Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	5-methylcytosine dioxygenase activity	TET2 TET1	3.03e-05	3	64	2	GO:0070579
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	6.04e-05	4	64	2	GO:0001602
GeneOntologyMolecularFunction	protein kinase binding	TAOK2 FOXO3 PITPNM2 MYH6 FZD5 KCNQ1 TAOK1 TRIM34 GRM5 PRLR SLC12A5	9.32e-05	873	64	11	GO:0019901
GeneOntologyMolecularFunction	kinase binding	TAOK2 FOXO3 PITPNM2 MYH6 FZD5 KCNQ1 TAOK1 TRIM34 GRM5 PRLR SLC12A5	2.33e-04	969	64	11	GO:0019900
GeneOntologyMolecularFunction	microfilament motor activity	MYO1G MYH6 MYH7B	2.45e-04	38	64	3	GO:0000146
GeneOntologyMolecularFunction	aspartic endopeptidase activity, intramembrane cleaving	SPPL2A PSEN2	2.80e-04	8	64	2	GO:0042500
GeneOntologyMolecularFunction	neurotransmitter receptor activity	HTR1E GRIK3 GRM5 CHRM1	2.99e-04	100	64	4	GO:0030594
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	TAS2R42 NPY4R2 HTR1E NPY4R FZD5 CCR9 GPR37L1 GRIK3 PTPRU GRM5 IL1RAP CHRM1 PRLR	3.05e-04	1353	64	13	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRIK3 GRM5	3.59e-04	9	64	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRIK3 GRM5	3.59e-04	9	64	2	GO:0001640
GeneOntologyMolecularFunction	G protein-coupled receptor activity	TAS2R42 NPY4R2 HTR1E NPY4R FZD5 CCR9 GPR37L1 GRIK3 GRM5 CHRM1	4.75e-04	884	64	10	GO:0004930
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	NPY4R2 NPY4R	5.46e-04	11	64	2	GO:0004983
GeneOntologyMolecularFunction	beta-catenin binding	FOXO3 MED12L PTPRU MED12	5.97e-04	120	64	4	GO:0008013
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	EMILIN3 EMILIN1	6.54e-04	12	64	2	GO:0030023
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	EMILIN3 EMILIN1	8.98e-04	14	64	2	GO:0097493
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GRIK3 GRM5 CHRM1	1.80e-03	75	64	3	GO:0098960
GeneOntologyMolecularFunction	tau-protein kinase activity	TAOK2 TAOK1	2.24e-03	22	64	2	GO:0050321
GeneOntologyMolecularFunction	G protein-coupled serotonin receptor activity	HTR1E CHRM1	2.24e-03	22	64	2	GO:0004993
GeneOntologyMolecularFunction	histone deacetylase activity	MIER3 MIER1	2.67e-03	24	64	2	GO:0004407
GeneOntologyMolecularFunction	protein lysine deacetylase activity	MIER3 MIER1	2.89e-03	25	64	2	GO:0033558
GeneOntologyMolecularFunction	glutamate receptor activity	GRIK3 GRM5	3.37e-03	27	64	2	GO:0008066
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	HTR1E GPR37L1 GRIK3 GRM5 CHRM1	6.51e-06	86	63	5	GO:0007193
GeneOntologyBiologicalProcess	positive regulation of gene expression via chromosomal CpG island demethylation	TET2 TET1 NIBAN2	1.20e-05	15	63	3	GO:0044029
Domain	EMI	EMID1 EMILIN3 EMILIN1	4.32e-06	10	63	3	PF07546
Domain	Tet_JBP	TET2 TET1	1.12e-05	2	63	2	PF12851
Domain	2OGFeDO_noxygenase_dom	TET2 TET1	1.12e-05	2	63	2	IPR024779
Domain	Mediator_Med12	MED12L MED12	1.12e-05	2	63	2	IPR019035
Domain	NPY4_rcpt	NPY4R2 NPY4R	1.12e-05	2	63	2	IPR001933
Domain	Med12	MED12L MED12	1.12e-05	2	63	2	PF09497
Domain	Mediator_Med12_LCEWAV	MED12L MED12	1.12e-05	2	63	2	IPR021990
Domain	Mediator_Med12_catenin-bd	MED12L MED12	1.12e-05	2	63	2	IPR021989
Domain	Med12-PQL	MED12L MED12	1.12e-05	2	63	2	PF12144
Domain	Med12-LCEWAV	MED12L MED12	1.12e-05	2	63	2	PF12145
Domain	Med12	MED12L MED12	1.12e-05	2	63	2	SM01281
Domain	Tet_JBP	TET2 TET1	1.12e-05	2	63	2	SM01333
Domain	EMI_domain	EMID1 EMILIN3 EMILIN1	1.99e-05	16	63	3	IPR011489
Domain	EMI	EMID1 EMILIN3 EMILIN1	2.40e-05	17	63	3	PS51041
Domain	PSN	SPPL2A PSEN2	2.33e-04	7	63	2	SM00730
Domain	Preselin/SPP	SPPL2A PSEN2	2.33e-04	7	63	2	IPR006639
Domain	Myosin_head_motor_dom	MYO1G MYH6 MYH7B	2.84e-04	38	63	3	IPR001609
Domain	MYOSIN_MOTOR	MYO1G MYH6 MYH7B	2.84e-04	38	63	3	PS51456
Domain	Myosin_head	MYO1G MYH6 MYH7B	2.84e-04	38	63	3	PF00063
Domain	MYSc	MYO1G MYH6 MYH7B	2.84e-04	38	63	3	SM00242
Domain	NPY_rcpt	NPY4R2 NPY4R	3.97e-04	9	63	2	IPR000611
Domain	ELM2	MIER3 MIER1	8.53e-04	13	63	2	PF01448
Domain	ELM2	MIER3 MIER1	8.53e-04	13	63	2	PS51156
Domain	ELM2_dom	MIER3 MIER1	8.53e-04	13	63	2	IPR000949
Domain	ELM2	MIER3 MIER1	8.53e-04	13	63	2	SM01189
Domain	Myosin_N	MYH6 MYH7B	1.14e-03	15	63	2	PF02736
Domain	Myosin_N	MYH6 MYH7B	1.14e-03	15	63	2	IPR004009
Domain	Myosin_tail_1	MYH6 MYH7B	1.65e-03	18	63	2	PF01576
Domain	Myosin_tail	MYH6 MYH7B	1.65e-03	18	63	2	IPR002928
Domain	Myosin-like_IQ_dom	MYH6 MYH7B	1.85e-03	19	63	2	IPR027401
Domain	-	MYH6 MYH7B	1.85e-03	19	63	2	4.10.270.10
Domain	SANT_dom	MIER3 MIER1	3.45e-03	26	63	2	IPR017884
Domain	SANT	MIER3 MIER1	4.00e-03	28	63	2	PS51293
Domain	Myb_DNA-binding	MIER3 MIER1	6.20e-03	35	63	2	PF00249
Domain	ANF_lig-bd_rcpt	GRIK3 GRM5	6.91e-03	37	63	2	IPR001828
