Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Toll-like receptor 2 binding	TLR6 TLR1	1.79e-05	4	35	2	GO:0035663
GeneOntologyMolecularFunction	lipopeptide binding	TLR6 TLR1	1.33e-04	10	35	2	GO:0071723
GeneOntologyMolecularFunction	NAD+ nucleotidase, cyclic ADP-ribose generating	TLR6 TLR1	3.53e-04	16	35	2	GO:0061809
GeneOntologyMolecularFunction	potassium ion leak channel activity	KCNK3 KCNK15	3.53e-04	16	35	2	GO:0022841
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	ADGRL1 TAAR1 ADGRG3 GRIN2B TLR6 GALR3 OR51B2 GPR45 TLR1	4.14e-04	1353	35	9	GO:0004888
GeneOntologyMolecularFunction	narrow pore channel activity	KCNK3 KCNK15	5.01e-04	19	35	2	GO:0022842
GeneOntologyMolecularFunction	leak channel activity	KCNK3 KCNK15	5.01e-04	19	35	2	GO:0022840
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCNK3 KCNK15	1.02e-03	27	35	2	GO:0015271
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM2B KDM6B	1.10e-03	28	35	2	GO:0141052
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNK3 TMEM120B GRIN2B TRPC1 KCNK15	1.15e-03	459	35	5	GO:0005216
GeneOntologyMolecularFunction	Toll-like receptor binding	TLR6 TLR1	1.18e-03	29	35	2	GO:0035325
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	KCNK3 SLC17A2 GRIN2B TRPC1 KCNK15	1.22e-03	465	35	5	GO:0046873
GeneOntologyMolecularFunction	histone demethylase activity	KDM2B KDM6B	1.34e-03	31	35	2	GO:0032452
GeneOntologyMolecularFunction	acylglycerol O-acyltransferase activity	MBOAT1 DGAT1	1.43e-03	32	35	2	GO:0016411
GeneOntologyMolecularFunction	protein demethylase activity	KDM2B KDM6B	1.43e-03	32	35	2	GO:0140457
GeneOntologyMolecularFunction	amide binding	GRIN2B TLR6 GALR3 TLR1	1.79e-03	299	35	4	GO:0033218
GeneOntologyMolecularFunction	channel activity	KCNK3 TMEM120B GRIN2B TRPC1 KCNK15	2.08e-03	525	35	5	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	KCNK3 TMEM120B GRIN2B TRPC1 KCNK15	2.10e-03	526	35	5	GO:0022803
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	KCNK3 SLC17A2 TMEM120B GRIN2B TRPC1 KCNK15	2.33e-03	793	35	6	GO:0015075
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing N-glycosyl compounds	TLR6 TLR1	2.34e-03	41	35	2	GO:0016799
GeneOntologyMolecularFunction	demethylase activity	KDM2B KDM6B	2.70e-03	44	35	2	GO:0032451
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNK3 GRIN2B TRPC1 KCNK15	2.94e-03	343	35	4	GO:0005261
GeneOntologyMolecularFunction	transmembrane transporter activity	KCNK3 SLC17A2 TMEM120B GRIN2B SV2B TRPC1 KCNK15	3.87e-03	1180	35	7	GO:0022857
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	KCNK3 GRIN2B KCNK15	3.93e-03	182	35	3	GO:0005244
GeneOntologyMolecularFunction	G protein-coupled receptor activity	ADGRL1 TAAR1 ADGRG3 GALR3 OR51B2 GPR45	4.00e-03	884	35	6	GO:0004930
GeneOntologyMolecularFunction	voltage-gated channel activity	KCNK3 GRIN2B KCNK15	4.06e-03	184	35	3	GO:0022832
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	KCNK3 SLC17A2 GRIN2B TRPC1 KCNK15	4.47e-03	627	35	5	GO:0022890
GeneOntologyMolecularFunction	O-acyltransferase activity	MBOAT1 DGAT1	4.80e-03	59	35	2	GO:0008374
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	KCNK3 SLC17A2 GRIN2B TRPC1 KCNK15	5.69e-03	664	35	5	GO:0008324
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM2B KDM6B	5.79e-03	65	35	2	GO:0016706
GeneOntologyMolecularFunction	transporter activity	KCNK3 SLC17A2 TMEM120B GRIN2B SV2B TRPC1 KCNK15	6.26e-03	1289	35	7	GO:0005215
GeneOntologyMolecularFunction	promoter-specific chromatin binding	L3MBTL2 RBL2	9.29e-03	83	35	2	GO:1990841
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	KCNK3 SLC17A2 GRIN2B TRPC1 KCNK15	9.82e-03	758	35	5	GO:0015318
GeneOntologyMolecularFunction	methylated histone binding	L3MBTL1 L3MBTL2	9.95e-03	86	35	2	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	L3MBTL1 L3MBTL2	1.04e-02	88	35	2	GO:0140034
GeneOntologyMolecularFunction	dioxygenase activity	KDM2B KDM6B	1.28e-02	98	35	2	GO:0051213
GeneOntologyMolecularFunction	amyloid-beta binding	GRIN2B TLR6	1.38e-02	102	35	2	GO:0001540
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	KCNK3 KCNK15	1.38e-02	102	35	2	GO:0005249
GeneOntologyBiologicalProcess	detection of bacterial lipopeptide	TLR6 TLR1	8.38e-06	3	35	2	GO:0070340
GeneOntologyBiologicalProcess	detection of bacterial lipoprotein	TLR6 TLR1	1.67e-05	4	35	2	GO:0042494
GeneOntologyBiologicalProcess	cellular response to bacterial lipoprotein	TLR6 TLR1	1.25e-04	10	35	2	GO:0071220
GeneOntologyBiologicalProcess	cellular response to bacterial lipopeptide	TLR6 TLR1	1.25e-04	10	35	2	GO:0071221
GeneOntologyBiologicalProcess	response to bacterial lipopeptide	TLR6 TLR1	1.25e-04	10	35	2	GO:0070339
GeneOntologyBiologicalProcess	response to bacterial lipoprotein	TLR6 TLR1	1.52e-04	11	35	2	GO:0032493
GeneOntologyBiologicalProcess	regulation of toll-like receptor 2 signaling pathway	TLR6 TLR1	2.16e-04	13	35	2	GO:0034135
