 TLE4

9.47e-04233274M27099
PathwayREACTOME_NEURONAL_SYSTEM

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

9.77e-04411275M735
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1A CACNA1E

1.03e-0325272M47948
PathwayREACTOME_SIGNALING_BY_WNT

TLE1 TLE2 TLE3 TLE4

1.04e-03239274MM14756
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

CACNA1A CACNA1E ITPR3

1.12e-03108273M17034
PathwayREACTOME_SIGNALING_BY_NOTCH

TLE1 TLE2 TLE3 TLE4

1.16e-03246274M10189
PathwayKEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION

GRIK1 GRIK2 GRIK3 AVPR2

1.68e-03272274M13380
PathwaySIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES

PREX1 ITPR3

2.14e-0336272M1315
PathwayWP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING

GRIK1 GRIK2 GRIK3

2.35e-03140273M42572
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

GRIK1 GRIK2 GRIK3

2.55e-03144273MM14501
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A CACNA1E ITPR3

2.70e-03147273MM15854
PathwayWP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS

CHSY1 CHSY3

2.77e-0341272M48095
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CACNA1A CACNA1E ITPR3

2.92e-03151273M39329
PathwayPID_PS1_PATHWAY

TLE5 TLE1

3.47e-0346272M70
PathwayKEGG_TYPE_II_DIABETES_MELLITUS

CACNA1A CACNA1E

3.62e-0347272M19708
PathwayREACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM

CHSY1 CHSY3

3.77e-0348272MM14696
PathwayREACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM

CHSY1 CHSY3

4.09e-0350272M678
PathwayKEGG_TASTE_TRANSDUCTION

CACNA1A ITPR3

4.42e-0352272M5785
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

CACNA1A CACNA1E ITPR3

4.63e-03178273M2890
Pubmed

Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.

TLE5 TLE1 TLE2 TLE3 TLE4

2.80e-1652958365415
Pubmed

Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.

TLE5 TLE1 TLE2 TLE3 TLE4

1.68e-1562958573724
Pubmed

A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.

TLE5 TLE1 TLE2 TLE3 TLE4

5.88e-15729524024827
Pubmed

The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.

TLE5 TLE1 TLE2 TLE3 TLE4

1.57e-14829516002402
Pubmed

All Tcf HMG box transcription factors interact with Groucho-related co-repressors.

TLE5 TLE1 TLE2 TLE3 TLE4

2.21e-131229511266540
Pubmed

Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube.

TLE5 TLE1 TLE3 TLE4

3.90e-13429411290324
Pubmed

TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination.

TLE1 TLE2 TLE3 TLE4

3.90e-1342948645603
Pubmed

Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.

TLE1 TLE2 TLE3 TLE4

1.95e-1252941303260
Pubmed

Grg3, a murine Groucho-related gene, is expressed in the developing nervous system and in mesenchyme-induced epithelial structures.

TLE5 TLE1 TLE3 TLE4

1.95e-1252948989517
Pubmed

Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development.

TLE5 TLE1 TLE3 TLE4

5.84e-1262948892234
Pubmed

Expression of Groucho/TLE proteins during pancreas development.

TLE5 TLE1 TLE2 TLE3 TLE4

1.18e-112429518778483
Pubmed

A comparison of Notch, Hes and Grg expression during murine embryonic and post-natal development.

TLE5 TLE1 TLE3 TLE4

2.72e-11829410512199
Pubmed

Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.

TLE1 TLE2 TLE3 TLE4

2.72e-11829420735826
Pubmed

Spatial distribution of the full-length members of the Grg family during embryonic neurogenesis reveals a "Grg-mediated repression map" in the mouse telencephalon.

TLE1 TLE2 TLE3 TLE4

8.15e-111029430571765
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

TLE1 TLE2 TLE3 TLE4

1.28e-101129415499562
Pubmed

Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex.

TLE1 TLE2 TLE3 TLE4

2.77e-101329422735158
Pubmed

Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.

TLE1 TLE2 TLE3 TLE4

3.88e-101429417202186
Pubmed

Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.

TLE1 TLE2 TLE3

5.21e-1032938808280
Pubmed

The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain.

GRIK1 GRIK2 GRIK3

5.21e-10329331513786
Pubmed

Differential trafficking of GluR7 kainate receptor subunit splice variants.

GRIK1 GRIK2 GRIK3

5.21e-10329315805114
Pubmed

Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity.

TLE1 TLE3 TLE4

5.21e-10329330045946
Pubmed

Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice.

GRIK1 GRIK2 GRIK3

5.21e-1032939880586
Pubmed

Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway.

TLE1 TLE2 TLE3 TLE4

5.29e-10152949291577
Pubmed

Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.

TLE1 TLE2 TLE3 TLE4

1.18e-091829433658226
Pubmed

Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.

TLE1 TLE2 TLE3 TLE4

1.18e-091829411731482
Pubmed

Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool.

GRIK1 GRIK2 GRIK3

2.08e-09429315513934
Pubmed

Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.

GRIK1 GRIK2 GRIK3

2.08e-09429330241548
Pubmed

PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins.

TLE5 TLE1 TLE2

2.08e-0942939887105
Pubmed

Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses.

GRIK1 GRIK2 GRIK3

2.08e-09429319369569
Pubmed

Developmental expression patterns of kainate receptors in the mouse spinal cord.

GRIK1 GRIK2 GRIK3

5.21e-09529323076118
Pubmed

Kainate receptors: pharmacology, function and therapeutic potential.

GRIK1 GRIK2 GRIK3

5.21e-09529318793656
Pubmed

Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.

GRIK1 GRIK2 GRIK3

5.21e-09529328228252
Pubmed

Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.

GRIK1 GRIK2 GRIK3

5.21e-09529312223554
Pubmed

Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.

TLE5 TLE1 TLE3

5.21e-09529310748198
Pubmed

Molecular determinants of kainate receptor trafficking.

GRIK1 GRIK2 GRIK3

5.21e-09529318358623
Pubmed

Development of laminar distributions of kainate receptors in the somatosensory cortex of mice.

GRIK1 GRIK2 GRIK3

5.21e-0952939593973
Pubmed

Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains.

GRIK1 GRIK2 GRIK3

5.21e-09529329058671
Pubmed

N-glycan content modulates kainate receptor functional properties.

GRIK1 GRIK2 GRIK3

1.04e-08629328714086
Pubmed

Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.

GRIK1 GRIK2 GRIK3

1.82e-08729317428973
Pubmed

Glutamate receptors in cortical plasticity: molecular and cellular biology.

GRIK1 GRIK2 GRIK3

1.82e-0872939016303
Pubmed

Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.