Domain	ANF_receptor	GRIK3 GRM5	6.91e-03	37	63	2	PF01094
Domain	GPCR_Rhodpsn_7TM	TAS2R42 NPY4R2 HTR1E NPY4R CCR9 GPR37L1 CHRM1	7.19e-03	670	63	7	IPR017452
Domain	Peripla_BP_I	GRIK3 GRM5	7.66e-03	39	63	2	IPR028082
Domain	G_PROTEIN_RECEP_F1_2	TAS2R42 NPY4R2 HTR1E NPY4R CCR9 GPR37L1 CHRM1	8.45e-03	691	63	7	PS50262
Domain	GPCR_Rhodpsn	TAS2R42 NPY4R2 HTR1E NPY4R CCR9 GPR37L1 CHRM1	8.51e-03	692	63	7	IPR000276
Pubmed	Developmental expression and biochemical characterization of Emu family members.	EMID1 EMILIN3 EMILIN1	2.27e-07	7	66	3	12221002
Pubmed	miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta.	GRB10 KCNQ1 EMCN	1.84e-06	13	66	3	30771304
Pubmed	Distributive Processing by the Iron(II)/α-Ketoglutarate-Dependent Catalytic Domains of the TET Enzymes Is Consistent with Epigenetic Roles for Oxidized 5-Methylcytosine Bases.	TET2 TET1	3.55e-06	2	66	2	27362828
Pubmed	Structural insight into substrate preference for TET-mediated oxidation.	TET2 TET1	3.55e-06	2	66	2	26524525
Pubmed	Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.	TET2 TET1	3.55e-06	2	66	2	30045709
Pubmed	Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells.	TET2 TET1	3.55e-06	2	66	2	23415914
Pubmed	Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice.	TET2 TET1	3.55e-06	2	66	2	30540950
Pubmed	Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation.	TET2 TET1	3.55e-06	2	66	2	32114381
Pubmed	Early Expression of Tet1 and Tet2 in Mouse Zygotes Altered DNA Methylation Status and Affected Embryonic Development.	TET2 TET1	3.55e-06	2	66	2	35955629
Pubmed	Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism.	TET2 TET1	3.55e-06	2	66	2	24214992
Pubmed	Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.	TET2 TET1	3.55e-06	2	66	2	24474761
Pubmed	Ten-eleven translocation protein 1 modulates medulloblastoma progression.	TET2 TET1	3.55e-06	2	66	2	33926529
Pubmed	Coordination of engineered factors with TET1/2 promotes early-stage epigenetic modification during somatic cell reprogramming.	TET2 TET1	3.55e-06	2	66	2	24672749
Pubmed	Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis.	FOXO3 TET2	3.55e-06	2	66	2	28660881
Pubmed	A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands.	TET2 TET1	3.55e-06	2	66	2	27288448
Pubmed	Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination.	TET2 TET1	3.55e-06	2	66	2	30606231
Pubmed	Ten-eleven translocation 2 modulates allergic inflammation by 5-hydroxymethylcytosine remodeling of immunologic pathways.	TET2 TET1	3.55e-06	2	66	2	34165552
Pubmed	Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation.	TET2 TET1	3.55e-06	2	66	2	26598602
Pubmed	Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice.	TET2 TET1	3.55e-06	2	66	2	26586431
Pubmed	Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.	TAOK2 TAOK1	3.55e-06	2	66	2	28830982
Pubmed	Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns.	TET2 TET1	3.55e-06	2	66	2	35075236
Pubmed	TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.	TET2 CSMD1	3.55e-06	2	66	2	25695618
Pubmed	Tet-mediated imprinting erasure in H19 locus following reprogramming of spermatogonial stem cells to induced pluripotent stem cells.	TET2 TET1	3.55e-06	2	66	2	26328763
Pubmed	Ten-Eleven Translocation 1 and 2 Confer Overlapping Transcriptional Programs for the Proliferation of Cultured Adult Neural Stem Cells.	TET2 TET1	3.55e-06	2	66	2	27778125
Pubmed	TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells.	TET2 TET1	3.55e-06	2	66	2	27863519
Pubmed	Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.	TET2 TET1	3.55e-06	2	66	2	28783731
Pubmed	Novel Epigenetic Controlling of Hypoxia Pathway Related to Overexpression and Promoter Hypomethylation of TET1 and TET2 in RPE Cells.	TET2 TET1	3.55e-06	2	66	2	28252217
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TAOK2 PITPNM2 TET2 SETX TET1 MED12L SHISAL1 MIER1	7.20e-06	529	66	8	14621295
Pubmed	Expression of TET and 5-HmC in Trophoblast Villi of Women with Normal Pregnancy and with Early Pregnancy Loss.	TET2 TET1	1.06e-05	3	66	2	30074219
Pubmed	Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter.	TET2 TET1	1.06e-05	3	66	2	24194590
Pubmed	PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation.	TET2 TET1	1.06e-05	3	66	2	26325469
Pubmed	TET proteins in malignant hematopoiesis.	TET2 TET1	1.06e-05	3	66	2	19923888
Pubmed	Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells.	TET2 TET1	1.06e-05	3	66	2	31433977
Pubmed	Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.	TAOK2 TAOK1	1.06e-05	3	66	2	9786855
Pubmed	Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency.	TET2 TET1	1.06e-05	3	66	2	31844322
