Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

SETD1B KMT2D KMT2A

1.10e-0581183GO:0140945
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

SETD1B KMT2D KMT2A

2.34e-05101183GO:0140999
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

SETD1B KMT2D KMT2A

2.13e-04201183GO:0042800
GeneOntologyMolecularFunctionacid-amino acid ligase activity

TTLL8 TTLL11 TTL

3.27e-04231183GO:0016881
GeneOntologyMolecularFunctionneuroligin family protein binding

NRXN3 NRXN2

3.42e-0451182GO:0097109
GeneOntologyMolecularFunctionthioredoxin-dependent peroxiredoxin activity

PRDX4 PRDX2

7.13e-0471182GO:0140824
GeneOntologyMolecularFunctionthioredoxin peroxidase activity

PRDX4 PRDX2

7.13e-0471182GO:0008379
GeneOntologyCellularComponentmicrotubule

MAP1A MDM1 AKNA TOGARAM1 TTLL8 DNAH14 EHHADH TTLL11 TTL NINL MAP3K11 KIFC1

5.33e-0553311912GO:0005874
GeneOntologyCellularComponentsupramolecular polymer

WHRN SCO2 FLNB COL8A1 COL11A2 MAP1A MDM1 AKNA TOGARAM1 TTLL8 DNAH14 EHHADH TTLL11 TTL NINL MAP3K11 KIFC1 NPNT

1.31e-04118711918GO:0099081
GeneOntologyCellularComponentsupramolecular fiber

WHRN SCO2 FLNB COL11A2 MAP1A MDM1 AKNA TOGARAM1 TTLL8 DNAH14 EHHADH TTLL11 TTL NINL MAP3K11 KIFC1 NPNT

3.68e-04117911917GO:0099512
DomainPost-SET_dom

SETD1B KMT2D KMT2A

1.17e-04161143IPR003616
DomainPostSET

SETD1B KMT2D KMT2A

1.17e-04161143SM00508
DomainPOST_SET

SETD1B KMT2D KMT2A

1.17e-04161143PS50868
DomainFYrich_C

KMT2D KMT2A

3.65e-0451142IPR003889
DomainFYrich_N

KMT2D KMT2A

3.65e-0451142IPR003888
Domain1-cysPrx_C

PRDX4 PRDX2

3.65e-0451142PF10417
DomainFYRC

KMT2D KMT2A

3.65e-0451142SM00542
DomainFYRN

KMT2D KMT2A

3.65e-0451142SM00541
DomainSLED

SFMBT1 SFMBT2

3.65e-0451142IPR021987
DomainSLED

SFMBT1 SFMBT2

3.65e-0451142PF12140
DomainPeroxiredoxin_C

PRDX4 PRDX2

3.65e-0451142IPR019479
DomainFYRN

KMT2D KMT2A

3.65e-0451142PF05964
DomainFYRC

KMT2D KMT2A

3.65e-0451142PF05965
DomainFYRC

KMT2D KMT2A

3.65e-0451142PS51543
DomainFYRN

KMT2D KMT2A

3.65e-0451142PS51542
DomainLRR_8

PODNL1 PIDD1 CHADL TPBGL LRRC47 GP5

6.36e-041711146PF13855
DomainSyndecan

NRXN3 NRXN2

7.60e-0471142PF01034
DomainAhpC/TSA

PRDX4 PRDX2

7.60e-0471142IPR000866
DomainAhpC-TSA

PRDX4 PRDX2

7.60e-0471142PF00578
DomainSyndecan/Neurexin_dom

NRXN3 NRXN2

7.60e-0471142IPR027789
DomainLRR_TYP

PODNL1 PIDD1 CHADL TPBGL LRRC47 GP5

7.62e-041771146SM00369
DomainLeu-rich_rpt_typical-subtyp

PODNL1 PIDD1 CHADL TPBGL LRRC47 GP5

7.62e-041771146IPR003591
DomainMBT

SFMBT1 SFMBT2

1.29e-0391142SM00561
DomainMBT

SFMBT1 SFMBT2

1.29e-0391142PS51079
DomainLeu-rich_rpt

PODNL1 PIDD1 CHADL TPBGL LRRC47 NOD2 GP5

1.38e-032711147IPR001611
DomainLRR

PODNL1 PIDD1 CHADL LRRC47 NOD2 GP5

1.47e-032011146PS51450
DomainANF_lig-bd_rcpt

GRIN2C GRM6 GUCY2D

1.48e-03371143IPR001828
DomainANF_receptor

GRIN2C GRM6 GUCY2D

1.48e-03371143PF01094
DomainMBT

SFMBT1 SFMBT2

1.61e-03101142PF02820
DomainMbt

SFMBT1 SFMBT2

1.61e-03101142IPR004092
DomainPeripla_BP_I

GRIN2C GRM6 GUCY2D

1.72e-03391143IPR028082
DomainLaminin_G_2

COL11A2 NRXN3 NRXN2

1.86e-03401143PF02210
DomainSET

SETD1B KMT2D KMT2A

1.99e-03411143PF00856
DomainThioredoxin_domain

SCO2 PRDX4 PRDX2

1.99e-03411143IPR013766
DomainConA-like_dom

COL11A2 BSPRY NRXN3 NRXN2 LRBA NPNT

2.26e-032191146IPR013320
DomainTHIOREDOXIN_2

SCO2 PRDX4 PRDX2

2.29e-03431143PS51352
DomainLamG

COL11A2 NRXN3 NRXN2

2.44e-03441143SM00282
Domain-

COL11A2 NRXN3 NRXN2 LRBA

2.74e-039511442.60.120.200
DomainTTL

TTLL11 TTL

2.76e-03131142PS51221
DomainTTL/TTLL_fam

TTLL11 TTL

2.76e-03131142IPR004344
DomainTTL

TTLL11 TTL

2.76e-03131142PF03133
DomainSET

SETD1B KMT2D KMT2A

2.78e-03461143SM00317
Domain-

CNNM4 KCNH2 ADI1

3.14e-034811432.60.120.10
DomainNeurexin-like

NRXN3 NRXN2

3.20e-03141142IPR003585
Domain4.1m

NRXN3 NRXN2

3.20e-03141142SM00294
DomainASX_HYDROXYL

HEG1 NRXN3 SCUBE2 NPNT

3.29e-031001144PS00010
DomainSET_dom

SETD1B KMT2D KMT2A

3.52e-03501143IPR001214
DomainSET

SETD1B KMT2D KMT2A

3.52e-03501143PS50280
Domain-

PODNL1 PIDD1 CHADL TPBGL LRRC47 NOD2 GP5

3.56e-0332111473.80.10.10
DomainRmlC-like_jellyroll

CNNM4 KCNH2 ADI1

3.73e-03511143IPR014710
DomainL_dom-like

PODNL1 PIDD1 CHADL TPBGL LRRC47 NOD2 GP5

4.01e-033281147IPR032675
DomainEGF-type_Asp/Asn_hydroxyl_site

HEG1 NRXN3 SCUBE2 NPNT

4.06e-031061144IPR000152
DomainLaminin_G

COL11A2 NRXN3 NRXN2

5.35e-03581143IPR001791
DomainP-loop_NTPase

TRIT1 PEX6 MAGI3 GAL3ST4 DNAH14 SWSAP1 NOD2 MYO15B MDN1 HELZ2 GNAS KIFC1

5.62e-0384811412IPR027417
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SPHK2 ABL1 SETD1B SZT2 MEX3D FBRSL1 AKNA PEX6 MIB2 FAAP100 NOD2 HEG1 KMT2D MDN1 KCNH2 HELZ2 NINL MAP3K11 TNFAIP2 LRBA TIMM22 SMAD7

4.15e-1111051222235748872
Pubmed

Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins.

GRIN2C NRXN3 NRXN2

1.68e-074122335385735
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

SCO2 FLNB COL8A1 PIDD1 MAGI3 PTGER1 DNAH14 LRRC47 MYO15B NOXO1 MDN1 CHRD GP5

2.04e-067361221329676528
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

SETD1B KMT2D KMT2A

2.33e-068122323130995
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

