Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.11e-11	26	149	8	GO:0005248
GeneOntologyMolecularFunction	sodium channel activity	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	4.54e-09	52	149	8	GO:0005272
GeneOntologyMolecularFunction	alkali metal ion binding	SCN1A SCN2A SCN3A SCN8A SCN9A PKLR	3.18e-08	26	149	6	GO:0031420
GeneOntologyMolecularFunction	sodium ion binding	SCN1A SCN2A SCN3A SCN8A SCN9A	4.10e-08	14	149	5	GO:0031402
GeneOntologyMolecularFunction	ABC-type xenobiotic transporter activity	ABCC3 ABCC4 ABCB5 ABCB1	3.81e-06	15	149	4	GO:0008559
GeneOntologyMolecularFunction	pyrophosphatase activity	KRAS ABCC3 ABCC4 NRAS ABCB5 RNF213 CCT4 ACYP1 GTPBP10 NLRP3 ABCB1 ARFRP1 SEPTIN3 RAB4B ABCB10 MTIF2 HRAS HFM1 DDX43 HSPA2	4.42e-06	839	149	20	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	KRAS ABCC3 ABCC4 NRAS ABCB5 RNF213 CCT4 ACYP1 GTPBP10 NLRP3 ABCB1 ARFRP1 SEPTIN3 RAB4B ABCB10 MTIF2 HRAS HFM1 DDX43 HSPA2	4.50e-06	840	149	20	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	KRAS ABCC3 ABCC4 NRAS ABCB5 RNF213 CCT4 ACYP1 GTPBP10 NLRP3 ABCB1 ARFRP1 SEPTIN3 RAB4B ABCB10 MTIF2 HRAS HFM1 DDX43 HSPA2	4.50e-06	840	149	20	GO:0016818
GeneOntologyMolecularFunction	xenobiotic transmembrane transporter activity	ABCC3 ABCC4 SLC37A3 ABCB5 ABCB1	5.05e-06	34	149	5	GO:0042910
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	KRAS ABCC3 ABCC4 NRAS ABCB5 RNF213 CCT4 GTPBP10 NLRP3 ABCB1 ARFRP1 SEPTIN3 RAB4B ABCB10 MTIF2 HRAS HFM1 DDX43 HSPA2	5.26e-06	775	149	19	GO:0017111
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC5A8	5.61e-06	171	149	9	GO:0015081
GeneOntologyMolecularFunction	transmembrane transporter activity	ABCC3 ABCC4 SLC37A3 KCNV2 ABCB5 PKD1L2 RYR3 ABCB1 MFSD14A NDUFA12 ABCB10 SLC50A1 SCN1A SLC7A5P2 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC5A8 SLC26A11 ANO3	6.91e-06	1180	149	24	GO:0022857
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ABCC3 ABCC4 SLC37A3 KCNV2 PKD1L2 RYR3 NDUFA12 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC5A8 SLC26A11 ANO3	1.46e-05	758	149	18	GO:0015318
GeneOntologyMolecularFunction	transporter activity	ABCC3 ABCC4 SLC37A3 KCNV2 ABCB5 PKD1L2 RYR3 ABCB1 MFSD14A NDUFA12 ABCB10 SLC50A1 SCN1A SLC7A5P2 SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC5A8 SLC26A11 ANO3	2.96e-05	1289	149	24	GO:0005215
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCC3 ABCC4 ABCB5 ABCB1 ABCB10	3.17e-05	49	149	5	GO:0140359
GeneOntologyMolecularFunction	passive transmembrane transporter activity	KCNV2 PKD1L2 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC5A8 SLC26A11 ANO3	4.10e-05	526	149	14	GO:0022803
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNV2 PKD1L2 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC26A11 ANO3	4.14e-05	459	149	13	GO:0005216
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ABCC4 DHRS11 BDH2 RDH13 CBR4 MDH1B HSD17B8	4.73e-05	127	149	7	GO:0016616
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNV2 PKD1L2 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	5.48e-05	343	149	11	GO:0005261
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH-OH group of donors	ABCC4 DHRS11 BDH2 RDH13 CBR4 MDH1B HSD17B8	8.02e-05	138	149	7	GO:0016614
GeneOntologyMolecularFunction	channel activity	KCNV2 PKD1L2 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC26A11 ANO3	1.60e-04	525	149	13	GO:0015267
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	KCNV2 PKD1L2 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC5A8	1.97e-04	465	149	12	GO:0046873
GeneOntologyMolecularFunction	efflux transmembrane transporter activity	ABCC4 ABCB5 ABCB1	2.12e-04	16	149	3	GO:0015562
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	SCN1A SCN2A SCN10A	2.56e-04	17	149	3	GO:0099508
GeneOntologyMolecularFunction	ABC-type bile acid transporter activity	ABCC3 ABCC4	3.29e-04	4	149	2	GO:0015432
GeneOntologyMolecularFunction	ATPase-coupled organic acid transmembrane transporter activity	ABCC3 ABCC4	3.29e-04	4	149	2	GO:0033283
GeneOntologyMolecularFunction	ATPase-coupled monocarboxylic acid transmembrane transporter activity	ABCC3 ABCC4	3.29e-04	4	149	2	GO:0033285
GeneOntologyMolecularFunction	ATPase-coupled carboxylic acid transmembrane transporter activity	ABCC3 ABCC4	3.29e-04	4	149	2	GO:0033284
GeneOntologyMolecularFunction	ATP hydrolysis activity	ABCC3 ABCC4 ABCB5 RNF213 CCT4 NLRP3 ABCB1 ABCB10 HFM1 DDX43 HSPA2	4.85e-04	441	149	11	GO:0016887
GeneOntologyMolecularFunction	NADH binding	ALDH2 HSD17B8	5.45e-04	5	149	2	GO:0070404
GeneOntologyMolecularFunction	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	SCN5A SCN10A	8.13e-04	6	149	2	GO:0086006
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	KCNV2 PKD1L2 RYR3 NDUFA12 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC5A8	8.59e-04	627	149	13	GO:0022890
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	KCNV2 PKD1L2 RYR3 NDUFA12 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC5A8 SLC26A11 ANO3	8.83e-04	793	149	15	GO:0015075
GeneOntologyMolecularFunction	G protein activity	KRAS NRAS RAB4B HRAS	9.85e-04	59	149	4	GO:0003925
GeneOntologyMolecularFunction	ADP-D-ribose modification-dependent protein binding	MACROH2A1 XRCC1	1.13e-03	7	149	2	GO:0160002
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCC3 ABCC4 ABCB5 ABCB1 ABCB10	1.36e-03	109	149	5	GO:0042626
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	KCNV2 PKD1L2 RYR3 NDUFA12 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC5A8	1.44e-03	664	149	13	GO:0008324
GeneOntologyMolecularFunction	ABC-type glutathione S-conjugate transporter activity	ABCC3 ABCC4	1.50e-03	8	149	2	GO:0015431
GeneOntologyMolecularFunction	phospholipase D activity	GPLD1 PLD6	1.50e-03	8	149	2	GO:0004630
GeneOntologyMolecularFunction	calmodulin binding	MAPKAPK2 RYR3 SCN2A SCN3A SCN5A IQGAP3 SNTB2	1.73e-03	230	149	7	GO:0005516
GeneOntologyMolecularFunction	ATPase-coupled lipid transmembrane transporter activity	ABCC3 ABCC4	1.92e-03	9	149	2	GO:0034040
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCC3 ABCC4 ABCB5 ABCB1 NDUFA12 ABCB10	2.21e-03	178	149	6	GO:0015399
GeneOntologyMolecularFunction	ATP-dependent activity	ABCC3 ABCC4 CENPE ABCB5 RNF213 CCT4 NLRP3 ABCB1 ABCB10 HFM1 DDX43 HSPA2	2.22e-03	614	149	12	GO:0140657
GeneOntologyMolecularFunction	mitogen-activated protein kinase binding	ABL1 MAPKAPK2 EP300	2.24e-03	35	149	3	GO:0051019
GeneOntologyMolecularFunction	ATPase-coupled inorganic anion transmembrane transporter activity	ABCC3 ABCC4	2.39e-03	10	149	2	GO:0043225
GeneOntologyMolecularFunction	NF-kappaB binding	PSMA6 EP300 BRMS1	2.43e-03	36	149	3	GO:0051059
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.40e-10	36	147	8	GO:0086010
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD	1.19e-08	87	147	9	GO:0086001
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.34e-08	62	147	8	GO:0086002
GeneOntologyBiologicalProcess	neuronal action potential	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.53e-08	63	147	8	GO:0019228
GeneOntologyBiologicalProcess	striated muscle contraction	VPS54 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD GAA	5.23e-08	217	147	12	GO:0006941
GeneOntologyBiologicalProcess	membrane depolarization	ABL1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	2.13e-07	121	147	9	GO:0051899
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	3.36e-07	93	147	8	GO:0086003
GeneOntologyBiologicalProcess	cardiac muscle contraction	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD GAA	3.38e-07	167	147	10	GO:0060048
GeneOntologyBiologicalProcess	detection of mechanical stimulus	PDZD7 ADGRV1 PKD1L2 SCN1A SCN9A SCN10A ANO3	1.07e-06	75	147	7	GO:0050982
GeneOntologyBiologicalProcess	transmission of nerve impulse	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.40e-06	112	147	8	GO:0019226
GeneOntologyBiologicalProcess	action potential	KCNV2 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD	1.84e-06	201	147	10	GO:0001508
GeneOntologyBiologicalProcess	actin-mediated cell contraction	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	3.60e-06	127	147	8	GO:0070252
GeneOntologyBiologicalProcess	circulatory system process	ABCC3 ABCC4 DDAH1 ABL1 ARHGEF12 ABCB1 POSTN THRB SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD GAA	4.94e-06	733	147	18	GO:0003013
GeneOntologyBiologicalProcess	heart contraction	THRB SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD GAA	9.88e-06	298	147	11	GO:0060047
GeneOntologyBiologicalProcess	heart process	THRB SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD GAA	1.39e-05	309	147	11	GO:0003015
GeneOntologyBiologicalProcess	actin filament-based movement	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.42e-05	153	147	8	GO:0030048
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD	1.88e-05	208	147	9	GO:0035725
GeneOntologyBiologicalProcess	sodium ion transport	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC5A8 DMD	2.88e-05	275	147	10	GO:0006814
GeneOntologyBiologicalProcess	muscle contraction	VPS54 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD GAA	3.06e-05	400	147	12	GO:0006936
GeneOntologyBiologicalProcess	detection of mechanical stimulus involved in sensory perception	PDZD7 ADGRV1 SCN1A SCN9A SCN10A	5.34e-05	57	147	5	GO:0050974