Pubmed	Selective targeting of TET catalytic domain promotes somatic cell reprogramming.	TET2 TET1	1.06e-05	3	66	2	32024762
Pubmed	Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs.	TET2 TET1	1.06e-05	3	66	2	27184841
Pubmed	Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.	TET2 TET1	1.06e-05	3	66	2	24838012
Pubmed	TAO kinases mediate activation of p38 in response to DNA damage.	TAOK2 TAOK1	1.06e-05	3	66	2	17396146
Pubmed	Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.	TET2 TET1	1.06e-05	3	66	2	21778364
Pubmed	Tet family proteins and 5-hydroxymethylcytosine in development and disease.	TET2 TET1	1.06e-05	3	66	2	22569552
Pubmed	Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins.	TET2 TET1	1.06e-05	3	66	2	26356709
Pubmed	Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.	TET2 TET1	1.06e-05	3	66	2	29662175
Pubmed	A novel epigenetic marker, Ten-eleven translocation family member 2 (TET2), is identified in the intractable epileptic brain and regulates ATP binding cassette subfamily B member 1 (ABCB1) in the blood-brain barrier.	TET2 TET1	1.06e-05	3	66	2	35235761
Pubmed	One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering.	TET2 TET1	1.06e-05	3	66	2	23992847
Pubmed	Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum.	GRM5 CHRM1	1.06e-05	3	66	2	17409230
Pubmed	Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.	TET2 TET1	1.06e-05	3	66	2	19372391
Pubmed	Inhibition of Tet1- and Tet2-mediated DNA demethylation promotes immunomodulation of periodontal ligament stem cells.	TET2 TET1	1.06e-05	3	66	2	31611558
Pubmed	The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.	TET2 TET1	1.06e-05	3	66	2	25915124
Pubmed	Mechanisms of TET protein-mediated DNA demethylation and its role in the regulation of mouse development.	TET2 TET1	1.06e-05	3	66	2	25608811
Pubmed	Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.	TET2 TET1	1.06e-05	3	66	2	19420352
Pubmed	Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.	TET2 TET1	1.06e-05	3	66	2	28218476
Pubmed	Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.	TET2 TET1	1.06e-05	3	66	2	23548903
Pubmed	MYC deregulates TET1 and TET2 expression to control global DNA (hydroxy)methylation and gene expression to maintain a neoplastic phenotype in T-ALL.	TET2 TET1	1.06e-05	3	66	2	31266538
Pubmed	5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function.	TET2 TET1	1.06e-05	3	66	2	34919053
Pubmed	Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells.	TET2 TET1	1.06e-05	3	66	2	24958354
Pubmed	One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.	TET2 TET1	1.06e-05	3	66	2	23643243
Pubmed	Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation.	TET2 TET1	1.06e-05	3	66	2	34879277
Pubmed	Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development.	TET2 TET1	1.06e-05	3	66	2	23352810
Pubmed	Oxygen regulation of TET enzymes.	TET2 TET1	1.06e-05	3	66	2	33410283
Pubmed	Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.	TAOK2 TAOK1	1.06e-05	3	66	2	23585562
Pubmed	Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.	TET2 TET1	1.06e-05	3	66	2	21816367
Pubmed	Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.	TET2 TET1	1.06e-05	3	66	2	22445327
Pubmed	IGF2BP1 expression in human mesenchymal stem cells significantly affects their proliferation and is under the epigenetic control of TET1/2 demethylases.	TET2 TET1	1.06e-05	3	66	2	24915579
Pubmed	TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing.	TET2 TET1	1.06e-05	3	66	2	26711177
Pubmed	miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2.	TET2 TET1	1.06e-05	3	66	2	31941838
Pubmed	TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).	TET2 TET1	1.06e-05	3	66	2	12646957
Pubmed	Loss of Tet enzymes compromises proper differentiation of embryonic stem cells.	TET2 TET1	1.06e-05	3	66	2	24735881
Pubmed	PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells.	TET2 TET1	1.06e-05	3	66	2	24335252
Pubmed	Differential expression of ten-eleven translocation genes in endometrial cancers.	TET2 TET1	1.06e-05	3	66	2	28349832
Pubmed	Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States.	TET2 TET1	1.06e-05	3	66	2	27345836
Pubmed	Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion.	TET2 TET1	1.06e-05	3	66	2	23453809
Pubmed	Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.	TET2 TET1	1.06e-05	3	66	2	20639862
Pubmed	Ten-Eleven Translocation Genes are Downregulated in Endometriosis.	TET2 TET1	1.06e-05	3	66	2	26917261
Pubmed	Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.	NPY4R2 NPY4R	1.06e-05	3	66	2	8643460