GRIK1 GRIK2 GRIK3

1.82e-08729319342380
Pubmed

Glutamate receptors: brain function and signal transduction.

GRIK1 GRIK2 GRIK3

1.82e-0872939651535
Pubmed

Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate.

GRIK1 GRIK2 GRIK3

1.82e-0872931310861
Pubmed

Six3 and Six6 activity is modulated by members of the groucho family.

TLE5 TLE1 TLE3

2.91e-08829312441302
Pubmed

Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.

TLE1 TLE3 TLE4

2.91e-08829328296634
Pubmed

Transmembrane topology of the glutamate receptor subunit GluR6.

GRIK1 GRIK2 GRIK3

2.91e-0882938163463
Pubmed

Expression of glutamate receptor subunit genes during development of the mouse retina.

GRIK1 GRIK2 GRIK3

4.36e-0892939051806
Pubmed

Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.

GRIK1 GRIK2 GRIK3

1.48e-071329320859245
Pubmed

The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation.

TLE5 TLE1 TLE3

4.22e-071829322434868
Pubmed

TCF and Groucho-related genes influence pituitary growth and development.

TLE5 TLE3 TLE4

4.22e-071829312907761
Pubmed

Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering.

MED23 TLE1 TLE4

5.01e-07192939070936
Pubmed

Transcriptional regulation of cortical neuron migration by POU domain factors.

TLE1 TLE3 TLE4

5.89e-072029311859196
Pubmed

Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation.

GRIK1 GRIK2

6.71e-07229212947409
Pubmed

Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.

GRIK1 GRIK2

6.71e-07229215537878
Pubmed

Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.

GRIK1 GRIK2

6.71e-07229215673679
Pubmed

Subunit composition of kainate receptors in hippocampal interneurons.

GRIK1 GRIK2

6.71e-07229211144357
Pubmed

Groucho/TLE family proteins and transcriptional repression.

TLE1 TLE3

6.71e-07229210831834
Pubmed

Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence.

GRIK1 GRIK3

6.71e-07229219320626
Pubmed

Grg1 acts as a lung-specific oncogene in a transgenic mouse model.

TLE5 TLE1

6.71e-07229216452182
Pubmed

Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy.

GRIK1 GRIK2

6.71e-07229225043179
Pubmed

Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.

GRIK2 GRIK3

6.71e-07229215094479
Pubmed

Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus.

GRIK1 GRIK2

6.71e-07229211182092
Pubmed

Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.

GRIK1 GRIK2

6.71e-07229215928066
Pubmed

Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.

CACNA1A CACNA1E

6.71e-07229216381801
Pubmed

Chondroitin sulfate synthase-3. Molecular cloning and characterization.

CHSY1 CHSY3

6.71e-07229212907687
Pubmed

Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors.

GRIK1 GRIK2

6.71e-07229215358807
Pubmed

Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit.

GRIK1 GRIK2

6.71e-07229214724198
Pubmed

GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.

GRIK2 GRIK3

6.71e-07229217620617
Pubmed

Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences.

GRIK1 GRIK2

6.71e-0722928700852
Pubmed

The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones.

GRIK1 GRIK2

6.71e-07229215539395
Pubmed

Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression.

TLE3 TLE4

6.71e-07229225446531
Pubmed

Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.

TLE1 TLE3

6.71e-07229233571907
Pubmed

Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.

GRIK1 GRIK2

6.71e-07229224760837
Pubmed

TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk maintains intestinal immune homeostasis.

TLE3 TLE4

6.71e-07229236801171
Pubmed

A mosaic of functional kainate receptors in hippocampal interneurons.

GRIK1 GRIK2

6.71e-07229215483117
Pubmed

Functional characterization of kainate receptors in the mouse nucleus accumbens.

GRIK1 GRIK2

6.71e-07229211985817
Pubmed

RNA editing of human kainate receptor subunits.

GRIK1 GRIK2

6.71e-0722927696618
Pubmed

Atypical functional properties of GluK3-containing kainate receptors.

GRIK2 GRIK3

6.71e-07229220007474
Pubmed

Q/R site editing controls kainate receptor inhibition by membrane fatty acids.

GRIK1 GRIK2

6.71e-07229216221857
Pubmed

Altered long-term synaptic plasticity and kainate-induced Ca2+ transients in the substantia gelatinosa neurons in GLU(K6)-deficient mice.

GRIK1 GRIK2

6.71e-07229216219388
Pubmed

Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6.

GRIK1 GRIK2

6.71e-0722928260617
Pubmed

Combinatorial expression patterns of individual TLE proteins during cell determination and differentiation suggest non-redundant functions for mammalian homologs of Drosophila Groucho.

TLE1 TLE4

6.71e-0722929572356
Pubmed

Subunit composition and alternative splicing regulate membrane delivery of kainate receptors.

GRIK1 GRIK2

6.71e-07229215014126
Pubmed

Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus.

GRIK1 GRIK2

6.71e-07229211069933
Pubmed

Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.

GRIK1 GRIK2 GRIK3

9.13e-07232938464923
Pubmed

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

GRIK1 GRIK2 GRIK3

1.04e-062429335746896
Pubmed

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

CACNA1A GRIK1 GRIK2

1.04e-062429322534482
Pubmed

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

TLE1 TLE2 TLE3

1.68e-062829317041588
Pubmed

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

CACNA1A CACNA1E

2.01e-06329238996073
Pubmed

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression.

TLE5 TLE2

2.01e-06329219460168
Pubmed

Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription.

TLE5 TLE2

2.01e-06329210825294
Pubmed

Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.

TLE1 TLE4

2.01e-06329218258796
Pubmed

Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations.

GRIK1 GRIK2

2.01e-06329215509753
Pubmed

Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.

CHSY1 CHSY3

2.01e-06329233089528
Pubmed

TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells.

TLE5 TLE1

2.01e-06329222952044
Pubmed

The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain.

TLE5 TLE1

2.01e-06329212030375
Pubmed

Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.

GRIK2 GRIK3

2.01e-06329232567721
Pubmed

Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina.

GRIK1 GRIK3

2.01e-0632927538211
Pubmed

Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival.