GeneOntologyBiologicalProcess	detection of molecule of bacterial origin	TLR6 TLR1	3.31e-04	16	35	2	GO:0032490
GeneOntologyBiologicalProcess	stabilization of membrane potential	KCNK3 KCNK15	3.74e-04	17	35	2	GO:0030322
GeneOntologyBiologicalProcess	activation of NF-kappaB-inducing kinase activity	TLR6 TLR1	3.74e-04	17	35	2	GO:0007250
GeneOntologyBiologicalProcess	regulation of cytosolic calcium ion concentration	GRIN2B SV2B TRPC1	3.88e-04	84	35	3	GO:0051480
GeneOntologyBiologicalProcess	toll-like receptor 2 signaling pathway	TLR6 TLR1	4.70e-04	19	35	2	GO:0034134
GeneOntologyBiologicalProcess	detection of bacterium	TLR6 TLR1	5.21e-04	20	35	2	GO:0016045
GeneOntologyCellularComponent	phagocytic vesicle membrane	CYBB TLR6 TLR1	3.60e-04	83	35	3	GO:0030670
GeneOntologyCellularComponent	specific granule membrane	CYBB ADGRG3 DGAT1	4.72e-04	91	35	3	GO:0035579
Domain	Toll-like_receptor	TLR6 TLR1	3.21e-05	5	34	2	IPR017241
Domain	MBT	L3MBTL1 L3MBTL2	1.15e-04	9	34	2	SM00561
Domain	MBT	L3MBTL1 L3MBTL2	1.15e-04	9	34	2	PS51079
Domain	2pore_dom_K_chnl_TASK	KCNK3 KCNK15	1.15e-04	9	34	2	IPR003092
Domain	MBT	L3MBTL1 L3MBTL2	1.43e-04	10	34	2	PF02820
Domain	Mbt	L3MBTL1 L3MBTL2	1.43e-04	10	34	2	IPR004092
Domain	MBOAT_fam	MBOAT1 DGAT1	1.75e-04	11	34	2	IPR004299
Domain	MBOAT	MBOAT1 DGAT1	1.75e-04	11	34	2	PF03062
Domain	2pore_dom_K_chnl	KCNK3 KCNK15	3.33e-04	15	34	2	IPR003280
Domain	K_chnl_dom	KCNK3 KCNK15	6.61e-04	21	34	2	IPR013099
Domain	Ion_trans_2	KCNK3 KCNK15	6.61e-04	21	34	2	PF07885
Domain	TIR	TLR6 TLR1	6.61e-04	21	34	2	SM00255
Domain	TIR	TLR6 TLR1	7.26e-04	22	34	2	PF01582
Domain	-	TLR6 TLR1	7.95e-04	23	34	2	3.40.50.10140
Domain	JmjC	KDM2B KDM6B	8.66e-04	24	34	2	PF02373
Domain	TIR	TLR6 TLR1	8.66e-04	24	34	2	PS50104
Domain	TIR_dom	TLR6 TLR1	9.40e-04	25	34	2	IPR000157
Domain	Plexin_repeat	SEMA6B MEGF8	1.54e-03	32	34	2	IPR002165
Domain	LRRCT	TLR6 TLR1	1.54e-03	32	34	2	PF01463
Domain	PSI	SEMA6B MEGF8	1.54e-03	32	34	2	PF01437
Domain	JMJC	KDM2B KDM6B	1.54e-03	32	34	2	PS51184
Domain	JmjC_dom	KDM2B KDM6B	1.54e-03	32	34	2	IPR003347
Domain	JmjC	KDM2B KDM6B	1.64e-03	33	34	2	SM00558
Domain	GPS	ADGRL1 ADGRG3	1.74e-03	34	34	2	SM00303
Domain	GPS	ADGRL1 ADGRG3	1.84e-03	35	34	2	PF01825
Domain	GPS	ADGRL1 ADGRG3	1.95e-03	36	34	2	PS50221
Domain	GPS	ADGRL1 ADGRG3	2.06e-03	37	34	2	IPR000203
Domain	G_PROTEIN_RECEP_F2_1	ADGRL1 ADGRG3	2.40e-03	40	34	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	ADGRL1 ADGRG3	2.40e-03	40	34	2	PS50227
Domain	GPCR_2_extracellular_dom	ADGRL1 ADGRG3	2.40e-03	40	34	2	IPR001879
Domain	PSI	SEMA6B MEGF8	2.90e-03	44	34	2	IPR016201
Domain	PSI	SEMA6B MEGF8	3.17e-03	46	34	2	SM00423
Domain	G_PROTEIN_RECEP_F2_2	ADGRL1 ADGRG3	3.73e-03	50	34	2	PS00650
Domain	7tm_2	ADGRL1 ADGRG3	3.73e-03	50	34	2	PF00002
Domain	GPCR_2-like	ADGRL1 ADGRG3	5.33e-03	60	34	2	IPR017981
Domain	GPCR_2_secretin-like	ADGRL1 ADGRG3	5.33e-03	60	34	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	ADGRL1 ADGRG3	5.50e-03	61	34	2	PS50261
Domain	MFS	SLC17A2 SV2B	8.64e-03	77	34	2	IPR011701
Domain	MFS_1	SLC17A2 SV2B	8.64e-03	77	34	2	PF07690
Pathway	WP_MYD88_DISTINCT_INPUTOUTPUT_PATHWAY	TLR6 TLR1	5.71e-04	18	28	2	M39478
Pathway	REACTOME_IRAK4_DEFICIENCY_TLR2_4	TLR6 TLR1	5.71e-04	18	28	2	M27464
Pathway	REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL	KCNK3 KCNK15	6.37e-04	19	28	2	M27452
Pathway	REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL	KCNK3 KCNK15	6.37e-04	19	28	2	MM15194
Pathway	REACTOME_REGULATION_OF_TLR_BY_ENDOGENOUS_LIGAND	TLR6 TLR1	8.57e-04	22	28	2	M27571
Pathway	REACTOME_REGULATION_OF_TLR_BY_ENDOGENOUS_LIGAND	TLR6 TLR1	8.57e-04	22	28	2	MM15284
Pathway	PID_TOLL_ENDOGENOUS_PATHWAY	TLR6 TLR1	1.02e-03	24	28	2	M264
Pathway	REACTOME_CARDIAC_CONDUCTION	KCNK3 TRPC1 KCNK15	1.09e-03	103	28	3	MM15196
Pathway	REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION	CYBB TLR6 TLR1	1.18e-03	106	28	3	M518
Pubmed	Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.	TLR6 TLR1	9.84e-07	2	35	2	22315281
Pubmed	Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.	TLR6 TLR1	9.84e-07	2	35	2	18036178
Pubmed	TASK-5, a novel member of the tandem pore K+ channel family.	KCNK3 KCNK15	9.84e-07	2	35	2	11680614
Pubmed	The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy.	TLR6 TLR1	9.84e-07	2	35	2	24445834
Pubmed	The Roles of TLR Gene Polymorphisms in Atherosclerosis: A Systematic Review and Meta-Analysis of 35,317 Subjects.	TLR6 TLR1	9.84e-07	2	35	2	28474755
Pubmed	[DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS].	TLR6 TLR1	9.84e-07	2	35	2	26470427
Pubmed	Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.	TLR6 TLR1	9.84e-07	2	35	2	21852947
Pubmed	Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).	TLR6 TLR1	9.84e-07	2	35	2	24984237
Pubmed	Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function.	KDM2B L3MBTL2	9.84e-07	2	35	2	29166607