Pubmed	Alternation of ten-eleven translocation 1, 2, and 3 expression in eutopic endometrium of women with endometriosis-associated infertility.	TET2 TET1	1.06e-05	3	66	2	30130982
Pubmed	Regulation of DNA methylation signatures on NF-κB and STAT3 pathway genes and TET activity in cigarette smoke extract-challenged cells/COPD exacerbation model in vitro.	TET2 TET1	1.06e-05	3	66	2	32342329
Pubmed	Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.	TET2 TET1	2.12e-05	4	66	2	35235365
Pubmed	[DNA hypomethylation in villi of patients with unexplained recurrent spontaneous abortion and its mechanism].	TET2 TET1	2.12e-05	4	66	2	31167695
Pubmed	Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.	TET2 TET1	2.12e-05	4	66	2	21321204
Pubmed	Paradoxical association of TET loss of function with genome-wide DNA hypomethylation.	TET2 TET1	2.12e-05	4	66	2	31371502
Pubmed	Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).	TET2 TET1	2.12e-05	4	66	2	24394411
Pubmed	Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins.	TET2 TET1	2.12e-05	4	66	2	23028748
Pubmed	Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules.	TET2 TET1	2.12e-05	4	66	2	30554962
Pubmed	Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.	TET2 TET1	2.12e-05	4	66	2	23352454
Pubmed	TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.	TET2 TET1	2.12e-05	4	66	2	32234487
Pubmed	TET1 Directs Chondrogenic Differentiation by Regulating SOX9 Dependent Activation of Col2a1 and Acan In Vitro.	TET2 TET1	2.12e-05	4	66	2	33134768
Pubmed	UVB induces cutaneous squamous cell carcinoma progression by de novo ID4 methylation via methylation regulating enzymes.	TET2 TET1	2.12e-05	4	66	2	32574963
Pubmed	TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks.	SPOP ZRANB1	2.12e-05	4	66	2	37002234
Pubmed	Receptor Species-dependent Desensitization Controls KCNQ1/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.	KCNQ1 CHRM1	2.12e-05	4	66	2	27834678
Pubmed	Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).	TET2 TET1	2.12e-05	4	66	2	25568311
Pubmed	Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect.	FOXO3 PRLR	2.12e-05	4	66	2	17975019
Pubmed	Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.	TET2 TET1	2.12e-05	4	66	2	21295276
Pubmed	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.	NPY4R2 NPY4R	2.12e-05	4	66	2	7592911
Pubmed	Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.	TAOK2 TAOK1	2.12e-05	4	66	2	10497253
Pubmed	EMILIN-3, peculiar member of elastin microfibril interface-located protein (EMILIN) family, has distinct expression pattern, forms oligomeric assemblies, and serves as transforming growth factor β (TGF-β) antagonist.	EMILIN3 EMILIN1	2.12e-05	4	66	2	22334695
Pubmed	TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice.	TET2 TET1	2.12e-05	4	66	2	34099715
Pubmed	The intrinsic and extrinsic effects of TET proteins during gastrulation.	TET2 TET1	2.12e-05	4	66	2	35908548
Pubmed	Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.	TAOK2 TAOK1	3.53e-05	5	66	2	13679851
Pubmed	DNA demethylation fine-tunes IL-2 production during thymic regulatory T cell differentiation.	TET2 TET1	3.53e-05	5	66	2	36880575
Cytoband	9q34.13	SETX NIBAN2	4.20e-04	21	66	2	9q34.13
Cytoband	4q24	TET2 EMCN	1.11e-03	34	66	2	4q24
GeneFamily	EMI domain containing	EMID1 EMILIN3 EMILIN1	5.36e-07	7	46	3	540
GeneFamily	Myosin heavy chains	MYH6 MYH7B	6.51e-04	15	46	2	1098
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	TAOK2 TAOK1	1.69e-03	24	46	2	654
GeneFamily	Cyclins\|Mediator complex	MED12L MED12	3.18e-03	33	46	2	1061
Coexpression	GSE40274_HELIOS_VS_FOXP3_AND_HELIOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	SPPL2A CCR9 TET1 TM6SF1 EMILIN1 ATP6V0A2 SLC12A5	5.64e-07	199	64	7	M9168
Coexpression	GSE41867_LCMV_ARMSTRONG_VS_CLONE13_DAY15_EFFECTOR_CD8_TCELL_DN	FOXO3 DENND4A NPY4R MYH7B MIER3 CSMD1	6.28e-06	186	64	6	M9510
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMID1 GPR37L1 CALY HAS2 CSMD1 SHISAL1	3.20e-07	184	66	6	278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMID1 GPR37L1 CALY HAS2 CSMD1 SHISAL1	3.20e-07	184	66	6	8d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMID1 GPR37L1 CALY CSMD1 SHISAL1	7.11e-06	180	66	5	fa819df81fca95c2cc602fede635cb03e3f35fad
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMID1 GPR37L1 CALY CSMD1 SHISAL1	7.11e-06	180	66	5	907cd510fd2e21532ce04ba687e8894f7af71f27
ToppCell	facs-Heart-LV-3m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ILRUN MYH6 TET1 MED12L HHATL	8.78e-06	188	66	5	40ce7125fca6f6b6b5cc1637c87d43c29b08f4f1
