Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	postsynaptic membrane	ADORA2A ERBB3 GPR158 PTPRS NTRK3 NBEA RPH3A GABBR1	1.89e-04	405	82	8	GO:0045211
Domain	-	CEACAM19 HSPG2 COL7A1 PTPRS VSTM2L NTRK3 PVR L1CAM CEACAM4 IGDCC4 SORL1	1.17e-04	663	80	11	2.60.40.10
Domain	Ig-like_fold	CEACAM19 HSPG2 COL7A1 PTPRS VSTM2L NTRK3 PVR L1CAM CEACAM4 IGDCC4 SORL1	2.03e-04	706	80	11	IPR013783
Domain	Ig-like_dom	CEACAM19 HSPG2 PTPRS VSTM2L NTRK3 PVR L1CAM CEACAM4 IGDCC4	2.95e-04	503	80	9	IPR007110
Domain	IG	HSPG2 PTPRS VSTM2L NTRK3 PVR L1CAM CEACAM4 IGDCC4	4.38e-04	421	80	8	SM00409
Domain	Ig_sub	HSPG2 PTPRS VSTM2L NTRK3 PVR L1CAM CEACAM4 IGDCC4	4.38e-04	421	80	8	IPR003599
Domain	fn3	COL7A1 PTPRS L1CAM IGDCC4 SORL1	6.57e-04	162	80	5	PF00041
Domain	LDLR_class-A_CS	HSPG2 MAMDC4 SORL1	6.67e-04	40	80	3	IPR023415
Domain	Ldl_recept_a	HSPG2 MAMDC4 SORL1	9.43e-04	45	80	3	PF00057
Domain	-	HSPG2 MAMDC4 SORL1	1.01e-03	46	80	3	4.10.400.10
Domain	LDLRA_1	HSPG2 MAMDC4 SORL1	1.14e-03	48	80	3	PS01209
Domain	V-set	CEACAM19 HSPG2 VSTM2L PVR CEACAM4	1.16e-03	184	80	5	PF07686
Domain	IG_LIKE	HSPG2 PTPRS VSTM2L NTRK3 PVR L1CAM CEACAM4 IGDCC4	1.19e-03	491	80	8	PS50835
Domain	FN3	COL7A1 PTPRS L1CAM IGDCC4 SORL1	1.19e-03	185	80	5	SM00060
Domain	LDLRA_2	HSPG2 MAMDC4 SORL1	1.21e-03	49	80	3	PS50068
Domain	LDrepeatLR_classA_rpt	HSPG2 MAMDC4 SORL1	1.21e-03	49	80	3	IPR002172
Domain	LDLa	HSPG2 MAMDC4 SORL1	1.21e-03	49	80	3	SM00192
Domain	Ig_I-set	HSPG2 PTPRS NTRK3 L1CAM IGDCC4	1.34e-03	190	80	5	IPR013098
Domain	ig	HSPG2 PTPRS VSTM2L NTRK3 PVR	1.34e-03	190	80	5	PF00047
Domain	Immunoglobulin	HSPG2 PTPRS VSTM2L NTRK3 PVR	1.34e-03	190	80	5	IPR013151
Domain	I-set	HSPG2 PTPRS NTRK3 L1CAM IGDCC4	1.34e-03	190	80	5	PF07679
Domain	FN3	COL7A1 PTPRS L1CAM IGDCC4 SORL1	1.64e-03	199	80	5	PS50853
Domain	Ig_V-set	CEACAM19 HSPG2 VSTM2L PVR CEACAM4	1.64e-03	199	80	5	IPR013106
Domain	FN3_dom	COL7A1 PTPRS L1CAM IGDCC4 SORL1	2.04e-03	209	80	5	IPR003961
Domain	7tm_3	GPR158 GABBR1	3.96e-03	22	80	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GPR158 GABBR1	3.96e-03	22	80	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GPR158 GABBR1	3.96e-03	22	80	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GPR158 GABBR1	3.96e-03	22	80	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GPR158 GABBR1	3.96e-03	22	80	2	PS50259
Domain	GPCR_3_C	GPR158 GABBR1	3.96e-03	22	80	2	IPR017978
Domain	EGF_LAM_2	HSPG2 STAB1	7.29e-03	30	80	2	PS50027
Domain	EGF_LAM_1	HSPG2 STAB1	7.29e-03	30	80	2	PS01248
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 ABCA2 ZNF276 SETD1B PCNX3 CANT1 PTPRS KCNH2 SUMF1 L1CAM ZNF500 POLRMT C8orf58	3.63e-06	1105	87	13	35748872
Pubmed	BUBR1 Insufficiency Is Correlated with eNOS Reduction Experimentally In Vitro and In Vivo, and in Gastric Cancer Tissue.	BUB1B NOS3	6.19e-06	2	87	2	30396924
