Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ethanol binding	ADH1A ADH1C ADH4	1.70e-06	6	89	3	GO:0035276
GeneOntologyMolecularFunction	all-trans-retinol dehydrogenase (NAD+) activity	ADH1A ADH1C ADH4	1.62e-04	24	89	3	GO:0004745
GeneOntologyMolecularFunction	alcohol dehydrogenase (NAD+) activity	ADH1A ADH1C ADH4	2.07e-04	26	89	3	GO:0004022
GeneOntologyMolecularFunction	alcohol dehydrogenase [NAD(P)+] activity	ADH1A ADH1C ADH4	3.19e-04	30	89	3	GO:0018455
GeneOntologyMolecularFunction	ATP-dependent activity	DDX19B DDX19A ERCC6 ZCWPW2 DNAH10 ABCA6 SMCHD1 DNAH17 DDX25 KIF20B	4.02e-04	614	89	10	GO:0140657
GeneOntologyMolecularFunction	RNA helicase activity	DDX19B DDX19A ZCWPW2 DDX25	4.09e-04	78	89	4	GO:0003724
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DDX19B DDX19A ZCWPW2 DDX25	4.50e-04	80	89	4	GO:0008186
GeneOntologyMolecularFunction	helicase activity	DDX19B DDX19A ERCC6 ZCWPW2 DDX25	7.08e-04	158	89	5	GO:0004386
GeneOntologyMolecularFunction	ATP hydrolysis activity	DDX19B DDX19A ERCC6 DNAH10 ABCA6 SMCHD1 DDX25 KIF20B	7.87e-04	441	89	8	GO:0016887
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	SETD5 SETD4 WDR5	9.93e-04	44	89	3	GO:0140938
GeneOntologyMolecularFunction	alcohol binding	OSBPL1A ADH1A ADH1C ADH4	1.12e-03	102	89	4	GO:0043178
GeneOntologyMolecularFunction	histone H3K36 methyltransferase activity	SETD5 SETD4	1.48e-03	13	89	2	GO:0046975
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF33 PRAMEF10 ARIH1 PRAMEF26	4.55e-05	47	88	4	GO:0031462
GeneOntologyCellularComponent	B-WICH complex	ERCC6 SF3B1	4.83e-04	8	88	2	GO:0110016
GeneOntologyCellularComponent	perinuclear region of cytoplasm	ANKRD13B RACK1 PTPRR SYNE1 SPTBN2 OSBPL1A OAS2 SNAP25 DAAM1 CYB5R4 KIF20B MAPK8IP3	5.31e-04	934	88	12	GO:0048471
GeneOntologyCellularComponent	SAGA-type complex	WDR5 TAF5L MAP3K7	5.90e-04	39	88	3	GO:0070461
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	SPTBN1 SPTBN2	6.19e-04	9	88	2	GO:0014731
GeneOntologyCellularComponent	spectrin	SPTBN1 SPTBN2	6.19e-04	9	88	2	GO:0008091
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	DDX19B DDX19A SYNE1 DDX25 XRN1 TAF5L	9.64e-04	269	88	6	GO:0036464
Domain	ADH_Zn_CS	ADH1A ADH1C ADH4	5.19e-06	8	86	3	IPR002328
Domain	ADH_ZINC	ADH1A ADH1C ADH4	5.19e-06	8	86	3	PS00059
Domain	Spectrin/alpha-actinin	SESTD1 SYNE1 SPTBN1 SPTBN2	1.37e-05	32	86	4	IPR018159
Domain	SPEC	SESTD1 SYNE1 SPTBN1 SPTBN2	1.37e-05	32	86	4	SM00150
Domain	CKAP2_C	CKAP2L CKAP2	2.10e-05	2	86	2	IPR029197
Domain	CKAP2_fam	CKAP2L CKAP2	2.10e-05	2	86	2	IPR026165
Domain	CKAP2_C	CKAP2L CKAP2	2.10e-05	2	86	2	PF15297
Domain	G-protein_beta_WD-40_rep	RACK1 STRAP WDR5 TAF5L PAK1IP1	4.52e-05	85	86	5	IPR020472
Domain	ADH_N	ADH1A ADH1C ADH4	5.05e-05	16	86	3	PF08240
Domain	PKS_ER	ADH1A ADH1C ADH4	5.05e-05	16	86	3	SM00829
Domain	PKS_ER	ADH1A ADH1C ADH4	5.05e-05	16	86	3	IPR020843
Domain	ADH_N	ADH1A ADH1C ADH4	5.05e-05	16	86	3	IPR013154
Domain	-	ADH1A ADH1C ADH4	7.32e-05	18	86	3	3.90.180.10
Domain	ADH_zinc_N	ADH1A ADH1C ADH4	8.66e-05	19	86	3	PF00107
Domain	ADH_SF_Zn-type	ADH1A ADH1C ADH4	8.66e-05	19	86	3	IPR002085
Domain	ADH_C	ADH1A ADH1C ADH4	8.66e-05	19	86	3	IPR013149
Domain	Spectrin_bsu	SPTBN1 SPTBN2	1.25e-04	4	86	2	IPR016343
Domain	Actinin_actin-bd_CS	SYNE1 SPTBN1 SPTBN2	1.56e-04	23	86	3	IPR001589
Domain	Spectrin	SYNE1 SPTBN1 SPTBN2	1.56e-04	23	86	3	PF00435
Domain	ACTININ_2	SYNE1 SPTBN1 SPTBN2	1.56e-04	23	86	3	PS00020
Domain	ACTININ_1	SYNE1 SPTBN1 SPTBN2	1.56e-04	23	86	3	PS00019
Domain	GroES-like	ADH1A ADH1C ADH4	1.78e-04	24	86	3	IPR011032
Domain	Spectrin_repeat	SYNE1 SPTBN1 SPTBN2	3.16e-04	29	86	3	IPR002017
Domain	Q_MOTIF	DDX19B DDX19A DDX25	6.54e-04	37	86	3	PS51195
Domain	RNA_helicase_DEAD_Q_motif	DDX19B DDX19A DDX25	6.54e-04	37	86	3	IPR014014
Domain	PH_dom-spectrin-type	SPTBN1 SPTBN2	7.39e-04	9	86	2	IPR001605
Domain	ARM-type_fold	SF3B1 PIK3CD MROH2B EIF2B5 CLTC DAAM1 TANGO6	9.61e-04	339	86	7	IPR016024
Domain	WD40_repeat_CS	RACK1 STRAP WDR5 TAF5L PAK1IP1	9.64e-04	164	86	5	IPR019775
Domain	Helicase_C	DDX19B DDX19A ERCC6 DDX25	1.51e-03	107	86	4	PF00271
Domain	HELICc	DDX19B DDX19A ERCC6 DDX25	1.51e-03	107	86	4	SM00490
Domain	Helicase_C	DDX19B DDX19A ERCC6 DDX25	1.56e-03	108	86	4	IPR001650
Domain	HELICASE_CTER	DDX19B DDX19A ERCC6 DDX25	1.61e-03	109	86	4	PS51194
Domain	HELICASE_ATP_BIND_1	DDX19B DDX19A ERCC6 DDX25	1.61e-03	109	86	4	PS51192
Domain	DEXDc	DDX19B DDX19A ERCC6 DDX25	1.61e-03	109	86	4	SM00487
Domain	Helicase_ATP-bd	DDX19B DDX19A ERCC6 DDX25	1.67e-03	110	86	4	IPR014001
Domain	PH	SPTBN1 SPTBN2 OSBPL1A GRB10 ARAP2 AGAP3	1.79e-03	278	86	6	SM00233
Domain	PH_DOMAIN	SPTBN1 SPTBN2 OSBPL1A GRB10 ARAP2 AGAP3	1.82e-03	279	86	6	PS50003
Domain	PH_domain	SPTBN1 SPTBN2 OSBPL1A GRB10 ARAP2 AGAP3	1.86e-03	280	86	6	IPR001849
Domain	CS_dom	CYB5R4 SHQ1	2.41e-03	16	86	2	IPR007052
Domain	CS	CYB5R4 SHQ1	2.41e-03	16	86	2	PS51203
Domain	WD40_repeat_dom	RACK1 STRAP WDR5 TAF5L PAK1IP1 MAPK8IP3	2.49e-03	297	86	6	IPR017986
Domain	Ank_2	ANKRD36B ANKRD13B SLF1 OSBPL1A AGAP3	3.16e-03	215	86	5	PF12796
Domain	CH	SYNE1 SPTBN1 SPTBN2	3.35e-03	65	86	3	SM00033
Domain	Ank	ANKRD36B ANKRD13B SLF1 OSBPL1A AGAP3	4.05e-03	228	86	5	PF00023
Domain	PH	SPTBN1 SPTBN2 GRB10 ARAP2 AGAP3	4.13e-03	229	86	5	PF00169
Domain	CH	SYNE1 SPTBN1 SPTBN2	4.13e-03	70	86	3	PF00307
Domain	HEAT_REPEAT	SF3B1 MROH2B TANGO6	4.13e-03	70	86	3	PS50077
Domain	-	SYNE1 SPTBN1 SPTBN2	4.30e-03	71	86	3	1.10.418.10
Domain	-	RACK1 STRAP WDR5 TAF5L PAK1IP1 MAPK8IP3	4.37e-03	333	86	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	RACK1 STRAP WDR5 TAF5L PAK1IP1 MAPK8IP3	4.50e-03	335	86	6	IPR015943
Domain	DEAD/DEAH_box_helicase_dom	DDX19B DDX19A DDX25	4.65e-03	73	86	3	IPR011545
Domain	CH	SYNE1 SPTBN1 SPTBN2	4.65e-03	73	86	3	PS50021
Domain	DEAD	DDX19B DDX19A DDX25	4.65e-03	73	86	3	PF00270
Domain	CH-domain	SYNE1 SPTBN1 SPTBN2	5.01e-03	75	86	3	IPR001715
Domain	P-loop_NTPase	DDX19B DDX19A NLRP14 ERCC6 DNAH10 ABCA6 DDX25 MAGI3 KIF20B AGAP3	5.52e-03	848	86	10	IPR027417
Domain	-	ANKRD36B ANKRD13B SLF1 OSBPL1A AGAP3	5.77e-03	248	86	5	1.25.40.20
Domain	ANK	ANKRD36B ANKRD13B SLF1 OSBPL1A AGAP3	6.06e-03	251	86	5	SM00248
Domain	ANK_REPEAT	ANKRD36B ANKRD13B SLF1 OSBPL1A AGAP3	6.27e-03	253	86	5	PS50088
Domain	HSP20-like_chaperone	CYB5R4 SHQ1	6.34e-03	26	86	2	IPR008978
Domain	Ankyrin_rpt-contain_dom	ANKRD36B ANKRD13B SLF1 OSBPL1A AGAP3	6.37e-03	254	86	5	IPR020683