Pubmed	A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.	TLR6 TLR1	9.84e-07	2	35	2	22778390
Pubmed	Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.	TLR6 TLR1	9.84e-07	2	35	2	11123271
Pubmed	SNPs in the exons of Toll-like receptors are associated with susceptibility to type 1 diabetes in Chinese population.	TLR6 TLR1	9.84e-07	2	35	2	25261617
Pubmed	Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.	TLR6 TLR1	9.84e-07	2	35	2	29175392
Pubmed	Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.	TLR6 TLR1	2.95e-06	3	35	2	19931471
Pubmed	Divergent roles of amino acid residues inside and outside the BB loop affect human Toll-like receptor (TLR)2/2, TLR2/1 and TLR2/6 responsiveness.	TLR6 TLR1	2.95e-06	3	35	2	23626692
Pubmed	Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk.	TLR6 TLR1	2.95e-06	3	35	2	15812078
Pubmed	Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.	TLR6 TLR1	2.95e-06	3	35	2	16081826
Pubmed	Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.	TLR6 TLR1	2.95e-06	3	35	2	28123183
Pubmed	Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.	TLR6 TLR1	2.95e-06	3	35	2	18752252
Pubmed	Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists.	TLR6 TLR1	2.95e-06	3	35	2	22822027
Pubmed	Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.	TLR6 TLR1	2.95e-06	3	35	2	25028161
Pubmed	Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs.	TLR6 TLR1	2.95e-06	3	35	2	15731092
Pubmed	Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors.	TLR6 TLR1	2.95e-06	3	35	2	25246533
Pubmed	TLR1, TLR2, and TLR6 gene polymorphisms are associated with increased susceptibility to complicated skin and skin structure infections.	TLR6 TLR1	2.95e-06	3	35	2	24511099
Pubmed	The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.	TLR6 TLR1	2.95e-06	3	35	2	11095740
Pubmed	Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.	TLR6 TLR1	2.95e-06	3	35	2	18091991
Pubmed	TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation.	TLR6 TLR1	2.95e-06	3	35	2	16461792
Pubmed	Toll-like receptor 2 subfamily gene polymorphisms are associated with Bacillus Calmette-Guérin osteitis following newborn vaccination.	TLR6 TLR1	2.95e-06	3	35	2	25605403
Pubmed	Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.	TLR6 TLR1	2.95e-06	3	35	2	14966134
Pubmed	Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer.	TLR6 TLR1	2.95e-06	3	35	2	17932345
Pubmed	Toll-like receptor 2 subfamily genotypes are not associated with severity of bronchiolitis or postbronchiolitis wheezing in infants.	TLR6 TLR1	2.95e-06	3	35	2	24112285
Pubmed	IFNs activate toll-like receptor gene expression in viral infections.	TLR6 TLR1	2.95e-06	3	35	2	11607792
Pubmed	Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses.	TLR6 TLR1	2.95e-06	3	35	2	23151486
Pubmed	[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].	TLR6 TLR1	2.95e-06	3	35	2	25850295
Pubmed	Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.	TLR6 TLR1	2.95e-06	3	35	2	12077222
Pubmed	Ureaplasma parvum lipoproteins, including MB antigen, activate NF-{kappa}B through TLR1, TLR2 and TLR6.	TLR6 TLR1	2.95e-06	3	35	2	18451040
Pubmed	TLR1- and TLR6-independent recognition of bacterial lipopeptides.	TLR6 TLR1	2.95e-06	3	35	2	16455646
Pubmed	Toll-like receptor polymorphisms are associated with increased neurosyphilis risk.	TLR6 TLR1	2.95e-06	3	35	2	24922103
Pubmed	Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells.	TLR6 TLR1	2.95e-06	3	35	2	24683188
Pubmed	A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6.	TLR6 TLR1	2.95e-06	3	35	2	16177110
Pubmed	Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins.	TLR6 TLR1	2.95e-06	3	35	2	17595379
Pubmed	Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.	TLR6 TLR1	2.95e-06	3	35	2	22150367
Pubmed	Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.	TLR6 TLR1	2.95e-06	3	35	2	18056480
Pubmed	Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.	TLR6 TLR1	2.95e-06	3	35	2	16374251
Pubmed	TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.	TLR6 TLR1	2.95e-06	3	35	2	21998742
Pubmed	Soluble Toll-like receptor 1 family members in the amniotic fluid of women with preterm prelabor rupture of the membranes.	TLR6 TLR1	2.95e-06	3	35	2	22280448
Pubmed	Toll-like receptor 1, 2 and 6 polymorphisms: no association with 11 serum cytokine concentrations.	TLR6 TLR1	2.95e-06	3	35	2	30028533
Pubmed	Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence.	KCNK3 KCNK15	2.95e-06	3	35	2	39215006
Pubmed	Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.	TLR6 TLR1	5.90e-06	4	35	2	23255565
Pubmed	Toll-like receptor heterodimer variants protect from childhood asthma.	TLR6 TLR1	5.90e-06	4	35	2	18547625
Pubmed	TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation.	TLR6 TLR1	5.90e-06	4	35	2	22198949
Pubmed	Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population.	TLR6 TLR1	5.90e-06	4	35	2	20815312