Pubmed	Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex.	PTPRS NTRK3	6.19e-06	2	87	2	21262467
Pubmed	Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall.	TERT NOS3	6.19e-06	2	87	2	19948976
Pubmed	Apelin stimulates glucose utilization in normal and obese insulin-resistant mice.	APLN NOS3	6.19e-06	2	87	2	19046574
Pubmed	Development of nano affinity columns for the study of ligand (including SARS-CoV-2 related proteins) binding to heparan sulfate proteoglycans.	HSPG2 TERT	6.19e-06	2	87	2	34132262
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	HSPG2 COL7A1 ABCA2 ABCB7 CANT1 PTPRS PRDX4 SUMF1 PVR L1CAM ENTPD6 MRPS22 SORL1	8.90e-06	1201	87	13	35696571
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	ADORA2A NTRK3 UCN L1CAM NBEA NOS3 GABBR1	1.07e-05	300	87	7	19086053
Pubmed	A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance.	ERBB3 SORL1	1.85e-05	3	87	2	33420373
Pubmed	Estrogen receptor-alpha and endothelial nitric oxide synthase nuclear complex regulates transcription of human telomerase.	TERT NOS3	1.85e-05	3	87	2	18519947
Pubmed	L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling.	ERBB3 L1CAM	3.70e-05	4	87	2	22815787
Pubmed	Impaired D2 dopamine receptor function in mice lacking type 5 adenylyl cyclase.	ADORA2A ADCY5	3.70e-05	4	87	2	12223546
Pubmed	An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.	HSPG2 MEPE	3.70e-05	4	87	2	26428891
Pubmed	Telomerase modulates Wnt signalling by association with target gene chromatin.	TERT AXIN2	3.70e-05	4	87	2	19571879
Pubmed	Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.	ADORA2A NOS3	3.70e-05	4	87	2	21161333
Pubmed	Novel interactors and a role for supervillin in early cytokinesis.	PCNX3 STARD9 HAX1	4.73e-05	28	87	3	20309963
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	COL7A1 PVR DACT2 CEACAM4 OBSCN-AS1 MSTO1 RSKR STAB1	7.45e-05	552	87	8	10737800
Pubmed	Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.	ERBB3 AXIN2	9.22e-05	6	87	2	27782124
Pubmed	Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities.	ERBB3 AXIN2	9.22e-05	6	87	2	34490995
Pubmed	Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family.	CEACAM19 CEACAM4	9.22e-05	6	87	2	16139472
Pubmed	Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS.	ERBB3 NTRK3	9.22e-05	6	87	2	15322547
Pubmed	cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7a1): evidence for rapid evolutionary divergence of the gene.	COL7A1 MST1L	9.22e-05	6	87	2	8325648
Pubmed	A complex oscillating network of signaling genes underlies the mouse segmentation clock.	HSPG2 DACT2 AXIN2	1.10e-04	37	87	3	17095659
Pubmed	Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindles.	ERBB3 NTRK3	1.72e-04	8	87	2	18752272
Pubmed	Genetic mapping of 18S ribosomal RNA-related loci to mouse chromosomes 5, 6, 9, 12, 17, 18, 19, and X.	ZP1 NOS3	2.20e-04	9	87	2	8995758