Domain	ANK_REP_REGION	ANKRD36B ANKRD13B SLF1 OSBPL1A AGAP3	6.37e-03	254	86	5	PS50297
Domain	WD40	RACK1 STRAP WDR5 TAF5L PAK1IP1	6.90e-03	259	86	5	PF00400
Domain	Ankyrin_rpt	ANKRD36B ANKRD13B SLF1 OSBPL1A AGAP3	7.24e-03	262	86	5	IPR002110
Domain	ArfGap	ARAP2 AGAP3	7.85e-03	29	86	2	SM00105
Domain	ArfGap	ARAP2 AGAP3	7.85e-03	29	86	2	PF01412
Domain	ARFGAP	ARAP2 AGAP3	7.85e-03	29	86	2	PS50115
Pathway	WP_FATTY_ACID_OMEGAOXIDATION	ADH1A ADH1C ADH4	8.18e-06	10	59	3	MM15833
Pathway	REACTOME_ETHANOL_OXIDATION	ADH1A ADH1C ADH4	1.12e-05	11	59	3	MM15405
Pathway	REACTOME_ETHANOL_OXIDATION	ADH1A ADH1C ADH4	1.49e-05	12	59	3	M14663
Pathway	WP_MEASLES_VIRUS_INFECTION	RACK1 PIK3CD OAS2 TLR7 MAP3K7 CD209	2.14e-05	136	59	6	M42547
Pathway	WP_FATTY_ACID_OMEGAOXIDATION	ADH1A ADH1C ADH4	3.06e-05	15	59	3	M39717
Pathway	WP_7Q1123_COPY_NUMBER_VARIATION_SYNDROME	MLXIPL ERCC6 SF3B1 CLTC SNAP25	7.93e-05	106	59	5	M40052
Pathway	REACTOME_RA_BIOSYNTHESIS_PATHWAY	ADH1A ADH1C ADH4	1.01e-04	22	59	3	M27445
Pathway	REACTOME_RA_BIOSYNTHESIS_PATHWAY	ADH1A ADH1C ADH4	2.12e-04	28	59	3	MM15188
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_INTERFERON_INDUCTION	OAS2 TLR7 MAP3K7	3.47e-04	33	59	3	M39909
Pathway	REACTOME_ABACAVIR_ADME	ADH1A ADH1C	4.74e-04	8	59	2	MM14869
Pathway	WP_INSULIN_SIGNALING	PIK3CD MINK1 GRB10 SNAP25 MAP3K7	5.40e-04	160	59	5	MM15956
Pathway	WP_INSULIN_SIGNALING	PIK3CD MINK1 GRB10 SNAP25 MAP3K7	5.40e-04	160	59	5	M39482
Pathway	KEGG_TYROSINE_METABOLISM	ADH1A ADH1C ADH4	7.12e-04	42	59	3	M16743
Pathway	KEGG_FATTY_ACID_METABOLISM	ADH1A ADH1C ADH4	7.12e-04	42	59	3	M699
Pathway	REACTOME_RSV_HOST_INTERACTIONS	OAS2 TLR7 ARIH1 CD209	7.46e-04	98	59	4	M48247
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	PIK3CD SPTBN1 SPTBN2 CLTC GRB10 DSCAML1	7.53e-04	261	59	6	MM15676
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTBN1 SPTBN2	7.58e-04	10	59	2	MM15112
Pathway	REACTOME_SIGNALING_BY_RETINOIC_ACID	ADH1A ADH1C ADH4	7.63e-04	43	59	3	M27443
Pathway	WP_RETINOL_METABOLISM	ADH1A ADH1C ADH4	8.16e-04	44	59	3	MM15851
Pathway	REACTOME_SIGNALING_BY_RETINOIC_ACID	ADH1A ADH1C ADH4	1.12e-03	49	59	3	MM15186
Pathway	WP_WNT_SIGNALING_PATHWAY	SFRP2 MAGI3 DAAM1 MAP3K7	1.15e-03	110	59	4	MM15977
Pubmed	Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain.	ADH1A ADH1C ADH4	6.69e-08	4	90	3	12631290
Pubmed	Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice.	ADH1A ADH1C ADH4	1.67e-07	5	90	3	11836246
Pubmed	ADH single nucleotide polymorphism associations with alcohol metabolism in vivo.	ADH1A ADH1C ADH4	1.67e-07	5	90	3	19193628
Pubmed	Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease.	ADH1A ADH1C ADH4	1.67e-07	5	90	3	22079585
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	SF3B1 RACK1 SEC62 SPTBN1 MINK1 CLTC XRN1 WDR5 SNAP25 DAAM1 KCNB2 SIPA1L2 MAP3K7 MAPK8IP3 AGAP3	2.25e-07	1139	90	15	36417873
Pubmed	High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease.	ADH1A ADH1C ADH4	3.33e-07	6	90	3	17257171
Pubmed	Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3.	ADH1A ADH1C ADH4	3.33e-07	6	90	3	12027900
Pubmed	Merging protein, gene and genomic data: the evolution of the MDR-ADH family.	ADH1A ADH1C ADH4	3.33e-07	6	90	3	16121213
Pubmed	Human liver alcohol dehydrogenase: purification, composition, and catalytic features.	ADH1A ADH1C ADH4	3.33e-07	6	90	3	9982
Pubmed	Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3.	ADH1A ADH1C ADH4	3.33e-07	6	90	3	518534
Pubmed	Tissue- and species-specific expression patterns of class I, III, and IV Adh and Aldh 1 mRNAs in rodent embryos.	ADH1A ADH1C ADH4	5.82e-07	7	90	3	16047160
Pubmed	Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes.	ADH1A ADH1C ADH4	5.82e-07	7	90	3	11784316
Pubmed	Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.	ADH1A ADH1C ADH4	5.82e-07	7	90	3	23456092
Pubmed	Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism.	ADH1A ADH1C ADH4	5.82e-07	7	90	3	23468174
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	NRDE2 SESTD1 PRAMEF33 PRAMEF10 RACK1 SETD5 PTPRR PIK3CD SPTBN1 CLTC ZBTB41 CKAP2 NCOA4 TTC3	7.50e-07	1084	90	14	11544199
Pubmed	Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.	ADH1A ADH1C ADH4	9.30e-07	8	90	3	18331377
Pubmed	Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally.	ADH1A ADH1C ADH4	1.39e-06	9	90	3	11747070
Pubmed	A functional reference map of the RNF8 interactome in cancer.	SF3B1 RACK1 STRAP IGHG1 SPTBN1 CLTC WDR5	1.66e-06	218	90	7	35831895
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	SLC12A2 RACK1 SPTBN1 MINK1 SPTBN2 XRN1 MAGI3 SNAP25 DAAM1 FAM110C	2.11e-06	565	90	10	25468996
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DDX19B MLXIPL SLC12A2 SPTBN1 MINK1 XRN1 GRB10 MAGI3 CKAP2 SIPA1L2 ARAP2 AGAP3	2.29e-06	861	90	12	36931259
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SP100 SF3B1 SETD5 SYNE1 SMCHD1 SEC62 SPTBN1 SPTBN2 CLTC XRN1 MAGI3 ZBTB41 SIPA1L2 TTC3 RPL3L	4.21e-06	1442	90	15	35575683
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	ERCC6 RACK1 STRAP SMCHD1 EIF2B5 XRN1 CKAP2L WDR5 CKAP2 PAK1IP1 KIF20B	4.33e-06	759	90	11	35915203
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SESTD1 SF3B1 SYNE1 SPTBN1 SPTBN2 CLTC OSBPL1A MAGI3 SNAP25 CKAP2 TTC3 DSCAML1 MAPK8IP3 AGAP3	5.41e-06	1285	90	14	35914814
Pubmed	Association between polymorphisms in OAS2 and CD209 genes and predisposition to chronic hepatitis C in Russian population.	OAS2 CD209	6.62e-06	2	90	2	24594345
Pubmed	Alcohol dehydrogenase 3 genotype is not associated with risk of squamous cell carcinoma of the oral cavity and pharynx.	ADH1A ADH1C	6.62e-06	2	90	2	11303599
Pubmed	Characterization of the aberrant splicing of MAP3K7 induced by cancer-associated SF3B1 mutation.	SF3B1 MAP3K7	6.62e-06	2	90	2	33751071
Pubmed	SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes.	SF3B1 MAP3K7	6.62e-06	2	90	2	34930825
Pubmed	Caspase-3/7-mediated Cleavage of β2-spectrin is Required for Acetaminophen-induced Liver Damage.	SPTBN1 SPTBN2	6.62e-06	2	90	2	26884715
Pubmed	DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation.	DDX19B DDX19A	6.62e-06	2	90	2	30699353
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SESTD1 SF3B1 RACK1 STRAP SYNE1 SPTBN1 MINK1 SPTBN2 CLTC TTC3 MAPK8IP3 PROX1	7.16e-06	963	90	12	28671696