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR37L1 GRIK3 CSMD1 GRM5 SHISAL1	8.78e-06	188	66	5	a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCell	facs-Heart-LV-3m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ILRUN MYH6 TET1 MED12L HHATL	8.78e-06	188	66	5	ba7f7ce034c0f42742bf2461f68f8d343ee593a5
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR37L1 GRIK3 CSMD1 GRM5 SHISAL1	8.78e-06	188	66	5	c8530c9ff98666c64a94683261af4288cb790a7e
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	C1orf220 MYH7B TRIM34 NKRF SLC12A5	1.10e-05	197	66	5	fd76cc5e12c7e7943a48f739e4f0626ff7211f51
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	PITPNM2 SETX PSEN2 KAT6A EMCN	1.18e-05	200	66	5	432384faeade8e609154fab3d96c955a8ec868dd
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-9\|TCGA-Kidney / Sample_Type by Project: Shred V9	HTR1E PSEN2 KCNQ1 TMEM101	4.43e-05	132	66	4	f1ef63a4842ab6ca584a9dcc2dd5b2108fc990aa
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EMID1 GRIK3 CHRM1 EMCN	9.13e-05	159	66	4	d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_D3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SLC16A5 CCR9 MED12L GPR37L1	9.58e-05	161	66	4	3e5a125a25d55bf27652f456239b00b315d54d91
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	CCR9 EMID1 MED12L EMILIN1	1.05e-04	165	66	4	7b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CALY SHISAL1 SLC12A5	1.08e-04	166	66	4	ec7bd549bda5f18aca8aebce5ba479a81abbbeda
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Tac1_(Interneuron,_Basket_1)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PDE6C SLC16A5 NPY4R	1.23e-04	65	66	3	25d2f56f6cd982a227772f8a3b453cdcc8516a47
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1-Inhibitory_Neuron.Gad1Gad2_Pvalb.Tac1_(Interneuron,_Basket_1)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PDE6C SLC16A5 NPY4R	1.23e-04	65	66	3	d7d571be0662967e6d8d934e45f928a2f9e1c06a
ToppCell	Healthy_donor-HSPC\|Healthy_donor / disease group, cell group and cell class (v2)	CCR9 EMID1 MED12L GRB10	1.24e-04	172	66	4	bc7549faadfc92c683c0e26bea380458706774b5
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GPR37L1 HAS2 IL1RAP SHISAL1	1.41e-04	178	66	4	b1357ceb84b83fab53c0394c1af73cbd009f571a
ToppCell	droplet-Bladder-nan-24m-Epithelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR37L1 CALY GRIK3 CSMD1	1.44e-04	179	66	4	dfd9d29281510d32f1a2e8336d2e58ef496cfd1d
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR37L1 GRIK3 CSMD1 IL1RAP	1.47e-04	180	66	4	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR37L1 GRIK3 CSMD1 IL1RAP	1.47e-04	180	66	4	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR37L1 GRIK3 CSMD1 IL1RAP	1.47e-04	180	66	4	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CCR9 CSMD1 PRLR	1.50e-04	181	66	4	cd46eba2e03fd15d8de8e875793ae2f51fa98b3b
ToppCell	droplet-Marrow-BM-30m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CCR9 CSMD1 PRLR	1.50e-04	181	66	4	c7d12c7de227c9433ec2303b8929e957b833f59b
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETX TET1 MIER1 EMCN	1.54e-04	182	66	4	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR37L1 GRIK3 CSMD1 IL1RAP	1.54e-04	182	66	4	6fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SETX TET1 MIER1 EMCN	1.54e-04	182	66	4	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CCR9 NABP1 MIER1	1.60e-04	184	66	4	b80d3f2b76927842a54bc89a87cd70469a6d825a
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CCR9 NABP1 MIER1	1.63e-04	185	66	4	7acc071ea75442817db4d98bd3ed3fff6f0a9d46
ToppCell	facs-Thymus-Flowthrough-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CCR9 NABP1 MIER1	1.63e-04	185	66	4	dc59b8dc459a3c444c9634a0d438cbef54c40036
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNM2 CSMD1 GRM5 SLC12A5	1.67e-04	186	66	4	7278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell	facs-Thymus-Flowthrough-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CCR9 NABP1 MIER1	1.74e-04	188	66	4	59b71462338a7efbacf46577cb07e9db3363afee
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HTR1E MYH7B CALY SHISAL1	1.81e-04	190	66	4	40d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HTR1E MYH7B CALY SHISAL1	1.81e-04	190	66	4	f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HTR1E MYH7B CALY SHISAL1	1.81e-04	190	66	4	a9a705455019e28d655636de73b07540798f82e6
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMID1 GPR37L1 GRIK3 CSMD1	1.81e-04	190	66	4	9b825b2586c7b173ff27fcf2abc5860faf50984a
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMID1 GPR37L1 GRIK3 CSMD1	1.81e-04	190	66	4	d146af1926474328a7c822bc140c4dda66e1bbfb