Pubmed	Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.	TLR6 TLR1	5.90e-06	4	35	2	20348427
Pubmed	Characterization of non-canonical Polycomb Repressive Complex 1 subunits during early mouse embryogenesis.	L3MBTL1 L3MBTL2	5.90e-06	4	35	2	27081692
Pubmed	A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide.	TLR6 TLR1	5.90e-06	4	35	2	20478617
Pubmed	Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes.	TLR6 TLR1	5.90e-06	4	35	2	24860120
Pubmed	Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.	TLR6 TLR1	5.90e-06	4	35	2	11739528
Pubmed	Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.	TLR6 TLR1	5.90e-06	4	35	2	11081518
Pubmed	Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS.	TLR6 TLR1	5.90e-06	4	35	2	16622218
Pubmed	Association of Toll-like receptor polymorphisms with HIV status in North Americans.	TLR6 TLR1	5.90e-06	4	35	2	25253287
Pubmed	The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.	TLR6 KDM6B TIPARP TLR1	6.28e-06	119	35	4	24162774
Pubmed	Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.	TLR6 TLR1	9.82e-06	5	35	2	24014382
Pubmed	Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.	TLR6 TLR1	9.82e-06	5	35	2	22703024
Pubmed	Association of MBL2, TLR1, TLR2 and TLR6 Polymorphisms With Production of IFN-γ and IL-12 in BCG Osteitis Survivors R1.	TLR6 TLR1	9.82e-06	5	35	2	27755461
Pubmed	TLR-dependent control of Francisella tularensis infection and host inflammatory responses.	TLR6 TLR1	9.82e-06	5	35	2	19936231
Pubmed	Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses.	TLR6 TLR1	9.82e-06	5	35	2	15294986
Pubmed	Association between toll-like receptors/CD14 gene polymorphisms and inflammatory bowel disease in Korean population.	TLR6 TLR1	9.82e-06	5	35	2	22219617
Pubmed	Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans.	TLR6 TLR1	9.82e-06	5	35	2	19771452
Pubmed	TLR6: A novel member of an expanding toll-like receptor family.	TLR6 TLR1	9.82e-06	5	35	2	10231569
Pubmed	Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.	TLR6 TLR1	9.82e-06	5	35	2	16880211
Pubmed	Abnormal high-density lipoprotein induces endothelial dysfunction via activation of Toll-like receptor-2.	TLR6 TLR1	9.82e-06	5	35	2	23477738
Pubmed	Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk.	TLR6 TLR1	9.82e-06	5	35	2	16537705
Pubmed	A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma.	TLR6 TLR1	9.82e-06	5	35	2	19029192
Pubmed	NF-κB is activated from endosomal compartments in antiphospholipid antibodies-treated human monocytes.	TLR6 TLR1	9.82e-06	5	35	2	24612386
Pubmed	Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis.	TLR6 TLR1	9.82e-06	5	35	2	23077245
Pubmed	TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.	TLR6 TLR1	9.82e-06	5	35	2	19362712
Pubmed	Respiratory syncytial virus activates innate immunity through Toll-like receptor 2.	TLR6 TLR1	9.82e-06	5	35	2	19019963
Pubmed	TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.	TLR6 TLR1	1.47e-05	6	35	2	32652111
Pubmed	Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.	TLR6 TLR1	1.47e-05	6	35	2	17004992
Pubmed	Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in experimental autoimmune encephalomyelitis.	TLR6 TLR1	1.47e-05	6	35	2	21685327
Pubmed	Structural and functional understanding of the toll-like receptors.	TLR6 TLR1	1.47e-05	6	35	2	33576548
Pubmed	Genetic differences between five European populations.	TLR6 TLR1	1.47e-05	6	35	2	20616560
Pubmed	Symbionts exploit complex signaling to educate the immune system.	TLR6 TLR1	1.47e-05	6	35	2	31811024
Pubmed	Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses.	TLR6 TLR1	1.47e-05	6	35	2	18195069
Pubmed	Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors.	TLR6 TLR1	1.47e-05	6	35	2	10426995
Pubmed	Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India.	TLR6 TLR1	1.47e-05	6	35	2	20797905
Pubmed	Isolated Toll-like receptor transmembrane domains are capable of oligomerization.	TLR6 TLR1	2.06e-05	7	35	2	23155421
Pubmed	Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases.	TLR6 TLR1	2.06e-05	7	35	2	18776592
Pubmed	Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease.	TLR6 TLR1	2.06e-05	7	35	2	17595233
Pubmed	Identification of genetic loci associated with Helicobacter pylori serologic status.	TLR6 TLR1	2.06e-05	7	35	2	23652523
Pubmed	Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.	TLR6 TLR1	2.74e-05	8	35	2	20100933
Pubmed	Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.	TLR6 TLR1	2.74e-05	8	35	2	11561001
Pubmed	TLR2 activation inhibits embryonic neural progenitor cell proliferation.	TLR6 TLR1	2.74e-05	8	35	2	20456021
Pubmed	HIV-1 Structural Proteins Serve as PAMPs for TLR2 Heterodimers Significantly Increasing Infection and Innate Immune Activation.	TLR6 TLR1	3.53e-05	9	35	2	26347747