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	NLRP14 ERCC6 SF3B1 RACK1 STRAP SMCHD1 CLTC XRN1 MAP3K7	7.55e-06	513	90	9	25798074
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SESTD1 SYNE1 SPTBN1 MINK1 SPTBN2 CLTC KCNB2	8.79e-06	281	90	7	28706196
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	SF3B1 RACK1 STRAP SPTBN1 MINK1 EIF2B5 CLTC MAP3K7	1.12e-05	408	90	8	33766124
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	DDX19A MLXIPL STRAP EIF2B5 TMED8 XRN1 GRB10 WDR5 NCOA4 MAP3K7 IL33 SHQ1	1.51e-05	1038	90	12	26673895
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DDX19A SF3B1 RACK1 STRAP DNAH10 SYNE1 SMCHD1 SPTBN1 EIF2B5 CLTC WDR5 TAF5L PAK1IP1 TTC3	1.73e-05	1425	90	14	30948266
Pubmed	Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family.	ADH1A ADH1C	1.98e-05	3	90	2	10424757
Pubmed	Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase.	ADH1A ADH1C	1.98e-05	3	90	2	11960985
Pubmed	Tissue-specific genetic variation in the level of mouse alcohol dehydrogenase is controlled transcriptionally in kidney and posttranscriptionally in liver.	ADH1A ADH1C	1.98e-05	3	90	2	2474823
Pubmed	Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes.	MAP3K7 IL33	1.98e-05	3	90	2	20532808
Pubmed	Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization.	ADH1A ADH1C	1.98e-05	3	90	2	2737681
Pubmed	Regulation of human class I alcohol dehydrogenases by bile acids.	ADH1A ADH1C	1.98e-05	3	90	2	23772048
Pubmed	A negative regulatory element upstream from the mouse Adh-1 gene can down-regulate a heterologous promoter.	ADH1A ADH1C	1.98e-05	3	90	2	8163197
Pubmed	ALDH expression characterizes G1-phase proliferating beta cells during pregnancy.	ADH1A ADH1C	1.98e-05	3	90	2	24787690
Pubmed	The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome.	ADH1A ADH1C	1.98e-05	3	90	2	2347582
Pubmed	Androgen induction of alcohol dehydrogenase in mouse kidney. Studies with a cDNA probe confirmed by nucleotide sequence analysis.	ADH1A ADH1C	1.98e-05	3	90	2	3011597
Pubmed	Alcohol dehydrogenase isozymes in the mouse: genetic regulation, allelic variation among inbred strains and sex differences of liver and kidney A2 isozyme activity.	ADH1A ADH1C	1.98e-05	3	90	2	6756216
Pubmed	Beneficial effect of low ethanol intake on the cardiovascular system: possible biochemical mechanisms.	ADH1A ADH1C	1.98e-05	3	90	2	17326332
Pubmed	The role of alcohol dehydrogenase in retinoic acid homeostasis and fetal alcohol syndrome.	ADH1A ADH1C	1.98e-05	3	90	2	7748347
Pubmed	Alcohol dehydrogenase 1 is a tubular mitophagy-dependent apoptosis inhibitor against septic acute kidney injury.	ADH1A ADH1C	1.98e-05	3	90	2	37806378
Pubmed	Structure and function of a long alternating purine-pyrimidine sequence in the mouse alcohol dehydrogenase Adh-1 gene.	ADH1A ADH1C	1.98e-05	3	90	2	7840644
Pubmed	Genetics of human alcohol and aldehyde dehydrogenases.	ADH1A ADH1C	1.98e-05	3	90	2	3006456
Pubmed	RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1.	DDX19B DDX19A	1.98e-05	3	90	2	25585691
Pubmed	Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice.	ADH1A ADH1C	1.98e-05	3	90	2	9145544
Pubmed	Structure of the mouse Adh-1 gene and identification of a deletion in a long alternating purine-pyrimidine sequence in the first intron of strains expressing low alcohol dehydrogenase activity.	ADH1A ADH1C	1.98e-05	3	90	2	3428612
Pubmed	Genetic and developmental regulation of mouse liver alcohol dehydrogenase.	ADH1A ADH1C	1.98e-05	3	90	2	6816803
Pubmed	Respiratory macrophages and dendritic cells mediate respiratory syncytial virus-induced IL-33 production in TLR3- or TLR7-dependent manner.	TLR7 IL33	1.98e-05	3	90	2	26603638
Pubmed	Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population.	ADH1C ADH4	1.98e-05	3	90	2	14745297
Pubmed	Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis.	ADH1A ADH1C	1.98e-05	3	90	2	15670660
Pubmed	Ten kilobases of 5'-flanking region confers proper regulation of the mouse alcohol dehydrogenase-1 (Adh-1) gene in kidney and adrenal of transgenic mice.	ADH1A ADH1C	1.98e-05	3	90	2	8973327
Pubmed	The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role.	ADH1A ADH1C	1.98e-05	3	90	2	15554233
Pubmed	ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.	ADH1A ADH1C	1.98e-05	3	90	2	35354963
Pubmed	Purification and characterization of mouse alcohol dehydrogenase from two inbred strains that differ in total liver enzyme activity.	ADH1A ADH1C	1.98e-05	3	90	2	6370228
Pubmed	Stage and tissue-specific expression of the alcohol dehydrogenase 1 (Adh-1) gene during mouse development.	ADH1A ADH1C	1.98e-05	3	90	2	8018987
Pubmed	Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1.	ADH1A ADH1C	1.98e-05	3	90	2	33586683
Pubmed	Cloning and sequencing of cDNA encoding the complete mouse liver alcohol dehydrogenase.	ADH1A ADH1C	1.98e-05	3	90	2	3157987
Pubmed	Promoters for the human alcohol dehydrogenase genes ADH1, ADH2, and ADH3: interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box.	ADH1A ADH1C	1.98e-05	3	90	2	2169444
Pubmed	A novel negative element in the promoter of the mouse alcohol dehydrogenase gene Adh-1.	ADH1A ADH1C	1.98e-05	3	90	2	8486690
Pubmed	Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.	ADH1A ADH1C	1.98e-05	3	90	2	2935875
Pubmed	Individual susceptibility and alcohol effects:biochemical and genetic aspects.	ADH1A ADH1C	1.98e-05	3	90	2	16801720
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SP100 ERCC6 SF3B1 RACK1 STRAP SMCHD1 SPTBN1 SPTBN2 CLTC WDR5 CKAP2 PAK1IP1 KIF20B	2.10e-05	1257	90	13	36526897
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	SPTBN2 GRB10 MAGI3 DSCAML1 TANGO6	2.30e-05	130	90	5	12421765
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF33 PRAMEF10 PRAMEF26	2.49e-05	22	90	3	31729367
Pubmed	Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid.	ADH1A ADH1C ADH4	2.49e-05	22	90	3	10753524
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	NRDE2 ERCC6 SLC12A2 RACK1 SETD5 SYNE1 MINK1 XRN1 TAF5L DAAM1 CKAP2 PAK1IP1 KIF20B AGAP3	2.98e-05	1497	90	14	31527615
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SP100 ERCC6 RACK1 SETD5 TCP11L1 XRN1 TAF5L SIPA1L2 ARAP2 PROX1 AGAP3 ADH4	3.07e-05	1116	90	12	31753913
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TDRD15 SF3B1 SLC12A2 RACK1 MINK1 CLTC XRN1 MAP3K7 ARAP2 AGAP3	3.34e-05	777	90	10	35844135