GeneOntologyBiologicalProcess	blood circulation	DDAH1 ABL1 ARHGEF12 POSTN THRB SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD GAA	6.25e-05	648	147	15	GO:0008015
GeneOntologyBiologicalProcess	response to mechanical stimulus	PDZD7 ADGRV1 PKD1L2 POSTN SCN1A SCN9A SCN10A DMD ANO3	7.18e-05	247	147	9	GO:0009612
GeneOntologyBiologicalProcess	xenobiotic transport	ABCC3 ABCC4 SLC37A3 ABCB5 ABCB1	9.34e-05	64	147	5	GO:0042908
GeneOntologyBiologicalProcess	UDP-N-acetylglucosamine metabolic process	UAP1 GNE B4GALNT2	1.22e-04	14	147	3	GO:0006047
GeneOntologyBiologicalProcess	musculoskeletal movement	VPS54 XRCC1 SCN4A DMD GAA	1.34e-04	69	147	5	GO:0050881
GeneOntologyBiologicalProcess	muscle system process	VPS54 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD EP300 GAA	1.52e-04	547	147	13	GO:0003012
GeneOntologyBiologicalProcess	multicellular organismal movement	VPS54 XRCC1 SCN4A DMD GAA	1.75e-04	73	147	5	GO:0050879
GeneOntologyBiologicalProcess	neuromuscular process	ABL1 VPS54 XRCC1 SCN1A SCN4A DMD HERC1 GAA	2.15e-04	225	147	8	GO:0050905
GeneOntologyBiologicalProcess	detection of external stimulus	PDZD7 ADGRV1 PKD1L2 SCN1A SCN9A SCN10A ANO3	2.46e-04	173	147	7	GO:0009581
GeneOntologyBiologicalProcess	response to abiotic stimulus	KRAS GPLD1 DDAH1 MAPKAPK2 PDZD7 RDH13 ADGRV1 XRCC1 PKD1L2 NLRP3 ABCB1 POSTN SCN1A SCN2A SCN9A SCN10A HRAS PKLR DMD HSPA2 ANO3 EP300	2.58e-04	1361	147	22	GO:0009628
GeneOntologyBiologicalProcess	detection of abiotic stimulus	PDZD7 ADGRV1 PKD1L2 SCN1A SCN9A SCN10A ANO3	2.64e-04	175	147	7	GO:0009582
GeneOntologyBiologicalProcess	nucleotide-sugar metabolic process	UAP1 GNE B4GALNT2 PMM1	2.69e-04	44	147	4	GO:0009225
GeneOntologyBiologicalProcess	negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	MACROH2A1 MACROH2A2	3.00e-04	4	147	2	GO:1901837
GeneOntologyBiologicalProcess	negative regulation of hyaluronan biosynthetic process	AP2A1 CLTC	3.00e-04	4	147	2	GO:1900126
GeneOntologyBiologicalProcess	xenobiotic transmembrane transport	ABCC3 ABCC4 SLC37A3	3.16e-04	19	147	3	GO:0006855
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	ABL1 SLC37A3 KCNV2 PKD1L2 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A SLC5A8 DMD SLC26A11 HSPA2 ANO3	3.39e-04	1017	147	18	GO:0098660
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	ABCC3 ABCC4 ABL1 KCNV2 PKD1L2 RYR3 ABCB1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A DMD SLC26A11 HSPA2 ANO3	3.69e-04	1115	147	19	GO:0034220
GeneOntologyBiologicalProcess	glycoside transport	ABCC3 SLC50A1	4.97e-04	5	147	2	GO:1901656
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.27e-13	17	149	8	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	2.08e-11	29	149	8	GO:0034706
GeneOntologyCellularComponent	cation channel complex	KCNV2 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A HSPA2	1.01e-06	235	149	11	GO:0034703
GeneOntologyCellularComponent	monoatomic ion channel complex	KCNV2 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A HSPA2	8.70e-05	378	149	11	GO:0034702
GeneOntologyCellularComponent	laminin-3 complex	LAMA1 LAMB2	1.51e-04	3	149	2	GO:0005608
GeneOntologyCellularComponent	USH2 complex	PDZD7 ADGRV1	3.00e-04	4	149	2	GO:1990696
GeneOntologyCellularComponent	node of Ranvier	SCN1A SCN2A SCN8A	3.70e-04	20	149	3	GO:0033268
GeneOntologyCellularComponent	transmembrane transporter complex	KCNV2 RYR3 NDUFA12 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A HSPA2	3.78e-04	523	149	12	GO:1902495
GeneOntologyCellularComponent	transporter complex	KCNV2 RYR3 NDUFA12 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A HSPA2	5.91e-04	550	149	12	GO:1990351
GeneOntologyCellularComponent	stereocilia ankle link	PDZD7 ADGRV1	7.43e-04	6	149	2	GO:0002141
GeneOntologyCellularComponent	stereocilia ankle link complex	PDZD7 ADGRV1	7.43e-04	6	149	2	GO:0002142
GeneOntologyCellularComponent	external side of apical plasma membrane	ABCC4 ABCB1	7.43e-04	6	149	2	GO:0098591
GeneOntologyCellularComponent	axon initial segment	SCN1A SCN2A SCN8A	1.13e-03	29	149	3	GO:0043194
GeneOntologyCellularComponent	trans-Golgi network membrane	VPS54 ARFRP1 CLTC COG5 VPS13B	1.25e-03	112	149	5	GO:0032588
GeneOntologyCellularComponent	stereocilia coupling link	PDZD7 ADGRV1	1.37e-03	8	149	2	GO:0002139
GeneOntologyCellularComponent	Barr body	MACROH2A1 MACROH2A2	1.37e-03	8	149	2	GO:0001740
GeneOntologyCellularComponent	plasma membrane protein complex	KCNV2 AP2A1 SCN1A SCN2A SCN3A SCN4A SCN5A CLTC SCN8A SCN9A SCN10A DMD HSPA2 SNTB2	1.49e-03	785	149	14	GO:0098797
GeneOntologyCellularComponent	clathrin complex	CLTC SCN10A	1.76e-03	9	149	2	GO:0071439
GeneOntologyCellularComponent	Golgi membrane	KRAS SGMS2 NRAS ST3GAL3 NLRP3 ABCB1 SLC50A1 HRAS B4GALNT2 TNKS2 COG5 HS3ST2 VPS13B	1.99e-03	721	149	13	GO:0000139
GeneOntologyCellularComponent	sarcomere	MTMR12 PSMA6 RYR3 SCN1A SCN5A SCN8A DMD	2.09e-03	249	149	7	GO:0030017
GeneOntologyCellularComponent	laminin complex	LAMA1 LAMB2	2.19e-03	10	149	2	GO:0043256
GeneOntologyCellularComponent	sarcolemma	RYR3 SCN1A SCN2A SCN5A CLTC DMD	2.44e-03	190	149	6	GO:0042383
GeneOntologyCellularComponent	T-tubule	SCN1A SCN2A SCN5A CLTC	2.46e-03	79	149	4	GO:0030315
GeneOntologyCellularComponent	postsynaptic endocytic zone	AP2A1 CLTC	2.66e-03	11	149	2	GO:0098843
HumanPheno	Linear nevus sebaceous	KRAS NRAS HRAS	2.08e-06	3	66	3	HP:0010817
HumanPheno	Obsessive-compulsive trait	FMO3 ASH1L ADGRV1 SCN1A SCN2A SCN9A	3.16e-06	33	66	6	HP:0008770
HumanPheno	Generalized cerebral atrophy/hypoplasia	ADGRV1 SCN1A SCN2A SCN9A	1.68e-05	13	66	4	HP:0007058
HumanPheno	Nevus sebaceous	KRAS NRAS HRAS	2.04e-05	5	66	3	HP:0010815
HumanPheno	Compulsive behaviors	FMO3 ASH1L ADGRV1 ARID1B SCN1A SCN2A SCN8A SCN9A PDZD8 EP300	2.93e-05	158	66	10	HP:0000722
HumanPheno	Complex febrile seizure	SCN1A SCN2A SCN8A SCN9A	4.16e-05	16	66	4	HP:0011172
HumanPheno	Atypical absence status epilepticus	ADGRV1 SCN1A SCN2A SCN9A	5.39e-05	17	66	4	HP:0011151
HumanPheno	Abnormality of dental color	KRAS NRAS PDZD7 ADGRV1 HRAS	6.52e-05	34	66	5	HP:0011073
HumanPheno	Generalized non-convulsive status epilepticus without coma	ADGRV1 SCN1A SCN2A SCN9A	6.86e-05	18	66	4	HP:0032860
HumanPheno	Non-convulsive status epilepticus without coma	ADGRV1 SCN1A SCN2A SCN9A	1.07e-04	20	66	4	HP:0032671
HumanPheno	Photosensitive myoclonic seizure	SCN1A SCN2A SCN9A	1.11e-04	8	66	3	HP:0001327
HumanPheno	Cyanotic episode	SCN1A SCN2A SCN9A	1.11e-04	8	66	3	HP:0200048
HumanPheno	Abnormal knee physiology	KRAS NRAS ADGRV1 SCN1A SCN2A SCN9A HRAS	1.14e-04	87	66	7	HP:0034670
HumanPheno	Talipes valgus	ADGRV1 SCN1A SCN2A SCN9A	1.30e-04	21	66	4	HP:0004684
HumanPheno	Focal clonic seizure	ST3GAL3 SCN1A SCN2A SCN8A SCN9A	1.84e-04	42	66	5	HP:0002266
HumanPheno	Tibial torsion	ADGRV1 SCN1A SCN2A SCN9A	1.89e-04	23	66	4	HP:0100694
HumanPheno	Focal hemiclonic seizure	SCN1A SCN2A SCN8A SCN9A	2.65e-04	25	66	4	HP:0006813
Domain	Na_channel_asu	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	6.03e-16	10	149	8	IPR001696
Domain	Na_trans_assoc	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	6.03e-16	10	149	8	IPR010526
Domain	Na_trans_assoc	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	6.03e-16	10	149	8	PF06512
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A	2.33e-13	6	149	6	PF11933
Domain	Na_trans_cytopl	SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A	2.33e-13	6	149	6	IPR024583
Domain	Channel_four-helix_dom	KCNV2 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	6.66e-10	57	149	9	IPR027359
Domain	-	KCNV2 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	6.66e-10	57	149	9	1.20.120.350
Domain	Ion_trans_dom	KCNV2 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	2.58e-08	114	149	10	IPR005821
Domain	Ion_trans	KCNV2 RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	2.58e-08	114	149	10	PF00520
Domain	IQ_motif_EF-hand-BS	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A IQGAP3	4.19e-08	90	149	9	IPR000048
Domain	IQ	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A IQGAP3	5.59e-08	93	149	9	PS50096
Domain	IQ	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A IQGAP3	2.67e-07	81	149	8	SM00015
Domain	P-loop_NTPase	KRAS ABCC3 ABCC4 NRAS CENPE ABCB5 RNF213 GTPBP10 NLRP3 ABCB1 ARFRP1 SEPTIN3 RAB4B ABCB10 MTIF2 UCKL1 HRAS HFM1 DDX43 PALS2 HS3ST2 HYDIN	1.03e-06	848	149	22	IPR027417
Domain	ABC_membrane	ABCC3 ABCC4 ABCB5 ABCB1 ABCB10	1.14e-06	24	149	5	PF00664
Domain	IQ	SCN1A SCN3A SCN4A SCN8A SCN9A SCN10A IQGAP3	1.55e-06	71	149	7	PF00612
Domain	-	KRAS ABCC3 ABCC4 NRAS ABCB5 RNF213 GTPBP10 ABCB1 ARFRP1 SEPTIN3 RAB4B ABCB10 MTIF2 UCKL1 HRAS HFM1 DDX43 PALS2 HS3ST2 HYDIN	2.05e-06	746	149	20	3.40.50.300
Domain	ABC_TM1F	ABCC3 ABCC4 ABCB5 ABCB1 ABCB10	2.56e-06	28	149	5	PS50929
Domain	ABC1_TM_dom	ABCC3 ABCC4 ABCB5 ABCB1 ABCB10	2.56e-06	28	149	5	IPR011527
Domain	Sc_DH/Rdtase_CS	DHRS11 BDH2 RDH13 CBR4 HSD17B8	8.09e-06	35	149	5	IPR020904
Domain	ABC_transporter_CS	ABCC3 ABCC4 ABCB5 ABCB1 ABCB10	2.03e-05	42	149	5	IPR017871
Domain	ABC_tran	ABCC3 ABCC4 ABCB5 ABCB1 ABCB10	3.92e-05	48	149	5	PF00005
Domain	ABC_TRANSPORTER_2	ABCC3 ABCC4 ABCB5 ABCB1 ABCB10	3.92e-05	48	149	5	PS50893
Domain	ABC_TRANSPORTER_1	ABCC3 ABCC4 ABCB5 ABCB1 ABCB10	4.34e-05	49	149	5	PS00211