Pubmed	Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.	TLR6 TLR1	3.53e-05	9	35	2	24091496
Pubmed	Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae.	TLR6 TLR1	3.53e-05	9	35	2	19200604
Pubmed	FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.	TLR6 TLR1	3.53e-05	9	35	2	20554749
Pubmed	Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.	TLR6 TLR1	3.53e-05	9	35	2	19543401
Pubmed	[Expression of toll-like receptors in human epidermal keratinocytes].	TLR6 TLR1	4.40e-05	10	35	2	18686608
Pubmed	Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.	TLR6 TLR1	4.40e-05	10	35	2	20227302
Cytoband	20q13.12	SYS1 L3MBTL1 KCNK15	1.35e-05	60	35	3	20q13.12
Cytoband	4p14	TLR6 TLR1	4.77e-04	42	35	2	4p14
Cytoband	Ensembl 112 genes in cytogenetic band chr4p14	TLR6 TLR1	1.21e-03	67	35	2	chr4p14
Cytoband	12q24.31	KDM2B TMEM120B	1.72e-03	80	35	2	12q24.31
Cytoband	Ensembl 112 genes in cytogenetic band chr20q13	SYS1 L3MBTL1 KCNK15	4.06e-03	422	35	3	chr20q13
GeneFamily	Sterile alpha motif domain containing\|MBT domain containing	L3MBTL1 L3MBTL2	5.54e-05	9	23	2	1263
GeneFamily	CD molecules\|Toll like receptors	TLR6 TLR1	6.92e-05	10	23	2	948
GeneFamily	Potassium two pore domain channel subfamily K	KCNK3 KCNK15	1.61e-04	15	23	2	277
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM2B KDM6B	4.20e-04	24	23	2	485
Coexpression	QI_PBMC_ZOSTAVAX_AGE_50_75YO_CORRELATED_WITH_CONTRACTION_OF_VZV_SPECIFIC_T_CELLS_PEAK_TO_28DY_AT_1DYPOSITIVE	CYBB KDM2B L3MBTL2 RBL2 TIPARP TLR1	2.34e-06	294	35	6	M40873
Coexpression	BHAT_ESR1_TARGETS_VIA_AKT1_UP	TBC1D16 TMEM120B GSG1L KCNK15 TIPARP	3.41e-05	281	35	5	M2234
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADGRG3 TLR6 MBOAT1 DGAT1	9.84e-06	172	35	4	c05af6e559f6af0fb15cefa03ffa1413e98a1a4a
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Basophil\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADGRG3 TLR6 MBOAT1 DGAT1	9.84e-06	172	35	4	953b05f776348cff784e79c93df65841939d880f
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA6B KIF13B KIAA1755 SV2B	1.52e-05	192	35	4	3fc7a661ef39286abfd82ed8ab580011f01cb8fd
ToppCell	control-Lymphoid-B_cell\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CYBB TLR6 KDM6B TLR1	1.58e-05	194	35	4	a5284adca931a78b1c4592925c4860853ebd24f1
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D16 KDM2B ADGRL1 GPR45	1.61e-05	195	35	4	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	368C-Myeloid-Monocyte-CD14+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	CYBB SEMA6B KDM6B TIPARP	1.65e-05	196	35	4	8095b3c1a87ce5c1c7dcbd951806fa564c795068
ToppCell	moderate-Myeloid\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CYBB ADGRG3 KDM6B TLR1	1.65e-05	196	35	4	76a4c615ea7594e99c1a938d6900a1b262cc09f5
ToppCell	368C-Myeloid-Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	CYBB SEMA6B KDM6B TIPARP	1.65e-05	196	35	4	3b46a501590aa03e3b7e25943dd43b72ecaf8182
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYBB SEMA6B TLR6 TLR1	1.68e-05	197	35	4	10190b877bf46ba2163d203df9dd3b498c66e52f
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYBB SEMA6B TLR6 TLR1	1.71e-05	198	35	4	88635244a0b306d2cc50b8412fe47bb359c9cf00
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYBB SEMA6B TLR6 TLR1	1.75e-05	199	35	4	f34c15df58fbdc6c90e30800e26fabbf828ad10b
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYBB SEMA6B TLR6 TLR1	1.75e-05	199	35	4	5ceeed92f831d068ff4bb3994f420002338330e7
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	KCNK3 GRIN2B GPR45	1.72e-04	138	35	3	8d70e64843f7c3be8ee4203cc126fdf1001f0df5
ToppCell	E18.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYBB ADGRG3 DGAT1	1.99e-04	145	35	3	88e463d5396a8fea2b7b1ecf3c9b144e16b35234
ToppCell	E18.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYBB ADGRG3 DGAT1	1.99e-04	145	35	3	911fee7f27694393e348d94470a1a4e890038902
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KIF13B ADGRG3 DGAT1	2.24e-04	151	35	3	c1461d0dd622a081187eba77f454d2663df2732e
ToppCell	Hippocampus-Hematopoietic\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CYBB TLR6 TLR1	2.24e-04	151	35	3	81b2189afd72658f7e2539b856ba79cd49340215
ToppCell	facs-Lung-18m-Hematologic-myeloid-leukocyte-proliferating_myeloid_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYBB GSG1L TLR1	2.33e-04	153	35	3	596bb7cfd1c713708ce73df30d890a0233eae7f7
ToppCell	facs-Lung-18m-Hematologic-myeloid-leukocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYBB GSG1L TLR1	2.33e-04	153	35	3	8cc2667213bfac37545bb63181e88ef1f1834413
ToppCell	Globus_pallidus-Hematopoietic\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	CYBB TLR6 TLR1	2.47e-04	156	35	3	67cdaadc3b917f7072adce16c0391472c14a2563
ToppCell	356C-Fibroblasts-Fibroblast-D-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CYBB ADGRG3 GALR3	2.61e-04	159	35	3	299e2162a82e31196d7f3a110c2db622349edfff