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF33 PRAMEF10 PRAMEF26	3.70e-05	25	90	3	37451217
Pubmed	Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.	SLC12A2 PROX1	3.96e-05	4	90	2	28453575
Pubmed	Overexpression of alcohol dehydrogenase exacerbates ethanol-induced contractile defect in cardiac myocytes.	ADH1A ADH1C	3.96e-05	4	90	2	11893554
Pubmed	Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in mice.	ADH1A ADH1C	3.96e-05	4	90	2	29663519
Pubmed	Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid.	ADH1A ADH1C	3.96e-05	4	90	2	12851412
Pubmed	ADH1 and ADH4 alcohol/retinol dehydrogenases in the developing adrenal blastema provide evidence for embryonic retinoid endocrine function.	ADH1A ADH1C	3.96e-05	4	90	2	9733106
Pubmed	Hepatic CYP2B10 is highly induced by binge ethanol and contributes to acute-on-chronic alcohol-induced liver injury.	ADH1A ADH1C	3.96e-05	4	90	2	36224745
Pubmed	Retinoic acid and alcohol/retinol dehydrogenase in the mouse adrenal gland: a potential endocrine source of retinoic acid during development.	ADH1A ADH1C	3.96e-05	4	90	2	9202249
Pubmed	Genetic regulation of gene-specific mRNA by ethanol in vivo and its possible role in ethanol preference in a cross with RI lines in mice.	ADH1A ADH1C	3.96e-05	4	90	2	8813054
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTBN1 SPTBN2	3.96e-05	4	90	2	21412925
Pubmed	Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells.	ADH1A ADH1C	3.96e-05	4	90	2	19618839
Pubmed	Mouse mitochondrial aldehyde dehydrogenase isozymes: purification and molecular properties.	ADH1A ADH1C	3.96e-05	4	90	2	3996732
Pubmed	Genetic mapping of a possible new alcohol dehydrogenase sequence to mouse chromosome 3 at the Adh-1/Adh-3 complex.	ADH1A ADH1C	3.96e-05	4	90	2	9241435
Pubmed	Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid.	ADH1A ADH1C	3.96e-05	4	90	2	10880953
Pubmed	Molecular analysis of mouse alcohol dehydrogenase: nucleotide sequence of the Adh-1 gene and genetic mapping of a related nucleotide sequence to chromosome 3.	ADH1A ADH1C	3.96e-05	4	90	2	2893758
Pubmed	Localization of class I and class IV alcohol dehydrogenases in mouse testis and epididymis: potential retinol dehydrogenases for endogenous retinoic acid synthesis.	ADH1A ADH1C	3.96e-05	4	90	2	9002638
Pubmed	Loss of β2-spectrin prevents cardiomyocyte differentiation and heart development.	SPTBN1 SPTBN2	3.96e-05	4	90	2	24064296
Pubmed	Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation.	ADH1A ADH1C	3.96e-05	4	90	2	15193143
Pubmed	A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.	ADH1A ADH4	3.96e-05	4	90	2	19687126
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	SF3B1 RACK1 STRAP SPTBN1 CLTC WDR5 ARIH1 KIF20B	4.38e-05	494	90	8	26831064
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	MLXIPL SF3B1 RACK1 STRAP SMCHD1 SPTBN1 CLTC CKAP2 MAP3K7 KIF20B	4.69e-05	809	90	10	32129710
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	ANKRD36B NRDE2 SF3B1 RACK1 STRAP SMCHD1 SEC62 SPTBN1 SPTBN2 CLTC CKAP2L WDR5 PAK1IP1	5.13e-05	1371	90	13	36244648
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF33 PRAMEF10 PRAMEF26	5.24e-05	28	90	3	25089626
Pubmed	Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis.	ADH1A ADH1C	6.59e-05	5	90	2	8892527
Interaction	DDX25 interactions	DDX19B DDX19A DDX25	4.28e-06	8	87	3	int:DDX25
Interaction	ADH1B interactions	RACK1 ADH1A ADH1C	2.15e-05	13	87	3	int:ADH1B
Interaction	HSP90B1 interactions	RACK1 DNAH10 PTPRR SEC62 SPTBN1 DNAH17 CLTC WDR5 DAAM1 SIPA1L2 MAP3K7 KIF20B	2.23e-05	650	87	12	int:HSP90B1
Cytoband	Ensembl 112 genes in cytogenetic band chr4q23	ADH1A ADH1C ADH4	5.39e-05	37	90	3	chr4q23
Cytoband	1p36.21	PRAMEF33 PRAMEF10 PRAMEF26	2.66e-04	63	90	3	1p36.21
Cytoband	4q23	ADH1A ADH1C	7.06e-04	20	90	2	4q23
GeneFamily	Alcohol dehydrogenases	ADH1A ADH1C ADH4	2.02e-06	8	61	3	397
GeneFamily	Ankyrin repeat domain containing	ANKRD36B ANKRD13B SLF1 OSBPL1A ARAP2 AGAP3	1.62e-04	242	61	6	403
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN1 SPTBN2	2.33e-04	7	61	2	1113
GeneFamily	DEAD-box helicases	DDX19B DDX19A DDX25	3.82e-04	42	61	3	499
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SPTBN1 SPTBN2 GRB10 ARAP2 AGAP3	6.48e-04	206	61	5	682
GeneFamily	Dyneins, axonemal	DNAH10 DNAH17	1.47e-03	17	61	2	536
GeneFamily	WD repeat domain containing	RACK1 STRAP WDR5 TAF5L PAK1IP1	1.89e-03	262	61	5	362
GeneFamily	PRAME family	PRAMEF10 PRAMEF26	2.95e-03	24	61	2	686
GeneFamily	Nucleoporins	DDX19B DDX19A	5.20e-03	32	61	2	1051
GeneFamily	ArfGAPs	ARAP2 AGAP3	5.53e-03	33	61	2	395
ToppCell	COVID-19_Moderate\|World / disease group, cell group and cell class	ANKRD36B SP100 IGHG1 SYNE1 SMCHD1 SPTBN1 XRN1 OAS2	7.23e-09	199	90	8	952fac67588ad5676f5939e3c7f8bac803c27064
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	SLF1 SLC12A2 SMCHD1 SPTBN1 XRN1 OAS2 DOC2B	1.69e-07	200	90	7	edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCell	COPD-Endothelial-VE_Venous\|COPD / Disease state, Lineage and Cell class	ZCWPW2 PTPRR SPTBN1 GRB10 IL33 DOC2B	2.02e-06	184	90	6	44d716e7ba46a1ed03f5992631289653f8fd7d5e
ToppCell	COPD-Endothelial-VE_Arterial\|COPD / Disease state, Lineage and Cell class	ZCWPW2 PTPRR SPTBN1 GRB10 IL33 DOC2B	2.66e-06	193	90	6	1c701b6ab5f0f0239634adac94fa1c92bf3c36f4
ToppCell	COPD-Endothelial\|COPD / Disease state, Lineage and Cell class	ZCWPW2 SPTBN1 GRB10 IL33 PROX1 DOC2B	2.66e-06	193	90	6	093b28dcccb5841c995d0b33fae0efd6b88f97e0
ToppCell	IPF-Endothelial-VE_Venous\|IPF / Disease state, Lineage and Cell class	ZCWPW2 PTPRR SPTBN1 GRB10 IL33 DOC2B	2.66e-06	193	90	6	29a655fa80feaabe846c90a28363b037e22d24ae
ToppCell	IPF-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	ZCWPW2 PTPRR SPTBN1 GRB10 IL33 DOC2B	2.66e-06	193	90	6	ef66a46e7ab44fcc4005a23416e6da478a4cce37
ToppCell	Fibroblasts-CD34+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	SFRP2 ABCA6 OSBPL1A GRB10 IL33 ADH4	2.82e-06	195	90	6	c6b5249ac8714b1b701cde31d00ab53f28355c36
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD36B SLF1 PTPRR SNAP25 KCNB2 TTC3	3.08e-06	198	90	6	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	ANKRD36B SLF1 PTPRR SYNE1 SNAP25 KCNB2	3.27e-06	200	90	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SP100 SLC12A2 SMCHD1 SPTBN1 XRN1 OAS2	3.27e-06	200	90	6	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SLC12A2 SMCHD1 SPTBN1 OSBPL1A OAS2 SIPA1L2	3.27e-06	200	90	6	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SP100 SF3B1 SMCHD1 XRN1 OAS2 ARAP2	3.27e-06	200	90	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	VE\|World / Condition, Cell_class and T cell subcluster	SP100 SF3B1 SMCHD1 XRN1 OAS2 ARAP2	3.27e-06	200	90	6	8ae7cb81de3ffac5acdf3466d4b516d80cac95d3