Domain	ABC_transporter-like	ABCC3 ABCC4 ABCB5 ABCB1 ABCB10	4.79e-05	50	149	5	IPR003439
Domain	Core_histone_macro-H2A	MACROH2A1 MACROH2A2	6.32e-05	2	149	2	IPR021171
Domain	ADH_SHORT	DHRS11 BDH2 RDH13 CBR4 HSD17B8	6.37e-05	53	149	5	PS00061
Domain	adh_short	DHRS11 BDH2 RDH13 CBR4 HSD17B8	7.62e-05	55	149	5	PF00106
Domain	SDR_fam	DHRS11 BDH2 RDH13 CBR4 HSD17B8	8.32e-05	56	149	5	IPR002347
Domain	SHR-BD	VPS13D VPS13B	3.75e-04	4	149	2	IPR009543
Domain	VPS13_C	VPS13D VPS13B	3.75e-04	4	149	2	PF16909
Domain	VPS13_C	VPS13D VPS13B	3.75e-04	4	149	2	IPR031645
Domain	SHR-BD	VPS13D VPS13B	3.75e-04	4	149	2	PF06650
Domain	AAA	ABCC3 ABCC4 ABCB5 RNF213 ABCB1 ABCB10	1.05e-03	144	149	6	SM00382
Domain	AAA+_ATPase	ABCC3 ABCC4 ABCB5 RNF213 ABCB1 ABCB10	1.05e-03	144	149	6	IPR003593
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	6.70e-11	31	109	8	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	8.88e-11	32	109	8	M27455
Pathway	REACTOME_L1CAM_INTERACTIONS	LAMA1 AP2A1 SCN1A SCN2A SCN3A SCN4A SCN5A CLTC SCN8A SCN9A SCN10A	2.22e-09	121	109	11	M872
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	KRAS ABL1 NRAS PSMA6 LAMA1 ARHGEF12 RPS28 ADGRV1 PFN1 DSCAML1 AP2A1 SCN1A SCN2A SCN3A SCN4A SCN5A CLTC SCN8A SCN9A SCN10A HRAS	2.44e-09	575	109	21	M29853
Pathway	REACTOME_MUSCLE_CONTRACTION	RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A ALDH2 DMD	4.72e-07	203	109	11	M5485
Pathway	REACTOME_CARDIAC_CONDUCTION	RYR3 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	7.15e-07	130	109	9	M27454
Pathway	WP_DRAVET_SYNDROME	RICTOR SCN1A SCN2A SCN3A SCN8A	2.15e-06	28	109	5	M45519
Pathway	REACTOME_P38MAPK_EVENTS	KRAS NRAS MAPKAPK2 HRAS	2.29e-06	13	109	4	M1441
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS ABL1 NRAS HRAS	3.19e-06	14	109	4	M47364
Pathway	REACTOME_ACTIVATION_OF_RAS_IN_B_CELLS	KRAS NRAS HRAS	4.45e-06	5	109	3	M26921
Pathway	REACTOME_ESTROGEN_STIMULATED_SIGNALING_THROUGH_PRKCZ	KRAS NRAS HRAS	8.84e-06	6	109	3	M27951
Pathway	KEGG_MEDICUS_VARIANT_LOSS_OF_RASSF1_TO_RAS_RASSF1_SIGNALING_PATHWAY	KRAS NRAS HRAS	8.84e-06	6	109	3	M47433
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RAS_UBIQUITINATION_BY_CUL3_COMPLEX	KRAS NRAS HRAS	8.84e-06	6	109	3	M47931
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_SPRED_AND_NF1	KRAS NRAS HRAS	8.84e-06	6	109	3	M47932
Pathway	REACTOME_SHC_MEDIATED_CASCADE_FGFR3	KRAS NRAS HRAS FGF5	9.52e-06	18	109	4	M27518
Pathway	REACTOME_FRS_MEDIATED_FGFR3_SIGNALING	KRAS NRAS HRAS FGF5	1.49e-05	20	109	4	M27519
Pathway	REACTOME_SIGNALLING_TO_RAS	KRAS NRAS MAPKAPK2 HRAS	1.49e-05	20	109	4	M12256
Pathway	WP_SEROTONIN_RECEPTOR_2_AND_ELKSRFGATA4_SIGNALING	KRAS NRAS MAPKAPK2 HRAS	1.49e-05	20	109	4	M39485
Pathway	REACTOME_RAS_SIGNALING_DOWNSTREAM_OF_NF1_LOSS_OF_FUNCTION_VARIANTS	KRAS NRAS HRAS	1.54e-05	7	109	3	M29717
Pathway	REACTOME_SOS_MEDIATED_SIGNALLING	KRAS NRAS HRAS	1.54e-05	7	109	3	M19489
Pathway	REACTOME_P38MAPK_EVENTS	KRAS MAPKAPK2 HRAS	1.54e-05	7	109	3	MM14672
Pathway	REACTOME_SHC_MEDIATED_CASCADE_FGFR1	KRAS NRAS HRAS FGF5	1.83e-05	21	109	4	M27511
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	KRAS NRAS HRAS EP300	1.83e-05	21	109	4	M27485
Pathway	KEGG_ABC_TRANSPORTERS	ABCC3 ABCC4 ABCB5 ABCB1 ABCB10	2.15e-05	44	109	5	M11911
Pathway	REACTOME_ACTIVATED_NTRK3_SIGNALS_THROUGH_RAS	KRAS NRAS HRAS	2.45e-05	8	109	3	M27919
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_RASGAP	KRAS NRAS HRAS	2.45e-05	8	109	3	M47935
Pathway	REACTOME_FRS_MEDIATED_FGFR1_SIGNALING	KRAS NRAS HRAS FGF5	2.67e-05	23	109	4	M27513
Pathway	REACTOME_SIGNALING_BY_MET	KRAS NRAS LAMA1 LAMB2 RAB4B HRAS	3.27e-05	79	109	6	M27643
Pathway	REACTOME_EGFR_TRANSACTIVATION_BY_GASTRIN	KRAS NRAS HRAS	3.65e-05	9	109	3	M27156
Pathway	REACTOME_SHC_RELATED_EVENTS_TRIGGERED_BY_IGF1R	KRAS NRAS HRAS	3.65e-05	9	109	3	M27173
Pathway	REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_RAS	KRAS NRAS HRAS	3.65e-05	9	109	3	M27904
Pathway	REACTOME_FRS_MEDIATED_FGFR2_SIGNALING	KRAS NRAS HRAS FGF5	3.77e-05	25	109	4	M27517
Pathway	REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR3	KRAS NRAS HRAS FGF5	3.77e-05	25	109	4	M27520
Pathway	REACTOME_SIGNALING_BY_FGFR4_IN_DISEASE	KRAS NRAS HRAS	7.09e-05	11	109	3	M27535
Pathway	KEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	7.09e-05	11	109	3	M47370
Pathway	KEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	7.09e-05	11	109	3	M47371
Pathway	REACTOME_ACTIVATED_NTRK2_SIGNALS_THROUGH_FRS2_AND_FRS3	KRAS NRAS HRAS	7.09e-05	11	109	3	M27911
Pathway	REACTOME_MET_ACTIVATES_RAS_SIGNALING	KRAS NRAS HRAS	7.09e-05	11	109	3	M27740
Pathway	REACTOME_CONSTITUTIVE_SIGNALING_BY_OVEREXPRESSED_ERBB2	KRAS NRAS HRAS	7.09e-05	11	109	3	M29814
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RALGDS_SIGNALING_PATHWAY	KRAS NRAS HRAS	7.09e-05	11	109	3	M47436
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RASSF1_SIGNALING_PATHWAY	KRAS NRAS HRAS	7.09e-05	11	109	3	M47432
Pathway	REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR2	KRAS NRAS HRAS FGF5	7.94e-05	30	109	4	M27515
Pathway	REACTOME_SIGNALING_BY_NTRKS	KRAS NRAS MAPKAPK2 AP2A1 CLTC HRAS EP300	7.98e-05	134	109	7	M3574
Pathway	REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR1	KRAS NRAS HRAS FGF5	9.06e-05	31	109	4	M27510
Pathway	KEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	9.40e-05	12	109	3	M47369
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	9.40e-05	12	109	3	M47815
Pathway	REACTOME_SIGNALLING_TO_RAS	KRAS MAPKAPK2 HRAS	9.40e-05	12	109	3	MM14657
Pathway	WP_ENTEROHEPATIC_CIRCULATION_OF_BILE_ACIDS	ABCC3 ABCC4 ABCB1	9.40e-05	12	109	3	M48096
Pathway	REACTOME_SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS	KRAS NRAS HRAS	9.40e-05	12	109	3	M29851
Pathway	WP_RALA_DOWNSTREAM_REGULATED_GENES	KRAS NRAS HRAS	9.40e-05	12	109	3	M39408
Pathway	WP_PI3KAKTMTOR_SIGNALING_AND_THERAPEUTIC_OPPORTUNITIES_IN_PROSTATE_CANCER	KRAS NRAS RICTOR HRAS	1.03e-04	32	109	4	M39445
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.22e-04	13	109	3	M47594
Pathway	REACTOME_SIGNALING_BY_NTRK1_TRKA	KRAS MAPKAPK2 AP2A1 CLTC HRAS	1.24e-04	63	109	5	MM14714
Pathway	WP_ADHD_AND_AUTISM_ASD_PATHWAYS	ABL1 RICTOR SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A ALDH2	1.26e-04	367	109	11	M48346
Pathway	PID_MAPK_TRK_PATHWAY	KRAS NRAS MAPKAPK2 HRAS	1.31e-04	34	109	4	M270
Pathway	REACTOME_SIGNALLING_TO_ERKS	KRAS NRAS MAPKAPK2 HRAS	1.31e-04	34	109	4	M13881
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	ABCC3 ABCC4 ABCB5 PSMA6 ABCB1 ABCB10	1.45e-04	103	109	6	M758
Pathway	KEGG_MEDICUS_REFERENCE_FGF_FGFR_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS FGF5	1.47e-04	35	109	4	M47379
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.54e-04	14	109	3	M47365
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.54e-04	14	109	3	M47366
Pathway	KEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.54e-04	14	109	3	M47390
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.54e-04	14	109	3	M47378
Pathway	REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING	KRAS NRAS HRAS	1.54e-04	14	109	3	M569
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_RAS	KRAS NRAS HRAS	1.54e-04	14	109	3	M27908
Pathway	REACTOME_PTK6_REGULATES_RHO_GTPASES_RAS_GTPASE_AND_MAP_KINASES	KRAS NRAS HRAS	1.54e-04	14	109	3	M27734
Pathway	PID_TCR_RAS_PATHWAY	KRAS NRAS HRAS	1.54e-04	14	109	3	M134
Pathway	KEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.54e-04	14	109	3	M47488
Pathway	REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING	KRAS NRAS HRAS	1.54e-04	14	109	3	M719
Pathway	REACTOME_CONSTITUTIVE_SIGNALING_BY_EGFRVIII	KRAS NRAS HRAS	1.91e-04	15	109	3	M29701
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47367
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47389
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47375
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47380
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47592
Pathway	KEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47593
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47640
Pathway	KEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47485
Pathway	KEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47473
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47474
Pathway	KEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47475
Pathway	KEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47480
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47495
Pathway	KEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47496
Pathway	KEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47497
Pathway	KEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47472
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47535
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	1.91e-04	15	109	3	M47531
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	KRAS ABL1 NRAS PSMA6 LAMA1 ARHGEF12 RPS28 ADGRV1 PFN1 DSCAML1 ARID1B AP2A1 SCN1A SCN2A SCN3A SCN4A SCN5A CLTC SCN8A SCN9A SCN10A HRAS PKLR EP300	2.00e-04	1432	109	24	M509
Pathway	REACTOME_SIGNALING_BY_FGFR1_IN_DISEASE	KRAS NRAS HRAS FGF5	2.04e-04	38	109	4	M27536
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	2.34e-04	16	109	3	M47363
