Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R8 TAS2R43 TAS2R33

3.44e-0527473GO:0033038
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R8 TAS2R43 TAS2R33

6.35e-0533473GO:0008527
GeneOntologyMolecularFunctionATP-dependent activity

ERCC6L2 KIF28P TMEM30A MYH8 ATP1B1 RECQL4 DNAH11

5.42e-04614477GO:0140657
MousePhenopersistence of hyaloid vascular system

AGAP5 TADA1 ZSWIM6 AGAP9 ATP1B1 FAM162A

2.01e-05223366MP:0001289
DomainPH

AGAP5 CNKSR2 AGAP9 FGD6 IPCEF1 PHLDB2

5.15e-05278456SM00233
DomainPH_DOMAIN

AGAP5 CNKSR2 AGAP9 FGD6 IPCEF1 PHLDB2

5.26e-05279456PS50003
DomainPH_domain

AGAP5 CNKSR2 AGAP9 FGD6 IPCEF1 PHLDB2

5.36e-05280456IPR001849
DomainFAD_binding_3

MICAL3 MICAL2

8.46e-056452PF01494
DomainSynaptobrevin/VAMP

VAMP8 VAMP3

8.46e-056452IPR016444
DomainFAD-bd

MICAL3 MICAL2

8.46e-056452IPR002938
DomainSYNAPTOBREVIN

VAMP8 VAMP3

1.57e-048452PS00417
Domain-

VAMP8 VAMP3

1.57e-0484521.10.3840.10
DomainSynaptobrevin

VAMP8 VAMP3

3.08e-0411452PF00957
Domain-

AGAP5 CNKSR2 AGAP9 FGD6 IPCEF1 PHLDB2

3.31e-043914562.30.29.30
DomainV_SNARE

VAMP8 VAMP3

3.69e-0412452PS50892
DomainSynaptobrevin

VAMP8 VAMP3

4.35e-0413452IPR001388
DomainPH_dom-like

AGAP5 CNKSR2 AGAP9 FGD6 IPCEF1 PHLDB2

5.21e-04426456IPR011993
DomainTAS2R

TAS2R8 TAS2R43

1.78e-0326452PF05296
DomainT2R

TAS2R8 TAS2R43

1.78e-0326452IPR007960
DomainArfGap

AGAP5 AGAP9

2.21e-0329452SM00105
DomainARFGAP

AGAP5 AGAP9

2.21e-0329452PS50115
DomainArfGAP

AGAP5 AGAP9

2.21e-0329452IPR001164
DomainArfGap

AGAP5 AGAP9

2.21e-0329452PF01412
DomainPH

CNKSR2 FGD6 IPCEF1 PHLDB2

2.21e-03229454PF00169
DomainDNA/RNA_helicase_DEAH_CS

ERCC6L2 RECQL4

3.21e-0335452IPR002464
DomainDEAH_ATP_HELICASE

ERCC6L2 RECQL4

3.78e-0338452PS00690
Domain-

MICAL3 MICAL2

8.05e-03564523.50.50.60
DomainFAD/NAD-binding_dom

MICAL3 MICAL2

8.33e-0357452IPR023753
DomainCH

MICAL3 MICAL2

1.07e-0265452SM00033
DomainLIM

MICAL3 MICAL2

1.20e-0269452PF00412
Domain-

MICAL3 MICAL2

1.24e-02704522.10.110.10
DomainCH

MICAL3 MICAL2

1.24e-0270452PF00307
DomainLIM_DOMAIN_2

MICAL3 MICAL2

1.27e-0271452PS50023
DomainZnf_LIM

MICAL3 MICAL2

1.27e-0271452IPR001781
DomainLIM_DOMAIN_1

MICAL3 MICAL2

1.27e-0271452PS00478
Domain-

MICAL3 MICAL2

1.27e-02714521.10.418.10
DomainLIM

MICAL3 MICAL2

1.27e-0271452SM00132
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

TAS2R8 TAS2R43 GABBR1

9.19e-0539323M793
Pubmed

Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling.

EPHX1 VAMP8 ATP1B1 VAMP3

3.42e-067448417255364
Pubmed

Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms.

VAMP8 VAMP3

5.59e-06348218250339
Pubmed

Endobrevin/VAMP-8 is the primary v-SNARE for the platelet release reaction.

VAMP8 VAMP3

5.59e-06348217065550
Pubmed

Finding underlying genetic mechanisms of two patients with autism spectrum disorder carrying familial apparently balanced chromosomal translocations.