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Cortical_neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	SYNE1 SPTBN1 DDX25 SNAP25 NCOA4 TTC3	3.27e-06	200	90	6	44bc4d6616fc8d0ad8498e56125939034e8cff01
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	SP100 SF3B1 IGHG1 SMCHD1 XRN1 OAS2	3.27e-06	200	90	6	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	Endothelial-Endothelial-H_(cycle)\|Endothelial / shred on cell class and cell subclass (v4)	CKAP2L CKAP2 DSCAML1 KIF20B DOC2B	9.00e-06	138	90	5	a1f41a5a9da40adcc343722baef78c603599c3f0
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-EECs\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SNAP25 KCNB2 DSCAML1 ADH1A ADH4	1.95e-05	162	90	5	478cf560ef33c5c324142c76417447d4a571a2c9
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PARP11 ZBTB41 SNAP25 CKAP2 DOC2B	2.13e-05	165	90	5	7c771f22b58989572c939ed127e637ec28dc0dca
ToppCell	5'-Adult-LymphNode-Hematopoietic-Plasma_cells-IgG_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANKRD36B TDRD15 IGHG1 SMCHD1 XRN1	2.33e-05	168	90	5	f5a18123f84c62211d9279e9c41e90122e4c4895
ToppCell	Basal_cells-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	MXRA5 IL33 ARAP2 ADH1C DOC2B	2.46e-05	170	90	5	776d4224a682b6c648041827efd69794f88906f0
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPTBN1 GRB10 SIPA1L2 IL33 DOC2B	2.53e-05	171	90	5	b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-intermediate_neuroendocrine\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	USP6 SPTBN2 SNAP25 KCNB2 DSCAML1	2.53e-05	171	90	5	b7cddb8f726a43fb8a37f3e67a3f722e2178fd7a
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MLXIPL SFRP2 ABCA6 KCNB2 ADH4	2.60e-05	172	90	5	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	droplet-Limb_Muscle-nan-24m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD13B MLXIPL MINK1 DNAH17 KIF20B	3.07e-05	178	90	5	f2002a5c4758d0af6c1880ca12f0af0d5e8888e4
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SP100 SYNE1 SMCHD1 XRN1 ARAP2	3.07e-05	178	90	5	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	COPD-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	ZCWPW2 PTPRR SPTBN1 IL33 DOC2B	3.15e-05	179	90	5	9968da1adcb561d9bf167a42ab5d9de85c071c4a
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD13B CKAP2L CKAP2 FAM110C PROX1	3.24e-05	180	90	5	43fd5c498a87bb078d101298b472656f3294686a
ToppCell	Epithelial-lung_neuroendocrine_cell_(PNEC)\|World / Lineage, Cell type, age group and donor	DDX25 SNAP25 KCNB2 DSCAML1 PROX1	3.41e-05	182	90	5	57bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	USP6 DDX25 IL33 PROX1 DOC2B	3.59e-05	184	90	5	30ca56d64c961127e26122613e35aa2b46fde2df
ToppCell	T_cells-ISG-high_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	PARP11 SP100 SMCHD1 XRN1 OAS2	3.98e-05	188	90	5	6f8946d4710f6e32c937213f99b790b098b8819c
ToppCell	Control-Endothelial-VE_Venous\|World / Disease state, Lineage and Cell class	ZCWPW2 PTPRR SPTBN1 IL33 DOC2B	4.08e-05	189	90	5	f83f7521e377ded1522639e9a35c98b3e2725bac
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD36B SYNE1 SMCHD1 XRN1 ARAP2	4.19e-05	190	90	5	d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCell	Control-Endothelial-VE_Venous\|Control / Disease state, Lineage and Cell class	ZCWPW2 PTPRR SPTBN1 IL33 DOC2B	4.29e-05	191	90	5	617546cf4883dedf3323e03a53ba5adec334cf8e
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MLXIPL SNAP25 KCNB2 ADH1A PROX1	4.40e-05	192	90	5	5692bd57093852d442400383850f416c497dcc7d
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SP100 SLF1 SYNE1 SMCHD1 ARAP2	4.40e-05	192	90	5	ed1fb700d3e8f00495727d61e164fc0b70274fd0
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SP100 SLF1 SYNE1 SMCHD1 ARAP2	4.40e-05	192	90	5	6779b0294bb058e748e22b795b6a381c4add37e9
ToppCell	IPF-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	SLC12A2 SYNE1 SPTBN1 DAAM1 SIPA1L2	4.62e-05	194	90	5	777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	ZCWPW2 DNAH10 SYNE1 CFAP221 SPTBN1	4.74e-05	195	90	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	B_cells-ISG-high_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	PARP11 SMCHD1 XRN1 OAS2 TLR7	4.74e-05	195	90	5	b64d9e1a8834401b4dc501566546647754ae21fc
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	ZCWPW2 DNAH10 SYNE1 CFAP221 SPTBN1	4.74e-05	195	90	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD36B PTPRR SYNE1 SNAP25 KCNB2	4.85e-05	196	90	5	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Mild-CD8+_T_activated\|World / Disease group and Cell class	SP100 SMCHD1 XRN1 OAS2 ARAP2	4.85e-05	196	90	5	79632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	SP100 RACK1 SMCHD1 XRN1 OAS2	4.97e-05	197	90	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	systemic_lupus_erythematosus-flare\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SP100 SF3B1 SYNE1 SMCHD1 XRN1	5.09e-05	198	90	5	4c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	SP100 RACK1 SMCHD1 XRN1 OAS2	5.09e-05	198	90	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DDX19B DDX19A IGHG1 MROH2B ADH4	5.09e-05	198	90	5	24bc53bd8ef8f4f2f4fc377aeee75126ad5d311f
ToppCell	Mild-CD8+_T_activated\|Mild / Disease group and Cell class	SP100 SMCHD1 XRN1 OAS2 ARAP2	5.09e-05	198	90	5	ceac1b51bacfd0dd7fe7c6a666f7927055e1f380
ToppCell	CV-Mild-1\|CV / Virus stimulation, Condition and Cluster	PARP11 SP100 SMCHD1 XRN1 OAS2	5.09e-05	198	90	5	4b078714c49e7befb7b113d72485e712236d35fa
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SP100 RACK1 SMCHD1 XRN1 OAS2	5.09e-05	198	90	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	356C-Fibroblasts-Fibroblast-F\|356C / Donor, Lineage, Cell class and subclass (all cells)	MXRA5 SFRP2 ABCA6 TMEM45A IL33	5.22e-05	199	90	5	59fe5f3c6338e019a149ab135acf9cc5657298bf
ToppCell	356C-Fibroblasts-Fibroblast-F-\|356C / Donor, Lineage, Cell class and subclass (all cells)	MXRA5 SFRP2 ABCA6 TMEM45A IL33	5.22e-05	199	90	5	136f24597ddca5cf2175120975c94782a3232ec6