SETD1B KMT2D KMT2A

2.33e-068122322266653
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PGS1 FBRSL1 PEX6 MIB2 MAP3K6 ZXDB AP5B1 DDHD1 KMT2A TNFAIP2 DBR1 KIFC1

3.29e-066501221238777146
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

SETD1B KMT2D KMT2A

3.48e-069122322665483
Pubmed

Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.

KMT2D KMT2A KIFC1

6.81e-0611122318082152
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

SETD1B KMT2D KMT2A

9.05e-0612122327563068
Pubmed

Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts.

SPHK2 SMAD7

1.22e-052122232705254
Pubmed

Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.

KMT2D KMT2A

1.22e-052122226711341
Pubmed

Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.

KMT2D KMT2A

1.22e-052122224423662
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

PGS1 PRRX1 SZT2 KMT2D MYO15B TTLL11 HELZ2 EPS8L3 GNAS DBR1

2.63e-055521221010737800
Pubmed

Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.

NRXN3 NRXN2

3.65e-053122234133920
Pubmed

Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.

NRXN3 NRXN2

3.65e-053122238891114
Pubmed

Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction.

SPHK2 SMAD7

3.65e-053122228807595
Pubmed

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.

NRXN3 NRXN2

3.65e-053122230858964
Pubmed

Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.

KMT2D KMT2A

3.65e-053122226902498
Pubmed

Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.

NRXN3 NRXN2

3.65e-053122228013231
Pubmed

alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.

NRXN3 NRXN2

3.65e-053122216406382
Pubmed

Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.

NRXN3 NRXN2

3.65e-053122231812984
Pubmed

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

KMT2D KMT2A

3.65e-053122223932714
Pubmed

MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo.

KMT2D KMT2A

3.65e-053122223192982
Pubmed

Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.

NRXN3 NRXN2

3.65e-053122212036300
Pubmed

β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.

NRXN3 NRXN2

3.65e-053122226213384
Pubmed

Neurexin gene family variants as risk factors for autism spectrum disorder.

NRXN3 NRXN2

3.65e-053122229045040
Pubmed

Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.

NRXN3 NRXN2

3.65e-053122231005376
Pubmed

Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.

NRXN3 NRXN2

3.65e-053122238571813
Pubmed

Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons.

NRXN3 NRXN2

3.65e-053122235173587
Pubmed

Activation of the Intracellular Pattern Recognition Receptor NOD2 Promotes Acute Myeloid Leukemia (AML) Cell Apoptosis and Provides a Survival Advantage in an Animal Model of AML.

NOD2 KMT2A

3.65e-053122232094205
Pubmed

Neurexins are differentially expressed in the embryonic nervous system of mice.

NRXN3 NRXN2

3.65e-05312227722633
Pubmed

Cdc2/cyclin B1 regulates centrosomal Nlp proteolysis and subcellular localization.

CCNB1 NINL

3.65e-053122220890132
Pubmed

Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.

NRXN3 NRXN2

3.65e-053122226446217
Pubmed

Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

NRXN3 NRXN2

3.65e-053122211944992
Pubmed

Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.

NRXN3 NRXN2

3.65e-053122233058888
Pubmed

Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.

NRXN3 NRXN2

3.65e-053122217035546
Pubmed

Neurexins: three genes and 1001 products.

NRXN3 NRXN2

3.65e-05312229448462
Pubmed

Deletion of α-neurexin II results in autism-related behaviors in mice.

NRXN3 NRXN2

3.65e-053122225423136
Pubmed

Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.

KMT2D KMT2A

3.65e-053122230315824
Pubmed

Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure.

TRPM6 CNNM4

3.65e-053122234140503
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

SETD1B KMT2D KMT2A

6.18e-0522122326886794
Pubmed

Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription.

TFAP2D KMT2D

7.29e-054122218495928
Pubmed

Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.

NRXN3 NRXN2

7.29e-054122214983056
Pubmed

Whirlin complexes with p55 at the stereocilia tip during hair cell development.

WHRN GNAS

7.29e-054122216829577
Pubmed

Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions.

KMT2D KMT2A

7.29e-054122222863532
Pubmed

Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.

NRXN3 NRXN2

7.29e-054122232706374
Pubmed

KDM5A noncanonically binds antagonists MLL1/2 to mediate gene regulation and promotes epithelial to mesenchymal transition.

KMT2D KMT2A

7.29e-054122237722486
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2D KMT2A

7.29e-054122223129768
Pubmed

Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells.

PRDX4 PRDX2

7.29e-054122212080185
Pubmed

TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.

GRM6 GNAS

7.29e-054122219966281
Pubmed

Prognostic impact of KMT2A-AFF1-positivity in 926 BCR-ABL1-negative B-lineage acute lymphoblastic leukemia patients treated in GIMEMA clinical trials since 1996.