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Tac1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC16A5 NPY4R HHATL	1.81e-04	74	66	3	c652ef04a1b8716b954ce913daa481cc02f4d44e
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 MED12L KCNQ1 HHATL	1.88e-04	192	66	4	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	facs-Thymus-Flowthrough-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CCR9 NABP1 MIER1	1.88e-04	192	66	4	7a0ef1702d6538e5611cfdc633d8558f9523845c
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-immature_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CCR9 NABP1 MIER1	1.88e-04	192	66	4	cd9bccbef1ef6bb39c310039884e2acb81e63c7c
ToppCell	facs-Thymus-Flowthrough-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CCR9 NABP1 MIER1	1.88e-04	192	66	4	05043fb75319b64f5ed7aee6a232309dcae891b8
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH6 MED12L KCNQ1 HHATL	1.88e-04	192	66	4	d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A KAT6A MED12L TAOK1	1.92e-04	193	66	4	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CCR9 NABP1 MIER1	1.92e-04	193	66	4	a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCell	LAM-LAM-LAM+\|LAM / Condition, Lineage and Cell class	SHISAL1 EMILIN1 PRLR HHATL	1.96e-04	194	66	4	4ba73a9145ed44896e359f6df9c1f32bbe24a189
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CALY TAOK1 GRM5 SLC12A5	1.96e-04	194	66	4	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	LAM-LAM\|LAM / Condition, Lineage and Cell class	SHISAL1 EMILIN1 PRLR HHATL	1.96e-04	194	66	4	4c6561a64711c72c4ef4a3e67c41d2e8d31fba57
ToppCell	facs-Thymus-nan-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC16A5 CCR9 NABP1 MIER1	2.00e-04	195	66	4	79114b3c78cc15c413bb58f0673e7215b784a9b6
ToppCell	facs-Aorta-Heart-3m-Endothelial-aorta_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMID1 KCNQ1 PTPRU EMCN	2.00e-04	195	66	4	3969b8d5fcec8ef1831531a781f7bbcebab5a4ba
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SSH1 EMID1 GRB10 EMCN	2.04e-04	196	66	4	7cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SSH1 EMID1 GRB10 EMCN	2.04e-04	196	66	4	4cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HTR1E MYH7B MED12L CALY	2.04e-04	196	66	4	95544097577f20ed7f4144bd940471cde0617554
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	EMID1 MED12L GRB10 EMILIN1	2.04e-04	196	66	4	b8b9801181d7604871b48aebacb295d0a57a5eaf
ToppCell	Striatum-Neuronal-Excitatory\|Striatum / BrainAtlas - Mouse McCarroll V32	PI4KA CALY GRM5 CHRM1	2.04e-04	196	66	4	67400193ba469cf4d939e94f5ed94995e384bc07
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega\|Control_saline / Treatment groups by lineage, cell group, cell type	FOXO3 DENND4A MED12L PNKD	2.12e-04	198	66	4	1a39a98beef68e1e6d3adc25270a3336fcc5baf4
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|Control_saline / Treatment groups by lineage, cell group, cell type	FOXO3 DENND4A MED12L PNKD	2.12e-04	198	66	4	dd80fd9671ee863aebcf4c1023d3e004cc2ee709
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary\|Control_saline / Treatment groups by lineage, cell group, cell type	FOXO3 DENND4A MED12L PNKD	2.12e-04	198	66	4	cfc2a860bae883299987d3e374d0476ca20e1bdd
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CALY CSMD1 GRM5 SLC12A5	2.12e-04	198	66	4	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FOXO3 DENND4A MED12L PNKD	2.16e-04	199	66	4	565404c155dfac57c020a8f2d09cbf756da20ffd
ToppCell	COPD-Myeloid-Macrophage\|Myeloid / Disease state, Lineage and Cell class	FOXO3 TET2 SSH1 CSMD1	2.16e-04	199	66	4	1cf1b2d6debf9e3389f1829dcaa2857e9533a080
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR37L1 CSMD1 GRM5 CHRM1	2.16e-04	199	66	4	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR37L1 CSMD1 GRM5 CHRM1	2.16e-04	199	66	4	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR37L1 CSMD1 GRM5 CHRM1	2.16e-04	199	66	4	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PITPNM2 SETX KAT6A EMCN	2.20e-04	200	66	4	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HTR1E CALY CHRM1 SLC12A5	2.20e-04	200	66	4	2f481e2fd248c02a5aa2e0248c16808df142fed2
ToppCell	Striatum-Neuronal\|Striatum / BrainAtlas - Mouse McCarroll V32	PI4KA CALY GRM5 SLC12A5	2.20e-04	200	66	4	c888fd487990cad482a4ca47601cdebc0ca3f3ce
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PITPNM2 SETX KAT6A EMCN	2.20e-04	200	66	4	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	Macroglial-Polydendrocytes-PDGFRA-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GRIK3 CSMD1 GRM5 IL1RAP	2.20e-04	200	66	4	f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCell	Macroglial-Polydendrocytes-PDGFRA--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GRIK3 CSMD1 GRM5 IL1RAP	2.20e-04	200	66	4	cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron-Neuron-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HTR1E CALY CHRM1 SLC12A5	2.20e-04	200	66	4	bd4b9f6b37f4a3c960c4149cf0cfd2caf3327d2d