Pubmed	Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan.	HSPG2 L1CAM	2.20e-04	9	87	2	30149005
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	L1CAM PITPNM3 NBEA RTN1 ADCY5 GABBR1	2.42e-04	347	87	6	17114649
Pubmed	Urocortin expression in the Edinger-Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency.	UCN NOS3	2.75e-04	10	87	2	10614646
Pubmed	A role for neuregulin1 signaling in muscle spindle differentiation.	ERBB3 NTRK3	2.75e-04	10	87	2	12495620
Pubmed	PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.	PTPRS NTRK3	3.35e-04	11	87	2	25624497
Pubmed	Evidence for new homotypic and heterotypic interactions between transmembrane helices of proteins involved in receptor tyrosine kinase and neuropilin signaling.	ERBB3 L1CAM	3.35e-04	11	87	2	25315821
Pubmed	Pdgfrα functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries.	HSPG2 NOS3	3.35e-04	11	87	2	28714851
Pubmed	Liver homeostasis is maintained by midlobular zone 2 hepatocytes.	TERT AXIN2	4.02e-04	12	87	2	33632817
Pubmed	Image-based quantification of histological features as a function of spatial location using the Tissue Positioning System.	TERT AXIN2	4.02e-04	12	87	2	37453365
Pubmed	A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.	ADORA2A NOS3 GABBR1	4.22e-04	58	87	3	11140838
Pubmed	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	ABCB7 PRDX4 POLRMT HAX1 NUDT9 MRPS22 PCK2	4.28e-04	542	87	7	14651853
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	ERBB3 PTPRS NTRK3 L1CAM HOMEZ	4.29e-04	251	87	5	29031500
Pubmed	Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10.	ERBB3 NTRK3	4.74e-04	13	87	2	20626560
Pubmed	Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells.	ERBB3 RTN1	4.74e-04	13	87	2	18036209
Pubmed	Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.	COL7A1 ERBB3 STAB1	5.14e-04	62	87	3	19367581
Pubmed	Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice.	ERBB3 NTRK3	5.52e-04	14	87	2	19936227
Pubmed	Dystroglycan organizes axon guidance cue localization and axonal pathfinding.	HSPG2 L1CAM	5.52e-04	14	87	2	23217742
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	HSPG2 COL7A1 ADAMTS8	5.64e-04	64	87	3	22261194
Pubmed	Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals.	ERBB3 NTRK3	6.36e-04	15	87	2	36765071
Pubmed	Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence.	PTPRS AXIN2	6.36e-04	15	87	2	23863482
Pubmed	Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein Sorting in the Striatal Projection System and Its Deficiency Causes Disturbances in Motor Responses and Monoamine Dynamics.	ADORA2A GABBR1	7.26e-04	16	87	2	35615067
Pubmed	Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells.	NTRK3 L1CAM	7.26e-04	16	87	2	30661738