TLE5 TLE1

2.01e-06329222354967
Pubmed

Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

CACNA1A CACNA1E

2.01e-06329224523520
InteractionRIPPLY2 interactions

TLE5 TLE1 TLE2 TLE3 TLE4

6.55e-1120295int:RIPPLY2
InteractionSIX6 interactions

TLE5 TLE1 TLE3 TLE4

1.13e-0911294int:SIX6
InteractionHLX interactions

TLE5 TLE1 TLE2 TLE3 TLE4

1.81e-0937295int:HLX
InteractionRIPPLY1 interactions

TLE5 TLE1 TLE2 TLE3 TLE4

1.42e-0855295int:RIPPLY1
InteractionSIX3 interactions

TLE5 TLE1 TLE3 TLE4

1.65e-0820294int:SIX3
InteractionMFAP4 interactions

TLE5 ARSK TLE1 TLE2 TLE3 TLE4

4.03e-08139296int:MFAP4
InteractionISX interactions

TLE5 TLE1 TLE3 TLE4

1.06e-0731294int:ISX
InteractionPRDM1 interactions

TLE5 TLE1 TLE2 TLE3 TLE4

1.22e-0784295int:PRDM1
InteractionGRIK4 interactions

GRIK1 GRIK2 GRIK3

1.49e-078293int:GRIK4
InteractionTLE4 interactions

TLE5 TLE1 TLE2 TLE3 TLE4

1.93e-0792295int:TLE4
InteractionMSX1 interactions

TLE5 TLE1 TLE2 TLE4

1.97e-0736294int:MSX1
InteractionGRIK3 interactions

GRIK1 GRIK2 GRIK3

3.19e-0710293int:GRIK3
InteractionVENTX interactions

TLE5 TLE1 TLE2 TLE3 TLE4

3.57e-07104295int:VENTX
InteractionEN1 interactions

TLE5 TLE1 TLE2 TLE3 TLE4

4.73e-07110295int:EN1
InteractionRIPPLY3 interactions

TLE5 TLE1 TLE2 TLE3 TLE4

5.17e-07112295int:RIPPLY3
InteractionSIX1 interactions

TLE5 TLE1 TLE3 STT3B

7.00e-0749294int:SIX1
InteractionTLE3 interactions

STAM MED23 TLE5 TLE1 TLE2 TLE3 TLE4

8.15e-07376297int:TLE3
InteractionHES6 interactions

TLE5 TLE1 TLE3 TLE4

8.92e-0752294int:HES6
InteractionPAX9 interactions

TLE5 TLE1 TLE2 TLE3 TLE4

1.08e-06130295int:PAX9
InteractionTLE2 interactions

TLE5 TLE1 TLE2 TLE3 TLE4

1.36e-06136295int:TLE2
InteractionVSX1 interactions

TLE5 TLE1 TLE3 TLE4

2.34e-0666294int:VSX1
InteractionGRIK5 interactions

GRIK1 GRIK2 GRIK3

3.00e-0620293int:GRIK5
InteractionTBX20 interactions

TLE1 TLE3 TLE4

3.50e-0621293int:TBX20
InteractionSMG7 interactions

TLE5 TLE1 TLE2 ABTB2 TLE3 TLE4

5.24e-06319296int:SMG7
InteractionGATA3 interactions

CPSF2 TLE5 TLE1 PEG10 TLE3

6.46e-06187295int:GATA3
InteractionGSC interactions

TLE5 TLE1 TLE3 TLE4

7.09e-0687294int:GSC
InteractionFOXL1 interactions

CPSF2 TLE5 TLE1 TLE3 TLE4

8.12e-06196295int:FOXL1
InteractionFOXI1 interactions

TLE5 TLE1 TLE3 TLE4

8.85e-0692294int:FOXI1
InteractionSIX2 interactions

TLE5 TLE1 TLE3

9.55e-0629293int:SIX2
InteractionTLE1 interactions

TLE5 TLE1 TLE2 TLE3 TLE4

1.22e-05213295int:TLE1
InteractionGRIK2 interactions

GRIK1 GRIK2 GRIK3

1.29e-0532293int:GRIK2
InteractionGRIK1 interactions

GRIK1 GRIK2 GRIK3

1.85e-0536293int:GRIK1
InteractionPAX8 interactions

TLE5 TLE1 TLE3 TLE4

1.86e-05111294int:PAX8
InteractionTBR1 interactions

TLE5 TLE1 TLE3 TLE4

2.00e-05113294int:TBR1
InteractionTBXT interactions

TLE5 TLE1 TLE3 TLE4

2.21e-05116294int:TBXT
InteractionSTARD7 interactions

TLE5 TLE1 TLE3

2.36e-0539293int:STARD7
InteractionPAX7 interactions

TLE5 TLE1 TLE3 TLE4

2.88e-05124294int:PAX7
InteractionBARHL1 interactions

TLE1 TLE2

4.18e-057292int:BARHL1
InteractionTLX2 interactions

TLE5 TLE1 TLE3 TLE4

4.89e-05142294int:TLX2
InteractionTLX3 interactions

TLE5 TLE1 TLE2 TLE3 TLE4

5.42e-05291295int:TLX3
InteractionFOXA3 interactions

TLE1 TLE2 TLE3

5.65e-0552293int:FOXA3
InteractionHHEX interactions

TLE5 TLE1 TLE3

6.32e-0554293int:HHEX
InteractionSP7 interactions

CPSF2 TLE5 TLE1 TLE3 TLE4

6.67e-05304295int:SP7
InteractionZNF503 interactions

MED23 TLE5 TLE3

7.44e-0557293int:ZNF503
InteractionGATA1 interactions

CPSF2 TLE5 TLE1 TLE3

1.01e-04171294int:GATA1
InteractionTLX1 interactions

TLE5 TLE1 TLE3 TLE4

1.10e-04175294int:TLX1
InteractionRBM14 interactions

DDX20 CPSF2 MED23 PEG10 TLE3 STT3B

1.15e-04553296int:RBM14
InteractionLCN6 interactions

CHSY1 CHSY3 ARSK

1.21e-0467293int:LCN6
InteractionDZIP3 interactions

NUF2 MED23 PEG10 TLE3

1.31e-04183294int:DZIP3
InteractionLEF1 interactions

TLE1 TLE2 TLE4

1.32e-0469293int:LEF1
InteractionGATA2 interactions

TLE5 TLE1 TLE3 TLE4

1.81e-04199294int:GATA2
InteractionFEV interactions

TLE5 TLE1 TLE3 TLE4

1.95e-04203294int:FEV
InteractionCABP1 interactions

CACNA1A ITPR3

2.08e-0415292int:CABP1
InteractionQPRT interactions

TLE1 TLE3 TLE4

2.36e-0484293int:QPRT
InteractionPAX2 interactions

TLE5 TLE1 TLE3

2.44e-0485293int:PAX2
InteractionIRF4 interactions

TLE5 TLE1 PEG10

2.44e-0485293int:IRF4
InteractionATP2A1 interactions

TAPT1 ABTB2 TLE3 STT3B ITPR3

3.12e-04423295int:ATP2A1
InteractionKALRN interactions

CACNA1A CHSY1 GRIK1

3.50e-0496293int:KALRN
InteractionTLE5 interactions

TLE5 TLE1 TLE2 TLE3 TLE4

3.85e-04443295int:TLE5
InteractionMYL11 interactions

ABTB2 TLE3

4.13e-0421292int:MYL11
InteractionCLOCK interactions

NUF2 TLE2 TLE3

4.18e-04102293int:CLOCK
InteractionUTY interactions

TLE1 TLE2

4.96e-0423292int:UTY
InteractionZFHX3 interactions

MED23 TLE5 TLE3