ToppCell	356C-Fibroblasts-Fibroblast-D\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CYBB ADGRG3 GALR3	2.61e-04	159	35	3	0a3a363b30a8c741e1a3e2525725108d03c21776
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC17A2 ADGRG3 TLR6	2.66e-04	160	35	3	5d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCell	Endothelial-B-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	GRIN2B L3MBTL1 MBOAT1	2.91e-04	165	35	3	10087d8bd2985906ef19547fe77eb178ae5e1638
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibrocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYBB GALR3 TLR1	2.91e-04	165	35	3	8a52f2dbcbd2bc1662b5e3fac381463fdcc3bf14
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KDM6B DGAT1 TLR1	3.07e-04	168	35	3	cc0dd43d5cda01e643d8e8d74ec7617d61890760
ToppCell	Endothelial-B-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	ADGRG3 GRIN2B SV2B	3.07e-04	168	35	3	4977c3837fbb1f36c89fddd5764e37290ac25ad8
ToppCell	droplet-Lung-nan-18m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 MBOAT1 DGAT1	3.12e-04	169	35	3	f2e20049a17eee533d49bd5f24a51962d123d132
ToppCell	droplet-Lung-nan-18m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 MBOAT1 DGAT1	3.12e-04	169	35	3	4c6892551e9dec94fc62b3beab1e6d424639a1e9
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYBB TLR6 TLR1	3.12e-04	169	35	3	15a9183c838cc6384d7f5dfeae3d30602964c9b3
ToppCell	droplet-Lung-nan-3m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 MBOAT1 DGAT1	3.12e-04	169	35	3	da607c1d068038d5a3d1117f6aa6e4c6f3552e97
ToppCell	390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|390C / Donor, Lineage, Cell class and subclass (all cells)	CYBB TLR6 TLR1	3.12e-04	169	35	3	2c851b2703c7b8b656026f996f5fc027e4a79b36
ToppCell	droplet-Lung-nan-3m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 MBOAT1 DGAT1	3.12e-04	169	35	3	a14b46231e079a0fd9f3ca13d5d48113be76fd0f
ToppCell	droplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYBB KDM2B SV2B	3.17e-04	170	35	3	138235227fc4c3d660c3a06e8e5167bf64f076b3
ToppCell	droplet-Kidney-KIDNEY-1m-Myeloid-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYBB MBOAT1 TLR1	3.23e-04	171	35	3	d9ad6a3bce3556abd24af1630bf4a99594437c3a
ToppCell	Myeloid-Myeloid-D_(Mast_cell)\|Myeloid / shred on cell class and cell subclass (v4)	ADGRG3 MBOAT1 RBL2	3.23e-04	171	35	3	5f1aafc4c55a9c6c3153430186a8a351425a3cb9
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYBB SEMA6B TLR6	3.23e-04	171	35	3	5e93c76ee60f9d0590ebb140812653a5e1369417
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYBB ADGRG3 TLR1	3.28e-04	172	35	3	2bbe3f601a56577d200aa7ba7031f7c19b988cc1
ToppCell	droplet-Lung-nan-21m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 MBOAT1 DGAT1	3.28e-04	172	35	3	b3c53fd7e50f36de6a8585ae21d04e17932f262c
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYBB ADGRG3 TLR1	3.28e-04	172	35	3	3ffe721f62c0d20c1d765ecb15ed4e1aa88099f7
ToppCell	droplet-Lung-nan-21m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG3 MBOAT1 DGAT1	3.28e-04	172	35	3	1b133be191252e7053faeacf9547730c3ae28d21
ToppCell	droplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG3 MBOAT1 DGAT1	3.34e-04	173	35	3	117163c5cd2b7aaa1c0682c8ac44b4249df4d2f8
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 TBC1D16 TRPC1	3.34e-04	173	35	3	3059325901b1e5e12a1a91183f14267288b2f600
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADGRG3 MBOAT1 DGAT1	3.34e-04	173	35	3	4282b47b33325472f52a4085986988911a372ed8
ToppCell	droplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG3 MBOAT1 DGAT1	3.34e-04	173	35	3	b2c55084ef6dac0e329c2e65c24cfe0045859c30
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Basophil\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADGRG3 MBOAT1 DGAT1	3.34e-04	173	35	3	8ca650542655c27516029e5bace97ff1b9dcc256
ToppCell	droplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG3 MBOAT1 DGAT1	3.34e-04	173	35	3	120dd20e8a71f9169a1596b6171df7aa0b96dd15
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Lymphocytic-T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYBB ADGRG3 TLR1	3.34e-04	173	35	3	7c5e4809205ce1a0a301c15442af00a2e2b9b301
ToppCell	facs-Lung-EPCAM-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 TBC1D16 TRPC1	3.34e-04	173	35	3	36c8338463ee4cc432f568728d55989360f9a68d
ToppCell	droplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG3 MBOAT1 DGAT1	3.34e-04	173	35	3	01df9baeedf30e3a4891738554cdd300394dbb96
ToppCell	droplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG3 MBOAT1 DGAT1	3.40e-04	174	35	3	009e88a6c79689a5d88b0af50aa89aa03b33f800
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Lymphatic_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ADGRG3 GSG1L SV2B	3.40e-04	174	35	3	d551bc29afef071adf4c9bb80345352ec33441d8