CNKSR2 JMJD1C

5.59e-06348233591602
Pubmed

VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells.

VAMP8 VAMP3

5.59e-06348222144578
Pubmed

Increased formation of VAMP-3-containing SNARE complexes in mast cells from VAMP-8 deficient cells. appetite.

VAMP8 VAMP3

5.59e-06348219274433
Pubmed

Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.

MICAL3 MICAL2

1.12e-05448224440334
Pubmed

The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM.

VAMP8 VAMP3

1.12e-05448222118466
Pubmed

Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7.

VAMP8 VAMP3

1.12e-05448222589474
Pubmed

The MICAL proteins and rab1: a possible link to the cytoskeleton?

MICAL3 MICAL2

1.12e-05448215694364
Pubmed

Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes.

VAMP8 VAMP3

1.12e-05448219759285
Pubmed

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

MICAL3 CNKSR2 MLXIP UBR5

1.14e-0510048410048485
Pubmed

Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis.

VAMP8 VAMP3

1.86e-05548226209658
Pubmed

MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.

MICAL3 MICAL2

1.86e-05548212110185
Pubmed

Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs.

VAMP8 VAMP3

2.79e-05648211786915
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

TOPBP1 SHLD2 TADA1 UBR5 JMJD1C RECQL4

3.65e-0545348629656893
Pubmed

Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment.

VAMP8 VAMP3

3.90e-05748210820264
Pubmed

Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.

TOPBP1 UBR5

3.90e-05748211714696
Pubmed

Coiled-coil interactions are required for post-Golgi R-SNARE trafficking.

VAMP8 VAMP3

3.90e-05748219557002
Pubmed

Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform.

VAMP8 VAMP3

3.90e-05748211839770
Pubmed

Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells.

VAMP8 VAMP3

3.90e-05748218253931
Pubmed

Fusogenic pairings of vesicle-associated membrane proteins (VAMPs) and plasma membrane t-SNAREs--VAMP5 as the exception.

VAMP8 VAMP3

3.90e-05748221151919
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

AGAP5 CNKSR2 AGAP9 ATP1B1 UBR5

4.28e-0528148528706196
Pubmed

CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.

TOPBP1 UBR5

5.19e-05848234145035
Pubmed

Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane.

VAMP8 VAMP3

5.19e-05848212828989
Pubmed

Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy.

TOPBP1 UBR5

5.19e-05848235768646
Pubmed

Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.

VAMP8 VAMP3

5.19e-05848212130530
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

MICAL3 FGD6 CCDC191 JMJD1C

6.03e-0515348410718198
Pubmed

Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration.

TMEM30A VAMP3

6.67e-05948223269685
Pubmed

A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function.

VAMP8 VAMP3

6.67e-05948211101518
Pubmed

Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells.

VAMP8 VAMP3

6.67e-05948211278762
Pubmed

GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.

AGAP5 AGAP9

6.67e-05948212640130
Pubmed

AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.

AGAP5 AGAP9

8.33e-051048220664521
Pubmed

SNAREs and SNARE regulators in membrane fusion and exocytosis.

VAMP8 VAMP3

8.33e-051048210379359
Pubmed

AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.

AGAP5 AGAP9

1.02e-041148215381706
Pubmed

MRE11 complex links RECQ5 helicase to sites of DNA damage.

UBR5 RECQL4

1.02e-041148219270065
Pubmed

High-resolution linkage map in the vicinity of the Lp locus.

EPHX1 ATP1B1

1.22e-04124827607671
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

MICAL3 VAMP8 FGD6 MICAL2 PHLDB2 VAMP3

1.28e-0456948630639242
Pubmed

Sdmg1 is a conserved transmembrane protein associated with germ cell sex determination and germline-soma interactions in mice.

VAMP8 VAMP3

1.44e-041348218321981
Pubmed

The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.

AGAP5 AGAP9

1.44e-041348227713690
Pubmed

Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.

VAMP8 VAMP3

1.68e-041448226553929
Pubmed

GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.

AGAP5 AGAP9

1.68e-041448222453919
Pubmed

The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes.

VAMP8 VAMP3

2.21e-041648227791468
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MICAL3 CNKSR2 ZSWIM6 MLXIP UBR5

2.42e-0440748512693553
Pubmed

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.

DNAJC28 JMJD1C RECQL4

3.03e-049448325201988
Pubmed

A novel family of mammalian taste receptors.

TAS2R8 TAS2R43

3.85e-042148210761934
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

MICAL3 UBR5 PHLDB2

4.07e-0410448331240132
Pubmed

The molecular receptive ranges of human TAS2R bitter taste receptors.