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	2.34e-04	16	109	3	M47373
Pathway	KEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	2.34e-04	16	109	3	M47381
Pathway	KEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	2.34e-04	16	109	3	M47804
Pathway	KEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	2.34e-04	16	109	3	M47801
Pathway	REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING	KRAS NRAS HRAS	2.34e-04	16	109	3	M562
Pathway	REACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS	KRAS NRAS HRAS	2.34e-04	16	109	3	M41733
Pathway	KEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY	KRAS NRAS HRAS	2.34e-04	16	109	3	M47682
Pathway	REACTOME_SIGNALING_BY_ERBB2_ECD_MUTANTS	KRAS NRAS HRAS	2.34e-04	16	109	3	M29847
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY	KRAS NRAS HRAS	2.34e-04	16	109	3	M47483
Pathway	REACTOME_SIGNALING_BY_FGFR3	KRAS NRAS HRAS FGF5	2.49e-04	40	109	4	M27532
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	9.90e-19	9	152	8	16382098
Pubmed	A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.	SCN1A SCN2A SCN3A SCN8A SCN9A SCN10A	6.31e-15	6	152	6	23652591
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN1A SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A	4.45e-14	13	152	7	15123669
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A	5.24e-13	9	152	6	15746173
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN2A SCN3A SCN4A SCN5A SCN8A	1.49e-12	5	152	5	17724025
Pubmed	Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.	SCN1A SCN4A SCN5A DMD SNTB2	8.27e-11	8	152	5	9412493
Pubmed	Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.	SCN1A SCN2A SCN3A SCN8A	3.51e-10	4	152	4	17537961
Pubmed	Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.	SCN1A SCN2A SCN3A SCN8A	3.51e-10	4	152	4	35031483
Pubmed	Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.	SCN1A SCN2A SCN3A SCN8A	3.51e-10	4	152	4	29578003
Pubmed	Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.	KRAS ABL1 NRAS HRAS	3.51e-10	4	152	4	25999467
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN1A SCN2A SCN3A SCN5A SCN8A	1.15e-09	12	152	5	30175250
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	SCN1A SCN2A SCN3A SCN9A	1.75e-09	5	152	4	8812438
Pubmed	Early development of electrical excitability in the mouse enteric nervous system.	SCN3A SCN5A SCN8A SCN9A	1.75e-09	5	152	4	22875929
Pubmed	Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.	ABL1 SCN3A SCN9A SCN10A	4.34e-08	9	152	4	8854872
Pubmed	Diagnostic Value of RAS Mutations in Indeterminate Thyroid Nodules.	KRAS NRAS HRAS	8.18e-08	3	152	3	28116986
Pubmed	Mutations of RAS gene family in specimens of bladder cancer.	KRAS NRAS HRAS	8.18e-08	3	152	3	19101897
Pubmed	Promoter hypomethylation as potential confounder of Ras gene overexpression and their clinical significance in subsets of urothelial carcinoma of bladder.	KRAS NRAS HRAS	8.18e-08	3	152	3	33620658
Pubmed	A comprehensive survey of Ras mutations in cancer.	KRAS NRAS HRAS	8.18e-08	3	152	3	22589270
Pubmed	A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation.	KRAS NRAS HRAS	8.18e-08	3	152	3	23496764
Pubmed	Distribution of p21ras during primary palate formation of non-cleft and cleft strains of mice.	KRAS NRAS HRAS	8.18e-08	3	152	3	7776260
Pubmed	Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.	KRAS NRAS HRAS	8.18e-08	3	152	3	25788415
Pubmed	Sodium channels SCN1A, SCN2A and SCN3A in familial autism.	SCN1A SCN2A SCN3A	8.18e-08	3	152	3	12610651
Pubmed	Comparison of liver oncogenic potential among human RAS isoforms.	KRAS NRAS HRAS	8.18e-08	3	152	3	26799184
Pubmed	Ras isoforms: signaling specificities in CD40 pathway.	KRAS NRAS HRAS	8.18e-08	3	152	3	31906952
Pubmed	Partial functional overlap of the three ras genes in mouse embryonic development.	KRAS NRAS HRAS	8.18e-08	3	152	3	18059342
Pubmed	Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.	SCN3A SCN9A SCN10A	8.18e-08	3	152	3	19699781
Pubmed	Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.	SCN1A SCN2A SCN3A	8.18e-08	3	152	3	18784617
Pubmed	Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series.	KRAS NRAS HRAS	8.18e-08	3	152	3	23240926
Pubmed	Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.	SCN1A SCN2A SCN8A	8.18e-08	3	152	3	28518218
Pubmed	Absolute Quantification of Endogenous Ras Isoform Abundance.	KRAS NRAS HRAS	8.18e-08	3	152	3	26560143
Pubmed	Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma.	KRAS NRAS HRAS	8.18e-08	3	152	3	17712732
Pubmed	Comprehensive survey of HRAS, KRAS, and NRAS mutations in proliferative thyroid lesions from an ethnically diverse population.	KRAS NRAS HRAS	8.18e-08	3	152	3	24222113
Pubmed	Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis.	KRAS NRAS HRAS	8.18e-08	3	152	3	22945650
Pubmed	Activation of RAS family genes in urothelial carcinoma.	KRAS NRAS HRAS	8.18e-08	3	152	3	19303097
Pubmed	The spatiotemporal regulation of RAS signalling.	KRAS NRAS HRAS	8.18e-08	3	152	3	27911734
Pubmed	Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients.	KRAS NRAS HRAS	8.18e-08	3	152	3	20150643
Pubmed	K-ras is an essential gene in the mouse with partial functional overlap with N-ras.	KRAS NRAS HRAS	8.18e-08	3	152	3	9334313
Pubmed	Voltage-gated sodium channels in taste bud cells.	SCN2A SCN3A SCN9A	8.18e-08	3	152	3	19284629
Pubmed	RAS gene mutations and histomorphometric measurements in oral squamous cell carcinoma.	KRAS NRAS HRAS	8.18e-08	3	152	3	37013448
Pubmed	Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).	SCN1A SCN3A SCN9A	8.18e-08	3	152	3	33895391
Pubmed	SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.	SCN1A SCN2A SCN3A	8.18e-08	3	152	3	23859570
Pubmed	Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.	KRAS NRAS HRAS	8.18e-08	3	152	3	25977330
Pubmed	The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.	KRAS NRAS HRAS	8.18e-08	3	152	3	28630043
Pubmed	Overexpression of wild-type p21Ras plays a prominent role in colorectal cancer.	KRAS NRAS HRAS	8.18e-08	3	152	3	28259994
Pubmed	The variable phenotype and low-risk nature of RAS-positive thyroid nodules.	KRAS NRAS HRAS	8.18e-08	3	152	3	26253102
Pubmed	Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia.	KRAS NRAS HRAS	8.18e-08	3	152	3	16573741
Pubmed	Analysis of k-ras nuclear expression in fibroblasts and mesangial cells.	KRAS NRAS HRAS	8.18e-08	3	152	3	20090846
Pubmed	A pericyte origin of spinal cord scar tissue.	KRAS NRAS HRAS	8.18e-08	3	152	3	21737741
Pubmed	Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.	SCN1A SCN2A SCN3A	8.18e-08	3	152	3	17544618
Pubmed	Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.	SCN1A SCN2A SCN8A	8.18e-08	3	152	3	32845893
Pubmed	Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.	SCN4A SCN5A SCN9A	8.18e-08	3	152	3	20038812
Pubmed	Prevalence of RAS point mutations in papillary thyroid carcinoma; a novel mutation at codon 31 of K-RAS.	KRAS NRAS HRAS	8.18e-08	3	152	3	17943694
Pubmed	Deciphering the RAS/ERK pathway in vivo.	KRAS NRAS HRAS	8.18e-08	3	152	3	28202657
Pubmed	Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.	KRAS NRAS HRAS	8.18e-08	3	152	3	16761621
Pubmed	Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.	SCN1A SCN2A SCN8A	8.18e-08	3	152	3	17928448
Pubmed	Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.	SCN1A SCN2A SCN3A	8.18e-08	3	152	3	14973256
Pubmed	Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis.	KRAS NRAS HRAS	8.18e-08	3	152	3	20971740
Pubmed	Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma.	KRAS NRAS HRAS	8.18e-08	3	152	3	27119512
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	KRAS UAP1 NRAS PSMA6 GART ASH1L RICTOR CCT4 PFN1 ARID1B AP2A1 CLTC SCN8A PALS2 HSPA2 IQGAP3 HYDIN	1.03e-07	807	152	17	30575818
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DIP2B CPAMD8 ABCC4 MAPKAPK2 ASH1L RNF213 MACROH2A1 VPS54 ST3GAL3 ADGRV1 PFKL SIL1 PCYOX1L KLHL9 TRNT1 THRB SUGP2 UCKL1 MACROH2A2 PALS2 EP300 VPS13B BRMS1	1.45e-07	1489	152	23	28611215
Pubmed	Ras effectors and their role in mitogenesis and oncogenesis.	KRAS NRAS MAPKAPK2 HRAS	1.69e-07	12	152	4	9297626
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MTMR12 RNF213 RICTOR CCT4 ITPRID2 XRCC1 PAF1 POSTN ARID1B KLHL15 CLTC EFR3B PDZD8 NHS MACROH2A2 DMD HERC1 HSPA2 SNTB2	1.81e-07	1049	152	19	27880917
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNV2 SCN1A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.92e-07	139	152	8	16985003
Pubmed	Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.	SCN1A SCN2A SCN3A	3.26e-07	4	152	3	35801810
Pubmed	Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.	KRAS NRAS HRAS	3.26e-07	4	152	3	10085069
Pubmed	Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice.	KRAS NRAS HRAS	3.26e-07	4	152	3	38849523
Pubmed	Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.	SCN1A SCN2A SCN8A	3.26e-07	4	152	3	21156207
Pubmed	SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.	KRAS NRAS HRAS	3.26e-07	4	152	3	9674433
Pubmed	Quantification of spatiotemporal patterns of Ras isoform expression during development.	KRAS NRAS HRAS	3.26e-07	4	152	3	28117393
Pubmed	Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.	SCN1A SCN2A SCN3A	3.26e-07	4	152	3	8974318