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TBC1D16 KIAA1755 TRPC1	3.40e-04	174	35	3	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	droplet-Lung-21m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG3 MBOAT1 DGAT1	3.40e-04	174	35	3	8a8e98e62c2859c004b44dbce6974c9639ebeac6
ToppCell	droplet-Lung-21m-Hematologic-myeloid-Basophil/Mast_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG3 MBOAT1 DGAT1	3.40e-04	174	35	3	31f7127faabcb1092bb9827db625f57cf7d8240e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRG3 GRIN2B SV2B	3.45e-04	175	35	3	9a96a946db731ba24c9be34bedebf1f4a1372b9e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRG3 GRIN2B SV2B	3.45e-04	175	35	3	54c1f080195ad8392a095e83b56a4b54073d4c0d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRG3 GRIN2B SV2B	3.45e-04	175	35	3	2b51406a2c2daa13ab4ed283ede038cd11d9e641
ToppCell	Control-Neuronal_cells\|Control / group, cell type (main and fine annotations)	ADGRG3 GRIN2B SV2B	3.51e-04	176	35	3	c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG3 GRIN2B SV2B	3.51e-04	176	35	3	5d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EML1 GSG1L SV2B	3.51e-04	176	35	3	07abf29d681abdd6c7cc87f9eaf9377e92ce212c
ToppCell	Control-Neuronal_cells-Neuronal_cells\|Control / group, cell type (main and fine annotations)	ADGRG3 GRIN2B SV2B	3.51e-04	176	35	3	98c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KCNK3 TBC1D16 MBOAT1	3.51e-04	176	35	3	e2b59a904c5c8f9c88e1e63788e9b6485f22edd0
ToppCell	droplet-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KCNK3 TBC1D16 MBOAT1	3.51e-04	176	35	3	f931192e3cc65414e2245354f443473696cc7ce8
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 SV2B TIPARP	3.57e-04	177	35	3	1dc69c661e70e7e22bd9d7cf953eb638da9fd43c
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 TBC1D16 MBOAT1	3.57e-04	177	35	3	65709bd546cb1ec6aa2ddd8b2adb46e174eb9a9a
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADGRG3 GRIN2B SV2B	3.57e-04	177	35	3	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	metastatic_Lymph_Node-Endothelial_cells\|metastatic_Lymph_Node / Location, Cell class and cell subclass	ADGRG3 GSG1L SV2B	3.57e-04	177	35	3	71bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 SV2B TIPARP	3.57e-04	177	35	3	426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 TBC1D16 MBOAT1	3.57e-04	177	35	3	8684d47a547e2a06496f15e8da0200ecddc431e0
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D16 TLR6 TLR1	3.69e-04	179	35	3	6eb84fe9691ad40127b2d1f1c672428333c8fab4
ToppCell	COVID-19-Heart-Lymph_EC\|Heart / Disease (COVID-19 only), tissue and cell type	ADGRG3 GRIN2B SV2B	3.69e-04	179	35	3	411620201a860716a8773b92f50f7b94ef34a586
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D16 TLR6 TLR1	3.69e-04	179	35	3	2c3abd646d2c8992e8ff76a824eab5beba8ba4c6
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid-cDC2\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CYBB TLR6 TLR1	3.69e-04	179	35	3	1016af3d61a9276a792629f8b1a28a93038e29c1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF13B MBOAT1 TRPC1	3.75e-04	180	35	3	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	ADGRG3 GRIN2B SV2B	3.81e-04	181	35	3	b244ecaa442bbef51289d8ec574ef08fa9e96318
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA1755 CAPN5 GRIN2B	3.81e-04	181	35	3	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_monocyte_(14)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CYBB ADGRG3 TLR1	3.81e-04	181	35	3	3457c1d431db4282be5a6243119e48960748ede7
ToppCell	367C-Endothelial_cells-Endothelial-F_(Lymphatics)\|367C / Donor, Lineage, Cell class and subclass (all cells)	ADGRG3 GRIN2B SV2B	3.81e-04	181	35	3	dd79de8098edb385a0f85d0e9621503cdf76ec43
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 KDM6B SV2B	3.87e-04	182	35	3	f5f42e23832d0210560009ce6fd8eee89751e252
ToppCell	droplet-Thymus-nan-18m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 EML1 MEGF8	3.87e-04	182	35	3	f6717e97e87513384149800c9fd8dea821ab9393
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYBB SEMA6B KDM6B	3.87e-04	182	35	3	c3eafdc11858566aa7692b2f5dbe72ac01fb769a
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG3 KDM6B SV2B	3.87e-04	182	35	3	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial-I_cells_(CCK+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNK3 TAAR1 GSG1L	3.87e-04	182	35	3	27a27a3eaeacb087c9601d5bb1c9e57cdfcd9d77
ToppCell	cellseq2-Immune-Hematopoietic-Granulocytic-Neutrophil\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADGRG3 KDM6B TLR1	3.87e-04	182	35	3	1932d77491d6d46278f01fd70eb469ef1b356619
ToppCell	droplet-Thymus-nan-18m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNK3 EML1 MEGF8	3.87e-04	182	35	3	c33b0d532822186a1e8e645500347972468718c0
ToppCell	cellseq2-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYBB TLR6 TLR1	3.94e-04	183	35	3	9840706f972387241bf1d4ba8af25efc3214a91b