5.08e-04109293int:ZFHX3
InteractionMYCBPAP interactions

CHSY1 CHSY3

7.92e-0429292int:MYCBPAP
InteractionFOXB1 interactions

TLE1 TLE3 TLE4

9.46e-04135293int:FOXB1
InteractionPLAUR interactions

CHSY1 CHSY3 ARSK

9.46e-04135293int:PLAUR
InteractionGFI1B interactions

TLE5 TLE1 TLE3

9.66e-04136293int:GFI1B
InteractionFOXQ1 interactions

TLE5 TLE1 TLE3

1.07e-03141293int:FOXQ1
InteractionSOX15 interactions

TLE5 TLE1 TLE3

1.07e-03141293int:SOX15
InteractionNFIB interactions

TLE5 TLE1 TLE3

1.09e-03142293int:NFIB
InteractionRUNX1 interactions

TLE5 TLE1 TLE2 TLE3

1.13e-03324294int:RUNX1
InteractionMAD2L2 interactions

AVPR2 TLE2 PEG10 TLE3

1.15e-03325294int:MAD2L2
InteractionCHSY3 interactions

CHSY1 CHSY3

1.22e-0336292int:CHSY3
InteractionCPSF7 interactions

DDX20 MED23 TLE5 TLE3

1.33e-03338294int:CPSF7
InteractionNOTCH1 interactions

CACNA1A MED23 ABTB2 TLE3

1.43e-03345294int:NOTCH1
CytobandEnsembl 112 genes in cytogenetic band chr9q21

TLE1 TLE4

7.03e-03199292chr9q21
Cytoband19p13.3

TLE5 TLE2

9.83e-0323729219p13.3
CytobandEnsembl 112 genes in cytogenetic band chr19p13

CACNA1A TLE5 TLE2

1.36e-02797293chr19p13
GeneFamilyGlutamate ionotropic receptor kainate type subunits

GRIK1 GRIK2 GRIK3

1.56e-0852231199
GeneFamilyBeta 4-glycosyltransferases

CHSY1 CHSY3

1.90e-0417222425
GeneFamilyWD repeat domain containing

TLE1 TLE2 TLE3 TLE4

2.57e-04262224362
GeneFamilyBeta 3-glycosyltransferases

CHSY1 CHSY3

3.84e-0424222426
GeneFamilyCalcium voltage-gated channel subunits

CACNA1A CACNA1E

4.51e-0426222253
CoexpressionGSE26669_CD4_VS_CD8_TCELL_IN_MLR_COSTIM_BLOCK_DN

CHSY1 ELOVL6 TAPT1 PREX1 TLE4

2.46e-06199295M4673
CoexpressionGSE36078_WT_VS_IL1R_KO_LUNG_DC_DN

CHSY1 TRAPPC11 ARSK PREX1 AFG1L

2.52e-06200295M9290
CoexpressionGSE7509_DC_VS_MONOCYTE_WITH_FCGRIIB_STIM_DN

CACNA1A CHSY1 GRIK2 ABTB2

6.34e-05197294M6835
CoexpressionGSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_UP

CHSY1 ELOVL6 PREX1 TLE3

6.73e-05200294M10032
CoexpressionNAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN

TLE1 TLE2 PEG10

8.43e-0577293M17937
CoexpressionGRYDER_PAX3FOXO1_ENHANCERS_IN_TADS

CHSY1 NUF2 TLE5 PREX1 TLE1 PEG10 TLE3

9.10e-051009297M157
CoexpressionGRYDER_PAX3FOXO1_TOP_ENHANCERS

CHSY1 PREX1 TLE1 PEG10 TLE3

1.12e-04441295M172
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1A CACNA1E GRIK2 GRIK3

4.04e-06167294c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1A CACNA1E GRIK2 GRIK3

4.24e-06169294b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellSevere-B_naive-8|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TAPT1 TLE5 TLE1 PEG10

4.76e-06174294f3f8c924420f46321bd47e2b97f18c7241541599
ToppCellMild/Remission-B_naive-8|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TAPT1 TLE5 TLE1 PEG10

7.47e-061952940a3221e4d1fa31a35868bdda0f0cc873c233b407
ToppCellSevere-B_naive-4|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TAPT1 TLE5 TLE1 PEG10

7.77e-061972940905417e3fa7424575bc48e8054256d5799306d7
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-|Neuronal / cells hierarchy compared to all cells using T-Statistic

GRIK1 GRIK2 GRIK3 ABTB2

8.25e-06200294a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A|Neuronal / cells hierarchy compared to all cells using T-Statistic

GRIK1 GRIK2 GRIK3 ABTB2

8.25e-062002948d51b4f7b7002ee51401ebe5eaca1e8f04bfadd5
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A GRIK1 GRIK2 GRIK3

8.25e-062002944fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A GRIK1 GRIK2 GRIK3

8.25e-06200294f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A GRIK1 GRIK2 GRIK3

8.25e-06200294cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A-|Neuronal / cells hierarchy compared to all cells using T-Statistic

GRIK1 GRIK2 GRIK3 ABTB2

8.25e-062002946a44439e4a7ce3627271375b04cfcfb9467218f4
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

GRIK1 GRIK2 GRIK3 ABTB2

8.25e-0620029433b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6|Neuronal / cells hierarchy compared to all cells using T-Statistic

GRIK1 GRIK2 GRIK3 ABTB2

8.25e-062002949719fabddc34051949468a7520289e3c750de4f8
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A--L4-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

GRIK1 GRIK2 GRIK3 ABTB2

8.25e-06200294cb1f4b0d66da5b0466ff17b29e7034d451d93e4f
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A GRIK1 GRIK2 GRIK3

8.25e-06200294310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A GRIK1 GRIK2 GRIK3

8.25e-06200294c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A GRIK1 GRIK2 GRIK3

8.25e-06200294961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Krt73|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

CHSY3 GRIK1 GRIK2

8.34e-051312939ca209a8652aae603c4a867ea06b06ac51e7d189
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GRIK1 GRIK2 PEG10