TAS2R8 TAS2R43

4.63e-042348220022913
Pubmed

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.

SHLD2 TMEM30A ST3GAL3 ZSWIM6 ATP1B1 GABBR1 AHSA2P

4.74e-04102148726760575
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

FUNDC2 TMEM30A VAMP8 TASOR JMJD1C YTHDF3

4.96e-0473348634672954
Pubmed

Receptors for bitter and sweet taste.

TAS2R8 TAS2R43

5.48e-042548212139982
Pubmed

Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.

AGAP5 AGAP9 UBR5

5.60e-0411648330652415
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

FUNDC2 VAMP8 ATP1B1 UBR5 FAM162A PHLDB2

5.75e-0475448633060197
Pubmed

Molecular mechanisms of bitter and sweet taste transduction.

TAS2R8 TAS2R43

5.93e-042648211696554
Pubmed

Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

TAS2R8 TAS2R43

6.40e-042748212581520
Pubmed

Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.

TAS2R8 TAS2R43

6.89e-042848215744053
Pubmed

Evolution of bitter taste receptors in humans and apes.

TAS2R8 TAS2R43

1.02e-033448215496549
Pubmed

Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.

CMKLR2 ZSWIM6

1.08e-033548222688191
Pubmed

Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.

TADA1 ATP1B1

1.34e-033948219064610
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

AGAP5 CNKSR2 AGAP9 FGD6 IPCEF1 PHLDB2

2.10e-06206346682
GeneFamilyTaste 2 receptors

TAS2R8 TAS2R43 TAS2R33

5.30e-05393431162
GeneFamilyVesicle associated membrane proteins

VAMP8 VAMP3

7.17e-05734212
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

AGAP5 AGAP9

4.59e-04173421291
GeneFamilyArfGAPs

AGAP5 AGAP9

1.75e-0333342395
GeneFamilyLIM domain containing

MICAL3 MICAL2

5.49e-03593421218
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT1_Precursor|E16.5-samps / Age Group, Lineage, Cell class and subclass

CAPN9 CNKSR2 ATP1B1 MICAL2

2.10e-051544748a643d91896af9b630a715fb284c1523d01ad1a3
ToppCellPND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP1B1 MICAL2 SERPINA7 DNAH11

2.44e-05160474028b5261a1da832d52f66fb620db83e5fbbd874a
ToppCellPND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP1B1 MICAL2 SERPINA7 DNAH11

2.44e-051604741f4ee446436726c3d373f56d87dd80b6a12e8b9e
ToppCellFrontal_cortex|World / BrainAtlas - Mouse McCarroll V32

SEBOX CNKSR2 MICAL2 IPCEF1

2.69e-05164474e09291711abf8680e78170328313719092b0142f
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IL1RAPL2 FGD6 IPCEF1 PHLDB2

3.16e-051714749e00c8191ca9d52151a49baf39f8581cb176fb76
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

IL1RAPL2 MICAL2 IPCEF1 PHLDB2

3.78e-05179474d3d3a9afaac28fa4f2c448c73d79bcbbbea088d7
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FGD6 IPCEF1 YTHDF3 RECQL4

4.12e-0518347491079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TADA1 IL1RAPL2 FGD6 PHLDB2

4.30e-051854745a0340c25196453f19e424d346efbf66d2c53ac3
Diseasecerebral palsy (implicated_via_orthology)

AGAP5 AGAP9

9.27e-0510432DOID:1969 (implicated_via_orthology)
DiseaseC-C motif chemokine 28 measurement

CMKLR2 JMJD1C

1.36e-0412432EFO_0020199
Diseasemigraine disorder, glucose measurement

ST3GAL3 JMJD1C

9.39e-0431432EFO_0004468, MONDO_0005277
DiseaseFEV/FEC ratio

ERCC6L2 MICAL3 CNKSR2 TRMT61B FGD6 JMJD1C PHLDB2

1.84e-031228437EFO_0004713
Diseasecoronary artery disease, plasminogen activator inhibitor 1 measurement

VAMP8 ATP1B1

3.83e-0363432EFO_0001645, EFO_0004792
Diseasemetabolite measurement, diet measurement

JMJD1C GABBR1

4.84e-0371432EFO_0004725, EFO_0008111
Diseasetissue plasminogen activator measurement, coronary artery disease

VAMP8 ATP1B1

4.84e-0371432EFO_0001645, EFO_0004791
DiseaseAlzheimer disease, educational attainment