Pubmed	No replication of genetic association between candidate polymorphisms and Alzheimer's disease.	HSPG2 SORL1	7.26e-04	16	87	2	19889475
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	HSPG2 ABCA2 PVR SORL1	7.83e-04	164	87	4	32409323
Pubmed	Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.	IGF2-AS ERBB3	8.21e-04	17	87	2	17554260
Pubmed	Functional screen identifies regulators of murine hematopoietic stem cell repopulation.	NBEA CRISPLD1	9.22e-04	18	87	2	26880577
Pubmed	Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model.	L1CAM HAX1	9.22e-04	18	87	2	35762573
Pubmed	Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development.	HSPG2 L1CAM	9.22e-04	18	87	2	19587446
Pubmed	Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche.	TERT AXIN2	9.22e-04	18	87	2	26015543
Pubmed	Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification.	VSTM2L NTRK3 RPH3A	9.68e-04	77	87	3	29445148
Pubmed	HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts.	NOS3 AXIN2	1.03e-03	19	87	2	26113728
Pubmed	Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.	HSPG2 ERBB3 CEACAM4	1.12e-03	81	87	3	39217171
Pubmed	Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.	ERBB3 BUB1B	1.14e-03	20	87	2	15504738
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	SETD1B HAX1	1.14e-03	20	87	2	29785026
Pubmed	PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα.	HSPG2 COL7A1	1.26e-03	21	87	2	27856617
Pubmed	Gli3 is required in Emx1+ progenitors for the development of the corpus callosum.	L1CAM AXIN2	1.26e-03	21	87	2	23396189
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	NYNRIN PRDX4 BUB1B HAX1 MRPS22	1.31e-03	322	87	5	39098523
Pubmed	Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation.	L1CAM AXIN2	1.38e-03	22	87	2	25926459
Pubmed	Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.	HSPG2 SORL1	1.38e-03	22	87	2	18448648
Pubmed	Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse.	GPR158 AXIN2	1.38e-03	22	87	2	34905510
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ERBB3 RNF123 ABCA2 WHAMM N4BP2L2 NBEA ADAMTS8 RPH3A MSTO1 STAB1	1.39e-03	1285	87	10	35914814
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	ABCA2 ABCB7 L1CAM CES2	1.43e-03	193	87	4	19343046
Pubmed	The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.	L1CAM NOS3	1.51e-03	23	87	2	17954614
Pubmed	Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.	RPIA PCK2	1.65e-03	24	87	2	25505152
Pubmed	Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors.	ERBB3 AXIN2	1.79e-03	25	87	2	25805134
Pubmed	Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.	IGF2-AS ERBB3	1.79e-03	25	87	2	21829393
Pubmed	Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development.	HSPG2 L1CAM	1.79e-03	25	87	2	28760865
Pubmed	A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development.	L1CAM AXIN2	1.79e-03	25	87	2	32840212