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SPTBN1 GRB10 SNAP25 IL33 DOC2B	5.22e-05	199	90	5	6fb81388c5045e81c3849a7136bdff3f953f044e
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SP100 SYNE1 SMCHD1 XRN1 ARAP2	5.34e-05	200	90	5	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	SLF1 SLC12A2 SMCHD1 SPTBN1 OAS2	5.34e-05	200	90	5	bcd1cc96197929d6011903803b6f4ccdcf52b4ce
ToppCell	Transverse-Dendritic_cell-cycling_DCs\|Dendritic_cell / Region, Cell class and subclass	OSBPL1A CKAP2L CKAP2 KIF20B CD209	5.34e-05	200	90	5	617a6a42f7b31eb3c45bdceaf55a591b6de7f154
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / Treatment groups by lineage, cell group, cell type	SLF1 SLC12A2 SPTBN1 OAS2 SIPA1L2	5.34e-05	200	90	5	b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SLF1 SLC12A2 SMCHD1 SPTBN1 OAS2	5.34e-05	200	90	5	a1fa6bae5a688faf488d6925cd3fad725dfa916b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Stem_cells\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	SFRP2 CKAP2L TP53I13 CKAP2 KIF20B	5.34e-05	200	90	5	008f137920cc3b599376706803c111d1d0ec17ef
ToppCell	LPS_IL1RA_TNF-Endothelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SLF1 SLC12A2 SMCHD1 SPTBN1 OAS2	5.34e-05	200	90	5	d01cec331be3b03cef80e9536fc531285bcf00f6
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	SLC12A2 SMCHD1 SPTBN1 OAS2 SIPA1L2	5.34e-05	200	90	5	be55cef682ba87250dad97689332c8820b3a7420
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Stem_cells-Neuroepithelial_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	SFRP2 CKAP2L TP53I13 CKAP2 KIF20B	5.34e-05	200	90	5	0e119c2742f2be19fde8890d1227bf277ead976f
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_venous\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SPTBN1 GRB10 SNAP25 IL33 DOC2B	5.34e-05	200	90	5	a3b09580738783c6bff31ea33d5188912e56b8a7
ToppCell	Endothelial-H_(cycle)\|World / shred on cell class and cell subclass (v4)	CKAP2L CKAP2 KIF20B DOC2B	1.53e-04	133	90	4	8e3005114761feee028c496cc739e607b35d7831
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIK3CD CKAP2L OAS2 KIF20B	1.97e-04	142	90	4	be63c48794a227ea55978524c0f5935342fc455e
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	ANKRD36B SLF1 SMCHD1 ARAP2	2.49e-04	151	90	4	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ANKRD13B PARP11 SNAP25 CKAP2	2.49e-04	151	90	4	c06a54afe918b14f885d6a85fbcf81e80f33afae
ToppCell	367C-Fibroblasts-Fibroblast-D-\|367C / Donor, Lineage, Cell class and subclass (all cells)	SFRP2 ABCA6 TMEM45A MROH2B	2.68e-04	154	90	4	dd3d34f065820e706515a13619f19a5b12734c8e
ToppCell	367C-Fibroblasts-Fibroblast-D\|367C / Donor, Lineage, Cell class and subclass (all cells)	SFRP2 ABCA6 TMEM45A MROH2B	2.68e-04	154	90	4	4bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCell	COVID-19_Moderate-multiplets\|World / disease group, cell group and cell class	ANKRD36B IGHG1 SYNE1 ARAP2	2.82e-04	156	90	4	afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-C_(Capillary_Aerocyte_)\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	MXRA5 SLC12A2 SYNE1 SIPA1L2	2.89e-04	157	90	4	84f629b7f589ca8a1abc220fa740c4a6fdc1b579
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D122\|Adult / Lineage, Cell type, age group and donor	MXRA5 ABCA6 IGHG1 KCNB2	2.96e-04	158	90	4	410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MLXIPL SLC12A2 CLTC MAGI3	3.25e-04	162	90	4	06f5d6c0bb26fe9d5180bc2ebf2c54bf52e715f3
ToppCell	368C-Fibroblasts-Fibroblast-E\|368C / Donor, Lineage, Cell class and subclass (all cells)	NLRP14 SFRP2 ERCC6 ABCA6	3.25e-04	162	90	4	e17632778a57c71d6005d3abca3a0443a92040e7
ToppCell	368C-Fibroblasts-Fibroblast-E-\|368C / Donor, Lineage, Cell class and subclass (all cells)	NLRP14 SFRP2 ERCC6 ABCA6	3.25e-04	162	90	4	ac4a80fd72c9311ea2b3e574c6284bbce4f2756c
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MLXIPL SLC12A2 CLTC MAGI3	3.25e-04	162	90	4	d0d9c18a73bc0bf4f38308ef2eee8ae20f6a7918
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	ANKRD36B SMCHD1 SPTBN1 ARAP2	3.25e-04	162	90	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	5'-Adult-Appendix-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	USP6 SLC12A2 SPTBN2 ADH1C	3.41e-04	164	90	4	29da0175bd3808a5b3039a6161c764105608ef96
ToppCell	5'-Adult-Appendix-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	USP6 SLC12A2 SPTBN2 ADH1C	3.41e-04	164	90	4	e83b632ac7e1dace946991ddfe1fbfbbffc3a88b
ToppCell	Adult-Epithelial-lung_goblet_cell-D175\|Adult / Lineage, Cell type, age group and donor	TMEM45A SPTBN2 IL33 DOC2B	3.41e-04	164	90	4	6e6aedb61f8e195d52e028fdda750a29bb14e57e
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DDX19B CKAP2L CKAP2 KIF20B	3.65e-04	167	90	4	d21635df8b74189e3309eaf435af381fbe412574
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCP11L1 CKAP2L CKAP2 SIPA1L2	3.73e-04	168	90	4	9b8a74abb83c64f0b5829dcb4275f722c82b45dc
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	OSBPL1A DDX25 XRN1 GRB10	3.73e-04	168	90	4	3fb79aaa858057c82645a90bd139fc4f096323c7
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIK3CD CKAP2L CKAP2 KIF20B	3.73e-04	168	90	4	52fd65024af8683db11d931f7563cbe8eb815d1c
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic-cDC1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCP11L1 CKAP2L CKAP2 SIPA1L2	3.73e-04	168	90	4	4b152b8d0f4a66faf664dfacb7914b18d60ce64a
ToppCell	PND14-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCP11L1 CKAP2L CKAP2 SIPA1L2	3.73e-04	168	90	4	c3169ad8f4130ef18777ed86770bb722ffb5db85
ToppCell	368C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	OSBPL1A DDX25 XRN1 GRB10	3.82e-04	169	90	4	0589f39d8e9468e42d25d30ff70bb7cb8b921628
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKAP2L CKAP2 KIF20B ADH1A	3.82e-04	169	90	4	563c267edaade0e5df192ad953801ef9768d4270
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DDX25 SNAP25 KCNB2 DSCAML1	3.82e-04	169	90	4	b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKAP2L CKAP2 NCOA4 KIF20B	3.90e-04	170	90	4	e08a6c5ac34c456da8c7318f104e06fca585be1f