ABL1 KMT2A

7.29e-054122234048072
Pubmed

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.

NRXN3 NRXN2

7.29e-05412228786425
Pubmed

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.

KMT2D KMT2A

7.29e-054122224081332
Pubmed

Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.

NRXN3 NRXN2

7.29e-054122217347997
Pubmed

Neurexins cluster Ca2+ channels within the presynaptic active zone.

NRXN3 NRXN2

7.29e-054122232134527
Pubmed

Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2.

ABL1 KMT2D

7.29e-054122227806304
Pubmed

Neurexins regulate presynaptic GABAB-receptors at central synapses.

NRXN3 NRXN2

7.29e-054122233888718
Pubmed

MDM1 is a microtubule-binding protein that negatively regulates centriole duplication.

MDM1 CEP164

1.21e-045122226337392
Pubmed

Evolving Catalytic Properties of the MLL Family SET Domain.

KMT2D KMT2A

1.21e-045122226320581
Pubmed

Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins.

NRXN3 NRXN2

1.21e-045122228472659
Pubmed

Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.

NRXN3 NRXN2

1.21e-045122236709330
Pubmed

Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.

SETD1B KMT2A

1.21e-045122225561738
Pubmed

Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum.

NRXN3 NRXN2

1.21e-045122220537373
Pubmed

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

KMT2D KMT2A

1.21e-045122228609655
Pubmed

Neuroligins and neurexins link synaptic function to cognitive disease.

NRXN3 NRXN2

1.21e-045122218923512
Pubmed

Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration.

NRXN3 NRXN2

1.21e-04512229223334
Pubmed

Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation.

MARS2 TRIT1 TIMM22

1.29e-0428122332376682
Pubmed

Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways.

COL11A2 SMAD7

1.81e-046122218644788
Pubmed

FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair.

FAAP100 FANCE

1.81e-046122218285517
Pubmed

The incidence of T-cell receptor gene rearrangements in childhood B-lineage acute lymphoblastic leukemia is related to immunophenotype and fusion oncogene expression.

ABL1 KMT2A

1.81e-046122216386788
Pubmed

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.

NRXN3 NRXN2

1.81e-046122212827191
Pubmed

Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.

KMT2D KMT2A

1.81e-046122224176642
Pubmed

GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.

KMT2D KMT2A

1.81e-046122234933446
Pubmed

Structures, alternative splicing, and neurexin binding of multiple neuroligins.

NRXN3 NRXN2

1.81e-04612228576240
Pubmed

Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.

NRXN3 NRXN2

1.81e-046122230683685
Pubmed

MLL associates specifically with a subset of transcriptionally active target genes.

KMT2D KMT2A

1.81e-046122216199523
Pubmed

Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing.

SCO2 SLC39A5

1.81e-046122225525168
Pubmed

HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages.

FLNB CCNB1 KIFC1

1.94e-0432122327114546
Pubmed

Mieap forms membrane-less organelles involved in cardiolipin metabolism.

PGS1 CRLS1

2.53e-047122238322995
Pubmed

Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.

KMT2D KMT2A

2.53e-047122236598580
Pubmed

Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.

KMT2D KMT2A

2.53e-047122219219072
Pubmed

Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.

ABL1 FANCE NRXN2 SHARPIN

2.80e-0489122418950845
Pubmed

SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.

ABL1 MAP3K11

3.37e-04812229346925
Pubmed

Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.

NRXN3 NRXN2

3.37e-048122230871858
Pubmed

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.

TRPM6 CNNM4

3.37e-048122233859252
Pubmed

The mutational landscape of lethal castration-resistant prostate cancer.

KMT2D KMT2A

3.37e-048122222722839
Pubmed

Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.

NRXN3 NRXN2

3.37e-048122237591863
Pubmed

FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway.

FAAP100 FANCE

4.32e-049122217396147
Pubmed

Molecular self-avoidance in synaptic neurexin complexes.

NRXN3 NRXN2

4.32e-049122234919427
Pubmed

SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance.

PRDX4 TNFAIP2

4.32e-049122220157331
Pubmed

The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation.

KMT2D KMT2A

4.32e-049122224930734
Pubmed

PRDX6 Inhibits Neurogenesis through Downregulation of WDFY1-Mediated TLR4 Signal.

PRDX4 PRDX2

4.32e-049122230097850
Pubmed

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.

KMT2D KMT2A

4.32e-049122215960974
Pubmed

Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors.

GRM6 GPC5

4.32e-049122230282023
Pubmed

Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.

NOD2 SHARPIN

4.32e-049122223818254
Pubmed

Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

KMT2D KMT2A

4.32e-049122216951254
Pubmed

PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.

NRXN3 NRXN2

4.32e-04912229707552
Pubmed

Identification of novel Smad binding proteins.

PEX6 SMAD7

4.32e-049122214651998
Pubmed

Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.

KMT2D KMT2A

4.32e-049122226691508
Pubmed

Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death.

PRDX4 PRDX2

4.32e-049122215858817
InteractionTOP3B interactions

SCO2 SPHK2 ABL1 SETD1B SZT2 MEX3D FBRSL1 AKNA PEX6 MIB2 FAAP100 NOD2 HEG1 KMT2D MDN1 KCNH2 HELZ2 NINL MAP3K11 TNFAIP2 GNAS LRBA TIMM22 SMAD7

3.20e-06147011724int:TOP3B
Cytoband9q32

WHRN BSPRY AKNA

2.73e-044712239q32
CytobandEnsembl 112 genes in cytogenetic band chr9q32

WHRN BSPRY AKNA

3.28e-04501223chr9q32
GeneFamilyTubulin tyrosine ligase family

TTLL8 TTLL11 TTL

1.72e-0514673779
GeneFamilyPeroxiredoxins

PRDX4 PRDX2

2.01e-046672953
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SETD1B KMT2D KMT2A

2.68e-0434673487
GeneFamilySterile alpha motif domain containing|MBT domain containing

SFMBT1 SFMBT2

4.79e-0496721263
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

MAP3K6 MAP3K11

3.54e-0324672654
GeneFamilyPHD finger proteins

KMT2D PHF3 KMT2A

4.54e-039067388
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL8A1 MAGI3 TACC2 DNAH14 RTKN2 GPC5 LRBA NPNT