ToppCell	cellseq2-Immune-Hematopoietic-Granulocytic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADGRG3 KDM6B TLR1	3.94e-04	183	35	3	cfbf8539104cef9ca830ad4f6bb278746f7078f7
ToppCell	cellseq2-Immune-Immune_Myeloid-Myeloid_Dendritic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYBB TLR6 TLR1	3.94e-04	183	35	3	409cb52cf4c967e52bf75a6680bcbe87f638c75d
ToppCell	cellseq2-Immune-Hematopoietic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ADGRG3 KDM6B TLR1	3.94e-04	183	35	3	324ec4374b552da7ce03809945b3a0798342d4ba
ToppCell	3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADGRG3 GRIN2B SV2B	4.00e-04	184	35	3	968afa6b5ba84169377a24c150bb68749fa674d9
ToppCell	P28-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCNK3 MBOAT1 TRPC1	4.00e-04	184	35	3	23c24ab5786af33d605bc445d06117b9da6c6331
ToppCell	3'-Broncho-tracheal-Endothelial-Lymphatic_EC\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADGRG3 GRIN2B SV2B	4.00e-04	184	35	3	15cbddea9efb2346a2028d77edfe9ba32923568f
ToppCell	5'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA6B KIF13B KIAA1755	4.00e-04	184	35	3	7aa245b73e10fd73d292e822de6b72920aa12355
ToppCell	3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADGRG3 GRIN2B SV2B	4.00e-04	184	35	3	0087c605c161fd8a39aa394f51994a04e8353bf1
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADGRG3 KDM6B SV2B	4.00e-04	184	35	3	453295362888c9a59d0e73c7a5b15914c50ff591
ToppCell	3'-Broncho-tracheal-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADGRG3 GRIN2B SV2B	4.00e-04	184	35	3	920f95625978132c2b6c76654ef6298244103e2d
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADGRG3 GRIN2B SV2B	4.00e-04	184	35	3	1a4297b9d3cc4744bea0408fd5ee7b33ba2a1d78
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYBB SEMA6B KDM6B	4.00e-04	184	35	3	b45b1fdba13c8ed2a04a4fb3b62d8ad92785c768
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYBB SEMA6B KDM6B	4.00e-04	184	35	3	d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
Drug	MK-886; Up 200; 1uM; MCF7; HG-U133A	TRMO CAPN5 L3MBTL1 TLR6 KDM6B	1.24e-05	198	35	5	601_UP
Drug	Hexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; MCF7; HT_HG-U133A	ADGRL1 TRMO CAPN5 KDM6B TRPC1	1.27e-05	199	35	5	6244_DN
Drug	Naringin hydrate [11032-30-7]; Up 200; 6.6uM; PC3; HT_HG-U133A	SLC17A2 GRIN2B KDM6B GPR45 TRPC1	1.30e-05	200	35	5	4605_UP
Drug	glycerylcysteine	TLR6 TLR1	1.37e-05	4	35	2	CID000152469
Disease	aspergillosis (is_implicated_in)	TLR6 TLR1	3.38e-05	8	33	2	DOID:13564 (is_implicated_in)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR6 TLR1	1.63e-04	17	33	2	DOID:8677 (biomarker_via_orthology)
Disease	tuberculosis (is_implicated_in)	TLR6 TLR1	4.50e-04	28	33	2	DOID:399 (is_implicated_in)
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	ADGRL1 GRIN2B	4.50e-04	28	33	2	DOID:1094 (implicated_via_orthology)
Disease	right ventricular diastolic volume measurement	KCNK3 RBL2	4.50e-04	28	33	2	EFO_0021814
Disease	right ventricular systolic volume measurement	KCNK3 RBL2	7.05e-04	35	33	2	EFO_0021815
Disease	wheezing	SPG11 GSG1L	2.41e-03	65	33	2	EFO_0009715
Disease	Alcoholic Intoxication, Chronic	GRIN2B GALR3 TIPARP	3.30e-03	268	33	3	C0001973
Disease	response to angiotensin-converting enzyme inhibitor	KCNK3 MBOAT1	3.45e-03	78	33	2	EFO_0005325
Disease	age of onset of asthma	TLR6 TLR1	3.54e-03	79	33	2	OBA_2001001
Disease	asthma, allergic disease	TLR6 TLR1	3.54e-03	79	33	2	MONDO_0004979, MONDO_0005271
Disease	Kidney Diseases	CYBB SV2B	4.37e-03	88	33	2	C0022658

Protein segments in the cluster

Peptide	Gene	Start	Entry
HYFFLAAFSWLCLEG	ADGRL1	931	O94910
FLFRNFHTGIWYSCE	GSG1L	96	Q6UXU4
RGAVFHYFLLCAFTW	ADGRG3	341	Q86Y34
AYAGIFHFHFWRFGE	CAPN5	116	O15484
HLIWLIFFYWLFHSC	DGAT1	331	O75907
IFFYWLFHSCLNAVA	DGAT1	336	O75907
SIYHTVWKFFCRDHF	TIPARP	341	Q7Z3E1
TVSEIFHFCWVLFIY	RBL2	196	Q08999
FHFCWVLFIYAKGNF	RBL2	201	Q08999
GLDWFCYHASSHAIF	L3MBTL2	471	Q969R5
VAFSHFEGWTFFHAY	KCNK15	176	Q9H427
FPYCHTEWVHFFQKL	KIAA1755	711	Q5JYT7
LCIGAAAFSHYEHWT	KCNK3	171	O14649
FAVHEHYWETISAFC	KDM6B	1411	O15054
LRLHFDGYSECHDFW	L3MBTL1	336	Q9Y468
AHHWISIPFFAVYVC	OR51B2	21	Q9Y5P1
IFFYHLGCHQWVSGA	MEGF8	481	Q7Z7M0
HFGDHFCRLSATLYW	GPR45	101	Q9Y5Y3
HHALILCFWYGRFAF	GALR3	251	O60755
FHIDFGGTSVWYHVF	KDM2B	241	Q8NHM5
VIFCFGWYSVHLFVL	MBOAT1	76	Q6ZNC8
WYTHHLFVIFFIGLA	CYBB	206	P04839
IEWATYTCTLGFHVF	EML1	716	O00423
PQHLSHFVFCKYSFW	KIF13B	881	Q9NQT8
VTVHFFHLLGCWFYS	SYS1	96	Q8N2H4
YHFHSWRVFVIVCAL	SV2B	271	Q7L1I2
FCGHFWQLYNAVTLF	TMEM120B	276	A0PK00
FVQSEWCHYELYFAH	TLR1	701	Q15399
WDFHSQFILYCLEHS	SPG11	986	Q96JI7
CFALFWYIFSLAHVA	TRPC1	591	P48995
FVHAVEWGSHVYFFF	SEMA6B	231	Q9H3T3
LFYFTVDIAHVTCWF	TRMO	396	Q9BU70
CWAHYQTDYFHLFIC	TBC1D16	631	Q8TBP0
GFFSHFWLCTIILTY	SLC17A2	281	O00624
EHCWYFGEVFCKIHT	TAAR1	86	Q96RJ0
FVQSEWCHYELYFAH	TLR6	706	Q9Y2C9
FICEHLFYWQFRHCF	GRIN2B	836	Q13224