Pubmed	Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.	ARID1B SCN1A SCN2A	3.26e-07	4	152	3	26637798
Pubmed	The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.	KRAS NRAS HRAS	3.26e-07	4	152	3	27936046
Pubmed	Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.	KRAS NRAS HRAS	3.26e-07	4	152	3	29502968
Pubmed	Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.	KRAS NRAS HRAS	3.26e-07	4	152	3	7972015
Pubmed	Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.	SCN1A SCN9A SCN10A	3.26e-07	4	152	3	22260870
Pubmed	Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.	KRAS NRAS HRAS	3.26e-07	4	152	3	10490827
Pubmed	Targeted Long-Read Sequencing Decodes the Transcriptional Atlas of the Founding RAS Gene Family Members.	KRAS NRAS HRAS	3.26e-07	4	152	3	34948093
Pubmed	Ras membrane orientation and nanodomain localization generate isoform diversity.	KRAS NRAS HRAS	3.26e-07	4	152	3	20080631
Pubmed	Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin.	KRAS NRAS HRAS	8.13e-07	5	152	3	22982107
Pubmed	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.	SCN1A SCN2A SCN3A	8.13e-07	5	152	3	24337656
Pubmed	Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector.	KRAS ABL1 NRAS	8.13e-07	5	152	3	10498879
Pubmed	The complexity of Raf-1 regulation.	KRAS NRAS HRAS	8.13e-07	5	152	3	9069260
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	SCN1A SCN2A SCN3A	8.13e-07	5	152	3	1679748
Pubmed	Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.	KRAS NRAS HRAS	8.13e-07	5	152	3	34535655
Pubmed	Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.	KRAS NRAS HRAS	8.13e-07	5	152	3	24746824
Pubmed	Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation.	KRAS NRAS HRAS	8.13e-07	5	152	3	15558479
Pubmed	Efflux protein expression in human stem cell-derived retinal pigment epithelial cells.	ABCC3 ABCC4 ABCB1	8.13e-07	5	152	3	22272278
Pubmed	Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells.	CENPE CCT4 PFN1 CLTC H1-6 DMD HSPA2 VPS13B GAA	1.54e-06	247	152	9	30713523
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	LAMB2 RICTOR GTPBP10 PCYOX1L PREP MTIF2 PDZD8 GAA	1.55e-06	183	152	8	31932471
Pubmed	Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth.	KRAS NRAS HRAS	1.62e-06	6	152	3	29615452
Pubmed	Organization, sequence, chromosomal localization, and promoter identification of the mouse orphan nuclear receptor Nurr1 gene.	ABL1 SCN3A SCN9A	1.62e-06	6	152	3	9143501
Pubmed	Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.	SCN8A SCN9A SCN10A	1.62e-06	6	152	3	16029194
Pubmed	Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf.	KRAS NRAS HRAS	1.62e-06	6	152	3	9753431
Pubmed	An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.	SCN3A SCN8A SCN10A	1.62e-06	6	152	3	23711479
Pubmed	FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.	KRAS NRAS HRAS	1.62e-06	6	152	3	21072204
Pubmed	Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1.	KRAS NRAS HRAS	1.62e-06	6	152	3	10882715
Pubmed	LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases.	KRAS NRAS HRAS	1.62e-06	6	152	3	31337872
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCC3 ABL1 KMT2B SLC37A3 MAPKAPK2 LAMB2 SIL1 AP2A1 SUGP2 UCKL1 SCN5A SCN8A PDZD8 WDFY3 HERC1 IQGAP3 EP300 ZNF687	1.77e-06	1105	152	18	35748872
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	MTMR12 ABL1 ASH1L TENM2 NLRP3 AP2A1 ALDH2 EP300 SNTB2	2.14e-06	257	152	9	30945288
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	DDAH1 BDH2 ARHGEF12 ADGRV1 PFKL PFN1 ABCB1 VPS13D CLTC SCN10A PKLR ALDH2 SLC5A8 SLC26A11 HSPA2 GAA SECTM1	2.45e-06	1016	152	17	19056867
Interaction	SCN11A interactions	SCN1A SCN5A SCN8A SCN9A SCN10A	6.46e-08	15	152	5	int:SCN11A
Interaction	TRPV2 interactions	KRAS NRAS SLC50A1 HRAS	6.31e-07	10	152	4	int:TRPV2
Interaction	NEDD4 interactions	KRAS ABL1 NRAS PFN1 KHSRP ABCB1 SCN1A SCN2A SCN3A SCN5A CLTC SCN8A SCN9A SCN10A HRAS DMD EP300	7.91e-07	544	152	17	int:NEDD4
Interaction	SCN5A interactions	SCN1A SCN5A SCN8A SCN9A SCN10A SNTB2	1.39e-06	47	152	6	int:SCN5A
Interaction	HEPH interactions	KRAS NRAS HRAS	8.27e-06	6	152	3	int:HEPH
Interaction	SCN4B interactions	SCN1A SCN2A SCN8A	2.29e-05	8	152	3	int:SCN4B
Interaction	CACNA1D interactions	SCN1A SCN5A SCN9A SCN10A	2.94e-05	24	152	4	int:CACNA1D
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	ASH1L SLC50A1 PKLR IQGAP3	9.44e-05	71	152	4	chr1q22
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	6.40e-18	9	101	8	1203
GeneFamily	ATP binding cassette subfamily B	ABCB5 ABCB1 ABCB10	2.70e-05	11	101	3	806
GeneFamily	Short chain dehydrogenase/reductase superfamily	DHRS11 BDH2 RDH13 CBR4 HSD17B8	6.64e-05	76	101	5	743
GeneFamily	Fibronectin type III domain containing\|USH2 complex	PDZD7 ADGRV1	1.84e-04	4	101	2	1244
GeneFamily	RAS type GTPase family	KRAS NRAS HRAS	6.79e-04	31	101	3	389
GeneFamily	PDZ domain containing	ARHGEF12 PDZD7 PDZD8 PALS2 SNTB2	1.63e-03	152	101	5	1220
GeneFamily	Laminin subunits	LAMA1 LAMB2	1.97e-03	12	101	2	626
GeneFamily	ATP binding cassette subfamily C	ABCC3 ABCC4	2.32e-03	13	101	2	807
GeneFamily	Beta 4-glycosyltransferases	B4GALNT2 B4GALNT3	3.98e-03	17	101	2	425
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	DMD EP300	4.46e-03	18	101	2	91
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN LAMA1 ADGRV1 PKD1L2 DSCAML1 RYR3 SCN2A SCN9A DMD ANO3 HYDIN	4.16e-11	184	152	11	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN LAMA1 ADGRV1 PKD1L2 DSCAML1 RYR3 SCN2A SCN9A DMD ANO3 HYDIN	4.16e-11	184	152	11	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN LAMA1 ADGRV1 PKD1L2 DSCAML1 RYR3 SCN2A SCN9A DMD ANO3 HYDIN	4.16e-11	184	152	11	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	DIP2B VPS54 ARID1B THRB WDFY3 DMD HERC1 COG5 VPS13B	2.94e-08	199	152	9	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 FMO3 CCDC168 TMEM132C POSTN SCN8A HS3ST2 NOVA1	1.70e-07	176	152	8	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	ABCC3 FMO3 CCDC168 TMEM132C POSTN SCN8A HS3ST2 NOVA1	1.70e-07	176	152	8	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	RICTOR DSCAML1 VPS13D PDZD8 WDFY3 ALDH2 HERC1	2.59e-06	177	152	7	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	ABCC3 ABCC4 DSCAML1 NHS SLC5A8 PALS2 HYDIN	3.35e-06	184	152	7	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 ABCC4 DSCAML1 NHS SLC5A8 PALS2 HYDIN	3.60e-06	186	152	7	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	(04)_Pre-ciliated-(3)_72hpi\|(04)_Pre-ciliated / shred by cell type and Timepoint	NRAS VIT VPS13D CFAP52 MDH1B HSPA2 HYDIN	3.86e-06	188	152	7	f911dc61b008b60aaa2a1e9354085f480a669e2c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 ADGRV1 DSCAML1 NHS PALS2 HYDIN NOVA1	3.86e-06	188	152	7	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	DIP2B AVL9 ADGRV1 CLTC WDFY3 ZNF281 VPS13B	4.59e-06	193	152	7	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 CPAMD8 SGMS2 DSCAML1 SCN2A NHS HYDIN	5.25e-06	197	152	7	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ASH1L RNF213 RICTOR ARID1B SUGP2 HERC1 VPS13B	5.61e-06	199	152	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Neuronal-Excitatory-eF(C1QL3)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DDAH1 VIT B4GALNT3 DMD HS3ST2 ANO3 SNTB2	5.79e-06	200	152	7	7668ae7ed550583ab59e419c5c9bb9f2d7e8e0d5
ToppCell	Neuronal-Excitatory-eF(C1QL3)----L5-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DDAH1 VIT B4GALNT3 DMD HS3ST2 ANO3 SNTB2	5.79e-06	200	152	7	44f0278cb0e4ffcda4af3719d7f5819a10929b9f
ToppCell	Neuronal-Excitatory-eF(C1QL3)---\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DDAH1 VIT B4GALNT3 DMD HS3ST2 ANO3 SNTB2	5.79e-06	200	152	7	23da7790e09575b2ca909ed16806b44223bf1017
ToppCell	Neuronal-Excitatory-eF(C1QL3)-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DDAH1 VIT B4GALNT3 DMD HS3ST2 ANO3 SNTB2	5.79e-06	200	152	7	91f3df1c5a661ff703835f58a35cee93f18eb15c
ToppCell	Neuronal-Excitatory-eF(C1QL3)--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DDAH1 VIT B4GALNT3 DMD HS3ST2 ANO3 SNTB2	5.79e-06	200	152	7	2e2b1d252972b702ade25526ec8461bf613d81b0
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNV2 LAMA1 ADGRV1 DSCAML1 RYR3 HYDIN	1.86e-05	160	152	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	FMO3 CCDC168 TMEM132C POSTN SCN8A HS3ST2	1.86e-05	160	152	6	636127753e3a22831f39d4c8170df40901e4329d
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	FMO3 CCDC168 TMEM132C POSTN SCN8A HS3ST2	1.86e-05	160	152	6	cb8d0dc1a6c69c7a85c5fdd8f0f6cca1b73dfc63
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNV2 LAMA1 ADGRV1 DSCAML1 RYR3 HYDIN	1.86e-05	160	152	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLIN4 ABCB5 VIT TMEM132C FGF5 DMD	1.93e-05	161	152	6	4f25eeabb841b0b9204cdd4e71d5e131e7868184
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLIN4 ABCB5 VIT TMEM132C FGF5 DMD	1.93e-05	161	152	6	a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 LAMA1 DSCAML1 RYR3 NHS HYDIN	2.14e-05	164	152	6	1cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 ABCC4 UAP1 DSCAML1 SCN2A B4GALNT3	2.37e-05	167	152	6	edc5f04584b44f99ff9a62bbe0dab6fc044fb334