6.81e-0819512289406866f99555198a9be311fbd65751b70f35446
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

FLNB COL8A1 MAGI3 TACC2 RTKN2 HEG1 GPC5

4.52e-071701227e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCellCOVID-19-lung-AT1|lung / Disease (COVID-19 only), tissue and cell type

COL8A1 MAGI3 TACC2 DNAH14 RTKN2 GPC5 NPNT

7.41e-071831227942530449e9c6583705eeb8f6f12621daea57252
ToppCellAT1-AT2_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

FLNB COL8A1 MAGI3 RTKN2 HEG1 FAM167A NPNT

7.41e-0718312276821dca076318115d360ff426eb1218cfe104063
ToppCellControl-Epithelial-ATI|World / Disease state, Lineage and Cell class

COL8A1 MAGI3 TACC2 RTKN2 FAM167A GPC5 NPNT

7.98e-0718512270563d5042bb96ecce8446fbf26d05ef7a45e23c5
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RCCD1 ZXDB FANCE SCUBE2 HELZ2 NINL LRBA

8.27e-07186122777bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

RCCD1 ZXDB FANCE SCUBE2 HELZ2 NINL LRBA

8.27e-07186122713bc41c60fd628af31899a5e8b480e06cc4781be
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|368C / Donor, Lineage, Cell class and subclass (all cells)

RCCD1 MAGI3 ZXDB FANCE SCUBE2 NINL LRBA

8.57e-071871227b827d9da7032bf051756ddf88352af922eb0f87b
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|368C / Donor, Lineage, Cell class and subclass (all cells)

RCCD1 MAGI3 ZXDB FANCE SCUBE2 NINL LRBA

8.57e-07187122761c00604dda8b36a5c3eea6554e5601aa1b884f7
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

COL8A1 MAGI3 TACC2 DNAH14 RTKN2 GPC5 NPNT

8.88e-071881227707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL8A1 MAGI3 TACC2 DNAH14 RTKN2 GPC5 NPNT

1.10e-06194122753f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellAT1-AT2_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

PODNL1 HIF3A RTKN2 HEG1 NRXN3 FAM167A

3.00e-061451226cd5de30fd948024e3ad043c9411ce9f2722178b2
ToppCell368C-Fibroblasts-Fibroblast-H-|368C / Donor, Lineage, Cell class and subclass (all cells)

COL8A1 TRIT1 PRRX1 CCNB1 NRXN2 CHRD

3.94e-061521226dbfb4d4de36ef9f5c7da1950baa915b12788685e
ToppCell368C-Fibroblasts-Fibroblast-H|368C / Donor, Lineage, Cell class and subclass (all cells)

COL8A1 TRIT1 PRRX1 CCNB1 NRXN2 CHRD

3.94e-0615212269f3682da00fd627e80aa820ecc6f5fed23b9738a
ToppCellControl|World / group, cell type (main and fine annotations)

MAGI3 TACC2 RTKN2 NRXN3 GPC5 NPNT

7.00e-061681226a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL8A1 PRRX1 COL11A2 CHADL SFMBT2 KIAA1755

7.25e-06169122658e22f9119240664515fe91ca53812611a8f17d6
ToppCellAT1-AT2_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

FLNB COL8A1 MAGI3 RTKN2 FAM167A NPNT

8.84e-061751226bdd85ba280648a0283c1984662a34c7b840f64dd
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PODNL1 COL8A1 COL11A2 CHADL SORCS3 TNFAIP2

8.84e-061751226085cceb1fc2c4ae2f27e85cea5702defecc2cf44
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

COL8A1 MAGI3 TACC2 RTKN2 GPC5 NPNT

1.01e-051791226a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SFMBT1 FLNB PRRX1 HEG1 NINL KIAA1755

1.01e-051791226ce3ca7f3a5864e62307aa744a3173f350a90df28
ToppCellCOPD-Epithelial-ATI|World / Disease state, Lineage and Cell class

COL8A1 TACC2 RTKN2 FAM167A GPC5 NPNT

1.11e-051821226e95d946a43b1579af199900bb0e3eacbb9d65300
ToppCellCOVID-19-lung-AT1|COVID-19 / Disease (COVID-19 only), tissue and cell type

COL8A1 MAGI3 TACC2 RTKN2 GPC5 NPNT

1.14e-0518312267b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCellCOVID-19-Epithelial_cells-ECM-high_epithelial|COVID-19 / group, cell type (main and fine annotations)

FLNB COL8A1 MAGI3 TACC2 HMGCS1 GPC5

1.14e-051831226dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D122|Adult / Lineage, Cell type, age group and donor

COL8A1 MAGI3 TACC2 RTKN2 GPC5 NPNT

1.18e-051841226561592edc3083fad41b91811151b442207c65dd9
ToppCellControl-Epithelial-ATI|Control / Disease state, Lineage and Cell class

COL8A1 TACC2 RTKN2 FAM167A GPC5 NPNT

1.29e-051871226fdd1c57b61ca9392ac27661a82729f37593df63c
ToppCellAT1-AT2_cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

COL8A1 MAGI3 RTKN2 HEG1 FAM167A NPNT

1.33e-051881226be710bc957118cf426dd71c2d57e6f1b41c9a467
ToppCellCOPD-Epithelial-ATI|Epithelial / Disease state, Lineage and Cell class

COL8A1 RTKN2 HEG1 FAM167A GPC5 NPNT

1.37e-05189122614e8e57e4db336fbef005270647983b4edf407c0
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

COL8A1 MAGI3 TACC2 DNAH14 GPC5 NPNT

1.50e-051921226499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

COL8A1 MAGI3 TACC2 DNAH14 GPC5 NPNT

1.50e-051921226efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar-AT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL8A1 MAGI3 RTKN2 FAM167A GPC5 NPNT

1.78e-05198122654228dd9a50616d2022712d162a419ed0327cabd
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL8A1 MAGI3 TACC2 DNAH14 GPC5 NPNT

1.83e-051991226725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL8A1 MAGI3 TACC2 DNAH14 GPC5 NPNT

1.83e-0519912268587bd98de7767a575088afbea07a1feb4516b9b
ToppCellParenchymal-10x5prime-Epithelial-Epi_alveolar-AT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL8A1 MAGI3 TACC2 RTKN2 FAM167A NPNT

1.83e-051991226aca81a879ef9c196bd1885eff4c63ffe6c9682b7
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_alveolar-AT1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

COL8A1 MAGI3 TACC2 RTKN2 FAM167A NPNT

1.89e-0520012263d51aebf626dd4656ab4aac8a20d761b8062c42d
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Mesoderm|5w / Sample Type, Dataset, Time_group, and Cell type.