Pubmed	A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome.	ABCB7 PRDX4 POLRMT MRPS22	1.85e-03	207	87	4	20186120
Pubmed	Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death.	NTRK3 NBEA	1.93e-03	26	87	2	26857994
Pubmed	AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.	L1CAM SORL1	1.93e-03	26	87	2	19749747
Pubmed	Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.	WDR38 FRS3 ADAMTS8	2.05e-03	100	87	3	26073538
Pubmed	Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo.	BUB1B AXIN2	2.08e-03	27	87	2	24706806
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	PCNX3 INO80D CRISPLD1 RSKR	2.19e-03	217	87	4	34048709
Pubmed	The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap.	L1CAM AXIN2	2.40e-03	29	87	2	25336744
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	HSPG2 COL7A1	2.40e-03	29	87	2	22613833
Cytoband	13q13.1	ZAR1L N4BP2L2	2.73e-04	13	87	2	13q13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr13q13	ZAR1L N4BP2L2 NBEA	5.22e-04	82	87	3	chr13q13
Cytoband	9q34.3	STPG3 MAMDC4 LCN10	1.10e-03	106	87	3	9q34.3
GeneFamily	Fibronectin type III domain containing	COL7A1 PTPRS L1CAM IGDCC4 SORL1	5.79e-05	160	47	5	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HSPG2 PTPRS NTRK3 L1CAM IGDCC4	5.97e-05	161	47	5	593
GeneFamily	Adenosine receptors\|V-set domain containing	CEACAM19 VSTM2L PVR CEACAM4	8.40e-04	163	47	4	590
GeneFamily	CD molecules\|V-set domain containing\|Immunoglobulin like domain containing\|Carcinoembryonic antigen related cell adhesion molecule family	CEACAM19 CEACAM4	1.76e-03	24	47	2	906
ToppCell	droplet-Liver-Npc-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 NYNRIN NBEA NOS3 GABBR1 STAB1	1.55e-06	182	87	6	dc55de945c6f78f32eb3a1b3520835eb8417e068
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 NYNRIN NBEA NOS3 GABBR1 STAB1	1.55e-06	182	87	6	010a7364da46101cb5068891fd7bc712ea8f13bd
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 NYNRIN NBEA NOS3 GABBR1 STAB1	1.55e-06	182	87	6	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	droplet-Bladder-nan-24m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS8 CRISPLD1 RTN1 NOS3 ADCY5 STAB1	1.71e-06	185	87	6	90caab8d9361a541c5d5121c97c3f1cdffeeae4a
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor\|bone_marrow / Manually curated celltypes from each tissue	PRTN3 APLN BUB1B INAVA CRISPLD1	1.00e-05	146	87	5	035393166f3ad5ab95602a8ae11b7d0ee4b1d691
Drug	Fendiline	KCNH2 NOS3 GABBR1	5.36e-07	5	87	3	ctd:D005275
Drug	Heliotrine [303-33-3]; Up 200; 12.8uM; MCF7; HT_HG-U133A	ADORA2A PRTN3 NYNRIN PVR RPH3A PTGDR2 STAB1	9.94e-06	195	87	7	6035_UP
Drug	Piperacillin sodium salt [59703-84-3]; Up 200; 7.4uM; MCF7; HT_HG-U133A	COL7A1 PRTN3 KCNH2 NYNRIN NTRK3 L1CAM PTGDR2	1.06e-05	197	87	7	3939_UP