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PITPNM2 SETX KAT6A EMCN	2.20e-04	200	66	4	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PITPNM2 SETX KAT6A EMCN	2.20e-04	200	66	4	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	Macroglial-Polydendrocytes-PDGFRA\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GRIK3 CSMD1 GRM5 IL1RAP	2.20e-04	200	66	4	c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PITPNM2 SETX KAT6A EMCN	2.20e-04	200	66	4	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PITPNM2 SETX PSEN2 EMCN	2.20e-04	200	66	4	66f7e8ee63c828f17468e79a4b816346b33e8980
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	GPR37L1 CSMD1 GRM5 CHRM1	2.20e-04	200	66	4	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Neuron\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HTR1E CALY CHRM1 SLC12A5	2.20e-04	200	66	4	dc674124475edf83908b51a4e1454bc2dc4f06fa
ToppCell	Macroglial-Polydendrocytes-PDGFRA---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GRIK3 CSMD1 GRM5 IL1RAP	2.20e-04	200	66	4	4fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCell	Macroglial-Polydendrocytes-PDGFRA----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GRIK3 CSMD1 GRM5 IL1RAP	2.20e-04	200	66	4	310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCell	Macroglial-Polydendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GRIK3 CSMD1 GRM5 IL1RAP	2.20e-04	200	66	4	961858738ce35db8760c8c2e136f8369bc444ccf
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EMID1 EMILIN3 HAS2	3.13e-04	89	66	3	b66575739cb5b89234bbb8a3ea2f244e0bd19cff
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EMID1 EMILIN3 HAS2	3.13e-04	89	66	3	26f01e8530b313dd5e95ea6c20fa362e34b9ed24
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EMID1 EMILIN3 HAS2	3.23e-04	90	66	3	a0baaf2b3cf07d457f0d242fc213689cba6fd449
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P3-Tnr\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EMID1 EMILIN3 HAS2	3.23e-04	90	66	3	ab4b08c6ac8695b38f841c0ecf2bb2c032111d04
Disease	Schizophrenia	PSEN2 PI4KA TET1 GRB10 CALY GRIK3 CSMD1 GRM5 CHRM1 MED12 SLC12A5	3.32e-06	883	65	11	C0036341
Disease	mean arterial pressure, response to high sodium diet	KCNQ1 CSMD1	2.13e-04	10	65	2	EFO_0005401, EFO_0006340
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH6 MYH7B	2.13e-04	10	65	2	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH6 MYH7B	2.13e-04	10	65	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH6 MYH7B	2.13e-04	10	65	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH6 MYH7B	2.13e-04	10	65	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH6 MYH7B	2.13e-04	10	65	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH6 MYH7B	2.13e-04	10	65	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH6 MYH7B	2.13e-04	10	65	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH6 MYH7B	2.13e-04	10	65	2	DOID:0111596 (implicated_via_orthology)
Disease	neuroticism measurement, cognitive function measurement	FOXO3 TET2 PSEN2 GRIK3 PTPRU CSMD1 GRM5	2.45e-04	566	65	7	EFO_0007660, EFO_0008354
Disease	distal myopathy (implicated_via_orthology)	MYH6 MYH7B	3.11e-04	12	65	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH6 MYH7B	3.11e-04	12	65	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH6 MYH7B	3.67e-04	13	65	2	DOID:397 (implicated_via_orthology)
Disease	unipolar depression, bipolar disorder	MYO1G EMILIN3 GRIK3 GRM5	3.96e-04	156	65	4	EFO_0003761, MONDO_0004985
Disease	fasting blood glucose measurement	PDE6C MIER3 GRB10 KCNQ1 CSMD1	4.31e-04	287	65	5	EFO_0004465
Disease	Petit mal status	CCR9 GRM5 SLC12A5	4.42e-04	67	65	3	C0270823
Disease	Grand Mal Status Epilepticus	CCR9 GRM5 SLC12A5	4.42e-04	67	65	3	C0311335
Disease	Status Epilepticus, Subclinical	CCR9 GRM5 SLC12A5	4.42e-04	67	65	3	C0751522
Disease	Simple Partial Status Epilepticus	CCR9 GRM5 SLC12A5	4.42e-04	67	65	3	C0751524
Disease	Non-Convulsive Status Epilepticus	CCR9 GRM5 SLC12A5	4.42e-04	67	65	3	C0751523
Disease	Complex Partial Status Epilepticus	CCR9 GRM5 SLC12A5	4.42e-04	67	65	3	C0393734
Disease	reticulocyte count	FOXO3 MYO1G PITPNM2 DENND4A EMID1 NABP1 PNKD MED12 SLC12A5	4.56e-04	1045	65	9	EFO_0007986
Disease	Status Epilepticus	CCR9 GRM5 SLC12A5	4.62e-04	68	65	3	C0038220