1.30e-041522938ff5a178a8f3550d89a003c0858820aab3773386
ToppCellLeuk-UTI-Lymphocyte-T_NK-Treg|Leuk-UTI / Disease, Lineage and Cell Type

STAM TLE5 TLE2

1.32e-04153293b24c693b142206d13b29c96faa7f79a1a22bc2ef
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP3_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GRIK2 GRIK3 PREX1

1.77e-04169293d9c3b22f62b882b8a2ea6fd9cf7afbe6d1775745
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1A GRIK1 GRIK2

1.77e-0416929396a2aec9acf8a6f966973c035e5ade456cf47772
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TRAPPC11 AVPR2 TLE2

1.83e-041712936a2f88c2a62cb2f69797804e24eb1137a3e148de
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TRAPPC11 AVPR2 TLE2

1.83e-041712939be3554626408bb897d1f1c43b3ab4a92651f2e2
ToppCellMild/Remission-B_naive-8|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TAPT1 TLE5 TLE1

1.90e-04173293694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 PEG10

1.90e-041732930ba64e5385fe714f876002520f8b5202809bf11e
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A GRIK2 PEG10

1.93e-041742939f114e61458659005b6d0b4aa30a7a059e7aa5c6
ToppCell5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A GRIK2 PEG10

1.96e-04175293182e45f5c02214d6b9f317ff5dc43af8b42de978
ToppCellwk_15-18-Epithelial-PNS-COL20A1+_Schwann|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GRIK1 GRIK2 GRIK3

2.03e-04177293b8cc6a7abf83a9844a5293b6cc4b19135b51fd53
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_TH|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK3 PEG10

2.10e-04179293797d165718dd1d819e65add3a7859f87b32238a5
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1E GRIK1 AVPR2

2.10e-04179293ec1d7017da325647b629de703135a404bbdc627d
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHSY1 STAM ABTB2

2.10e-04179293d3438fed0d85d5ed5afa8ff820c45143d77b6c0d
ToppCell5'-Adult-LymphNode-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A NUF2 TLE2

2.13e-04180293cc974ac352ef2adc953fb5f325880e5857595889
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 PEG10

2.13e-04180293b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCellcritical-Lymphoid-NK|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CHSY3 GRIK3 PEG10

2.13e-041802935abf778395392244daaec876f306ed7e4f388686
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GRIK2 GRIK3 PREX1

2.17e-04181293fad7ba168f541ac9d04edebc206f191e48bb7e99
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-8|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TAPT1 TLE1 PEG10

2.17e-04181293ca34d83daca10c5fa52ecdf4eba7d31b4e7e056e
ToppCellRA-07._Pericyte|World / Chamber and Cluster_Paper

CACNA1A TLE1 TLE2

2.20e-041822932075efeae633550fb2eb026d0dfd741c8252482e
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1E CHSY3 ABTB2

2.20e-04182293d1c3cc2942faec7527a3c25869fd65c17899e5e4
ToppCell5'-Adult-LymphNode-Epithelial-epithelial_progenitor_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A NUF2 TLE2

2.20e-04182293cf0a6f99b825eb75f95f376c16a504e2669820ac
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GRIK2 GRIK3 PREX1

2.20e-04182293bfb725fff3d20066d8ac0a6ba2f88498fcbd876e
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GRIK2 GRIK3 PREX1

2.20e-04182293f7f9be9c7ef8da9864d6aefe20043b26e1bb8697
ToppCellPCW_05-06-Neuronal-Neuronal_SCP|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GRIK2 GRIK3 PREX1

2.20e-04182293b4fc5e4f5d8440a3c9ee0a6fd0da87b43cabc8c6
ToppCellInfluenza_Severe-B_naive|World / Disease group and Cell class

TAPT1 TLE1 PEG10

2.20e-04182293e4885a5e6065c9c403cb2d305228691d6ae4ecb6
ToppCell5'-Adult-LymphNode-Epithelial-epithelial_progenitor_cell-TA|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A NUF2 TLE2

2.20e-0418229349e4b362f88d235ed12aabcabb54787c16e32cb7
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1E CHSY3 ABTB2

2.20e-0418229392f83f29e358000cd86a709eb8b6199761ffe8bd
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft-Tuft_L.0.7.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1E CHSY3 ABTB2

2.20e-0418229302baca9a72c7b559c3e452693b3b134af804c868
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GRIK2 GRIK3 PREX1

2.24e-04183293f517215ff45dec914af52dfdbc4579c19654c3aa
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GRIK2 GRIK3 PREX1

2.31e-0418529356c7a0dbf141728ac76b8c90af197719942ca67c
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

GRIK2 GRIK3 PREX1

2.31e-04185293a8946379fc066903fe8f4bc9cbf693b7b424a0cd
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STAM AVPR2 ABTB2

2.35e-04186293aeac0c2db173cd1ea45b5052ab418d6cacd198d8
ToppCellControl-Lymphoid-ILC_A|World / Disease state, Lineage and Cell class

STAM ELOVL6 TLE1

2.35e-041862937bc939bf4e71bb4c6409b862c1f6c547d775e089
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 GRIK3

2.38e-0418729385f1678338a47d91e296f0620d4887f057eb7e70
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-8|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TAPT1 TLE1 PEG10

2.38e-04187293c10d6a774b3e83f64e47b9ad08f5d6b0dc60d163
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-ILC_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ELOVL6 TLE1 PEG10

2.38e-04187293f31d865ce2a21bdf64dbe29ee3e4505ab482604a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 TLE2

2.38e-04187293d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCellCOVID-19_Severe-B_memory|World / disease group, cell group and cell class

CACNA1E TLE1 PEG10

2.38e-04187293f29c71f2505bb64f3010ada491d422b87a6f7db3
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TLE5 TLE1 TLE4

2.42e-04188293f7dc29dfec68236883469e848be5db34f5526d6b
ToppCellnormal-na-Lymphocytic_B-B_naive-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

TAPT1 TLE1 PEG10

2.42e-04188293ec72ba73b10c6f2ff39699b6b46b90a3e95a4c24
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TLE5 TLE1 TLE4

2.42e-041882935ae8ccdd328cf117da1d01ced2c3b7f763a5f1f1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TAPT1 TLE1 PEG10

2.42e-04188293d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TLE5 TLE1 TLE4

2.42e-041882939abd78970bbe4ed03b59a83da63bbd334712f605
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TAPT1 TLE1 PEG10

2.46e-04189293e2bb5900d210386b7b74938e7a3636d0c7ba1bcf
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STAM AVPR2 ABTB2