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZAN ADGRV1 RYR3 SCN3A SCN9A HYDIN	2.53e-05	169	152	6	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	10x3'2.3-week_17-19-Myeloid_DC-DC-tDC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ZAN PFN1 NDUFA12 SCN9A ALDH2 SECTM1	2.71e-05	171	152	6	b327fb7813a3cdae06c8a4f8a0c256e9a20132f6
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UAP1 LAMB2 VIT THRB SCN2A NOVA1	2.98e-05	174	152	6	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VIT B4GALNT3 DMD HS3ST2 ANO3 SNTB2	3.18e-05	176	152	6	0710689e66deba179b0a8038cdd56b4834984f12
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ST3GAL3 VN1R1 POSTN HFM1 DMD ANO3	3.18e-05	176	152	6	b4a23d8d1414434adeb237a96f28c825f1aebd77
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ST3GAL3 VN1R1 POSTN HFM1 DMD ANO3	3.18e-05	176	152	6	66c9c6b59030f67e8d746a9c6930e50923f2ded1
ToppCell	P15-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	POSTN PCYOX1L SCN8A NHS DMD PALS2	3.18e-05	176	152	6	792f414f5092aba14260b8e16378e793a822498e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VIT B4GALNT3 DMD HS3ST2 ANO3 SNTB2	3.39e-05	178	152	6	6f61490d79cd1727ed2d5cc673823dd4efdafac1
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PCDHA4 PDZD7 ABCB1 SCN2A SCN8A DDX43	3.50e-05	179	152	6	228d12ed1c8dc92aefbcea4aaf7d108783c22be0
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BDH2 IGDCC4 POSTN SCN9A NHS SLC5A8	3.72e-05	181	152	6	af92b8b7f455210dab502ef6964f3a0162180759
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BDH2 TMEM132C POSTN SCN9A NHS HS3ST2	3.72e-05	181	152	6	bd7e9437839bca543ca5945df43d6525e6a312a8
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IGDCC4 TMEM132C POSTN SCN9A NHS SLC5A8	3.95e-05	183	152	6	121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ABCC3 DSCAML1 NHS SLC5A8 PALS2 HYDIN	3.95e-05	183	152	6	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ABCC3 ADGRV1 CLIP4 THRB SCN9A DMD	3.95e-05	183	152	6	c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CPAMD8 DDAH1 ARHGEF12 ADGRV1 EFR3B PALS2	4.08e-05	184	152	6	102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BDH2 TMEM132C POSTN SCN9A EFR3B NHS	4.33e-05	186	152	6	948815663c212c4311329d503b5991cbbbff9808
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	ABCC4 AVL9 ASH1L RNF213 KLHL15 CLTC	4.33e-05	186	152	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 DSCAML1 NHS PALS2 HYDIN NOVA1	4.33e-05	186	152	6	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPTIN3 SCN1A SCN2A SCN8A HS3ST2 ANO3	4.46e-05	187	152	6	7b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 DSCAML1 NHS PALS2 HYDIN NOVA1	4.46e-05	187	152	6	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 ABCB1 THRB SCN2A SCN3A B4GALNT2	4.46e-05	187	152	6	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 ABCC4 ABCB1 NHS PALS2 HYDIN	4.73e-05	189	152	6	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	BDH2 TMEM132C POSTN SCN9A EFR3B NHS	4.73e-05	189	152	6	78cf414b98bcb19deb934409acddaad1cd51b67f
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DIP2B ABCC3 SNX13 KLHL9 CLTC TNKS2	4.73e-05	189	152	6	875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCell	MS-CD8-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	DIP2B MTMR12 NRAS KHSRP KLHL15 SNTB2	4.87e-05	190	152	6	8c831c4560b8e70f92b4c15644fea39f7f7afcf2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 ABCC4 GNE LAMA1 DSCAML1 HYDIN	5.02e-05	191	152	6	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ABCC3 SGMS2 ADGRV1 THRB SCN9A DMD	5.02e-05	191	152	6	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF12 ABCB1 THRB ARHGEF10 SCN9A NOVA1	5.17e-05	192	152	6	c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCell	MS-Treg-exh_CD4\|MS / Condition, Cell_class and T cell subcluster	DIP2B SLC37A3 GART ARHGEF12 KLHL9 ABCB10	5.17e-05	192	152	6	c6722bf142c84ccedd99c1a3344085aecb4cbab4
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF12 ABCB1 THRB ARHGEF10 SCN9A NOVA1	5.32e-05	193	152	6	a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCell	PCW_05-06-Epithelial-Epithelial_airway\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ABCC3 DDAH1 ADGRV1 THRB SCN9A DMD	5.32e-05	193	152	6	af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC3 CPAMD8 ABCC4 RNF213 DSCAML1 HYDIN	5.47e-05	194	152	6	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TENM2 THRB SCN1A SCN2A SCN3A SCN8A	6.13e-05	198	152	6	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TENM2 DSCAML1 SCN2A SCN3A SCN8A NOVA1	6.13e-05	198	152	6	8f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TENM2 THRB SCN1A SCN2A SCN3A SCN8A	6.13e-05	198	152	6	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THRB SCN1A SCN2A SCN3A SCN8A PALS2	6.13e-05	198	152	6	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRV1 ARID1B WDFY3 DMD COG5 VPS13B	6.13e-05	198	152	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THRB SCN2A SCN3A SCN8A HERC1 PALS2	6.13e-05	198	152	6	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TMEM132C SCN1A SCN2A SCN9A RNF128 HYDIN	6.30e-05	199	152	6	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	TENM2 THRB SCN2A SCN3A SCN8A HERC1	6.48e-05	200	152	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ABCC3 CPAMD8 ARHGEF12 ARHGEF10 SCN9A NOVA1	6.48e-05	200	152	6	66f7e8ee63c828f17468e79a4b816346b33e8980
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRV1 SCN1A SCN9A SCN10A HYDIN	1.40e-04	145	152	5	96712c68ab759d7ade0d912581a1a7c25dc6def8
Drug	APETx1, Anthopleura elegantissima	SCN2A SCN3A SCN4A SCN8A SCN10A	7.17e-11	6	151	5	ctd:C475726
Drug	Zonisamide	SCN1A SCN2A SCN3A SCN4A SCN5A SCN9A	8.97e-10	17	151	6	DB00909
Drug	PAK-104P	ABCC3 ABCC4 ABCB5 CCT4 ABCB1	3.42e-08	15	151	5	CID000131368
Drug	5-hydroxypropafenone	ABCB5 ABCB1 SCN3A SCN4A SCN9A SCN10A	8.89e-08	34	151	6	CID000107927
Drug	2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate	SCN2A SCN3A SCN8A SCN10A	1.27e-07	8	151	4	ctd:C489827
Drug	Mexiletine	ABCB1 SCN5A SCN9A SCN10A	2.28e-07	9	151	4	ctd:D008801
Drug	N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide	SCN3A SCN4A SCN9A	2.86e-07	3	151	3	ctd:C561228
Drug	Pirmenolum	SCN3A SCN4A SCN9A SCN10A PKLR	7.06e-07	26	151	5	CID000004853
Drug	AC1L1MOZ	SCN3A SCN4A SCN5A SCN9A SCN10A	8.62e-07	27	151	5	CID000031958
Drug	lamotrigine	RYR3 ABCB1 SCN2A SCN3A SCN4A SCN5A SCN9A SCN10A	1.08e-06	116	151	8	CID000003878
Drug	Lidocaine	SCN5A SCN9A SCN10A	1.14e-06	4	151	3	DB00281
Drug	APETx2 protein, Anthopleura elegantissima	SCN2A SCN8A SCN10A	1.14e-06	4	151	3	ctd:C501880
Drug	L 744832	KRAS NRAS HRAS	1.14e-06	4	151	3	ctd:C096898
Drug	cyfluthrin	THRB SCN2A SCN3A SCN10A HYDIN	1.25e-06	29	151	5	ctd:C052570
Drug	amiodarone	ABCB5 ABCB1 THRB SCN3A SCN4A SCN5A SCN9A SCN10A SLC5A8	1.26e-06	160	151	9	CID000002156
Drug	5-carboxyfluorescein diacetate	ABCC3 ABCB5 SIL1 ABCB1	1.27e-06	13	151	4	CID000133314
Drug	Sodium	SCN2A SCN3A SCN5A SCN8A SCN9A SCN10A SLC5A8	1.45e-06	84	151	7	ctd:D012964
Drug	tocainide	SCN3A SCN4A SCN5A SCN9A SCN10A	1.50e-06	30	151	5	CID000038945
Drug	tetramethylrosamine	ABCC3 ABCC4 ABCB5 ABCB1	1.77e-06	14	151	4	CID000443313
Drug	AC1NSZ76	ABCB5 ABCB1 SLC5A8	2.83e-06	5	151	3	CID005320215
Drug	AC1L4BIC	ABCC3 ABCC4 ABCB5 ABCB1	3.18e-06	16	151	4	CID000153998
Drug	propafenone	ABCB5 ABCB1 SCN3A SCN4A SCN5A SCN9A SCN10A	4.10e-06	98	151	7	CID000004932
Drug	benzocaine	SCN2A SCN3A SCN4A SCN9A SCN10A	4.41e-06	37	151	5	CID000002337
Drug	AC1L1CQC	ABCB1 SCN3A SCN4A SCN5A SCN9A SCN10A	4.61e-06	65	151	6	CID000002012
Drug	procainamide	MACROH2A1 SCN3A SCN4A SCN5A SCN9A SCN10A H1-6 MACROH2A2 WDFY3	5.17e-06	190	151	9	CID000004913
Drug	Scorpion Venoms	SCN2A SCN3A SCN4A SCN9A	5.29e-06	18	151	4	ctd:D012604
Drug	NSC695241	ABCC3 ABCB5 ABCB1	5.64e-06	6	151	3	CID000003584
Drug	fenpropathrin	SCN2A SCN3A SCN10A	5.64e-06	6	151	3	ctd:C044267
Drug	Tetrodotoxin	SCN2A SCN3A SCN5A SCN8A SCN9A	6.55e-06	40	151	5	ctd:D013779
Drug	Apa-sg	ABCC3 ABCC4 ABCB5 ABCB1	6.67e-06	19	151	4	CID000126348
Drug	diprafenone	SCN3A SCN4A SCN9A SCN10A	6.67e-06	19	151	4	CID000071249
Drug	flecainide	RYR3 SCN3A SCN4A SCN5A SCN9A SCN10A	7.73e-06	71	151	6	CID000003355
Drug	O746	ABCC3 ABCC4 ABCB5 ABCB1	8.29e-06	20	151	4	CID006327063
Drug	1, 3-diallylurea	ABCB5 ABCB1 SCN3A SCN4A SCN9A SCN10A	9.84e-06	74	151	6	CID000074537
Drug	lidocaine	RYR3 ABCB1 SCN3A SCN4A SCN5A SCN9A SCN10A DMD	1.18e-05	160	151	8	CID000003676
Drug	amsacrine	ABCC3 ABCC4 ABCB5 ABCB1 ARFRP1	1.18e-05	45	151	5	CID000002179
Drug	AC1Q5X3R	ABCC3 ABCC4 ABCB5 ABCB1	1.24e-05	22	151	4	CID000108075
Drug	VX-710	ABCC3 ABCC4 ABCB5 ABCB1	1.24e-05	22	151	4	CID000406509
Drug	pilsicainide	SCN3A SCN4A SCN5A SCN9A SCN10A	1.32e-05	46	151	5	CID000004820
Drug	hydroxyrubicin	ABCC3 ABCC4 ABCB5 ABCB1	1.49e-05	23	151	4	CID000072398
Drug	calcein AM	ABCC3 ABCC4 ABCB1	1.56e-05	8	151	3	ctd:C085925
Drug	nicotine glucuronide	ABCC3 ABCB5 ABCB1	1.56e-05	8	151	3	CID003035848
Drug	tXMP	ABCC4 ABCB5 ABCB1	1.56e-05	8	151	3	CID003081384
Drug	AC1NT1AF	SCN3A SCN4A SCN9A SCN10A	2.11e-05	25	151	4	CID005322157
Drug	So324	ABCC4 ABCB5 ABCB1	2.33e-05	9	151	3	CID000462261
Drug	AC1L32OA	KRAS NRAS HRAS	2.33e-05	9	151	3	CID000107745
Drug	verapamil	ABCC3 ABCC4 KCNV2 ABCB5 PAF1 RYR3 ABCB1 ABCB10 SCN3A SCN4A SCN5A SCN9A SCN10A	2.45e-05	490	151	13	CID000002520