AKNA NOXO1 HELZ2 CHRD KIAA1755 DBR1

1.89e-0520012260927061536a664b4f7feb9e5b0a8c11ca0d5955c
ToppCellCOVID-19-COVID-19_Mild|COVID-19 / Disease, condition lineage and cell class

AKNA DDHD1 HELZ2 TNFAIP2 GNAS SMAD7

1.89e-05200122662c25042086f1afd1102e0720e933c2e476468fd
ToppCell390C-Myeloid-Macrophage-SPP1+_Macrophage_4|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

TPBGL SFMBT2 HELZ2 TUG1 CCDC17

3.41e-0513412259e12aac8f42790c2f104dfd61c87aa99fc7925f1
ToppCellAT1-AT2_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

COL8A1 MAGI3 PM20D2 RTKN2 NPNT

4.20e-05140122545d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM6 TACC2 LACTBL1 SORCS3 GPC5

4.50e-0514212255b6b0c611c83b23ef7289854a515b78f6cf84500
ToppCellfacs-Thymus-Flowthrough-24m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WHRN MAP3K6 LACTBL1 KMT2A GPC5

7.46e-051581225c870fd17213129943562487338e2669e2930d719
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GPR27 ZAR1 TNFAIP2 GNAS HCRT

7.46e-05158122535f3082109a5930b89d14db3c8fa93148d3a5dd4
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAGI3 TACC2 DNAH14 GPC5 NPNT

7.69e-051591225e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAGI3 TACC2 HIF3A GPC5 NPNT

8.40e-0516212255c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR2 EHHADH GUCY2D SLC39A5 NPNT

9.69e-051671225ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AKNA EHHADH TTL DBR1 KIFC1

1.02e-0416912257cb1b87be66a22fe5731bb1b55bc515920fe3e8b
ToppCelldroplet-Kidney-nan-18m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR2 EHHADH GUCY2D SLC39A5 NPNT

1.02e-041691225f00741203efa0b948db7223ee8c19bdd0918258a
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NECAB2 MAGI3 TACC2 TPBGL SORCS3

1.05e-04170122514aa86a4f526ed6986afcb28c49225522055550c
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NECAB2 MAGI3 TPBGL NRXN3 SORCS3

1.08e-0417112255efd15300f865ebf651e0888265cbd717bc3b9d3
ToppCellwk_20-22-Mesenchymal-Chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

COL8A1 PRRX1 COL11A2 DNAH14 CYP2U1

1.08e-041711225d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCellAT1_cells-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

COL8A1 RTKN2 HEG1 GPC5

1.10e-049012246cbf30dd3992d8ccfaa74ad9781b9f8735f1ef69
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|367C / Donor, Lineage, Cell class and subclass (all cells)

MEX3D MAGI3 NOXO1 MDS2 GPC5

1.11e-041721225a9e65201ad9ab4f64251aba2c0bb3d8f9e0193b6
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|367C / Donor, Lineage, Cell class and subclass (all cells)

MEX3D MAGI3 NOXO1 MDS2 GPC5

1.11e-04172122526006967d0c82f7bd9b36a18e97a1b93e856aa67
ToppCellAT1_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

COL8A1 TACC2 RTKN2 HEG1 FAM167A

1.14e-0417312253afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCellMesenchymal_cells-Osteo-CAR|Mesenchymal_cells / Lineage and Cell class

PODNL1 COL8A1 MIPEP CYP2U1 NPNT

1.17e-041741225430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCellControl-Epithelial_cells-AT1|Control / group, cell type (main and fine annotations)

COL8A1 MAGI3 RTKN2 GPC5 NPNT

1.17e-041741225548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PRRX1 TPBGL ZXDB KCNH2

1.20e-0492122484ac97a16920b912a67ea80e71146eddf9dfa92f
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SFMBT1 FBRSL1 DAO GRIN2C SFMBT2

1.21e-04175122591cb819a1786020713b7e64480de0545380daae9
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Ptprt_Pkp2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NECAB2 MAGI3 TACC2 TPBGL SORCS3

1.24e-04176122505ec715439f2eb1696f5d8855da0dd1dd70effd0
ToppCellLPS-IL1RA+antiTNF|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAGI3 NRXN3 PHF3 LRBA NPNT

1.27e-041771225b7fee75de7e96924af488a5baa2334711889ae7c
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRRX1 MAP1A GAL3ST4 NRXN2 AP5B1

1.34e-041791225b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAGI3 HIF3A NRXN3 GPC5 LRBA

1.34e-041791225815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAGI3 TACC2 RTKN2 NRXN3 NPNT

1.34e-04179122504ce3673e46606f63d9c87bcba3a64c96817d812
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL8A1 PRRX1 ZIC4 CHRD KIAA1755

1.38e-04180122539ae8586efd91536e9ac6408d26de7e6d6237c41
ToppCellfacs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCDHGC4 PEX6 SCUBE2 CYP2U1 NPNT

1.38e-041801225d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCellIPF-Epithelial-ATI|World / Disease state, Lineage and Cell class

COL8A1 TACC2 RTKN2 GPC5 NPNT

1.49e-04183122531fef35ecf30162662f24d335d8f0cceacc07039
ToppCelldroplet-Large_Intestine|droplet / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR2 BSPRY CNNM4 NOXO1 EPS8L3

1.49e-0418312259d7ffcb9804b9a52448ccb56c9370b317a4b52a5
ToppCellwk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

COL8A1 PRRX1 COL11A2 DNAH14 CYP2U1

1.49e-0418312251464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCellIPF-Epithelial-ATI|IPF / Disease state, Lineage and Cell class

COL8A1 TACC2 RTKN2 GPC5 NPNT

1.49e-041831225c0a3541c45bd0c587603521f392f42dd86c3c35b
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

MAGI3 TACC2 HMGCS1 GPC5 NPNT

1.53e-041841225369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL8A1 MAGI3 RTKN2 GPC5 NPNT

1.53e-04184122557c792e6e2fedba25d3350ffe649fd74750b579d
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAGI3 TACC2 RTKN2 GPC5 NPNT