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8\|TCGA-Liver / Sample_Type by Project: Shred V9	TDRD15 PRAMEF33 PRAMEF10 SPTBN2	3.99e-04	171	90	4	c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SYNE1 SMCHD1 ARIH1 ARAP2	3.99e-04	171	90	4	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P1-Tnr-Polydendrocyte.Tnr.Pdgfa-Pik3r3_(Pdgfa)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MROH2B CKAP2 FAM110C	4.01e-04	71	90	3	2220e1b02baa71961cfc85536bafeb313e588bf3
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P1-Tnr-Polydendrocyte.Tnr.Pdgfa-Pik3r3_(Pdgfa)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MROH2B CKAP2 FAM110C	4.01e-04	71	90	3	cc5de8bbcfefa2bf93cc137c74b49a745d5da229
ToppCell	Endothelial-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	ANKRD36B IL33 PROX1 DOC2B	4.08e-04	172	90	4	d4e98ff9c7cbc95457e1d71fa60f151a2f178dae
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKAP2L CKAP2 KIF20B ADH1A	4.08e-04	172	90	4	c06ca5d075937747952ed915c9db39a9f62072f9
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CKAP2L CKAP2 KIF20B ADH1A	4.08e-04	172	90	4	29c8510f26527d487d0fc3543102d067cdb281a6
ToppCell	Control-Endothelial_cells-Systemic_venous_endothelial_cells\|Control / group, cell type (main and fine annotations)	GRB10 SNAP25 IL33 DOC2B	4.08e-04	172	90	4	c55dce1ed3ed7312394b4e050e1de852a994e130
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SP100 CLTC OAS2 TLR7	4.08e-04	172	90	4	714172f31abd0d25261df6115ec6a9df491fa14b
ToppCell	droplet-Marrow-nan-24m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SESTD1 ABCA6 DNAH17 TMED8	4.17e-04	173	90	4	6d2ceba4f89a228600e2b40aba81bb0eb81578c0
Computational	Genes in the cancer module 514.	ADH1A ADH1C ADH4	1.74e-05	10	58	3	MODULE_514
Computational	Oxidoreductases.	ADH1A ADH1C ADH4	2.13e-04	22	58	3	MODULE_373
Drug	N-heptylformamide	ADH1A ADH1C ADH4	3.08e-06	8	88	3	CID000347402
Drug	2-NA	ADH1A ADH1C ADH4	4.61e-06	9	88	3	CID000074128
Drug	(3R,7R)-17-(6-hydroxy-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol	ADH1A ADH1C ADH4	4.61e-06	9	88	3	CID000440672
Drug	AC1L1J0I	ADH1A ADH1C ADH4	1.20e-05	12	88	3	CID000030201
Drug	hexa-2,4-dien-1-ol	ADH1A ADH1C ADH4	1.20e-05	12	88	3	CID000008104
Drug	Ethylene Glycols	ADH1C ADH4	1.48e-05	2	88	2	ctd:D005026
Drug	Cyclohexylformamide	ADH1C ADH4	1.48e-05	2	88	2	DB03559
Drug	2-naphthaldehyde	ADH1A ADH1C ADH4	1.55e-05	13	88	3	CID000006201
Drug	naphthalenemethanol	ADH1A ADH1C ADH4	1.97e-05	14	88	3	CID000020908
Drug	6-[(3R,7R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptanal	ADH1A ADH1C ADH4	2.45e-05	15	88	3	CID000440673
Drug	phenoxyethanol	ADH1A ADH1C ADH4	3.01e-05	16	88	3	CID000031236
Drug	naphthaldehyde	ADH1A ADH1C ADH4	3.01e-05	16	88	3	CID000006195
Drug	6-propionyl-2-(dimethylamino)naphthalene	NLRP14 SPTBN1 SPTBN2	3.01e-05	16	88	3	CID000107729
Drug	4-Iodopyrazole	ADH1A ADH1C	4.42e-05	3	88	2	DB02721
Drug	BMS-214662	DDX19B NLRP14 XRN1 ADH1A	4.90e-05	52	88	4	CID000448545
Drug	C x F	ADH1A ADH1C ADH4	5.17e-05	19	88	3	CID000013017
Drug	lariat	DDX19B NLRP14 SF3B1 SEC62 XRN1	5.48e-05	105	88	5	CID000165706
Drug	Ethylene Glycol	ADH1A ADH1C ADH4	7.06e-05	21	88	3	ctd:D019855
Disease	fish oil supplement exposure measurement, low density lipoprotein cholesterol measurement	MLXIPL ABCA6	4.90e-05	4	85	2	EFO_0004611, EFO_0600007
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTBN1 SPTBN2	4.90e-05	4	85	2	DOID:0050882 (implicated_via_orthology)
Disease	IGF-1 measurement	MLXIPL SPTBN2 SETD4 RPL3L MAPK8IP3 ADH1A PROX1 ADH1C	8.35e-05	488	85	8	EFO_0004627
Disease	cerebrospinal fluid clusterin measurement	SETD5 MAGI3 ADH1C	1.41e-04	35	85	3	EFO_0007657
Disease	Colorectal Carcinoma	SFRP2 ERCC6 STRAP ABCA6 SYNE1 SPTBN2 SETD4 KCNB2 DSCAML1	1.91e-04	702	85	9	C0009402
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	TDRD15 MLXIPL ABCA6 KCNB2 TANGO6 ADH4	2.47e-04	303	85	6	EFO_0004612, EFO_0020945
Disease	cholesteryl ester measurement, high density lipoprotein cholesterol measurement	TDRD15 MLXIPL DNAH10 KCNB2 TANGO6 ADH4	2.89e-04	312	85	6	EFO_0004612, EFO_0010351
Disease	cholesterol to total lipids in large VLDL percentage	TDRD15 MLXIPL ABCA6	3.00e-04	45	85	3	EFO_0022236
Disease	total cholesterol measurement, high density lipoprotein cholesterol measurement	TDRD15 MLXIPL DNAH10 KCNB2 TANGO6 ADH4	3.04e-04	315	85	6	EFO_0004574, EFO_0004612
Disease	lipoprotein A measurement	TDRD15 ABCA6 DSCAML1 ADH1C	3.14e-04	112	85	4	EFO_0006925
Disease	cholesteryl esters to total lipids in small VLDL percentage	TDRD15 MLXIPL ABCA6	3.86e-04	49	85	3	EFO_0022256
Disease	cholesterol to total lipids in small VLDL percentage	TDRD15 MLXIPL ABCA6	4.35e-04	51	85	3	EFO_0022242
Disease	tuberculosis (is_marker_for)	IL33 CD209	4.44e-04	11	85	2	DOID:399 (is_marker_for)
Disease	triglycerides to total lipids in very large VLDL percentage	TDRD15 MLXIPL ABCA6	4.87e-04	53	85	3	EFO_0022340
Disease	cholesteryl esters to total lipids in very large VLDL percentage	TDRD15 MLXIPL ABCA6	4.87e-04	53	85	3	EFO_0022258
Disease	cholesterol to total lipids in very large VLDL percentage	TDRD15 MLXIPL ABCA6	5.15e-04	54	85	3	EFO_0022244
Disease	beta wave measurement	OSBPL1A RGS21	5.31e-04	12	85	2	EFO_0006871
Disease	triglycerides in medium VLDL measurement	TDRD15 MLXIPL DNAH10	5.43e-04	55	85	3	EFO_0022155
Disease	alcohol dependence measurement	ADH1A ADH1C ADH4	5.43e-04	55	85	3	EFO_0007835
Disease	free cholesterol to total lipids in large HDL percentage	TDRD15 MLXIPL ABCA6	5.73e-04	56	85	3	EFO_0022279
Disease	cholesteryl esters to total lipids in large VLDL percentage	TDRD15 MLXIPL ABCA6	5.73e-04	56	85	3	EFO_0022250
Disease	free cholesterol to total lipids in medium VLDL percentage	TDRD15 MLXIPL ABCA6	6.03e-04	57	85	3	EFO_0022284
Disease	triglycerides to total lipids in small VLDL percentage	TDRD15 MLXIPL ABCA6	6.35e-04	58	85	3	EFO_0022338
Disease	cholesterol in IDL measurement	TDRD15 MLXIPL ABCA6	6.35e-04	58	85	3	EFO_0021899
Disease	free cholesterol to total lipids in very large VLDL percentage	TDRD15 MLXIPL ABCA6	6.68e-04	59	85	3	EFO_0022289
Disease	triglycerides in small VLDL measurement	TDRD15 MLXIPL DNAH10	7.36e-04	61	85	3	EFO_0022145
Disease	free cholesterol in IDL measurement	TDRD15 MLXIPL ABCA6	7.36e-04	61	85	3	EFO_0022181
Disease	free cholesterol in very large VLDL measurement	TDRD15 MLXIPL DNAH10	7.36e-04	61	85	3	EFO_0022274
Disease	phospholipids in large VLDL measurement	TDRD15 MLXIPL DNAH10	7.72e-04	62	85	3	EFO_0022169
Disease	phospholipids in very large VLDL measurement	TDRD15 MLXIPL DNAH10	7.72e-04	62	85	3	EFO_0022299