ST3GAL3 ZSWIM6 JMJD1C

5.59e-03247433EFO_0011015, MONDO_0004975
Diseasepeak expiratory flow

ERCC6L2 MICAL3 ZSWIM6 PHLDB2

5.88e-03498434EFO_0009718

Protein segments in the cluster

PeptideGeneStartEntry
ETSAAKLKRKYWWKN

VAMP3

61

Q15836
TSQKVARKFWWKNVK

VAMP8

61

Q9BV40
KLIFFYEWNIKLGWK

AHSA2P

76

Q719I0
SWKKFIWNSEKKEFL

ATP1B1

11

P05026
WLKTWKKKYVTLCSN

AGAP9

341

Q5VTM2
FKVSLLTIIKKWSWM

DNAH11

1116

Q96DT5
KLNYWKAKALWAKLD

MICAL3

56

Q7RTP6
TRVKLFEKWGWKKIA

GABBR1

296

Q9UBS5
KTALSWVKKDAKIAW

JMJD1C

1821

Q15652
NVKHWPWMKLFFKIK

MYH8

826

P13535
KGFLNWMNLWKFIKI

DNAJC28

371

Q9NX36
WQKLLWKFSGLTSKL

OR2F1

301

Q13607
WKNFKGLKLQWRDKI

MLXIP

146

Q9HAP2
LWTKALKFMLINFKW

BECN2

406

A8MW95
KKVISYWRNEFDWKK

EPHX1

91

P07099
SFLSNKWKKFWVILK

IPCEF1

56

Q8WWN9
KWKKFWVILKGSSLY

IPCEF1

61

Q8WWN9
ILWITLRTWKKFVKF

CCDC191

871

Q8NCU4
KAWWKSFLNHLTRKK

C20orf144

26

Q9BQM9
KKGIAWWTDKNVKFR

TMEM30A

201

Q9NV96
KAFKTSFKLSWSKWK

KRBOX4

151

Q5JUW0
SFKLSWSKWKLCKKE

KRBOX4

156

Q5JUW0
TSLWKSNEKFLWKKF

ERCC6L2

1531

Q5T890
FKVFWDKLKQWINLF

CAPN9

586

O14815
VWIWSKAKFINRKFL

KIF28P

591

B7ZC32
KVTTWKAKALWYKLD

MICAL2

56

O94851
LAEFAKKQPWWRKLF

FUNDC2

56

Q9BWH2
WGNKKLKQTFLSVFW

TAS2R33

281

P0DSN6
WGNKKLKQTFLSVFW

TAS2R43

281

P59537
YWANLKLWFKQKISK

TADA1

26

Q96BN2
KQAWKQKWRKKGECF

RECQL4

376

O94761
WKGSKSSKLNSKFWK

IL1RAPL2

536

Q9NP60
ETKKKVFLWRTAAFW

SHLD2

481

Q86V20
FVLAGFKWQDFKWLK

ST3GAL3

226

Q11203
WFQKRWAKIIKNRKS

SEBOX

66

Q9HB31
KIKTWKKRWFVFDRN

PHLDB2

1156

Q86SQ0
WQKKILIWSGRFKKE

FAM162A

66

Q96A26
GKWQWKVHCKFQKKL

TASOR

1361

Q9UK61
WLKTWKKKYVTLCSN

AGAP5

296

A6NIR3
NAIVIWFTGFKWKKT

CMKLR2

56

P46091
KWKKTVTTLWFLNLA

CMKLR2

66

P46091
KGSFLSNKWKKFWVI

CNK3/IPCEF1

516

G9CGD6
SNKWKKFWVILKGSS

CNK3/IPCEF1

521

G9CGD6
WLWKKKDAKSYFSQK

CNKSR2

576

Q8WXI2
KWKGKFEVKWIFVKD

YTHDF3

496

Q7Z739
LAKKNYKHWRDSWKL

TRMT61B

286

Q9BVS5
SKTLKKWNRLLQKGW

SERPINA7

286

P05543
NKKPWKHFWFVIKNK

FGD6

1346

Q6ZV73
QKASWLKQLKKWNSV

ZSWIM6

461

Q9HCJ5
VTKWKNWEKALLRKS

SNAPC4

181

Q5SXM2
YIALVNWIDWIKKKK

TAS2R8

26

Q9NYW2
NWIDWIKKKKISTVD

TAS2R8

31

Q9NYW2
WIKTLWEKSQEKKIT

TOPBP1

171

Q92547
KLLQFKRWFWSIVEK

UBR5

2706

O95071