1.53e-04184122529c95b814a0b1ad8734ed68b77df29c08594e5ec
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

COL8A1 MAGI3 RTKN2 GPC5 NPNT

1.53e-041841225d7bd0f0c607bade67c99e9fb3578a570298bf926
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BCL7C CHADL HEG1 FAM167A SMAD7

1.60e-041861225bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAGI3 TACC2 RTKN2 NRXN3 NPNT

1.60e-0418612254e94158db52df41d71e67b02b9895a358eebee0f
ToppCellEpithelial-alveolar_epithelial_cell_type_1|World / Lineage, Cell type, age group and donor

COL8A1 MAGI3 RTKN2 GPC5 NPNT

1.60e-04186122509d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCellCOPD-Epithelial-ATI|COPD / Disease state, Lineage and Cell class

COL8A1 TACC2 RTKN2 GPC5 NPNT

1.60e-041861225df0977f6f48a2d4e11b59971f098b01204242f0f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HIF3A GRIN2C ZIC4 KIAA1755 GPC5

1.64e-0418712254d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAGI3 TACC2 HIF3A GPC5 NPNT

1.64e-0418712255df9e1f5ca32217af255e76e6fb5afa346337811
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FLNB COL8A1 MAGI3 RTKN2 GPC5

1.64e-041871225d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1|Adult / Lineage, Cell type, age group and donor

COL8A1 MAGI3 RTKN2 GPC5 NPNT

1.64e-04187122577f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCellControl-Epithelial-ATI|Epithelial / Disease state, Lineage and Cell class

COL8A1 RTKN2 HEG1 FAM167A GPC5

1.64e-0418712253a032432f780525f4f4c2a358897d9989b1ecae7
ToppCellASK454-Epithelial-Type_1|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

COL8A1 CNNM4 RTKN2 FAM167A NPNT

1.69e-04188122513f8ce8f24ac7d7ed87f4ae3b8f4096de29383c2
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D231|Adult / Lineage, Cell type, age group and donor

COL8A1 MAGI3 RTKN2 GPC5 NPNT

1.73e-0418912255a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HIF3A GRIN2C ZIC4 MYO15B KIAA1755

1.77e-0419012252de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCellfacs-Large_Intestine|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR2 BSPRY CNNM4 NOXO1 EPS8L3

1.77e-041901225cf752ab09db7432a24ecdc60336ade738a9b703b
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL8A1 MAGI3 RTKN2 HEG1 GPC5

1.77e-04190122530b50d183d7649146eb1e79b47ba897355f1998a
ToppCellLAM-Epithelial-AT1|LAM / Condition, Lineage and Cell class

COL8A1 MAGI3 RTKN2 FAM167A NPNT

1.81e-04191122566875b2ec2c510489407f3e433a90cdf74a15094
ToppCellfacs-Heart-LV-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL8A1 PRRX1 CHRD KIAA1755 TNFAIP2

1.81e-041911225b7a57691a4742070cee640e285c1f4d0da95baf1
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

MAGI3 TACC2 DNAH14 GPC5 NPNT

1.81e-041911225276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

MAGI3 TACC2 DNAH14 GPC5 NPNT

1.81e-041911225e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HIF3A GRIN2C ZIC4 MYO15B KIAA1755

1.81e-041911225f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCellASK454-Epithelial-Secretory|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

MEX3D BCL7C SFMBT2 PM20D2 NPNT

1.81e-041911225c63c781e7e93265e591cf494cb4ce8ed797c24fb
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAGI3 TACC2 HIF3A GPC5 NPNT

1.86e-04192122529f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

TACC2 HMGCS1 DNAH14 NRXN3 NPNT

1.86e-04192122506013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellAT1_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

COL8A1 RTKN2 HEG1 FAM167A NPNT

1.86e-0419212250444f9e9cef7403e220e862b5a787443d3f5c9ac
ToppCell(3)_Chondrocytes-(33)_Chondro-prol/rest|World / Cell class and subclass of bone marrow stroma cells in homeostatis

COL11A2 HMGCS1 CHADL CCNB1 KIFC1

1.95e-041941225c093c5e161b97ad770bfbaad3023eba4537101b5
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL8A1 PRRX1 MAP1A TACC2 NPNT

1.95e-041941225aaecde88bd54134a938e76cdf059c1c2653e4e77
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PRRX1 ABL1 HIF3A CHRD KIAA1755

2.00e-041951225ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCellAT2_cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

TACC2 HMGCS1 PRDX2 ADI1 NPNT

2.00e-0419512250792c1e959e933b10ae987d821ff43020dfdabad
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL8A1 MAGI3 RTKN2 GPC5 NPNT

2.00e-041951225a71ba5e4043e2d35a45a2c60a96b087e31832345
DrugCyclobenzaprine hydrochloride [6202-23-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A

WHRN PODNL1 SPHK2 SZT2 CDHR2 DELE1 KCNH2 KMT2A TNFAIP2

1.02e-0619512193268_UP
DrugAmyleine hydrochloride [532-59-2]; Down 200; 14.8uM; HL60; HG-U133A

SETD1B MAP1A SZT2 BCL7C PIDD1 SCAF4 MIPEP ADI1

1.06e-0519712181991_DN
DrugMidecamycin [35457-80-8]; Down 200; 5uM; PC3; HG-U133A

BCL7C TACC2 DELE1 PRDX2 GRM6 MAP3K6 FAAP100 TM9SF2

1.10e-0519812181943_DN
DrugPromazine hydrochloride [53-60-1]; Up 200; 12.4uM; MCF7; HT_HG-U133A

SPHK2 SETD1B SZT2 HEG1 PHF3 TNFAIP2 EPS8L3 GP5

1.19e-0520012183833_UP
DiseaseSPASTIC PARAPLEGIA 56, AUTOSOMAL RECESSIVE

DDHD1 CYP2U1

1.67e-0521212C3539507
Diseasetriglyceride measurement, coronary artery disease

SETD1B FBRSL1

9.95e-0541212EFO_0001645, EFO_0004530
Diseasebactericidal permeability-increasing protein measurement

EHHADH KIAA1755

1.65e-0451212EFO_0020172
DiseaseTinnitus

FBRSL1 RTKN2 CHRD SORCS3 GPC5

2.03e-041301215HP_0000360
Diseaseurate measurement, bone density

TRPM6 FBRSL1 MAGI3 GRIN2C SFMBT2 DNAH14 MIPEP HELZ2 KIAA1755 GPC5

2.41e-0461912110EFO_0003923, EFO_0004531
DiseaseCombined oxidative phosphorylation deficiency