2.46e-04189293bfc76a72b600d641c8fe58346e5d8986c34f3981
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 TLE2

2.46e-04189293f0aaf2994d319a39877d2845eaab9f166adead4e
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 TLE2

2.50e-0419029356cc761e50fddfb5366391518b4d8e16589b6b42
ToppCellwk_08-11-Epithelial-PNS-Schwann_precursor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

GRIK2 GRIK3 PREX1

2.50e-041902934a777d8aa19cadd3b61b023772df142421a89113
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GRIK2 STAM ABTB2

2.50e-04190293b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 TLE2

2.50e-0419029325d4b591f75c26e404a34c42f1742d580af6598d
ToppCellsevere-B_naive|World / disease stage, cell group and cell class

TAPT1 TLE1 PEG10

2.50e-041902938dfe067d75573289299a5fba42b6c9b26e5fb430
ToppCellsevere-B_naive|severe / disease stage, cell group and cell class

TAPT1 TLE1 PEG10

2.50e-041902932430a1fd18385305bf1b604747ff64026a8d5edf
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TAPT1 TLE1 PEG10

2.54e-04191293b374676ac90572d65895052d46469906e2b6fd93
ToppCellILEUM-inflamed-(1)_T_cell-(1)_Th17_Trm|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ELOVL6 TLE1 MAP3K4

2.58e-0419229312f7ea575da5d650c740e6060f5dab0478e563dd
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STAM ELOVL6 ABTB2

2.58e-041922932510f22197502f60fd266b7f42eff040f25b8ae7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STAM ELOVL6 ABTB2

2.58e-04192293e8e316f396834bcd34843e56e1d86f310fd6aada
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 GRIK3

2.58e-04192293dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCell10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TAPT1 TLE1 PEG10

2.58e-04192293800edadd1d1ba6b7e0a0398030dd4b61c9c480c7
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 TLE2

2.58e-04192293bf1943715085c4124b1675888b0615c9500ec888
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 GRIK3

2.62e-04193293c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GRIK2 GRIK3 PREX1

2.62e-041932933ea6b103e35bbb276e95301999618558fa3e38b1
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 GRIK3

2.62e-04193293d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellnormal-na-Lymphocytic_B-B_naive|normal / PBMC cell types (v2) per disease, treatment status, and sex

TAPT1 TLE1 PEG10

2.62e-0419329398279a3c69f1df062c4a8333e46c8fd649bf86b1
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 GRIK3

2.62e-041932938b77625bf3c87d39767fb391d1beaca4ab02342b
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 TLE2

2.62e-041932939f9eb241b0b82a6f12de6921c3acf6fed7cf65bb
ToppCellnormal-na-Lymphocytic_B-B_naive-female|normal / PBMC cell types (v2) per disease, treatment status, and sex

TAPT1 TLE1 PEG10

2.62e-04193293dd199163fc13f3d411fe741cf003237064349e22
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 GRIK3

2.62e-04193293010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellsevere_influenza-B_naive|World / disease group, cell group and cell class (v2)

TAPT1 TLE1 PEG10

2.62e-04193293c52ba94782ad57b93d20f853a89344dffa8351f9
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 GRIK3

2.62e-041932933ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 GRIK3

2.62e-041932932189da4b727e25e62669d7b9257f06493be21a27
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 GRIK3

2.62e-04193293e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 GRIK3

2.62e-04193293658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK3 TLE2

2.62e-041932935581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCellsevere_influenza-B_naive|severe_influenza / disease group, cell group and cell class (v2)

TAPT1 TLE1 PEG10

2.66e-041942937c1e9ce5de3bb1657a67010de673c8bb60129cb6
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-8|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TAPT1 TLE1 PEG10

2.66e-04194293e9c907b8ec4329946338cca5ce8e954fa2cec37b
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TAPT1 TLE1 PEG10

2.66e-0419429324f9de4781666c96c4a2d04f8a444543dbd99cbe
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CACNA1A ELOVL6 PEG10

2.66e-04194293f44394c8a6f86483063f2f5722f003a8a0a70254
ToppCellControl-Lymphoid_B-B_naive|Control / Disease group, lineage and cell class

TAPT1 TLE1 PEG10

2.66e-041942934f9600960a287cfc020c06b4af3528d4e5797916
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E CPSF2 TAPT1

2.66e-04194293ad1aacff97beb76f4211942676e1d5e84087d44e
ToppCellCOVID-19_Severe-B_naive|World / disease group, cell group and cell class

TAPT1 TLE1 PEG10

2.66e-04194293d363963a6caeedf4f9e9ad22dcf9b66b85c79a48
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK1 GRIK2 GRIK3

2.66e-041942931bcb3fafd498614f7bac2b1c9b7de56e39110f65
ComputationalIon channels.

GRIK1 GRIK2 GRIK3

2.38e-0470193MODULE_316
Drugriluzole

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

7.50e-08174296CID000005070
Drughexachlorophene

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

9.50e-0890295CID000003598
DrugLY339434

GRIK1 GRIK2 GRIK3

1.55e-079293CID006324635
DrugLY354740

GRIK1 GRIK2 GRIK3 STT3B

5.09e-0751294CID000114827
DrugGYKI 52466

GRIK1 GRIK2 GRIK3 MED23

8.58e-0758294CID000003538
Drugdecahydroisoquinoline

GRIK1 GRIK2 GRIK3

1.03e-0616293CID000097812
Drug5-nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime

GRIK1 GRIK2

1.57e-062292ctd:C084273
DrugLY382884

GRIK1 GRIK2 GRIK3

1.78e-0619293CID000656723
DrugNS 102

GRIK1 GRIK2 GRIK3

2.81e-0622293CID005282252
DrugNSC7524

CACNA1A CACNA1E GRIK1 GRIK3 ITPR3

3.14e-06182295CID000005657
Drugcaffeine

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 STT3B ITPR3

5.24e-06562297CID000002519
Drug2-amino-4-phosphonobutyric acid

CACNA1A CACNA1E GRIK1 GRIK3

5.25e-0691294CID000002207
Drugnitrendipine

CACNA1A CACNA1E GRIK1 ITPR3

7.06e-0698294CID000004507
DrugLY293558

GRIK1 GRIK2 GRIK3

7.37e-0630293CID000127894
Drugisradipine

CACNA1A CACNA1E PEG10 ITPR3

7.65e-06100294CID000003784
Drug4-methylglutamic acid

GRIK1 GRIK2 GRIK3

8.15e-0631293CID000005365
Drugcobalt-60

CACNA1A CACNA1E GRIK1 GRIK3 PEG10 ITPR3

8.27e-06390296CID000061492
Drugcyclothiazide

CACNA1A GRIK1 GRIK2 GRIK3

8.60e-06103294CID000002910
Drugwillardine

GRIK1 GRIK2 GRIK3

8.99e-0632293CID000005123
Drug3-aminopropylphosphinic acid

CACNA1A CACNA1E PEG10

8.99e-0632293CID006335948
DrugAC 110

CACNA1A CACNA1E

9.38e-064292CID000022860
Drugaminothiazole 6

GRIK1 GRIK3

9.38e-064292CID005329388
Drugacromelic acid B

GRIK1 GRIK3

9.38e-064292CID000158974
DrugBrn 1074551

GRIK1 GRIK3

9.38e-064292CID000120220
DrugdiCl-HQC

GRIK1 GRIK3

9.38e-064292CID003018579
DrugCNS 1145

CACNA1A CACNA1E ITPR3

9.88e-0633293CID000190902
DrugIHC-64

CACNA1A CACNA1E ITPR3

9.88e-0633293CID000162753
DrugDB08464

TLE5 TLE1 TLE2 PEG10

1.24e-05113294CID011373270
Druglamotrigine

CACNA1A CACNA1E GRIK1 ITPR3

1.38e-05116294CID000003878
Drug8-cyclopentyltheophylline

CACNA1A CACNA1E GRIK1

1.52e-0538293CID000001917
DrugL-BMAA

GRIK1 GRIK2 GRIK3

1.52e-0538293CID000028558
Drug3-hydroxy-2-quinoxalinecarboxylic acid

GRIK1 GRIK3

1.56e-055292CID000071001
Drugbromowillardiine

GRIK1 GRIK3

1.56e-055292CID000167842
Drugipenoxazone

GRIK1 GRIK3

1.56e-055292CID000065882
DrugpBB-PzDA

GRIK1 GRIK3

1.56e-055292CID000124528
DrugDETC-MeSO

GRIK1 GRIK2 GRIK3

1.65e-0539293CID003035711
DrugJoro spider toxin

GRIK1 GRIK2 GRIK3

2.22e-0543293CID000119582
Drug3-acetylisoquinoline

GRIK1 GRIK3

2.34e-056292CID000124656
Drug3,4-dihydroquinazoline

CACNA1A CACNA1E

2.34e-056292CID000583065
Drugalpha-sialylcholesterol

CACNA1A CACNA1E

2.34e-056292CID000133976
Druggamma-aminobutyric acid

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

2.49e-05474296CID000000119
Drugphilanthotoxin

GRIK1 GRIK2 GRIK3

2.54e-0545293CID000115201
Drugfluorocyclobutane

GRIK1 GRIK3

3.28e-057292CID011051569
DrugAPMPA

CACNA1A CACNA1E

3.28e-057292CID000512300
DrugDantrolene-13C3

CACNA1A CACNA1E GRIK1 ITPR3

3.31e-05145294CID000002951
Drugnimodipine

CACNA1A CACNA1E GRIK1 ITPR3

3.31e-05145294CID000004497
DrugAC1L1DXE

CACNA1A CACNA1E GRIK1 GRIK3 ITPR3

3.46e-05299295CID000002548
DrugAC1L1FA8

GRIK1 GRIK2 GRIK3

3.50e-0550293CID000003150
DrugAC1L1EKQ

GRIK1 GRIK2 GRIK3

3.94e-0552293CID000002834
DrugN-Ac-D-E

GRIK1 GRIK2 STT3B

4.17e-0553293CID000005255
DrugAC1L1B65

GRIK1 GRIK3

4.37e-058292CID000001300
Drugperzinfotel

GRIK1 GRIK3

4.37e-058292CID006918236
DrugCinildipine

CACNA1A CACNA1E ITPR3

4.92e-0556293CID000002752
DrugSR 48968

CACNA1E GRIK1 PEG10

5.47e-0558293CID000104974
Drugmyo-inositol

CACNA1A CACNA1E GRIK1 AVPR2 PREX1 MAP3K4 ITPR3

5.57e-05811297CID000000892
DrugLy294486

GRIK1 GRIK3

5.61e-059292CID005311255
Drug1m5b

GRIK1 GRIK2

5.61e-059292CID000447081
Drugbenzo(F)quinoxaline

GRIK1 GRIK3

5.61e-059292CID000098494
Druggabapentin

CACNA1A CACNA1E GRIK1 ITPR3

6.02e-05169294CID000003446
Drugnilvadipine

CACNA1A CACNA1E ITPR3

6.05e-0560293CID000004494
DrugIAA-94

CACNA1A CACNA1E ITPR3

6.36e-0561293CID000003667
Drug3,7-diaminoheptan-2-one

GRIK1 GRIK2 GRIK3

6.36e-0561293CID004477684
DrugEGTA-AM

CACNA1A CACNA1E GRIK1

6.68e-0562293CID000121907
DrugHFPA

GRIK1 GRIK3

7.00e-0510292CID003035614
Drug2bvx

STAM ELOVL6

7.00e-0510292CID011957382
DrugBenzoates

GRIK1 GRIK2

7.00e-0510292ctd:D001565
Druglercanidipine

CACNA1A CACNA1E ITPR3

7.01e-0563293CID000065866
Drugpapaverine

CACNA1A CACNA1E PEG10 ITPR3

7.05e-05176294CID000004680
DrugAC1L3VFE

TLE5 TLE2 TLE3

7.70e-0565293CID000122880
Druggallopamil

CACNA1A CACNA1E ITPR3

8.43e-0567293CID000001234
Drugsym 2206

GRIK1 GRIK3

8.55e-0511292CID005039877
Drugleys

CACNA1A CACNA1E

8.55e-0511292CID000484683
DrugDCG-IV

CACNA1A CACNA1E GRIK1

8.81e-0568293CID000115114
DrugL-Glutamic Acid

GRIK1 GRIK2 GRIK3

8.81e-0568293DB00142
DrugAC1L2AC7

CACNA1A CACNA1E ITPR3

9.20e-0569293CID000068733
Drugfelbamate

GRIK1 GRIK2 GRIK3

9.60e-0570293CID000003331
Drugbaclofen

CACNA1A CACNA1E GRIK1 ITPR3

9.67e-05191294CID000002284
DrugAC1L2VU3

CACNA1A CACNA1E

1.03e-0412292CID000129572
DrugAtpa

GRIK1 GRIK3

1.03e-0412292CID000002252
Drugnovobiocin sodium, USP; Down 200; 100uM; SKMEL5; HG-U133A