Drug	carbamazepine	PFKL ABCB1 SCN2A SCN3A SCN4A SCN5A SCN9A SCN10A	2.66e-05	179	151	8	CID000002554
Drug	PbTx-1	SCN3A SCN4A SCN9A SCN10A	2.90e-05	27	151	4	CID006437089
Drug	nefopam	SCN3A SCN4A SCN9A SCN10A	2.90e-05	27	151	4	CID000004450
Drug	thioxanthene	ABCB5 ABCB1 B4GALNT2	3.32e-05	10	151	3	CID000067495
Drug	Texas Red	ABCC3 ABCC4 ABCB5 ABCB1	3.36e-05	28	151	4	CID000452705
Drug	paraben	SCN3A SCN4A SCN9A SCN10A	3.36e-05	28	151	4	CID000007175
Drug	Hexylcaine	SCN5A SCN10A	4.37e-05	2	151	2	DB00473
Drug	mesochlorin e6 monoethylenediamine	ABCB5 ABCB1	4.37e-05	2	151	2	CID005488855
Drug	Ranolazine	SCN5A SCN9A	4.37e-05	2	151	2	DB00243
Drug	Phenytoin	SCN1A SCN5A	4.37e-05	2	151	2	DB00252
Drug	taxuspine C	ABCB5 ABCB1	4.37e-05	2	151	2	CID005321745
Drug	Flecainide	SCN4A SCN5A	4.37e-05	2	151	2	DB01195
Drug	isoprene	KRAS HRAS	4.37e-05	2	151	2	ctd:C005059
Drug	2,2-diphenyl-1,3-dioxolane	ABCB5 ABCB1	4.37e-05	2	151	2	CID000283230
Drug	Ro44-5912	ABCB5 ABCB1	4.37e-05	2	151	2	CID000197370
Drug	mu-conotoxin KIIIA, Conus kinoshitai	SCN2A SCN4A	4.37e-05	2	151	2	ctd:C502265
Drug	8-(3,3-dimethylallyl)chrysin	ABCB5 ABCB1	4.37e-05	2	151	2	CID005281903
Drug	AC1L8LCS	ABCB5 ABCB1	4.37e-05	2	151	2	CID000383419
Drug	sulfurmycin A	ABCB5 ABCB1	4.37e-05	2	151	2	CID000155836
Drug	DAPDOX	ABCB5 ABCB1	4.37e-05	2	151	2	CID000164413
Drug	AC1Q6JJG	ABCB5 ABCB1	4.37e-05	2	151	2	CID000164322
Drug	YM212	ABCB5 ABCB1	4.37e-05	2	151	2	CID000129980
Drug	Ro11-2933	ABCB5 ABCB1	4.37e-05	2	151	2	CID000115215
Drug	cnidiadin	ABCB5 ABCB1	4.37e-05	2	151	2	CID005315980
Drug	conferone	ABCB5 ABCB1	4.37e-05	2	151	2	CID001757335
Drug	oxyberberine	CCT4 ABCB1	4.37e-05	2	151	2	CID000011066
Drug	VX-710-3	ABCB5 ABCB1	4.37e-05	2	151	2	CID006450549
Drug	NAc-LLY-amide	ABCB5 ABCB1	4.37e-05	2	151	2	CID000443109
Drug	62820-12-6	ABCB5 ABCB1	4.37e-05	2	151	2	CID006449905
Drug	edatrexate	ABCC3 ABCC4 GART CCT4	4.45e-05	30	151	4	CID000054586
Drug	AC1L9E0Q	ABCC3 ABCC4 ABCB5 ABCB1	4.45e-05	30	151	4	CID000443095
Drug	salbutamol	ARHGEF12 PAF1 SCN3A SCN4A CLTC SCN9A SCN10A	5.51e-05	146	151	7	CID000002083
Drug	17beta-estradiol glucuronide	ABCC3 ABCC4 ABCB5 ABCB1	5.79e-05	32	151	4	CID000066424
Drug	NSC93767	SCN3A SCN4A SCN9A SCN10A	5.79e-05	32	151	4	CID000005658
Drug	magnesium	KRAS GPLD1 CPAMD8 ABCB5 PSMA6 LAMA1 LAMB2 CCT4 ADGRV1 PFKL GTPBP10 RYR3 ABCB1 BPNT1 TRNT1 RAB4B HRAS PKLR ALDH2 HSD17B8 OPLAH PMM1	6.41e-05	1325	151	22	CID000000888
Drug	beryllium fluoride	ABCC4 UAP1 ABCB5 ABCB1 HRAS WDFY3	6.49e-05	103	151	6	CID000024589
Drug	trimetrexate	ABCC3 ABCB5 GART ABCB1	6.55e-05	33	151	4	CID000005582
Drug	saxitoxin	SCN2A SCN3A SCN4A SCN9A SCN10A	7.20e-05	65	151	5	CID000037165
Drug	AC1L8YYB	ABCC3 ABCC4 ABCB5 ABCB1	7.38e-05	34	151	4	CID000435167
Drug	Topo	ABCC3 ABCC4 ABCB5 ARHGEF12 ABCB1 TNKS2 GAA	7.41e-05	153	151	7	CID000065577
Drug	mexiletine	SCN3A SCN4A SCN5A SCN9A SCN10A	7.75e-05	66	151	5	CID000004178
Drug	disopyramide	SCN3A SCN4A SCN5A SCN9A SCN10A	7.75e-05	66	151	5	CID000003114
Drug	resiniferatoxin	ABCB1 SCN3A SCN4A SCN9A SCN10A	7.75e-05	66	151	5	CID000104826
Drug	hepta-3	ABCB5 PAF1 ABCB1	7.79e-05	13	151	3	CID000150893
Drug	harmol sulfate	ABCC3 ABCC4 ABCB1	7.79e-05	13	151	3	CID005488302
Drug	thioinosine	ABCC3 ABCC4 ABCB5 ABCB1	8.29e-05	35	151	4	CID000676166
Drug	dibucaine	SCN3A SCN4A SCN5A SCN9A SCN10A	8.94e-05	68	151	5	CID000003025
Drug	Ursodeoxycholic Acid	KRAS ABCC3 ABCC4 RPS28 ABCB1 HRAS PKLR EP300 OPLAH	9.78e-05	276	151	9	ctd:D014580
Drug	AC1LCF1F	ABCC3 ABCC4 ABCB5 SIL1 ABCB1 POSTN TGM7	1.02e-04	161	151	7	CID000627275
Drug	polyribosylribitol phosphate	ABCB5 GART PFKL ABCB1 UCKL1 PKLR	1.03e-04	112	151	6	CID000002219
Drug	benzbromarone	ABCC3 ABCC4 ABCB5 ABCB1	1.04e-04	37	151	4	CID000002333
Drug	guanine	KRAS GPLD1 NRAS GNE PSMA6 GART ARHGEF12 XRCC1 GTPBP10 ARFRP1 THRB ARHGEF10 MTIF2 HRAS HERC1 IQGAP3 GAA	1.05e-04	902	151	17	CID000000764
Drug	lipofectin	KRAS GNE DHRS11 ABCB1 SCN10A DMD	1.09e-04	113	151	6	CID006437083
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.48e-17	10	148	8	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.48e-17	10	148	8	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.61e-16	12	148	8	DOID:0060170 (implicated_via_orthology)
Disease	Follicular thyroid carcinoma	KRAS NRAS THRB HRAS	3.03e-09	5	148	4	C0206682
Disease	Colorectal Neoplasms	KRAS ABCC3 CPAMD8 ABCC4 NRAS ABCB5 LAMA1 ABCB1 POSTN ABCB10 ALDH2 EP300	1.74e-08	277	148	12	C0009404
Disease	Generalized Epilepsy with Febrile Seizures Plus	ADGRV1 SCN1A SCN2A SCN9A	7.51e-08	9	148	4	C3502809
Disease	Verrucous epidermal nevus	KRAS NRAS HRAS	1.24e-07	3	148	3	C0362030
Disease	Nevus Sebaceus of Jadassohn	KRAS NRAS HRAS	1.24e-07	3	148	3	C4552097
Disease	Organoid Nevus Phakomatosis	KRAS NRAS HRAS	1.24e-07	3	148	3	C0265329
Disease	Linear nevus sebaceous syndrome	KRAS NRAS HRAS	1.24e-07	3	148	3	cv:C4552097
Disease	Nevus sebaceous	KRAS NRAS HRAS	1.24e-07	3	148	3	C3854181
Disease	Inflammatory linear verrucous epidermal nevus	KRAS NRAS HRAS	1.24e-07	3	148	3	C0473574
Disease	SCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME	KRAS NRAS HRAS	1.24e-07	3	148	3	163200
Disease	linear nevus sebaceous syndrome (is_implicated_in)	KRAS NRAS HRAS	1.24e-07	3	148	3	DOID:0111530 (is_implicated_in)
Disease	Noonan syndrome 3 (implicated_via_orthology)	KRAS NRAS HRAS	1.24e-07	3	148	3	DOID:0060581 (implicated_via_orthology)
Disease	Linear Verrucous Epidermal Nevus	KRAS NRAS HRAS	1.24e-07	3	148	3	C3179502
Disease	cervical cancer (implicated_via_orthology)	KRAS NRAS HRAS	1.24e-07	3	148	3	DOID:4362 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	ABCB1 SCN1A SCN2A SCN3A SCN4A SCN5A SCN8A SCN9A SCN10A	1.46e-07	163	148	9	DOID:1826 (implicated_via_orthology)
Disease	Colorectal Carcinoma	KRAS ABCC3 CPAMD8 ABCC4 NRAS ABCB5 LAMA1 XRCC1 DSCAML1 ABCB1 POSTN ABCB10 B4GALNT2 ALDH2 DMD EP300	5.29e-07	702	148	16	C0009402
Disease	NEVUS, EPIDERMAL (disorder)	KRAS NRAS HRAS	1.23e-06	5	148	3	C0334082
Disease	Febrile seizure (within the age range of 3 months to 6 years)	SCN1A SCN2A HERC1 ANO3	1.76e-06	18	148	4	HP_0002373
Disease	leukemia (implicated_via_orthology)	KRAS NRAS ASH1L HRAS	2.22e-06	19	148	4	DOID:1240 (implicated_via_orthology)
Disease	Hemimegalencephaly	KRAS NRAS HRAS	2.45e-06	6	148	3	C0431391
Disease	seminoma (is_implicated_in)	KRAS XRCC1 HRAS	2.45e-06	6	148	3	DOID:4440 (is_implicated_in)
Disease	Neuroblastoma	KRAS NRAS ABCB1 ARID1B HRAS	3.84e-06	47	148	5	C0027819
Disease	anxiety disorder (implicated_via_orthology)	SCN1A SCN2A SCN3A SCN9A	4.14e-06	22	148	4	DOID:2030 (implicated_via_orthology)
Disease	Seizure, Febrile, Simple	SCN1A SCN2A ANO3	4.26e-06	7	148	3	C0149886
Disease	Seizure, Febrile, Complex	SCN1A SCN2A ANO3	4.26e-06	7	148	3	C0751057
Disease	Ventricular Dysfunction	ALDH2 DMD GAA	6.80e-06	8	148	3	C0242973
Disease	Neurodevelopmental Disorders	ASH1L ARID1B SCN1A SCN2A SCN8A WDFY3	7.66e-06	93	148	6	C1535926
Disease	Febrile Convulsions	SCN1A SCN2A ANO3	1.02e-05	9	148	3	C0009952
Disease	cystic fibrosis (implicated_via_orthology)	ABCC4 ABCB5 ABCB1	1.02e-05	9	148	3	DOID:1485 (implicated_via_orthology)
Disease	RASopathy (implicated_via_orthology)	KRAS NRAS HRAS	1.02e-05	9	148	3	DOID:0080690 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	ASH1L DSCAML1 ARID1B ARHGEF10 SCN1A SCN2A WDFY3	1.22e-05	152	148	7	DOID:0060041 (implicated_via_orthology)
Disease	Epilepsy	ABCB1 ARID1B SCN1A SCN2A SCN8A SCN9A	1.90e-05	109	148	6	C0014544
Disease	Noonan Syndrome 1	KRAS NRAS HRAS	1.98e-05	11	148	3	C4551602
Disease	Turner Syndrome, Male	KRAS NRAS HRAS	1.98e-05	11	148	3	C0041409
Disease	Female Pseudo-Turner Syndrome	KRAS NRAS HRAS	1.98e-05	11	148	3	C1527404
Disease	kidney cancer (implicated_via_orthology)	KRAS NRAS HRAS	1.98e-05	11	148	3	DOID:263 (implicated_via_orthology)
Disease	RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER	KRAS NRAS	2.50e-05	2	148	2	614470
Disease	Usher syndrome, type 2C	PDZD7 ADGRV1	2.50e-05	2	148	2	C2931213
Disease	Autoimmune lymphoproliferative syndrome type 4	KRAS NRAS	2.50e-05	2	148	2	cv:C2674723
Disease	autoimmune lymphoproliferative syndrome type 4 (is_implicated_in)	KRAS NRAS	2.50e-05	2	148	2	DOID:0110117 (is_implicated_in)
Disease	USHER SYNDROME, TYPE IIC	PDZD7 ADGRV1	2.50e-05	2	148	2	605472
Disease	MELANOCYTIC NEVUS SYNDROME, CONGENITAL	NRAS HRAS	2.50e-05	2	148	2	137550
Disease	Early Infantile Epileptic Encephalopathy 6	SCN1A SCN9A	2.50e-05	2	148	2	C4551549
Disease	Melanocytic nevus	NRAS HRAS	2.50e-05	2	148	2	cv:C0027962
Disease	RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER	KRAS NRAS	2.50e-05	2	148	2	C2674723
Disease	Usher syndrome type 2C	PDZD7 ADGRV1	2.50e-05	2	148	2	cv:C2931213
Disease	large congenital melanocytic nevus (is_implicated_in)	NRAS HRAS	2.50e-05	2	148	2	DOID:0111359 (is_implicated_in)
Disease	Usher syndrome type 2C (is_implicated_in)	PDZD7 ADGRV1	2.50e-05	2	148	2	DOID:0110839 (is_implicated_in)
Disease	Large congenital melanocytic nevus	NRAS HRAS	2.50e-05	2	148	2	cv:C1842036
Disease	Infantile Severe Myoclonic Epilepsy	SCN1A SCN2A SCN9A	3.41e-05	13	148	3	C0751122
Disease	hepatocellular carcinoma (is_implicated_in)	KMT2B NRAS XRCC1 RYR3 ABCB1 HRAS ALDH2	3.76e-05	181	148	7	DOID:684 (is_implicated_in)