MARS2 TRIT1 MIPEP

4.72e-04371213cv:C4540031
Diseasemitochondrial ubiquitin ligase activator of NFKB 1 measurement

EHHADH KIAA1755

5.89e-0491212EFO_0801804
Diseaseaortic stenosis, aortic valve calcification

FLNB PRRX1 FBRSL1

6.87e-04421213EFO_0000266, EFO_0005239
DiseaseMicrophthalmos

PRSS56 KMT2D

8.95e-04111212C0026010
Diseasecoagulation factor XA measurement

WHRN AKNA

8.95e-04111212EFO_0020266
DiseaseBipolar I disorder

DAO NRXN3

8.95e-04111212C0853193
Diseasepneumonia

TM9SF2 HELZ2 ADI1

9.56e-04471213EFO_0003106
Diseasecleft palate (is_implicated_in)

FLNB COL11A2

1.07e-03121212DOID:674 (is_implicated_in)
DiseaseSpastic Paraplegia, Hereditary

DDHD1 CYP2U1

1.47e-03141212C0037773
DiseaseMyopia

SCO2 PRSS56

1.69e-03151212C0027092
DiseaseDisorder of eye

WHRN COL11A2 GRM6 CNNM4 GUCY2D

1.85e-032121215C0015397
Diseasemyopia (is_implicated_in)

SCO2 SLC39A5

1.93e-03161212DOID:11830 (is_implicated_in)
DiseaseDermatitis

NOD2 SHARPIN

1.93e-03161212C0011603
DiseaseMyeloid Leukemia

PRDX2 KMT2A

2.44e-03181212C0023470
DiseaseLeukemia, Monocytic, Chronic

PRDX2 KMT2A

2.44e-03181212C0023466
Diseaseosteochondrodysplasia (is_implicated_in)

FLNB COL11A2

2.72e-03191212DOID:2256 (is_implicated_in)
Diseasefacial asymmetry measurement

NRXN3 SMAD7

2.72e-03191212EFO_0009751
Diseasenon-high density lipoprotein cholesterol measurement

PGS1 FBRSL1 AKNA PEX6 MAP3K6 SCAF4 ZIC4 FIZ1 SMAD7

2.73e-037131219EFO_0005689
Diseaseopioid dependence

DAO TACC2 SFMBT2 ZIC4 NRXN3

2.99e-032371215EFO_0005611
DiseasePrecursor B-cell lymphoblastic leukemia

ABL1 KMT2A

3.33e-03211212C1292769
Diseaserenal system measurement, blood urea nitrogen measurement