Disease	colitis (biomarker_via_orthology)	APLN UCN NOS3	2.20e-04	42	82	3	DOID:0060180 (biomarker_via_orthology)
Disease	spleen volume	TERT ADCY5 RPH3A	2.36e-04	43	82	3	EFO_0600047
Disease	lung adenocarcinoma (is_implicated_in)	ERBB3 TERT AXIN2	3.48e-04	49	82	3	DOID:3910 (is_implicated_in)
Disease	total cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement	SETD1B ADCY5 RPH3A	3.48e-04	49	82	3	EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612
Disease	hypertension (biomarker_via_orthology)	HSPG2 APLN NOS3 ADCY5 GABBR1	4.35e-04	227	82	5	DOID:10763 (biomarker_via_orthology)
Disease	Malignant Neoplasms	ERBB3 KCNH2 TERT NOS3	4.55e-04	128	82	4	C0006826
Disease	Mental Depression	ERBB3 RNF123 UCN NOS3 ADCY5	7.23e-04	254	82	5	C0011570
Disease	pulmonary hypertension (is_marker_for)	APLN TERT NOS3	7.63e-04	64	82	3	DOID:6432 (is_marker_for)
Disease	Unipolar Depression	ADORA2A ERBB3 NTRK3 TERT ADCY5	7.89e-04	259	82	5	C0041696
Disease	Benign Neoplasm	KCNH2 TERT NOS3	9.10e-04	68	82	3	C0086692
Disease	Neoplasms	KCNH2 TERT NOS3	9.10e-04	68	82	3	C0027651
Disease	Paroxysmal atrial fibrillation	HSPG2 KCNH2 NOS3 SORL1	9.54e-04	156	82	4	C0235480
Disease	familial atrial fibrillation	HSPG2 KCNH2 NOS3 SORL1	9.54e-04	156	82	4	C3468561
Disease	Persistent atrial fibrillation	HSPG2 KCNH2 NOS3 SORL1	9.54e-04	156	82	4	C2585653
Disease	Benign neoplasm of stomach	ERBB3 AXIN2	1.01e-03	17	82	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ERBB3 AXIN2	1.01e-03	17	82	2	C0496905
Disease	Carcinoma in situ of stomach	ERBB3 AXIN2	1.01e-03	17	82	2	C0154060
Disease	Atrial Fibrillation	HSPG2 KCNH2 NOS3 SORL1	1.05e-03	160	82	4	C0004238
Disease	Disease Exacerbation	COL7A1 ERBB3 PRDX4 TERT	1.17e-03	165	82	4	C0235874
Disease	Depressive disorder	ADORA2A RNF123 UCN NOS3 ADCY5	1.28e-03	289	82	5	C0011581
Disease	energy expenditure measurement	GPR158 GPATCH2	1.40e-03	20	82	2	EFO_0008005
Disease	Stomach Carcinoma	ERBB3 AXIN2	1.55e-03	21	82	2	C0699791
Disease	Reperfusion Injury	ADORA2A TERT NOS3	1.98e-03	89	82	3	C0035126
Disease	Septicemia	ADORA2A NOS3	2.02e-03	24	82	2	C0036690
Disease	Sepsis	ADORA2A NOS3	2.02e-03	24	82	2	C0243026
Disease	Severe Sepsis	ADORA2A NOS3	2.02e-03	24	82	2	C1719672
Disease	Pyemia	ADORA2A NOS3	2.02e-03	24	82	2	C0034189
Disease	Colorectal cancer	BUB1B AXIN2	2.56e-03	27	82	2	cv:C0346629
Disease	COLORECTAL CANCER	BUB1B AXIN2	2.56e-03	27	82	2	114500
Disease	Neoplasm of the large intestine	BUB1B AXIN2	2.56e-03	27	82	2	cv:C0009404
Disease	oral squamous cell carcinoma (is_implicated_in)	TERT AXIN2	2.75e-03	28	82	2	DOID:0050866 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GPWNTGRSLEHRPRG	BUB1B	311	O60566
RRQANASGHAAWGPP	MAMDC4	831	Q6UXC1
QHRGALGPQLLLNWG	ERBB3	801	P21860
AAPRGGHRPWQGLLI	CEACAM4	6	O75871
LRLNGHPPGVWANGS	ADORA2A	336	P29274
GGSLAQPHRLQRWGP	ADAMTS8	141	Q9UP79