Disease	distal arthrogryposis (implicated_via_orthology)	MYH6 MYH7B	4.93e-04	15	65	2	DOID:0050646 (implicated_via_orthology)
Disease	central nervous system disease (implicated_via_orthology)	TAOK2 TAOK1	5.62e-04	16	65	2	DOID:331 (implicated_via_orthology)
Disease	reaction time measurement	FOXO3 MYO1G TET2 TET1 GRIK3 PTPRU CSMD1	6.03e-04	658	65	7	EFO_0008393
Disease	amino acid measurement	SETX GRB10 HAS2 CSMD1 PNKD GRM5 MLYCD	7.19e-04	678	65	7	EFO_0005134
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH6 PSEN2 MYH7B	7.43e-04	80	65	3	DOID:12930 (implicated_via_orthology)
Disease	birth weight, parental genotype effect measurement	NLRP11 TET2 MYH7B KCNQ1	8.63e-04	192	65	4	EFO_0004344, EFO_0005939
Disease	response to ziprasidone	SHISAL1 EMCN	8.85e-04	20	65	2	GO_0097337
Disease	lung cancer	CSMD1 ZRANB1	9.77e-04	21	65	2	MONDO_0008903
Disease	Attention Deficit Disorder	CALY GRM5	1.07e-03	22	65	2	C0041671
Disease	Minimal Brain Dysfunction	CALY GRM5	1.07e-03	22	65	2	C1321905
Disease	Noise-induced hearing loss	KCNQ1 TAOK1	1.07e-03	22	65	2	C0018781
Disease	Epilepsy, Benign Psychomotor, Childhood	GRM5 SLC12A5	1.17e-03	23	65	2	C0393672
Disease	Epilepsy, Lateral Temporal	GRM5 SLC12A5	1.17e-03	23	65	2	C0393682
Disease	Uncinate Epilepsy	GRM5 SLC12A5	1.17e-03	23	65	2	C0014558
Disease	Epilepsy, Temporal Lobe	GRM5 SLC12A5	1.17e-03	23	65	2	C0014556
Disease	Attention deficit hyperactivity disorder	CALY GRM5	1.28e-03	24	65	2	C1263846
Disease	neurotic disorder	GRIK3 CSMD1 GRM5	1.46e-03	101	65	3	EFO_0004257
Disease	Psychotic Disorders	TET1 GRIK3 MED12	1.46e-03	101	65	3	C0033975
Disease	glucose measurement	TET2 PDE6C GRB10 KCNQ1 TAOK1	1.51e-03	380	65	5	EFO_0004468
Disease	neutrophil count, basophil count	MYO1G TET2 SPPL2A PNKD	1.52e-03	224	65	4	EFO_0004833, EFO_0005090
Disease	lumbar disc degeneration	MYH7B CSMD1	1.74e-03	28	65	2	EFO_0004994
Disease	ganglion cell inner plexiform layer thickness measurement	FOXO3 GRB10	1.74e-03	28	65	2	EFO_0600005
Disease	testosterone measurement	ILRUN TET2 DENND4A DRG2 EMID1 NIBAN2 MED12 PRLR MLYCD	1.85e-03	1275	65	9	EFO_0004908
Disease	Primary familial dilated cardiomyopathy	MYH6 PSEN2	2.00e-03	30	65	2	cv:C0340427
Disease	reticulocyte measurement	FOXO3 PITPNM2 DENND4A EMID1 KCNQ1 NABP1 PNKD MED12	2.13e-03	1053	65	8	EFO_0010700

Protein segments in the cluster

Peptide	Gene	Start	Entry
VIYACWEGYKTSGLM	CSMD1	3001	Q96PZ7
IWVKMYGYFAGLCRR	ARMH2	11	H3BNL8
IYIVMDRWKLGYFLC	HTR1E	81	P28566
SMWGSAVYLCYKKSV	DENND4A	186	Q7Z401
YRQSKELYGTWEMLC	NIBAN2	216	Q96TA1
VFVLVGLYRMCWKAD	EMCN	206	Q9ULC0
YVVRLWSAGCRSKYV	KCNQ1	171	P51787
AKYIAFTMYTTCIIW	GRM5	771	P41594
KLRSWMYAVYGALAV	HHATL	96	Q9HCP6
ATWLIKMTCAYYSAI	MED12L	156	Q86YW9
YTIMDYWIFGETLCK	NPY4R	101	P50391
MKSLVYWREICSLFY	NLRP11	616	P59045
MTLLWCVVSLYFYGI	IL1RAP	1	Q9NPH3
TPLMRLCAWYLYGEK	MLYCD	396	O95822
ARWMIYTYSGLFCVT	MYH7B	151	A7E2Y1
TRWMYTVRKGYRAVT	PDE6C	546	P51160
VVWCMAVGISYISVY	NUS1	121	Q96E22
MGYVREYILWAASKS	PI4KA	1666	P42356
AAWLIKMTCAYYAAI	MED12	156	Q93074
YKMDLWSAGCVFYEI	MOK	181	Q9UQ07
TRTVAECVAFYYMWK	MIER3	311	Q7Z3K6
YKLCKVEFRYWGMQS	PITPNM2	191	Q9BZ72
FWRLVYDYGCTSIVM	PTPRU	1261	Q92729
LGRLSYMAYWKSVIL	KAT6A	686	Q92794
KYFMCLVVGITSGVW	FZD5	506	Q13467
MCTATGLYYGDVIWV	ILRUN	161	Q9H6K1
LGCVLIMYKAIWYDQ	CALY	96	Q9NYX4
VGNLSVMCIVWHSYY	GPR37L1	146	O60883
LVYWYCTRVKTMTDM	CCR9	71	P51686
VLIVGTLLYACYWVM	HAS2	511	Q92819
AFYLPVTVMCTLYWR	CHRM1	196	P11229
VTVMCTLYWRIYRET	CHRM1	201	P11229
TRTCWMTAFRLLKYG	GRB10	386	Q13322
YKVMYKIVTAREWRC	EMID1	81	Q96A84
YRVAYKTVTDMEWRC	EMILIN1	106	Q9Y6C2
YKVGYKTVTDLAWRC	EMILIN3	106	Q9NT22
WMYVLLAYLGVSCVL	GRIK3	566	Q13003
MIPVRGLWYCYLQVK	C1orf220	1	Q5T0J3
LVKRIYRLWMFYCAT	SCAMP4	36	Q969E2
RTRSVGECVAFYYMW	MIER1	316	Q8N108
CSWYYALVAMLIAGL	SLC12A5	636	Q9H2X9
SQIYEWMVRCVPYFK	FOXO3	181	O43524
YTTYRLGKTVIMLWH	TAS2R42	76	Q7RTR8
WILGVYCRTYSRHMK	TRIM34	361	Q9BYJ4
RGYASMWKGCLTLYT	NABP1	76	Q96AH0
PMKAVGLAWYSLYTR	PNKD	71	Q8N490
VEYVYERMTGLRWKC	NKRF	466	O15226
TTNYKSYWLGICMLL	SETX	231	Q7Z333
SAMNYDICKVYLARW	SHISAL1	121	Q3SXP7
YKGCYLREHTAWLVM	TAOK1	91	Q7L7X3
YRGCYLREHTAWLVM	TAOK2	91	Q9UL54
EMLWEYLALTCIYTK	DRG2	281	P55039
AWMIYTYSGLFCVTV	MYH6	111	P13533
WADRVRYMVVVYSSG	SSH1	101	Q8WYL5
YMYGTICDIWIASKF	TET1	1181	Q8NFU7
TGYCVYILGVMWSVL	SLC16A5	236	O15375
SWCYTQIKVVKFSYM	SPOP	21	O43791
YKWLVYVMIAIFCIA	SPPL2A	241	Q8TCT8
CHFGKQYTSMWRTYI	PRLR	86	P16471
CYTVMSAIFKWLLLY	UNQ5815/PRO19632	11	Q6UWF5
YTIMDYWIFGETLCK	NPY4R2	101	P0DQD5
KYRCYKFIHGWLIMS	PSEN2	161	P49810
WSMYYNGCKFARSKI	TET2	1291	Q6N021
MSERGIKWACEYCTY	ZRANB1	1	Q9UGI0
YRTIGLYWVGSIIMS	TM6SF1	136	Q9BZW5
YGDWLKVRMYSRTVA	TMEM101	101	Q96IK0
MLWRVCKGYTIVSYA	ATP6V0A2	191	Q9Y487
RFLLRYKMTCEYTWP	MYO1G	646	B0I1T2