TLE2 TLE3 MAP3K4 ITPR3

1.05e-04195294632_DN
DrugCAS 298-57-7

CACNA1A CACNA1E ITPR3

1.09e-0473293CID000002761
DrugCarteolol hydrochloride [51781-21-6]; Down 200; 12.2uM; PC3; HT_HG-U133A

CACNA1A GRIK2 TLE2 TLE3

1.09e-041972944096_DN
Drugvalproate

CACNA1A CACNA1E GRIK1 TLE5 ITPR3

1.09e-04381295CID000003121
DrugBromopride [4093-35-0]; Up 200; 11.6uM; PC3; HT_HG-U133A

TLE1 TLE2 TLE4 ITPR3

1.11e-041982944278_UP
Druggadolinium

CACNA1A CACNA1E ELOVL6 ITPR3

1.13e-04199294CID000023982
Drug1,3-dipropylxanthine

CACNA1A CACNA1E GRIK1

1.13e-0474293CID000169317
Drugethosuximide

CACNA1A CACNA1E ITPR3

1.13e-0474293CID000003291
DrugAC1L1E5T

GRIK1 GRIK2 GRIK3

1.13e-0474293CID000002653
DrugAC1L1DME

GRIK1 GRIK2 GRIK3

1.18e-0475293CID000002414
Drugglufosinate

CACNA1A CACNA1E TLE5

1.23e-0476293CID000004794
Drughaloperidol

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3

1.28e-04394295CID000003559
Drugnisoldipine

CACNA1A CACNA1E ITPR3

1.33e-0478293CID000004499
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA1A CACNA1E ITPR3

1.38e-0479293CID005287890
DrugN-methyl-DL-aspartic acid

CACNA1A CACNA1E GRIK1 GRIK2 GRIK3 ITPR3

1.50e-04655296CID000004376
Drugnifedipine

CACNA1A CACNA1E GRIK1 GRIK3 ITPR3

1.63e-04415295CID000004485
Drugbutamben

CACNA1A CACNA1E

1.63e-0415292CID000002482
DrugACEA-1011

GRIK1 GRIK3

1.63e-0415292CID000127872
DrugD-N-Q

GRIK1 GRIK2 GRIK3

1.65e-0484293CID000003140
DrugXeC compound

CACNA1E GRIK1 ITPR3

1.65e-0484293CID000005701
DrugAC1L9M5J

CACNA1E GRIK1 GRIK2 GRIK3

1.70e-04221294CID000448615
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1E

2.80e-063292DOID:0111181 (implicated_via_orthology)
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1E

5.59e-064292DOID:6364 (implicated_via_orthology)
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1E

1.95e-057292DOID:0050951 (implicated_via_orthology)
Diseasestroke outcome severity measurement

GRIK2 CPSF2 STT3B

1.91e-04114293EFO_0009603
Diseaseneurodegenerative disease (implicated_via_orthology)

GRIK1 GRIK2 GRIK3

3.87e-04145293DOID:1289 (implicated_via_orthology)
Diseaseunipolar depression, bipolar disorder

CACNA1E GRIK2 GRIK3

4.79e-04156293EFO_0003761, MONDO_0004985
Diseasevolumetric bone mineral density

CACNA1E TLE3

7.84e-0442292EFO_0007620
Diseasecoronary artery calcification

CACNA1E GRIK1 GRIK2 TLE1

9.37e-04450294EFO_0004723
DiseaseBipolar Disorder

CACNA1A GRIK1 GRIK2 AFG1L

1.16e-03477294C0005586
Diseaseendometriosis

CACNA1A GRIK2 MAP3K4

1.91e-03252293EFO_0001065
Diseaseneuroticism measurement, cognitive function measurement

CACNA1E GRIK3 STT3B AFG1L

2.17e-03566294EFO_0007660, EFO_0008354
Diseaselongevity

GRIK2 PREX1 AFG1L

2.68e-03284293EFO_0004300
Diseasecalcium measurement

GRIK2 TLE5 TLE3 TLE4

3.16e-03628294EFO_0004838
DiseaseDystonia

CACNA1A CACNA1E

3.24e-0386292C0013421

Protein segments in the cluster

PeptideGeneStartEntry
TVGKIYAAMMIMEYY

CACNA1A

1951

O00555
ELAMEHRQFYKMSMY

ARSK

316

Q6UWY0
GKIYAAMMIMDYYKQ

CACNA1E

1866

Q15878
YKMGQMFMYDLYQSR

CPSF2

91

Q9P2I0
KQILFMGMMTEYYHY

GRIK1

241

P39086
GKTMVMDMFYAYVEM

AFG1L

141

Q8WV93
MAAYHMNTIYLQEMM

DDX20

806

Q9UHI6
YKAMVMDMEFLYHVG

ITPR3

2311

Q14573
LEHFYMMPVNSEVMY

NUF2

61

Q9BZD4
MDPICDFLYHMKYMF

MED23

1291

Q9ULK4
HYLMHNYPAFMMEMK

PEG10

141

Q86TG7
FMTMNYGVHAVMYSY

ELOVL6

166

Q9H5J4
QALAMGMMTEYYHYI

GRIK2

241

Q13002
MAMGMMTEYYHFIFT

GRIK3

246

Q13003
EEDLHKMLMVYFDYM

MAP3K4

691

Q9Y6R4
YVMIAEKGEKLYHMM

PREX1

406

Q8TCU6
SDMKYHIFQMMMQYL

ABTB2

891

Q8N961
HIFQMMMQYLYYGGT

ABTB2

896

Q8N961
MMQYLYYGGTESMEI

ABTB2

901

Q8N961
MMLKYMHDHYLDKYE

CHSY1

151

Q86X52
MMIKYMHDHYLDKYE

CHSY3

241

Q70JA7
EMQRHYVMYYEMSYG

TLE5

56

Q08117
EMQRHYVMYYEMSYG

TLE1

56

Q04724
MKSHLMVQMGEEYYY

TRAPPC11

451

Q7Z392
TEMQRHYVMYYEMSY

TLE4

61

Q04727
LMYKMSYYRFGEMQL

STT3B

716

Q8TCJ2
YTKLMNEDPMYSMYA

STAM

371

Q92783
EMQRHYVMYYEMSYG

TLE3

56

Q04726
ICYFMMHYVDYSMMY

TAPT1

171

Q6NXT6
MHYVDYSMMYHLIRG

TAPT1

176

Q6NXT6
MQRHYVMYYEMSYGL

TLE2

56

Q04725
VMYYEMSYGLNIEMH

TLE2

61

Q04725
KYLQMVGMYASSYMI

AVPR2

116

P30518