TFAP2D GNAS

3.65e-03221212EFO_0004741, EFO_0004742
DiseaseParoxysmal atrial fibrillation

PRRX1 FBRSL1 KCNH2 SMAD7

3.96e-031561214C0235480
Diseasefamilial atrial fibrillation

PRRX1 FBRSL1 KCNH2 SMAD7

3.96e-031561214C3468561
DiseasePersistent atrial fibrillation

PRRX1 FBRSL1 KCNH2 SMAD7

3.96e-031561214C2585653

Protein segments in the cluster

PeptideGeneStartEntry
PIRLLRGLLARLPGG

GNAS

476

P84996
PAPLQLGLGRERLGA

FBRSL1

876

Q9HCM7
QRGRAPLGPQDLRLL

CCDC17

316

Q96LX7
VAGGLLRGPPLLLRA

DMRTA2

46

Q96SC8
RLLPGPSLGLAAAGA

TFAP2D

161

Q7Z6R9
IGPNAPLIFERGLRG

HMGCS1

181

Q01581
GLLAVLRAGPGPEAL

RCCD1

81

A6NED2
RGNPELARLRPGLAV

HAGHL

61

Q6PII5
AGALQRDPLLQPGRG

DAO

186

P14920
PHSGRLGPAAIGLLL

DSG3

611

P32926
AEPPRRGSLLELGQG

OTOP3

491

Q7RTS5
GLLARLPRPQDQGCG

FAM201A

121

Q5SY85
PVGSGLRGLQRTLPL

TRIT1

11

Q9H3H1
NLRPGLCLGRIDPKG

MDN1

1561

Q9NU22
PILGAEALPGGLRTL

MAP1A

1111

P78559
LLLLRPGTGLIPDHG

MAGI3

1096

Q5TCQ9
PGGKAARLVLPLGRL

NPNT

461

Q6UXI9
AARLNRDPGLAGGPR

GUCY2D

81

Q02846
LLGAVRGLPDSPRAG

GPC5

41

P78333
LPGGRDRAGRPLLLV

KIAA1755

581

Q5JYT7
VLRRNALGPGLSPEL

LRRC47

81

Q8N1G4
GPTRRLSLPGQLGAL

KCNH2

1131

Q12809
RLDPGLALGPGERER

KIFC1

571

Q9BW19
TLGLLPGARGTQLLP

EHHADH

126

Q08426
LRAQGLGPALLHRPL

MAP3K6

1066

O95382
RPDGAPGALGFLLLL

GPR27

176

Q9NS67
GLAPLEVRVLGPRGL

FLNB

1451

O75369
RLLGLLPGRPGLAAL

PGS1

16

Q32NB8
LPGRPGLAALLGRLS

PGS1

21

Q32NB8
QLLRLLPPRAGAKGG

PTGER1

361

P34995
TRPALQGLLGPGTRL

PEX6

141

Q13608
LEQRPRLGGLQPGQD

EPS8L3

151

Q8TE67
GRLPTPKLRELGGIQ

MDM1

511

Q8TC05
RGLLANLKLGERPPA

NRXN2

176

Q9P2S2
ERPPALLGSQGLRGA

NRXN2

186

Q9P2S2
YLGGLPENRAGLILP

NRXN3

581

Q9Y4C0
AILQQARLALRGPPG

COL11A2

476

P13942
GGLRLELPLSRRGAP

MEX3D

521

Q86XN8
GALSLKPGLPIRGIR

LRBA

31

P50851
PLGPQGLEGLVSRHL

AP5B1

801

Q2VPB7
PLAGAGLELQLERRP

HEG1

46

Q9ULI3
EGLPPSNGILRIQLG

PCDHGC4

741

Q9Y5F7
QLGPGARREVTLPLG

FAAP100

571

Q0VG06
ALQLLGGPFQRRLPG

GAL3ST4

31

Q96RP7
GGARGRPQLTLERPL

MDS2

61

Q8NDY4
RKEGGLGPLNIPLLA

PRDX2

91

P32119
GLRLLKVTQGPGLRP

MYO15B

1351

Q96JP2
SGLPAGALRPLRGLH

PODNL1

326

Q6PEZ8
LRAPLGLLRLDPSGG

CYP2U1

21

Q7Z449
KPGLRPRTALGDIGN

CCNB1

36

P14635
DPDTGLLRNLGPLDR

CDHR2

636

Q9BYE9
ADPELLPGVRLGARL

GRM6

81

O15303
QHEPLGLLRGPAQLG

BSPRY

341

Q5W0U4
PRGGGPLILLDLNDE

BCL7C

81

Q8WUZ0
ALLGGGPRRLLRPDA

LACTBL1

266

A8MY62
GAPELGSLRPGDRAL

FAM83C

566

Q9BQN1
LLPRKERGPPEGGLN

ABL1

571

P00519
RQGRPLPRQGATLAG

AKNA

326

Q7Z591
IPLASLRGEQGPRGE

COL8A1

111

P27658
PSLALAGVGGPDLRR

DNAH14

146

Q0VDD8
PLASDRRLLLGPAGG

FIZ1

286

Q96SL8
LRQHLGLVGGEEPPR

GP5

436

P40197
GLGGAPRQRVPALLL

KMT2A

26

Q03164
ALAERRGPGPVDLLL

DBR1

21

Q9UK59
LALLRGEPGLHLAPG

DDHD1

56

Q8NEL9
LGLGGRRLKSPQAPD

FANCE

171

Q9HB96
LPGPVLSQARGLARL

CHADL

221

Q6NUI6
LGQGRRPGPCRNLAL

HELZ2

271

Q9BYK8
STGLLGARPGLIPLQ

SCAF4

846

O95104
LLLAGAVPPGRGRAA

SCUBE2

26

Q9NQ36
QPQGPGLRTRLLITG

SCO2

51

O43819
LRPAALGLRLPGIGQ

CRLS1

51

Q9UJA2
LRGLQAGARRAPDPG

DPP7

16

Q9UHL4
LLASLGLGRDLQPPG

MAP3K11

651

Q16584
GLLGRALPRTLGPSL

DELE1

6

Q14154
PRRGAGLSLAPLNLG

PIDD1

766

Q9HB75
GLLRNAQELLGPRPG

PRSS56

406

P0CW18
AQELLGPRPGLRRLA

PRSS56

411

P0CW18
RQGLPRIPLRGIFQG

MIB2

146

Q96AX9
SGPPGLQGRLQRLLQ

HCRT

71

O43612
RGGQEPLLPLREAGQ

FAM167A

76

Q96KS9
LRGPALRLAGLPTQQ

RTKN2

6

Q8IZC4
VGALRRGGIPQSPAL

SZT2

1706

Q5T011
QGGLGPIRIPLLSDL

PRDX4

166

Q13162
GRPGAPLVRTGLLLL

SORCS3

11

Q9UPU3
SPDLRRLLGPILDGA

HIF3A

411

Q9Y2N7
PRAAAGLLPGGKARE

STRIP1

36

Q5VSL9
ERPGRFRLELLGAGP

SHARPIN

51

Q9H0F6
LVRPPAGAALGRELL

SETD1B

1536

Q9UPS6
GEGQGPVLFLTRRPL

SWSAP1

31

Q6NVH7
GNDLPLGQPRKLGRE

WHRN

591

Q9P202
DGRRRQLPGLGPAGI

NINL

591

Q9Y2I6
AGLEQPGARELPLLG

NINL

931

Q9Y2I6
DRAGLLPAVLLRPEG

NOXO1

281

Q8NFA2
AALGVRGALEGLPRP

PM20D2

136

Q8IYS1
LLGPRLLRPLLGFLG

SLC39A5

236

Q6ZMH5
HVPLGGLAPLRGLVD

CEP164

141

Q9UPV0
LLLLGSRPARGAGPE

CHRD

16

Q9H2X0
VGGPARGRLLLAAPV

CNNM4

11

Q6P4Q7
TRRLLLLRGPQDGGP

ZXDB

41

P98169
LGLGRRLSLPGPRLD

TTLL11

21

Q8NHH1
LLLPGRLDCRLGPGA

SMAD7

126

O15105
GLPLALLAPLRGAAE

TTLL8

661

A6PVC2
GMGLGSLLPPRQIRL

TNFAIP2

301

Q03169
LAGGRHPPRVQRGAL

TRPM6

1286

Q9BX84
RLGGLGARAAALPPR

MIPEP

6

Q99797
ASQGLGPSLLRGRLP

NOD2

531

Q9HC29
PRLLLLVNPFGGRGL

SPHK2

181

Q9NRA0
NLLEGPLRGKGPIDL

SFMBT2

171

Q5VUG0
PLPGLVGRRNGRAVD

TUG1

6

A0A6I8PU40
GPGLELHRPNLLLGL

PHF3

1331

Q92576
QDALLPARELGGIPR

TACC2

1191

O95359
GRRLGPETGLLFPRL

MARS2

566

Q96GW9
SRPLNGLLRLGLPGD

ZIC4

56

Q8N9L1
LLLLGAVPGPRRSGA

TM9SF2

21

Q99805
KRQPRLLEPGSLGGI

TIMM22

36

Q9Y584
RALERDGGLPGPRLL

TPBGL

216

P0DKB5
VPLLEGLRNGRNPLD

SFMBT1

146

Q9UHJ3
GLRNGRNPLDLIAPG

SFMBT1

151

Q9UHJ3
LQAALPRRGGRLGFP

TOGARAM1

116

Q9Y4F4
RQPALGGRLDSPGNL

PRRX1

11

P54821
RLPFGRLGHEPGLVQ

TTL

46

Q8NG68
LLAQVGPGLGPRARR

ZAR1

86

Q86SH2
LAPEGLRGLAVSGLP

KMT2D

2916

O14686
DPGRPVGLEQLRRLG

ADI1

21

Q9BV57
LELGPGGPRARTQRL

GRIN2C

201

Q14957
LLREPPQQGRALGGL

NECAB2

16

Q7Z6G3