Disease	triglycerides to total lipids in medium VLDL percentage	TDRD15 MLXIPL ABCA6	8.09e-04	63	85	3	EFO_0022335
Disease	cholesterol to total lipids in medium VLDL percentage	TDRD15 MLXIPL ABCA6	8.09e-04	63	85	3	EFO_0022239
Disease	cholesteryl esters to total lipids in medium VLDL percentage	TDRD15 MLXIPL ABCA6	8.47e-04	64	85	3	EFO_0022253
Disease	alcohol consumption measurement	MLXIPL SPTBN1 XRN1 MAGI3 ZSWIM2 MAP3K7 ARAP2 TANGO6 ADH1A ADH1C ADH4	8.64e-04	1242	85	11	EFO_0007878
Disease	cholesterol in large VLDL measurement	TDRD15 MLXIPL DNAH10	8.86e-04	65	85	3	EFO_0021902
Disease	cholesterol in very large VLDL measurement	TDRD15 MLXIPL DNAH10	8.86e-04	65	85	3	EFO_0022230
Disease	very low density lipoprotein cholesterol measurement	TDRD15 MLXIPL DNAH10 ABCA6 DSCAML1	9.44e-04	260	85	5	EFO_0008317
Disease	total lipids in small VLDL	TDRD15 MLXIPL DNAH10	9.67e-04	67	85	3	EFO_0022148
Disease	total lipids in large VLDL	TDRD15 MLXIPL DNAH10	9.67e-04	67	85	3	EFO_0022175
Disease	hearing loss	MLXIPL SPTBN1 GRB10	9.67e-04	67	85	3	EFO_0004238
Disease	free cholesterol in large VLDL measurement	TDRD15 MLXIPL DNAH10	1.01e-03	68	85	3	EFO_0022265
Disease	low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	TDRD15 MLXIPL IGHG1 TANGO6	1.02e-03	153	85	4	EFO_0004611, EFO_0020946
Disease	brain measurement, neuroimaging measurement	SFRP2 SLF1 SPTBN1 GRB10 MAP3K7 DSCAML1 TANGO6	1.06e-03	550	85	7	EFO_0004346, EFO_0004464
Disease	Alcoholic Intoxication, Chronic	RACK1 DSCAML1 ADH1A ADH1C ADH4	1.08e-03	268	85	5	C0001973
Disease	unipolar depression, alcohol dependence	GRB10 MAP3K7 ADH1A	1.50e-03	78	85	3	EFO_0003761, MONDO_0007079
Disease	colorectal carcinoma (is_implicated_in)	ERCC6 STRAP	1.82e-03	22	85	2	DOID:0080199 (is_implicated_in)
Disease	blood pressure	SYNE1 RGS21	1.82e-03	22	85	2	EFO_0004325
Disease	lipoprotein measurement, phospholipid measurement	TDRD15 MLXIPL ABCA6	1.92e-03	85	85	3	EFO_0004639, EFO_0004732
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	TDRD15 MLXIPL ABCA6 KCNB2 ADH4	1.96e-03	307	85	5	EFO_0004612, EFO_0020946
Disease	Carcinoma of lung	MXRA5 ERCC6	1.99e-03	23	85	2	C0684249
Disease	alcohol use disorder measurement, alcohol dependence	ADH1C ADH4	2.17e-03	24	85	2	EFO_0009458, MONDO_0007079
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	TDRD15 MLXIPL DNAH10 ABCA6 ADH4	2.19e-03	315	85	5	EFO_0004612, EFO_0008591
Disease	lipid measurement, lipoprotein measurement	TDRD15 MLXIPL ABCA6	2.26e-03	90	85	3	EFO_0004529, EFO_0004732
Disease	C-reactive protein measurement	TDRD15 MLXIPL SFRP2 ABCA6 SETD5 DNAH17 SETD4 KCNB2 MAPK8IP3 ADH1C	2.43e-03	1206	85	10	EFO_0004458
Disease	lipid measurement, high density lipoprotein cholesterol measurement	TDRD15 MLXIPL DNAH10 TANGO6 ADH4	2.68e-03	330	85	5	EFO_0004529, EFO_0004612
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	TDRD15 MLXIPL DNAH10 ABCA6	2.70e-03	200	85	4	EFO_0004611, EFO_0020945
Disease	Agouti-related protein measurement	ABCA6 TANGO6	2.75e-03	27	85	2	EFO_0008016

Protein segments in the cluster

Peptide	Gene	Start	Entry
EVWKKCSLNKTGKFA	PRAMEF33	211	A0A0G2JMD5
SLNKEWKKKYVTLCD	AGAP3	381	Q96P47
KVIKCKAAVLWELKK	ADH1A	6	P07327
KVIKCKAAIAWEAGK	ADH4	6	P08319
KVIKCKAAVLWELKK	ADH1C	6	P00326
QTKALLCKNFLKKWR	ABCA6	11	Q8N139
SEKKLLEETNKKWCV	ARAP2	911	Q8WZ64
KNTFCLWKRLIKLKD	ANKRD36B	811	Q8N2N9
DDKCNLAKFWICKKS	CD209	366	Q9NNX6
VLDWCFKLKLIDLTK	DDX25	226	Q9UHL0
DAKKLVKYWICLALI	CKAP2	456	Q8WWK9
KQRKKKAWIYCESLS	TP53I13	136	Q8NBR0
DKLVKVWNLANCKLK	RACK1	171	P63244
KCKWLKKWIKKCDDD	ARIH1	316	Q9Y4X5
LTTKTQKFKAKLWLC	ANKRD13B	361	Q86YJ7
TKILCKWKKADLTVQ	ERCC6	576	P0DP91
DKIDKWDLIKLKSFC	nan	1006	O00370
KKKKHWLSKVQECAV	MAGI3	6	Q5TCQ9
VANWKKCLHSIKLKD	MAPK8IP3	986	Q9UPT6
CWKAAQIKEHLLKSK	EIF2B5	96	Q13144
WEECKEIVKASSKKS	KIF20B	1061	Q96Q89
CKAKWRAKDVAIKQI	MAP3K7	51	O43318
VDLKLAKLKLCTEFW	NRDE2	381	Q9H7Z3
TGDKLKFCLFTKWLK	OAS2	101	P29728
QDKSKKKLCALYGKW	OSBPL1A	761	Q9BXW6
ITKLKEKNEKCVLYW	PTPRR	491	Q15256
NCEKEALYKWLLKKE	NCOA4	421	Q13772
DLWEFFCRKKAQLKK	PARP11	176	Q9NR21
ALPAEKKWQIYCSKK	DAAM1	76	Q9Y4D1
KWKNTASKALCFKLG	IL33	16	O95760
CCPDKRKKLWDLLEK	KCNB2	171	Q92953
LKHWFDCLKNKDKRI	DOC2B	381	Q14184
NLKTKEKAAKWILAA	DNAH17	4441	Q9UFH2
KLDSLKCGTWYKVKL	DSCAML1	1441	Q8TD84
KCGTWYKVKLAAKNS	DSCAML1	1446	Q8TD84
VLDWCSKLKFIDPKK	DDX19B	221	Q9UMR2
ELGKKSWKKLYVCLR	GRB10	301	Q13322
WLNGKEYKCKVSNKA	IGHG1	196	P01857
LDWCSKLKFIDPKKI	DDX19A	221	Q9NUU7
KNKKWKKQDLCLGST	HHIPL2	536	Q6UWX4
SLEKSKRKKPCAWLS	DNAH10	3756	Q8IVF4
ARIIKWLYTCKKAKE	FAM110C	291	Q1W6H9
WVKQRKDLLHLCCKK	PRAMEF26	76	H0Y7S4
KKWSKKFIDFIDTCL	MINK1	256	Q8N4C8
LKKELTEEWQKACAK	CFAP221	391	Q4G0U5
CIKLWSLRSKKLKSE	TAF5L	291	O75529
KKRVKEIVHKAFWDC	TCP11L1	101	Q9NUJ3
WLACEDFKKTKNADK	RGS21	51	Q2M5E4
DLKKSVLWLKDSLQC	SFRP2	231	Q96HF1
LWLKDCHEKYDKQIK	SMCHD1	561	A6NHR9
CWLKDKAKQIAQKDV	SYNE1	2036	Q8NF91
KKLAFLLKDWEKCEK	SYNE1	7666	Q8NF91
CVINELLKWKACSKL	TDRD15	1461	B5MCY1
LLKWKACSKLQKSAL	TDRD15	1466	B5MCY1
DWHKSKKKAFTKACK	RPL3L	121	Q92901
KNACKLKAILSKWLE	POU1F1	181	P28069
WKKAIYKVICKLDSE	PROX1	706	Q92786
KKDCSKELTCKALWE	SIPA1L2	86	Q9P2F8
KLLCLEAEKFTCWKK	SETD4	346	Q9NVD3
CKDNADLLSPLKKWK	SETD5	821	Q9C0A6
YCVWIQKVKSKKLAA	SHQ1	386	Q6PI26
EKKFLWKALGTTLAC	MROH2B	611	Q7Z745
ELKKHNKKDDCWICI	CYB5R4	61	Q7L1T6
WKNFKGLKLLCRDKI	MLXIPL	106	Q9NP71
IKKALWCSEDKQILS	STRAP	146	Q9Y3F4
PCNKLKSSDAYKKAW	SNAP25	91	P60880
KKVTHFCFWKEKDRL	SESTD1	106	Q86VW0
EKKSAKDALLLWCQM	SPTBN1	171	Q01082
WKQSVELCKKDSLYK	CLTC	1521	Q00610
AEKFAKFWICKAKLL	CKAP2L	551	Q8IYA6
KFWICKAKLLASKGT	CKAP2L	556	Q8IYA6
SVALKKKAKCLLSKW	TCEANC	61	Q8N8B7
KKAKCLLSKWKAVYK	TCEANC	66	Q8N8B7
KAVDCLLDSKWAKAK	SEC62	51	Q99442
KSAKDALLLWCQMKT	SPTBN2	176	O15020
PFLKAVCKSKKSWQA	SF3B1	646	O75533
KKTKSESWKCDICKK	ZBTB41	456	Q5SVQ8
YLLTTKKKWKDCKIR	SLC12A2	1041	P55011
LKKCSETWKTIFAKE	SP100	716	P23497
EKKKLKGQENSLCWT	XRN1	386	Q8IZH2
DWKKCDLIAKILASC	TANGO6	346	Q9C0B7
CWKKLKTTTFNDKID	TTC3	691	P53804
STKKKSKKADCPIAW	PIK3CD	406	O00329
EVWKKCSLNKTGKFA	PRAMEF10	211	O60809
KKWECLKSIKAHKGQ	PAK1IP1	111	Q9NWT1
GLKSFSWKKLQCLKN	TLR7	686	Q9NYK1
CKRKNILEWAKELSL	RWDD2B	201	P57060
KFLAACAAGKWILTK	SLF1	56	Q9BQI6
CKHICWVLLKKFKLP	ZSWIM2	76	Q8NEG5
DKQKWCDVCKKLVDL	TTC37	111	Q6PGP7
KKKWYKSALQEACLL	ZCWPW2	171	Q504Y3
WCTKSILKYICKKQK	TMEM45A	21	Q9NWC5
NTLKLWDYSKGKCLK	WDR5	236	P61964
KCKTHCLATKKLDLW	USP6	1056	P35125
CIWTFAKVKEFKSKL	TMED8	161	Q6PL24
KEKFCITWDKKSLAG	NLRP14	131	Q86W24
WDAKSRGILKCKKDK	MXRA5	231	Q9NR99