QPHRLQRWGPAGARP	ADAMTS8	146	Q9UP79
HLWGGNSGHPRTTPR	AXIN2	661	Q9Y2T1
HLVQPRGSRNGPGPW	APLN	41	Q9ULZ1
HTPGNRGQGPWELLS	C8orf58	236	Q8NAV2
RQRTNSIGHNPPHWG	ADCY5	661	O95622
LRWLHNGAPLRPNGR	IGDCC4	366	Q8TDY8
LRWFKEGGQLPPGHS	HSPG2	3431	P98160
HRGPLTQLRGHPPRW	NIBAN3	101	Q86XR2
GGSWGRGNPRFHSPQ	HAX1	41	O00165
PQGKGSWGRQPHSNR	MEPE	486	Q9NQ76
RGNPPPTLHWLHNGQ	NTRK3	326	Q16288
LRVAGGHPGNSPWTV	MST1L	486	Q2TV78
RRGPNQGPRGLGHSW	GPR158	236	Q5T848
QIIHPPWEGGIRYRG	GABBR1	31	Q9UBS5
NHRGPPTSWLAPGRA	KCNH2	146	Q12809
PGRPPTHNAHNWRLG	CANT1	66	Q8WVQ1
AGSHPQLRALWGGPI	PCNX3	1791	Q9H6A9
RPGLRLNWHGLSPLG	PCK2	6	Q16822
QALRTNWPAPGGHER	NUPR2	56	A6NF83
LVGRGLLGRWGPNHA	NUDT9	156	Q9BW91
WGLLPGPYHRGEAQR	MSTO1	261	Q9BUK6
RNGNPNGEGLPHWPL	CES2	496	O00748
AVPHKQGGNIRGPWA	RSKR	21	Q96LW2
LRWQPPLSHNGVLTG	L1CAM	936	P32004
GRAQPRHPGTSGHLW	LCN10	91	Q6JVE6
GWGRVGAHDPPAQVL	PRTN3	156	P24158
RAHANPGLRPLVWRG	PTGDR2	271	Q9Y5Y4
ARPGGGRPGWEHSNK	RBBP6	496	Q7Z6E9
QHGWTPGNGRFDVLP	NOS3	276	P29474
WRSPAPGRQHGQIRG	PTPRS	741	Q13332
GRIQHPLWPGSSEGL	RESP18	41	Q5W5W9
PLAGEGHTRWRQPGR	IGF2-AS	151	Q6U949
PAHWPTGRGGLQRRP	DACT2	536	Q5SW24
RQSGHGPPAVRWLLG	DOCK8-AS1	136	Q5T8R8
QHWLGLQTLRGPSRG	FBXO15	11	Q8NCQ5
IGQNLGAHWGRYRPP	CRISPLD1	116	Q9H336
RLSPEEPGWNGLAHR	FRS3	301	O43559
LHKGQEPWSRLGGNP	ABCA2	206	Q9BZC7
WRGQSHRLPAPRGQG	CEACAM19	186	Q7Z692
GGVVNPRTHWGNLPV	INO80D	881	Q53TQ3
PRAQGFLLHWQPEGG	COL7A1	891	Q02388
WPQGLRHNSVPGRVG	HOMEZ	331	Q8IX15
GRQPIGAPAAGNSWH	GPATCH2	6	Q9NW75
EFAQGRPLGPHGLDW	POLRMT	826	O00411
HVVPIRGVPGQWQGR	INAVA	371	Q3KP66
GAWEGAPRQPPRHLQ	NYNRIN	746	Q9P2P1
NGHLQPWIPRPDRRG	OBSCN-AS1	81	Q96MR7
GNSWDLPGSHVRLPG	RPIA	31	P49247
GRPPAQITWHSDLGG	PVR	171	P15151
RARIQPWHGGLLQPL	MRPS22	26	P82650
GPGSQWLRHRGEGEN	RTN1	16	Q16799
RGLRPVAPATGHWNG	SAP25	51	Q8TEE9
WTQRLHGGSAPLPQD	SORL1	31	Q92673
AGWSVHPGGQPDRQR	RPH3A	31	Q9Y2J0
HLAWINTPRRQGGLG	PRDX4	156	Q13162
RAAPGARWGQQAHSP	ENTPD6	76	O75354
VNRWHNTVGLRGAPG	NBEA	2626	Q8NFP9
HQLWRGLSGAARPLP	SKIDA1	136	Q1XH10
GALQPGRLSVHREPW	SMIM43	41	Q4W5P6
LGLQWGRGPSEVNRH	SPATA31E1	1331	Q6ZUB1
PQPGPSGERRNHHWR	SETD1B	16	Q9UPS6
GLRGAHRQLAALWPP	WHAMM	86	Q8TF30
DTQGPNRLWNPHLRG	STARD9	3351	Q9P2P6
RGGLHNRLFPWGNKL	SUMF1	236	Q8NBK3
GSGPQWRPHQLGALG	ABCB7	36	O75027
GEPGRGPLEHGQQWK	C11orf97	36	A0A1B0GVM6
RWLQPDPGLPGLRHS	ZP1	26	P60852
PFWLRHSRAPQGSGP	RNF225	6	M0QZC1
AHLSGGPFAEQPGWR	RIPOR3	456	Q96MK2
EGSHWNEGLLLGRPP	RNF123	721	Q5XPI4
LLGPATEWNHGLPRG	STPG3	321	Q8N7X2
ETAPRLPQHRGWNPG	ZNF276	266	Q8N554
VHPSLWGRPQGLGRG	STAB1	1931	Q9NY15
PPGGGAPWHLRNVLS	PITPNM3	11	Q9BZ71
LPARPPGGWSRNQSH	nan	46	Q8N9P0
PGGWSRNQSHQRRGP	nan	51	Q8N9P0
RSGQLLWRLGGHTGP	WDR38	51	Q5JTN6
LGGATRPAGHAPWDN	VSTM2L	21	Q96N03
PSLRWSPGARNQGGG	UCN	36	P55089
VGQGSWAHPGRTRGP	TERT	251	O14746
LRLHVQWAPTAAGPG	TYSND1	81	Q2T9J0
LGQPGLSGHKQPDWR	ZAR1L	21	A6NP61
SHRPQRGPLLWPERG	ZNF500	186	O60304
PQGRQRWGGSLGSHN	N4BP2L2	561	Q92802