Disease	T wave morphology measurement	PREP SCN5A SCN10A	4.32e-05	14	148	3	EFO_0008398
Disease	Cardiomyopathies	KRAS NRAS SCN5A HRAS DMD GAA	5.14e-05	130	148	6	C0878544
Disease	Neoplasm of uncertain or unknown behavior of breast	KRAS ARID1B HRAS EP300	5.33e-05	41	148	4	C0496956
Disease	Breast adenocarcinoma	KRAS ARID1B HRAS EP300	5.33e-05	41	148	4	C0858252
Disease	MMR-related febrile seizures	SCN1A SCN2A ANO3	5.38e-05	15	148	3	EFO_0006519
Disease	RASopathy	KRAS NRAS HRAS	5.38e-05	15	148	3	cv:C5555857
Disease	Epilepsy, Cryptogenic	ABCB1 ARID1B SCN1A SCN2A SCN8A	5.93e-05	82	148	5	C0086237
Disease	Awakening Epilepsy	ABCB1 ARID1B SCN1A SCN2A SCN8A	5.93e-05	82	148	5	C0751111
Disease	Aura	ABCB1 ARID1B SCN1A SCN2A SCN8A	5.93e-05	82	148	5	C0236018
Disease	high grade glioma (implicated_via_orthology)	KRAS NRAS ABCB1 HRAS	7.06e-05	44	148	4	DOID:3070 (implicated_via_orthology)
Disease	B Virus Infection	SCN8A SCN9A	7.47e-05	3	148	2	C0037140
Disease	Benign familial infantile epilepsy	SCN2A SCN8A	7.47e-05	3	148	2	cv:C5575231
Disease	Postherpetic neuralgia	SCN8A SCN9A	7.47e-05	3	148	2	C0032768
Disease	Herpesviridae Infections	SCN8A SCN9A	7.47e-05	3	148	2	C0019372
Disease	Primary Erythermalgia	SCN9A SCN10A	7.47e-05	3	148	2	C0014805
Disease	GIANT PIGMENTED HAIRY NEVUS	NRAS HRAS	7.47e-05	3	148	2	C1842036
Disease	PAROXYSMAL EXTREME PAIN DISORDER	SCN9A SCN10A	7.47e-05	3	148	2	C1833661
Disease	Noonan-Like Syndrome With Loose Anagen Hair	KRAS NRAS HRAS	1.13e-04	19	148	3	C3501846
Disease	Noonan syndrome-like disorder with loose anagen hair	KRAS NRAS HRAS	1.13e-04	19	148	3	C1843181
Disease	Cardio-facio-cutaneous syndrome	KRAS NRAS HRAS	1.13e-04	19	148	3	C1275081
Disease	Costello syndrome (disorder)	KRAS NRAS HRAS	1.13e-04	19	148	3	C0587248
Disease	Paroxysmal atrial fibrillation	THRB SCN5A SCN10A FGF5 HERC1 COG5	1.41e-04	156	148	6	C0235480
Disease	familial atrial fibrillation	THRB SCN5A SCN10A FGF5 HERC1 COG5	1.41e-04	156	148	6	C3468561
Disease	Persistent atrial fibrillation	THRB SCN5A SCN10A FGF5 HERC1 COG5	1.41e-04	156	148	6	C2585653
Disease	Brugada ECG Pattern	SCN5A SCN10A	1.49e-04	4	148	2	C1721096
Disease	NEVUS, EPIDERMAL	NRAS HRAS	1.49e-04	4	148	2	162900
Disease	Malignant neoplasm of penis	KRAS HRAS	1.49e-04	4	148	2	C0153601
Disease	Penile Neoplasms	KRAS HRAS	1.49e-04	4	148	2	C0030849
Disease	Nevus, Keratinocytic, Nonepidermolytic	NRAS HRAS	1.49e-04	4	148	2	C4011754
Disease	BLADDER CANCER	KRAS HRAS	1.49e-04	4	148	2	109800
Disease	Epidermal nevus	NRAS HRAS	1.49e-04	4	148	2	cv:C0334082
Disease	Malignant tumor of urinary bladder	KRAS HRAS	1.49e-04	4	148	2	cv:C0005684
Disease	Thyroid cancer, nonmedullary, 2	NRAS HRAS	1.49e-04	4	148	2	cv:C4225426
Disease	Malignant tumor of cervix	KRAS HRAS	1.49e-04	4	148	2	C0007847
Disease	epidermal nevus (is_implicated_in)	NRAS HRAS	1.49e-04	4	148	2	DOID:0111162 (is_implicated_in)
Disease	THYROID CANCER, NONMEDULLARY, 2	NRAS HRAS	1.49e-04	4	148	2	188470
Disease	chronic myeloid leukemia (is_implicated_in)	ABL1 XRCC1 ABCB1	1.54e-04	21	148	3	DOID:8552 (is_implicated_in)
Disease	Atrial Fibrillation	THRB SCN5A SCN10A FGF5 HERC1 COG5	1.62e-04	160	148	6	C0004238
Disease	acute lymphoblastic leukemia (is_implicated_in)	KRAS NRAS XRCC1 ABCB1	1.70e-04	55	148	4	DOID:9952 (is_implicated_in)
Disease	LEOPARD Syndrome	KRAS NRAS HRAS	1.78e-04	22	148	3	C0175704
Disease	Noonan Syndrome	KRAS NRAS HRAS	2.32e-04	24	148	3	C0028326
Disease	THYROID CANCER, NONMEDULLARY, 2	NRAS HRAS	2.47e-04	5	148	2	C4225426
Disease	Malignant neoplasm of thyroid	KRAS NRAS	2.47e-04	5	148	2	C0007115
Disease	Cetuximab response	KRAS NRAS	2.47e-04	5	148	2	cv:CN077967
Disease	Duchenne and Becker Muscular Dystrophy	POSTN DMD	2.47e-04	5	148	2	C3542021
Disease	Cervix carcinoma	KRAS HRAS	2.47e-04	5	148	2	C0302592

Protein segments in the cluster

Peptide	Gene	Start	Entry
GQQSGLKILGQLTTD	BHLHB9	421	Q6PI77
GASGLGLQIQTKTVL	EP300	266	Q09472
GTVQGQLQGPISKVR	ACYP1	46	P07311
NVIGQITQLIGNLKG	ARHGEF10	761	O15013
RGIIGGKSQRVNGLT	ASH1L	2281	Q9NR48
VVQGRGQKQLIISTS	B4GALNT2	246	Q8NHY0
QVSGLQLLASVGKTG	B4GALNT3	201	Q6L9W6
GLNGSGKSTVVQLLQ	ABCB5	421	Q2M3G0
LNQLLKGVTIASGGV	MACROH2A2	91	Q9P0M6
LNQLLKGVTIASGGV	MACROH2A1	91	O75367
VILLNGTGGAKVGNR	ADGRV1	976	Q8WXG9
KATIQGVLRAGSQLR	AP2A1	556	O95782
FVGAGIIQTKALQVG	AP2A1	926	O95782
GVLLSGGQKQRIAIA	ABCB10	631	Q9NRK6
ARAIAVQKGSIGNLI	ARID1B	2216	Q8NFD5
VGNILQLGSKLIGTG	DMD	396	P11532
GDRVVIAGQKVGTLR	CLIP4	286	Q8N3C7
LRVGGAGNKIIQLIE	BPNT1	216	O95861
AGVQTGDRIIKVNGT	ARHGEF12	106	Q9NZN5
GISKVGIRKLINNGS	ANO3	321	Q9BYT9
VKVQGGGGSLVITQI	IGDCC4	381	Q8TDY8
AGGVGKSALTIQLIQ	HRAS	11	P01112
AGGVGKSALTIQLIQ	KRAS	11	P01116
AGGVGKSALTIQLIQ	NRAS	11	P01111
GSRVVNVGGKTVKLQ	RAB4B	46	P61018
EKGINLSGGQRQRVS	ABCC3	746	O15438
KGAIGSRLAVITQNI	ABCB1	826	P08183
VLKRGLQQITGHGGL	NDUFA12	6	Q9UI09
QALIVGVKKGGTRAV	HS3ST2	116	Q9Y278
GSNKRIGQVVNTGVL	KPNA7	271	A9QM74
VFNGKRVLVVGLGNS	FMO3	181	P31513
TSQVLGLGINGKVLQ	MAPKAPK2	66	P49137
GQLNIGISNIKAIGV	GK3P	76	Q14409
KGRGLVTTAIIQRGT	MTIF2	366	P46199
IQRGTLRKGSVLVAG	MTIF2	376	P46199
QILGGGQVATLSKLL	MTMR12	651	Q9C0I1
LVRTRGGNTGVVKVQ	KIAA2026	1281	Q5HYC2
LVTGLQGKNVRQISA	HERC1	4336	Q15751
KIQLQGGITSITLRG	CFAP52	286	Q8N1V2
KGQIQEIVLVGGSTR	HSPA2	331	P54652
GTVGGRLATISVNKQ	PCYOX1L	61	Q8NBM8
GIKVGDQVLAANGVR	PDZD7	251	Q9H5P4
QRGDRLIAIGGVKIT	PDZD8	411	Q8NEN9
IIQLGGTIIGSARCK	PFKL	76	P17858
SGIKGLQGVVRKTVN	EFR3B	166	Q9Y2G0
GLGNQVEVLKTRGIN	DIP2B	1261	Q9P265
VTLGGVLRQQLVVSK	KLHL9	301	Q9P2J3
EKLGIVQGIVGARNT	LAMB2	1236	P55268
LVTQVENGGVLGSRK	PKLR	236	P30613
CILIRGVGKSVLVGN	FBXO25	181	Q8TCJ0
GGLRQVLQGLLSSKV	KMT2B	1411	Q9UMN6
GEGVTLQGNITLLKG	SLC7A5P2	41	Q9GIP4
QSSSTLKGVLVRNGG	ITPRID2	96	P28290
VVALRGGLNTILKNV	RICTOR	201	Q6R327
GRGQSALQEILGKVI	IQGAP3	1046	Q86VI3
RSIGNKNTILLGLGF	MFSD14A	306	Q96MC6
VIVTGANTGIGKQTA	RDH13	41	Q8NBN7
QALRQLQTLKGGLGV	PKD1L2	1781	Q7Z442
IGAGSKTLGARQRLQ	POM121B	811	A6NF01
KIGITLSNAIVNAGL	HFM1	936	A2PYH4
RGTTLSGGQKARVNL	ABCC4	531	O15439
KRLTINGGSNGGLLV	PREP	546	P48147
VASKGRGGLLEVNLQ	PCDHA4	66	Q9UN74
VSQGIVGIRGVFSNK	FGF5	126	P12034
FQRKTLVLIGAQGVG	PALS2	336	Q9NZW5
RAKAGVQSGTNALLV	PAF1	336	Q8N7H5
SKRLQGQLQGGSREI	COG5	186	Q9UP83
TVGLNIGTVDVGKAR	ARFRP1	56	Q13795
TRVIEFTTVGIGGKN	HYDIN	3981	Q4G0P3
ILVAQGGLGGKLLTN	GTPBP10	116	A4D1E9
GTVLNNKLFITGGIT	KLHL15	421	Q96M94
LVNKGILVQTRGTGA	H1-6	91	P22492
VKLNCRILGVGISTG	GNE	461	Q9Y223
KQFIRSVGEGTINGL	CARD17	11	Q5XLA6
RKDGQVIISGSGVTI	DSCAML1	631	Q8TD84
LTQKGSGNAVVIVVG	DGAT2L6	171	Q6ZPD8
IINISSIVGKVGNVG	HSD17B8	151	Q92506
RNVVQTGKAVGQSVG	AVL9	601	Q8NBF6
LAVGRVLNKDIQGGI	CPAMD8	1251	Q8IZJ3
QGGSIVNVGSIVGLK	CBR4	126	Q8N4T8
GKQGVRGAVSTLLQA	ABL1	511	P00519
GAGLQLQKVTVLGVA	GAA	896	P10253
ILKNLTTTGRQFGGI	MDH1B	361	Q5I0G3
GAAAVVLGKQVLVVG	KLHDC8B	71	Q8IXV7
GLSKGIVQGVLATIN	GLB1L2	236	Q8IW92
SVNGEVLTGAIKRGV	CCDC168	1906	Q8NDH2
AVARALVQQGLKVVG	DHRS11	26	Q6UWP2
AVIGRGGSKIKNIQS	DDX43	81	Q9NXZ2
GGGSGIVQNTKALIL	CENPE	2531	Q02224
VGVLGSKLGLQVVEL	DDAH1	51	O94760
KGVVTAGQVRGNSTV	NUP210L	511	Q5VU65
AGSIIGKGGQTIVQL	NOVA1	61	P51513
TVVFQGAAGIGKTIL	NLRP3	221	Q96P20
VGLIIGRGGEQINKI	KHSRP	156	Q92945
GFIIKTGLGNQSTRV	FREM3	1711	P0C091
LVGAVNVAKGTVQTG	PLIN4	591	Q96Q06
TGLTGAVNLAKGTVQ	PLIN4	886	Q96Q06
LNGSQIGLLRKAGIQ	PLD6	131	Q8N2A8
ATQAVLLGIGVGNAK	RUSF1	111	Q96GQ5
TNQTKGLLRAAAVGI	SNX13	431	Q9Y5W8
VGISSGKEIGALLQQ	TRNT1	396	Q96Q11
KIIGNSVGALGNLTL	SCN4A	691	P35499
VNGLTLGGQKCSVIR	PFN1	61	P07737
SILAVGVGNVRVKFG	TMEM132C	786	Q8N3T6
ALQGKLGGVQRVLST	NHS	166	Q6T4R5
RKNGRTVNLGGKTSV	OPLAH	1221	O14841
IIKGNGLTLSTQAEG	LAMA1	611	P25391
QRGQTVGSVGKVGQV	KCNV2	361	Q8TDN2
LIGQGIIVKDARLNG	TENT5D	51	Q8NEK8
GTKILQSIQRGIQVT	RNF128	176	Q8TEB7
NTLIKIIGNSVGALG	SCN5A	826	Q14524
IKIIGNSVGALGNLT	SCN9A	856	Q15858
GGLQVLRTLVQEKGT	SIL1	311	Q9H173
IIVGNGGVLANKSLG	ST3GAL3	161	Q11203
GILVSLSTGGRKQNL	SLC5A8	536	Q8N695
AGINVRKGGISNILE	CCT4	491	P50991
IITLTVGTNGGLKVV	TENM2	1656	Q9NT68
VGTNGGLKVVSTQNL	TENM2	1661	Q9NT68
LIKIIGNSVGALGNL	SCN3A	871	Q9NY46
SQAKVQRILRLISGG	SGMS2	196	Q8NHU3
KLRSRVQIGVVGGSD	PMM1	41	Q92871
GQVLKNFSGRIEGIQ	SPATA9	11	Q9BWV2
KIIGNSVGALGNLTL	SCN1A	881	P35498
GGLQRSLKIRIQVAG	BRMS1	106	Q9HCU9
GKVIILTAAAQGIGQ	BDH2	6	Q9BUT1
IGRVIQVAAGSSNLK	ALDH2	266	P05091
ATAGIIGVNRKGQVL	CLTC	311	Q00610
AINQGGLTSVAVRGK	PSMA6	31	P60900
KVVGDLLSGTILVGQ	RNF213	1091	Q63HN8
LTNKIGTVLGFNVGR	WDFY3	1721	Q8IZQ1
QGGVAQLVIKGARDS	SECTM1	96	Q8WVN6
IGGTLQGFISDVLQK	SLC37A3	341	Q8NCC5
AAVTIGFGQIKNLLG	SLC26A11	161	Q86WA9
VETLKLGIAILNGGN	RYR3	3646	Q15413
LIKIIGNSVGALGNL	SCN10A	776	Q9Y5Y9
VVGQSGLGKSTLVNT	SEPTIN3	66	Q9UH03
IRGGLSNLGIKSIVT	TRAPPC6B	126	Q86SZ2
VTRGQLKNGGLGVVS	THRB	336	P10828
TAKGGVGKLVTLRNV	SUGP2	236	Q8IX01
GALKGDGILIVVNTV	SLC50A1	61	Q9BRV3
IKIIGNSVGALGNLT	SCN2A	871	Q99250
VKSGISFLIQTGVGI	VN1R1	46	Q9GZP7
AKNQVVIAAGRSSLG	GPLD1	811	P80108
EKITQRGGLSNVGRA	VIT	361	Q6UXI7
VETIGLLQSTSGKQG	ZNF281	511	Q9Y2X9
KIIGNSVGALGNLTL	SCN8A	866	Q9UQD0
NGKVVTHGGRVLAVT	GART	376	P22102
LIKGVERLISGQQGL	TNKS2	926	Q9H2K2
NKVAVLLLAGGQGTR	UAP1	101	Q16222
GQLQVGLGISNLSKS	nan	116	Q96MT0
GRTASLIIKVQQLNG	VPS13B	2706	Q7Z7G8
LGKILQGVVVVLSGF	XRCC1	316	P18887
GKQITGVSILRAGET	UCKL1	391	Q9NWZ5
VSVQLGDGTRLKGTV	ZNF687	386	Q8N1G0
GQILETIGGKQLRVF	POSTN	446	Q15063
INGQIAKDLGTLVAG	TGM7	651	Q96PF1
VRVVKQEAGGLGISI	SNTB2	116	Q13425
LARVTKVLGRTGSQG	RPS28	11	P62857
QLVLGAGALQVVGLK	VPS54	786	Q9P1Q0
LKGRRTLVGGQQVTL	ZAN	1226	Q9Y493
LDGGSGVRALKVIQQ	VPS13D	3356	Q5THJ4